|
G
|
Ache
|
acetylcholinesterase
|
increases activity multiple interactions
|
ISO
|
Galactose results in increased activity of ACHE protein catalpol inhibits the reaction [Galactose results in increased activity of ACHE protein]; theaflavin-3,3'-digallate inhibits the reaction [Galactose results in increased activity of ACHE protein]
|
CTD |
PMID:23612000 PMID:36638877 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
Ager
|
advanced glycosylation end product-specific receptor
|
increases expression decreases expression multiple interactions
|
ISO EXP
|
Galactose results in increased expression of AGER mRNA; Galactose results in increased expression of AGER protein Galactose results in decreased expression of AGER protein [Ethanol co-treated with Galactose] results in decreased expression of AGER protein agomelatine inhibits the reaction [Galactose results in increased expression of AGER protein]
|
CTD |
PMID:22687555 PMID:33516661 PMID:34673010 |
|
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
|
|
G
|
Aif1
|
allograft inflammatory factor 1
|
increases expression multiple interactions
|
ISO EXP
|
Galactose results in increased expression of AIF1 protein lycopene inhibits the reaction [Galactose results in increased expression of AIF1 protein] agomelatine inhibits the reaction [Galactose results in increased expression of AIF1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of AIF1 protein]
|
CTD |
PMID:28974442 PMID:34673010 |
|
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
|
|
G
|
Akr1b1
|
aldo-keto reductase family 1 member B1
|
multiple interactions increases expression
|
ISO
|
protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA]
|
CTD |
PMID:22687555 |
|
NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315
|
|
G
|
Aox1
|
aldehyde oxidase 1
|
increases expression multiple interactions
|
ISO
|
Galactose results in increased expression of AOX1 mRNA sodium bisulfide inhibits the reaction [Galactose results in increased expression of AOX1 mRNA]
|
CTD |
PMID:23274001 |
|
NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
ISO
|
[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein]
|
CTD |
PMID:35537655 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
|
G
|
Aqp4
|
aquaporin 4
|
multiple interactions
|
ISO
|
[Ethanol co-treated with Galactose] results in decreased expression of AQP4 protein
|
CTD |
PMID:33516661 |
|
NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
|
|
G
|
Atf4
|
activating transcription factor 4
|
multiple interactions
|
ISO
|
[Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of ATF4 protein]
|
CTD |
PMID:29427785 |
|
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
|
|
G
|
Atg5
|
autophagy related 5
|
decreases expression multiple interactions
|
EXP
|
Galactose results in decreased expression of ATG5 mRNA candesartan inhibits the reaction [Galactose results in decreased expression of ATG5 mRNA]
|
CTD |
PMID:34906534 |
|
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
|
|
G
|
Atg7
|
autophagy related 7
|
decreases expression multiple interactions
|
EXP ISO
|
Galactose results in decreased expression of ATG7 protein MIR34A mRNA promotes the reaction [Galactose results in decreased expression of ATG7 protein]
|
CTD |
PMID:28302704 |
|
NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319
|
|
G
|
Atox1
|
antioxidant 1 copper chaperone
|
decreases expression multiple interactions
|
ISO
|
Galactose results in decreased expression of ATOX1 mRNA sodium bisulfide inhibits the reaction [Galactose results in decreased expression of ATOX1 mRNA]
|
CTD |
PMID:23274001 |
|
NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585
|
|
G
|
Atp5f1a
|
ATP synthase F1 subunit alpha
|
multiple interactions
|
EXP
|
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of ATP5F1A protein
|
CTD |
PMID:25997894 |
|
NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases expression
|
ISO EXP
|
Phycocyanin inhibits the reaction [Galactose results in increased expression of BAX protein] Galactose results in increased expression of BAX mRNA; Galactose results in increased expression of BAX protein agomelatine inhibits the reaction [Galactose results in increased expression of BAX protein]; Finasteride inhibits the reaction [Galactose results in increased expression of BAX protein]; Galactose promotes the reaction [sodium arsenite results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Galactose results in increased expression of BAX protein]; Saponins inhibits the reaction [Galactose results in increased expression of BAX protein] torularhodin inhibits the reaction [Galactose results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Galactose results in increased expression of BAX protein]
|
CTD |
PMID:23036742 PMID:25892055 PMID:31431007 PMID:34673010 PMID:35259467 PMID:39265715 More...
|
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions decreases expression
|
ISO EXP
|
Phycocyanin inhibits the reaction [Galactose results in decreased expression of BCL2 protein] agomelatine inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Galactose promotes the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Saponins inhibits the reaction [Galactose results in decreased expression of BCL2 protein] Galactose results in decreased expression of BCL2 mRNA; Galactose results in decreased expression of BCL2 protein
|
CTD |
PMID:23036742 PMID:25892055 PMID:34673010 PMID:35259467 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
decreases expression multiple interactions
|
ISO
|
Galactose results in decreased expression of BDNF mRNA; Galactose results in decreased expression of BDNF protein lycopene inhibits the reaction [Galactose results in decreased expression of BDNF mRNA]; lycopene inhibits the reaction [Galactose results in decreased expression of BDNF protein]
|
CTD |
PMID:28974442 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
G
|
Becn1
|
beclin 1
|
multiple interactions decreases expression
|
EXP
|
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]; candesartan inhibits the reaction [Galactose results in decreased expression of BECN1 mRNA] Galactose results in decreased expression of BECN1 mRNA; Galactose results in decreased expression of BECN1 protein
|
CTD |
PMID:25997894 PMID:28302704 PMID:34906534 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
|
|
G
|
Casp12
|
caspase 12
|
multiple interactions increases expression
|
EXP
|
agomelatine inhibits the reaction [Galactose results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP12 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
|
|
G
|
Casp3
|
caspase 3
|
increases cleavage multiple interactions increases activity increases expression
|
ISO EXP
|
Galactose results in increased cleavage of CASP3 protein Phycocyanin inhibits the reaction [Galactose results in increased cleavage of CASP3 protein] Galactose results in increased activity of CASP3 protein albicanol inhibits the reaction [Galactose results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Galactose results in increased activity of CASP3 protein] [Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP3 protein]
|
CTD |
PMID:23036742 PMID:23795773 PMID:25997894 PMID:32295448 PMID:33761044 PMID:34673010 More...
|
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions increases expression
|
EXP ISO
|
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein] Galactose results in increased expression of CASP9 protein albicanol inhibits the reaction [Galactose results in increased expression of CASP9 mRNA]
|
CTD |
PMID:25997894 PMID:32295448 PMID:33761044 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
increases activity multiple interactions decreases activity affects activity
|
EXP ISO
|
Galactose results in increased activity of CAT protein [Galactose co-treated with Finasteride] results in increased expression of CAT mRNA; candesartan inhibits the reaction [Galactose results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Galactose results in increased activity of CAT protein] [Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein; albicanol inhibits the reaction [Galactose results in decreased activity of CAT protein]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein]; torularhodin inhibits the reaction [Galactose results in decreased activity of CAT protein] Galactose affects the activity of CAT protein
|
CTD |
PMID:17211565 PMID:31431007 PMID:32295448 PMID:33761044 PMID:34906534 PMID:35537655 PMID:39265715 More...
|
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccn1
|
cellular communication network factor 1
|
multiple interactions
|
ISO
|
[Galactose co-treated with Fenofibrate] results in increased expression of CCN1 protein
|
CTD |
PMID:39442682 |
|
NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
|
|
G
|
Ccn2
|
cellular communication network factor 2
|
increases expression multiple interactions
|
EXP
|
Galactose results in increased expression of CCN2 protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of CCN2 protein]
|
CTD |
PMID:30367734 |
|
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
|
|
G
|
Cdh5
|
cadherin 5
|
multiple interactions decreases expression
|
ISO
|
Ethanol promotes the reaction [Galactose results in decreased expression of CDH5 protein]
|
CTD |
PMID:33516661 |
|
NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822
|
|
G
|
Cdk5r1
|
cyclin-dependent kinase 5 regulatory subunit 1
|
increases expression multiple interactions
|
ISO
|
Galactose results in increased expression of CDK5R1 protein gentiopicroside analog inhibits the reaction [Galactose results in increased expression of CDK5R1 protein]
|
CTD |
PMID:36878094 |
|
NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272
|
|
G
|
Cdkn2a
|
cyclin-dependent kinase inhibitor 2A
|
multiple interactions increases expression
|
EXP ISO
|
agomelatine inhibits the reaction [Galactose results in increased expression of CDKN2A protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]]
|
CTD |
PMID:34673010 PMID:36792013 |
|
NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248
|
|
G
|
Chat
|
choline O-acetyltransferase
|
multiple interactions decreases activity
|
ISO
|
catalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein]
|
CTD |
PMID:23612000 |
|
NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416
|
|
G
|
Chrm1
|
cholinergic receptor, muscarinic 1
|
multiple interactions decreases expression
|
ISO
|
catalpol inhibits the reaction [Galactose results in decreased expression of CHRM1 protein]
|
CTD |
PMID:23612000 |
|
NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602
|
|
G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions decreases expression
|
ISO
|
gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of CTNNB1 protein]
|
CTD |
PMID:36878094 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
|
|
G
|
Cybb
|
cytochrome b-245 beta chain
|
increases expression multiple interactions
|
EXP
|
Galactose results in increased expression of CYBB protein agomelatine inhibits the reaction [Galactose results in increased expression of CYBB protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CYBB protein]
|
CTD |
PMID:34673010 |
|
NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
multiple interactions increases expression
|
ISO EXP
|
[Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of DDIT3 protein]; Phycocyanin inhibits the reaction [Galactose results in increased expression of DDIT3 protein] agomelatine inhibits the reaction [Galactose results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of DDIT3 protein]
|
CTD |
PMID:23036742 PMID:29427785 PMID:34673010 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
|
|
G
|
Dnm1l
|
dynamin 1-like
|
increases expression multiple interactions
|
ISO EXP
|
Galactose results in increased expression of DNM1L protein MIR34A mRNA promotes the reaction [Galactose results in increased expression of DNM1L protein]
|
CTD |
PMID:28302704 |
|
NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420
|
|
G
|
Eif2ak3
|
eukaryotic translation initiation factor 2 alpha kinase 3
|
multiple interactions increases phosphorylation
|
EXP
|
agomelatine inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein]; Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
|
|
G
|
Ern1
|
endoplasmic reticulum to nucleus signaling 1
|
increases phosphorylation multiple interactions
|
EXP
|
Galactose results in increased phosphorylation of ERN1 protein agomelatine inhibits the reaction [Galactose results in increased phosphorylation of ERN1 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
|
|
G
|
Fgf2
|
fibroblast growth factor 2
|
multiple interactions increases expression
|
EXP
|
Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of FGF2 protein]
|
CTD |
PMID:30367734 |
|
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
|
|
G
|
Galk1
|
galactokinase 1
|
multiple interactions increases metabolic processing
|
ISO
|
[GALK1 protein results in increased metabolism of Galactose] which results in increased abundance of galactose-1-phosphate
|
CTD |
PMID:20696150 |
|
NCBI chr10:101,742,067...101,746,244
Ensembl chr10:101,735,061...101,746,258
|
|
G
|
Gap43
|
growth associated protein 43
|
decreases expression multiple interactions
|
ISO
|
Galactose results in decreased expression of GAP43 mRNA Quercetin inhibits the reaction [Galactose results in decreased expression of GAP43 mRNA]
|
CTD |
PMID:16707173 |
|
NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
decreases expression multiple interactions
|
EXP
|
Galactose results in decreased expression of GCLC mRNA Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA]
|
CTD |
PMID:25892055 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
G
|
Gdnf
|
glial cell derived neurotrophic factor
|
multiple interactions decreases expression
|
EXP
|
candesartan inhibits the reaction [Galactose results in decreased expression of GDNF mRNA]
|
CTD |
PMID:34906534 |
|
NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions increases expression
|
EXP
|
agomelatine inhibits the reaction [Galactose results in increased expression of GFAP protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GFAP protein]
|
CTD |
PMID:34673010 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
|
|
G
|
Glb1
|
galactosidase, beta 1
|
increases expression multiple interactions
|
ISO
|
Galactose results in increased expression of GLB1 protein (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]]
|
CTD |
PMID:36792013 |
|
NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326
|
|
G
|
Glo1
|
glyoxalase 1
|
multiple interactions
|
ISO
|
Galactose results in decreased expression of and results in decreased activity of GLO1 protein; protocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein]
|
CTD |
PMID:22687555 |
|
NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein]
|
CTD |
PMID:34416243 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
multiple interactions decreases expression
|
ISO
|
theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of GPX1 mRNA]
|
CTD |
PMID:36638877 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
|
|
G
|
Gpx4
|
glutathione peroxidase 4
|
multiple interactions
|
EXP
|
[Galactose co-treated with Finasteride] results in increased expression of GPX4 protein
|
CTD |
PMID:39265715 |
|
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
|
|
G
|
Grin1
|
glutamate ionotropic receptor NMDA type subunit 1
|
increases expression multiple interactions
|
EXP
|
Galactose results in increased expression of GRIN1 protein agomelatine inhibits the reaction [Galactose results in increased expression of GRIN1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GRIN1 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754
|
|
G
|
Grin2b
|
glutamate ionotropic receptor NMDA type subunit 2B
|
increases expression multiple interactions
|
EXP
|
Galactose results in increased expression of GRIN2B protein agomelatine inhibits the reaction [Galactose results in increased expression of GRIN2B protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GRIN2B protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions
|
ISO
|
Galactose results in increased expression of and results in decreased phosphorylation of GSK3B protein; gentiopicroside analog inhibits the reaction [Galactose results in increased expression of and results in decreased phosphorylation of GSK3B protein]
|
CTD |
PMID:36878094 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
Gss
|
glutathione synthetase
|
multiple interactions decreases expression
|
ISO
|
sodium bisulfide inhibits the reaction [Galactose results in decreased expression of GSS mRNA]
|
CTD |
PMID:23274001 |
|
NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306
|
|
G
|
Hes1
|
hes family bHLH transcription factor 1
|
multiple interactions
|
ISO
|
[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein]
|
CTD |
PMID:35537655 |
|
NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
Galactose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]
|
CTD |
PMID:31654802 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
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G
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Hmox1
|
heme oxygenase 1
|
multiple interactions decreases expression
|
EXP ISO
|
Saponins inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA] albicanol inhibits the reaction [Galactose results in decreased expression of HMOX1 protein]; Lycopene inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA]; torularhodin inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA]; torularhodin inhibits the reaction [Galactose results in decreased expression of HMOX1 protein]; Vitamin E inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA]; Vitamin E inhibits the reaction [Galactose results in decreased expression of HMOX1 protein] Galactose results in decreased expression of HMOX1 mRNA; Galactose results in decreased expression of HMOX1 protein
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CTD |
PMID:25892055 PMID:28974442 PMID:31431007 PMID:33761044 |
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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G
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Hsf1
|
heat shock transcription factor 1
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increases activity
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ISO
|
Galactose results in increased activity of HSF1 protein
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CTD |
PMID:34170685 |
|
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
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G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
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multiple interactions increases expression
|
ISO EXP
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Phycocyanin inhibits the reaction [Galactose results in increased expression of HSPA5 protein] Melatonin inhibits the reaction [Galactose results in increased expression of HSPA5 protein]
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CTD |
PMID:23036742 PMID:34673010 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
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G
|
Ifnb1
|
interferon beta 1
|
multiple interactions
|
ISO
|
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein; scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein]
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CTD |
PMID:23535186 |
|
NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487
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G
|
Il10
|
interleukin 10
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multiple interactions
|
ISO
|
[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein]
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CTD |
PMID:35537655 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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G
|
Il1b
|
interleukin 1 beta
|
increases expression increases secretion multiple interactions
|
ISO EXP
|
Galactose results in increased expression of IL1B mRNA; Galactose results in increased expression of IL1B protein Galactose results in increased secretion of IL1B protein [Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein; albicanol inhibits the reaction [Galactose results in increased expression of IL1B mRNA]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; catalpol inhibits the reaction [Galactose results in increased expression of IL1B protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; Lycopene inhibits the reaction [Galactose results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL1B protein]; torularhodin inhibits the reaction [Galactose results in increased secretion of IL1B protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]
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CTD |
PMID:22687555 PMID:23612000 PMID:28974442 PMID:29405769 PMID:31431007 PMID:32295448 PMID:33761044 PMID:35537655 More...
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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G
|
Il6
|
interleukin 6
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multiple interactions increases secretion increases expression
|
ISO EXP
|
[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein; [Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL6 protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein]; torularhodin inhibits the reaction [Galactose results in increased secretion of IL6 protein] 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside compound K inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] Galactose results in increased expression of IL6 mRNA; Galactose results in increased expression of IL6 protein Galactose promotes the reaction [sodium arsenite results in increased expression of IL6 mRNA]
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CTD |
PMID:22687555 PMID:23535186 PMID:29412148 PMID:31431007 PMID:32295448 PMID:34416243 PMID:35259467 PMID:35537655 More...
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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G
|
Ins1
|
insulin 1
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increases expression
|
EXP
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Galactose results in increased expression of INS1 protein
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CTD |
PMID:39265715 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
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|
G
|
Irf3
|
interferon regulatory factor 3
|
multiple interactions
|
ISO EXP
|
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein; scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA]
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CTD |
PMID:23535186 PMID:29405769 |
|
NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401
|
|
G
|
Itpr3
|
inositol 1,4,5-trisphosphate receptor, type 3
|
multiple interactions increases expression
|
EXP
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agomelatine inhibits the reaction [Galactose results in increased expression of ITPR3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of ITPR3 protein]
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CTD |
PMID:34673010 |
|
NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184
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G
|
Jun
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Jun proto-oncogene, AP-1 transcription factor subunit
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multiple interactions
|
ISO
|
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] affects the localization of and results in increased expression of JUN protein modified form; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of JUN protein modified form]
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CTD |
PMID:23535186 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
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G
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Keap1
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Kelch-like ECH-associated protein 1
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increases expression multiple interactions
|
ISO
|
Galactose results in increased expression of KEAP1 mRNA; Galactose results in increased expression of KEAP1 protein albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA]; albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein]
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CTD |
PMID:33761044 |
|
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
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G
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Lct
|
lactase
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increases hydrolysis
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EXP
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LCT protein results in increased hydrolysis of Galactose
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CTD |
PMID:14701853 |
|
NCBI chr13:42,334,347...42,376,872
Ensembl chr13:42,334,347...42,376,872
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|
G
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Lrp1
|
LDL receptor related protein 1
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multiple interactions decreases expression
|
ISO
|
[Ethanol co-treated with Galactose] results in decreased expression of LRP1 protein Galactose results in decreased expression of LRP1 protein
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CTD |
PMID:33516661 |
|
NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196
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G
|
Lrp6
|
LDL receptor related protein 6
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multiple interactions
|
ISO
|
[Galactose co-treated with gentiopicroside analog] results in increased expression of LRP6 protein
|
CTD |
PMID:36878094 |
|
NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716
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G
|
Mapk1
|
mitogen activated protein kinase 1
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increases phosphorylation multiple interactions
|
EXP
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Galactose results in increased phosphorylation of MAPK1 protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased phosphorylation of MAPK1 protein]
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CTD |
PMID:30367734 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
|
Mapk3
|
mitogen activated protein kinase 3
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increases phosphorylation multiple interactions
|
EXP
|
Galactose results in increased phosphorylation of MAPK3 protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:30367734 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions increases expression
|
EXP
|
Galactose promotes the reaction [sodium arsenite results in increased expression of MAPK8 mRNA] Galactose results in increased expression of MAPK8 mRNA
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CTD |
PMID:35259467 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
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G
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Mapt
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microtubule-associated protein tau
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increases expression multiple interactions
|
ISO
|
Galactose results in increased expression of MAPT protein gentiopicroside analog inhibits the reaction [Galactose results in increased expression of MAPT protein]
|
CTD |
PMID:36878094 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
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G
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Mfn2
|
mitofusin 2
|
increases expression multiple interactions
|
EXP ISO
|
Galactose results in increased expression of MFN2 protein MIR34A mRNA promotes the reaction [Galactose results in increased expression of MFN2 protein]
|
CTD |
PMID:28302704 |
|
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
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G
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Mir34a
|
microRNA 34a
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increases expression multiple interactions
|
EXP ISO
|
Galactose results in increased expression of MIR34A mRNA MIR34A mRNA promotes the reaction [Galactose results in decreased expression of ATG7 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of DNM1L protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of MFN2 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of SQSTM1 protein]
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CTD |
PMID:28302704 |
|
NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053
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G
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Mmp2
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matrix metallopeptidase 2
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multiple interactions increases activity
|
EXP
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Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased activity of MMP2 protein]
|
CTD |
PMID:30367734 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
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G
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Mmp9
|
matrix metallopeptidase 9
|
multiple interactions decreases expression
|
EXP
|
agomelatine inhibits the reaction [Galactose results in decreased expression of MMP9 protein]; Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of and results in increased activity of MMP9 protein]; Galactose results in increased expression of and results in increased activity of MMP9 protein; Melatonin inhibits the reaction [Galactose results in decreased expression of MMP9 protein]
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CTD |
PMID:30367734 PMID:34673010 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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|
G
|
Mt-co1
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mitochondrially encoded cytochrome c oxidase I
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multiple interactions
|
EXP
|
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of COX1 protein
|
CTD |
PMID:25997894 |
|
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853
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|
G
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Mt-nd4
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mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
|
affects metabolic processing
|
ISO
|
ND4 protein affects the metabolism of Galactose
|
CTD |
PMID:8662757 |
|
NCBI chr MT:10,160...11,537
Ensembl chr MT:10,145...11,522
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G
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Mt-nd6
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mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
|
affects metabolic processing
|
ISO
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ND6 protein affects the metabolism of Galactose
|
CTD |
PMID:9707444 |
|
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,531...14,049
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G
|
Myd88
|
MYD88, innate immune signal transduction adaptor
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multiple interactions
|
ISO EXP
|
[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA]
|
CTD |
PMID:23535186 PMID:29405769 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
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G
|
Ndufb8
|
NADH:ubiquinone oxidoreductase subunit B8
|
multiple interactions
|
EXP
|
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of NDUFB8 protein
|
CTD |
PMID:25997894 |
|
NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936
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G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
affects localization multiple interactions decreases expression
|
EXP ISO
|
Galactose affects the localization of NFE2L2 protein albicanol inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; albicanol inhibits the reaction [Galactose results in decreased expression of NFE2L2 protein]; theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; torularhodin inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; torularhodin inhibits the reaction [Galactose results in decreased expression of NFE2L2 protein]; Vitamin E inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; Vitamin E inhibits the reaction [Galactose results in decreased expression of NFE2L2 protein] Galactose results in decreased expression of NFE2L2 mRNA; Galactose results in decreased expression of NFE2L2 protein Saponins inhibits the reaction [Galactose affects the localization of NFE2L2 protein]
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CTD |
PMID:25892055 PMID:31431007 PMID:33761044 PMID:36638877 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
increases expression multiple interactions
|
ISO EXP
|
Galactose results in increased expression of NFKB1 mRNA; Galactose results in increased expression of NFKB1 protein Galactose promotes the reaction [sodium arsenite results in increased expression of NFKB1 mRNA]
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CTD |
PMID:22687555 PMID:35259467 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
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|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions increases activity increases expression
|
ISO
|
Oligopeptides inhibits the reaction [Galactose results in increased activity of NOS2 protein] Galactose results in increased expression of NOS2 mRNA
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CTD |
PMID:23796539 PMID:28974442 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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|
G
|
Notch1
|
notch receptor 1
|
multiple interactions
|
ISO
|
[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein]
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CTD |
PMID:35537655 |
|
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613
|
|
G
|
Nox4
|
NADPH oxidase 4
|
increases expression multiple interactions
|
EXP
|
Galactose results in increased expression of NOX4 protein agomelatine inhibits the reaction [Galactose results in increased expression of NOX4 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of NOX4 protein]
|
CTD |
PMID:34673010 |
|
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions decreases expression
|
EXP ISO
|
Saponins inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA] albicanol inhibits the reaction [Galactose results in decreased expression of NQO1 protein]; Lycopene inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA]; torularhodin inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA]; Vitamin E inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA]
|
CTD |
PMID:25892055 PMID:28974442 PMID:31431007 PMID:33761044 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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|
G
|
Oat
|
ornithine aminotransferase
|
multiple interactions
|
EXP
|
Galactose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
|
CTD |
PMID:2827574 |
|
NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754
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|
G
|
Ocln
|
occludin
|
decreases expression
|
ISO
|
Galactose results in decreased expression of OCLN protein
|
CTD |
PMID:33516661 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
|
|
G
|
Pdk1
|
pyruvate dehydrogenase kinase 1
|
multiple interactions
|
ISO
|
Galactose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]
|
CTD |
PMID:31654802 |
|
NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
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|
G
|
Pkm
|
pyruvate kinase M1/2
|
multiple interactions
|
ISO
|
Galactose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]
|
CTD |
PMID:31654802 |
|
NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396
|
|
G
|
Plau
|
plasminogen activator, urokinase
|
increases expression multiple interactions
|
EXP
|
Galactose results in increased expression of PLAU protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of PLAU protein]
|
CTD |
PMID:30367734 |
|
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
decreases expression
|
EXP
|
Galactose results in decreased expression of PPARGC1A protein
|
CTD |
PMID:28302704 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
|
|
G
|
Prdx2
|
peroxiredoxin 2
|
multiple interactions decreases expression
|
ISO
|
theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of PRDX2 mRNA]
|
CTD |
PMID:36638877 |
|
NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006
|
|
G
|
Psenen
|
presenilin enhancer gamma secretase subunit
|
multiple interactions increases expression
|
ISO
|
gentiopicroside analog inhibits the reaction [Galactose results in increased expression of PSENEN protein]
|
CTD |
PMID:36878094 |
|
NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:94,942,225...94,943,752
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions increases expression
|
ISO
|
Galactose results in increased expression of and results in increased activity of PTGS2 protein; lycopene inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 protein]
|
CTD |
PMID:22687555 PMID:28974442 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Rbpj
|
recombination signal binding protein for immunoglobulin kappa J region
|
multiple interactions
|
ISO
|
[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein]
|
CTD |
PMID:35537655 |
|
NCBI chr14:61,551,366...61,736,220
Ensembl chr14:61,551,366...61,736,307
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions affects localization increases expression
|
ISO
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[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; Galactose results in increased expression of and results in increased activity of RELA protein; protocatechuic acid inhibits the reaction [Galactose results in increased expression of and results in increased activity of RELA protein]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein]; torularhodin inhibits the reaction [Galactose results in increased expression of RELA protein]; Vitamin E inhibits the reaction [Galactose results in increased expression of RELA protein] ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein]; SB 203580 inhibits the reaction [Galactose affects the localization of RELA protein] Galactose results in increased expression of RELA mRNA; Galactose results in increased expression of RELA protein
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CTD |
PMID:22687555 PMID:23535186 PMID:29412148 PMID:31431007 PMID:35537655 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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G
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Rest
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RE1-silencing transcription factor
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multiple interactions decreases expression
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ISO
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gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of REST protein]
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CTD |
PMID:36878094 |
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NCBI chr14:31,213,415...31,233,451
Ensembl chr14:31,213,415...31,248,662
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G
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Rnf31
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ring finger protein 31
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multiple interactions
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ISO
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[Lipopolysaccharides co-treated with Galactose] results in increased expression of RNF31 protein; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNF protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein]
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CTD |
PMID:34416243 |
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NCBI chr15:33,053,450...33,065,285
Ensembl chr15:33,053,607...33,065,284
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G
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Sirt1
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sirtuin 1
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multiple interactions decreases expression
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EXP ISO
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Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]
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CTD |
PMID:25892055 PMID:27358235 PMID:29426000 |
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NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
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G
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Slc2a2
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solute carrier family 2 member 2
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increases transport
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ISO
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SLC2A2 protein results in increased transport of Galactose
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CTD |
PMID:8457197 |
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NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467
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G
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Slc2a3
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solute carrier family 2 member 3
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increases transport multiple interactions
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ISO
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SLC2A3 protein results in increased transport of Galactose Galactose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]; Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]
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CTD |
PMID:8457197 |
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NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186
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G
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Slc5a1
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solute carrier family 5 member 1
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multiple interactions affects transport
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ISO
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Galactose inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside] SLC5A1 protein affects the transport of Galactose
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CTD |
PMID:16300400 PMID:17288452 |
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NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624
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G
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Sod1
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superoxide dismutase 1
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multiple interactions decreases expression
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ISO EXP
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theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of SOD1 mRNA] [Galactose co-treated with Finasteride] results in increased expression of SOD1 mRNA
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CTD |
PMID:36638877 PMID:39265715 |
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
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G
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Sod2
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superoxide dismutase 2
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decreases expression multiple interactions
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EXP ISO
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Galactose results in decreased expression of SOD2 mRNA Saponins inhibits the reaction [Galactose results in decreased expression of SOD2 mRNA] albicanol inhibits the reaction [Galactose results in decreased expression of SOD2 protein]
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CTD |
PMID:25892055 PMID:33761044 |
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
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G
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Sord
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sorbitol dehydrogenase
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increases expression
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ISO
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Galactose results in increased expression of SORD mRNA
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CTD |
PMID:22687555 |
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NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100
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G
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Sp1
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Sp1 transcription factor
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multiple interactions increases expression
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EXP
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Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein]
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CTD |
PMID:30367734 |
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NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513
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G
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Sqstm1
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sequestosome 1
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multiple interactions increases expression
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ISO EXP
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Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of SQSTM1 protein] (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]
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CTD |
PMID:28302704 PMID:29426000 PMID:36792013 |
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
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G
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Srebf1
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sterol regulatory element binding transcription factor 1
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increases expression
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ISO
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Galactose results in increased expression of SREBF1 mRNA
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CTD |
PMID:10913129 |
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NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
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G
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Tfam
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transcription factor A, mitochondrial
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multiple interactions
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EXP
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[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of TFAM protein
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CTD |
PMID:25997894 |
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NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
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G
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Tfeb
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transcription factor EB
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multiple interactions affects localization
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ISO
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(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose affects the localization of TFEB protein]
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CTD |
PMID:36792013 |
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NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863
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G
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Tgfb1
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transforming growth factor, beta 1
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multiple interactions increases expression
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EXP
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Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of TGFB1 protein]
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CTD |
PMID:30367734 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
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Ticam1
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TIR domain containing adaptor molecule 1
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multiple interactions
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ISO EXP
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[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA]
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CTD |
PMID:23535186 PMID:29405769 |
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NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892
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G
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Tjp1
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tight junction protein 1
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decreases expression multiple interactions
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ISO
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Galactose results in decreased expression of TJP1 protein Ethanol promotes the reaction [Galactose results in decreased expression of TJP1 protein]
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CTD |
PMID:33516661 |
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NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
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G
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Tlr2
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toll-like receptor 2
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multiple interactions
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EXP
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[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA]
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CTD |
PMID:29405769 |
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NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
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G
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Tlr4
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toll-like receptor 4
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multiple interactions
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ISO EXP
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[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA]
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CTD |
PMID:23535186 PMID:29405769 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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G
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Tnf
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tumor necrosis factor
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multiple interactions increases secretion increases expression
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ISO EXP
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[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Lipopolysaccharides co-treated with Galactose] results in increased expression of TNF protein; albicanol inhibits the reaction [Galactose results in increased expression of TNF mRNA]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; catalpol inhibits the reaction [Galactose results in increased expression of TNF protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; Lycopene inhibits the reaction [Galactose results in increased expression of TNF protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of TNF protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNF protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein] Galactose results in increased expression of TNF mRNA; Galactose results in increased expression of TNF protein [Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein; candesartan inhibits the reaction [Galactose results in increased expression of TNF mRNA]; Galactose promotes the reaction [sodium arsenite results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]
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CTD |
PMID:22687555 PMID:23535186 PMID:23612000 PMID:28974442 PMID:29405769 PMID:33761044 PMID:34416243 PMID:34906534 PMID:35259467 PMID:35537655 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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G
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Tnfaip3
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TNF alpha induced protein 3
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multiple interactions
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ISO
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[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein]
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CTD |
PMID:34416243 |
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NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979
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G
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Tp53
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tumor protein p53
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multiple interactions increases expression
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ISO EXP
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Phycocyanin inhibits the reaction [Galactose results in increased expression of TP53 protein] [Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Finasteride inhibits the reaction [Galactose results in increased expression of TP53 protein]
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CTD |
PMID:23036742 PMID:25997894 PMID:29426000 PMID:39265715 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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G
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Txnip
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thioredoxin interacting protein
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multiple interactions increases expression
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ISO
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Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]; Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]
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CTD |
PMID:29426000 |
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NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
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G
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Txnrd1
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thioredoxin reductase 1
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decreases expression multiple interactions
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ISO
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Galactose results in decreased expression of TXNRD1 mRNA sodium bisulfide inhibits the reaction [Galactose results in decreased expression of TXNRD1 mRNA]
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CTD |
PMID:23274001 |
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NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
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G
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Cxcl10
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C-X-C motif chemokine ligand 10
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increases expression
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ISO
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KRN 7000 results in increased expression of CXCL10 protein
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CTD |
PMID:15867097 |
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NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
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G
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Il12b
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interleukin 12B
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increases expression
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ISO
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KRN 7000 results in increased expression of IL12B protein
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CTD |
PMID:15867097 |
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NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
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G
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Galk1
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galactokinase 1
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multiple interactions
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ISO
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[Enzyme Inhibitors binds to and results in decreased activity of GALK1 protein] which results in decreased abundance of galactose-1-phosphate; [GALK1 protein results in increased metabolism of Galactose] which results in increased abundance of galactose-1-phosphate
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CTD |
PMID:20696150 |
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NCBI chr10:101,742,067...101,746,244
Ensembl chr10:101,735,061...101,746,258
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