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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2,2-trichloroethanol
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Accession:CHEBI:28094 term browser browse the term
Definition:A chloroethanol that has formula C2H3Cl3O.
Synonyms:related_synonym: 2,2,2-trichloro-1-ethanol;   Formula=C2H3Cl3O;   InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2;   InChIKey=KPWDGTGXUYRARH-UHFFFAOYSA-N;   SMILES=OCC(Cl)(Cl)Cl;   Trichloroethanol
 alt_id: CHEBI:27098;   CHEBI:9685
 xref: Beilstein:1697495;   CAS:115-20-8;   Gmelin:2407;   KEGG:C07490
 xref_mesh: MESH:C005849
 xref: UM-BBD_compID:c0015


show annotations for term's descendants           Sort by:
2,2,2-trichloroethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding ISO 2,2,2-trichloroethanol binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 2,2,2-trichloroethanol results in increased expression of IL1A protein CTD PMID:23041168 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein] CTD PMID:36423715 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		ISO 2,2,2-trichloroethanol results in increased expression of IL6 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [2,2,2-trichloroethanol results in increased expression of IL6 protein] 		CTD PMID:23041168 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity 		ISO 2,2,2-trichloroethanol results in increased expression of MMP9 mRNA; 2,2,2-trichloroethanol results in increased expression of MMP9 protein
2,2,2-trichloroethanol results in increased activity of MMP9 protein 		CTD PMID:21741468 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of MYD88 protein CTD PMID:36423715 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in decreased expression of NFKBIA protein CTD PMID:36423715 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein] CTD PMID:36423715 NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein] CTD PMID:36423715 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein] CTD PMID:36423715 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein] CTD PMID:36423715 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 2,2,2-trichloroethanol results in increased expression of TIMP1 mRNA; 2,2,2-trichloroethanol results in increased expression of TIMP1 protein CTD PMID:21741468 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR2 protein CTD PMID:36423715 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR4 protein CTD PMID:36423715 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein] CTD PMID:36423715 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      molecular entity 20859
        polyatomic entity 20803
          heteroatomic molecular entity 20740
            halide 19179
              organohalogen compound 18997
                organochlorine compound 18749
                  chloroethanol 44
                    2,2,2-trichloroethanol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      chalcogen 20491
                        oxygen atom 20457
                          oxygen molecular entity 20457
                            hydroxides 20230
                              organic hydroxy compound 19765
                                alcohol 16148
                                  primary alcohol 15242
                                    ethanols 10015
                                      chloroethanol 44
                                        2,2,2-trichloroethanol 15
paths to the root