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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-hydroxytryptophan
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Accession:CHEBI:28171 term browser browse the term
Definition:A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Synonyms:exact_synonym: 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
 related_synonym: 5-HTP;   5-hydroxy-DL-tryptophan;   5-hydroxytryptophan DL-form;   DL-5-HTP;   DL-5-hydroxytryptophan;   Formula=C11H12N2O3;   InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16);   InChIKey=LDCYZAJDBXYCGN-UHFFFAOYSA-N;   SMILES=NC(Cc1c[nH]c2ccc(O)cc12)C(O)=O
 alt_id: CHEBI:20595;   CHEBI:2081
 xref: CAS:114-03-4;   CAS:56-69-9;   KEGG:C01017;   KNApSAcK:C00001371
 xref_mesh: MESH:D006916
 xref: PMID:14563478;   PMID:15617538;   Reaxys:88199;   Wikipedia:5-Hydroxytryptophan


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5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein decreases expression ISO 5-Hydroxytryptophan results in decreased expression of AFP mRNA CTD PMID:32926198 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649 		JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of GATA4 mRNA CTD PMID:32926198 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO 5-Hydroxytryptophan results in decreased expression of NANOG mRNA CTD PMID:32926198 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA CTD PMID:32926198 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:106,085,953...106,312,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      biological role 20829
        molecular messenger 19450
          neurotransmitter 11783
            5-hydroxytryptophan 6
              5-hydroxy-D-tryptophan 0
              5-hydroxy-L-tryptophan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    main group molecular entity 20794
                      s-block molecular entity 20589
                        hydrogen molecular entity 20573
                          hydrides 19703
                            inorganic hydride 18601
                              pnictogen hydride 18588
                                nitrogen hydride 18501
                                  azane 18260
                                    ammonia 18259
                                      organic amino compound 18259
                                        amino acid 16334
                                          alpha-amino acid 14248
                                            non-proteinogenic alpha-amino acid 3850
                                              hydroxy-amino acid 7
                                                hydroxytryptophan 6
                                                  5-hydroxytryptophan 6
                                                    5-hydroxy-D-tryptophan 0
                                                    5-hydroxy-L-tryptophan 0
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