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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estriol
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Accession:CHEBI:27974 term browser browse the term
Definition:A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).
Synonyms:exact_synonym: estra-1,3,5(10)-triene-3,16alpha,17beta-triol
 related_synonym: (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol;   1,3,5(10)-Estratriene-3,16-alpha,17beta-triol;   16alpha,17beta-estriol;   16alpha-hydroxyestradiol;   3,16alpha,17beta-trihydroxy-Delta(1,3,5)-estratriene;   Estriel;   Formula=C18H24O3;   InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1;   InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N;   SMILES=[H][C@]12CC[C@]3(C)[C@@H](O)[C@H](O)C[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21;   oestriol;   trihydroxyestrin
 alt_id: CHEBI:23969;   CHEBI:42467;   CHEBI:4869
 xref: CAS:50-27-1;   DrugBank:DB04573;   Drug_Central:3187;   HMDB:HMDB0000153;   KEGG:C05141;   KEGG:D00185;   LINCS:LSM-2368;   LIPID_MAPS_instance:LMST02010003
 xref_mesh: MESH:D004964
 xref: MetaCyc:ESTRIOL;   PDBeChem:ESL;   PMID:11133265;   PMID:23777262;   PMID:9373313;   Reaxys:2508172;   VSDB:1907;   Wikipedia:Estriol


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estriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
multiple interactions
increases export		 EXP Estriol results in increased expression of ABCB1 mRNA; Estriol results in increased expression of ABCB1 protein
Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estriol]		 CTD PMID:15290871 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) multiple interactions
increases expression		 EXP fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 mRNA]; fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 protein]
Estriol results in increased expression of ABCG2 mRNA; Estriol results in increased expression of ABCG2 protein		 CTD PMID:16849015 PMID:17823853 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ACRBP acrosin binding protein decreases expression ISO Estriol results in decreased expression of ACRBP mRNA CTD PMID:25575267 NCBI chr12:6,638,075...6,647,432
Ensembl chr12:6,638,075...6,647,433 		JBrowse link
G ACTC1 actin alpha cardiac muscle 1 affects expression EXP Estriol affects the expression of ACTC1 mRNA CTD PMID:23184660 NCBI chr15:34,790,230...34,795,549
Ensembl chr15:34,790,107...34,795,589 		JBrowse link
G AFP alpha fetoprotein increases expression
affects binding		 EXP
ISO		 Estriol results in increased expression of AFP protein
Estriol binds to AFP protein		 CTD PMID:2470397 PMID:18497072 PMID:23013281 PMID:25349334 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AGER advanced glycosylation end-product specific receptor increases expression EXP Estriol results in increased expression of AGER protein CTD PMID:15878629 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AGTR1 angiotensin II receptor type 1 decreases expression EXP Estriol results in decreased expression of AGTR1 mRNA CTD PMID:15159206 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AKAP17A A-kinase anchoring protein 17A decreases expression ISO Estriol results in decreased expression of AKAP17B mRNA CTD PMID:25575267 NCBI chr  X:1,591,604...1,602,520
NCBI chr  Y:1,591,604...1,602,520
Ensembl chr  Y:1,591,604...1,602,520
Ensembl chr  X:1,591,604...1,602,520 		JBrowse link
G AKIRIN1 akirin 1 increases expression ISO Estriol results in increased expression of AKIRIN1 mRNA CTD PMID:25575267 NCBI chr 1:38,991,276...39,006,059
Ensembl chr 1:38,991,276...39,006,059 		JBrowse link
G ALB albumin decreases expression ISO Estriol results in decreased expression of ALB protein CTD PMID:2470397 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G AMER1 APC membrane recruitment protein 1 decreases expression ISO Estriol results in decreased expression of AMER1 mRNA CTD PMID:25575267 NCBI chr  X:64,185,117...64,205,708
Ensembl chr  X:64,185,117...64,205,708 		JBrowse link
G AR androgen receptor affects binding
multiple interactions		 ISO
EXP		 Estriol binds to AR protein
Estriol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]		 CTD PMID:14565775 PMID:18324785 PMID:28803809 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha decreases expression EXP Estriol results in decreased expression of ARHGDIA mRNA CTD PMID:15159206 NCBI chr17:81,867,721...81,871,337
Ensembl chr17:81,867,719...81,871,378 		JBrowse link
G AURKB aurora kinase B increases expression ISO Estriol results in increased expression of AURKB mRNA CTD PMID:25575267 NCBI chr17:8,204,731...8,210,575
Ensembl chr17:8,204,733...8,210,600 		JBrowse link
G B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 decreases expression ISO Estriol results in decreased expression of B3GNTL1 mRNA CTD PMID:25575267 NCBI chr17:82,942,149...83,051,770
Ensembl chr17:82,942,149...83,051,809 		JBrowse link
G B4GALT1 beta-1,4-galactosyltransferase 1 increases expression EXP Estriol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 9:33,104,077...33,185,089
Ensembl chr 9:33,100,493...33,167,336 		JBrowse link
G BMF Bcl2 modifying factor decreases expression ISO Estriol results in decreased expression of BMF mRNA CTD PMID:25575267 NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892 		JBrowse link
G BTBD10 BTB domain containing 10 increases expression ISO Estriol results in increased expression of BTBD10 mRNA CTD PMID:25575267 NCBI chr11:13,388,008...13,463,222
Ensembl chr11:13,388,008...13,463,297 		JBrowse link
G C2CD2L C2CD2 like increases expression ISO Estriol results in increased expression of C2CD2L mRNA CTD PMID:25575267 NCBI chr11:119,102,249...119,118,544
Ensembl chr11:119,102,198...119,118,544 		JBrowse link
G CCN1 cellular communication network factor 1 increases expression ISO Estriol results in increased expression of CCN1 mRNA CTD PMID:25575267 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589 		JBrowse link
G CCNB1 cyclin B1 increases expression ISO Estriol results in increased expression of CCNB1 mRNA CTD PMID:25575267 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCNB2 cyclin B2 increases expression ISO Estriol results in increased expression of CCNB2 mRNA CTD PMID:25575267 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045 		JBrowse link
G CCNE1 cyclin E1 multiple interactions EXP Estriol inhibits the reaction [Estradiol results in increased cleavage of CCNE1 protein] CTD PMID:23624423 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CD274 CD274 molecule increases expression ISO Estriol results in increased expression of CD274 protein CTD PMID:21317386 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566 		JBrowse link
G CD276 CD276 molecule increases expression ISO Estriol results in increased expression of CD276 protein CTD PMID:21317386 NCBI chr15:73,683,944...73,714,514
Ensembl chr15:73,683,966...73,714,514 		JBrowse link
G CD80 CD80 molecule increases expression ISO Estriol results in increased expression of CD80 protein CTD PMID:21317386 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614 		JBrowse link
G CD86 CD86 molecule increases expression ISO Estriol results in increased expression of CD86 protein CTD PMID:21317386 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G CD99L2 CD99 molecule like 2 decreases expression ISO Estriol results in decreased expression of CD99L2 mRNA CTD PMID:25575267 NCBI chr  X:150,766,336...150,898,668
Ensembl chr  X:150,766,336...150,898,816 		JBrowse link
G CDC42SE1 CDC42 small effector 1 increases expression ISO Estriol results in increased expression of CDC42SE1 mRNA CTD PMID:25575267 NCBI chr 1:151,050,985...151,059,622
Ensembl chr 1:151,050,971...151,070,325 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO Estriol results in increased expression of CDKN1A mRNA CTD PMID:25575267 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CHST8 carbohydrate sulfotransferase 8 increases expression ISO Estriol results in increased expression of CHST8 mRNA CTD PMID:25575267 NCBI chr19:33,621,953...33,773,509
Ensembl chr19:33,621,953...33,773,509 		JBrowse link
G CKB creatine kinase B increases expression ISO Estriol results in increased expression of CKB CTD PMID:10030690 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833 		JBrowse link
G CNRIP1 cannabinoid receptor interacting protein 1 decreases expression ISO Estriol results in decreased expression of CNRIP1 mRNA CTD PMID:25575267 NCBI chr 2:68,284,171...68,319,949
Ensembl chr 2:68,284,171...68,320,051 		JBrowse link
G CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 increases expression ISO Estriol results in increased expression of CRISPLD2 mRNA CTD PMID:25575267 NCBI chr16:84,819,985...84,909,508
Ensembl chr16:84,819,985...84,920,768 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions
decreases expression		 EXP Estriol inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]
Estriol results in decreased expression of CYP19A1 mRNA		 CTD PMID:21296134 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Estriol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:12093619 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression ISO Estriol results in increased expression of CYP2B10 mRNA CTD PMID:7771797 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 multiple interactions EXP Estriol inhibits the reaction [imidacloprid results in increased expression of CYP3A7]; Estriol inhibits the reaction [thiacloprid results in increased expression of CYP3A7]; Estriol inhibits the reaction [thiamethoxam results in increased expression of CYP3A7] CTD PMID:28750898 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G DENND2A DENN domain containing 2A increases expression ISO Estriol results in increased expression of DENND2A mRNA CTD PMID:25575267 NCBI chr 7:140,518,419...140,641,460
Ensembl chr 7:140,518,420...140,673,993 		JBrowse link
G DTX4 deltex E3 ubiquitin ligase 4 decreases expression ISO Estriol results in decreased expression of DTX4 mRNA CTD PMID:25575267 NCBI chr11:59,171,430...59,208,588
Ensembl chr11:59,171,430...59,208,588 		JBrowse link
G EEIG1 estrogen-induced osteoclastogenesis regulator 1 increases expression EXP Estriol results in increased expression of EEIG1 mRNA CTD PMID:14605097 NCBI chr 9:127,940,582...127,980,989
Ensembl chr 9:127,940,582...127,980,989 		JBrowse link
G EGR1 early growth response 1 increases expression ISO Estriol results in increased expression of EGR1 mRNA CTD PMID:1717835 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EGR3 early growth response 3 increases expression EXP Estriol results in increased expression of EGR3 mRNA CTD PMID:15159206 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480 		JBrowse link
G EIF2S2 eukaryotic translation initiation factor 2 subunit beta increases expression ISO Estriol results in increased expression of EIF2S2 mRNA CTD PMID:25575267 NCBI chr20:34,088,309...34,112,243
Ensembl chr20:34,088,309...34,112,243 		JBrowse link
G ENO2 enolase 2 decreases expression EXP Estriol results in decreased expression of ENO2 mRNA CTD PMID:15159206 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
affects binding
increases activity
affects localization
increases expression		 EXP
ISO		 Estriol binds to and results in increased activity of ESR1 protein; Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estriol inhibits the reaction [Estradiol binds to ESR1 protein]; Estriol promotes the reaction [ESR1 protein binds to ESR1 protein]; Fulvestrant inhibits the reaction [Estriol results in increased activity of ESR1 protein]
Estriol binds to ESR1 protein
Estriol affects the localization of ESR1 protein
Estriol results in increased expression of ESR1 mRNA		 CTD PMID:9048584 PMID:11162928 PMID:11518614 PMID:12127041 PMID:12598185 More... NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
affects binding		 EXP
ISO		 Estriol binds to and results in increased activity of ESR2 protein; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]
Estriol binds to Esr2 protein
Estriol binds to ESR2 protein
Estriol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estriol inhibits the reaction [Estradiol binds to ESR2 protein]		 CTD
RGD		 PMID:8650195 PMID:9048584 PMID:9492041 PMID:9751507 PMID:11518614 More... RGD:8694130 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G ETF1 eukaryotic translation termination factor 1 increases expression ISO Estriol results in increased expression of ETF1 mRNA CTD PMID:25575267 NCBI chr 5:138,506,095...138,543,236
Ensembl chr 5:138,506,095...138,543,236 		JBrowse link
G F10 coagulation factor X increases expression EXP Estriol results in increased expression of F10 protein CTD PMID:614942 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Estriol results in increased expression of FOS mRNA CTD PMID:2118345 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G FOXA2 forkhead box A2 increases expression EXP Estriol results in increased expression of FOXA2 mRNA CTD PMID:23184660 NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,580,998...22,585,455 		JBrowse link
G GH1 growth hormone 1 increases expression ISO Estriol results in increased expression of GH1 mRNA CTD PMID:15240998 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha decreases expression EXP Estriol results in decreased expression of HNF4A mRNA CTD PMID:23184660 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845 		JBrowse link
G HOXA10 homeobox A10 decreases expression ISO Estriol results in decreased expression of HOXA10 mRNA CTD PMID:16402032 NCBI chr 7:27,170,605...27,179,861
Ensembl chr 7:27,170,605...27,180,261 		JBrowse link
G HOXA11 homeobox A11 decreases expression ISO Estriol results in decreased expression of HOXA11 mRNA CTD PMID:16402032 NCBI chr 7:27,181,157...27,185,232
Ensembl chr 7:27,181,157...27,185,232 		JBrowse link
G IFNG interferon gamma decreases expression
multiple interactions		 ISO Estriol results in decreased expression of IFNG protein
Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]		 CTD PMID:11063824 PMID:21317386 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IGF1 insulin like growth factor 1 increases expression EXP Estriol results in increased expression of IGF1 mRNA CTD PMID:15969240 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 decreases expression EXP Estriol results in decreased expression of IGFBP5 mRNA CTD PMID:15159206 NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549 		JBrowse link
G IL10 interleukin 10 increases expression ISO Estriol results in increased expression of IL10 mRNA CTD PMID:21317386 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A increases expression ISO Estriol results in increased expression of IL12A mRNA CTD PMID:21317386 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B decreases expression ISO Estriol results in decreased expression of IL12B mRNA CTD PMID:21317386 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL1A interleukin 1 alpha decreases expression EXP Estriol results in decreased expression of IL1A mRNA CTD PMID:10731640 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL23A interleukin 23 subunit alpha decreases expression ISO Estriol results in decreased expression of IL23A mRNA CTD PMID:21317386 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL4 interleukin 4 increases expression ISO Estriol results in increased expression of IL4 protein CTD PMID:21317386 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions		 EXP
ISO		 Estriol results in decreased expression of IL6 mRNA
Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tamoxifen inhibits the reaction [Estriol affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]		 CTD PMID:8979148 PMID:10731640 PMID:21317386 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INHBB inhibin subunit beta B increases expression ISO Estriol results in increased expression of INHBB mRNA CTD PMID:25575267 NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803 		JBrowse link
G IP6K2 inositol hexakisphosphate kinase 2 decreases expression ISO Estriol results in decreased expression of IP6K2 mRNA CTD PMID:25575267 NCBI chr 3:48,688,003...48,717,221
Ensembl chr 3:48,688,003...48,740,353 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Estriol results in increased expression of JUN mRNA CTD PMID:2118345 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G LPAR4 lysophosphatidic acid receptor 4 decreases expression ISO Estriol results in decreased expression of LPAR4 mRNA CTD PMID:25575267 NCBI chr  X:78,747,720...78,758,714
Ensembl chr  X:78,747,709...78,758,714 		JBrowse link
G LSM10 LSM10, U7 small nuclear RNA associated decreases expression ISO Estriol results in decreased expression of LSM10 mRNA CTD PMID:25575267 NCBI chr 1:36,393,436...36,397,908
Ensembl chr 1:36,391,238...36,397,908 		JBrowse link
G MAK16 MAK16 homolog increases expression ISO Estriol results in increased expression of RBM13 mRNA CTD PMID:25575267 NCBI chr 8:33,485,182...33,501,262
Ensembl chr 8:33,485,182...33,501,262 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 increases expression ISO Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 ISO 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]
Estriol affects the phosphorylation of MAPK1 protein
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
affects phosphorylation		 ISO 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]
Estriol affects the phosphorylation of MAPK3 protein
4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression ISO Estriol results in increased expression of MYC mRNA CTD PMID:2118345 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase increases expression
multiple interactions		 ISO Estriol results in increased expression of NAMPT mRNA
[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]		 CTD PMID:20004694 NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Estriol results in decreased expression of NOS2 mRNA		 CTD PMID:11063824 PMID:21317386 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP Estriol results in increased expression of NOS3 mRNA; Estriol results in increased expression of NOS3 protein CTD PMID:12547825 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NPPC natriuretic peptide C increases expression ISO Estriol results in increased expression of NPPC protein CTD PMID:9435603 NCBI chr 2:231,921,809...231,926,396
Ensembl chr 2:231,921,809...231,926,396 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP Estriol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NUP50 nucleoporin 50 increases expression ISO Estriol results in increased expression of NUP50 mRNA CTD PMID:25575267 NCBI chr22:45,163,925...45,188,017
Ensembl chr22:45,163,925...45,188,017 		JBrowse link
G PDCD1LG2 programmed cell death 1 ligand 2 increases expression ISO Estriol results in increased expression of PDCD1LG2 protein CTD PMID:21317386 NCBI chr 9:5,510,531...5,571,282
Ensembl chr 9:5,510,531...5,571,282 		JBrowse link
G PDE12 phosphodiesterase 12 increases expression ISO Estriol results in increased expression of PDE12 mRNA CTD PMID:25575267 NCBI chr 3:57,556,274...57,656,495
Ensembl chr 3:57,556,274...57,656,480 		JBrowse link
G PDGFA platelet derived growth factor subunit A decreases expression EXP Estriol results in decreased expression of PDGFA mRNA CTD PMID:10731640 NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296 		JBrowse link
G PDZK1 PDZ domain containing 1 increases expression EXP Estriol results in increased expression of PDZK1 mRNA CTD PMID:14605097 PMID:15159206 NCBI chr 1:145,670,852...145,707,400
Ensembl chr 1:145,670,852...145,708,148 		JBrowse link
G PGR progesterone receptor increases expression EXP Estriol results in increased expression of PGR mRNA CTD PMID:19820872 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 decreases expression ISO Estriol results in decreased expression of PIK3IP1 mRNA CTD PMID:25575267 NCBI chr22:31,281,593...31,292,534
Ensembl chr22:31,281,594...31,292,534 		JBrowse link
G POLG2 DNA polymerase gamma 2, accessory subunit decreases expression ISO Estriol results in decreased expression of POLG2 mRNA CTD PMID:25575267 NCBI chr17:64,477,785...64,497,054
Ensembl chr17:64,477,785...64,497,054 		JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B increases expression ISO Estriol results in increased expression of PPP1R15B mRNA CTD PMID:25575267 NCBI chr 1:204,395,826...204,411,817
Ensembl chr 1:204,396,492...204,411,887 		JBrowse link
G PPP4R1 protein phosphatase 4 regulatory subunit 1 increases expression ISO Estriol results in increased expression of PPP4R1 mRNA CTD PMID:25575267 NCBI chr18:9,546,794...9,617,199
Ensembl chr18:9,546,791...9,615,240 		JBrowse link
G PRL prolactin increases expression
increases secretion
multiple interactions		 ISO Estriol results in increased expression of PRL mRNA; Estriol results in increased expression of PRL protein
Estriol results in increased secretion of PRL protein
4-ethylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; bisphenol A affects the reaction [Estriol results in increased secretion of PRL protein]
Estriol promotes the reaction [Estradiol results in increased expression of PRL mRNA]		 CTD PMID:3780563 PMID:3996322 PMID:7306549 PMID:20950447 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PRRX2 paired related homeobox 2 increases expression ISO Estriol results in increased expression of PRRX2 mRNA CTD PMID:25575267 NCBI chr 9:129,665,647...129,722,674
Ensembl chr 9:129,665,647...129,722,674 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Estriol inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:12547825 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RRP1B ribosomal RNA processing 1B increases expression ISO Estriol results in increased expression of RRP1B mRNA CTD PMID:25575267 NCBI chr21:43,659,560...43,696,079
Ensembl chr21:43,659,560...43,696,079 		JBrowse link
G SDC3 syndecan 3 increases expression ISO Estriol results in increased expression of SDC3 mRNA CTD PMID:11024013 NCBI chr 1:30,869,466...30,909,735
Ensembl chr 1:30,869,466...30,908,758 		JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Estriol results in decreased expression of SELENBP1 mRNA CTD PMID:15159206 NCBI chr 1:151,364,304...151,372,705
Ensembl chr 1:151,364,304...151,372,707 		JBrowse link
G SHBG sex hormone binding globulin affects binding EXP Estriol binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G SIRT3 sirtuin 3 decreases expression ISO Estriol results in decreased expression of SIRT3 mRNA CTD PMID:25575267 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SLC12A2 solute carrier family 12 member 2 decreases expression EXP Estriol results in decreased expression of SLC12A2 mRNA CTD PMID:15159206 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Estriol results in increased expression of SLC7A11 mRNA CTD PMID:15159206 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SLC7A6 solute carrier family 7 member 6 increases expression ISO Estriol results in increased expression of SLC7A6 mRNA CTD PMID:25575267 NCBI chr16:68,264,526...68,301,819
Ensembl chr16:68,264,516...68,301,823 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression ISO Estriol results in increased expression of SOCS3 mRNA CTD PMID:25575267 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A increases expression ISO Estriol results in increased expression of STAT5A mRNA CTD PMID:25575267 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 decreases activity EXP Estriol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G SYNPO synaptopodin increases expression ISO Estriol results in increased expression of SYNPO mRNA CTD PMID:25575267 NCBI chr 5:150,586,010...150,659,207
Ensembl chr 5:150,601,080...150,659,207 		JBrowse link
G TBX19 T-box transcription factor 19 decreases abundance EXP TBX19 gene mutant form results in decreased abundance of Estriol CTD PMID:16390921 NCBI chr 1:168,280,877...168,314,426
Ensembl chr 1:168,280,877...168,314,426 		JBrowse link
G TFF1 trefoil factor 1 increases expression
multiple interactions		 EXP Estriol results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estriol results in increased expression of TFF1 mRNA]		 CTD PMID:22562034 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression ISO Estriol results in increased expression of TGFB1 mRNA CTD PMID:21317386 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THRA thyroid hormone receptor alpha decreases expression ISO Estriol results in decreased expression of THRA mRNA CTD PMID:25575267 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G TMEM183A transmembrane protein 183A increases expression ISO Estriol results in increased expression of TMEM183A mRNA CTD PMID:25575267 NCBI chr 1:203,007,374...203,024,848
Ensembl chr 1:203,007,374...203,024,848 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Estriol inhibits the reaction [TNF protein affects the localization of RELA protein]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]
estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver and protein in serum]
Estriol affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Estriol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tamoxifen inhibits the reaction [Estriol promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]		 CTD
RGD		 PMID:8979148 PMID:11063824 PMID:12547825 PMID:9575848 RGD:15017096 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TXNIP thioredoxin interacting protein decreases expression ISO Estriol results in decreased expression of TXNIP mRNA CTD PMID:25575267 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579 		JBrowse link
G TYR tyrosinase multiple interactions ISO Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
G UBE2F ubiquitin conjugating enzyme E2 F (putative) increases expression ISO Estriol results in increased expression of UBE2F mRNA CTD PMID:25575267 NCBI chr 2:237,967,014...238,042,782
Ensembl chr 2:237,966,827...238,042,782 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of Estriol; UGT1A1 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of Estriol; UGT1A10 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of Estriol; UGT1A3 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Estriol; UGT1A7 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of Estriol; UGT1A8 protein results in increased glucuronidation of Estriol analog CTD PMID:15117964 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT2B11 UDP glucuronosyltransferase family 2 member B11 increases glucuronidation EXP UGT2B11 protein results in increased glucuronidation of Estriol CTD PMID:8333863 NCBI chr 4:69,199,951...69,224,984
Ensembl chr 4:69,199,951...69,214,748 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases glucuronidation
increases metabolic processing		 EXP UGT2B15 protein results in increased glucuronidation of Estriol
UGT2B15 protein results in increased metabolism of Estriol		 CTD PMID:2116769 PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 increases glucuronidation EXP UGT2B4 protein results in increased glucuronidation of Estriol CTD PMID:1909626 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation EXP UGT2B7 protein alternative form results in increased glucuronidation of Estriol; UGT2B7 protein results in increased glucuronidation of Estriol CTD PMID:8423545 PMID:8517101 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
G UTP6 UTP6 small subunit processome component increases expression ISO Estriol results in increased expression of UTP6 mRNA CTD PMID:25575267 NCBI chr17:31,860,904...31,901,708
Ensembl chr17:31,860,904...31,901,708 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Estriol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:12547825 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VDR vitamin D receptor increases expression EXP Estriol results in increased expression of VDR mRNA CTD PMID:14992164 PMID:15775415 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression ISO Estriol results in increased expression of VEGFA mRNA alternative form CTD PMID:8344219 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VTCN1 V-set domain containing T cell activation inhibitor 1 increases expression ISO Estriol results in increased expression of VTCN1 protein CTD PMID:21317386 NCBI chr 1:117,143,587...117,210,927
Ensembl chr 1:117,143,587...117,210,960 		JBrowse link
G WARS1 tryptophanyl-tRNA synthetase 1 increases expression EXP Estriol results in increased expression of WARS1 mRNA CTD PMID:15159206 NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805 		JBrowse link
G ZNF688 zinc finger protein 688 decreases expression ISO Estriol results in decreased expression of ZFP688 mRNA CTD PMID:25575267 NCBI chr16:30,569,726...30,579,951
Ensembl chr16:30,569,672...30,572,734 		JBrowse link
estriol 16-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions ISO estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KL klotho multiple interactions
increases hydrolysis		 ISO estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide		 CTD PMID:14701853 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26559
    role 26385
      biological role 26364
        molecular messenger 20313
          hormone 19942
            sex hormone 19765
              estrogen 19557
                estriol 131
                  3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                  6-ketoestriol 0
                  estriol 16-O-(beta-D-glucuronide) 1
                  estriol 3-O-(beta-D-glucuronide) 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 26559
    subatomic particle 26535
      composite particle 26535
        hadron 26535
          baryon 26535
            nucleon 26535
              atomic nucleus 26535
                atom 26535
                  main group element atom 26283
                    p-block element atom 26283
                      carbon group element atom 25735
                        carbon atom 25698
                          organic molecular entity 25698
                            organic molecule 25445
                              organic cyclic compound 24490
                                organic polycyclic compound 19025
                                  steroid 16321
                                    hydroxy steroid 16075
                                      16-hydroxy steroid 164
                                        16alpha-hydroxy steroid 160
                                          estriol 131
                                            3-(allyloxy)estra-1,3,5(10)-triene-16alpha,17beta-diol 0
                                            6-ketoestriol 0
                                            estriol 16-O-(beta-D-glucuronide) 1
                                            estriol 3-O-(beta-D-glucuronide) 1
paths to the root