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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prostaglandin J2
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Accession:CHEBI:27485 term browser browse the term
Definition:A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).
Synonyms:exact_synonym: (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid
 related_synonym: 9-Deoxy-delta-9-pgd2;   9-Deoxy-delta-9-prostaglandin D2;   Formula=C20H30O4;   InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1;   InChIKey=UQOQENZZLBSFKO-POPPZSFYSA-N;   PGJ2;   SMILES=CCCCC[C@H](O)\\C=C\\[C@@H]1[C@@H](C\\C=C/CCCC(O)=O)C=CC1=O
 alt_id: CHEBI:26332;   CHEBI:8521
 xref: CAS:60203-57-8;   HMDB:HMDB0002710;   KEGG:C05957;   LIPID_MAPS_instance:LMFA03010019
 xref_mesh: MESH:C037112
 xref: PMID:12213491;   Reaxys:8353080
 cyclic_relationship: is_conjugate_acid_of CHEBI:133396



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prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of ABCA1 mRNA CTD PMID:12595494 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [AKR1C3 protein results in decreased metabolism of Prostaglandin D2] which results in decreased chemical synthesis of 9-deoxy-delta-9-prostaglandin D2 CTD PMID:20036328 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol] CTD PMID:12595494 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases cleavage ISO 9-deoxy-delta-9-prostaglandin D2 results in increased cleavage of ARHGDIB protein CTD PMID:15843042 NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:171,554,140...171,573,068
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
9-deoxy-delta-9-prostaglandin D2 results in increased activity of CASP3 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein
CTD PMID:15843042 PMID:23973622 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased activity of CEBPB protein CTD PMID:15150131 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO 9-deoxy-delta-9-prostaglandin D2 results in decreased expression of CES1 mRNA CTD PMID:11409902 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [arsenite results in increased expression of CRYAB mRNA]; 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:9066782 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528
JBrowse link
G Ep300 E1A binding protein p300 decreases activity ISO 9-deoxy-delta-9-prostaglandin D2 results in decreased activity of EP300 protein CTD PMID:22141352 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC mRNA; 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC protein CTD PMID:18332871 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLM mRNA; 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLM protein CTD PMID:18332871 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression
ISO [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]
9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 mRNA; 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein
CTD PMID:14662774 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects metabolic processing ISO GSTA1 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2 CTD PMID:9084911 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
affects metabolic processing
increases expression
EXP
ISO
[9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]; [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased expression of GSTA2 mRNA; [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased expression of GSTA2 protein
GSTA2 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2
9-deoxy-delta-9-prostaglandin D2 results in increased expression of GSTA2 protein
CTD PMID:9084911 PMID:15150131 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2 CTD PMID:9084911 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 9-deoxy-delta-9-prostaglandin D2 results in increased expression of JUN protein modified form CTD PMID:11401521 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased activity of NFE2L2 protein CTD PMID:15150131 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of NR1H3 mRNA CTD PMID:12595494 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
9-deoxy-delta-9-prostaglandin D2 results in increased cleavage of PARP1 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein
CTD PMID:15843042 PMID:23973622 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
increases expression
multiple interactions
ISO
EXP
9-deoxy-delta-9-prostaglandin D2 results in increased activity of PPARG protein
9-deoxy-delta-9-prostaglandin D2 results in increased expression of PPARG mRNA
9-deoxy-delta-9-prostaglandin D2 promotes the reaction [PPARG protein alternative form results in decreased activity of SLC2A4 promoter]; [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]
9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein; [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of ABCA1 mRNA; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of NR1H3 mRNA; Ethanol inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased activity of PPARG protein]
CTD PMID:11343236 PMID:12595494 PMID:12777391 PMID:14512786 PMID:14662774 More... NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PTGDR protein; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:19,790,499...19,797,873
Ensembl chr15:19,790,499...19,797,873
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter] CTD PMID:15150131 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [PPARG protein alternative form results in decreased activity of SLC2A4 promoter] CTD PMID:12777391 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
JBrowse link
G Tg thyroglobulin multiple interactions
increases expression
ISO 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein]
9-deoxy-delta-9-prostaglandin D2 results in increased expression of TG protein
CTD PMID:11078701 NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein] CTD PMID:11078701 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984
JBrowse link
13,14-dihydro-Delta(12)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
EXP 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA
Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]
CTD PMID:22982731 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA] CTD PMID:22982731 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
JBrowse link
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases transport
affects glutathionylation
affects export
ISO [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
ABCC1 protein affects the glutathionylation of 15-deoxy-delta(12,14)-prostaglandin J2
ABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog
CTD PMID:14979731 PMID:21728338 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects export ISO ABCC3 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog CTD PMID:14979731 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACAA2 mRNA CTD PMID:34323617 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA CTD PMID:34323617 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Agt angiotensinogen multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2 CTD PMID:19997560 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of AKT1 protein CTD PMID:16611854 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BGLAP mRNA CTD PMID:12021203 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC2 protein CTD PMID:15498850 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC3 protein CTD PMID:15498850 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP3 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein
CTD PMID:11785780 PMID:15498850 PMID:16299251 PMID:23973622 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15498850 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:15498850 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] CTD PMID:12847270 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein] CTD PMID:15187150 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNA2 protein CTD PMID:15729575 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNB1 protein CTD PMID:15729575 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCND3 protein CTD PMID:15729575 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNE1 protein CTD PMID:15729575 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDK2 protein CTD PMID:15729575 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CDKN1A
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1A protein
CTD PMID:15254749 PMID:15729575 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1B protein CTD PMID:15729575 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CEBPA mRNA CTD PMID:12021203 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CFLAR protein CTD PMID:15498850 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein]
CTD PMID:15498850 PMID:22245093 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CIDEC mRNA CTD PMID:34323617 NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of COL1A1 mRNA CTD PMID:12021203 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]] CTD PMID:12604364 PMID:14998300 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA] CTD PMID:12468449 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Tretinoin] results in increased expression of FABP4 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FABP4 mRNA
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA
CTD PMID:9543393 PMID:12021203 PMID:16573735 PMID:34323617 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of FAS mRNA CTD PMID:16712844 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
CTD PMID:11457450 PMID:11687581 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein
CTD PMID:21728338 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GFAP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of GFAP mRNA
CTD PMID:15254749 PMID:15994020 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione] CTD PMID:14979731 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein
Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein]
CTD PMID:11600134 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA CTD PMID:21957481 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC2 mRNA CTD PMID:21957481 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC3 mRNA CTD PMID:21957481 NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects stability
increases expression
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the stability of HIF1A protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]
CTD PMID:17658243 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein; [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 protein
ochratoxin A inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]
CTD PMID:11078701 PMID:15618017 PMID:15994020 PMID:19136476 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
increases activity
ISO HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of HSF1 protein
CTD PMID:15618017 PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HSPB1 protein CTD PMID:16299251 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301
JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IFNG protein
CTD PMID:12847270 PMID:16844232 PMID:19888466 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA] CTD PMID:14998300 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases activity
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in decreased abundance of Prostaglandins]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of IL1B protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with IL1B protein] results in decreased secretion of IL1B protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1B protein
CTD PMID:11457450 PMID:12604364 PMID:14998300 PMID:15751073 PMID:16461118 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1RN mRNA CTD PMID:15751073 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:23688403 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:12604364 PMID:12847270 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACAA2 mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CIDEC mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PLIN1 mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARA mRNA CTD PMID:34323617 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA] CTD PMID:14625208 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:12847270 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]] CTD PMID:12847270 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein] CTD PMID:11457450 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Klf6 KLF transcription factor 6 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601
JBrowse link
G Lep leptin multiple interactions
increases secretion
ISO [Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased secretion of LEP protein
CTD PMID:11092516 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:19922793 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053
JBrowse link
G Lpl lipoprotein lipase increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of LPL mRNA CTD PMID:12021203 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein] CTD PMID:16324150 NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,641,862...83,685,545
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Cycloheximide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA] CTD PMID:19136476 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of MMP9 mRNA] CTD PMID:19997048 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein CTD PMID:16611854 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Nes nestin increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NES protein CTD PMID:15212945 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased activity of NFE2L2 protein; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and affects the localization of NFE2L2 protein; manganese chloride inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NFE2L2 protein]
CTD PMID:19136476 PMID:21728338 PMID:22245093 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased localization of NFKB1 protein
CTD PMID:11457450 PMID:16299251 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of NFKBIA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased degradation of NFKBIA protein]
CTD PMID:15498850 PMID:22245093 PMID:23688403 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS2 protein
CTD PMID:11457450 PMID:11890746 PMID:12847270 PMID:15684285 PMID:15994020 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS3 protein CTD PMID:11890746 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects activity
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the activity of NR3C1 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Dexamethasone binds to NR3C1 protein]
CTD PMID:15187150 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein] CTD PMID:22245093 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of PARP1 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein
CTD PMID:15498850 PMID:23973622 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PCK1 mRNA CTD PMID:9518257 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
JBrowse link
G Plin1 perilipin 1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PLIN1 mRNA CTD PMID:34323617 NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARA protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARA mRNA
CTD PMID:9013583 PMID:34323617 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARD protein CTD PMID:17341418 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
decreases expression
increases activity
multiple interactions
increases expression
decreases response to substance
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the expression of PPARG
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased expression of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in decreased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased localization of and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARG mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; MG 262 promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form]
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG protein
PPARG protein mutant form results in decreased susceptibility to 15-deoxy-delta(12,14)-prostaglandin J2
CTD PMID:9013583 PMID:10662598 PMID:11030710 PMID:12065695 PMID:12604364 More... NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:19,790,499...19,797,873
Ensembl chr15:19,790,499...19,797,873
JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD PMID:12721327 PMID:16256979 NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:216,995,629...217,022,393
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:17439952 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PTGS2
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA]
CTD PMID:11457450 PMID:12604364 PMID:15254749 PMID:19997048 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases phosphorylation EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of PTPN11 protein CTD PMID:12584205 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of and results in decreased phosphorylation of RAF1 protein CTD PMID:12083801 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RARB
CTD PMID:12839938 PMID:15254749 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride affects the localization of RELA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of RELA protein
CTD PMID:11457450 PMID:15498850 PMID:20174873 PMID:22245093 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of RIGI mRNA] CTD PMID:16303604 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein CTD PMID:16611854 NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of RUNX2 mRNA CTD PMID:12021203 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027
JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RXRA CTD PMID:15254749 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS1 mRNA CTD PMID:12584205 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS3 mRNA CTD PMID:12584205 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of SPP1 mRNA CTD PMID:12021203 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
CTD PMID:12584205 PMID:12847270 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
CTD PMID:12584205 PMID:12847270 PMID:19922793 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
decreases expression
ISO PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form] CTD PMID:16499875 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:9,034,108...9,038,905
JBrowse link
G Tg thyroglobulin multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TG protein
CTD PMID:11078701 NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases response to substance
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased susceptibility to TGFB1 protein
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [Alitretinoin results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; bisphenol A diglycidyl ether inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TGFB1 mRNA
CTD PMID:16611854 PMID:18278065 PMID:19429239 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Th tyrosine hydroxylase increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TH protein CTD PMID:15212945 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA
CTD PMID:20174873 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TNF protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:12604364 PMID:19888466 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein] CTD PMID:11078701 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420
JBrowse link
G Vim vimentin decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of VIM CTD PMID:15254749 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr 7:131,801,046...131,806,850
Ensembl chr 7:131,801,046...131,806,850
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of XIAP protein CTD PMID:15498850 PMID:16299251 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          carbon atom 20710
            organic molecular entity 20710
              olefinic compound 17359
                enone 10207
                  prostaglandins J 129
                    prostaglandin J2 129
                      (R)-PGJ2-S-glutathione conjugate 0
                      (S)-PGJ2-S-glutathione conjugate 0
                      13,14-dihydro-Delta(12)-prostaglandin J2 4
                      15-deoxy-Delta(12,14)-prostaglandin J2 + 113
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbon oxoacid 19157
                                    carboxylic acid 19154
                                      monocarboxylic acid 18301
                                        fatty acid 17002
                                          fatty acid derivative 9224
                                            icosanoid 471
                                              prostanoid 407
                                                prostaglandin 399
                                                  prostaglandins D 145
                                                    prostaglandin D2 145
                                                      prostaglandin J2 129
                                                        (R)-PGJ2-S-glutathione conjugate 0
                                                        (S)-PGJ2-S-glutathione conjugate 0
                                                        13,14-dihydro-Delta(12)-prostaglandin J2 4
                                                        15-deoxy-Delta(12,14)-prostaglandin J2 + 113
paths to the root