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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-hydroxytryptophan
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Accession:CHEBI:28171 term browser browse the term
Definition:A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Synonyms:exact_synonym: 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
 related_synonym: 5-HTP;   5-hydroxy-DL-tryptophan;   5-hydroxytryptophan DL-form;   DL-5-HTP;   DL-5-hydroxytryptophan;   Formula=C11H12N2O3;   InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16);   InChIKey=LDCYZAJDBXYCGN-UHFFFAOYSA-N;   SMILES=NC(Cc1c[nH]c2ccc(O)cc12)C(O)=O
 alt_id: CHEBI:20595;   CHEBI:2081
 xref: Beilstein:88199;   CAS:114-03-4;   CAS:56-69-9;   KEGG:C01017;   KNApSAcK:C00001371
 xref_mesh: MESH:D006916
 xref: PMID:14563478;   PMID:15617538;   Reaxys:88199;   Wikipedia:5-Hydroxytryptophan


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5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein decreases expression ISO 5-Hydroxytryptophan results in decreased expression of AFP mRNA CTD PMID:32926198 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of GATA4 mRNA CTD PMID:32926198 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO 5-Hydroxytryptophan results in decreased expression of NANOG mRNA CTD PMID:32926198 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA CTD PMID:32926198 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        molecular messenger 18704
          neurotransmitter 11684
            5-hydroxytryptophan 6
              5-hydroxy-D-tryptophan 0
              5-hydroxy-L-tryptophan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    main group molecular entity 19838
                      s-block molecular entity 19698
                        hydrogen molecular entity 19679
                          hydrides 19181
                            inorganic hydride 18192
                              pnictogen hydride 18157
                                nitrogen hydride 18070
                                  azane 17873
                                    ammonia 17898
                                      organic amino compound 17898
                                        amino acid 16074
                                          alpha-amino acid 13947
                                            non-proteinogenic alpha-amino acid 3798
                                              hydroxy-amino acid 7
                                                hydroxytryptophan 6
                                                  5-hydroxytryptophan 6
                                                    5-hydroxy-D-tryptophan 0
                                                    5-hydroxy-L-tryptophan 0
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