CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | fluorene |
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Accession: | CHEBI:28266
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browse the term
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Definition: | An ortho-fused tricyclic hydrocarbon that is a major component of fossil fuels and their derivatives |
Synonyms: | related_synonym: | 2,2'-Methylenebiphenyl; 2,3-benzindene; 9H-fluorene; Diphenylenemethane; Fluoren; Formula=C13H10; InChI=1S/C13H10/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)12/h1-8H,9H2; InChIKey=NIHNNTQXNPWCJQ-UHFFFAOYSA-N; SMILES=C1C2=CC=CC=C2C2=CC=CC=C12; o-biphenylenemethane; o-biphenylmethane |
| alt_id: | CHEBI:24058; CHEBI:5112 |
| xref: | CAS:86-73-7; Chemspider:6592; FooDB:FDB007671; Gmelin:28451; KEGG:C07715 |
| xref_mesh: | MESH:C041509 |
| xref: | MetaCyc:FLUORENE; PDBeChem:9FL; PMID:15120562; PMID:15800860; PMID:16539455; PMID:17129129; PMID:17243671; PMID:17285163; PMID:17824593; PMID:19060398; PMID:21110374; PMID:21478643; PMID:23202077; PMID:24584240; PMID:24889657; PMID:28409789; Reaxys:1363491; UM-BBD_compID:c0388; Wikipedia:Fluorene |
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Ahr |
aryl hydrocarbon receptor |
multiple interactions increases activity |
ISO |
[acenaphthene co-treated with anthracene co-treated with 1,12-benzoperylene co-treated with 1,2,5,6-dibenzanthracene co-treated with fluorene co-treated with naphthalene co-treated with phenanthrene] results in increased activity of AHR protein fluorene results in increased activity of AHR protein |
CTD |
PMID:17665671 |
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NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Ahrr |
aryl-hydrocarbon receptor repressor |
decreases methylation |
ISO |
fluorene metabolite results in decreased methylation of AHRR gene |
CTD |
PMID:32385190 |
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NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:28,993,634...29,088,673
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Cat |
catalase |
increases activity multiple interactions |
ISO |
fluorene results in increased activity of CAT protein [phenanthrene co-treated with fluorene] results in increased activity of CAT protein |
CTD |
PMID:32856796 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
fluorene results in increased expression of CYP1A1 protein |
CTD |
PMID:10445401 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity multiple interactions |
ISO |
fluorene results in increased activity of CYP1A2 protein [acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA |
CTD |
PMID:7750161 PMID:8001243 |
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
fluorene results in increased expression of CYP2B1 protein |
CTD |
PMID:10445401 |
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NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
fluorene results in increased expression of CYP3A2 protein |
CTD |
PMID:10445401 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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F2rl3 |
F2R like thrombin or trypsin receptor 3 |
decreases methylation |
ISO |
fluorene metabolite results in decreased methylation of F2RL3 gene |
CTD |
PMID:32385190 |
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NCBI chr16:17,151,516...17,153,509
Ensembl chr16:17,117,441...17,119,472
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Gja1 |
gap junction protein, alpha 1 |
decreases expression decreases localization |
ISO |
fluorene results in decreased expression of GJA1 protein fluorene results in decreased localization of GJA1 protein |
CTD |
PMID:30668803 |
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NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
fluorene results in increased expression of IL6 mRNA; fluorene results in increased expression of IL6 protein [fluorene co-treated with phenanthrene] results in increased expression of IL6 mRNA; [fluorene co-treated with phenanthrene] results in increased expression of IL6 protein |
CTD |
PMID:32856796 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Nos3 |
nitric oxide synthase 3 |
multiple interactions increases expression |
ISO |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [fluorene results in increased expression of NOS3 mRNA]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [fluorene results in increased expression of NOS3 protein]; nickel chloride inhibits the reaction [fluorene results in increased expression of NOS3 protein]; Proadifen inhibits the reaction [fluorene results in increased expression of NOS3 protein] fluorene results in increased expression of NOS3 mRNA; fluorene results in increased expression of NOS3 protein |
CTD |
PMID:15183461 |
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NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
fluorene results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
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Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
fluorene results in decreased expression of TGFB1 mRNA |
CTD |
PMID:32856796 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
[fluorene co-treated with phenanthrene] results in increased expression of TNF mRNA; [fluorene co-treated with phenanthrene] results in increased expression of TNF protein fluorene results in increased expression of TNF mRNA; fluorene results in increased expression of TNF protein |
CTD |
PMID:32856796 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Ahr |
aryl hydrocarbon receptor |
affects binding |
EXP |
1-methylfluorene binds to AHR protein |
CTD |
PMID:3024361 |
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NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Aaas |
aladin WD repeat nucleoporin |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AAAS mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
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Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression increases expression multiple interactions increases activity |
ISO EXP |
2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNA lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA] 2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 protein Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein] 2-Acetylaminofluorene results in increased activity of ABCB1 protein [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] |
CTD |
PMID:11170838 PMID:11960367 PMID:12387747 PMID:17303067 PMID:17669244 PMID:21784091 PMID:22213190 More...
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NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of ABCB1B mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1B protein [2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased expression of ABCB1B mRNA; lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA] |
CTD |
PMID:11020383 PMID:11170838 PMID:12801967 PMID:17070881 PMID:22084566 |
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NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
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Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ABCC1 mRNA |
CTD |
PMID:12801967 PMID:17669244 |
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NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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Abcc10 |
ATP binding cassette subfamily C member 10 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ABCC10 mRNA |
CTD |
PMID:12566991 |
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NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
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Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of ABCC2 mRNA 2-Acetylaminofluorene results in increased expression of ABCC2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA] |
CTD |
PMID:10691972 PMID:16381673 PMID:16426233 |
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NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of ABCC3 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC3 protein |
CTD |
PMID:10691972 PMID:12801967 |
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NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
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Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression increases activity multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA 2-Acetylaminofluorene results in increased activity of ABCG2 protein 2-Acetylaminofluorene results in increased expression of ABCG2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCG2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA] |
CTD |
PMID:12819005 PMID:16381673 PMID:17538966 PMID:17669244 PMID:27475308 |
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NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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Acaa2 |
acetyl-CoA acyltransferase 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA |
CTD |
PMID:14656948 |
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NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249
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Acmsd |
aminocarboxymuconate semialdehyde decarboxylase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ACMSD mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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Acot9 |
acyl-CoA thioesterase 9 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ACOT9 mRNA |
CTD |
PMID:21784091 |
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NCBI chr X:43,922,943...43,973,311
Ensembl chr X:40,064,810...40,123,559
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Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ACSL3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627
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Aen |
apoptosis enhancing nuclease |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of AEN mRNA |
CTD |
PMID:17070881 PMID:21607683 PMID:22584684 |
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NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:132,815,142...132,824,523
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Afp |
alpha-fetoprotein |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein 2-Acetylaminofluorene results in increased expression of AFP mRNA; 2-Acetylaminofluorene results in increased expression of AFP protein |
CTD |
PMID:6187438 PMID:11350689 PMID:11813887 PMID:15133858 PMID:17538966 |
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NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
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Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AHR mRNA |
CTD |
PMID:25224404 |
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NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Ak1 |
adenylate kinase 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AK1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041
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Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of AKR1B1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10 |
aldo-keto reductase family 1 member B10 |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA 2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA |
CTD |
PMID:14656948 PMID:26198647 |
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NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852
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Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of AKR7A3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA 2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:11960367 PMID:17303067 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Alb |
albumin |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of ALB protein 2-Acetylaminofluorene results in increased expression of ALB protein |
CTD |
PMID:6187438 PMID:15133858 |
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NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA; 2-Acetylaminofluorene results in increased expression of ALDH1A1 protein |
CTD |
PMID:17070881 PMID:22584684 PMID:33211169 |
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NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
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Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ALDH1A3 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:119,982,277...120,017,436
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Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681
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Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein] |
CTD |
PMID:15548946 PMID:15554553 |
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NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
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Anapc11 |
anaphase promoting complex subunit 11 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ANAPC11 mRNA |
CTD |
PMID:22584684 |
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NCBI chr10:106,373,610...106,384,633
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Anxa3 |
annexin A3 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of ANXA3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA] [Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA |
CTD |
PMID:17317680 PMID:18071240 |
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NCBI chr14:13,031,675...13,085,678
Ensembl chr14:12,719,795...12,781,617
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Anxa8 |
annexin A8 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ANXA8 mRNA |
CTD |
PMID:17317680 |
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NCBI chr16:9,403,267...9,418,317
Ensembl chr16:9,397,113...9,412,043
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Aox1 |
aldehyde oxidase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Apoa2 |
apolipoprotein A2 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of APOA2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:86,176,767...86,178,819
Ensembl chr13:83,644,470...83,646,355
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Apoa4 |
apolipoprotein A4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of APOA4 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469
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Apoc3 |
apolipoprotein C3 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of APOC3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583
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Apod |
apolipoprotein D |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of APOD mRNA |
CTD |
PMID:20713471 |
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NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305
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Aqp5 |
aquaporin 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of AQP5 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:130,721,748...130,726,209
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Areg |
amphiregulin |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of AREG mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA] |
CTD |
PMID:17317680 |
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NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535
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Asgr1 |
asialoglycoprotein receptor 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ASGR1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr10:55,274,299...55,278,323
Ensembl chr10:54,776,024...54,779,631
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Atp6v1d |
ATPase H+ transporting V1 subunit D |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ATP6V1D mRNA |
CTD |
PMID:17070881 |
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NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:97,656,576...97,672,303
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Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO EXP |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA] 2-Acetylaminofluorene results in increased expression of BAX mRNA [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein] |
CTD |
PMID:11915028 PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 More...
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein] 2-Acetylaminofluorene results in increased expression of BCL2 mRNA |
CTD |
PMID:11915028 PMID:19167416 PMID:22213190 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein] 2-Acetylaminofluorene results in increased expression of BCL2L1 mRNA |
CTD |
PMID:11915028 PMID:21607683 |
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NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of BIRC5 mRNA |
CTD |
PMID:19167416 PMID:22213190 |
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NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of BRCA1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
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G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of BTG2 mRNA |
CTD |
PMID:17070881 PMID:21607683 |
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NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
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Bzw1 |
basic leucine zipper and W2 domains 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of BZW1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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G |
C4bpa |
complement component 4 binding protein, alpha |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of C4BPA mRNA |
CTD |
PMID:16510358 |
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NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205
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C6 |
complement C6 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of C6 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275
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C7 |
complement C7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of C7 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535
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Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:18,951,002...19,374,969
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G |
Cadm1 |
cell adhesion molecule 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CADM1 protein |
CTD |
PMID:17326163 |
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NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:47,847,325...48,182,833
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G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CAR2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAR2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity |
EXP |
2-Acetylaminofluorene inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased cleavage of CASP3 protein]; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein] |
CTD |
PMID:12907702 PMID:23665045 PMID:26364502 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] |
CTD |
PMID:23665045 |
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NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
increases activity increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased activity of CASP9 protein 2-Acetylaminofluorene results in increased expression of CASP9 protein Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein] |
CTD |
PMID:23665045 PMID:26364502 |
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Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity decreases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of CAT protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein] |
CTD |
PMID:17761372 PMID:23665045 PMID:26364502 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Cavin3 |
caveolae associated protein 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAVIN3 mRNA |
CTD |
PMID:14656948 |
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NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
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G |
Cblc |
Cbl proto-oncogene C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CBLC mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:79,439,977...79,456,755
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G |
Cbr1 |
carbonyl reductase 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CBR1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cck |
cholecystokinin |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CCK mRNA |
CTD |
PMID:22584684 |
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NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CCL2 mRNA; 2-Acetylaminofluorene affects the expression of CCL2 protein |
CTD |
PMID:25051504 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CCL7 protein |
CTD |
PMID:25051504 |
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NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,016,446...67,018,303
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of CCN2 mRNA; 2-Acetylaminofluorene results in increased expression of CCN2 protein Iloprost inhibits the reaction [2-Acetylaminofluorene results in increased expression of CCN2 mRNA] |
CTD |
PMID:15940639 |
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NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CCNA2 protein |
CTD |
PMID:15158336 |
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NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression increases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CCNB1 protein 2-Acetylaminofluorene results in increased expression of CCNB1 mRNA |
CTD |
PMID:15158336 PMID:22584684 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnb2 |
cyclin B2 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of CCNB2 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA] |
CTD |
PMID:17317680 PMID:19167416 PMID:22584684 |
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NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:71,087,595...71,100,874
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA] 2-Acetylaminofluorene results in increased expression of CCND1 mRNA |
CTD |
PMID:14633663 PMID:22584684 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
multiple interactions decreases activity |
EXP |
2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] 2-Acetylaminofluorene results in decreased activity of CCNE1 protein |
CTD |
PMID:10708481 PMID:14633663 |
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NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccng1 |
cyclin G1 |
decreases expression increases expression |
EXP ISO |
2-Acetylaminofluorene results in decreased expression of CCNG1 mRNA 2-Acetylaminofluorene results in increased expression of CCNG1 mRNA |
CTD |
PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 |
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NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641
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G |
Cd276 |
Cd276 molecule |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CD276 mRNA |
CTD |
PMID:17070881 PMID:21784091 |
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NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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G |
Cd44 |
CD44 molecule |
increases expression |
EXP IEP |
2-Acetylaminofluorene results in increased expression of CD44 mRNA; 2-Acetylaminofluorene results in increased expression of CD44 protein 2-Fluorenylacetamide increases CD44 mRNA in liver, and protein in liver and serum |
CTD RGD |
PMID:17187413 PMID:22584684 PMID:33211169 PMID:31966914 |
RGD:25823185 |
NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 protein |
CTD |
PMID:16317707 |
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NCBI chr 8:27,954,292...27,966,935
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdca3 |
cell division cycle associated 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDCA3 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:157,634,928...157,638,799
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G |
Cdh13 |
cadherin 13 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDH13 mRNA |
CTD |
PMID:21784091 |
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NCBI chr19:63,258,251...64,296,122
Ensembl chr19:46,349,430...47,387,459
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G |
Cdh22 |
cadherin 22 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDH22 mRNA |
CTD |
PMID:17187413 |
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NCBI chr 3:174,264,869...174,389,940
Ensembl chr 3:153,845,787...153,970,588
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G |
Cdh3 |
cadherin 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDH3 mRNA |
CTD |
PMID:17187413 |
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NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDK1 mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases activity |
EXP |
2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; 2-Acetylaminofluorene results in decreased localization of and results in decreased phosphorylation of and results in decreased activity of CDK2 protein 2-Acetylaminofluorene results in decreased activity of CDK2 protein |
CTD |
PMID:10708481 PMID:15158336 |
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NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases activity |
EXP |
2-Acetylaminofluorene results in increased activity of CDK4 protein |
CTD |
PMID:15158336 |
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NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
EXP ISO |
2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]] 2-Acetylaminofluorene results in increased expression of CDKN1A mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA] 2-Acetylaminofluorene results in increased expression of CDKN1A mRNA; 2-Acetylaminofluorene results in increased expression of CDKN1A protein |
CTD |
PMID:10708481 PMID:11003613 PMID:14633663 PMID:17070881 PMID:17317680 PMID:17582756 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684 More...
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions |
EXP |
2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; Pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]] |
CTD |
PMID:17582756 |
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NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions increases expression increases methylation |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein 2-Acetylaminofluorene results in increased expression of CDKN2A mRNA 2-Acetylaminofluorene results in increased methylation of CDKN2A gene; 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter |
CTD |
PMID:16317707 PMID:18204080 PMID:19167416 PMID:20188851 PMID:22213190 |
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NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
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G |
Cdkn2b |
cyclin-dependent kinase inhibitor 2B |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of CDKN2B mRNA |
CTD |
PMID:17317680 PMID:22213190 |
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NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:104,010,680...104,019,050
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G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDKN2C mRNA |
CTD |
PMID:22584684 |
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NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:124,411,124...124,416,278
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G |
Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CDKN3 mRNA |
CTD |
PMID:22213190 PMID:22584684 |
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NCBI chr15:22,502,299...22,513,725
Ensembl chr15:20,022,664...20,033,945
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CEBPA protein |
CTD |
PMID:20188851 PMID:21785164 |
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NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions decreases expression |
EXP |
2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter] 2-Acetylaminofluorene results in decreased expression of CEBPB protein |
CTD |
PMID:21785164 |
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NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces2e |
carboxylesterase 2E |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CES2E mRNA |
CTD |
PMID:21607683 |
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NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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G |
Ces3a |
carboxylesterase 3a |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CES3 mRNA |
CTD |
PMID:20713471 |
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NCBI chr19:32,992,386...33,000,562
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G |
Ckmt1 |
creatine kinase, mitochondrial 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CKMT1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:108,330,705...108,335,758
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G |
Cldn4 |
claudin 4 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CLDN4 mRNA |
CTD |
PMID:17187413 |
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NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436
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G |
Cldn7 |
claudin 7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CLDN7 mRNA |
CTD |
PMID:17187413 |
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NCBI chr10:55,188,670...55,190,871
Ensembl chr10:54,689,987...54,692,171
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G |
Clu |
clusterin |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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G |
Cmas |
cytidine monophosphate N-acetylneuraminic acid synthetase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CMAS protein |
CTD |
PMID:6331524 |
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NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125
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G |
Col17a1 |
collagen type XVII alpha 1 chain |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 1:256,472,648...256,518,857
Ensembl chr 1:246,531,367...246,577,632
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G |
Commd3 |
COMM domain containing 3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of COMMD3 mRNA |
CTD |
PMID:17317680 |
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NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177
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G |
Coq6 |
coenzyme Q6 monooxygenase |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of COQ6 mRNA |
CTD |
PMID:16158176 |
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NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
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G |
Cpq |
carboxypeptidase Q |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CPQ mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:64,264,081...64,724,546
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G |
Cps1 |
carbamoyl-phosphate synthase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein |
CTD |
PMID:11813887 |
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NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:68,614,153...68,737,033
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G |
Crebbp |
CREB binding protein |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of CREBBP mRNA |
CTD |
PMID:22213190 |
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NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
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G |
Cryab |
crystallin, alpha B |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CRYAB mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
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G |
Cryl1 |
crystallin, lambda 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CRYL1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CRYL1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr15:35,542,628...35,661,563
Ensembl chr15:31,427,054...31,545,997
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G |
Csta |
cystatin A |
affects expression |
ISO |
2-Acetylaminofluorene affects the expression of CSTA mRNA |
CTD |
PMID:27825931 |
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NCBI chr11:78,125,813...78,136,818
Ensembl chr11:64,620,483...64,631,488
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CXCL1 protein |
CTD |
PMID:25051504 |
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NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CXCL10 protein |
CTD |
PMID:25051504 |
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NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCL12 protein 2-Acetylaminofluorene results in increased expression of CXCL12 mRNA; 2-Acetylaminofluorene results in increased expression of CXCL12 protein |
CTD |
PMID:12626097 PMID:15579440 |
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NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of CXCL2 protein |
CTD |
PMID:25051504 |
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NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of CXCR4 mRNA [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein |
CTD |
PMID:12626097 PMID:15579440 |
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NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases hydrolysis multiple interactions increases expression |
ISO EXP |
CYP1A1 results in increased hydrolysis of 2-Acetylaminofluorene 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA] 2-Acetylaminofluorene analog results in increased expression of CYP1A1 protein; 2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP1A1 protein |
CTD |
PMID:2334931 PMID:10445401 PMID:11888708 PMID:15916741 PMID:20713471 PMID:25224404 More...
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects metabolic processing increases expression decreases expression multiple interactions increases hydrolysis increases activity |
ISO EXP |
CYP1A2 protein affects the metabolism of 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CYP1A2 protein 2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA 2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 protein NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA] CYP1A2 results in increased hydrolysis of 2-Acetylaminofluorene CYP1A2 protein results in increased activity of 2-Acetylaminofluorene |
CTD |
PMID:2334931 PMID:2655891 PMID:15450435 PMID:15916741 PMID:16381673 PMID:28245158 More...
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:17317680 PMID:20713471 |
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NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases expression increases expression |
EXP |
2-Acetylaminofluorene analog results in decreased expression of CYP2B1 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B1 protein 2-Acetylaminofluorene results in increased expression of CYP2B1 protein |
CTD |
PMID:10445401 PMID:15916741 |
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NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
decreases expression |
EXP |
2-Acetylaminofluorene analog results in decreased expression of CYP2B2 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B2 protein |
CTD |
PMID:15916741 |
|
NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2c13 |
cytochrome P450, family 2, subfamily c, polypeptide 13 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CYP2C13 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] 2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein; 2-Acetylaminofluorene results in increased expression of CYP2E1 protein |
CTD |
PMID:14656948 PMID:15916741 PMID:16158176 PMID:17393424 PMID:23665045 |
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NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CYP3A2 protein |
CTD |
PMID:10445401 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 protein [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP3A23-3A1 mRNA; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]; Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] |
CTD |
PMID:12504080 PMID:14656948 PMID:16158176 |
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NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp4f5 |
cytochrome P450, family 4, subfamily f, polypeptide 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of CYP4F5 mRNA |
CTD |
PMID:17070881 |
|
NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
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G |
Dap |
death-associated protein |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:82,199,280...82,251,752
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G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DDAH1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of DDIT4L mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:226,128,276...226,131,375
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G |
Ddr1 |
discoidin domain receptor tyrosine kinase 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DDR1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,044,320...3,064,468
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G |
Des |
desmin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DES mRNA |
CTD |
PMID:17187413 |
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NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699
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G |
Dhodh |
dihydroorotate dehydrogenase |
decreases activity |
EXP |
2-Acetylaminofluorene results in decreased activity of DHODH protein |
CTD |
PMID:6331524 |
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NCBI chr19:54,460,636...54,483,049
Ensembl chr19:37,558,177...37,591,654
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of DLK1 mRNA; 2-Acetylaminofluorene results in increased expression of DLK1 protein |
CTD |
PMID:15567716 PMID:17187413 PMID:17538966 |
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NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:128,410,316...128,417,522
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G |
Dmp1 |
dentin matrix acidic phosphoprotein 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of DMP1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr14:5,833,111...5,867,154
Ensembl chr14:5,528,431...5,539,323
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression increases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of E2F1 protein 2-Acetylaminofluorene results in increased expression of E2F1 mRNA |
CTD |
PMID:15158336 PMID:19167416 PMID:22213190 |
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NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f3 |
E2F transcription factor 3 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of E2F3 protein |
CTD |
PMID:15158336 PMID:19167416 |
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NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,601,830...34,676,253
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G |
E2f4 |
E2F transcription factor 4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of E2F4 protein |
CTD |
PMID:15158336 |
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NCBI chr19:50,084,335...50,091,731
Ensembl chr19:33,174,410...33,181,806
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G |
Eda2r |
ectodysplasin A2 receptor |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EDA2R mRNA |
CTD |
PMID:21607683 |
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NCBI chr X:66,225,557...66,280,674
Ensembl chr X:62,228,229...62,269,268
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G |
Egf |
epidermal growth factor |
decreases localization multiple interactions |
EXP |
2-Acetylaminofluorene results in decreased localization of EGF protein 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:10900465 |
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NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases expression |
EXP |
2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] 2-Acetylaminofluorene results in decreased expression of EGFR mRNA |
CTD |
PMID:10900465 PMID:22213190 |
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NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of EGR1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
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G |
Ei24 |
EI24, autophagy associated transmembrane protein |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:36,494,289...36,510,571
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G |
Emp2 |
epithelial membrane protein 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EMP2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr10:5,866,869...5,901,533
Ensembl chr10:5,360,073...5,394,733
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G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ENC1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:28,550,464...28,562,713
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G |
Eno1 |
enolase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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G |
Epcam |
epithelial cell adhesion molecule |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of EPCAM mRNA |
CTD |
PMID:17070881 PMID:17187413 |
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NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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G |
Epha1 |
Eph receptor A1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EPHA1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:71,246,409...71,260,846
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of EPHX1 mRNA |
CTD |
PMID:17070881 PMID:17317680 PMID:21607683 |
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NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ERBB2 protein |
CTD |
PMID:11350689 |
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NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ESR1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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G |
Exoc4 |
exocyst complex component 4 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of EXOC4 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723
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G |
Fam110a |
family with sequence similarity 110, member A |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of FAM110A mRNA |
CTD |
PMID:21607683 |
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NCBI chr 3:140,474,484...140,485,074
Ensembl chr 3:140,474,249...140,485,093
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G |
Fas |
Fas cell surface death receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of FAS mRNA |
CTD |
PMID:17070881 PMID:22584684 |
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NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G |
Fbxw9 |
F-box and WD repeat domain containing 9 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of FBXW9 mRNA |
CTD |
PMID:21607683 |
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NCBI chr19:39,995,408...40,002,312
Ensembl chr19:23,090,534...23,097,439
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G |
Fhit |
fragile histidine triad diadenosine triphosphatase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of FHIT mRNA |
CTD |
PMID:17070881 |
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NCBI chr15:16,365,401...17,872,901
Ensembl chr15:13,934,995...15,442,340
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G |
Flt3 |
Fms related receptor tyrosine kinase 3 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of FLT3 mRNA |
CTD |
PMID:18031378 |
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NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474
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G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of FN1 mRNA |
CTD |
PMID:15940639 |
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NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein] |
CTD |
PMID:17696247 |
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NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of FTH1 protein |
CTD |
PMID:21785164 |
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NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein] |
CTD |
PMID:15554553 |
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NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804
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G |
Gaa |
alpha glucosidase |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GAA mRNA |
CTD |
PMID:17317680 |
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NCBI chr10:105,028,106...105,045,365
Ensembl chr10:104,529,747...104,546,836
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G |
Gas2l3 |
growth arrest-specific 2 like 3 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNA |
CTD |
PMID:20713471 |
|
NCBI chr 7:25,690,929...25,726,806
Ensembl chr 7:23,806,310...23,836,411
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G |
Gcgr |
glucagon receptor |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCGR mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCGR mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr10:106,306,803...106,314,970
Ensembl chr10:105,808,473...105,816,640
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of GCLC mRNA [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA |
CTD |
PMID:14656948 PMID:16158176 PMID:16426233 |
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NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA |
CTD |
PMID:16158176 |
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NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GDF15 mRNA |
CTD |
PMID:21607683 |
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NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of GGT1 mRNA [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein] |
CTD |
PMID:15554553 PMID:17187413 |
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NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GJA1 mRNA; 2-Acetylaminofluorene results in increased expression of GJA1 protein |
CTD |
PMID:15133858 PMID:17187413 |
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NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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G |
Gjb1 |
gap junction protein, beta 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of GJB1 mRNA |
CTD |
PMID:2559087 |
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NCBI chr X:70,541,845...70,549,776
Ensembl chr X:66,501,820...66,509,925
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G |
Gjb2 |
gap junction protein, beta 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GJB2 mRNA |
CTD |
PMID:22213190 |
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NCBI chr15:35,375,977...35,393,817
Ensembl chr15:31,260,357...31,278,177
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G |
Glrx3 |
glutaredoxin 3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GLRX3 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010
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G |
Gpc3 |
glypican 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GPC3 mRNA |
CTD |
PMID:17187413 |
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NCBI chr X:136,789,770...137,157,598
Ensembl chr X:131,868,990...132,236,798
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877
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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of GRIA3 mRNA |
CTD |
PMID:17070881 PMID:21607683 |
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NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096
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G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GRINA mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity decreases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein] |
CTD |
PMID:16158176 PMID:23665045 PMID:26364502 |
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NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GSS mRNA |
CTD |
PMID:17317680 |
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NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions increases expression |
EXP ISO |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTA2 mRNA 2-Acetylaminofluorene results in increased expression of GSTA2 mRNA |
CTD |
PMID:14656948 PMID:16158176 PMID:17317680 |
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NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GSTA1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of GSTM1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein] 2-Acetylaminofluorene results in increased expression of GSTP1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTP1 protein |
CTD |
PMID:12497209 PMID:12781041 PMID:12907702 PMID:15554553 PMID:17393424 PMID:18271918 PMID:21785164 PMID:22213190 More...
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NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of GTSE1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
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G |
H2ax |
H2A.X variant histone |
increases expression increases phosphorylation |
EXP ISO |
2-Acetylaminofluorene results in increased expression of H2AX protein 2-Acetylaminofluorene results in increased phosphorylation of H2AX protein |
CTD |
PMID:26338220 PMID:34510228 |
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NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNA |
CTD |
PMID:16158176 |
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NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions decreases expression |
EXP |
2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter] 2-Acetylaminofluorene results in decreased expression of HAMP mRNA |
CTD |
PMID:21785164 |
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NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891
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G |
Hebp2 |
heme binding protein 2 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 1:15,014,729...15,021,523
Ensembl chr 1:13,194,982...13,201,777
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA; beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] |
CTD |
PMID:20435455 |
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NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of HMOX1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Hras |
HRas proto-oncogene, GTPase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of HRAS protein |
CTD |
PMID:11350689 |
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NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd17b6 |
hydroxysteroid (17-beta) dehydrogenase 6 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of HSD17B6 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:831,407...850,950
Ensembl chr 7:422,480...442,425
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G |
Ica1 |
islet cell autoantigen 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ICA1 mRNA |
CTD |
PMID:21784091 |
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NCBI chr 4:37,622,759...37,771,055
Ensembl chr 4:36,656,475...36,804,298
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G |
Id1 |
inhibitor of DNA binding 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ID1 mRNA |
CTD |
PMID:15120964 |
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NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419
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G |
Ifna1 |
interferon, alpha 1 |
multiple interactions |
EXP |
IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] |
CTD |
PMID:14633663 |
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NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifna2 |
interferon alpha 2 |
multiple interactions |
EXP |
IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:11915028 PMID:15368444 |
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NCBI chr 5:103,258,617...103,259,195
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein] |
CTD |
PMID:14736494 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf2 |
insulin-like growth factor 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IGF2 mRNA |
CTD |
PMID:22213190 |
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NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
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G |
Igfals |
insulin-like growth factor binding protein, acid labile subunit |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of IGFALS mRNA |
CTD |
PMID:21607683 |
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NCBI chr10:14,397,076...14,408,439
Ensembl chr10:13,898,395...13,902,677
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases activity |
ISO |
2-Acetylaminofluorene results in increased activity of IKBKB protein |
CTD |
PMID:11960367 |
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NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
affects expression |
EXP |
2-Acetylaminofluorene affects the expression of IL10 protein |
CTD |
PMID:25051504 |
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NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IL12B protein |
CTD |
PMID:25051504 |
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NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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G |
Il1b |
interleukin 1 beta |
multiple interactions affects expression increases expression |
ISO EXP |
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 2-Acetylaminofluorene affects the expression of IL1B mRNA 2-Acetylaminofluorene results in increased expression of IL1B protein |
CTD |
PMID:14670622 PMID:25051504 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IL2RA mRNA |
CTD |
PMID:17070881 |
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NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
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G |
Il33 |
interleukin 33 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of IL33 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
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G |
Il5 |
interleukin 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of IL5 protein |
CTD |
PMID:25051504 |
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NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of IL6 protein |
CTD |
PMID:25051504 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb4 |
integrin subunit beta 4 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of ITGB4 mRNA |
CTD |
PMID:17317680 |
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NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,206,665...101,243,012
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein] |
CTD |
PMID:17696247 |
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NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G |
Kdm6a |
lysine demethylase 6A |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of KDM6A mRNA |
CTD |
PMID:22213190 |
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NCBI chr X:6,920,374...7,060,027
Ensembl chr X:4,337,750...4,477,062
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G |
Kif11 |
kinesin family member 11 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of KIF11 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of KIT protein |
CTD |
PMID:15133858 |
|
NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652
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G |
Krt14 |
keratin 14 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of KRT14 protein |
CTD |
PMID:33211169 |
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NCBI chr10:85,638,182...85,642,450
Ensembl chr10:85,066,802...85,171,799
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G |
Krt15 |
keratin 15 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of KRT15 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,066,802...85,171,799
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G |
Krt19 |
keratin 19 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of KRT19 mRNA; 2-Acetylaminofluorene results in increased expression of KRT19 protein [Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of KRT19 protein |
CTD |
PMID:15133858 PMID:17187413 PMID:17661067 |
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NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,066,802...85,171,799
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G |
Krt20 |
keratin 20 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of KRT20 mRNA |
CTD |
PMID:17317680 |
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NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107
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G |
Krt23 |
keratin 23 |
multiple interactions increases expression |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983
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G |
Krt4 |
keratin 4 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of KRT4 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 7:133,046,067...133,052,027
Ensembl chr 7:133,046,515...133,052,019
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G |
Krt8 |
keratin 8 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728
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G |
Lep |
leptin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of LEP protein |
CTD |
PMID:25051504 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Lig4 |
DNA ligase 4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of LIG4 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040
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G |
Ly6d |
lymphocyte antigen 6 family member D |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of LY6D mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
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G |
Ly6e |
lymphocyte antigen 6 family member E |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of LY6E mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:106,935,761...106,939,689
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G |
Lypd3 |
Ly6/Plaur domain containing 3 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
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G |
Lzic |
leucine zipper and CTNNBIP1 domain containing |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of LZIC mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 5:159,928,260...159,941,512
Ensembl chr 5:159,920,439...159,939,685
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G |
Mal |
mal, T-cell differentiation protein |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of MAL mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
2-Acetylaminofluorene affects the phosphorylation of and affects the activity of MAPK8 protein |
CTD |
PMID:17546627 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G |
Mat1a |
methionine adenosyltransferase 1A |
affects acetylation decreases expression affects methylation |
EXP |
2-Acetylaminofluorene affects the acetylation of MAT1A exon; 2-Acetylaminofluorene affects the acetylation of MAT1A promoter 2-Acetylaminofluorene results in decreased expression of MAT1A mRNA 2-Acetylaminofluorene affects the methylation of MAT1A exon; 2-Acetylaminofluorene affects the methylation of MAT1A promoter |
CTD |
PMID:22213190 |
|
NCBI chr16:17,017,168...17,035,368
Ensembl chr16:16,983,022...17,001,274
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G |
Matn2 |
matrilin 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MATN2 mRNA; 2-Acetylaminofluorene results in increased expression of MATN2 protein |
CTD |
PMID:17513098 |
|
NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:65,494,834...65,645,113
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G |
Mbl2 |
mannose binding lectin 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of MBL2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 1:237,429,873...237,465,567
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G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein 2-Acetylaminofluorene results in increased expression of MDM2 mRNA; 2-Acetylaminofluorene results in increased expression of MDM2 protein |
CTD |
PMID:11003613 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684 |
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NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
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G |
Meg3 |
maternally expressed 3 |
decreases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in decreased expression of MEG3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 6:134,274,056...134,306,249
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression decreases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MGMT mRNA 2-Acetylaminofluorene results in decreased expression of MGMT mRNA |
CTD |
PMID:17070881 PMID:22213190 |
|
NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
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G |
Mgst2 |
microsomal glutathione S-transferase 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:135,693,557...135,715,828
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G |
Mir106b |
microRNA 106b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR106B mRNA |
CTD |
PMID:19167416 |
|
NCBI chr12:22,157,053...22,157,134
Ensembl chr12:17,043,344...17,043,425
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G |
Mir125b1 |
microRNA 125b-1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR125B-1 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:41,952,966...41,953,052
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G |
Mir130b |
microRNA 130b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR130B mRNA |
CTD |
PMID:19167416 |
|
NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
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G |
Mir132 |
microRNA 132 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR132 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,023,696...60,023,796
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G |
Mir146b |
microRNA 146b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR146B mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 1:255,144,860...255,144,947
Ensembl chr 1:245,203,438...245,203,525
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G |
Mir155 |
microRNA 155 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR155 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718
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G |
Mir17 |
microRNA 17 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR17; 2-Acetylaminofluorene results in increased expression of MIR17 mRNA |
CTD |
PMID:19167416 PMID:20188851 |
|
NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712
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G |
Mir181b2 |
microRNA 181b-2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR181B-2 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 3:43,026,666...43,026,753
Ensembl chr 3:22,616,948...22,617,035
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G |
Mir181c |
microRNA 181c |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR181C mRNA |
CTD |
PMID:19167416 |
|
NCBI chr19:40,888,291...40,888,396
Ensembl chr19:23,983,523...23,983,628
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G |
Mir182 |
microRNA 182 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR182 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 4:59,752,246...59,752,307
Ensembl chr 4:58,784,818...58,784,879
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G |
Mir185 |
microRNA 185 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR185 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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G |
Mir18a |
microRNA 18a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR18A; 2-Acetylaminofluorene results in increased expression of MIR18A mRNA |
CTD |
PMID:19167416 PMID:20188851 |
|
NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860
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G |
Mir200a |
microRNA 200a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR200A mRNA |
CTD |
PMID:19167416 PMID:22584684 |
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NCBI chr 5:171,930,717...171,930,805
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G |
Mir200b |
microRNA 200b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR200B mRNA |
CTD |
PMID:19167416 PMID:22584684 |
|
NCBI chr 5:171,931,495...171,931,589
Ensembl chr 5:166,649,272...166,649,366
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G |
Mir200c |
microRNA 200c |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR200C mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 4:159,209,965...159,210,033
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G |
Mir202 |
microRNA 202 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR202 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 1:204,184,345...204,184,416
Ensembl chr 1:194,754,730...194,754,801
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G |
Mir203-2 |
microRNA 203-2 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR203 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 6:137,020,691...137,020,805
Ensembl chr 6:131,199,542...131,199,656
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G |
Mir204 |
microRNA 204 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR204 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:220,316,931...220,317,040
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G |
Mir205 |
microRNA 205 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR205 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr13:107,564,535...107,564,642
Ensembl chr13:105,035,878...105,035,985
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G |
Mir20a |
microRNA 20a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR20A; 2-Acetylaminofluorene results in increased expression of MIR20A mRNA |
CTD |
PMID:19167416 PMID:20188851 |
|
NCBI chr15:98,588,303...98,588,387
Ensembl chr15:92,181,084...92,181,168
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G |
Mir21 |
microRNA 21 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR21 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
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G |
Mir214 |
microRNA 214 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR214 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr13:77,121,645...77,121,752
Ensembl chr13:74,588,372...74,588,481
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G |
Mir22 |
microRNA 22 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR22 mRNA |
CTD |
PMID:22213190 |
|
NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133
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G |
Mir221 |
microRNA 221 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR221 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr X:6,023,182...6,023,290
Ensembl chr X:3,429,465...3,429,573
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G |
Mir293 |
microRNA 293 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR293 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 1:74,878,457...74,878,528
Ensembl chr 1:65,963,050...65,963,121
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G |
Mir31 |
microRNA 31 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR31; 2-Acetylaminofluorene results in increased expression of MIR31 mRNA |
CTD |
PMID:19167416 PMID:20188851 |
|
NCBI chr 5:108,714,849...108,714,954
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|
G |
Mir34a |
microRNA 34a |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR34A mRNA |
CTD |
PMID:19167416 PMID:22584684 |
|
NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103
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G |
Mir382 |
microRNA 382 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR382 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 6:128,748,539...128,748,618
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|
G |
Mir410 |
microRNA 410 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR410 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
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G |
Mir429 |
microRNA 429 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR429 mRNA |
CTD |
PMID:19167416 PMID:22584684 |
|
NCBI chr 5:171,929,682...171,929,766
Ensembl chr 5:166,647,459...166,647,543
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G |
Mir490 |
microRNA 490 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR490 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 4:66,014,586...66,014,669
Ensembl chr 4:65,047,548...65,047,631
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G |
Mir93 |
microRNA 93 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR93; 2-Acetylaminofluorene results in increased expression of MIR93 mRNA |
CTD |
PMID:19167416 PMID:20188851 |
|
NCBI chr12:22,156,844...22,156,930
Ensembl chr12:17,043,135...17,043,221
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G |
Mir96 |
microRNA 96 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIR96 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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G |
Mir99a |
microRNA 99a |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of MIR99A mRNA |
CTD |
PMID:19167416 PMID:22584684 |
|
NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
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G |
Mirlet7b |
microRNA let-7b |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIRLET7B mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:116,804,186...116,804,270
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G |
Mirlet7c1 |
microRNA let-7c-1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIRLET7C-1 mRNA |
CTD |
PMID:19167416 |
|
NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
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G |
Mirlet7i |
microRNA let-7i |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MIRLET7I mRNA |
CTD |
PMID:19167416 |
|
NCBI chr 7:60,527,877...60,527,961
Ensembl chr 7:58,642,480...58,642,571
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions increases expression |
EXP ISO |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein] 2-Acetylaminofluorene results in increased expression of MKI67 mRNA |
CTD |
PMID:15565650 PMID:17317680 PMID:17393424 PMID:23665045 PMID:26338220 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MMP2 mRNA |
CTD |
PMID:18678246 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MMP9 mRNA |
CTD |
PMID:18678246 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt1 |
metallothionein 1 |
multiple interactions increases expression |
EXP |
Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MT1A protein] |
CTD |
PMID:15565650 |
|
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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G |
Mthfr |
methylenetetrahydrofolate reductase |
decreases expression decreases methylation |
EXP |
2-Acetylaminofluorene results in decreased expression of MTHFR mRNA 2-Acetylaminofluorene results in decreased methylation of MTHFR promoter |
CTD |
PMID:22213190 |
|
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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G |
Muc1 |
mucin 1, cell surface associated |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of MUC1 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:174,635,995...174,640,733
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G |
Mybl1 |
MYB proto-oncogene like 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of MYBL1 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:9,582,934...9,618,183
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases mutagenesis increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein] 2-Acetylaminofluorene results in increased mutagenesis of MYC gene 2-Acetylaminofluorene results in increased expression of MYC protein |
CTD |
PMID:11350689 PMID:17696247 PMID:19167416 PMID:20188851 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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G |
Nampt |
nicotinamide phosphoribosyltransferase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of NAMPT mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
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G |
Nat1 |
N-acetyltransferase 1 |
increases activity |
ISO |
NAT1 protein results in increased activity of 2-Acetylaminofluorene |
CTD |
PMID:15450435 |
|
NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
increases activity |
ISO |
NAT2 protein results in increased activity of 2-Acetylaminofluorene |
CTD |
PMID:15450435 |
|
NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520
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|
G |
Nek6 |
NIMA-related kinase 6 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of NEK6 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:22,284,279...22,395,990
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression increases activity |
ISO |
2-Acetylaminofluorene results in increased expression of NFE2L2 mRNA 2-Acetylaminofluorene results in increased activity of NFE2L2 protein |
CTD |
PMID:21607683 PMID:30114225 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases localization |
ISO |
[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] 2-Acetylaminofluorene results in increased localization of NFKB1 protein Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of NFKB1 protein] |
CTD |
PMID:11960367 PMID:17303067 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18404532 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions increases degradation |
EXP |
[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein 2-Acetylaminofluorene results in increased degradation of NFKBIB protein |
CTD |
PMID:11020383 |
|
NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862
|
|
G |
Ninj1 |
ninjurin 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of NINJ1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NINJ1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,452,813...15,461,704
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein] |
CTD |
PMID:23665045 PMID:26364502 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of NOS3 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch1 |
notch receptor 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
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Nprl2 |
NPR2-like, GATOR1 complex subunit |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of NPRL2 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 8:117,094,443...117,097,639
Ensembl chr 8:108,215,814...108,218,996
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of NQO1 mRNA |
CTD |
PMID:21607683 PMID:22213190 |
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of NR1I2 mRNA NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA] |
CTD |
PMID:12504080 PMID:16381673 |
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NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
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G |
Nudcd2 |
NudC domain containing 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of NUDCD2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738
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G |
Nudt7 |
nudix hydrolase 7 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of NUDT7 mRNA |
CTD |
PMID:21607683 |
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NCBI chr19:59,034,808...59,049,148
Ensembl chr19:42,125,711...42,151,081
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of NUPR1 mRNA |
CTD |
PMID:17070881 PMID:22584684 |
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NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
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G |
Nusap1 |
nucleolar and spindle associated protein 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of NUSAP1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624
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G |
Ociad2 |
OCIA domain containing 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of OCIAD2 mRNA |
CTD |
PMID:17317680 |
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NCBI chr14:35,225,291...35,243,306
Ensembl chr14:34,873,820...34,889,265
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G |
Olfm1 |
olfactomedin 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of OLFM1 mRNA |
CTD |
PMID:20713471 |
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NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:11,520,729...11,558,239
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G |
Osm |
oncostatin M |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of OSM mRNA |
CTD |
PMID:15743783 PMID:18678246 |
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NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313
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G |
Osmr |
oncostatin M receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of OSMR mRNA |
CTD |
PMID:15743783 |
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NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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G |
Padi2 |
peptidyl arginine deiminase 2 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 5:158,492,087...158,534,662
Ensembl chr 5:153,209,053...153,251,632
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PCK1 mRNA |
CTD |
PMID:16510358 |
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NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein] |
CTD |
PMID:16352317 PMID:17393424 PMID:19167416 PMID:23665045 PMID:26364502 |
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NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PECAM1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116
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G |
Perp |
p53 apoptosis effector related to PMP22 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:13,542,067...13,554,511
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of PHLDA3 mRNA |
CTD |
PMID:17070881 PMID:21607683 PMID:22584684 |
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NCBI chr13:49,745,003...49,748,088
Ensembl chr13:47,193,086...47,196,335
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G |
Phyh |
phytanoyl-CoA 2-hydroxylase |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of PHYH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of PHYH mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr17:78,238,747...78,255,645
Ensembl chr17:73,329,082...73,346,409
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G |
Piga |
phosphatidylinositol glycan anchor biosynthesis, class A |
increases mutagenesis |
EXP |
2-Acetylaminofluorene results in increased mutagenesis of PIGA |
CTD |
PMID:22923490 |
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NCBI chr X:33,672,832...33,687,747
Ensembl chr X:30,042,343...30,055,804
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G |
Pkd1 |
polycystin 1, transient receptor potential channel interacting |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PKD1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr10:14,077,733...14,125,682
Ensembl chr10:13,573,021...13,621,128
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G |
Pkm |
pyruvate kinase M1/2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PKM mRNA; 2-Acetylaminofluorene results in increased expression of PKM protein |
CTD |
PMID:17538966 |
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NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
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G |
Pkp1 |
plakophilin 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PKP1 mRNA |
CTD |
PMID:17317680 |
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NCBI chr13:49,861,340...49,909,162
Ensembl chr13:47,309,614...47,357,465
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G |
Plk2 |
polo-like kinase 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PLK2 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA] |
CTD |
PMID:17317680 PMID:19167416 |
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NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429
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G |
Polk |
DNA polymerase kappa |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of POLK mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:27,822,679...27,882,313
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G |
Por |
cytochrome p450 oxidoreductase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of POR mRNA |
CTD |
PMID:15089088 |
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NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
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G |
Prc1 |
protein regulator of cytokinesis 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PRC1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:134,250,081...134,271,765
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G |
Prkch |
protein kinase C, eta |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:92,292,000...92,490,654
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G |
Prom1 |
prominin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PROM1 mRNA |
CTD |
PMID:17187413 |
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NCBI chr14:71,202,303...71,307,008
Ensembl chr14:66,990,160...67,094,527
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G |
Prox1 |
prospero homeobox 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PROX1 mRNA |
CTD |
PMID:22213190 |
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NCBI chr13:104,196,615...104,251,007
Ensembl chr13:101,669,184...101,711,183
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G |
Psmd10 |
proteasome 26S subunit, non-ATPase 10 |
increases expression multiple interactions |
EXP |
2-Acetylaminofluorene results in increased expression of PSMD10 protein RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein] |
CTD |
PMID:16448463 |
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NCBI chr X:104,656,809...104,665,122
Ensembl chr X:104,656,812...104,665,097
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G |
Psrc1 |
proline and serine rich coiled-coil 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PSRC1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 2:198,710,427...198,715,001
Ensembl chr 2:196,022,361...196,026,874
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G |
Pten |
phosphatase and tensin homolog |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of PTEN protein |
CTD |
PMID:19167416 |
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NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgr1 |
prostaglandin reductase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA |
CTD |
PMID:16158176 |
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NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:73,784,009...73,802,666
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein] |
CTD |
PMID:23665045 PMID:26364502 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Ptn |
pleiotrophin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PTN mRNA |
CTD |
PMID:12057922 |
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NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:65,293,734...65,375,456
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G |
Ptp4a3 |
protein tyrosine phosphatase 4A3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PTP4A3 mRNA |
CTD |
PMID:17317680 |
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NCBI chr 7:107,518,220...107,549,949
Ensembl chr 7:105,628,029...105,660,919
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G |
Ptprc |
protein tyrosine phosphatase, receptor type, C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PTPRC mRNA |
CTD |
PMID:17187413 |
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NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692
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G |
Pttg1 |
PTTG1 regulator of sister chromatid separation, securin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of PTTG1 mRNA |
CTD |
PMID:19167416 |
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NCBI chr10:28,394,940...28,406,410
Ensembl chr10:27,893,689...27,904,837
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G |
Pvt1 |
Pvt1 oncogene |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of PVT1 mRNA |
CTD |
PMID:21607683 |
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NCBI chr 7:95,545,916...95,769,306
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G |
Rac1 |
Rac family small GTPase 1 |
increases activity multiple interactions |
ISO |
2-Acetylaminofluorene results in increased activity of RAC1 protein [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA |
CTD |
PMID:11960367 |
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NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251
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G |
Rassf1 |
Ras association domain family member 1 |
increases methylation |
EXP |
2-Acetylaminofluorene results in increased methylation of RASSF1 promoter |
CTD |
PMID:20188851 |
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NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:108,225,023...108,236,164
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G |
Rb1 |
RB transcriptional corepressor 1 |
affects phosphorylation multiple interactions |
EXP |
2-Acetylaminofluorene affects the phosphorylation of RB1 protein 2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein] |
CTD |
PMID:15158336 PMID:16448463 |
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NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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G |
Rbx1 |
ring-box 1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RBX1 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:112,990,835...113,001,051
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases activity increases expression multiple interactions increases localization |
ISO EXP |
2-Acetylaminofluorene results in increased activity of RELA protein 2-Acetylaminofluorene results in increased expression of RELA protein geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA] 2-Acetylaminofluorene results in increased localization of RELA protein [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA] 2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein] |
CTD |
PMID:11020383 PMID:11960367 PMID:14670622 PMID:17303067 PMID:26364502 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Rgn |
regucalcin |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of RGN mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of RGN mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr X:4,172,537...4,190,112
Ensembl chr X:1,619,032...1,634,450
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G |
Rgs2 |
regulator of G-protein signaling 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of RGS2 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385
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G |
Rhbdf2 |
rhomboid 5 homolog 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RHBDF2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr10:102,331,991...102,359,117
Ensembl chr10:101,833,157...101,860,283
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G |
Rhob |
ras homolog family member B |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of RHOB mRNA |
CTD |
PMID:22584684 |
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NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
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G |
Rhobtb2 |
Rho-related BTB domain containing 2 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr15:51,278,024...51,298,209
Ensembl chr15:44,870,376...44,888,651
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RIPK3 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121
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G |
Ripk4 |
receptor-interacting serine-threonine kinase 4 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RIPK4 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr11:37,122,555...37,144,799
Ensembl chr11:37,122,565...37,144,799
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G |
Ros1 |
ROS proto-oncogene 1 , receptor tyrosine kinase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ROS1 mRNA |
CTD |
PMID:17187413 |
|
NCBI chr20:31,975,328...32,126,675
Ensembl chr20:31,432,637...31,583,865
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G |
Rplp0 |
ribosomal protein lateral stalk subunit P0 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of RPLP0 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of RPLP0 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr12:46,715,121...46,718,390
Ensembl chr12:41,054,179...41,057,632
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G |
Rprm |
reprimo, TP53 dependent G2 arrest mediator homolog |
multiple interactions increases expression decreases expression |
ISO EXP |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA] 2-Acetylaminofluorene results in increased expression of RPRM mRNA 2-Acetylaminofluorene results in decreased expression of RPRM mRNA |
CTD |
PMID:17317680 PMID:19167416 PMID:22584684 |
|
NCBI chr 3:58,948,618...58,950,035
Ensembl chr 3:38,539,581...38,540,998
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G |
Rps27l |
ribosomal protein S27-like |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RPS27L mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 8:76,443,658...76,448,593
Ensembl chr 8:67,562,483...67,567,418 Ensembl chr12:67,562,483...67,567,418 Ensembl chr 2:67,562,483...67,567,418
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G |
Rrm1 |
ribonucleotide reductase catalytic subunit M1 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RRM1 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261
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G |
Rrm2b |
ribonucleotide reductase regulatory TP53 inducible subunit M2B |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of RRM2B mRNA |
CTD |
PMID:21704725 |
|
NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:69,078,291...69,108,633
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G |
Rsad2 |
radical S-adenosyl methionine domain containing 2 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of RSAD2 mRNA |
CTD |
PMID:20713471 |
|
NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
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G |
S100a11 |
S100 calcium binding protein A11 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of S100A11 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:179,191,715...179,197,044
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G |
S100a14 |
S100 calcium binding protein A14 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of S100A14 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 2:178,305,976...178,308,004
Ensembl chr 2:176,008,395...176,010,423
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G |
Scarb2 |
scavenger receptor class B, member 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SCARB2 mRNA |
CTD |
PMID:17317680 |
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NCBI chr14:15,842,583...15,894,123
Ensembl chr14:15,558,236...15,609,813
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G |
Scpep1 |
serine carboxypeptidase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SCPEP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SCPEP1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr10:74,200,491...74,230,107
Ensembl chr10:73,703,278...73,732,850
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G |
Sctr |
secretin receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SCTR mRNA |
CTD |
PMID:17187413 |
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NCBI chr13:33,680,562...33,744,049
Ensembl chr13:31,127,858...31,180,189
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G |
Serpina7 |
serpin family A member 7 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA |
CTD |
PMID:17070881 |
|
NCBI chr X:107,452,044...107,510,958
Ensembl chr X:102,663,405...102,669,040
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G |
Serpinb5 |
serpin family B member 5 |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr13:23,500,203...23,520,401
Ensembl chr13:22,985,557...23,005,756
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G |
Serpinf1 |
serpin family F member 1 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SERPINF1 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646
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G |
Sesn2 |
sestrin 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SESN2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260
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G |
Sfn |
stratifin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SFN mRNA |
CTD |
PMID:19167416 PMID:22213190 |
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NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314
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G |
Sirt1 |
sirtuin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SIRT1 protein |
CTD |
PMID:19167416 |
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NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
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G |
Slc15a5 |
solute carrier family 15, member 5 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SLC15A5 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 4:170,878,021...170,971,620
Ensembl chr 4:170,878,021...170,971,620
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G |
Slc16a10 |
solute carrier family 16 member 10 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SLC16A10 mRNA |
CTD |
PMID:17070881 |
|
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
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G |
Slc25a4 |
solute carrier family 25 member 4 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733
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G |
Slc2a8 |
solute carrier family 2 member 8 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464
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G |
Slc40a1 |
solute carrier family 40 member 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA |
CTD |
PMID:21785164 |
|
NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:48,033,526...48,051,481
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1A4 mRNA |
CTD |
PMID:16158176 |
|
NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1B2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SLCO1B2 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:15368444 |
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NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:15368444 |
|
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
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G |
Smad4 |
SMAD family member 4 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA |
CTD |
PMID:22213190 |
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NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438
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G |
Smo |
smoothened, frizzled class receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SMO mRNA |
CTD |
PMID:17187413 |
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NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829
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G |
Sncg |
synuclein, gamma |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SNCG mRNA |
CTD |
PMID:22213190 |
|
NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
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G |
Sntg2 |
syntrophin, gamma 2 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SNTG2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 6:46,801,893...47,003,390
Ensembl chr 6:46,801,377...47,003,372
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G |
Socs1 |
suppressor of cytokine signaling 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SOCS1 mRNA |
CTD |
PMID:22213190 |
|
NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein |
CTD |
PMID:17761372 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein; O-(Chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] |
CTD |
PMID:17761372 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox4 |
SRY-box transcription factor 4 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SOX4 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,667,537...35,673,665
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G |
Spg7 |
SPG7 matrix AAA peptidase subunit, paraplegin |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SPG7 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SPG7 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
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NCBI chr19:51,117,088...51,151,228
Ensembl chr19:51,117,057...51,150,484
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G |
Spink1 |
serine peptidase inhibitor, Kazal type 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr18:36,121,626...36,133,596
Ensembl chr18:35,824,550...35,882,642
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G |
Sprr1a |
small proline-rich protein 1A |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SPRR1A mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 2:180,750,709...180,752,625
Ensembl chr 2:178,055,096...178,057,063
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G |
Sprr2f |
small proline rich protein 2F |
increases expression multiple interactions |
ISO |
2-Acetylaminofluorene results in increased expression of SPRR2F mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr 2:177,989,974...177,990,204
Ensembl chr 2:177,989,974...177,990,204
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G |
Sptlc2 |
serine palmitoyltransferase, long chain base subunit 2 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of SPTLC2 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 6:112,679,623...112,762,470
Ensembl chr 6:106,950,949...107,031,542
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G |
Sst |
somatostatin |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of SST protein |
CTD |
PMID:16534498 |
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NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173
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G |
St3gal3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810
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G |
St3gal5 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of ST3GAL5 protein |
CTD |
PMID:6331524 |
|
NCBI chr 4:104,134,613...104,192,558
Ensembl chr 4:104,134,613...104,192,558
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein; Dexamethasone inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein] |
CTD |
PMID:12957465 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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G |
Steap3 |
STEAP3 metalloreductase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
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G |
Stmn1 |
stathmin 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of STMN1 mRNA |
CTD |
PMID:22584684 |
|
NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154
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G |
Sugct |
succinylCoA:glutarate-CoA transferase |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SUGCT mRNA |
CTD |
PMID:17070881 |
|
NCBI chr17:52,072,012...52,929,852
Ensembl chr17:47,376,521...48,234,376
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G |
Sulf2 |
sulfatase 2 |
increases expression |
EXP ISO |
2-Acetylaminofluorene results in increased expression of SULF2 mRNA |
CTD |
PMID:17070881 PMID:21607683 |
|
NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:154,822,085...154,904,415
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G |
Sult1c2a |
sulfotransferase family 1C member 2A |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of SULT1C2 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:6,874,249...6,904,734
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G |
Sult1e1 |
sulfotransferase family 1E member 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,422,324...20,439,275
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNA |
CTD |
PMID:17070881 |
|
NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134
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G |
Taldo1 |
transaldolase 1 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TALDO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TALDO1 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
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G |
Tceal9 |
transcription elongation factor A like 9 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TCEAL9 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TCEAL9 mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr X:104,037,274...104,039,345
Ensembl chr X:99,228,458...99,247,763
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G |
Tes |
testin LIM domain protein |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TES mRNA |
CTD |
PMID:21784091 |
|
NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:45,365,285...45,403,829
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G |
Tf |
transferrin |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of TF mRNA |
CTD |
PMID:16510358 |
|
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
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G |
Tff1 |
trefoil factor 1 |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA] |
CTD |
PMID:17317680 |
|
NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597
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G |
Tff3 |
trefoil factor 3 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TFF3 mRNA |
CTD |
PMID:22213190 |
|
NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054
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G |
Tfrc |
transferrin receptor |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TFRC mRNA |
CTD |
PMID:21785164 |
|
NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein] 2-Acetylaminofluorene results in increased expression of TGFB1 mRNA |
CTD |
PMID:15368444 PMID:15940639 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G |
Thrb |
thyroid hormone receptor beta |
increases activity |
ISO |
2-Acetylaminofluorene results in increased activity of THRB protein |
CTD |
PMID:31077750 |
|
NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916
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G |
Thy1 |
Thy-1 cell surface antigen |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of THY1 protein |
CTD |
PMID:17576600 |
|
NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:44,389,513...44,394,659
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TIMP1 mRNA |
CTD |
PMID:18678246 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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G |
Tkt |
transketolase |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TKT mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TKT mRNA |
CTD |
PMID:14656948 PMID:16158176 |
|
NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,723,762...5,748,698
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G |
Tmem134 |
transmembrane protein 134 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of TMEM134 mRNA |
CTD |
PMID:17317680 |
|
NCBI chr 1:210,848,761...210,857,735
Ensembl chr 1:201,419,264...201,431,411
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G |
Tmem184c |
transmembrane protein 184C |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TMEM184C mRNA |
CTD |
PMID:21784091 |
|
NCBI chr19:47,249,403...47,265,502
Ensembl chr19:30,345,290...30,361,269
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G |
Tmem43 |
transmembrane protein 43 |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of TMEM43 mRNA |
CTD |
PMID:21607683 |
|
NCBI chr 4:125,534,844...125,549,986
Ensembl chr 4:123,977,625...123,992,825
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TNF protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein] |
CTD |
PMID:18271918 PMID:23665045 PMID:25051504 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of TNFRSF10B mRNA |
CTD |
PMID:21607683 |
|
NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467
|
|
G |
Top2a |
DNA topoisomerase II alpha |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TOP2A mRNA |
CTD |
PMID:22584684 |
|
NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874
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G |
Tp53 |
tumor protein p53 |
increases expression decreases expression increases response to substance multiple interactions |
EXP ISO |
2-Acetylaminofluorene results in increased expression of TP53 protein 2-Acetylaminofluorene results in increased expression of TRP53 protein 2-Acetylaminofluorene results in decreased expression of TP53 protein TRP53 protein modified form results in increased susceptibility to 2-Acetylaminofluorene TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of CYP4F15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA] [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TP53 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; Vanadium promotes the reaction [2-Acetylaminofluorene results in increased expression of TP53 protein] |
CTD |
PMID:7728945 PMID:9667752 PMID:10708481 PMID:11003613 PMID:11915028 PMID:12888115 PMID:14633663 PMID:15565650 PMID:17317680 PMID:19167416 PMID:23665045 More...
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tp53inp1 |
tumor protein p53 inducible nuclear protein 1 |
multiple interactions increases expression |
EXP ISO |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of TRP53INP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TRP53INP1 mRNA 2-Acetylaminofluorene results in increased expression of TP53INP1 mRNA 2-Acetylaminofluorene results in increased expression of TRP53INP1 mRNA |
CTD |
PMID:14656948 PMID:16158176 PMID:21607683 PMID:22584684 |
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NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:24,260,568...24,267,968
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Tp73 |
tumor protein p73 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of TP73 mRNA |
CTD |
PMID:22213190 |
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NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128
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Trpm2 |
transient receptor potential cation channel, subfamily M, member 2 |
multiple interactions |
EXP |
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA |
CTD |
PMID:16158176 |
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NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,707,014...10,753,181
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Tsc22d1 |
TSC22 domain family, member 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of TSC22D1 mRNA |
CTD |
PMID:15089088 |
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NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958
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Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
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Ttr |
transthyretin |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA] |
CTD |
PMID:17317680 |
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NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008
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Tuba1c |
tubulin, alpha 1C |
multiple interactions |
ISO |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA] |
CTD |
PMID:17317680 |
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NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:130,192,016...130,199,647 Ensembl chr X:130,192,016...130,199,647
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Tubb4b |
tubulin, beta 4B class IVb |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of TUBB4B mRNA |
CTD |
PMID:21607683 PMID:22584684 |
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NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296
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Tubb5 |
tubulin, beta 5 class I |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of TUBB5 mRNA |
CTD |
PMID:22584684 |
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NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940
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Tubb6 |
tubulin, beta 6 class V |
increases expression |
ISO |
2-Acetylaminofluorene results in increased expression of TUBB6 mRNA |
CTD |
PMID:21607683 |
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NCBI chr18:63,213,287...63,222,926
Ensembl chr18:60,943,375...60,954,418
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Ube2c |
ubiquitin-conjugating enzyme E2C |
increases expression multiple interactions |
ISO EXP |
2-Acetylaminofluorene results in increased expression of UBE2C mRNA TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA] |
CTD |
PMID:17317680 PMID:22584684 |
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NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339
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Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of 2-Acetylaminofluorene analog |
CTD |
PMID:11375903 |
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NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
ISO EXP |
2-Acetylaminofluorene results in increased expression of VCAM1 mRNA 2-Acetylaminofluorene results in increased expression of VCAM1 protein |
CTD |
PMID:21607683 PMID:25051504 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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Vegfa |
vascular endothelial growth factor A |
decreases expression multiple interactions increases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of VEGFA mRNA geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of VEGFA protein] |
CTD |
PMID:22213190 PMID:25051504 PMID:26364502 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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Wee1 |
WEE1 G2 checkpoint kinase |
increases expression |
EXP |
2-Acetylaminofluorene results in increased expression of WEE1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:164,174,779...164,197,688
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Wwox |
WW domain-containing oxidoreductase |
decreases expression |
ISO |
2-Acetylaminofluorene results in decreased expression of WWOX mRNA |
CTD |
PMID:21607683 |
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NCBI chr19:59,338,402...60,269,323
Ensembl chr19:42,432,152...43,359,391
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Xdh |
xanthine dehydrogenase |
increases activity multiple interactions |
EXP |
2-Acetylaminofluorene results in increased activity of XDH protein Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein] |
CTD |
PMID:23665045 |
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NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
decreases response to substance |
ISO |
XPC protein results in decreased susceptibility to 2-Acetylaminofluorene |
CTD |
PMID:23153559 |
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NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010
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Zeb1 |
zinc finger E-box binding homeobox 1 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ZEB1 protein |
CTD |
PMID:19167416 |
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NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
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Zeb2 |
zinc finger E-box binding homeobox 2 |
decreases expression |
EXP |
2-Acetylaminofluorene results in decreased expression of ZEB2 protein |
CTD |
PMID:19167416 |
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NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:29,218,301...29,345,157
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Zmat3 |
zinc finger, matrin type 3 |
multiple interactions increases expression |
ISO EXP |
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA] 2-Acetylaminofluorene results in increased expression of ZMAT3 mRNA |
CTD |
PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 |
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NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ABCB1A mRNA |
CTD |
PMID:22484513 |
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NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ABCB1B mRNA |
CTD |
PMID:14600272 PMID:23052194 |
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NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
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Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ABCC3 mRNA |
CTD |
PMID:23052194 |
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NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
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Aco1 |
aconitase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ACO1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
2-nitrofluorene binds to and results in increased activity of AHR protein |
CTD |
PMID:28186253 |
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NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Aif1 |
allograft inflammatory factor 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of AIF1 mRNA |
CTD |
PMID:14600272 |
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NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
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Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of AKR7A3 mRNA |
CTD |
PMID:14600272 PMID:22484513 PMID:23052194 |
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NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:14600272 PMID:22484513 PMID:23052194 |
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NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
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Anxa2 |
annexin A2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ANXA2 mRNA |
CTD |
PMID:14600272 |
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NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658
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Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of APEX1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785
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Arpc1b |
actin related protein 2/3 complex, subunit 1B |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ARPC1B mRNA |
CTD |
PMID:14600272 |
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NCBI chr12:14,595,939...14,609,501
Ensembl chr12:9,480,831...9,495,747
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Atf3 |
activating transcription factor 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ATF3 mRNA |
CTD |
PMID:15890375 |
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NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
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Atp5mc1 |
ATP synthase membrane subunit c locus 1 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of ATP5MC1 mRNA |
CTD |
PMID:14600272 |
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NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,023,925...81,027,124 Ensembl chr10:81,023,925...81,027,124
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Atp6v1d |
ATPase H+ transporting V1 subunit D |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ATP6V1D mRNA |
CTD |
PMID:14600272 PMID:22484513 PMID:23052194 |
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NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:97,656,576...97,672,303
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
2-nitrofluorene results in increased expression of BAX mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 |
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bhmt |
betaine-homocysteine S-methyltransferase |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of BHMT mRNA |
CTD |
PMID:14600272 |
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NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:24,859,873...24,879,742
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Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of BTG2 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:23052194 |
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NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
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Ccdc86 |
coiled-coil domain containing 86 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CCDC86 mRNA |
CTD |
PMID:22484513 |
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NCBI chr 1:217,015,059...217,021,439
Ensembl chr 1:207,590,168...207,596,544
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Ccnb1 |
cyclin B1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CCNB1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1 |
cyclin D1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CCND1 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Ccng1 |
cyclin G1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CCNG1 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 |
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NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641
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Cct3 |
chaperonin containing TCP1 subunit 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CCT3 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:176,063,529...176,088,180
Ensembl chr 2:173,765,698...173,790,757
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Cd1d1 |
CD1d1 molecule |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of CD1D1 mRNA |
CTD |
PMID:22484513 |
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NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:172,423,582...172,427,089
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Cd74 |
CD74 molecule |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CD74 mRNA |
CTD |
PMID:14600272 |
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NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003
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Cdc20 |
cell division cycle 20 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of CDC20 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CDK1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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Cdk16 |
cyclin-dependent kinase 16 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CDK16 mRNA |
CTD |
PMID:15890375 |
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NCBI chr X:4,046,330...4,057,825
Ensembl chr X:1,492,814...1,504,148
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Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CDK4 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CDKN1A mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Ces2c |
carboxylesterase 2C |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CES2C mRNA |
CTD |
PMID:23052194 |
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NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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Ces2h |
carboxylesterase 2H |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CES2 mRNA |
CTD |
PMID:14600272 PMID:22484513 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cgref1 |
cell growth regulator with EF hand domain 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CGREF1 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:23052194 |
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NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:25,431,799...25,443,852
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Cgrrf1 |
cell growth regulator with ring finger domain 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CGRRF1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr15:22,560,902...22,588,815
Ensembl chr15:20,088,571...20,109,037
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Cr1l |
complement C3b/C4b receptor 1 like |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CR1L mRNA |
CTD |
PMID:15890375 PMID:22484513 |
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NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445
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Cryab |
crystallin, alpha B |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CRYAB mRNA |
CTD |
PMID:14600272 |
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NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
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Cstb |
cystatin B |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CSTB mRNA |
CTD |
PMID:15890375 |
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NCBI chr20:10,245,157...10,247,199
Ensembl chr20:10,245,462...10,247,526
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G |
Ctsd |
cathepsin D |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CTSD mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctss |
cathepsin S |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CTSS mRNA |
CTD |
PMID:14600272 |
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NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CXCL10 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
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NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
affects expression |
EXP |
2-nitrofluorene affects the expression of CXCL3 mRNA |
CTD |
PMID:22484513 |
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NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
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G |
Cyb5r3 |
cytochrome b5 reductase 3 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of CYB5R3 mRNA |
CTD |
PMID:14600272 |
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NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:114,306,685...114,324,298
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of CYP1A1 mRNA |
CTD |
PMID:23052194 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2c12 |
cytochrome P450, family 2, subfamily c, polypeptide 12 |
decreases expression increases expression |
EXP |
2-nitrofluorene results in decreased expression of CYP2C12 mRNA 2-nitrofluorene results in increased expression of CYP2C12 mRNA |
CTD |
PMID:23052194 |
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NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
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G |
Dcn |
decorin |
increases expression |
EXP |
2-nitrofluorene results in increased expression of DCN mRNA |
CTD |
PMID:14600272 |
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NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270
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G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of DDAH1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
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G |
Ddx21 |
DExD-box helicase 21 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of DDX21 mRNA |
CTD |
PMID:15890375 |
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NCBI chr20:31,077,044...31,097,238
Ensembl chr20:30,534,319...30,554,543
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G |
Dkc1 |
dyskerin pseudouridine synthase 1 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of DKC1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr X:157,751,651...157,757,796
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G |
Dmbt1 |
deleted in malignant brain tumors 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of DMBT1 mRNA |
CTD |
PMID:23052194 |
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NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:185,617,294...185,696,478
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G |
Dpyd |
dihydropyrimidine dehydrogenase |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of DPYD mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982
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G |
Dus1l |
dihydrouridine synthase 1-like |
increases expression |
EXP |
2-nitrofluorene results in increased expression of DUS1L mRNA |
CTD |
PMID:22484513 |
|
NCBI chr10:106,055,519...106,062,656
Ensembl chr10:106,055,519...106,062,781
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G |
Dusp6 |
dual specificity phosphatase 6 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of DUSP6 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
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G |
Dut |
deoxyuridine triphosphatase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of DUT mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:112,498,982...112,510,771
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G |
Eef1g |
eukaryotic translation elongation factor 1 gamma |
increases expression |
EXP |
2-nitrofluorene results in increased expression of EEF1G mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:205,860,698...205,872,382
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of EEF2 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of EIF4EBP1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of EPHX1 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 |
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NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235
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G |
Fam162a |
family with sequence similarity 162, member A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of FAM162A mRNA |
CTD |
PMID:15890375 |
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NCBI chr11:78,186,260...78,215,186
Ensembl chr11:64,680,323...64,711,239
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G |
Fcgr2a |
Fc gamma receptor 2A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of FCGR3 mRNA |
CTD |
PMID:14600272 |
|
NCBI chr13:85,813,516...85,830,269
Ensembl chr13:83,280,784...83,295,967
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G |
Fkbp4 |
FKBP prolyl isomerase 4 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of FKBP4 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:161,703,379...161,711,833
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G |
Fn1 |
fibronectin 1 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of FN1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GADD45A mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
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G |
Gas6 |
growth arrest specific 6 |
decreases expression increases expression |
EXP |
2-nitrofluorene results in decreased expression of GAS6 mRNA 2-nitrofluorene results in increased expression of GAS6 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:23052194 |
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NCBI chr16:82,747,676...82,778,090
Ensembl chr16:76,045,426...76,075,904
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GCLC mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GDF15 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:23052194 |
|
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
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G |
Gls2 |
glutaminase 2 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of GLS2 mRNA |
CTD |
PMID:14600272 |
|
NCBI chr 7:1,201,757...1,218,014
Ensembl chr 7:617,288...633,426
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G |
Gnmt |
glycine N-methyltransferase |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of GNMT mRNA |
CTD |
PMID:14600272 |
|
NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:14,254,675...14,258,434
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G |
Gpr108 |
G protein-coupled receptor 108 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of GPR108 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr 9:2,207,716...2,218,738
Ensembl chr 9:2,120,744...2,132,572
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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GRIA3 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096
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G |
Grpel1 |
GrpE-like 1, mitochondrial |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GRPEL1 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr14:78,517,049...78,522,868
Ensembl chr14:74,292,023...74,298,200
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G |
Gsr |
glutathione-disulfide reductase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GSR mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GSS mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GSTA2 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GSTA5 mRNA |
CTD |
PMID:14600272 |
|
NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of GSTP1 mRNA |
CTD |
PMID:23052194 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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G |
H2ax |
H2A.X variant histone |
increases expression |
EXP |
2-nitrofluorene results in increased expression of H2AX mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
H2az1 |
H2A.Z variant histone 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of H2AZ1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:226,355,708...226,358,485
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G |
Hdc |
histidine decarboxylase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HDC mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341
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G |
Hectd1 |
HECT domain E3 ubiquitin protein ligase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HECTD1 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr 6:74,916,803...75,003,408
Ensembl chr 6:69,181,436...69,268,053
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G |
Hmgb2 |
high mobility group box 2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HMGB2 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr16:37,721,374...37,723,950
Ensembl chr16:32,710,658...32,713,140 Ensembl chr 1:32,710,658...32,713,140
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HMOX1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Hsf1 |
heat shock transcription factor 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HSF1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HSPA9 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HSPB1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
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G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HSPE1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:56,589,789...56,593,089
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of HSPH1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr12:10,427,368...10,446,602
Ensembl chr12:5,390,922...5,410,224
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G |
Ide |
insulin degrading enzyme |
increases expression |
EXP |
2-nitrofluorene results in increased expression of IDE mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:234,995,351...235,102,440
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of IGFBP1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of IGFBP3 mRNA |
CTD |
PMID:15890375 |
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NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083
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G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
2-nitrofluorene results in increased expression of IL1B protein |
CTD |
PMID:36941454 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Irf1 |
interferon regulatory factor 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of IRF1 mRNA |
CTD |
PMID:14600272 |
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NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166
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G |
Lama5 |
laminin subunit alpha 5 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of LAMA5 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr 3:187,647,904...187,695,974
Ensembl chr 3:167,270,296...167,318,451
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G |
Lgals3 |
galectin 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of LGALS3 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of MAP2K6 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293
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G |
Mat1a |
methionine adenosyltransferase 1A |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of MAT1A mRNA |
CTD |
PMID:14600272 |
|
NCBI chr16:17,017,168...17,035,368
Ensembl chr16:16,983,022...17,001,274
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G |
Mcm6 |
minichromosome maintenance complex component 6 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of MCM6 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr13:42,379,161...42,404,352
Ensembl chr13:39,826,763...39,851,960
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G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
EXP |
2-nitrofluorene results in increased expression of MDM2 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 |
|
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of MGMT mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 |
|
NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
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G |
Mt1 |
metallothionein 1 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of MT1A mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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G |
Mt2 |
metallothionein 2 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of MT2 mRNA; 2-nitrofluorene results in decreased expression of MT2A mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
EXP |
2-nitrofluorene results in increased expression of MYC mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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G |
Naglt1 |
Na+ dependent glucose transporter 1 |
affects expression |
EXP |
2-nitrofluorene affects the expression of NAGLT1 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr20:43,411,550...43,423,873
Ensembl chr20:43,394,843...43,423,873
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G |
Nap1l1 |
nucleosome assembly protein 1-like 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of NAP1L1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:46,933,356...46,956,593
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G |
Nhej1 |
nonhomologous end-joining factor 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of NHEJ1 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr 9:83,974,995...84,071,161
Ensembl chr 9:76,526,324...76,622,444
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G |
Npm1 |
nucleophosmin 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of NPM1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645 Ensembl chr X:17,739,941...17,751,645
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of NQO1 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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|
G |
Nrg1 |
neuregulin 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of NRG1 mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194 |
|
NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884
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|
G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of NUPR1 mRNA |
CTD |
PMID:15890375 PMID:23052194 |
|
NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
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G |
Oat |
ornithine aminotransferase |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of OAT mRNA |
CTD |
PMID:14600272 PMID:22484513 |
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NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682
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Obp3 |
alpha-2u globulin PGCL4 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of OBP3 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
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Odc1 |
ornithine decarboxylase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ODC1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
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Pcna |
proliferating cell nuclear antigen |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PCNA mRNA |
CTD |
PMID:15890375 |
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NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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Pdcd4 |
programmed cell death 4 |
decreases expression |
ISO |
2-nitrofluorene results in decreased expression of PDCD4 mRNA |
CTD |
PMID:21873647 |
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NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275
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Phgdh |
phosphoglycerate dehydrogenase |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of PHGDH mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944
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Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PHLDA3 mRNA |
CTD |
PMID:22484513 PMID:23052194 |
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NCBI chr13:49,745,003...49,748,088
Ensembl chr13:47,193,086...47,196,335
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G |
Pmm1 |
phosphomannomutase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PMM1 mRNA |
CTD |
PMID:22484513 |
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NCBI chr 7:115,346,767...115,357,137
Ensembl chr 7:113,466,632...113,477,022
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G |
Psma1 |
proteasome 20S subunit alpha 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMA1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:168,440,936...168,453,472
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G |
Psma2 |
proteasome 20S subunit alpha 2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMA2 mRNA |
CTD |
PMID:15890375 |
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NCBI chr17:55,250,054...55,260,441
Ensembl chr17:50,551,924...50,564,938
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G |
Psma4 |
proteasome 20S subunit alpha 4 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMA4 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890
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G |
Psma5 |
proteasome 20S subunit alpha 5 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMA5 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731
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Psma7 |
proteasome 20S subunit alpha 7 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMA7 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 3:187,514,901...187,521,289
Ensembl chr 3:167,137,263...167,143,672
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G |
Psmb1 |
proteasome 20S subunit beta 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMB1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:56,420,618...56,463,560
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G |
Psmb3 |
proteasome 20S subunit beta 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMB3 mRNA |
CTD |
PMID:15890375 |
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NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
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G |
Psmb4 |
proteasome 20S subunit beta 4 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMB4 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746
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G |
Psmb5 |
proteasome 20S subunit beta 5 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMB5 mRNA |
CTD |
PMID:15890375 |
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NCBI chr15:32,042,784...32,047,379
Ensembl chr15:28,072,781...28,077,440
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G |
Psmb8 |
proteasome 20S subunit beta 8 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMB8 mRNA |
CTD |
PMID:14600272 |
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NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,652,159...4,655,283
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Psmb9 |
proteasome 20S subunit beta 9 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMB9 mRNA |
CTD |
PMID:14600272 |
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NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,666,046...4,672,512
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G |
Psmc1 |
proteasome 26S subunit, ATPase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMC1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
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G |
Psmc2 |
proteasome 26S subunit, ATPase 2 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMC2 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185
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G |
Psmc4 |
proteasome 26S subunit, ATPase 4 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMC4 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:83,348,592...83,357,494
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G |
Psmc5 |
proteasome 26S subunit, ATPase 5 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMC5 mRNA |
CTD |
PMID:15890375 |
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NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
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G |
Psmd1 |
proteasome 26S subunit, non-ATPase 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PSMD1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:86,709,947...86,785,211
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G |
Ptp4a1 |
protein tyrosine phosphatase 4A1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of PTP4A1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:33,214,208...33,221,964
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G |
Pttg1 |
PTTG1 regulator of sister chromatid separation, securin |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of PTTG1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr10:28,394,940...28,406,410
Ensembl chr10:27,893,689...27,904,837
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Rb1 |
RB transcriptional corepressor 1 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of RB1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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G |
Rheb |
Ras homolog, mTORC1 binding |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RHEB mRNA |
CTD |
PMID:15890375 |
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NCBI chr 4:11,012,173...11,053,860
Ensembl chr 4:10,279,370...10,320,160
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G |
Rhob |
ras homolog family member B |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RHOB mRNA |
CTD |
PMID:14600272 PMID:22484513 |
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NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
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G |
Rpl10 |
ribosomal protein L10 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL10 mRNA |
CTD |
PMID:15890375 |
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NCBI chr X:157,205,850...157,208,057
Ensembl chr X:152,054,452...152,056,761
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G |
Rpl10a |
ribosomal protein L10A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL10A mRNA |
CTD |
PMID:15890375 |
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NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,385,823...6,391,357 Ensembl chr 9:6,385,823...6,391,357
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Rpl13 |
ribosomal protein L13 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL13 mRNA |
CTD |
PMID:15890375 |
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NCBI chr19:68,062,442...68,065,065
Ensembl chr19:51,153,924...51,163,014 Ensembl chr 3:51,153,924...51,163,014
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Rpl15 |
ribosomal protein L15 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL15 mRNA |
CTD |
PMID:15890375 |
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NCBI chr15:9,934,663...9,937,946
Ensembl chr15:7,503,883...7,507,165 Ensembl chr12:7,503,883...7,507,165
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Rpl17 |
ribosomal protein L17 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL17 mRNA |
CTD |
PMID:15890375 |
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NCBI chr18:70,856,275...70,859,388
Ensembl chr18:68,581,098...68,584,253 Ensembl chr 3:68,581,098...68,584,253
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Rpl23 |
ribosomal protein L23 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL23 mRNA |
CTD |
PMID:15890375 |
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NCBI chr10:83,268,223...83,272,184
Ensembl chr10:82,771,538...82,775,870
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G |
Rpl6 |
ribosomal protein L6 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL6 mRNA |
CTD |
PMID:15890375 |
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NCBI chr12:41,008,142...41,012,756
Ensembl chr12:35,347,497...35,351,921
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Rpl7a |
ribosomal protein L7A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL7A mRNA |
CTD |
PMID:15890375 |
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NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:10,239,001...10,241,716 Ensembl chr18:10,239,001...10,241,716
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G |
Rpl8 |
ribosomal protein L8 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPL8 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 7:110,506,815...110,509,106
Ensembl chr 7:108,622,324...108,628,482 Ensembl chr 3:108,622,324...108,628,482
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Rps15a |
ribosomal protein S15a |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS15A mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:181,854,396...181,861,330
Ensembl chr 1:172,419,761...172,426,995
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G |
Rps19 |
ribosomal protein S19 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS19 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
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NCBI chr 1:89,608,408...89,614,390
Ensembl chr 1:80,480,951...80,486,508 Ensembl chr 7:80,480,951...80,486,508
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Rps24 |
ribosomal protein S24 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS24 mRNA |
CTD |
PMID:15890375 |
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NCBI chr16:95,429...101,146
Ensembl chr16:89,604...94,279
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Rps27l |
ribosomal protein S27-like |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS27L mRNA |
CTD |
PMID:15890375 |
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NCBI chr 8:76,443,658...76,448,593
Ensembl chr 8:67,562,483...67,567,418 Ensembl chr12:67,562,483...67,567,418 Ensembl chr 2:67,562,483...67,567,418
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Rps3 |
ribosomal protein S3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS3 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:153,777,472...153,783,680
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Rps4x |
ribosomal protein S4, X-linked |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS4X mRNA |
CTD |
PMID:15890375 |
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NCBI chr X:71,338,478...71,342,921
Ensembl chr X:67,298,525...67,303,019 Ensembl chr 4:67,298,525...67,303,019
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Rps7 |
ribosomal protein S7 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPS7 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 6:50,994,581...50,999,447
Ensembl chr 6:45,223,980...45,271,145 Ensembl chr 5:45,223,980...45,271,145
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Rpsa |
ribosomal protein SA |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RPSA mRNA |
CTD |
PMID:15890375 |
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NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:119,851,225...119,855,247
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Rsad2 |
radical S-adenosyl methionine domain containing 2 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of RSAD2 mRNA |
CTD |
PMID:22484513 |
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NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
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RT1-Bb |
RT1 class II, locus Bb |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RT1-BB mRNA |
CTD |
PMID:14600272 |
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NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
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RT1-Da |
RT1 class II, locus Da |
increases expression |
EXP |
2-nitrofluorene results in increased expression of RT1-DA mRNA |
CTD |
PMID:14600272 |
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NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455
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G |
Sds |
serine dehydratase |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of SDS mRNA |
CTD |
PMID:14600272 |
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NCBI chr12:41,743,796...41,751,108
Ensembl chr12:36,083,229...36,088,203
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Selenow |
selenoprotein W |
increases expression |
EXP |
2-nitrofluorene results in increased expression of SELENOW mRNA |
CTD |
PMID:15890375 |
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NCBI chr 1:85,727,631...85,732,703
Ensembl chr 1:76,598,779...76,604,724 Ensembl chr 1:76,598,779...76,604,724
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Serpina7 |
serpin family A member 7 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of SERPINA7 mRNA |
CTD |
PMID:14600272 |
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NCBI chr X:107,452,044...107,510,958
Ensembl chr X:102,663,405...102,669,040
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G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of SPTAN1 mRNA |
CTD |
PMID:14600272 |
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NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:13,241,217...13,306,046
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G |
Stat1 |
signal transducer and activator of transcription 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of STAT1 mRNA |
CTD |
PMID:14600272 |
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NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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Stmn1 |
stathmin 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of STMN1 mRNA |
CTD |
PMID:15890375 |
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NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154
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G |
Tap1 |
transporter 1, ATP binding cassette subfamily B member |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TAP1 mRNA |
CTD |
PMID:14600272 |
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NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901
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Tat |
tyrosine aminotransferase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TAT mRNA |
CTD |
PMID:15890375 |
|
NCBI chr19:54,856,604...54,867,168
Ensembl chr19:37,947,112...37,958,031
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Timm10b |
translocase of inner mitochondrial membrane 10B |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TIMM10B mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 1:169,392,355...169,395,201
Ensembl chr 1:159,980,484...159,981,642 Ensembl chr20:159,980,484...159,981,642
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Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TIMP1 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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Tmsb10 |
thymosin, beta 10 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TMSB10 mRNA |
CTD |
PMID:14600272 |
|
NCBI chr 4:106,568,080...106,569,210
Ensembl chr 4:105,009,212...105,011,028
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
decreases expression increases expression |
ISO |
2-nitrofluorene results in decreased expression of TNFAIP3 mRNA 2-nitrofluorene results in increased expression of TNFAIP3 mRNA |
CTD |
PMID:21873647 |
|
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282
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G |
Top2a |
DNA topoisomerase II alpha |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TOP2A mRNA |
CTD |
PMID:15890375 |
|
NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874
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Tpd52 |
tumor protein D52 |
decreases expression increases expression |
ISO |
2-nitrofluorene results in decreased expression of TPD52 mRNA 2-nitrofluorene results in increased expression of TPD52 mRNA |
CTD |
PMID:21873647 |
|
NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622
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Trappc10 |
trafficking protein particle complex subunit 10 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TRAPPC10 mRNA |
CTD |
PMID:22484513 |
|
NCBI chr20:10,438,404...10,498,740
Ensembl chr20:10,438,737...10,499,074
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Tsc22d1 |
TSC22 domain family, member 1 |
decreases expression |
EXP |
2-nitrofluorene results in decreased expression of TSC22D1 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958
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Tuba1c |
tubulin, alpha 1C |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TUBA1C mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:130,192,016...130,199,647 Ensembl chr X:130,192,016...130,199,647
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Tubb5 |
tubulin, beta 5 class I |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TUBB5 mRNA |
CTD |
PMID:15890375 |
|
NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940
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Tyms |
thymidylate synthetase |
increases expression |
EXP |
2-nitrofluorene results in increased expression of TYMS mRNA |
CTD |
PMID:14600272 PMID:15890375 PMID:23052194 |
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NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536
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Ugt1a7c |
UDP glucuronosyltransferase 1 family, polypeptide A7C |
increases expression |
EXP |
2-nitrofluorene results in increased expression of UGT1A7 mRNA |
CTD |
PMID:14600272 |
|
NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of UGT2B17 mRNA |
CTD |
PMID:23052194 |
|
NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986
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Vegfa |
vascular endothelial growth factor A |
increases expression |
EXP |
2-nitrofluorene results in increased expression of VEGFA mRNA |
CTD |
PMID:15890375 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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Vim |
vimentin |
increases expression |
EXP |
2-nitrofluorene results in increased expression of VIM mRNA |
CTD |
PMID:14600272 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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Xdh |
xanthine dehydrogenase |
decreases expression increases reduction |
EXP ISO |
2-nitrofluorene results in decreased expression of XDH mRNA XDH protein results in increased reduction of 2-nitrofluorene |
CTD |
PMID:15890375 PMID:15932950 |
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NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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G |
Zmat3 |
zinc finger, matrin type 3 |
increases expression |
EXP |
2-nitrofluorene results in increased expression of ZMAT3 mRNA |
CTD |
PMID:14600272 PMID:15890375 |
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NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of ABCB1B mRNA |
CTD |
PMID:17070881 |
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NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
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G |
Acmsd |
aminocarboxymuconate semialdehyde decarboxylase |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of ACMSD mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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G |
Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of ACSL3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627
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G |
Aen |
apoptosis enhancing nuclease |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of AEN mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:132,815,142...132,824,523
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G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of AKR7A3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
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G |
Apoa2 |
apolipoprotein A2 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of APOA2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:86,176,767...86,178,819
Ensembl chr13:83,644,470...83,646,355
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G |
Apoa4 |
apolipoprotein A4 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of APOA4 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469
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G |
Apoc3 |
apolipoprotein C3 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of APOC3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583
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G |
Atp6v1d |
ATPase H+ transporting V1 subunit D |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of ATP6V1D mRNA |
CTD |
PMID:17070881 |
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NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:97,656,576...97,672,303
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of BAX mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Btg2 |
BTG anti-proliferation factor 2 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of BTG2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
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G |
C7 |
complement C7 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of C7 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535
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G |
Cblc |
Cbl proto-oncogene C |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of CBLC mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:79,439,977...79,456,755
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G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of CCNG1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641
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G |
Cd276 |
Cd276 molecule |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of CD276 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of CDKN1A mRNA |
CTD |
PMID:17070881 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Cpq |
carboxypeptidase Q |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of CPQ mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:64,264,081...64,724,546
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G |
Cryab |
crystallin, alpha B |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of CRYAB mRNA |
CTD |
PMID:17070881 |
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NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
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G |
Cyp2c13 |
cytochrome P450, family 2, subfamily c, polypeptide 13 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of CYP2C13 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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G |
Cyp4f5 |
cytochrome P450, family 4, subfamily f, polypeptide 5 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of CYP4F5 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
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G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of DDAH1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
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G |
Epcam |
epithelial cell adhesion molecule |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of EPCAM mRNA |
CTD |
PMID:17070881 |
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NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of EPHX1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235
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G |
Fas |
Fas cell surface death receptor |
increases expression decreases expression |
EXP |
4-acetylaminofluorene results in increased expression of FAS mRNA 4-acetylaminofluorene results in decreased expression of FAS mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G |
Fhit |
fragile histidine triad diadenosine triphosphatase |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of FHIT mRNA |
CTD |
PMID:17070881 |
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NCBI chr15:16,365,401...17,872,901
Ensembl chr15:13,934,995...15,442,340
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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of GRIA3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of GSTM1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
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G |
Hsd17b6 |
hydroxysteroid (17-beta) dehydrogenase 6 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of HSD17B6 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 7:831,407...850,950
Ensembl chr 7:422,480...442,425
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of IL2RA mRNA |
CTD |
PMID:17070881 |
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NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of MGMT mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of NUPR1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of PHLDA3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr13:49,745,003...49,748,088
Ensembl chr13:47,193,086...47,196,335
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G |
Por |
cytochrome p450 oxidoreductase |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of POR mRNA |
CTD |
PMID:15089088 |
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NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
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G |
Rhobtb2 |
Rho-related BTB domain containing 2 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of RHOBTB2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr15:51,278,024...51,298,209
Ensembl chr15:44,870,376...44,888,651
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G |
Serpina7 |
serpin family A member 7 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of SERPINA7 mRNA |
CTD |
PMID:17070881 |
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NCBI chr X:107,452,044...107,510,958
Ensembl chr X:102,663,405...102,669,040
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G |
Slc16a10 |
solute carrier family 16 member 10 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of SLC16A10 mRNA |
CTD |
PMID:17070881 |
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NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
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G |
Spink1 |
serine peptidase inhibitor, Kazal type 1 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of SPINK1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr18:36,121,626...36,133,596
Ensembl chr18:35,824,550...35,882,642
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G |
Sugct |
succinylCoA:glutarate-CoA transferase |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of SUGCT mRNA |
CTD |
PMID:17070881 |
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NCBI chr17:52,072,012...52,929,852
Ensembl chr17:47,376,521...48,234,376
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G |
Sulf2 |
sulfatase 2 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of SULF2 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:154,822,085...154,904,415
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
increases expression |
EXP |
4-acetylaminofluorene results in increased expression of SULT2A1 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134
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G |
Tsc22d1 |
TSC22 domain family, member 1 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of TSC22D1 mRNA |
CTD |
PMID:15089088 |
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NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958
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G |
Zmat3 |
zinc finger, matrin type 3 |
decreases expression |
EXP |
4-acetylaminofluorene results in decreased expression of ZMAT3 mRNA |
CTD |
PMID:17070881 |
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NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
9-fluorenone results in increased expression of CYP1A1 protein |
CTD |
PMID:10445401 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
9-fluorenone results in increased expression of CYP2B1 protein |
CTD |
PMID:10445401 |
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NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
9-fluorenone results in increased expression of CYP3A2 protein |
CTD |
PMID:10445401 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
affects binding |
ISO |
ledipasvir binds to ABCG2 protein |
CTD |
PMID:33954893 |
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NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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G |
Klrc1 |
killer cell lectin like receptor C1 |
decreases expression |
ISO |
ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells |
RGD |
PMID:31218578 |
RGD:40400920 |
NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:163,147,189...163,152,425
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G |
Ncr1 |
natural cytotoxicity triggering receptor 1 |
affects expression |
ISO |
ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells |
RGD |
PMID:31218578 |
RGD:40400920 |
NCBI chr 1:78,657,409...78,665,255
Ensembl chr 1:69,616,601...69,660,558
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G |
Fshb |
follicle stimulating hormone subunit beta |
decreases secretion |
EXP |
Lumefantrine results in decreased secretion of FSHB protein |
CTD |
PMID:26811345 |
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NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
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G |
Prl |
prolactin |
increases secretion |
EXP |
Lumefantrine results in increased secretion of PRL protein |
CTD |
PMID:26811345 |
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NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
[Acetoxyacetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TP53 protein |
CTD |
PMID:10741303 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression |
EXP |
Hydroxyacetylaminofluorene results in increased expression of ABCB1B mRNA; Hydroxyacetylaminofluorene results in increased expression of ABCB1B protein |
CTD |
PMID:22084566 |
|
NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
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G |
Nat1 |
N-acetyltransferase 1 |
decreases activity |
ISO |
Hydroxyacetylaminofluorene results in decreased activity of NAT1 protein |
CTD |
PMID:19842618 |
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NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
decreases activity |
ISO |
Hydroxyacetylaminofluorene results in decreased activity of NAT2 protein |
CTD |
PMID:19842618 |
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NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
increases sulfation |
ISO |
SULT2A1 protein results in increased sulfation of Hydroxyacetylaminofluorene |
CTD |
PMID:10752640 |
|
NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134
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G |
Tp53 |
tumor protein p53 |
increases expression |
EXP |
Hydroxyacetylaminofluorene results in increased expression of TP53 protein |
CTD |
PMID:9163691 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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