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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trioxsalen
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Accession:CHEBI:28329 term browser browse the term
Definition:7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Synonyms:exact_synonym: 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
 related_synonym: 2',4,8-Trimethylpsoralen;   4,8,5'-Trimethylpsoralen;   6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone;   Formula=C14H12O3;   InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3;   InChIKey=FMHHVULEAZTJMA-UHFFFAOYSA-N;   SMILES=Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1;   Trimethylpsoralen;   trioxisaleno;   trioxysalen;   trioxysalene;   trioxysalenum
 alt_id: CHEBI:1758;   CHEBI:20282
 xref: Beilstein:221723;   CAS:3902-71-4;   DrugBank:DB04571;   Drug_Central:2759;   KEGG:C09314;   KEGG:D01034;   KNApSAcK:C00002502;   LINCS:LSM-3223
 xref_mesh: MESH:D014307
 xref: Patent:US3201421;   Wikipedia:Trioxsalen


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trioxsalen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO Trioxsalen analog inhibits the reaction [IFNG protein results in increased expression of NOS2 protein] CTD PMID:16259964 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases activity		 ISO Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased activity of JUN protein] CTD PMID:16259964 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased expression of NOS2 mRNA]; Trioxsalen analog inhibits the reaction [IFNG protein results in increased expression of NOS2 protein] CTD PMID:16259964 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pharmaceutical 19548
          drug 19548
            photosensitizing agent 7892
              trioxsalen 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18320
                                    organic heterotricyclic compound 15876
                                      furochromene 136
                                        furanocoumarin 136
                                          psoralens 128
                                            trioxsalen 3
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