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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diethanolamine
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Accession:CHEBI:28123 term browser browse the term
Definition:A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.
Synonyms:related_synonym: 2,2'-Iminodiethanol;   Formula=C4H11NO2;   H2dea;   InChI=1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2;   InChIKey=ZBCBWPMODOFKDW-UHFFFAOYSA-N;   N,N-di(hydroxyethyl)amine;   SMILES=OCCNCCO;   bis-(2-hydroxy-ethyl)-amine;   diolamine
 alt_id: CHEBI:23706;   CHEBI:4519
 xref: CAS:111-42-2;   HMDB:HMDB0004437;   KEGG:C06772;   KEGG:D02337;   LINCS:LSM-26236
 xref_mesh: MESH:C020283
 xref: PMID:12571685;   PMID:15304302;   PMID:23567043;   PMID:24275050;   Reaxys:605315;   UM-BBD_compID:c0589;   Wikipedia:Diethanolamine


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diethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death decreases expression ISO
EXP		 diethanolamine results in decreased expression of BAD mRNA CTD PMID:16014740 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP
ISO		 diethanolamine results in decreased expression of BAX mRNA CTD PMID:16014740 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Calb1 calbindin 1 increases expression ISO diethanolamine results in increased expression of CALB1 mRNA CTD PMID:35812078 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Casp3 caspase 3 decreases expression
increases activity		 ISO
EXP		 diethanolamine results in decreased expression of CASP3 mRNA
diethanolamine results in increased activity of CASP3 protein		 CTD PMID:16014740 PMID:18948303 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd2 cyclin D2 increases expression ISO
EXP		 diethanolamine results in increased expression of CCND2 mRNA CTD PMID:16014740 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO
EXP		 diethanolamine results in increased expression of CCNE1 mRNA CTD PMID:16014740 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO
EXP		 diethanolamine results in decreased expression of CDKN1A mRNA CTD PMID:16014740 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO
EXP		 diethanolamine results in decreased expression of CDKN1B mRNA CTD PMID:16014740 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO
EXP		 diethanolamine results in increased expression of E2F1 mRNA CTD PMID:16014740 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [diethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO diethanolamine results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO
EXP		 diethanolamine results in decreased expression of TRP53 mRNA
diethanolamine results in decreased expression of TP53 mRNA		 CTD PMID:16014740 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt1 Wnt family member 1 increases expression ISO diethanolamine results in increased expression of WNT1 mRNA CTD PMID:35812078 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            xenobiotic metabolite 16158
              human xenobiotic metabolite 15778
                diethanolamine 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino alcohol 1075
                                          ethanolamines 826
                                            ethanolamine 92
                                              diethanolamine 13
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