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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:melibiose
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Accession:CHEBI:28053 term browser browse the term
Definition:A glycosylglucose formed by an alpha-(1->6)-linkage between D-galactose and D-glucose.
Synonyms:exact_synonym: alpha-D-galactopyranosyl-(1->6)-D-glucopyranose
 related_synonym: (Gal)1 (Glc)1;   6-O-alpha-D-galactopyranosyl-D-glucopyranose;   D-Melibiose;   D-mellibiose;   Formula=C12H22O11;   Gal-alpha(1,6)Glc;   InChI=1S/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11?,12+/m1/s1;   InChIKey=DLRVVLDZNNYCBX-ABXHMFFYSA-N;   SMILES=OC[C@H]1O[C@H](OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O;   WURCS=2.0/2,2,1/[a2122h-1x_1-5][a2112h-1a_1-5]/1-2/a6-b1;   alpha-D-Gal-(1->6)-D-Glc;   alpha-D-Galp-(1->6)-D-Glcp;   alpha-D-galactosyl-(1->6)-D-glucose
 alt_id: CHEBI:20943;   CHEBI:25182;   CHEBI:60170;   CHEBI:6733
 xref: Beilstein:1292781;   CAS:585-99-9;   GlyGen:G09165XB;   GlyTouCan:G09165XB;   Gmelin:887780;   HMDB:HMDB0000048;   KEGG:C05402;   KEGG:G01275;   KNApSAcK:C00001142
 xref_mesh: MESH:D008553
 xref: MetaCyc:MELIBIOSE;   PMID:12797744;   PMID:17006649;   PMID:17724458;   PMID:19846069;   PMID:19913595;   PMID:27577255;   PMID:27794607;   PMID:28453942;   PMID:3290105;   PMID:718021;   PMID:7524207;   Reaxys:1292781;   Wikipedia:Melibiose


show annotations for term's descendants           Sort by:
melibiose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 increases expression ISO Melibiose results in increased expression of BAG3 mRNA CTD PMID:30335591 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Melibiose results in increased expression of HSPB8 mRNA CTD PMID:30335591 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Melibiose results in increased expression of MAP1LC3B mRNA CTD PMID:30335591 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Melibiose results in increased expression of SQSTM1 mRNA CTD PMID:30335591 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tfeb transcription factor EB affects localization
multiple interactions		 ISO Melibiose affects the localization of TFEB protein
Cyclosporine inhibits the reaction [Melibiose affects the localization of TFEB protein]		 CTD PMID:30335591 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 increases expression ISO Melibiose results in increased expression of ZKSCAN3 mRNA CTD PMID:30335591 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of BAX protein] CTD PMID:34227456 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
royal jelly inhibits the reaction [Fluorides results in increased expression of BCL2 protein]		 CTD PMID:30896085 PMID:34227456 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of BDNF protein] CTD PMID:34227456 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP3 protein]		 CTD PMID:30896085 PMID:34227456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP6 protein] CTD PMID:34227456 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP9 protein] CTD PMID:34227456 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; royal jelly inhibits the reaction [Fluorides results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241 PMID:30896085 PMID:34227456 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO royal jelly inhibits the reaction [phenylhydrazine affects the expression of CCND1 mRNA] CTD PMID:35099105 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP royal jelly inhibits the reaction [Paclitaxel results in increased expression of E2F1 mRNA] CTD PMID:27496854 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in increased expression of GSK3B protein] CTD PMID:34227456 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP royal jelly inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:18981581 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 ISO
EXP		 royal jelly inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA]
royal jelly inhibits the reaction [Paclitaxel results in decreased expression of MYC mRNA]
royal jelly results in decreased expression of MYC mRNA		 CTD PMID:27496854 PMID:35099105 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in decreased expression of NFE2L2 protein] CTD PMID:34227456 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP royal jelly inhibits the reaction [Fluorides results in increased expression of RELA protein] CTD PMID:34227456 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        pharmacological role 19106
          agonist 18622
            elastin-laminin receptor agonist 26
              melibiose 26
                alpha-D-Galp-(1->3)-[alpha-D-Galp-(1->6)]-D-Glcp 0
                beta-melibiose 0
                melibionic acid 0
                royal jelly 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbohydrates and carbohydrate derivatives 15275
                                    carbohydrate 15302
                                      oligosaccharide 625
                                        disaccharide 531
                                          glycosylglucose 220
                                            melibiose 26
                                              alpha-D-Galp-(1->3)-[alpha-D-Galp-(1->6)]-D-Glcp 0
                                              beta-melibiose 0
                                              melibionic acid 0
                                              royal jelly 20
paths to the root