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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3alpha-hydroxy-5beta-androstan-17-one
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Accession:CHEBI:28195 term browser browse the term
Definition:An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.
Synonyms:related_synonym: (3alpha,5beta)-3-hydroxyandrostan-17-one;   3alpha-Hydroxyetiocholan-17-one;   3alpha-etiocholanolone;   5-isoandrosterone;   5beta-androstan-3alpha-ol-17-one;   5beta-androsterone;   AETIOCHOLANOLONE;   Etiocholan-3alpha-ol-17-one;   Etiocholanolone;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18+,19+/m1/s1;   InChIKey=QGXBDMJGAMFCBF-BNSUEQOYSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CCC(=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
 alt_id: CHEBI:11904;   CHEBI:1710;   CHEBI:20236;   CHEBI:40622
 xref: Beilstein:2217625;   CAS:53-42-9;   DrugBank:DB02854;   HMDB:HMDB0000490;   KEGG:C04373;   LIPID_MAPS_instance:LMST02020059
 xref_mesh: MESH:D005043
 xref: PDBeChem:AE2;   PMID:1146492;   PMID:301822;   PMID:663966;   Reaxys:2217625;   Wikipedia:Etiocholanolone


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3alpha-hydroxy-5beta-androstan-17-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions
increases chemical synthesis		 ISO [AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
AKR1D1 protein alternative form results in increased chemical synthesis of Etiocholanolone; AKR1D1 protein results in increased chemical synthesis of Etiocholanolone		 CTD PMID:30928400 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Etiocholanolone CTD PMID:2429951 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          carbon atom 19802
            organic molecular entity 19775
              lipid 18000
                steroid 14707
                  androstanoid 4823
                    3alpha-hydroxy-5beta-androstan-17-one 2
                      3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbonyl compound 18949
                                    ketone 17196
                                      oxo steroid 10541
                                        17-oxo steroid 267
                                          3alpha-hydroxy-5beta-androstan-17-one 2
                                            3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
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