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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:androstane-3,17-diol
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Accession:CHEBI:27727 term browser browse the term
Definition:A 17-hydroxy steroid that has formula C19H32O2.
Synonyms:related_synonym: Androstanediol;   Formula=C19H32O2;   InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12?,13?,14-,15-,16-,17?,18-,19-/m0/s1;   InChIKey=CBMYJHIOYJEBSB-CAHXEBCQSA-N;   SMILES=[H][C@@]12CCC3CC(O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(O)CC[C@@]21[H]
 alt_id: CHEBI:22544;   CHEBI:2713
 xref: Beilstein:9220448;   CAS:25126-76-5;   KEGG:C07632
 xref_mesh: MESH:D015113


show annotations for term's descendants           Sort by:
androstane-3,17-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:11158055 PMID:17170221 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Aqp9 aquaporin 9 increases expression EXP Androstane-3,17-diol results in increased expression of AQP9 mRNA; Androstane-3,17-diol results in increased expression of AQP9 protein CTD PMID:17026757 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Androstane-3,17-diol results in increased expression of CYP11A1 mRNA CTD PMID:21273442 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Androstane-3,17-diol results in increased expression of CYP19A1 mRNA CTD PMID:21273442 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Androstane-3,17-diol results in decreased expression of CYP7B1 mRNA CTD PMID:16630558 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein; Androstane-3,17-diol binds to and results in increased activity of ESR1 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein] CTD PMID:17003281 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
affects binding		 ISO
EXP		 Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein; Androstane-3,17-diol binds to and results in increased activity of ESR2 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR2 protein]
Androstane-3,17-diol results in increased activity of ESR2 protein
Androstane-3,17-diol inhibits the reaction [Estradiol binds to ESR2 protein]
Androstane-3,17-diol binds to ESR2 protein		 CTD PMID:8650195 PMID:16452668 PMID:17003281 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects binding
multiple interactions		 ISO Androstane-3,17-diol binds to HSD11B1 protein
[Androstane-3,17-diol co-treated with NAD] binds to HSD11B1 protein		 CTD PMID:25526675 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [Androstane-3,17-diol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases chemical synthesis ISO HSD17B12 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:17641292 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases chemical synthesis
increases secretion		 EXP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [LHB protein results in increased secretion of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol] CTD PMID:24451217 PMID:31184881 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein; arsenite inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; bisphenol A inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; butyl phosphorotrithioate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Chlorpyrifos inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Corticosterone inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; cypermethrin inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Diethylhexyl Phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Methoxychlor inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; nonylphenol inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Parathion inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein] CTD PMID:18832183 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression ISO Androstane-3,17-diol affects the expression of PRKACB mRNA alternative form; Androstane-3,17-diol affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Rdh16 retinol dehydrogenase 16 increases metabolic processing
multiple interactions		 EXP RDH16 protein results in increased metabolism of Androstane-3,17-diol
[RDH16 protein results in increased metabolism of Androstane-3,17-diol] which results in increased chemical synthesis of Dihydrotestosterone		 CTD PMID:28535922 NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases metabolic processing ISO UGT2B17 protein results in increased metabolism of Androstane-3,17-diol CTD PMID:8798464 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
5alpha-androstane-3alpha,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding EXP 3alpha-androstanediol binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
5alpha-androstane-3beta,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding EXP 3beta-androstanediol binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        polyatomic entity 19824
          heteroatomic molecular entity 19781
            hydroxides 19341
              organic hydroxy compound 18951
                hydroxy steroid 14466
                  3-hydroxy steroid 12808
                    androstane-3,17-diol 15
                      5alpha-androstane-3beta,17alpha-diol + 0
                      5alpha-androstane-3beta,17beta-diol + 1
                      5beta-androstane-3beta,17beta-diol 0
                      androstane-3alpha,17beta-diol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic polycyclic compound 17286
                                  steroid 14717
                                    steroid fundamental parent 14511
                                      androstane 6054
                                        androstanoid 4826
                                          androstane-3,17-diol 15
                                            5alpha-androstane-3beta,17alpha-diol + 0
                                            5alpha-androstane-3beta,17beta-diol + 1
                                            5beta-androstane-3beta,17beta-diol 0
                                            androstane-3alpha,17beta-diol + 1
paths to the root