CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: theophylline
Accession: CHEBI:28177
browse the term
Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.
Synonyms: exact_synonym: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
related_synonym: 1,3-Dimethylxanthine; 1,3-dimethyl-7H-purine-2,6-dione; Elixophyllin; Formula=C7H8N4O2; InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9); InChIKey=ZFXYFBGIUFBOJW-UHFFFAOYSA-N; Respbid; SMILES=Cn1c2nc[nH]c2c(=O)n(C)c1=O; Theo-Dur; Theolair; Theophyllin; Uniphyl; theophylline anhydrous
alt_id: CHEBI:26940; CHEBI:45950; CHEBI:9523
xref: CAS:58-55-9; DrugBank:DB00277; Drug_Central:2620; Gmelin:51226; HMDB:HMDB0001889; KEGG:C07130; KEGG:D00371; KNApSAcK:C00001510
xref_mesh: MESH:D013806
xref: MetaCyc:CPD-12479; PDBeChem:TEP; PMID:10796631; PMID:10836323; PMID:10893702; PMID:10921764; PMID:11126990; PMID:11170036; PMID:11200776; PMID:11261527; PMID:11408152; PMID:11826912; PMID:11848250; PMID:11941393; PMID:11949272; PMID:11950649; PMID:12531775; PMID:12836095; PMID:14517178; PMID:14713563; PMID:14988770; PMID:15005370; PMID:15042504; PMID:15202575; PMID:15317832; PMID:15356646; PMID:15483348; PMID:15739418; PMID:15829161; PMID:15902964; PMID:15908149; PMID:16083514; PMID:16651698; PMID:16930490; PMID:17130682; PMID:17207928; PMID:18307508; PMID:18800032; PMID:19559058; PMID:19727789; PMID:19845735; PMID:19888960; PMID:21467671; PMID:21796703; PMID:21834615; PMID:22377744; PMID:22541679; PMID:22541837; PMID:22702215; PMID:22770225; PMID:22771369; PMID:22836872; PMID:22909172; PMID:22915350; PMID:22981724; PMID:7302609; PMID:7389811; PMID:7656958; PMID:7767539; PMID:8730732; PMID:8960878; PMID:9256615; Reaxys:13463; VSDB:1801; Wikipedia:Theophylline
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Abhd11
abhydrolase domain containing 11
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ABHD11 protein
CTD
PMID:18951874
NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
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Abl2
ABL proto-oncogene 2, non-receptor tyrosine kinase
decreases expression
ISO
Theophylline results in decreased expression of ABL2 mRNA
CTD
PMID:16083514
NCBI chr13:71,223,902...71,319,770
Ensembl chr13:68,673,722...68,839,742
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Acaa1a
acetyl-CoA acyltransferase 1A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACAA1 protein
CTD
PMID:18951874
NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:119,079,775...119,088,624
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Acadm
acyl-CoA dehydrogenase medium chain
decreases expression
EXP
Theophylline results in decreased expression of ACADM mRNA
CTD
PMID:17522070
NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Theophylline results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977
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Acot7
acyl-CoA thioesterase 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACOT7 protein
CTD
PMID:18951874
NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:162,684,645...162,779,309
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Acp5
acid phosphatase 5, tartrate resistant
increases expression
EXP
Theophylline results in increased expression of ACP5 mRNA; Theophylline results in increased expression of ACP5 protein
CTD
PMID:26851681
NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
Theophylline inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD
PMID:16430859
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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Actr2
actin related protein 2
decreases expression
ISO
Theophylline results in decreased expression of ACTR2 mRNA
CTD
PMID:16083514
NCBI chr14:98,500,119...98,535,092
Ensembl chr14:94,296,443...94,340,524
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Actr3
actin related protein 3
decreases expression
ISO
Theophylline results in decreased expression of ACTR3 mRNA
CTD
PMID:16083514
NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124
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Adad1
adenosine deaminase domain containing 1
decreases expression
ISO
Theophylline results in decreased expression of ADAD1 mRNA
CTD
PMID:18951874
NCBI chr 2:119,948,809...120,005,920
Ensembl chr 2:119,948,926...120,005,913
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Adamtsl3
ADAMTS-like 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ADAMTSL3 protein
CTD
PMID:18951874
NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986
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Adora1
adenosine A1 receptor
decreases activity multiple interactions decreases expression
EXP
Theophylline results in decreased activity of ADORA1 protein Theophylline binds to and results in decreased activity of ADORA1 protein Theophylline results in decreased expression of ADORA1 mRNA
CTD
PMID:9535120 PMID:12153486 PMID:14992338 PMID:15708489
NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801
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Aff4
ALF transcription elongation factor 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of AFF4 protein
CTD
PMID:18951874
NCBI chr10:37,998,319...38,080,580
Ensembl chr10:37,498,825...37,579,751
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Agfg1
ArfGAP with FG repeats 1
increases expression
ISO
Theophylline results in increased expression of AGFG1 mRNA
CTD
PMID:18951874
NCBI chr 9:91,572,962...91,630,688
Ensembl chr 9:84,125,120...84,178,128
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Ahctf1
AT hook containing transcription factor 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of AHCTF1 protein
CTD
PMID:18951874
NCBI chr13:91,481,936...91,536,391
Ensembl chr13:91,481,936...91,536,391
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Akt1s1
AKT1 substrate 1
increases expression
ISO
Theophylline results in increased expression of AKT1S1 mRNA
CTD
PMID:18951874
NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:95,332,898...95,339,677
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Aldoc
aldolase, fructose-bisphosphate C
decreases expression
ISO
Theophylline results in decreased expression of ALDOC mRNA
CTD
PMID:16083514
NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066
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Alg9
ALG9, alpha-1,2-mannosyltransferase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ALG9 protein
CTD
PMID:18951874
NCBI chr 8:60,013,429...60,085,159
Ensembl chr 8:51,119,365...51,182,261
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Andpro
androgen regulated protein
increases expression
EXP
Theophylline results in increased expression of CST4 mRNA
CTD
PMID:16651698
NCBI chr 3:136,718,601...136,725,131
Ensembl chr 3:136,718,602...136,724,966
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Ankdd1a
ankyrin repeat and death domain containing 1A
increases expression
ISO
Theophylline results in increased expression of ANKDD1A mRNA
CTD
PMID:18951874
NCBI chr 8:74,912,707...74,938,870
Ensembl chr 8:66,017,773...66,042,651
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Ankrd13c
ankyrin repeat domain 13C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ANKRD13C protein
CTD
PMID:18951874
NCBI chr 2:249,679,752...249,729,272
Ensembl chr 2:247,022,286...247,070,433 Ensembl chr 4:247,022,286...247,070,433
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Ankrd44
ankyrin repeat domain 44
increases expression
ISO
Theophylline results in increased expression of ANKRD44 mRNA
CTD
PMID:18951874
NCBI chr 9:56,126,746...56,427,661
Ensembl chr 9:56,126,747...56,427,508
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Aoc1
amine oxidase, copper containing 1
increases activity decreases expression
EXP ISO
Theophylline results in increased activity of AOC1 protein Theophylline results in decreased expression of AOC1 mRNA
CTD
PMID:2860926 PMID:18951874
NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:77,812,260...77,831,840
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
decreases expression
EXP
Theophylline results in decreased expression of APEX1 mRNA
CTD
PMID:17522070
NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785
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Arf1
ARF GTPase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARF1 protein
CTD
PMID:18951874
NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
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Arhgap15
Rho GTPase activating protein 15
increases expression
ISO
Theophylline results in increased expression of ARHGAP15 mRNA
CTD
PMID:18951874
NCBI chr 3:48,382,945...49,002,213
Ensembl chr 3:27,989,633...28,600,265
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Arid2
AT-rich interaction domain 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARID2 protein
CTD
PMID:18951874
NCBI chr 7:129,326,371...129,443,813
Ensembl chr 7:127,447,278...127,563,512
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Armc8
armadillo repeat containing 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARMC8 protein
CTD
PMID:18951874
NCBI chr 8:108,916,274...109,010,877
Ensembl chr 8:100,036,946...100,131,520
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARNT protein
CTD
PMID:18951874
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
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Arsb
arylsulfatase B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ARSB protein
CTD
PMID:18951874
NCBI chr 2:26,736,395...26,895,682
Ensembl chr 2:25,002,346...25,162,671
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Asap1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
increases expression
ISO
Theophylline results in increased expression of ASAP1 mRNA
CTD
PMID:18951874
NCBI chr 7:97,675,354...97,982,523
Ensembl chr 7:95,787,818...96,092,754
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Asl
argininosuccinate lyase
decreases expression
EXP
Theophylline results in decreased expression of ASL mRNA
CTD
PMID:17522070
NCBI chr12:32,295,779...32,313,257
Ensembl chr12:26,659,565...26,679,662
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Atg3
autophagy related 3
increases expression
ISO
Theophylline results in increased expression of ATG3 mRNA
CTD
PMID:18951874
NCBI chr11:69,130,948...69,159,280
Ensembl chr11:55,624,917...55,653,224
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Atpaf2
ATP synthase mitochondrial F1 complex assembly factor 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ATPAF2 protein
CTD
PMID:18951874
NCBI chr10:45,705,157...45,721,282
Ensembl chr10:45,197,441...45,221,026
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Atrx
ATRX, chromatin remodeler
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ATRX protein
CTD
PMID:18951874
NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330
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Aurkb
aurora kinase B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AURKB protein
CTD
PMID:18951874
NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837
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Azi2
5-azacytidine induced 2
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AZI2 protein Theophylline results in decreased expression of AZI2 mRNA
CTD
PMID:18951874
NCBI chr 8:126,651,268...126,674,795
Ensembl chr 8:117,773,279...117,797,847
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B3galnt2
beta-1,3-N-acetylgalactosaminyltransferase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of B3GALNT2 protein
CTD
PMID:18951874
NCBI chr17:56,030,409...56,072,952
Ensembl chr17:51,334,921...51,377,469
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B4galt7
beta-1,4-galactosyltransferase 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of B4GALT7 protein
CTD
PMID:18951874
NCBI chr17:9,023,667...9,032,742
Ensembl chr17:9,018,935...9,027,573
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Babam2
BRISC and BRCA1 A complex member 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BABAM2 protein
CTD
PMID:18951874
NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
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Bag5
BAG cochaperone 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of BAG5 protein
CTD
PMID:18951874
NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:130,768,141...130,772,970
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[Theophylline co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein] Theophylline results in decreased expression of BCL2 mRNA; Theophylline results in decreased expression of BCL2 protein
CTD
PMID:8822937 PMID:9312165 PMID:10877050 PMID:10891529 PMID:15313391 PMID:15645133 More...
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl7c
BAF chromatin remodeling complex subunit BCL7C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BCL7C protein
CTD
PMID:18951874
NCBI chr 1:182,277,163...182,324,274
Ensembl chr 1:182,260,164...182,324,163
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Bcr
BCR activator of RhoGEF and GTPase
increases expression
ISO
Theophylline results in increased expression of BCR mRNA
CTD
PMID:16083514
NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,471,668...13,597,016
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Blnk
B-cell linker
increases expression
ISO
Theophylline results in increased expression of BLNK mRNA
CTD
PMID:16083514
NCBI chr 1:249,703,064...249,770,533
Ensembl chr 1:239,753,648...239,821,113
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Bptf
bromodomain PHD finger transcription factor
decreases expression
ISO
Theophylline results in decreased expression of BPTF mRNA
CTD
PMID:18951874
NCBI chr10:92,480,007...92,582,485
Ensembl chr10:91,982,758...92,082,769
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Braf
B-Raf proto-oncogene, serine/threonine kinase
multiple interactions
EXP
[Theophylline results in increased abundance of Cyclic AMP] which results in increased activity of BRAF protein
CTD
PMID:21693435
NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
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Btbd10
BTB domain containing 10
increases expression
ISO
Theophylline results in increased expression of BTBD10 mRNA
CTD
PMID:16083514
NCBI chr 1:176,865,817...176,923,663
Ensembl chr 1:167,431,329...167,489,916
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Btg3
BTG anti-proliferation factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BTG3 protein
CTD
PMID:18951874
NCBI chr11:30,517,068...30,532,981
Ensembl chr11:17,030,160...17,046,170
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C2cd5
C2 calcium-dependent domain containing 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of C2CD5 protein
CTD
PMID:18951874
NCBI chr 4:177,700,515...177,790,576
Ensembl chr 4:175,969,545...176,055,558
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C4h3orf20
similar to human chromosome 3 open reading frame 20
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C3ORF20 protein
CTD
PMID:18951874
NCBI chr 4:124,422,033...124,470,657
Ensembl chr 4:124,432,193...124,469,254
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C5
complement C5
multiple interactions
ISO
Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]
CTD
PMID:10947063
NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994
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Calu
calumenin
increases expression
EXP
Theophylline results in increased expression of CALU mRNA
CTD
PMID:17522070
NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:57,948,997...57,976,593
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
ISO
Theophylline results in decreased expression of CAMK2D mRNA
CTD
PMID:18951874
NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178
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Cand1
cullin-associated and neddylation-dissociated 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CAND1 protein
CTD
PMID:18951874
NCBI chr 7:56,566,765...56,604,653
Ensembl chr 7:54,680,900...54,718,993
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Caprin1
cell cycle associated protein 1
increases expression
ISO
Theophylline results in increased expression of CAPRIN1 mRNA
CTD
PMID:18951874
NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:90,153,620...90,230,502
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Capza1
capping actin protein of muscle Z-line subunit alpha 1
decreases expression
ISO
Theophylline results in decreased expression of CAPZA1 mRNA
CTD
PMID:16083514
NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480
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Casp2
caspase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CASP2 protein
CTD
PMID:18951874
NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases activity
ISO
Theophylline results in increased activity of CASP3 protein
CTD
PMID:14634331
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Theophylline inhibits the reaction [Phenylisopropyladenosine results in increased expression of CAT protein]
CTD
PMID:15792369
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Cav1
caveolin 1
increases expression
ISO
Theophylline results in increased expression of CAV1 mRNA
CTD
PMID:16083514
NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705
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Ccdc181
coiled-coil domain containing 181
decreases expression
ISO
Theophylline results in decreased expression of CCDC181 mRNA
CTD
PMID:18951874
NCBI chr13:76,624,567...76,638,224
Ensembl chr13:76,624,567...76,638,224
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Ccdc30
coiled-coil domain containing 30
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC30 protein
CTD
PMID:18951874
NCBI chr 5:132,926,767...133,019,635
Ensembl chr 5:132,926,615...133,019,659
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Ccdc82
coiled-coil domain containing 82
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC82 protein
CTD
PMID:18951874
NCBI chr 8:18,509,293...18,665,008
Ensembl chr 8:10,228,430...10,265,963
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Ccdc93
coiled-coil domain containing 93
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC93 protein
CTD
PMID:18951874
NCBI chr13:35,160,354...35,233,877
Ensembl chr13:32,607,587...32,676,023
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCL2 protein
CTD
PMID:18951874
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
multiple interactions
ISO EXP
[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein [Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein; sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein]
CTD
PMID:21693435
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Ccser2
coiled-coil serine-rich protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CCSER2 protein
CTD
PMID:18951874
NCBI chr16:12,613,103...12,725,764
Ensembl chr16:12,613,103...12,725,738
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Cd33
CD33 molecule
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CD33 protein
CTD
PMID:18951874
NCBI chr 1:103,071,985...103,086,687
Ensembl chr 1:93,930,971...93,950,149
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Cd36
CD36 molecule
decreases expression
ISO
Theophylline results in decreased expression of CD36 mRNA
CTD
PMID:16083514
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
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Cd4
Cd4 molecule
decreases expression
ISO
Theophylline results in decreased expression of CD4 protein
CTD
PMID:11408767
NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:157,668,878...157,695,191
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Cdk13
cyclin-dependent kinase 13
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CDK13 protein
CTD
PMID:18951874
NCBI chr17:51,945,975...52,040,218
Ensembl chr17:47,251,163...47,341,721
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO EXP
[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein [Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein; sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]
CTD
PMID:21693435
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
increases expression
ISO
Theophylline results in increased expression of CDKN1C mRNA
CTD
PMID:16083514
NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:198,655,407...198,658,048
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Ceacam1
CEA cell adhesion molecule 1
decreases expression
EXP
Theophylline results in decreased expression of CEACAM1 mRNA
CTD
PMID:17522070
NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992
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Cenpu
centromere protein U
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CENPU protein
CTD
PMID:18951874
NCBI chr16:52,448,446...52,471,662
Ensembl chr16:45,714,294...45,738,823
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Cep290
centrosomal protein 290
decreases expression
ISO
Theophylline results in decreased expression of CEP290 mRNA
CTD
PMID:18951874
NCBI chr 7:37,196,765...37,285,955
Ensembl chr 7:35,310,199...35,399,392
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Cep63
centrosomal protein 63
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CEP63 protein
CTD
PMID:18951874
NCBI chr 8:112,041,586...112,093,061
Ensembl chr 8:103,162,700...103,214,177
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Cept1
choline/ethanolamine phosphotransferase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CEPT1 protein
CTD
PMID:18951874
NCBI chr 2:196,682,455...196,724,430
Ensembl chr 2:193,993,447...194,035,578
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Cfap97
cilia and flagella associated protein 97
increases expression
ISO
Theophylline results in increased expression of CFAP97 mRNA
CTD
PMID:18951874
NCBI chr16:46,086,104...46,135,194
Ensembl chr16:46,086,111...46,125,933
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Cga
glycoprotein hormones, alpha polypeptide
multiple interactions increases expression increases stability
ISO
[Theophylline co-treated with Butyric Acid] results in increased expression of CGA mRNA; Theophylline inhibits the reaction [Butyric Acid results in decreased stability of CGA mRNA]; Theophylline promotes the reaction [Butyric Acid results in increased expression of CGA protein] Theophylline results in increased expression of CGA protein Theophylline results in increased stability of CGA mRNA
CTD
PMID:1693836 PMID:1693837
NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:49,487,068...49,499,191
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Clec16a
C-type lectin domain containing 16A
decreases expression
ISO
Theophylline results in decreased expression of CLEC16A mRNA
CTD
PMID:18951874
NCBI chr10:5,434,725...5,631,246
Ensembl chr10:4,928,030...5,123,578
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Clec4f
C-type lectin domain family 4, member F
decreases expression
ISO
Theophylline results in decreased expression of CLEC4F mRNA
CTD
PMID:18951874
NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
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Clpb
ClpB family mitochondrial disaggregase
multiple interactions increases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CLPB protein Theophylline results in increased expression of CLPB mRNA
CTD
PMID:18951874
NCBI chr 1:165,440,705...165,563,514
Ensembl chr 1:156,028,930...156,168,788
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Clu
clusterin
increases expression
EXP
Theophylline results in increased expression of CLU mRNA
CTD
PMID:17522070
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
Theophylline inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
CTD
PMID:16430859
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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Coq4
coenzyme Q4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of COQ4 protein
CTD
PMID:18951874
NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799
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Cox5b
cytochrome c oxidase subunit 5B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of COX5B protein
CTD
PMID:18951874
NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:38,921,967...38,925,052
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Cpm
carboxypeptidase M
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CPM protein
CTD
PMID:18951874
NCBI chr 7:55,111,599...55,172,114
Ensembl chr 7:53,225,696...53,286,220
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Cpne1
copine 1
affects binding
ISO
Theophylline binds to CPNE1 protein
CTD
PMID:18951874
NCBI chr 3:165,047,615...165,089,994
Ensembl chr 3:144,588,995...144,598,636
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Creld1
cysteine-rich with EGF-like domains 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CRELD1 protein
CTD
PMID:18951874
NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499
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Crtc3
CREB regulated transcription coactivator 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CRTC3 protein
CTD
PMID:18951874
NCBI chr 1:143,962,038...144,064,324
Ensembl chr 1:134,554,696...134,655,500
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Csf2
colony stimulating factor 2
multiple interactions decreases expression
ISO
[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] Theophylline results in decreased expression of CSF2 mRNA
CTD
PMID:10374451 PMID:10596698 PMID:12070353
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
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Csf3
colony stimulating factor 3
increases expression
ISO
Theophylline results in increased expression of CSF3 protein
CTD
PMID:7540958
NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
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Csnk1e
casein kinase 1, epsilon
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CSNK1E protein
CTD
PMID:18951874
NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:110,983,318...111,006,794
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Ctps1
CTP synthase 1
decreases expression
ISO
Theophylline results in decreased expression of CTPS1 mRNA
CTD
PMID:16083514
NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:134,125,025...134,154,180
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Ctrl
chymotrypsin-like
increases expression
ISO
Theophylline results in increased expression of CTRL mRNA
CTD
PMID:18951874
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
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Ctsb
cathepsin B
increases expression
ISO
Theophylline results in increased expression of CTSB mRNA
CTD
PMID:16083514
NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
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Ctsl
cathepsin L
decreases expression
EXP
Theophylline results in decreased expression of CTSL mRNA
CTD
PMID:17522070
NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases activity affects metabolic processing increases metabolic processing affects hydroxylation affects response to substance increases chemical synthesis
ISO EXP
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]; zafirlukast inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] Theophylline results in decreased activity of CYP1A2 protein andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; Plant Extracts affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline] CYP1A2 gene SNP affects the metabolism of Theophylline; CYP1A2 protein affects the metabolism of Theophylline CYP1A2 promoter SNP affects the hydroxylation of Theophylline CYP1A2 gene SNP affects the susceptibility to Theophylline CYP1A2 protein results in increased chemical synthesis of Theophylline
CTD
PMID:1302044 PMID:9029748 PMID:9701106 PMID:11408986 PMID:11465391 PMID:11483122 PMID:12732846 PMID:15692829 PMID:15720787 PMID:15948934 PMID:15970798 PMID:15985363 PMID:16841220 PMID:20096675 PMID:20797314 PMID:31132250 More...
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
EXP
Theophylline results in decreased expression of CYP27A1 protein
CTD
PMID:26851681
NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551
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Cyp2d3
cytochrome P450, family 2, subfamily d, polypeptide 3
decreases expression
EXP
Theophylline results in decreased expression of CYP2D3 mRNA
CTD
PMID:17522070
NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:113,908,947...113,922,084
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
affects metabolic processing affects hydroxylation increases chemical synthesis
EXP ISO
CYP2E1 protein affects the metabolism of Theophylline CYP2E1 promoter SNP affects the hydroxylation of Theophylline CYP2E1 protein results in increased chemical synthesis of Theophylline
CTD
PMID:1302044 PMID:15948934 PMID:15985363 PMID:16841220
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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Cyp2r1
cytochrome P450, family 2, subfamily r, polypeptide 1
decreases expression
EXP
Theophylline results in decreased expression of CYP2R1 protein
CTD
PMID:26851681
NCBI chr 1:178,166,984...178,232,191
Ensembl chr 1:168,751,038...168,797,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline]
CTD
PMID:11408986
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Cysltr1
cysteinyl leukotriene receptor 1
decreases expression
ISO
Theophylline results in decreased expression of CYSLTR1 mRNA
CTD
PMID:18951874
NCBI chr X:75,734,281...75,762,873
Ensembl chr X:71,663,821...71,690,121
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Dab2
DAB adaptor protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DAB2 protein
CTD
PMID:18951874
NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476
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Dact3
dishevelled-binding antagonist of beta-catenin 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DACT3 protein
CTD
PMID:18951874
NCBI chr 1:86,674,989...86,686,722
Ensembl chr 1:77,546,900...77,558,630
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Dcbld1
discoidin, CUB and LCCL domain containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DCBLD1 protein
CTD
PMID:18951874
NCBI chr20:31,618,556...31,711,697
Ensembl chr20:31,618,542...31,711,692
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Ddi2
DNA damage inducible 1 homolog 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DDI2 protein
CTD
PMID:18951874
NCBI chr 5:159,272,625...159,318,365
Ensembl chr 5:153,995,589...154,035,283
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Dhx8
DEAH-box helicase 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DHX8 protein
CTD
PMID:18951874
NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137
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Dlg1
discs large MAGUK scaffold protein 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DLG1 protein
CTD
PMID:18951874
NCBI chr11:82,416,853...82,607,797
Ensembl chr11:68,911,883...69,102,689
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Dmac2l
distal membrane arm assembly component 2 like
decreases expression
ISO
Theophylline results in decreased expression of DMAC2L mRNA
CTD
PMID:18951874
NCBI chr 6:93,941,605...93,959,932
Ensembl chr 6:88,205,700...88,223,933
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Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DNAJC15 protein
CTD
PMID:18951874
NCBI chr15:59,594,314...59,658,862
Ensembl chr15:53,184,855...53,249,675
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Dnajc4
DnaJ heat shock protein family (Hsp40) member C4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DNAJC4 protein
CTD
PMID:18951874
NCBI chr 1:213,607,397...213,611,614
Ensembl chr 1:204,178,191...204,182,387
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Dock4
dedicator of cytokinesis 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DOCK4 protein
CTD
PMID:18951874
NCBI chr 6:63,240,050...63,629,772
Ensembl chr 6:57,512,908...57,901,855
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Dolk
dolichol kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DOLK protein
CTD
PMID:18951874
NCBI chr 3:13,557,826...13,559,864
Ensembl chr 3:13,557,817...13,559,917
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Drd5
dopamine receptor D5
increases expression
ISO
Theophylline results in increased expression of DRD5 mRNA
CTD
PMID:18951874
NCBI chr14:76,700,244...76,703,344
Ensembl chr14:72,489,347...72,490,774
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Dusp19
dual specificity phosphatase 19
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DUSP19 protein
CTD
PMID:18951874
NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
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Ears2
glutamyl-tRNA synthetase 2, mitochondrial
increases expression
ISO
Theophylline results in increased expression of EARS2 mRNA
CTD
PMID:18951874
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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Edn1
endothelin 1
multiple interactions
ISO
Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]
CTD
PMID:10374451
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
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Egln3
egl-9 family hypoxia-inducible factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EGLN3 protein
CTD
PMID:18951874
NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766
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Eif1b
eukaryotic translation initiation factor 1B
decreases expression
ISO
Theophylline results in decreased expression of EIF1B mRNA
CTD
PMID:16083514
NCBI chr 8:120,203,561...120,206,176
Ensembl chr 8:120,203,451...120,206,176 Ensembl chr 5:120,203,451...120,206,176
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Eif2s3
eukaryotic translation initiation factor 2 subunit gamma
increases expression
ISO
Theophylline results in increased expression of EIF2S3 mRNA
CTD
PMID:16083514
NCBI chr X:62,910,292...62,933,936
Ensembl chr X:58,917,490...58,940,686
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Eif3a
eukaryotic translation initiation factor 3, subunit A
increases expression
ISO
Theophylline results in increased expression of EIF3A mRNA
CTD
PMID:16083514
NCBI chr 1:269,888,730...269,925,785
Ensembl chr 1:259,902,680...259,932,976
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Eif3b
eukaryotic translation initiation factor 3, subunit B
increases expression
ISO
Theophylline results in increased expression of EIF3B mRNA
CTD
PMID:18951874
NCBI chr12:19,310,308...19,334,768
Ensembl chr12:14,196,403...14,220,886
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Eif3e
eukaryotic translation initiation factor 3 subunit E
decreases expression
ISO
Theophylline results in decreased expression of EIF3E mRNA
CTD
PMID:16083514
NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
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Eif4b
eukaryotic translation initiation factor 4B
increases expression
ISO
Theophylline results in increased expression of EIF4B mRNA
CTD
PMID:16083514
NCBI chr 7:135,085,259...135,107,054
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Eif5
eukaryotic translation initiation factor 5
decreases expression
ISO
Theophylline results in decreased expression of EIF5 mRNA
CTD
PMID:16083514
NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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Elp6
elongator acetyltransferase complex subunit 6
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ELP6 protein
CTD
PMID:18951874
NCBI chr 8:119,158,380...119,173,483
Ensembl chr 8:110,279,979...110,295,067
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Emc3
ER membrane protein complex subunit 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EMC3 protein
CTD
PMID:18951874
NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:146,663,067...146,679,029
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Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ENTPD5 protein
CTD
PMID:18951874
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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Epg5
ectopic P-granules 5 autophagy tethering factor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EPG5 protein
CTD
PMID:18951874
NCBI chr18:73,679,106...73,776,694
Ensembl chr18:71,404,010...71,501,502
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Eps15
epidermal growth factor receptor pathway substrate 15
decreases expression
ISO
Theophylline results in decreased expression of EPS15 mRNA
CTD
PMID:18951874
NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:124,045,926...124,146,221
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Eps8l1
EPS8 signaling adaptor L1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EPS8L1 protein
CTD
PMID:18951874
NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
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Ercc5
ERCC excision repair 5, endonuclease
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein
CTD
PMID:18951874
NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:46,309,389...46,354,472
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Erf
Ets2 repressor factor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERF protein
CTD
PMID:18951874
NCBI chr 1:89,957,760...89,966,213
Ensembl chr 1:80,829,935...80,838,388
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Ergic1
endoplasmic reticulum-golgi intermediate compartment 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERGIC1 protein
CTD
PMID:18951874
NCBI chr10:17,035,615...17,131,411
Ensembl chr10:16,531,194...16,626,957
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Erlin1
ER lipid raft associated 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERLIN1 protein
CTD
PMID:18951874
NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:242,921,152...242,956,394
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Erlin2
ER lipid raft associated 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERLIN2 protein
CTD
PMID:18951874
NCBI chr16:71,720,486...71,736,999
Ensembl chr16:65,018,532...65,033,671
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Evi2b
ecotropic viral integration site 2B
decreases expression
ISO
Theophylline results in decreased expression of EVI2B mRNA
CTD
PMID:16083514
NCBI chr10:64,970,659...64,972,277
Ensembl chr10:64,471,505...64,481,560
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Exosc3
exosome component 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EXOSC3 protein
CTD
PMID:18951874
NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
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Exosc4
exosome component 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EXOSC4 protein
CTD
PMID:18951874
NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:108,047,831...108,050,573
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Eya3
EYA transcriptional coactivator and phosphatase 3
increases expression
ISO
Theophylline results in increased expression of EYA3 mRNA
CTD
PMID:18951874
NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518
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Fabp1
fatty acid binding protein 1
increases expression
EXP
Theophylline results in increased expression of FABP1 mRNA
CTD
PMID:17522070
NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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Fads3
fatty acid desaturase 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FADS3 protein
CTD
PMID:18951874
NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
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Fam171b
family with sequence similarity 171, member B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FAM171B protein
CTD
PMID:18951874
NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127
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Fam222b
family with sequence similarity 222, member B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FAM222B protein
CTD
PMID:18951874
NCBI chr10:62,986,571...63,052,350
Ensembl chr10:62,986,571...63,052,350
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Fbxo8
F-box protein 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FBXO8 protein
CTD
PMID:18951874
NCBI chr16:38,676,011...38,721,849
Ensembl chr16:33,665,306...33,711,272
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Fchsd2
FCH and double SH3 domains 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FCHSD2 protein
CTD
PMID:18951874
NCBI chr 1:164,775,916...165,097,391
Ensembl chr 1:155,444,460...155,685,539
G
Fdxr
ferredoxin reductase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FDXR protein
CTD
PMID:18951874
NCBI chr10:101,006,845...101,015,582
Ensembl chr10:100,507,865...100,516,658
G
Fga
fibrinogen alpha chain
increases expression
EXP
Theophylline results in increased expression of FGA mRNA
CTD
PMID:17522070
NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528
G
Fgb
fibrinogen beta chain
increases expression
EXP
Theophylline results in increased expression of FGB mRNA
CTD
PMID:17522070
NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979
G
Fgf23
fibroblast growth factor 23
increases expression multiple interactions
EXP
Theophylline results in increased expression of FGF23 protein Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]
CTD
PMID:26851681
NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:159,914,272...159,923,821
G
Fhl3
four and a half LIM domains 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FHL3 protein
CTD
PMID:18951874
NCBI chr 5:136,953,947...136,961,317
Ensembl chr 5:136,950,411...136,961,317
G
Fibp
FGF1 intracellular binding protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FIBP protein
CTD
PMID:18951874
NCBI chr 1:212,197,216...212,201,732
Ensembl chr 1:202,768,078...202,772,399
G
Fip1l1
factor interacting with PAPOLA and CPSF1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FIP1L1 protein
CTD
PMID:18951874
NCBI chr14:33,615,210...33,675,742
Ensembl chr14:33,617,720...33,675,708
G
Fitm2
fat storage-inducing transmembrane protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FITM2 protein
CTD
PMID:18951874
NCBI chr 3:172,560,781...172,567,291
Ensembl chr 3:152,141,346...152,147,858
G
Flot2
flotillin 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FLOT2 protein
CTD
PMID:18951874
NCBI chr10:63,424,084...63,445,811
Ensembl chr10:62,920,665...62,947,756
G
Fnbp4
formin binding protein 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FNBP4 protein
CTD
PMID:18951874
NCBI chr 3:76,733,012...76,763,077
Ensembl chr 3:76,733,027...76,763,079
G
Fntb
farnesyltransferase, CAAX box, subunit beta
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FNTB protein
CTD
PMID:18951874
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586
G
Folr1
folate receptor alpha
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FOLR1 protein
CTD
PMID:18951874
NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:156,219,460...156,230,667
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Theophylline inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]
CTD
PMID:8577368 PMID:10199625
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Foxf2
forkhead box F2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FOXF2 protein
CTD
PMID:18951874
NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,836,777...32,842,176
G
Foxk2
forkhead box K2
increases expression
ISO
Theophylline results in increased expression of FOXK2 mRNA
CTD
PMID:16083514
NCBI chr10:107,040,933...107,090,860
Ensembl chr10:106,542,566...106,592,563
G
Fsd1l
fibronectin type III and SPRY domain containing 1-like
increases expression
ISO
Theophylline results in increased expression of FSD1L mRNA
CTD
PMID:18951874
NCBI chr 5:73,052,565...73,130,292
Ensembl chr 5:68,258,932...68,334,928
G
Gabarapl1
GABA type A receptor associated protein like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABARAPL1 protein
CTD
PMID:18951874
NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:162,980,249...162,989,450
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:11234751
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:11234751
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:11234751
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
G
Gabrr2
gamma-aminobutyric acid type A receptor subunit rho 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABRR2 protein
CTD
PMID:18951874
NCBI chr 5:52,242,564...52,286,255
Ensembl chr 5:47,452,150...47,489,809
G
Gck
glucokinase
increases expression
EXP
Theophylline results in increased expression of GCK mRNA
CTD
PMID:17522070
NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995
G
Gdf15
growth differentiation factor 15
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein
CTD
PMID:18951874
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
G
Gfpt1
glutamine fructose-6-phosphate transaminase 1
increases expression
ISO
Theophylline results in increased expression of GFPT1 mRNA
CTD
PMID:16083514
NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:119,496,714...119,546,471
G
Ggps1
geranylgeranyl diphosphate synthase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GGPS1 protein
CTD
PMID:18951874
NCBI chr17:55,958,750...55,982,762
Ensembl chr17:51,263,263...51,276,220
G
Gkap1
G kinase anchoring protein 1
increases expression
ISO
Theophylline results in increased expression of GKAP1 mRNA
CTD
PMID:18951874
NCBI chr17:6,389,377...6,429,091
Ensembl chr17:6,383,963...6,423,679
G
Glrx3
glutaredoxin 3
increases expression
ISO
Theophylline results in increased expression of GLRX3 mRNA
CTD
PMID:18951874
NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010
G
Gls
glutaminase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GLS protein
CTD
PMID:18951874
NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900
G
Gnai1
G protein subunit alpha i1
decreases expression increases expression
EXP
Theophylline results in decreased expression of GNAI1 protein Theophylline results in increased expression of GNAI1 mRNA
CTD
PMID:15708489
NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
decreases expression
EXP
Theophylline results in decreased expression of GNAI2 protein
CTD
PMID:15708489
NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979
G
Gnaq
G protein subunit alpha q
decreases expression
EXP
Theophylline results in decreased expression of GNAQ protein
CTD
PMID:15998294
NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672
G
Gnas
GNAS complex locus
decreases expression
EXP
Theophylline results in decreased expression of GNAS protein
CTD
PMID:15708489
NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnb1
G protein subunit beta 1
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GNB1 protein Theophylline results in decreased expression of GNB1 mRNA
CTD
PMID:16083514 PMID:18951874
NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:166,075,629...166,142,124
G
Gpatch8
G patch domain containing 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GPATCH8 protein
CTD
PMID:18951874
NCBI chr10:87,432,020...87,512,594
Ensembl chr10:87,433,266...87,512,419
G
Gpm6a
glycoprotein m6a
increases expression
ISO
Theophylline results in increased expression of GPM6A mRNA
CTD
PMID:16083514
NCBI chr16:43,374,385...43,706,461
Ensembl chr16:36,641,284...36,973,475
G
Gpr137c
G protein-coupled receptor 137C
increases expression
ISO
Theophylline results in increased expression of GPR137C mRNA
CTD
PMID:18951874
NCBI chr15:20,905,923...20,972,318
Ensembl chr15:18,426,223...18,490,807
G
Gpx1
glutathione peroxidase 1
decreases expression
EXP
Theophylline results in decreased expression of GPX1 mRNA
CTD
PMID:17522070
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
G
Grk3
G protein-coupled receptor kinase 3
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRK3 protein Theophylline results in decreased expression of GRK3 mRNA
CTD
PMID:18951874
NCBI chr12:49,285,228...49,395,803
Ensembl chr12:43,624,897...43,731,262
G
Grm1
glutamate metabotropic receptor 1
decreases expression
EXP
Theophylline results in decreased expression of GRM1 protein
CTD
PMID:15998294
NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170
G
Grm6
glutamate metabotropic receptor 6
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRM6 protein
CTD
PMID:18951874
NCBI chr10:35,669,003...35,683,729
Ensembl chr10:35,167,985...35,182,717
G
Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation
ISO
Theophylline results in increased phosphorylation of GSK3B protein
CTD
PMID:32001318
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
Theophylline inhibits the reaction [Phenylisopropyladenosine results in increased expression of GSR protein]
CTD
PMID:15792369
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Gstm2
glutathione S-transferase mu 2
decreases expression
ISO
Theophylline results in decreased expression of GSTM2 mRNA
CTD
PMID:16083514
NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
G
Gstm5
glutathione S-transferase, mu 5
decreases expression
EXP
Theophylline results in decreased expression of GSTM3 mRNA
CTD
PMID:17522070
NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553
G
H2ac18
H2A clustered histone 18
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of H2AC18 protein
CTD
PMID:18951874
NCBI chr 2:186,497,271...186,497,865
G
Hadh
hydroxyacyl-CoA dehydrogenase
decreases expression
ISO
Theophylline results in decreased expression of HADH mRNA
CTD
PMID:16083514
NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:219,787,927...219,830,353
G
Hdac1
histone deacetylase 1
increases activity increases expression
ISO
Theophylline results in increased activity of HDAC1 protein Theophylline results in increased expression of HDAC1 protein
CTD
PMID:12070353 PMID:15337792
NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111
G
Hdac2
histone deacetylase 2
increases expression
ISO
Theophylline results in increased expression of HDAC2 protein
CTD
PMID:15337792
NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609
G
Hdac3
histone deacetylase 3
increases activity
ISO
Theophylline results in increased activity of HDAC3 protein
CTD
PMID:12070353
NCBI chr18:30,021,847...30,041,061
Ensembl chr18:29,770,636...29,793,856
G
Hdc
histidine decarboxylase
affects response to substance
ISO
HDC protein affects the susceptibility to Theophylline
CTD
PMID:12893847
NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341
G
Helq
helicase, POLQ-like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HELQ protein
CTD
PMID:18951874
NCBI chr14:9,122,978...9,167,310
Ensembl chr14:8,818,592...8,862,960
G
Hemk1
HemK methyltransferase family member 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HEMK1 protein
CTD
PMID:18951874
NCBI chr 8:107,999,658...108,010,732
Ensembl chr 8:107,999,644...108,010,256
G
Hibadh
3-hydroxyisobutyrate dehydrogenase
decreases expression
EXP
Theophylline results in decreased expression of HIBADH mRNA
CTD
PMID:17522070
NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:81,649,175...81,780,617
G
Hint1
histidine triad nucleotide binding protein 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of HINT1 protein
CTD
PMID:18951874
NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:92,100,973...92,101,568
G
Hist1h2ail1
histone cluster 1 H2a family member I like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of H3C6 protein
CTD
PMID:18951874
NCBI chr17:41,996,216...41,997,128
Ensembl chr17:41,568,471...41,569,109
G
Hm13
histocompatibility minor 13
affects binding
ISO
Theophylline binds to HM13 protein
CTD
PMID:18951874
NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:141,145,782...141,184,703
G
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HNRNPH3 protein
CTD
PMID:18951874
NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750
G
Hps4
HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
decreases expression
ISO
Theophylline results in decreased expression of HPS4 mRNA
CTD
PMID:18951874
NCBI chr12:44,264,037...44,294,791
Ensembl chr12:44,264,037...44,294,632
G
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HSD17B14 protein
CTD
PMID:18951874
NCBI chr 1:105,165,695...105,176,045
Ensembl chr 1:96,029,284...96,039,883
G
Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
ISO
Theophylline results in increased expression of HSPA2 mRNA
CTD
PMID:16083514
NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287
G
Htra2
HtrA serine peptidase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein
CTD
PMID:18951874
NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:115,556,916...115,560,095
G
Hus1
HUS1 checkpoint clamp component
decreases expression
ISO
Theophylline results in decreased expression of HUS1 mRNA
CTD
PMID:18951874
NCBI chr14:87,902,458...87,917,221
Ensembl chr14:83,688,708...83,703,442
G
Icam4
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICAM4 protein
CTD
PMID:18951874
NCBI chr 8:19,566,075...19,567,171
Ensembl chr 8:19,566,075...19,567,171
G
Ice2
interactor of little elongation complex ELL subunit 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICE2 protein
CTD
PMID:18951874
NCBI chr 8:70,043,419...70,085,217
Ensembl chr 8:70,043,424...70,084,995
G
Idua
alpha-L-iduronidase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IDUA protein
CTD
PMID:18951874
NCBI chr14:1,175,994...1,203,913
Ensembl chr14:1,032,171...1,046,522
G
Ier2
immediate early response 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IER2 protein
CTD
PMID:18951874
NCBI chr19:40,399,373...40,400,897
Ensembl chr19:23,494,184...23,499,211
G
Ifna1
interferon, alpha 1
decreases metabolic processing
ISO
IFNA1 protein results in decreased metabolism of Theophylline
CTD
PMID:9114909
NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925
G
Ifng
interferon gamma
decreases expression
ISO
Theophylline results in decreased expression of IFNG mRNA
CTD
PMID:10596698
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Ift122
intraflagellar transport 122
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IFT122 protein
CTD
PMID:18951874
NCBI chr 4:148,905,031...148,975,458
Ensembl chr 4:148,905,046...148,975,458
G
Ift57
intraflagellar transport 57
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT57 protein
CTD
PMID:18951874
NCBI chr11:51,051,520...51,124,909
Ensembl chr11:51,059,611...51,124,812
G
Ift88
intraflagellar transport 88
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT88 protein
CTD
PMID:18951874
NCBI chr15:35,685,678...35,786,875
Ensembl chr15:31,573,376...31,672,147
G
Igfbp5
insulin-like growth factor binding protein 5
decreases expression
ISO
Theophylline results in decreased expression of IGFBP5 mRNA
CTD
PMID:16083514
NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:74,448,382...74,465,156
G
Ihh
Indian hedgehog signaling molecule
increases expression
ISO
Theophylline results in increased expression of IHH mRNA
CTD
PMID:16083514
NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532
G
Ikbip
IKBKB interacting protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IKBIP protein
CTD
PMID:18951874
NCBI chr 7:27,467,097...27,485,776
Ensembl chr 7:25,579,832...25,605,162
G
Il10
interleukin 10
decreases secretion
ISO
Theophylline results in decreased secretion of IL10 protein
CTD
PMID:11694023
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
G
Il12a
interleukin 12A
multiple interactions
ISO
Theophylline results in decreased expression of [IL12A protein binds to IL12B protein]
CTD
PMID:15569413
NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
G
Il12b
interleukin 12B
multiple interactions decreases expression
ISO
Theophylline results in decreased expression of [IL12A protein binds to IL12B protein] Theophylline results in decreased expression of IL12B protein
CTD
PMID:15569413
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
G
Il13
interleukin 13
decreases expression decreases secretion
ISO
Theophylline results in decreased expression of IL13 mRNA; Theophylline results in decreased expression of IL13 protein Theophylline results in decreased secretion of IL13 protein
CTD
PMID:16083514
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
G
Il18
interleukin 18
multiple interactions
ISO
Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]
CTD
PMID:18951874
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
EXP ISO
Theophylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein] [Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4C16 protein]]]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
CTD
PMID:12070353 PMID:15337792 PMID:16133968 PMID:18951874
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
increases secretion
ISO
Theophylline results in increased secretion of IL2 protein
CTD
PMID:11694023
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
G
Il2ra
interleukin 2 receptor subunit alpha
decreases expression
ISO
Theophylline results in decreased expression of IL2RA protein
CTD
PMID:1709825
NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
G
Il3
interleukin 3
decreases expression
ISO
Theophylline results in decreased expression of IL3 mRNA
CTD
PMID:10596698
NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066
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Il4
interleukin 4
multiple interactions decreases secretion decreases expression
ISO
IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein] Theophylline results in decreased secretion of IL4 protein Theophylline results in decreased expression of IL4 mRNA
CTD
PMID:8822937 PMID:10596698 PMID:11694023
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
multiple interactions increases expression
ISO
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Bucladesine co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dinoprostone co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of IL6 protein] Theophylline results in increased expression of IL6 mRNA
CTD
PMID:11770011 PMID:16083514 PMID:20388727
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
decreases expression
ISO
Theophylline results in decreased expression of IL6R mRNA
CTD
PMID:18951874
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536
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Il6st
interleukin 6 cytokine family signal transducer
increases expression
ISO
Theophylline results in increased expression of IL6ST mRNA
CTD
PMID:16083514
NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:44,066,130...44,109,936
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Ilk
integrin-linked kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ILK protein
CTD
PMID:18951874
NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140
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Inip
INTS3 and NABP interacting protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of INIP protein
CTD
PMID:18951874
NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628
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Ins1
insulin 1
multiple interactions
EXP
[Theophylline co-treated with INS1 protein] results in decreased abundance of Cyclic AMP; INS1 protein inhibits the reaction [[Theophylline co-treated with Norepinephrine] results in increased abundance of Cyclic AMP]; INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]
CTD
PMID:4306506
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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Irf7
interferon regulatory factor 7
decreases expression
ISO
Theophylline results in decreased expression of IRF7 mRNA
CTD
PMID:16083514
NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832
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Irs1
insulin receptor substrate 1
increases expression
ISO
Theophylline results in increased expression of IRS1 mRNA
CTD
PMID:16083514
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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Itfg1
integrin alpha FG-GAP repeat containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ITFG1 protein
CTD
PMID:18951874
NCBI chr19:37,383,982...37,504,523
Ensembl chr19:21,210,733...21,331,279
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Itgam
integrin subunit alpha M
multiple interactions
ISO
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]
CTD
PMID:9762784
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
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Itgb2
integrin subunit beta 2
increases expression
ISO
Theophylline results in increased expression of ITGB2 mRNA
CTD
PMID:16083514
NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600
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Itm2b
integral membrane protein 2B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ITM2B protein
CTD
PMID:18951874
NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
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Jade1
jade family PHD finger 1
increases expression
ISO
Theophylline results in increased expression of JADE1 mRNA
CTD
PMID:18951874
NCBI chr 2:124,543,233...124,596,361
Ensembl chr 2:124,543,286...124,596,354
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Jak1
Janus kinase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein
CTD
PMID:18951874
NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926
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Kcnc3
potassium voltage-gated channel subfamily C member 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KCNC3 protein
CTD
PMID:18951874
NCBI chr 1:104,217,472...104,231,677
Ensembl chr 1:95,080,960...95,095,160
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Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KCNMB4 protein
CTD
PMID:18951874
NCBI chr 7:53,952,150...54,005,101
Ensembl chr 7:52,066,136...52,119,278
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Kdm4b
lysine demethylase 4B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KDM4B protein
CTD
PMID:18951874
NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,158,752...1,236,543
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Kdm6b
lysine demethylase 6B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KDM6B protein
CTD
PMID:18951874
NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,121,848...54,130,794
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Kif1b
kinesin family member 1B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIF1B protein
CTD
PMID:18951874
NCBI chr 5:164,890,778...165,025,848
Ensembl chr 5:159,561,271...159,742,778
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Kin
Kin17 DNA and RNA binding protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIN protein
CTD
PMID:18951874
NCBI chr17:73,323,189...73,333,542
Ensembl chr17:68,413,486...68,423,845
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Klhl7
kelch-like family member 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KLHL7 protein
CTD
PMID:18951874
NCBI chr 4:11,898,766...11,947,796
Ensembl chr 4:11,006,375...11,055,541
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Krt8
keratin 8
increases expression
EXP
Theophylline results in increased expression of KRT8 mRNA
CTD
PMID:17522070
NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728
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Lamc1
laminin subunit gamma 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LAMC1 protein
CTD
PMID:18951874
NCBI chr13:67,924,872...68,051,986
Ensembl chr13:65,374,372...65,501,492
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Lbp
lipopolysaccharide binding protein
increases expression
EXP
Theophylline results in increased expression of LBP mRNA
CTD
PMID:17522070
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
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Letm2
leucine zipper and EF-hand containing transmembrane protein 2
decreases expression
ISO
Theophylline results in decreased expression of LETM2 mRNA
CTD
PMID:18951874
NCBI chr16:66,464,958...66,489,640
Ensembl chr16:66,469,111...66,489,704
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Lgals3
galectin 3
increases expression
EXP
Theophylline results in increased expression of LGALS3 mRNA
CTD
PMID:17522070
NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025
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Lhfpl6
LHFPL tetraspan subfamily member 6
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LHFPL6 protein Theophylline results in decreased expression of LHFPL6 mRNA
CTD
PMID:18951874
NCBI chr 2:137,126,485...137,324,442
Ensembl chr 2:137,126,509...137,324,443
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Limk1
LIM domain kinase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LIMK1 protein
CTD
PMID:18951874
NCBI chr12:27,663,177...27,697,085
Ensembl chr12:22,026,672...22,060,606
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Lipc
lipase C, hepatic type
decreases expression
EXP
Theophylline results in decreased expression of LIPC mRNA
CTD
PMID:17522070
NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464
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Lipe
lipase E, hormone sensitive type
multiple interactions increases activity affects localization
ISO EXP
Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein] Theophylline results in increased activity of LIPE protein Theophylline affects the localization of LIPE protein
CTD
PMID:7155675 PMID:11160373
NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310
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Lpl
lipoprotein lipase
increases expression
ISO
Theophylline results in increased expression of LPL mRNA
CTD
PMID:16083514
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
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Lrrc23
leucine rich repeat containing 23
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LRRC23 protein
CTD
PMID:18951874
NCBI chr 4:159,267,572...159,277,764
Ensembl chr 4:157,581,291...157,591,860
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Lsm8
LSM8 homolog, U6 small nuclear RNA associated
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LSM8 protein
CTD
PMID:18951874
NCBI chr 4:48,272,128...48,277,994
Ensembl chr 4:47,306,295...47,314,293
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Lst1
leukocyte specific transcript 1
increases expression
ISO
Theophylline results in increased expression of LST1 mRNA
CTD
PMID:16083514
NCBI chr20:3,639,353...3,644,399
Ensembl chr20:3,634,749...3,637,997
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Ltb
lymphotoxin beta
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LTB protein
CTD
PMID:18951874
NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381
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Ltc4s
leukotriene C4 synthase
decreases secretion
ISO
Theophylline results in decreased secretion of LTC4S protein
CTD
PMID:16083514
NCBI chr10:35,060,002...35,066,466
Ensembl chr10:34,560,360...34,562,651
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Ltf
lactotransferrin
decreases expression
ISO
Theophylline results in decreased expression of LTF protein
CTD
PMID:12016098
NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795
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Lyplal1
lysophospholipase-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LYPLAL1 protein
CTD
PMID:18951874
NCBI chr13:100,158,060...100,189,339
Ensembl chr13:97,626,451...97,657,867
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Theophylline results in increased phosphorylation of MAPK1 protein
CTD
PMID:32001318
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MAPK1IP1L protein
CTD
PMID:18951874
NCBI chr15:20,545,043...20,571,466
Ensembl chr15:20,545,059...20,569,674
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Theophylline results in increased phosphorylation of MAPK3 protein
CTD
PMID:32001318
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mapk7
mitogen-activated protein kinase 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MAPK7 protein
CTD
PMID:18951874
NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,170,167...46,176,267
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Mdh1
malate dehydrogenase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MDH1 protein
CTD
PMID:18951874
NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925
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Mecom
MDS1 and EVI1 complex locus
increases expression
ISO
Theophylline results in increased expression of MECOM mRNA
CTD
PMID:16083514
NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:112,909,321...113,464,590
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Med13l
mediator complex subunit 13L
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MED13L protein
CTD
PMID:18951874
NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473
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Med16
mediator complex subunit 16
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MED16 protein
CTD
PMID:18951874
NCBI chr 7:10,449,273...10,461,797
Ensembl chr 7:9,798,668...9,811,172
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Mef2a
myocyte enhancer factor 2a
decreases expression
ISO
Theophylline results in decreased expression of MEF2A mRNA
CTD
PMID:18951874
NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:120,850,080...120,981,948
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Mettl15
methyltransferase 15, mitochondrial 12S rRNA N4-cytidine
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of METTL15 protein
CTD
PMID:18951874
NCBI chr 3:95,586,855...95,764,392
Ensembl chr 3:95,586,850...95,764,397
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Mfsd10
major facilitator superfamily domain containing 10
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MFSD10 protein
CTD
PMID:18951874
NCBI chr14:76,103,762...76,107,385
Ensembl chr14:76,103,815...76,107,377
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Mgst2
microsomal glutathione S-transferase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MGST2 protein
CTD
PMID:18951874
NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:135,693,557...135,715,828
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Milr1
mast cell immunoglobulin-like receptor 1
decreases expression
ISO
Theophylline results in decreased expression of MILR1 mRNA
CTD
PMID:18951874
NCBI chr10:92,184,002...92,205,001
Ensembl chr10:91,687,831...91,705,282
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
Theophylline results in increased expression of MITF protein
CTD
PMID:32001318
NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145
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Mmab
metabolism of cobalamin associated B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MMAB protein
CTD
PMID:18951874
NCBI chr12:47,819,757...47,833,127
Ensembl chr12:42,159,089...42,172,490
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Mon1b
MON1 homolog B, secretory trafficking associated
decreases expression
ISO
Theophylline results in decreased expression of MON1B mRNA
CTD
PMID:18951874
NCBI chr19:58,526,503...58,534,478
Ensembl chr19:41,617,364...41,625,347
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Mosmo
modulator of smoothened
increases expression
ISO
Theophylline results in increased expression of MOSMO mRNA
CTD
PMID:18951874
NCBI chr 1:175,217,680...175,288,521
Ensembl chr 1:175,217,545...175,288,334
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Mphosph6
M phase phosphoprotein 6
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MPHOSPH6 protein
CTD
PMID:18951874
NCBI chr19:62,768,909...62,778,874
Ensembl chr19:45,860,154...45,870,170
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Mpo
myeloperoxidase
decreases expression multiple interactions
ISO EXP
Theophylline results in decreased expression of MPO protein Theophylline inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:12016098 PMID:16133968
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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Mtg2
mitochondrial ribosome-associated GTPase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTG2 protein
CTD
PMID:18951874
NCBI chr 3:167,165,542...167,181,358
Ensembl chr 3:167,165,982...167,181,358
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Mtif3
mitochondrial translational initiation factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTIF3 protein
CTD
PMID:18951874
NCBI chr12:8,126,193...8,140,706
Ensembl chr12:8,126,276...8,140,470
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Mto1
mitochondrial tRNA translation optimization 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTO1 protein
CTD
PMID:18951874
NCBI chr 8:88,188,918...88,215,516
Ensembl chr 8:79,309,982...79,335,231
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
decreases expression
ISO
Theophylline results in decreased expression of MUC5B mRNA
CTD
PMID:16083514
NCBI chr 1:206,346,400...206,378,367
Ensembl chr 1:196,916,825...196,949,250
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Mug1
murinoglobulin 1
decreases expression
EXP
Theophylline results in decreased expression of MUG1 mRNA
CTD
PMID:17522070
NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression affects expression decreases expression
ISO EXP
[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein] Theophylline results in increased expression of MYC mRNA mutant form; Theophylline results in increased expression of MYC protein Theophylline affects the expression of MYC mRNA Theophylline results in decreased expression of MYC mRNA
CTD
PMID:8416737 PMID:8822937 PMID:17522070
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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Myo19
myosin XIX
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MYO19 protein
CTD
PMID:18951874
NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
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Mzt1
mitotic spindle organizing protein 1
decreases expression
ISO
Theophylline results in decreased expression of MZT1 mRNA
CTD
PMID:18951874
NCBI chr15:75,787,281...75,797,589
Ensembl chr15:75,786,994...75,797,589
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N4bp2l2
NEDD4 binding protein 2-like 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of N4BP2L2 protein
CTD
PMID:18951874
NCBI chr12:4,972,967...5,038,027
Ensembl chr12:103,590...197,784
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Nacc2
NACC family member 2
increases expression
ISO
Theophylline results in increased expression of NACC2 mRNA
CTD
PMID:18951874
NCBI chr 3:29,278,077...29,345,098
Ensembl chr 3:8,883,065...8,946,660
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Napepld
N-acyl phosphatidylethanolamine phospholipase D
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NAPEPLD protein
CTD
PMID:18951874
NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:13,361,006...13,398,748
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Nbeal1
neurobeachin-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NBEAL1 protein
CTD
PMID:18951874
NCBI chr 9:69,069,326...69,237,932
Ensembl chr 9:61,575,356...61,736,750
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Nck2
NCK adaptor protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NCK2 protein
CTD
PMID:18951874
NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:45,714,883...45,840,307
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Ndufb2
NADH:ubiquinone oxidoreductase subunit B2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NDUFB2 protein
CTD
PMID:18951874
NCBI chr 4:69,334,307...69,341,394
Ensembl chr15:46,536,062...46,536,851 Ensembl chr 4:46,536,062...46,536,851
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Nedd4l
NEDD4 like E3 ubiquitin protein ligase
increases expression
ISO
Theophylline results in increased expression of NEDD4L mRNA
CTD
PMID:16083514
NCBI chr18:60,663,918...60,996,824
Ensembl chr18:58,393,509...58,723,137
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Theophylline inhibits the reaction [TNF protein affects the localization of NFKB1 protein]
CTD
PMID:10344522
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
affects expression decreases degradation
ISO
Theophylline affects the expression of NFKBIA protein Theophylline results in decreased degradation of NFKBIA protein
CTD
PMID:11770011 PMID:12065913
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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Nkapd1
NKAP domain containing 1
increases expression
ISO
Theophylline results in increased expression of NKAPD1 mRNA
CTD
PMID:18951874
NCBI chr 8:50,955,650...50,966,915
Ensembl chr 8:50,955,654...50,966,830
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Nlk
nemo like kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NLK protein
CTD
PMID:18951874
NCBI chr10:63,965,432...64,089,006
Ensembl chr10:63,438,222...63,589,730
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Nnt
nicotinamide nucleotide transhydrogenase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NNT protein
CTD
PMID:18951874
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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Nop10
NOP10 ribonucleoprotein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NOLA3 protein
CTD
PMID:18951874
NCBI chr 3:99,066,857...99,067,942
Ensembl chr 3:99,066,857...99,067,942
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
Theophylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]
CTD
PMID:16133968
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Nqo2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NQO2 protein
CTD
PMID:18951874
NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320
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Nrep
neuronal regeneration related protein
decreases expression
ISO
Theophylline results in decreased expression of NREP mRNA
CTD
PMID:18951874
NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,017,083...25,046,591
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Nrxn3
neurexin 3
increases expression
ISO
Theophylline results in increased expression of NRXN3 mRNA
CTD
PMID:16083514
NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044
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Ns5atp4
NS5A transactivated protein 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C1ORF43 protein
CTD
PMID:18951874
NCBI chr 2:177,792,070...177,804,943
Ensembl chr 2:175,494,304...175,510,663
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Nsd3
nuclear receptor binding SET domain protein 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NSD3 protein
CTD
PMID:18951874
NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423
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Nsun4
NOP2/Sun RNA methyltransferase 4
increases expression
ISO
Theophylline results in increased expression of NSUN4 mRNA
CTD
PMID:18951874
NCBI chr 5:129,511,224...129,532,498
Ensembl chr 5:129,512,307...129,532,423 Ensembl chr 5:129,512,307...129,532,423
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Ntaq1
N-terminal glutamine amidase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NTAQ1 protein
CTD
PMID:18951874
NCBI chr 7:89,684,318...89,704,484
Ensembl chr 7:89,684,323...89,704,474
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Nts
neurotensin
multiple interactions
EXP
Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]
CTD
PMID:10199625
NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423
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Nup50
nucleoporin 50
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NUP50 protein
CTD
PMID:18951874
NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
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Nutf2
nuclear transport factor 2
increases expression
ISO
Theophylline results in increased expression of NUTF2 mRNA
CTD
PMID:16083514
NCBI chr19:50,662,168...50,683,457
Ensembl chr19:33,752,291...33,773,591
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Ociad1
OCIA domain containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OCIAD1 protein
CTD
PMID:18951874
NCBI chr14:34,897,851...34,915,291
Ensembl chr14:34,897,847...34,915,286
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Or4n4
olfactory receptor family 4 subfamily N member 4
increases expression
ISO
Theophylline results in increased expression of OR4N4 mRNA
CTD
PMID:18951874
NCBI chr15:23,494,563...23,495,554
Ensembl chr15:23,492,445...23,498,563
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Osbp
oxysterol binding protein
increases expression
ISO
Theophylline results in increased expression of OSBP mRNA
CTD
PMID:16083514
NCBI chr 1:218,313,455...218,343,263
Ensembl chr 1:208,887,895...208,918,506
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Otc
ornithine transcarbamylase
decreases expression
EXP
Theophylline results in decreased expression of OTC mRNA
CTD
PMID:17522070
NCBI chr X:15,126,358...15,202,473
Ensembl chr X:12,453,834...12,566,918
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Otp
orthopedia homeobox
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of OTP protein; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OTP protein
CTD
PMID:18951874
NCBI chr 2:27,842,892...27,851,093
Ensembl chr 2:26,108,163...26,116,359
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Pan3
poly(A) specific ribonuclease subunit PAN3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PAN3 protein
CTD
PMID:18951874
NCBI chr12:7,476,707...7,595,384
Ensembl chr12:7,476,697...7,599,204
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Parp1
poly (ADP-ribose) polymerase 1
affects binding multiple interactions
ISO
Theophylline binds to PARP1 protein [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]
CTD
PMID:9454737 PMID:18951874
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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Pbrm1
polybromo 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PB1 protein
CTD
PMID:18951874
NCBI chr16:6,219,933...6,319,336
Ensembl chr16:6,213,300...6,311,780
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Pcp4l1
Purkinje cell protein 4-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PCP4L1 protein
CTD
PMID:18951874
NCBI chr13:86,121,463...86,145,097
Ensembl chr13:83,588,992...83,609,966
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Pcsk5
proprotein convertase subtilisin/kexin type 5
increases expression
ISO
Theophylline results in increased expression of PCSK5 mRNA
CTD
PMID:16083514
NCBI chr 1:224,263,823...224,694,350
Ensembl chr 1:214,837,927...215,267,600
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Pde3a
phosphodiesterase 3A
increases expression
EXP
Theophylline results in increased expression of PDE3A mRNA
CTD
PMID:16651698
NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:174,172,868...174,438,274
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Pdss2
decaprenyl diphosphate synthase subunit 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PDSS2 protein
CTD
PMID:18951874
NCBI chr20:46,709,631...46,938,704
Ensembl chr20:46,709,649...46,938,708
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Pea15
proliferation and apoptosis adaptor protein 15
decreases expression
ISO
Theophylline results in decreased expression of PEA15 mRNA
CTD
PMID:16083514
NCBI chr13:87,190,189...87,199,811
Ensembl chr13:84,654,870...84,667,499
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Pex7
peroxisomal biogenesis factor 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PEX7 protein
CTD
PMID:18951874
NCBI chr 1:16,402,319...16,466,304
Ensembl chr 1:14,582,699...14,646,748
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Pias1
protein inhibitor of activated STAT, 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS1 protein
CTD
PMID:18951874
NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:63,338,150...63,438,905
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Pias2
protein inhibitor of activated STAT, 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS2 protein
CTD
PMID:18951874
NCBI chr18:72,883,008...72,989,486
Ensembl chr18:70,607,665...70,710,033
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Picalm
phosphatidylinositol binding clathrin assembly protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PICALM protein
CTD
PMID:18951874
NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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Pigc
phosphatidylinositol glycan anchor biosynthesis, class C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIGC protein
CTD
PMID:18951874
NCBI chr13:76,876,894...76,879,420
Ensembl chr13:74,296,854...74,346,211
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Pipox
pipecolic acid and sarcosine oxidase
decreases expression
ISO
Theophylline results in decreased expression of PIPOX mRNA
CTD
PMID:18951874
NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370
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Pitpnb
phosphatidylinositol transfer protein, beta
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PITPNB protein
CTD
PMID:18951874
NCBI chr12:50,909,140...50,958,193
Ensembl chr12:45,249,333...45,298,314
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Pkhd1
PKHD1 ciliary IPT domain containing fibrocystin/polyductin
decreases expression
ISO
Theophylline results in decreased expression of PKHD1 mRNA
CTD
PMID:18951874
NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381
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Pklr
pyruvate kinase L/R
decreases expression
EXP
Theophylline results in decreased expression of PKLR mRNA
CTD
PMID:17522070
NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870
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Plcb1
phospholipase C beta 1
multiple interactions decreases expression
EXP
Theophylline inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein] Theophylline results in decreased expression of PLCB1 protein
CTD
PMID:15998294
NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869
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Pld3
phospholipase D family, member 3
increases expression
ISO
Theophylline results in increased expression of PLD3 mRNA
CTD
PMID:16083514
NCBI chr 1:91,949,465...91,971,834
Ensembl chr 1:82,821,875...82,844,072
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Plekha1
pleckstrin homology domain containing A1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PLEKHA1 protein
CTD
PMID:18951874
NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156
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Plrg1
pleiotropic regulator 1
increases expression
ISO
Theophylline results in increased expression of PLRG1 mRNA
CTD
PMID:18951874
NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522
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Polr1b
RNA polymerase I subunit B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of POLR1B protein
CTD
PMID:18951874
NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:116,333,889...116,358,379
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Polr2f
RNA polymerase II, I and III subunit F
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR2F protein
CTD
PMID:18951874
NCBI chr 7:112,592,977...112,604,681
Ensembl chr 7:110,712,572...110,724,234
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Polr3h
RNA polymerase III subunit H
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR3H protein
CTD
PMID:18951874
NCBI chr 7:115,309,571...115,319,881
Ensembl chr 7:113,429,451...113,439,778
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Polr3k
RNA polymerase III subunit K
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR3K protein
CTD
PMID:18951874
NCBI chr 3:168,982,846...168,987,043
Ensembl chr 3:168,982,812...168,987,040
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Pomc
proopiomelanocortin
multiple interactions
EXP
[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP; INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]
CTD
PMID:4306506
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
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Pon1
paraoxonase 1
decreases activity
ISO
Theophylline results in decreased activity of PON1 protein
CTD
PMID:31581362
NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPARA protein
CTD
PMID:18951874
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Theophylline results in increased expression of PPARG mRNA; Theophylline results in increased expression of PPARG protein
CTD
PMID:16569937
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
decreases expression
ISO
Theophylline results in decreased expression of PPP2CA mRNA
CTD
PMID:16083514
NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862
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Ppp3cb
protein phosphatase 3 catalytic subunit beta
decreases expression
ISO
Theophylline results in decreased expression of PPP3CB mRNA
CTD
PMID:16083514
NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,760,030...3,804,981
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Ppp4r3b
protein phosphatase 4, regulatory subunit 3B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPP4R3B protein
CTD
PMID:18951874
NCBI chr14:107,118,116...107,166,121
Ensembl chr14:102,917,443...103,068,192
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Prim2
DNA primase subunit 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRIM2 protein
CTD
PMID:18951874
NCBI chr 9:43,188,350...43,400,482
Ensembl chr 9:35,692,376...35,903,030
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
decreases expression
ISO
Theophylline results in decreased expression of PRKAA1 mRNA
CTD
PMID:18951874
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PRKACA protein
CTD
PMID:18951874
NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430
G
Prkca
protein kinase C, alpha
decreases expression
ISO
Theophylline results in decreased expression of PRKCA mRNA
CTD
PMID:16083514
NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
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Prkra
protein activator of interferon induced protein kinase EIF2AK2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRKRA protein
CTD
PMID:18951874
NCBI chr 3:81,982,669...82,002,028
Ensembl chr 3:61,575,447...61,594,347
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Prlr
prolactin receptor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PRLR protein
CTD
PMID:18951874
NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:59,134,588...59,324,718
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Proser3
proline and serine rich 3
increases expression
ISO
Theophylline results in increased expression of PROSER3 mRNA
CTD
PMID:18951874
NCBI chr 1:85,793,363...85,806,682
Ensembl chr 1:85,793,358...85,805,909
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Prpf38b
pre-mRNA processing factor 38B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRPF38B protein
CTD
PMID:18951874
NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
G
Psmb1
proteasome 20S subunit beta 1
affects expression
EXP
Theophylline affects the expression of PSMB1 mRNA
CTD
PMID:16988215
NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:56,420,618...56,463,560
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Psmb10
proteasome 20S subunit beta 10
affects expression
EXP
Theophylline affects the expression of PSMB10 mRNA
CTD
PMID:16988215
NCBI chr19:50,740,808...50,743,292
Ensembl chr19:33,827,229...33,833,626
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Psmb2
proteasome 20S subunit beta 2
affects expression
EXP
Theophylline affects the expression of PSMB2 mRNA
CTD
PMID:16988215
NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
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Psmb5
proteasome 20S subunit beta 5
affects expression
EXP
Theophylline affects the expression of PSMB5 mRNA
CTD
PMID:16988215
NCBI chr15:32,042,784...32,047,379
Ensembl chr15:28,072,781...28,077,440
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Psmb8
proteasome 20S subunit beta 8
affects expression
EXP
Theophylline affects the expression of PSMB8 mRNA
CTD
PMID:16988215
NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,652,159...4,655,283
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Psmb9
proteasome 20S subunit beta 9
affects expression
EXP
Theophylline affects the expression of PSMB9 mRNA
CTD
PMID:16988215
NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,666,046...4,672,512
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Pth
parathyroid hormone
multiple interactions increases expression
EXP
Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein]
CTD
PMID:26851681
NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530
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Ptma
prothymosin alpha
decreases expression
EXP
Theophylline results in decreased expression of PTMA mRNA
CTD
PMID:17522070
NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:87,176,230...87,180,333
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Ptp4a1
protein tyrosine phosphatase 4A1
decreases expression
ISO
Theophylline results in decreased expression of PTP4A1 mRNA
CTD
PMID:16083514
NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:33,214,208...33,221,964
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
increases expression
ISO
Theophylline results in increased expression of PTPN2 mRNA
CTD
PMID:18951874
NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627
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Ptpre
protein tyrosine phosphatase, receptor type, E
increases expression
ISO
Theophylline results in increased expression of PTPRE mRNA
CTD
PMID:18951874
NCBI chr 1:199,774,195...199,924,646
Ensembl chr 1:190,344,401...190,489,534
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Pycr2
pyrroline-5-carboxylate reductase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PYCR2 protein
CTD
PMID:18951874
NCBI chr13:92,626,462...92,630,256
Ensembl chr13:92,626,471...92,634,184
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Rab11b
RAB11B, member RAS oncogene family
increases expression
ISO
Theophylline results in increased expression of RAB11B mRNA
CTD
PMID:18951874
NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:14,521,368...14,534,593
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Rab21
RAB21, member RAS oncogene family
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RAB21 protein
CTD
PMID:18951874
NCBI chr 7:52,790,158...52,814,943
Ensembl chr 7:50,904,057...50,928,839
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Rad9a
RAD9 checkpoint clamp component A
decreases expression
ISO
Theophylline results in decreased expression of RAD9A mRNA
CTD
PMID:16083514
NCBI chr 1:210,917,970...210,983,038
Ensembl chr 1:201,487,136...201,553,608
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Rangrf
RAN guanine nucleotide release factor
increases expression
ISO
Theophylline results in increased expression of RANGRF mRNA
CTD
PMID:18951874
NCBI chr10:54,176,325...54,177,696
Ensembl chr10:53,677,467...53,678,840
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Rasal2
RAS protein activator like 2
decreases expression
ISO
Theophylline results in decreased expression of RASAL2 mRNA
CTD
PMID:18951874
NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940
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Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein]; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RB1 protein
CTD
PMID:9454737 PMID:18951874
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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Rbm8a
RNA binding motif protein 8A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RBM8A protein
CTD
PMID:18951874
NCBI chr 2:186,854,018...186,856,802
Ensembl chr 2:184,165,193...184,167,959
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Rc3h1
ring finger and CCCH-type domains 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RC3H1 protein
CTD
PMID:18951874
NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839
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Rcan1
regulator of calcineurin 1
increases expression
ISO
Theophylline results in increased expression of RCAN1 mRNA
CTD
PMID:16083514
NCBI chr11:45,108,123...45,188,065
Ensembl chr11:31,622,210...31,702,045
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Rcc1l
RCC1 like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RCC1L protein
CTD
PMID:18951874
NCBI chr12:22,543,125...22,574,042
Ensembl chr12:22,543,734...22,574,036
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Rdh10
retinol dehydrogenase 10
increases expression
ISO
Theophylline results in increased expression of RDH10 mRNA
CTD
PMID:18951874
NCBI chr 5:7,969,931...7,998,834
Ensembl chr 5:3,188,445...3,215,572
G
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RECK protein
CTD
PMID:18951874
NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:58,102,981...58,169,502
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions affects localization
ISO
Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein] Theophylline affects the localization of RELA protein
CTD
PMID:11770011
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Ren
renin
affects expression
ISO
Theophylline affects the expression of REN protein
CTD
PMID:7743391
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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Rfk
riboflavin kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFK protein
CTD
PMID:18951874
NCBI chr 1:224,226,632...224,234,185
Ensembl chr 1:214,799,825...214,807,438 Ensembl chr X:214,799,825...214,807,438
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Rftn1
raftlin lipid raft linker 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFTN1 protein
CTD
PMID:18951874
NCBI chr 9:18,302,143...18,499,819
Ensembl chr 9:10,804,611...11,002,084
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Rfx7
regulatory factor X, 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RFX7 protein
CTD
PMID:18951874
NCBI chr 8:82,134,747...82,219,898
Ensembl chr 8:73,254,051...73,339,209
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Rgs16
regulator of G-protein signaling 16
increases expression
ISO
Theophylline results in increased expression of RGS16 mRNA
CTD
PMID:16083514
NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857
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Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RHNO1 protein
CTD
PMID:18951874
NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371
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Rhot2
ras homolog family member T2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein
CTD
PMID:18951874
NCBI chr10:15,363,467...15,369,263
Ensembl chr10:14,858,956...14,864,751
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Ric3
RIC3 acetylcholine receptor chaperone
affects binding
ISO
Theophylline binds to RIC3 protein
CTD
PMID:18951874
NCBI chr 1:163,030,621...163,086,583
Ensembl chr 1:163,032,158...163,086,519
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Riok3
RIO kinase 3
decreases expression
ISO
Theophylline results in decreased expression of RIOK3 mRNA
CTD
PMID:16083514
NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,327,776...3,353,343
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Ripk3
receptor-interacting serine-threonine kinase 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RIPK3 protein
CTD
PMID:18951874
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121
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Rmnd5a
required for meiotic nuclear division 5 homolog A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RMND5A protein
CTD
PMID:18951874
NCBI chr 4:104,934,160...104,991,088
Ensembl chr 4:103,379,908...103,433,051
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Rnaset2
ribonuclease T2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RNASET2 protein
CTD
PMID:18951874
NCBI chr 1:55,133,532...55,150,701
Ensembl chr 1:52,585,929...52,603,147
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Rps15
ribosomal protein S15
decreases expression
ISO
Theophylline results in decreased expression of RPS15 mRNA
CTD
PMID:18951874
NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:9,416,004...9,417,450 Ensembl chr 7:9,416,004...9,417,450
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Sbspon
somatomedin B and thrombospondin, type 1 domain containing
decreases expression
ISO
Theophylline results in decreased expression of SBSPON mRNA
CTD
PMID:18951874
NCBI chr 5:8,186,004...8,216,576
Ensembl chr 5:3,402,648...3,435,420
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Sds
serine dehydratase
increases expression
ISO
Theophylline results in increased expression of SDS mRNA
CTD
PMID:16083514
NCBI chr12:41,743,796...41,751,108
Ensembl chr12:36,083,229...36,088,203
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Secisbp2
SECIS binding protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SECISBP2 protein
CTD
PMID:18951874
NCBI chr17:13,690,263...13,721,303
Ensembl chr17:13,538,513...13,569,523
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Sell
selectin L
multiple interactions
ISO
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]
CTD
PMID:9762784
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456
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Serpina1
serpin family A member 1
affects response to substance
ISO
SERPINA1 gene affects the susceptibility to Theophylline
CTD
PMID:17943569
NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339
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Setd2
SET domain containing 2, histone lysine methyltransferase
decreases expression
ISO
Theophylline results in decreased expression of SETD2 mRNA
CTD
PMID:18951874
NCBI chr 8:119,390,207...119,475,863
Ensembl chr 8:110,511,772...110,597,489
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Sftpb
surfactant protein B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SFTPB protein
CTD
PMID:18951874
NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:104,359,396...104,368,436
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Sh2d2a
SH2 domain containing 2A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SH2D2A protein
CTD
PMID:18951874
NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:173,312,253...173,318,810
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Sh3rf1
SH3 domain containing ring finger 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SH3RF1 protein
CTD
PMID:18951874
NCBI chr16:33,746,396...33,912,127
Ensembl chr16:28,735,440...28,901,644
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Shprh
SNF2 histone linker PHD RING helicase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SHPRH protein
CTD
PMID:18951874
NCBI chr 1:7,349,073...7,422,804
Ensembl chr 1:5,528,888...5,602,527
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Sike1
suppressor of IKBKE 1
increases expression
ISO
Theophylline results in increased expression of SIKE1 mRNA
CTD
PMID:18951874
NCBI chr 2:190,518,002...190,525,833
Ensembl chr 2:190,518,002...190,525,832
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Sirt2
sirtuin 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein
CTD
PMID:18951874
NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975
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Skic3
SKI3 subunit of superkiller complex
decreases expression
ISO
Theophylline results in decreased expression of SKIC3 mRNA
CTD
PMID:18951874
NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626
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Slc12a8
solute carrier family 12, member 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein
CTD
PMID:18951874
NCBI chr11:80,622,000...80,771,674
Ensembl chr11:67,116,877...67,266,834
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Slc12a9
solute carrier family 12, member 9
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SLC12A9 protein
CTD
PMID:18951874
NCBI chr12:25,005,741...25,022,628
Ensembl chr12:19,369,004...19,385,877
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Slc16a1
solute carrier family 16 member 1
multiple interactions
ISO
Theophylline inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates]
CTD
PMID:19023563
NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611
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Slc25a24
solute carrier family 25 member 24
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC25A24 protein
CTD
PMID:18951874
NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231
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Slc39a9
solute carrier family 39, member 9
increases expression
ISO
Theophylline results in increased expression of SLC39A9 mRNA
CTD
PMID:18951874
NCBI chr 6:106,022,858...106,061,734
Ensembl chr 6:100,291,573...100,330,408
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Slc5a5
solute carrier family 5 member 5
increases expression
ISO
Theophylline results in increased expression of SLC5A5 protein
CTD
PMID:19409042
NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697
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Slco1b2
solute carrier organic anion transporter family member 1B2
increases expression
EXP
Theophylline results in increased expression of SLCO1B2 mRNA
CTD
PMID:17522070
NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981
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Slmap
sarcolemma associated protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLMAP protein
CTD
PMID:18951874
NCBI chr16:1,673,964...1,791,902
Ensembl chr16:1,667,208...1,785,149
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Smad2
SMAD family member 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein
CTD
PMID:18951874
NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
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Smad5
SMAD family member 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein
CTD
PMID:18951874
NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,864,720...7,891,634
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Smim7
small integral membrane protein 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SMIM7 protein
CTD
PMID:18951874
NCBI chr16:17,308,466...17,312,384
Ensembl chr16:17,273,258...17,278,336
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Smu1
SMU1, DNA replication regulator and spliceosomal factor
increases expression
ISO
Theophylline results in increased expression of SMU1 mRNA
CTD
PMID:18951874
NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300
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Snap23
synaptosome associated protein 23
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SNAP23 protein
CTD
PMID:18951874
NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:107,514,131...107,544,320
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Snx13
sorting nexin 13
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SNX13 protein
CTD
PMID:18951874
NCBI chr 6:51,758,258...51,862,260
Ensembl chr 6:51,753,036...51,860,224
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Spats2l
spermatogenesis associated, serine-rich 2-like
decreases expression
ISO
Theophylline results in decreased expression of SPATS2L mRNA
CTD
PMID:18951874
NCBI chr 9:66,814,217...66,988,084
Ensembl chr 9:59,320,276...59,493,967
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Spin2b
spindlin family member 2B
decreases expression
EXP
Theophylline results in decreased expression of SPIN2B mRNA
CTD
PMID:17522070
NCBI chr X:17,190,573...17,192,351
Ensembl chr X:17,180,474...17,192,351
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
Theophylline results in decreased expression of SREBF1 mRNA
CTD
PMID:17522070
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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Srr
serine racemase
decreases expression
ISO
Theophylline results in decreased expression of SRR mRNA
CTD
PMID:18951874
NCBI chr10:60,267,936...60,285,094
Ensembl chr10:59,769,571...59,787,011
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Srsf3
serine and arginine rich splicing factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SRSF3 protein
CTD
PMID:18951874
NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,091,910...7,101,078
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Ssr1
signal sequence receptor subunit 1
decreases expression
ISO
Theophylline results in decreased expression of SSR1 mRNA
CTD
PMID:16083514
NCBI chr17:27,039,203...27,067,352
Ensembl chr17:26,833,741...26,861,821
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Ssr3
signal sequence receptor subunit 3
increases expression
ISO
Theophylline results in increased expression of SSR3 mRNA
CTD
PMID:18951874
NCBI chr 2:151,915,101...151,935,162
Ensembl chr 2:149,605,005...149,625,132
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Sst
somatostatin
increases secretion
ISO
Theophylline results in increased secretion of SST protein
CTD
PMID:16601281
NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173
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St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ST3GAL3 protein
CTD
PMID:18951874
NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810
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Stam2
signal transducing adaptor molecule 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STAM2 protein
CTD
PMID:18951874
NCBI chr 3:37,186,145...37,234,810
Ensembl chr 3:37,186,145...37,234,812
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Stat3
signal transducer and activator of transcription 3
increases expression
ISO
Theophylline results in increased expression of STAT3 mRNA
CTD
PMID:16083514
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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Stk24
serine/threonine kinase 24
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STK24 protein
CTD
PMID:18951874
NCBI chr15:104,770,556...104,866,524
Ensembl chr15:98,365,791...98,460,553
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Stk35
serine/threonine kinase 35
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STK35 protein
CTD
PMID:18951874
NCBI chr 3:117,016,819...117,049,131
Ensembl chr 3:117,016,950...117,048,066
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Supt6h
SPT6 homolog, histone chaperone and transcription elongation factor
decreases expression
ISO
Theophylline results in decreased expression of SUPT6H mRNA
CTD
PMID:16083514
NCBI chr10:63,601,990...63,638,851
Ensembl chr10:63,103,921...63,140,780
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Tac1
tachykinin, precursor 1
multiple interactions
ISO
Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine]
CTD
PMID:1707400
NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178
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Taf1a
TATA-box binding protein associated factor, RNA polymerase I subunit A
increases expression
ISO
Theophylline results in increased expression of TAF1A mRNA
CTD
PMID:18951874
NCBI chr13:97,543,772...97,579,742
Ensembl chr13:95,029,225...95,048,087
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Taf7
TATA-box binding protein associated factor 7
decreases expression
ISO
Theophylline results in decreased expression of TAF7 mRNA
CTD
PMID:16083514
NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,452,943...29,462,134
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Tars2
threonyl-tRNA synthetase 2, mitochondrial
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TARS2 protein
CTD
PMID:18951874
NCBI chr 2:183,293,095...183,310,210
Ensembl chr 2:183,293,097...183,310,184
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Tas2r116
taste receptor, type 2, member 116
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TAS2R14 protein
CTD
PMID:18951874
NCBI chr 4:166,266,984...166,267,958
Ensembl chr 4:166,266,984...166,267,958
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Tbca
tubulin folding cofactor A
increases expression
ISO
Theophylline results in increased expression of TBCA mRNA
CTD
PMID:18951874
NCBI chr 2:27,745,985...27,800,624
Ensembl chr 2:26,011,795...26,065,907
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Tbxas1
thromboxane A synthase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TBXAS1 protein
CTD
PMID:18951874
NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096
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Tcf3
transcription factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TCF3 protein
CTD
PMID:18951874
NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314
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Tcn2
transcobalamin 2
increases expression
ISO
Theophylline results in increased expression of TCN2 mRNA
CTD
PMID:16083514
NCBI chr14:83,036,935...83,052,187
Ensembl chr14:78,813,343...78,828,489
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Tefm
transcription elongation factor, mitochondrial
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TEFM protein
CTD
PMID:18951874
NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486
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Tesk1
testis associated actin remodelling kinase 1
increases expression
ISO
Theophylline results in increased expression of TESK1 mRNA
CTD
PMID:16083514
NCBI chr 5:62,487,763...62,493,492
Ensembl chr 5:57,691,969...57,697,698
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
Theophylline inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Theophylline inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
CTD
PMID:16430859
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Tgif1
TGFB-induced factor homeobox 1
increases expression
ISO
Theophylline results in increased expression of TGIF1 mRNA
CTD
PMID:16083514
NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:110,720,921...110,757,802
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Thrsp
thyroid hormone responsive
decreases expression
EXP
Theophylline results in decreased expression of THRSP mRNA
CTD
PMID:17522070
NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Theophylline results in increased expression of TIMP1 mRNA
CTD
PMID:17522070
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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Tmc5
transmembrane channel-like 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMC5 protein
CTD
PMID:18951874
NCBI chr 1:182,349,102...182,433,679
Ensembl chr 1:172,914,457...172,999,474
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Tmed4
transmembrane p24 trafficking protein 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMED4 protein
CTD
PMID:18951874
NCBI chr14:85,338,980...85,343,577
Ensembl chr14:81,125,053...81,129,631
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Tmem106b
transmembrane protein 106B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMEM106B protein
CTD
PMID:18951874
NCBI chr 4:42,294,074...42,313,426
Ensembl chr 4:41,327,994...41,345,619
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Tmem19
transmembrane protein 19
decreases expression
ISO
Theophylline results in decreased expression of TMEM19 mRNA
CTD
PMID:18951874
NCBI chr 7:52,844,985...52,871,708
Ensembl chr 7:50,958,888...50,986,809
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Tmem243
transmembrane protein 243
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM243 protein
CTD
PMID:18951874
NCBI chr 4:24,950,791...24,968,642
Ensembl chr 4:24,950,791...24,968,642
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Tmem260
transmembrane protein 260
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM260 protein
CTD
PMID:18951874
NCBI chr15:24,213,658...24,287,242
Ensembl chr15:21,734,151...21,806,801
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Tmem63a
transmembrane protein 63a
decreases expression
ISO
Theophylline results in decreased expression of TMEM63A mRNA
CTD
PMID:18951874
NCBI chr13:95,194,323...95,227,944
Ensembl chr13:92,663,968...92,696,183
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Tmem80
transmembrane protein 80
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM80 protein
CTD
PMID:18951874
NCBI chr 1:196,435,999...196,444,368
Ensembl chr 1:196,436,003...196,444,367 Ensembl chr 1:196,436,003...196,444,367
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Tmem87b
transmembrane protein 87B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMEM87B protein
CTD
PMID:18951874
NCBI chr 3:116,061,933...116,097,421
Ensembl chr 3:116,062,204...116,097,367
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Tmx3
thioredoxin-related transmembrane protein 3
increases expression
ISO
Theophylline results in increased expression of TMX3 mRNA
CTD
PMID:18951874
NCBI chr18:86,021,137...86,054,025
Ensembl chr18:83,731,868...83,762,263
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Tnf
tumor necrosis factor
decreases secretion multiple interactions
ISO EXP
Theophylline results in decreased secretion of TNF protein Theophylline inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] [Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Theophylline inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]
CTD
PMID:8162974 PMID:10344522 PMID:11694023 PMID:11770011 PMID:16133968 PMID:18951874 PMID:20388727 More...
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tnfaip8
TNF alpha induced protein 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TNFAIP8 protein
CTD
PMID:18951874
NCBI chr18:45,370,334...45,486,036
Ensembl chr18:43,183,916...43,299,517
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Tp53
tumor protein p53
multiple interactions decreases expression
ISO EXP
[Theophylline co-treated with Chlorambucil] results in increased expression of TP53; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53] Theophylline results in decreased expression of TP53 Theophylline results in decreased expression of TP53 mRNA
CTD
PMID:8822937 PMID:17522070
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tpmt
thiopurine S-methyltransferase
increases expression
ISO
Theophylline results in increased expression of TPMT mRNA
CTD
PMID:16083514
NCBI chr17:17,850,308...17,868,976
Ensembl chr17:17,644,173...17,662,709
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Tpp2
tripeptidyl peptidase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TPP2 protein
CTD
PMID:18951874
NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:46,046,632...46,128,157
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Traf1
TNF receptor-associated factor 1
decreases expression
ISO
Theophylline results in decreased expression of TRAF1 mRNA
CTD
PMID:16083514
NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:18,222,054...18,241,807
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Trmt10a
tRNA methyltransferase 10A
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRMT10A protein Theophylline results in decreased expression of TRMT10A mRNA
CTD
PMID:18951874
NCBI chr 2:226,669,445...226,684,166
Ensembl chr 2:226,669,832...226,684,151
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Trmt13
tRNA methyltransferase 13 homolog
increases expression
ISO
Theophylline results in increased expression of TRMT13 mRNA
CTD
PMID:18951874
NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843
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Trmt61a
tRNA methyltransferase 61A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TRMT61A protein
CTD
PMID:18951874
NCBI chr 6:136,558,417...136,564,411
Ensembl chr 6:130,737,219...130,743,243
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Trpm7
transient receptor potential cation channel, subfamily M, member 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRPM7 protein
CTD
PMID:18951874
NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:114,046,258...114,135,190
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Ttc3
tetratricopeptide repeat domain 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTC3 protein
CTD
PMID:18951874
NCBI chr11:47,158,766...47,258,612
Ensembl chr11:33,688,952...33,788,975
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Ttll3
tubulin tyrosine ligase like 3
affects binding
ISO
Theophylline binds to TTLL3 protein
CTD
PMID:18951874
NCBI chr 4:146,532,958...146,558,425
Ensembl chr 4:146,533,953...146,557,889
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Ttn
titin
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTN protein
CTD
PMID:18951874
NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741
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Tuba1b
tubulin, alpha 1B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TUBA1B protein
CTD
PMID:18951874
NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:130,081,032...130,196,186
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Tubd1
tubulin, delta 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TUBD1 protein
CTD
PMID:18951874
NCBI chr10:71,865,446...71,888,731
Ensembl chr10:71,368,133...71,391,266
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Tusc3
tumor suppressor candidate 3
increases expression
ISO
Theophylline results in increased expression of TUSC3 mRNA
CTD
PMID:16083514
NCBI chr16:59,899,642...60,048,813
Ensembl chr16:53,196,195...53,344,781
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Tyr
tyrosinase
increases expression
ISO
Theophylline results in increased expression of TYR mRNA; Theophylline results in increased expression of TYR protein
CTD
PMID:21071833 PMID:32001318
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
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Tyrp1
tyrosinase-related protein 1
increases expression
ISO
Theophylline results in increased expression of TYRP1 protein
CTD
PMID:32001318
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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Uba1
ubiquitin-like modifier activating enzyme 1
affects expression
EXP
Theophylline affects the expression of UBA1 mRNA
CTD
PMID:16988215
NCBI chr X:4,062,216...4,084,192
Ensembl chr X:1,508,666...1,530,636
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Ube2d3
ubiquitin-conjugating enzyme E2D 3
affects expression
EXP
Theophylline affects the expression of UBE2D3 mRNA
CTD
PMID:16988215
NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:223,868,730...223,898,081
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Ubfd1
ubiquitin family domain containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UBFD1 protein
CTD
PMID:18951874
NCBI chr 1:186,057,267...186,068,832
Ensembl chr 1:176,625,657...176,640,993
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Ubqln2
ubiquilin 2
increases expression
ISO
Theophylline results in increased expression of UBQLN2 mRNA
CTD
PMID:16083514
NCBI chr X:21,228,809...21,232,228
Ensembl chr X:17,853,114...17,856,505
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Ubr3
ubiquitin protein ligase E3 component n-recognin 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UBR3 protein
CTD
PMID:18951874
NCBI chr 3:75,057,615...75,214,581
Ensembl chr 3:54,649,992...54,806,247
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Ubtf
upstream binding transcription factor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of UBTF protein
CTD
PMID:18951874
NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,258,217...87,272,969
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Uchl1
ubiquitin C-terminal hydrolase L1
affects expression
EXP
Theophylline affects the expression of UCHL1 mRNA
CTD
PMID:16988215
NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590
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Ufm1
ubiquitin-fold modifier 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UFM1 protein
CTD
PMID:18951874
NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:137,966,678...137,978,089 Ensembl chr 2:137,966,678...137,978,089
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Utp15
UTP15, small subunit processome component
increases expression
ISO
Theophylline results in increased expression of UTP15 mRNA
CTD
PMID:18951874
NCBI chr 2:31,329,222...31,347,022
Ensembl chr 2:29,594,941...29,612,773
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Uvrag
UV radiation resistance associated
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of UVRAG protein
CTD
PMID:18951874
NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:153,185,395...153,442,136
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Vegfc
vascular endothelial growth factor C
increases expression
ISO
Theophylline results in increased expression of VEGFC mRNA
CTD
PMID:16083514
NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848
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Vps26a
VPS26 retromer complex component A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of VPS26A protein
CTD
PMID:18951874
NCBI chr20:30,404,320...30,434,266
Ensembl chr20:30,404,325...30,434,131
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Vps35l
VPS35 endosomal protein sorting factor like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of VPS35L protein
CTD
PMID:18951874
NCBI chr 1:173,076,219...173,179,663
Ensembl chr 1:173,076,099...173,180,610
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Vsx1
visual system homeobox 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of VSX1 protein
CTD
PMID:18951874
NCBI chr 3:159,974,693...159,982,292
Ensembl chr 3:139,514,270...139,521,869
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Wdr20
WD repeat domain 20
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WDR20 protein
CTD
PMID:18951874
NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339
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Wtap
WT1 associated protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein
CTD
PMID:18951874
NCBI chr 1:50,070,973...50,096,074
Ensembl chr 1:47,665,965...47,691,065
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Wwox
WW domain-containing oxidoreductase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of WWOX protein; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WWOX protein
CTD
PMID:18951874
NCBI chr19:59,338,402...60,269,323
Ensembl chr19:42,432,152...43,359,391
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Xiap
X-linked inhibitor of apoptosis
increases expression
ISO
Theophylline results in increased expression of XIAP mRNA
CTD
PMID:18951874
NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700
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Xylb
xylulokinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of XYLB protein
CTD
PMID:18951874
NCBI chr 8:127,971,194...128,012,511
Ensembl chr 8:119,096,029...119,128,848
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Yap1
Yes1 associated transcriptional regulator
decreases expression
ISO
Theophylline results in decreased expression of YAP1 mRNA
CTD
PMID:18951874
NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010
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Yipf4
Yip1 domain family, member 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of YIPF4 protein
CTD
PMID:18951874
NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:20,950,501...20,962,229
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Yipf6
Yip1 domain family, member 6
increases expression
ISO
Theophylline results in increased expression of YIPF6 mRNA
CTD
PMID:18951874
NCBI chr X:68,079,754...68,091,845
Ensembl chr X:64,040,952...64,054,702
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Yju2b
YJU2 splicing factor homolog B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of YJU2B protein
CTD
PMID:18951874
NCBI chr19:40,799,392...40,810,885
Ensembl chr19:23,894,649...23,906,077
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Ythdc1
YTH N6-methyladenosine RNA binding protein C1
increases expression
ISO
Theophylline results in increased expression of YTHDC1 mRNA
CTD
PMID:18951874
NCBI chr14:21,540,276...21,570,724
Ensembl chr14:21,185,440...21,216,028
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Zbtb18
zinc finger and BTB domain containing 18
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZBTB18 protein
CTD
PMID:18951874
NCBI chr13:91,971,602...91,980,058
Ensembl chr13:89,439,420...89,448,862
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Zbtb25
zinc finger and BTB domain containing 25
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZBTB25 protein
CTD
PMID:18951874
NCBI chr 6:95,070,699...95,095,888
Ensembl chr 6:95,075,331...95,095,755
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Zbtb45
zinc finger and BTB domain containing 45
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZBTB45 protein
CTD
PMID:18951874
NCBI chr 1:82,707,633...82,712,926
Ensembl chr 1:73,635,448...73,639,556
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Zcchc10
zinc finger CCHC-type containing 10
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZCCHC10 protein
CTD
PMID:18951874
NCBI chr10:37,971,459...37,981,860
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Zdhhc11
zinc finger, DHHC-type containing 11
decreases expression
ISO
Theophylline results in decreased expression of ZDHHC11 mRNA
CTD
PMID:18951874
NCBI chr 1:31,124,900...31,156,075
Ensembl chr 1:29,296,334...29,326,898
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Zfand3
zinc finger AN1-type containing 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZFAND3 protein
CTD
PMID:18951874
NCBI chr20:8,084,898...8,281,093
Ensembl chr20:8,082,200...8,279,616
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Zfp24
zinc finger protein 24
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF24 protein
CTD
PMID:18951874
NCBI chr18:15,573,031...15,583,432
Ensembl chr18:15,298,290...15,306,799
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Zfp354a
zinc finger protein 354A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF354A protein
CTD
PMID:18951874
NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,396,231...35,408,068
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Zfp866
zinc finger protein 866
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF700 protein
CTD
PMID:18951874
NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,668,258...19,675,932
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Zfpl1
zinc finger protein-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZFPL1 protein
CTD
PMID:18951874
NCBI chr 1:212,803,790...212,807,803
Ensembl chr 1:203,374,504...203,378,487
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Zrsr2
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2
decreases expression
ISO
Theophylline results in decreased expression of ZRSR2 mRNA
CTD
PMID:18951874
NCBI chr X:34,179,279...34,201,989
Ensembl chr X:30,547,536...30,570,125
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Zxdc
ZXD family zinc finger C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZXDC protein
CTD
PMID:18951874
NCBI chr 4:122,882,389...122,914,486
Ensembl chr 4:122,882,336...122,916,496
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
increases expression
ISO
Aminophylline results in increased expression of ALDH18A1 mRNA
CTD
PMID:29901742
NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:239,375,669...239,407,890
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Aminophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein
CTD
PMID:15645133
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cat
catalase
multiple interactions
ISO
[Aminophylline co-treated with Photosensitizing Agents] promotes the reaction [Benzo(a)pyrene results in increased expression of CAT protein]
CTD
PMID:30776357
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Gcg
glucagon
increases secretion
EXP
Aminophylline results in increased secretion of GCG protein
CTD
PMID:1248788
NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929
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Hrh1
histamine receptor H 1
multiple interactions
ISO
[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
CTD
PMID:16129921
NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455
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Ins1
insulin 1
increases secretion
EXP
Aminophylline results in increased secretion of INS1 protein
CTD
PMID:1248788
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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