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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,4'-methylene-bis-(2-chloroaniline)
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Accession:CHEBI:28124 term browser browse the term
Definition:A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.
Synonyms:exact_synonym: 4,4'-methanediylbis(2-chloroaniline)
 related_synonym: Formula=C13H12Cl2N2;   InChI=1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2;   InChIKey=IBOFVQJTBBUKMU-UHFFFAOYSA-N;   MOCA;   Methylenebis(chloroaniline);   SMILES=Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
 alt_id: CHEBI:1741;   CHEBI:20264
 xref: CAS:101-14-4;   KEGG:C10999
 xref_mesh: MESH:D008753
 xref: PMID:19447850;   PMID:21501672;   Reaxys:1882318;   Wikipedia:4\,4'-Methylenebis(2-chloroaniline)



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4,4'-methylene-bis-(2-chloroaniline) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylenebis(chloroaniline) results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847
JBrowse link
G Alb albumin affects binding EXP Methylenebis(chloroaniline) binds to ALB protein CTD PMID:2019352 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of Methylenebis(chloroaniline) CTD PMID:2908851 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation
multiple interactions
ISO CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)
alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
CTD PMID:1740010 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Methylenebis(chloroaniline) results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:9,018,762...9,072,552 JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Methylenebis(chloroaniline) results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053
JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of Methylenebis(chloroaniline) CTD PMID:9288889 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects binding
ISO NAT2 protein results in increased acetylation of Methylenebis(chloroaniline); NAT2 protein results in increased acetylation of Methylenebis(chloroaniline) analog
Methylenebis(chloroaniline) binds to NAT2 protein
CTD PMID:29180287 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        biochemical role 20268
          metabolite 20237
            4,4'-methylene-bis-(2-chloroaniline) 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20565
                        hydrogen molecular entity 20549
                          hydrides 19684
                            inorganic hydride 18588
                              pnictogen hydride 18592
                                nitrogen hydride 18506
                                  azane 18249
                                    ammonia 18263
                                      organic amino compound 18263
                                        aromatic amine 15810
                                          anilines 14551
                                            substituted aniline 14205
                                              chloroaniline 234
                                                4,4'-methylene-bis-(2-chloroaniline) 15
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