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G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions |
ISO |
crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] |
CTD |
PMID:30580027 |
|
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:32633567 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
ISO |
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] |
CTD |
PMID:30580027 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Atg5 |
autophagy related 5 |
multiple interactions |
EXP |
crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]] |
CTD |
PMID:33021114 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bambi |
BMP and activin membrane-bound inhibitor |
multiple interactions |
EXP |
crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA] |
CTD |
PMID:32259551 |
|
NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein] crocin results in increased expression of BAX mRNA crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein] |
CTD |
PMID:23523949 PMID:26231423 PMID:27353299 PMID:32886819 PMID:32920515 PMID:35274200 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO EXP |
[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA; crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein] crocin results in decreased expression of BCL2 mRNA crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein] |
CTD |
PMID:26231423 PMID:31911963 PMID:32886819 PMID:32920515 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
increases expression |
EXP |
crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein |
CTD |
PMID:24401376 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Becn1 |
beclin 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]; crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of BECN1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]] |
CTD |
PMID:33021114 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
crocin results in decreased expression of BIRC5 mRNA |
CTD |
PMID:32886819 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage increases expression increases activity |
EXP ISO |
crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein] crocin results in increased cleavage of CASP3 protein Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein] crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA] crocin results in increased expression of CASP3 mRNA |
CTD |
PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 PMID:30672053 PMID:31911963 PMID:32886819 PMID:32920515 PMID:35085590 PMID:35274200 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
crocin results in increased activity of CASP8 protein |
CTD |
PMID:32886819 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
EXP ISO |
crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein] crocin results in increased activity of CASP9 protein |
CTD |
PMID:27353299 PMID:32886819 PMID:35274200 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases activity decreases activity |
EXP ISO |
crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] crocin results in increased activity of CAT protein crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein] crocin results in decreased activity of CAT protein |
CTD |
PMID:25899501 PMID:26231423 PMID:26584762 PMID:29409856 PMID:32886819 PMID:32920515 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
crocin results in decreased expression of CCND1 mRNA |
CTD |
PMID:32886819 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
crocin inhibits the reaction [Diazinon results in increased activity of CKM protein] |
CTD |
PMID:23523949 |
|
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] |
CTD |
PMID:24709313 |
|
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
crocin results in increased expression of and results in increased phosphorylation of CREB1 protein |
CTD |
PMID:24401376 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
crocin inhibits the reaction [Diazinon affects the localization of CYCS protein] |
CTD |
PMID:23523949 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions decreases activity |
EXP |
crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein] crocin results in decreased activity of CYP2E1 protein |
CTD |
PMID:25899501 PMID:32633567 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Foxp2 |
forkhead box P2 |
increases expression |
ISO |
crocin results in increased expression of FOXP2 protein |
CTD |
PMID:36988377 |
|
NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
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G |
Glo1 |
glyoxalase 1 |
multiple interactions |
ISO |
crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] |
CTD |
PMID:30580027 |
|
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein] crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein] |
CTD |
PMID:26231423 PMID:32259551 PMID:32633567 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein] |
CTD |
PMID:32920515 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
multiple interactions |
EXP |
crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] |
CTD |
PMID:25637687 |
|
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein] |
CTD |
PMID:26807765 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] |
CTD |
PMID:24709313 PMID:26807765 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
EXP ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] crocin results in decreased expression of IL6 mRNA |
CTD |
PMID:25637687 PMID:25899501 PMID:29409856 PMID:32633567 PMID:32886819 PMID:32920515 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] |
CTD |
PMID:29409856 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
crocin affects the expression of and affects the phosphorylation of JAK2 protein |
CTD |
PMID:32886819 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] |
CTD |
PMID:32920515 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
EXP |
crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA] |
CTD |
PMID:24132704 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
[Quercetin co-treated with crocin] inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]] |
CTD |
PMID:33021114 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
EXP ISO |
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein] crocin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:24132704 PMID:28689058 PMID:32886819 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
EXP ISO |
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein] crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA] crocin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mir122 |
microRNA 122 |
multiple interactions decreases expression |
EXP ISO |
crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA] crocin results in decreased expression of MIR122 |
CTD |
PMID:28689058 PMID:36988377 |
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NCBI chr18:58,758,703...58,758,787
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G |
Mir29b1 |
microRNA 29b-1 |
increases expression multiple interactions |
EXP |
crocin results in increased expression of MIR29B1 mRNA Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA] |
CTD |
PMID:32259551 |
|
NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
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G |
Mir34a |
microRNA 34a |
multiple interactions |
ISO |
MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein] |
CTD |
PMID:35085590 |
|
NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
crocin inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:25637687 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
crocin results in decreased expression of MYC mRNA |
CTD |
PMID:32886819 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Mycn |
MYCN proto-oncogene, bHLH transcription factor |
decreases response to substance decreases expression multiple interactions |
ISO |
MYCN results in decreased susceptibility to crocin crocin results in decreased expression of MYCN protein crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein] |
CTD |
PMID:30672053 |
|
NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein] |
CTD |
PMID:32259551 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein] |
CTD |
PMID:32259551 PMID:32920515 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein] |
CTD |
PMID:32920515 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Ostm1 |
osteoclastogenesis associated transmembrane protein 1 |
multiple interactions |
ISO |
[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] |
CTD |
PMID:30580027 |
|
NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein] |
CTD |
PMID:30672053 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein] |
CTD |
PMID:32633567 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkab1 |
protein kinase AMP-activated non-catalytic subunit beta 1 |
multiple interactions |
EXP |
crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]] |
CTD |
PMID:33021114 |
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NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
crocin results in decreased expression of PTGS2 mRNA |
CTD |
PMID:32886819 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn4 |
protein tyrosine phosphatase, non-receptor type 4 |
multiple interactions increases expression |
ISO |
MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein] |
CTD |
PMID:35085590 |
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NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein] |
CTD |
PMID:29409856 PMID:32920515 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Smad2 |
SMAD family member 2 |
decreases expression multiple interactions |
EXP |
crocin results in decreased expression of SMAD2 protein Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein] |
CTD |
PMID:32259551 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Snca |
synuclein alpha |
multiple interactions |
EXP |
crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein] |
CTD |
PMID:35274200 |
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NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Spry2 |
sprouty RTK signaling antagonist 2 |
increases expression |
ISO |
crocin results in increased expression of SPRY2 protein |
CTD |
PMID:36988377 |
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NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]] |
CTD |
PMID:33021114 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
crocin affects the expression of and affects the phosphorylation of STAT3 protein |
CTD |
PMID:32886819 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]] |
CTD |
PMID:29409856 PMID:32259551 PMID:32633567 PMID:33021114 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein] |
CTD |
PMID:32259551 |
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NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] |
CTD |
PMID:29409856 PMID:32259551 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
EXP ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein] crocin results in decreased expression of TNF mRNA |
CTD |
PMID:25637687 PMID:25899501 PMID:26807765 PMID:32633567 PMID:32886819 PMID:32920515 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] |
CTD |
PMID:30580027 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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G |
Tnnt2 |
troponin T2, cardiac type |
multiple interactions |
EXP |
crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein] |
CTD |
PMID:26807765 |
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NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein] |
CTD |
PMID:26231423 PMID:31911963 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] |
CTD |
PMID:30580027 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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G |
Vgf |
VGF nerve growth factor inducible |
increases expression |
EXP |
crocin results in increased expression of VGF protein |
CTD |
PMID:24401376 |
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NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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