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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cisplatin
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Accession:CHEBI:27899 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Synonyms:exact_synonym: (SP-4-2)-diamminedichloridoplatinum;   (SP-4-2)-diamminedichloroplatinum;   cis-diamminedichloridoplatinum(II)
 related_synonym: Briplatin;   CDDP;   Cismaplat;   Formula=Cl2H6N2Pt;   Formula=H6Cl2N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   Lederplatin;   Neoplatin;   Peyrone's chloride;   Peyrone's salt;   Platamine;   Platinex;   Platinol;   Randa;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   [PtCl2(NH3)2];   cis-DDP;   cis-Diamminedichloroplatinum(II);   cis-[PtCl2(NH3)2];   cis-diamminedichloroplatinum;   cis-diammineplatinum(II) dichloride;   cis-dichlorodiammineplatinum(II);   cis-platin;   cisplatine;   cisplatino;   cisplatinum
 alt_id: CHEBI:23314;   CHEBI:3722
 xref: CAS:15663-27-1;   DrugBank:DB00515;   Gmelin:2519;   HMDB:HMDB0014656;   KEGG:C06911;   KEGG:D00275
 xref_mesh: MESH:D002945
 xref: MetaCyc:CPD0-1392;   MolBase:25;   PMID:10883661;   PMID:12537968;   PMID:12831510;   PMID:12935404;   PMID:16327988;   PMID:18472761;   PMID:1855275;   PMID:23554447;   PMID:23604226;   PMID:23651576;   PMID:28494534;   Patent:DE2318020;   Patent:DE2329485;   Reaxys:11324567;   Wikipedia:Cisplatin



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    Path 1
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      CHEBI ontology 26482
        role 26303
          biological role 26282
            biochemical role 25491
              ferroptosis inducer 16876
                cisplatin 8166
    Path 2
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      CHEBI ontology 26482
        subatomic particle 26458
          composite particle 26458
            hadron 26458
              baryon 26458
                nucleon 26458
                  atomic nucleus 26458
                    atom 26458
                      metal atom 21640
                        transition element atom 19987
                          d-block element atom 19982
                            nickel group element atom 11161
                              platinum 9231
                                platinum molecular entity 9231
                                  platinum coordination entity 9231
                                    diamminedichloroplatinum 8166
                                      cisplatin 8166
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