CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phenylhydrazine
Accession: CHEBI:27924
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Definition: A phenylhydrazine that is the monophenyl derivative of hydrazine.
Synonyms: related_synonym: 1-PHENYLHYDRAZINE; Formula=C6H8N2; Hydrazinobenzene; InChI=1S/C6H8N2/c7-8-6-4-2-1-3-5-6/h1-5,8H,7H2; InChIKey=HKOOXMFOFWEVGF-UHFFFAOYSA-N; PhNHNH2; Phenyldiazane; Phenylhydrazin; SMILES=NNc1ccccc1; hydrazobenzene; monophenylhydrazine
alt_id: CHEBI:25995; CHEBI:44985; CHEBI:8099
xref: CAS:100-63-0; Gmelin:26849; KEGG:C02304
xref_mesh: MESH:C030299
xref: MetaCyc:PHENYLHYDRAZINE; PDBeChem:PHZ; PMID:19627281; PMID:20585853; PMID:7144447; Reaxys:606080; Wikipedia:Phenylhydrazine
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1700009N14Rikl
RIKEN cDNA 1700009N14 gene like
increases expression
EXP
phenylhydrazine results in increased expression of 1700009N14RIKL mRNA
CTD
PMID:17698508
NCBI chr 5:54,456,005...54,457,381
Ensembl chr 5:54,455,893...54,457,677
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Ahsp
alpha hemoglobin stabilizing protein
increases expression
EXP
phenylhydrazine results in increased expression of AHSP mRNA
CTD
PMID:17082564
NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506
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Akap10
A-kinase anchoring protein 10
increases expression
EXP
phenylhydrazine results in increased expression of AKAP10 mRNA
CTD
PMID:17082564
NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769
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Alas2
5'-aminolevulinate synthase 2
increases expression increases activity multiple interactions
EXP
phenylhydrazine results in increased expression of ALAS2 mRNA phenylhydrazine results in increased activity of ALAS2 protein Methotrexate inhibits the reaction [phenylhydrazine results in increased activity of ALAS2 protein]
CTD
PMID:2841940 PMID:17082564
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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Alb
albumin
multiple interactions
EXP
Folic Acid inhibits the reaction [phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]]; phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]
CTD
PMID:33788065
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Cbs
cystathionine beta synthase
decreases activity multiple interactions
EXP
phenylhydrazine results in decreased activity of CBS protein Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of CBS protein]
CTD
PMID:33788065
NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
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Ccnd1
cyclin D1
multiple interactions decreases expression affects expression
ISO
Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased expression of CCND1 mRNA]; royal jelly inhibits the reaction [phenylhydrazine affects the expression of CCND1 mRNA]
CTD
PMID:30140404 PMID:35099105
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cd7
Cd7 molecule
decreases expression
EXP
phenylhydrazine results in decreased expression of CD7 mRNA
CTD
PMID:17698508
NCBI chr10:106,304,046...106,306,963
Ensembl chr10:106,304,056...106,306,967
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Cd8a
CD8 subunit alpha
decreases expression
EXP
phenylhydrazine results in decreased expression of CD8A mRNA
CTD
PMID:17698508
NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
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Ceacam4
CEA cell adhesion molecule 4
increases expression
EXP
phenylhydrazine results in increased expression of CEACAM10 mRNA
CTD
PMID:17082564
NCBI chr 1:80,376,667...80,382,943
Ensembl chr 1:80,376,648...80,382,915
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Chchd6
coiled-coil-helix-coiled-coil-helix domain containing 6
increases expression
EXP
phenylhydrazine results in increased expression of CHCHD6 mRNA
CTD
PMID:17698508
NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
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Creg1
cellular repressor of E1A-stimulated genes 1
increases expression
EXP
phenylhydrazine results in increased expression of CREG1 mRNA
CTD
PMID:17698508
NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
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Ctsb
cathepsin B
increases expression
EXP
phenylhydrazine results in increased expression of CTSB mRNA
CTD
PMID:17698508
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Ctsd
cathepsin D
increases expression
EXP
phenylhydrazine results in increased expression of CTSD mRNA
CTD
PMID:17698508
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cul4a
cullin 4A
affects response to substance
ISO
CUL4A protein affects the susceptibility to phenylhydrazine
CTD
PMID:16467204
NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
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Cyp2c22
cytochrome P450, family 2, subfamily c, polypeptide 22
decreases expression
EXP
phenylhydrazine results in decreased expression of CYP2C22 mRNA
CTD
PMID:17082564
NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
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Dut
deoxyuridine triphosphatase
increases activity multiple interactions
EXP
phenylhydrazine results in increased activity of DUT protein Methotrexate inhibits the reaction [phenylhydrazine results in increased activity of DUT protein]
CTD
PMID:2841940
NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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Emb
embigin
increases expression
EXP
phenylhydrazine results in increased expression of EMB mRNA
CTD
PMID:17082564
NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
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Epo
erythropoietin
increases expression
EXP
phenylhydrazine results in increased expression of EPO mRNA
CTD
PMID:22908232
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Epor
erythropoietin receptor
affects response to substance
ISO
EPOR gene mutant form affects the susceptibility to phenylhydrazine
CTD
PMID:16511603
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
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Fabp4
fatty acid binding protein 4
increases expression
EXP
phenylhydrazine results in increased expression of FABP4 mRNA
CTD
PMID:17698508
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Fabp5
fatty acid binding protein 5
increases expression
EXP
phenylhydrazine results in increased expression of FABP5 mRNA
CTD
PMID:17698508
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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Fcgr2b
Fc gamma receptor 2B
increases expression
EXP
phenylhydrazine results in increased expression of FCGR2B mRNA
CTD
PMID:17082564
NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
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Flg
filaggrin
increases expression
EXP
phenylhydrazine results in increased expression of FLG mRNA
CTD
PMID:17082564
NCBI chr 2:178,884,793...178,912,986
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Frem2
FRAS1 related extracellular matrix 2
decreases expression
EXP
phenylhydrazine results in decreased expression of FREM2 mRNA
CTD
PMID:17082564
NCBI chr 2:137,602,784...137,740,785
Ensembl chr 2:137,602,784...137,740,785
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Ftl1
ferritin light chain 1
increases expression
EXP
phenylhydrazine results in increased expression of FTL1 mRNA
CTD
PMID:17698508
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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G0s2
G0/G1switch 2
decreases expression
EXP
phenylhydrazine results in decreased expression of G0S2 mRNA
CTD
PMID:17082564
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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Gcgr
glucagon receptor
increases expression
EXP
phenylhydrazine results in increased expression of GCGR mRNA
CTD
PMID:17698508
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
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Gfra1
GDNF family receptor alpha 1
increases expression
EXP
phenylhydrazine results in increased expression of GFRA1 mRNA
CTD
PMID:17698508
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Gpnmb
glycoprotein nmb
increases expression
EXP
phenylhydrazine results in increased expression of GPNMB mRNA
CTD
PMID:17082564 PMID:17698508
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Gpt
glutamic--pyruvic transaminase
multiple interactions increases activity
ISO EXP
SESN2 protein inhibits the reaction [phenylhydrazine results in increased activity of GPT protein] Folic Acid inhibits the reaction [phenylhydrazine results in increased activity of GPT protein]
CTD
PMID:31323261 PMID:33788065
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx4
glutathione peroxidase 4
decreases expression
ISO
phenylhydrazine results in decreased expression of GPX4 protein
CTD
PMID:31323261
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Gsn
gelsolin
affects response to substance
ISO
GSN protein affects the susceptibility to phenylhydrazine
CTD
PMID:22271892
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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Gzmk
granzyme K
decreases expression
EXP
phenylhydrazine results in decreased expression of GZMK mRNA
CTD
PMID:17698508
NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894
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Hba-a1
hemoglobin alpha, adult chain 1
increases expression
EXP
phenylhydrazine results in increased expression of HBA-A1 mRNA
CTD
PMID:17082564
NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392
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Hbe2
hemoglobin, epsilon 2
increases expression
EXP
phenylhydrazine results in increased expression of HBE2 mRNA
CTD
PMID:17082564
NCBI chr 1:158,279,285...158,280,913
Ensembl chr 1:158,279,285...158,280,913
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Hmox1
heme oxygenase 1
increases expression
EXP
phenylhydrazine results in increased expression of HMOX1 mRNA; phenylhydrazine results in increased expression of HMOX1 protein
CTD
PMID:17082564 PMID:17698508
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Lbp
lipopolysaccharide binding protein
increases expression
EXP
phenylhydrazine results in increased expression of LBP mRNA
CTD
PMID:17082564
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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Lgals3
galectin 3
increases expression
EXP
phenylhydrazine results in increased expression of LGALS3 mRNA
CTD
PMID:17082564 PMID:17698508
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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Lgmn
legumain
increases expression
EXP
phenylhydrazine results in increased expression of LGMN mRNA
CTD
PMID:17698508
NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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Mt1
metallothionein 1
increases expression
EXP
phenylhydrazine results in increased expression of MT1A mRNA
CTD
PMID:17082564
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mthfr
methylenetetrahydrofolate reductase
multiple interactions decreases activity
EXP
Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTHFR protein]
CTD
PMID:33788065
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
decreases activity multiple interactions
EXP
phenylhydrazine results in decreased activity of MTR protein Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTR protein]
CTD
PMID:33788065
NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions decreases expression
ISO
Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA]; royal jelly inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA]
CTD
PMID:30140404 PMID:35099105
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nat2
N-acetyltransferase 2
increases acetylation
ISO
NAT2 protein results in increased acetylation of phenylhydrazine
CTD
PMID:15627487
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Nck2
NCK adaptor protein 2
decreases expression
EXP
phenylhydrazine results in decreased expression of NCK2 mRNA
CTD
PMID:17082564
NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
phenylhydrazine results in increased activity of NFE2L2 protein
CTD
PMID:30114225 PMID:30203046
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nppb
natriuretic peptide B
multiple interactions increases expression
EXP
Doxorubicin inhibits the reaction [phenylhydrazine results in increased expression of NPPB mRNA]
CTD
PMID:22908232
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Npy
neuropeptide Y
increases expression
EXP
phenylhydrazine results in increased expression of NPY mRNA
CTD
PMID:17082564
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression
ISO
phenylhydrazine results in increased expression of NR1I3 mRNA
CTD
PMID:25949234
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Orc1
origin recognition complex, subunit 1
increases expression
EXP
phenylhydrazine results in increased expression of ORC1 mRNA
CTD
PMID:17698508
NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
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Plscr1
phospholipid scramblase 1
increases expression
EXP
phenylhydrazine results in increased expression of PLSCR1 mRNA
CTD
PMID:17082564
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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Psmd6
proteasome 26S subunit, non-ATPase 6
increases expression
EXP
phenylhydrazine results in increased expression of PSMD6 mRNA
CTD
PMID:17082564
NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein]; SESN2 protein inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein]
CTD
PMID:30626086 PMID:31323261
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
increases expression
EXP
phenylhydrazine results in increased expression of PTPMT1 mRNA
CTD
PMID:17698508
NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427
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Rhd
Rh blood group, D antigen
increases expression
EXP
phenylhydrazine results in increased expression of RHD mRNA
CTD
PMID:17082564
NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715
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Ripk3
receptor-interacting serine-threonine kinase 3
increases expression
EXP
phenylhydrazine results in increased expression of RIPK3 mRNA
CTD
PMID:17082564
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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RT1-Bb
RT1 class II, locus Bb
decreases expression
EXP
phenylhydrazine results in decreased expression of RT1-BB mRNA
CTD
PMID:17698508
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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S100a8
S100 calcium binding protein A8
increases expression
EXP
phenylhydrazine results in increased expression of S100A8 mRNA
CTD
PMID:17082564
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9
S100 calcium binding protein A9
increases expression
EXP
phenylhydrazine results in increased expression of S100A9 mRNA
CTD
PMID:17082564
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Serpina3n
serpin family A member 3N
increases expression
EXP
phenylhydrazine results in increased expression of SERPINA3N mRNA
CTD
PMID:17698508
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Sesn2
sestrin 2
multiple interactions
ISO
SESN2 protein inhibits the reaction [phenylhydrazine results in increased activity of GPT protein]; SESN2 protein inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein]
CTD
PMID:31323261
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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Slc39a14
solute carrier family 39 member 14
increases expression
EXP
phenylhydrazine results in increased expression of SLC39A14 mRNA
CTD
PMID:17082564
NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
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Slc40a1
solute carrier family 40 member 1
increases expression
EXP
phenylhydrazine results in increased expression of SLC40A1 mRNA
CTD
PMID:17082564
NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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Spink1
serine peptidase inhibitor, Kazal type 1
increases expression
EXP
phenylhydrazine results in increased expression of SPINK1 mRNA
CTD
PMID:17082564
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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Spmip7
sperm microtubule inner protein 7
increases expression
EXP
phenylhydrazine results in increased expression of SPMIP7 mRNA
CTD
PMID:17698508
NCBI chr14:86,030,427...86,085,644
Ensembl chr14:86,030,655...86,085,644
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Tk1
thymidine kinase 1
increases activity multiple interactions
EXP
phenylhydrazine results in increased activity of TK1 protein Methotrexate inhibits the reaction [phenylhydrazine results in increased activity of TK1 protein]
CTD
PMID:2841940
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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Tnf
tumor necrosis factor
multiple interactions
ISO
phenylhydrazine analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
CTD
PMID:26549477
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf17
TNF receptor superfamily member 17
decreases expression
EXP
phenylhydrazine results in decreased expression of TNFRSF17 mRNA
CTD
PMID:17698508
NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788
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Trib3
tribbles pseudokinase 3
increases expression
EXP
phenylhydrazine results in increased expression of TRIB3 mRNA
CTD
PMID:17082564
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Ucp2
uncoupling protein 2
affects response to substance
ISO
UCP2 protein affects the susceptibility to phenylhydrazine
CTD
PMID:18687678
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Vcam1
vascular cell adhesion molecule 1
increases expression
EXP
phenylhydrazine results in increased expression of VCAM1 mRNA
CTD
PMID:17082564
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vegfa
vascular endothelial growth factor A
multiple interactions increases expression
EXP
Doxorubicin inhibits the reaction [phenylhydrazine results in increased expression of VEGFA mRNA]
CTD
PMID:22908232
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Zbtb44
zinc finger and BTB domain containing 44
decreases expression
EXP
phenylhydrazine results in decreased expression of ZBTB44 mRNA
CTD
PMID:17082564
NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163
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