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G |
Ache |
acetylcholinesterase |
increases activity multiple interactions |
ISO |
Galactose results in increased activity of ACHE protein catalpol inhibits the reaction [Galactose results in increased activity of ACHE protein]; theaflavin-3,3'-digallate inhibits the reaction [Galactose results in increased activity of ACHE protein] |
CTD |
PMID:23612000 PMID:36638877 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ager |
advanced glycosylation end product-specific receptor |
increases expression decreases expression multiple interactions |
ISO EXP |
Galactose results in increased expression of AGER mRNA; Galactose results in increased expression of AGER protein Galactose results in decreased expression of AGER protein [Ethanol co-treated with Galactose] results in decreased expression of AGER protein agomelatine inhibits the reaction [Galactose results in increased expression of AGER protein] |
CTD |
PMID:22687555 PMID:33516661 PMID:34673010 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Aif1 |
allograft inflammatory factor 1 |
increases expression multiple interactions |
ISO EXP |
Galactose results in increased expression of AIF1 protein lycopene inhibits the reaction [Galactose results in increased expression of AIF1 protein] agomelatine inhibits the reaction [Galactose results in increased expression of AIF1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of AIF1 protein] |
CTD |
PMID:28974442 PMID:34673010 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
multiple interactions increases expression |
ISO |
protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA] |
CTD |
PMID:22687555 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Aox1 |
aldehyde oxidase 1 |
increases expression multiple interactions |
ISO |
Galactose results in increased expression of AOX1 mRNA sodium bisulfide inhibits the reaction [Galactose results in increased expression of AOX1 mRNA] |
CTD |
PMID:23274001 |
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NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein] |
CTD |
PMID:35537655 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp4 |
aquaporin 4 |
multiple interactions |
ISO |
[Ethanol co-treated with Galactose] results in decreased expression of AQP4 protein |
CTD |
PMID:33516661 |
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NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO |
[Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of ATF4 protein] |
CTD |
PMID:29427785 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atg5 |
autophagy related 5 |
decreases expression multiple interactions |
EXP |
Galactose results in decreased expression of ATG5 mRNA candesartan inhibits the reaction [Galactose results in decreased expression of ATG5 mRNA] |
CTD |
PMID:34906534 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atg7 |
autophagy related 7 |
decreases expression multiple interactions |
EXP ISO |
Galactose results in decreased expression of ATG7 protein MIR34A mRNA promotes the reaction [Galactose results in decreased expression of ATG7 protein] |
CTD |
PMID:28302704 |
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NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Atox1 |
antioxidant 1 copper chaperone |
decreases expression multiple interactions |
ISO |
Galactose results in decreased expression of ATOX1 mRNA sodium bisulfide inhibits the reaction [Galactose results in decreased expression of ATOX1 mRNA] |
CTD |
PMID:23274001 |
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NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions |
EXP |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of ATP5F1A protein |
CTD |
PMID:25997894 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO EXP |
Phycocyanin inhibits the reaction [Galactose results in increased expression of BAX protein] Galactose results in increased expression of BAX mRNA; Galactose results in increased expression of BAX protein agomelatine inhibits the reaction [Galactose results in increased expression of BAX protein]; Galactose promotes the reaction [sodium arsenite results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Galactose results in increased expression of BAX protein]; Saponins inhibits the reaction [Galactose results in increased expression of BAX protein] |
CTD |
PMID:23036742 PMID:25892055 PMID:34673010 PMID:35259467 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO EXP |
Phycocyanin inhibits the reaction [Galactose results in decreased expression of BCL2 protein] agomelatine inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Galactose promotes the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Galactose results in decreased expression of BCL2 protein]; Saponins inhibits the reaction [Galactose results in decreased expression of BCL2 protein] Galactose results in decreased expression of BCL2 mRNA; Galactose results in decreased expression of BCL2 protein |
CTD |
PMID:23036742 PMID:25892055 PMID:34673010 PMID:35259467 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression multiple interactions |
ISO |
Galactose results in decreased expression of BDNF mRNA; Galactose results in decreased expression of BDNF protein lycopene inhibits the reaction [Galactose results in decreased expression of BDNF mRNA]; lycopene inhibits the reaction [Galactose results in decreased expression of BDNF protein] |
CTD |
PMID:28974442 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
multiple interactions decreases expression |
EXP |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in decreased expression of BECN1 protein]; candesartan inhibits the reaction [Galactose results in decreased expression of BECN1 mRNA] Galactose results in decreased expression of BECN1 mRNA; Galactose results in decreased expression of BECN1 protein |
CTD |
PMID:25997894 PMID:28302704 PMID:34906534 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp12 |
caspase 12 |
multiple interactions increases expression |
EXP |
agomelatine inhibits the reaction [Galactose results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP12 protein] |
CTD |
PMID:34673010 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases activity increases expression |
ISO EXP |
Galactose results in increased cleavage of CASP3 protein Phycocyanin inhibits the reaction [Galactose results in increased cleavage of CASP3 protein] Galactose results in increased activity of CASP3 protein albicanol inhibits the reaction [Galactose results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Galactose results in increased activity of CASP3 protein] [Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CASP3 protein] |
CTD |
PMID:23036742 PMID:23795773 PMID:25997894 PMID:32295448 PMID:33761044 PMID:34673010 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
EXP ISO |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein] Galactose results in increased expression of CASP9 protein albicanol inhibits the reaction [Galactose results in increased expression of CASP9 mRNA] |
CTD |
PMID:25997894 PMID:32295448 PMID:33761044 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
increases activity multiple interactions decreases activity affects activity |
EXP ISO |
Galactose results in increased activity of CAT protein candesartan inhibits the reaction [Galactose results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Galactose results in increased activity of CAT protein] [Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein; albicanol inhibits the reaction [Galactose results in decreased activity of CAT protein]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein] Galactose affects the activity of CAT protein |
CTD |
PMID:17211565 PMID:32295448 PMID:33761044 PMID:34906534 PMID:35537655 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression multiple interactions |
EXP |
Galactose results in increased expression of CCN2 protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of CCN2 protein] |
CTD |
PMID:30367734 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Cdh5 |
cadherin 5 |
multiple interactions decreases expression |
ISO |
Ethanol promotes the reaction [Galactose results in decreased expression of CDH5 protein] |
CTD |
PMID:33516661 |
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NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
increases expression multiple interactions |
ISO |
Galactose results in increased expression of CDK5R1 protein gentiopicroside analog inhibits the reaction [Galactose results in increased expression of CDK5R1 protein] |
CTD |
PMID:36878094 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions increases expression |
EXP ISO |
agomelatine inhibits the reaction [Galactose results in increased expression of CDKN2A protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CDKN2A protein] (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]] |
CTD |
PMID:34673010 PMID:36792013 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Chat |
choline O-acetyltransferase |
multiple interactions decreases activity |
ISO |
catalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein] |
CTD |
PMID:23612000 |
|
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions decreases expression |
ISO |
catalpol inhibits the reaction [Galactose results in decreased expression of CHRM1 protein] |
CTD |
PMID:23612000 |
|
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression |
ISO |
gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of CTNNB1 protein] |
CTD |
PMID:36878094 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cybb |
cytochrome b-245 beta chain |
increases expression multiple interactions |
EXP |
Galactose results in increased expression of CYBB protein agomelatine inhibits the reaction [Galactose results in increased expression of CYBB protein]; Melatonin inhibits the reaction [Galactose results in increased expression of CYBB protein] |
CTD |
PMID:34673010 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO EXP |
[Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of DDIT3 protein]; Phycocyanin inhibits the reaction [Galactose results in increased expression of DDIT3 protein] agomelatine inhibits the reaction [Galactose results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of DDIT3 protein] |
CTD |
PMID:23036742 PMID:29427785 PMID:34673010 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnm1l |
dynamin 1-like |
increases expression multiple interactions |
ISO EXP |
Galactose results in increased expression of DNM1L protein MIR34A mRNA promotes the reaction [Galactose results in increased expression of DNM1L protein] |
CTD |
PMID:28302704 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
EXP |
agomelatine inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein]; Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:34673010 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases phosphorylation multiple interactions |
EXP |
Galactose results in increased phosphorylation of ERN1 protein agomelatine inhibits the reaction [Galactose results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:34673010 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions increases expression |
EXP |
Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of FGF2 protein] |
CTD |
PMID:30367734 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Galk1 |
galactokinase 1 |
multiple interactions increases metabolic processing |
ISO |
[GALK1 protein results in increased metabolism of Galactose] which results in increased abundance of galactose-1-phosphate |
CTD |
PMID:20696150 |
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NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337
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G |
Gap43 |
growth associated protein 43 |
decreases expression multiple interactions |
ISO |
Galactose results in decreased expression of GAP43 mRNA Quercetin inhibits the reaction [Galactose results in decreased expression of GAP43 mRNA] |
CTD |
PMID:16707173 |
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NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases expression multiple interactions |
EXP |
Galactose results in decreased expression of GCLC mRNA Saponins inhibits the reaction [Galactose results in decreased expression of GCLC mRNA] |
CTD |
PMID:25892055 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gdnf |
glial cell derived neurotrophic factor |
multiple interactions decreases expression |
EXP |
candesartan inhibits the reaction [Galactose results in decreased expression of GDNF mRNA] |
CTD |
PMID:34906534 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
EXP |
agomelatine inhibits the reaction [Galactose results in increased expression of GFAP protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GFAP protein] |
CTD |
PMID:34673010 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Glb1 |
galactosidase, beta 1 |
increases expression multiple interactions |
ISO |
Galactose results in increased expression of GLB1 protein (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]] |
CTD |
PMID:36792013 |
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NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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G |
Glo1 |
glyoxalase 1 |
multiple interactions |
ISO |
Galactose results in decreased expression of and results in decreased activity of GLO1 protein; protocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein] |
CTD |
PMID:22687555 |
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NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein] |
CTD |
PMID:34416243 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions decreases expression |
ISO |
theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of GPX1 mRNA] |
CTD |
PMID:36638877 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
increases expression multiple interactions |
EXP |
Galactose results in increased expression of GRIN1 protein agomelatine inhibits the reaction [Galactose results in increased expression of GRIN1 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GRIN1 protein] |
CTD |
PMID:34673010 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
increases expression multiple interactions |
EXP |
Galactose results in increased expression of GRIN2B protein agomelatine inhibits the reaction [Galactose results in increased expression of GRIN2B protein]; Melatonin inhibits the reaction [Galactose results in increased expression of GRIN2B protein] |
CTD |
PMID:34673010 |
|
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
Galactose results in increased expression of and results in decreased phosphorylation of GSK3B protein; gentiopicroside analog inhibits the reaction [Galactose results in increased expression of and results in decreased phosphorylation of GSK3B protein] |
CTD |
PMID:36878094 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gss |
glutathione synthetase |
multiple interactions decreases expression |
ISO |
sodium bisulfide inhibits the reaction [Galactose results in decreased expression of GSS mRNA] |
CTD |
PMID:23274001 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
ISO |
[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein] |
CTD |
PMID:35537655 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Galactose affects the reaction [Fusaric Acid affects the expression of HIF1A protein] |
CTD |
PMID:31654802 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions decreases expression |
EXP ISO |
Saponins inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA] albicanol inhibits the reaction [Galactose results in decreased expression of HMOX1 protein]; Lycopene inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:25892055 PMID:28974442 PMID:33761044 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Galactose results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO EXP |
Phycocyanin inhibits the reaction [Galactose results in increased expression of HSPA5 protein] Melatonin inhibits the reaction [Galactose results in increased expression of HSPA5 protein] |
CTD |
PMID:23036742 PMID:34673010 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein; scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein] |
CTD |
PMID:23535186 |
|
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein] |
CTD |
PMID:35537655 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
increases expression increases secretion multiple interactions |
ISO EXP |
Galactose results in increased expression of IL1B mRNA; Galactose results in increased expression of IL1B protein Galactose results in increased secretion of IL1B protein [Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein; albicanol inhibits the reaction [Galactose results in increased expression of IL1B mRNA]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; catalpol inhibits the reaction [Galactose results in increased expression of IL1B protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; Lycopene inhibits the reaction [Galactose results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL1B protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein] |
CTD |
PMID:22687555 PMID:23612000 PMID:28974442 PMID:29405769 PMID:32295448 PMID:33761044 PMID:35537655 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6 |
interleukin 6 |
multiple interactions increases secretion increases expression |
ISO EXP |
[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein; [Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL6 protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein] 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside M1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] Galactose results in increased expression of IL6 mRNA; Galactose results in increased expression of IL6 protein Galactose promotes the reaction [sodium arsenite results in increased expression of IL6 mRNA] |
CTD |
PMID:22687555 PMID:23535186 PMID:29412148 PMID:32295448 PMID:34416243 PMID:35259467 PMID:35537655 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO EXP |
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein; scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IRF3 mRNA] |
CTD |
PMID:23535186 PMID:29405769 |
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NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Itpr3 |
inositol 1,4,5-trisphosphate receptor, type 3 |
multiple interactions increases expression |
EXP |
agomelatine inhibits the reaction [Galactose results in increased expression of ITPR3 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of ITPR3 protein] |
CTD |
PMID:34673010 |
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NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] affects the localization of and results in increased expression of JUN protein modified form; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of JUN protein modified form] |
CTD |
PMID:23535186 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression multiple interactions |
ISO |
Galactose results in increased expression of KEAP1 mRNA; Galactose results in increased expression of KEAP1 protein albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA]; albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] |
CTD |
PMID:33761044 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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Lct |
lactase |
increases hydrolysis |
EXP |
LCT protein results in increased hydrolysis of Galactose |
CTD |
PMID:14701853 |
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NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456
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G |
Lrp1 |
LDL receptor related protein 1 |
multiple interactions decreases expression |
ISO |
[Ethanol co-treated with Galactose] results in decreased expression of LRP1 protein Galactose results in decreased expression of LRP1 protein |
CTD |
PMID:33516661 |
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NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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G |
Lrp6 |
LDL receptor related protein 6 |
multiple interactions |
ISO |
[Galactose co-treated with gentiopicroside analog] results in increased expression of LRP6 protein |
CTD |
PMID:36878094 |
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NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
EXP |
Galactose results in increased phosphorylation of MAPK1 protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:30367734 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
EXP |
Galactose results in increased phosphorylation of MAPK3 protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:30367734 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases expression |
EXP |
Galactose promotes the reaction [sodium arsenite results in increased expression of MAPK8 mRNA] Galactose results in increased expression of MAPK8 mRNA |
CTD |
PMID:35259467 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapt |
microtubule-associated protein tau |
increases expression multiple interactions |
ISO |
Galactose results in increased expression of MAPT protein gentiopicroside analog inhibits the reaction [Galactose results in increased expression of MAPT protein] |
CTD |
PMID:36878094 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mfn2 |
mitofusin 2 |
increases expression multiple interactions |
EXP ISO |
Galactose results in increased expression of MFN2 protein MIR34A mRNA promotes the reaction [Galactose results in increased expression of MFN2 protein] |
CTD |
PMID:28302704 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mir34a |
microRNA 34a |
increases expression multiple interactions |
EXP ISO |
Galactose results in increased expression of MIR34A mRNA MIR34A mRNA promotes the reaction [Galactose results in decreased expression of ATG7 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of DNM1L protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of MFN2 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of SQSTM1 protein] |
CTD |
PMID:28302704 |
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NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions increases activity |
EXP |
Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased activity of MMP2 protein] |
CTD |
PMID:30367734 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
EXP |
agomelatine inhibits the reaction [Galactose results in decreased expression of MMP9 protein]; Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of and results in increased activity of MMP9 protein]; Galactose results in increased expression of and results in increased activity of MMP9 protein; Melatonin inhibits the reaction [Galactose results in decreased expression of MMP9 protein] |
CTD |
PMID:30367734 PMID:34673010 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
multiple interactions |
EXP |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of COX1 protein |
CTD |
PMID:25997894 |
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NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-nd4 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 |
affects metabolic processing |
ISO |
ND4 protein affects the metabolism of Galactose |
CTD |
PMID:8662757 |
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NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
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Mt-nd6 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 |
affects metabolic processing |
ISO |
ND6 protein affects the metabolism of Galactose |
CTD |
PMID:9707444 |
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NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO EXP |
[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of MYD88 mRNA] |
CTD |
PMID:23535186 PMID:29405769 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Ndufb8 |
NADH:ubiquinone oxidoreductase subunit B8 |
multiple interactions |
EXP |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of NDUFB8 protein |
CTD |
PMID:25997894 |
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NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization multiple interactions decreases expression |
EXP ISO |
Galactose affects the localization of NFE2L2 protein albicanol inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA]; albicanol inhibits the reaction [Galactose results in decreased expression of NFE2L2 protein]; theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of NFE2L2 mRNA] Galactose results in decreased expression of NFE2L2 mRNA; Galactose results in decreased expression of NFE2L2 protein Saponins inhibits the reaction [Galactose affects the localization of NFE2L2 protein] |
CTD |
PMID:25892055 PMID:33761044 PMID:36638877 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1 |
nuclear factor kappa B subunit 1 |
increases expression multiple interactions |
ISO EXP |
Galactose results in increased expression of NFKB1 mRNA; Galactose results in increased expression of NFKB1 protein Galactose promotes the reaction [sodium arsenite results in increased expression of NFKB1 mRNA] |
CTD |
PMID:22687555 PMID:35259467 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nos2 |
nitric oxide synthase 2 |
multiple interactions increases activity increases expression |
ISO |
Oligopeptides inhibits the reaction [Galactose results in increased activity of NOS2 protein] Galactose results in increased expression of NOS2 mRNA |
CTD |
PMID:23796539 PMID:28974442 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Notch1 |
notch receptor 1 |
multiple interactions |
ISO |
[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein] |
CTD |
PMID:35537655 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nox4 |
NADPH oxidase 4 |
increases expression multiple interactions |
EXP |
Galactose results in increased expression of NOX4 protein agomelatine inhibits the reaction [Galactose results in increased expression of NOX4 protein]; Melatonin inhibits the reaction [Galactose results in increased expression of NOX4 protein] |
CTD |
PMID:34673010 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions decreases expression |
EXP ISO |
Saponins inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA] albicanol inhibits the reaction [Galactose results in decreased expression of NQO1 protein]; Lycopene inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA] |
CTD |
PMID:25892055 PMID:28974442 PMID:33761044 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Oat |
ornithine aminotransferase |
multiple interactions |
EXP |
Galactose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] |
CTD |
PMID:2827574 |
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NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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G |
Ocln |
occludin |
decreases expression |
ISO |
Galactose results in decreased expression of OCLN protein |
CTD |
PMID:33516661 |
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NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions |
ISO |
Galactose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein] |
CTD |
PMID:31654802 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions |
ISO |
Galactose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA] |
CTD |
PMID:31654802 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Plau |
plasminogen activator, urokinase |
increases expression multiple interactions |
EXP |
Galactose results in increased expression of PLAU protein Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of PLAU protein] |
CTD |
PMID:30367734 |
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NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression |
EXP |
Galactose results in decreased expression of PPARGC1A protein |
CTD |
PMID:28302704 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prdx2 |
peroxiredoxin 2 |
multiple interactions decreases expression |
ISO |
theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of PRDX2 mRNA] |
CTD |
PMID:36638877 |
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NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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G |
Psenen |
presenilin enhancer gamma secretase subunit |
multiple interactions increases expression |
ISO |
gentiopicroside analog inhibits the reaction [Galactose results in increased expression of PSENEN protein] |
CTD |
PMID:36878094 |
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NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
Galactose results in increased expression of and results in increased activity of PTGS2 protein; lycopene inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 protein] |
CTD |
PMID:22687555 PMID:28974442 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rbpj |
recombination signal binding protein for immunoglobulin kappa J region |
multiple interactions |
ISO |
[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein] |
CTD |
PMID:35537655 |
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NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization increases expression |
ISO |
[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; Galactose results in increased expression of and results in increased activity of RELA protein; protocatechuic acid inhibits the reaction [Galactose results in increased expression of and results in increased activity of RELA protein]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein] ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein]; SB 203580 inhibits the reaction [Galactose affects the localization of RELA protein] Galactose results in increased expression of RELA mRNA; Galactose results in increased expression of RELA protein |
CTD |
PMID:22687555 PMID:23535186 PMID:29412148 PMID:35537655 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rest |
RE1-silencing transcription factor |
multiple interactions decreases expression |
ISO |
gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of REST protein] |
CTD |
PMID:36878094 |
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NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354
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G |
Rnf31 |
ring finger protein 31 |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Galactose] results in increased expression of RNF31 protein; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNF protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein] |
CTD |
PMID:34416243 |
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NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915
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G |
Sirt1 |
sirtuin 1 |
multiple interactions decreases expression |
EXP ISO |
Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] |
CTD |
PMID:25892055 PMID:27358235 PMID:29426000 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc2a2 |
solute carrier family 2 member 2 |
increases transport |
ISO |
SLC2A2 protein results in increased transport of Galactose |
CTD |
PMID:8457197 |
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NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Slc2a3 |
solute carrier family 2 member 3 |
increases transport multiple interactions |
ISO |
SLC2A3 protein results in increased transport of Galactose Galactose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]; Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose] |
CTD |
PMID:8457197 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Slc5a1 |
solute carrier family 5 member 1 |
multiple interactions affects transport |
ISO |
Galactose inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside] SLC5A1 protein affects the transport of Galactose |
CTD |
PMID:16300400 PMID:17288452 |
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NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions decreases expression |
ISO |
theaflavin-3,3'-digallate inhibits the reaction [Galactose results in decreased expression of SOD1 mRNA] |
CTD |
PMID:36638877 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression multiple interactions |
EXP ISO |
Galactose results in decreased expression of SOD2 mRNA Saponins inhibits the reaction [Galactose results in decreased expression of SOD2 mRNA] albicanol inhibits the reaction [Galactose results in decreased expression of SOD2 protein] |
CTD |
PMID:25892055 PMID:33761044 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sord |
sorbitol dehydrogenase |
increases expression |
ISO |
Galactose results in increased expression of SORD mRNA |
CTD |
PMID:22687555 |
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NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions increases expression |
EXP |
Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] |
CTD |
PMID:30367734 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions increases expression |
ISO EXP |
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; MIR34A mRNA promotes the reaction [Galactose results in increased expression of SQSTM1 protein] (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]] |
CTD |
PMID:28302704 PMID:29426000 PMID:36792013 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
ISO |
Galactose results in increased expression of SREBF1 mRNA |
CTD |
PMID:10913129 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
EXP |
[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of TFAM protein |
CTD |
PMID:25997894 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tfeb |
transcription factor EB |
multiple interactions affects localization |
ISO |
(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose affects the localization of TFEB protein] |
CTD |
PMID:36792013 |
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NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions increases expression |
EXP |
Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of TGFB1 protein] |
CTD |
PMID:30367734 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Ticam1 |
TIR domain containing adaptor molecule 1 |
multiple interactions |
ISO EXP |
[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TICAM1 mRNA] |
CTD |
PMID:23535186 PMID:29405769 |
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NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
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G |
Tjp1 |
tight junction protein 1 |
decreases expression multiple interactions |
ISO |
Galactose results in decreased expression of TJP1 protein Ethanol promotes the reaction [Galactose results in decreased expression of TJP1 protein] |
CTD |
PMID:33516661 |
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NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
EXP |
[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR2 mRNA] |
CTD |
PMID:29405769 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO EXP |
[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] [Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TLR4 mRNA] |
CTD |
PMID:23535186 PMID:29405769 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases secretion increases expression |
ISO EXP |
[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Lipopolysaccharides co-treated with Galactose] results in increased expression of TNF protein; albicanol inhibits the reaction [Galactose results in increased expression of TNF mRNA]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; catalpol inhibits the reaction [Galactose results in increased expression of TNF protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; Lycopene inhibits the reaction [Galactose results in increased expression of TNF protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of TNF protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNF protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein] Galactose results in increased expression of TNF mRNA; Galactose results in increased expression of TNF protein [Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein; candesartan inhibits the reaction [Galactose results in increased expression of TNF mRNA]; Galactose promotes the reaction [sodium arsenite results in increased expression of TNF mRNA]; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein] |
CTD |
PMID:22687555 PMID:23535186 PMID:23612000 PMID:28974442 PMID:29405769 PMID:33761044 PMID:34416243 PMID:34906534 PMID:35259467 PMID:35537655 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of TNFAIP3 protein] |
CTD |
PMID:34416243 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO EXP |
Phycocyanin inhibits the reaction [Galactose results in increased expression of TP53 protein] [Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] |
CTD |
PMID:23036742 PMID:25997894 PMID:29426000 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txnip |
thioredoxin interacting protein |
multiple interactions increases expression |
ISO |
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]; Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein] |
CTD |
PMID:29426000 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Txnrd1 |
thioredoxin reductase 1 |
decreases expression multiple interactions |
ISO |
Galactose results in decreased expression of TXNRD1 mRNA sodium bisulfide inhibits the reaction [Galactose results in decreased expression of TXNRD1 mRNA] |
CTD |
PMID:23274001 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
KRN 7000 results in increased expression of CXCL10 protein |
CTD |
PMID:15867097 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
KRN 7000 results in increased expression of IL12B protein |
CTD |
PMID:15867097 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Galk1 |
galactokinase 1 |
multiple interactions |
ISO |
[Enzyme Inhibitors binds to and results in decreased activity of GALK1 protein] which results in decreased abundance of galactose-1-phosphate; [GALK1 protein results in increased metabolism of Galactose] which results in increased abundance of galactose-1-phosphate |
CTD |
PMID:20696150 |
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NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337
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