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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,2,2-trichloroethanol
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Accession:CHEBI:28094 term browser browse the term
Definition:A chloroethanol that has formula C2H3Cl3O.
Synonyms:related_synonym: 2,2,2-trichloro-1-ethanol;   Formula=C2H3Cl3O;   InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2;   InChIKey=KPWDGTGXUYRARH-UHFFFAOYSA-N;   SMILES=OCC(Cl)(Cl)Cl;   Trichloroethanol
 alt_id: CHEBI:27098;   CHEBI:9685
 xref: Beilstein:1697495;   CAS:115-20-8;   Gmelin:2407;   KEGG:C07490
 xref_mesh: MESH:C005849
 xref: UM-BBD_compID:c0015



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2,2,2-trichloroethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding ISO 2,2,2-trichloroethanol binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 2,2,2-trichloroethanol results in increased expression of IL1A protein CTD PMID:23041168 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein] CTD PMID:36423715 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 2,2,2-trichloroethanol results in increased expression of IL6 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [2,2,2-trichloroethanol results in increased expression of IL6 protein]
CTD PMID:23041168 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity
ISO 2,2,2-trichloroethanol results in increased expression of MMP9 mRNA; 2,2,2-trichloroethanol results in increased expression of MMP9 protein
2,2,2-trichloroethanol results in increased activity of MMP9 protein
CTD PMID:21741468 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of MYD88 protein CTD PMID:36423715 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in decreased expression of NFKBIA protein CTD PMID:36423715 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein] CTD PMID:36423715 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein] CTD PMID:36423715 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein] CTD PMID:36423715 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein] CTD PMID:36423715 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 2,2,2-trichloroethanol results in increased expression of TIMP1 mRNA; 2,2,2-trichloroethanol results in increased expression of TIMP1 protein CTD PMID:21741468 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR2 protein CTD PMID:36423715 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR4 protein CTD PMID:36423715 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein] CTD PMID:36423715 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      molecular entity 19880
        polyatomic entity 19862
          heteroatomic molecular entity 19818
            halide 18694
              organohalogen compound 18558
                organochlorine compound 18331
                  chloroethanol 44
                    2,2,2-trichloroethanol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      chalcogen 19598
                        oxygen atom 19570
                          oxygen molecular entity 19570
                            hydroxides 19374
                              organic hydroxy compound 18978
                                alcohol 15737
                                  primary alcohol 14684
                                    ethanols 8830
                                      chloroethanol 44
                                        2,2,2-trichloroethanol 15
paths to the root