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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-aminosalicylic acid
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Accession:CHEBI:27565 term browser browse the term
Definition:An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.
Synonyms:exact_synonym: 4-amino-2-hydroxybenzoic acid
 related_synonym: 2-HYDROXY-4-AMINOBENZOIC ACID;   4-Aminosalicylate;   Aminosalicylic acid;   Formula=C7H7NO3;   InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11);   InChIKey=WUBBRNOQWQTFEX-UHFFFAOYSA-N;   PAS;   Para-amino salicylic acid;   Paser;   SMILES=Nc1ccc(C(O)=O)c(O)c1;   p-aminosalicylic acid
 alt_id: CHEBI:1789;   CHEBI:20320;   CHEBI:41152
 xref: CAS:65-49-6;   DrugBank:DB00233;   Drug_Central:2050;   Gmelin:306153;   HMDB:HMDB0014378;   KEGG:C02518;   KEGG:D00162;   LINCS:LSM-5862
 xref_mesh: MESH:D010131
 xref: PDBeChem:BHA;   PMID:11621575;   PMID:1650428;   PMID:23118010;   PMID:24663015;   PMID:25050392;   PMID:25421465;   PMID:25605031;   PMID:25963985;   PMID:26004847;   PMID:26033719;   PMID:26277036;   PMID:26596566;   PMID:26848874;   PMID:27021327;   PMID:27491492;   PMID:27617928;   PMID:27671064;   PMID:28011126;   PMID:28223391;   PMID:28394286;   PMID:28408267;   PMID:28567674;   PMID:28651968;   PMID:28717039;   PMID:28812999;   Patent:DE50835;   Patent:US2844625;   Patent:US427564;   Reaxys:473071;   Wikipedia:Aminosalicylic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:137598


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4-aminosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO Aminosalicylic Acid results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Ereg epiregulin increases expression ISO Aminosalicylic Acid results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Il24 interleukin 24 increases expression ISO Aminosalicylic Acid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Aminosalicylic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Aminosalicylic Acid CTD PMID:15627487 PMID:16003948 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid CTD PMID:19248797 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Aminosalicylic Acid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Aminosalicylic Acid results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Aminosalicylic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        antimicrobial agent 18250
          antifungal agent 17164
            salicylic acid 1567
              4-aminosalicylic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      aromatic carboxylic acid 12689
                                        benzoic acids 12666
                                          benzoic acid 5504
                                            hydroxybenzoic acid 4979
                                              monohydroxybenzoic acid 2814
                                                salicylic acid 1567
                                                  4-aminosalicylic acid 9
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