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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloral hydrate
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Accession:CHEBI:28142 term browser browse the term
Definition:An organochlorine compound that is the hydrate of trichloroacetaldehyde.
Synonyms:exact_synonym: 2,2,2-trichloroethane-1,1-diol
 related_synonym: 1,1,1-trichloro-2,2-dihydroxyethane;   1,1,1-trichloro-2,2-ethanediol;   2,2,2-trichloro-1,1-ethanediol;   Aquachloral Supprettes;   Chloralhydrat;   Formula=C2H3Cl3O2;   InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H;   InChIKey=RNFNDJAIBTYOQL-UHFFFAOYSA-N;   Noctec;   SMILES=OC(O)C(Cl)(Cl)Cl;   Somnote;   Trichloracetaldehyd-hydrat;   chloral monohydrate;   knockout drops;   trichloroacetaldehyde hydrate
 alt_id: CHEBI:23105;   CHEBI:3600
 xref: Beilstein:1698497;   CAS:302-17-0;   DrugBank:DB01563;   Drug_Central:586;   Gmelin:101369;   KEGG:C06899;   KEGG:D00265
 xref_mesh: MESH:D002697
 xref: MetaCyc:CPD0-1476;   PPDB:2987;   UM-BBD_compID:c0011;   VSDB:2987


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chloral hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO
EXP		 [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde		 CTD PMID:18272654 PMID:21334317 PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:7513451 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA] CTD PMID:7513451 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis
multiple interactions		 EXP CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate
[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate		 CTD PMID:1739413 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:15219685 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gast gastrin multiple interactions EXP Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
increases expression		 EXP Chloral Hydrate results in decreased expression of GJA1 mRNA; Chloral Hydrate results in decreased expression of GJA1 protein
Chloral Hydrate results in increased expression of GJA1 protein		 CTD PMID:21243523 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression
increases expression		 EXP Chloral Hydrate results in decreased expression of GJB2 mRNA
Chloral Hydrate results in increased expression of GJB2 protein		 CTD PMID:21243523 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Chloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Chloral Hydrate affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Chloral Hydrate results in increased expression of IL1B mRNA
Ozone inhibits the reaction [Chloral Hydrate results in increased expression of IL1B mRNA]		 CTD PMID:15207037 PMID:15207038 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression EXP Chloral Hydrate results in increased expression of IL6 mRNA CTD PMID:15207037 PMID:15207038 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        xenobiotic 18732
          chloral hydrate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      chalcogen 19598
                        oxygen atom 19570
                          oxygen molecular entity 19570
                            hydroxides 19374
                              organic hydroxy compound 18978
                                polyol 11687
                                  diol 3951
                                    ethanediol 165
                                      chloral hydrate 16
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