styrene - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	styrene	go back to main search page
Accession:	CHEBI:27452	browse the term
Definition:	A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.
Synonyms:	related_synonym:	Formula=C8H8; InChI=1S/C8H8/c1-2-8-6-4-3-5-7-8/h2-7H,1H2; InChIKey=PPBRXRYQALVLMV-UHFFFAOYSA-N; Phenylethylene; SMILES=C=Cc1ccccc1; Styren; Styrol; ethenylbenzene; phenylethene; vinylbenzene
	alt_id:	CHEBI:26796; CHEBI:9296
	xref:	Beilstein:1071236; CAS:100-42-5; Gmelin:2991; HMDB:HMDB0034240; KEGG:C07083
	xref_mesh:	MESH:D020058
	xref:	MetaCyc:CPD-1092; PMID:11934013; PMID:24320693; Reaxys:1071236; UM-BBD_compID:c0115; Wikipedia:Styrene

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Rat (119) Mouse (119) Human (118) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (119)

styrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminolevulinate dehydratase

decreases activity

Styrene results in decreased activity of ALAD protein

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

albumin

increases secretion
multiple interactions

Styrene results in increased secretion of ALB protein
Styrene promotes the reaction [styrene oxide binds to ALB protein]

PMID:10511253 PMID:15895243

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

alkaline phosphatase, biomineralization associated

multiple interactions

[[Volatile Organic Compounds results in increased abundance of Styrene] which results in increased abundance of mandelic acid] which results in increased expression of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

aquaporin 9

increases expression

Styrene results in increased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

activating transcription factor 3

affects expression

Styrene affects the expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase H+ transporting V0 subunit D2

increases expression

Styrene results in increased expression of ATP6V0D2 mRNA

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

BCL2 associated X, apoptosis regulator

decreases expression

Styrene results in decreased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression

Styrene results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

Styrene results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCL6, transcription repressor

decreases expression

Styrene results in decreased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

basic helix-loop-helix family, member e40

increases expression

Styrene results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

basic helix-loop-helix ARNT like 1

decreases expression

Styrene results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

bromodomain PHD finger transcription factor

decreases expression

Styrene results in decreased expression of BPTF mRNA

NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769

G

caspase 8

increases activity

Styrene results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Styrene results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity

Styrene results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression
affects expression

Styrene results in increased expression of CCL2 mRNA; Styrene results in increased expression of CCL2 protein
Styrene affects the expression of CCL2 mRNA

PMID:15212811 PMID:17993253 PMID:36912746

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

Styrene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine receptor 1

decreases expression

Styrene results in decreased expression of CCR1 mRNA; Styrene results in decreased expression of CCR1 protein

NCBI chr 8:123,556,286...123,561,841

G

clock circadian regulator

decreases expression

Styrene results in decreased expression of CLOCK mRNA

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

clusterin

decreases expression

Styrene results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

C-X-C motif chemokine ligand 2

affects expression

Styrene affects the expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

affects expression

Styrene affects the expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects response to substance

CYP1A1 gene polymorphism affects the susceptibility to Styrene

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]
Styrene results in increased expression of CYP1A2 mRNA; Styrene results in increased expression of CYP1A2 protein

PMID:16418063 PMID:18202523

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases expression

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]
Styrene results in increased expression of CYP2B1 mRNA; Styrene results in increased expression of CYP2B1 protein

PMID:16418063 PMID:18202523

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions
increases expression

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]
Styrene results in increased expression of CYP2B2 mRNA; Styrene results in increased expression of CYP2B2 protein

PMID:16418063 PMID:18202523

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

Styrene results in decreased expression of CYP2C11 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases metabolic processing
increases oxidation
increases metabolic processing
increases expression
affects response to substance
multiple interactions
increases response to substance
affects metabolic processing
affects oxidation

CYP2E1 gene polymorphism results in decreased metabolism of Styrene
CYP2E1 protein results in increased oxidation of Styrene
CYP2E1 protein results in increased metabolism of Styrene
Styrene results in increased expression of CYP2E1 mRNA
CYP2E1 gene polymorphism affects the susceptibility to Styrene
Styrene results in increased expression of CYP2E1 mRNA; Styrene results in increased expression of CYP2E1 protein
gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; [Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene
CYP2E1 protein results in increased susceptibility to Styrene
CYP2E1 protein affects the metabolism of Styrene
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene analog; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]; S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; Smoke inhibits the reaction [CYP2E1 protein affects the metabolism of Styrene]
CYP2E1 protein affects the oxidation of Styrene
CYP2E1 gene polymorphism results in increased susceptibility to Styrene; CYP2E1 protein results in increased susceptibility to Styrene
CYP2E1 gene polymorphism affects the metabolism of Styrene; CYP2E1 protein affects the metabolism of Styrene

PMID:1664256 PMID:11535253 PMID:12464798 PMID:12604177 PMID:12746132 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily f, polypeptide 4

increases response to substance
decreases response to substance
increases metabolic processing
multiple interactions

CYP2F2 protein results in increased susceptibility to Styrene
CYP2F2 gene mutant form results in decreased susceptibility to Styrene
CYP2F2 protein results in increased metabolism of Styrene
[CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of 4-vinylphenol; [CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of styrene glycol

PMID:22386858 PMID:24320693 PMID:28962520

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

D-box binding PAR bZIP transcription factor

increases expression

Styrene results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

E2F transcription factor 8

increases expression

Styrene results in increased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

early growth response 1

increases expression
affects expression

Styrene results in increased expression of EGR1 mRNA
Styrene affects the expression of EGR1 mRNA

PMID:24086524 PMID:28951217

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

epoxide hydrolase 1

increases expression
decreases response to substance
affects response to substance

Styrene results in increased expression of EPHX1 mRNA
EPHX1 protein results in decreased susceptibility to Styrene
EPHX1 gene polymorphism affects the susceptibility to Styrene

PMID:14751678 PMID:16418063 PMID:22386858

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

ETS transcription factor ERG

decreases expression

Styrene results in decreased expression of ERG mRNA

NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871

G

fibronectin 1

decreases expression

Styrene results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
affects expression

Styrene results in increased expression of FOS protein
Styrene affects the expression of FOS mRNA

PMID:15212811 PMID:28951217

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glucokinase

increases expression

Styrene results in increased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

increases activity

Styrene results in increased activity of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate dehydrogenase 1

affects expression

Styrene affects the expression of GLUD1 mRNA

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

glutathione S-transferase mu 1

increases response to substance
multiple interactions
affects response to substance

GSTM1 gene polymorphism results in increased susceptibility to Styrene
GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]
GSTM1 gene polymorphism affects the susceptibility to Styrene

PMID:12016165 PMID:12464798 PMID:12717779 PMID:14751678 PMID:14979085

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

affects response to substance
increases response to substance
multiple interactions

GSTP1 exon polymorphism affects the susceptibility to Styrene; GSTP1 gene polymorphism affects the susceptibility to Styrene
GSTP1 gene polymorphism results in increased susceptibility to Styrene
GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene]

PMID:11535253 PMID:12397415 PMID:12604177 PMID:12893075

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

multiple interactions
increases response to substance
affects response to substance

GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]
GSTT1 gene polymorphism affects the susceptibility to Styrene

PMID:12016165 PMID:12717779 PMID:14751678 PMID:16424821

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hes family bHLH transcription factor 6

increases expression

Styrene results in increased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

HLF transcription factor, PAR bZIP family member

increases expression

Styrene results in increased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

heme oxygenase 1

affects expression

Styrene affects the expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions
increases mutagenesis

GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene]

PMID:11535253 PMID:12893075

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

heat shock protein family A (Hsp70) member 1A

increases expression

Styrene results in increased expression of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1 like

increases expression

Styrene results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

interleukin 1 beta

increases expression
multiple interactions

Styrene results in increased expression of IL1B mRNA
Styrene results in increased expression of and results in increased secretion of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

decreases expression

Styrene results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
affects expression
multiple interactions

Styrene results in increased expression of IL6 mRNA
Styrene affects the expression of IL6 mRNA
Styrene results in increased expression of and results in increased secretion of IL6 protein

PMID:24086524 PMID:36912746

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

Styrene affects the expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KLF transcription factor 7

decreases expression

Styrene results in decreased expression of KLF7 mRNA

NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261

G

KRAS proto-oncogene, GTPase

increases response to substance

KRAS gene polymorphism results in increased susceptibility to Styrene

NCBI chr 4:178,185,418...178,218,484

G

lymphocyte cytosolic protein 2

decreases expression

Styrene results in decreased expression of LCP2 mRNA; Styrene results in decreased expression of LCP2 protein

NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559

G

Max dimerization protein 3

increases expression

Styrene results in increased expression of MXD3 mRNA

NCBI chr17:9,301,430...9,305,156
Ensembl chr17:9,301,399...9,305,157

G

MYB proto-oncogene, transcription factor

affects expression

Styrene affects the expression of MYB mRNA

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

nuclear factor, interleukin 3 regulated

affects expression
decreases expression

Styrene affects the expression of NFIL3 mRNA
Styrene results in decreased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

neuronal PAS domain protein 2

decreases expression

Styrene results in decreased expression of NPAS2 mRNA

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

NAD(P)H quinone dehydrogenase 1

affects response to substance

NQO1 gene polymorphism affects the susceptibility to Styrene

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Styrene results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group D, member 2

increases expression

Styrene results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 4, group A, member 1

affects expression

Styrene affects the expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

Styrene results in decreased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Styrene results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

8-oxoguanine DNA glycosylase

affects response to substance
increases expression

OGG1 protein polymorphism affects the susceptibility to Styrene
Styrene results in increased expression of OGG1 mRNA

PMID:19563869 PMID:21030303

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

protein kinase C and casein kinase substrate in neurons 3

increases expression

Styrene results in increased expression of PACSIN3 mRNA

NCBI chr 3:77,227,187...77,235,820
Ensembl chr 3:77,222,710...77,235,811

G

period circadian regulator 2

increases expression

Styrene results in increased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

period circadian regulator 3

increases expression

Styrene results in increased expression of PER3 mRNA

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

cytochrome p450 oxidoreductase

increases metabolic processing
increases response to substance

POR protein results in increased metabolism of Styrene
POR protein results in increased susceptibility to Styrene

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxiredoxin 1

increases expression

Styrene results in increased expression of PRDX1 mRNA

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Styrene results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Styrene results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

increases response to substance

PTHLH gene polymorphism results in increased susceptibility to Styrene

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression

Styrene results in increased expression of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAR-related orphan receptor A

decreases expression

Styrene results in decreased expression of RORA mRNA

NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931

G

secretoglobin family 1A member 1

decreases expression

Styrene results in decreased expression of SCGB1A1 mRNA

NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610

G

solute carrier family 2 member 2

decreases expression

Styrene results in decreased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

Sp5 transcription factor

increases expression

Styrene results in increased expression of SP5 mRNA

NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733

G

TEF transcription factor, PAR bZIP family member

increases expression

Styrene results in increased expression of TEF mRNA

NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783

G

testis expressed 101

increases expression

Styrene results in increased expression of TEX101 mRNA

NCBI chr 1:80,255,076...80,259,442
Ensembl chr 1:80,255,076...80,259,442

G

transcription factor EC

affects expression

Styrene affects the expression of TFEC mRNA

NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236

G

transforming growth factor, beta 1

affects expression

Styrene affects the expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

affects expression

Styrene affects the expression of TGFB2 mRNA; Styrene affects the expression of TGFB2 protein

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor beta receptor 3

affects expression

Styrene affects the expression of TGFBR3 mRNA; Styrene affects the expression of TGFBR3 protein

NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341

G

transglutaminase 2

affects expression

Styrene affects the expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

tumor necrosis factor

multiple interactions
affects expression
increases expression

Styrene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Styrene results in increased expression of and results in increased secretion of TNF protein
Styrene affects the expression of TNF mRNA
Styrene results in increased expression of TNF mRNA

PMID:24086524 PMID:36416909 PMID:36912746

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

increases expression
multiple interactions

Styrene results in increased expression of TNFSF10 mRNA
Styrene results in increased expression of and results in increased secretion of TNFSF10 protein

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

transient receptor potential cation channel, subfamily A, member 1

increases response to substance

TRPA1 results in increased susceptibility to Styrene

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

vascular cell adhesion molecule 1

affects expression

Styrene affects the expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

X-ray repair cross complementing 1

increases response to substance
increases expression
affects response to substance

XRCC1 gene polymorphism results in increased susceptibility to Styrene
Styrene results in increased expression of XRCC1 mRNA
XRCC1 protein polymorphism affects the susceptibility to Styrene

PMID:15468052 PMID:15992842 PMID:21030303

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 3

affects response to substance

XRCC3 protein polymorphism affects the susceptibility to Styrene

NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444

G

zinc finger and BTB domain containing 20

decreases expression

Styrene results in decreased expression of ZBTB20 mRNA

NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210

G

zinc finger with KRAB and SCAN domains 3

decreases expression

Styrene results in decreased expression of ZKSCAN3 mRNA

NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827

4-hydroxystyrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions
increases abundance

[CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of 4-vinylphenol
CYP2F2 protein results in increased abundance of 4-vinylphenol

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

styrene oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions
affects binding

styrene oxide promotes the reaction [styrene oxide binds to ALB protein]; Styrene promotes the reaction [styrene oxide binds to ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

BCL2 associated X, apoptosis regulator

affects expression
increases expression

styrene oxide affects the expression of BAX mRNA
styrene oxide results in increased expression of BAX protein

PMID:11230554 PMID:12663515

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

affects expression
decreases expression

styrene oxide affects the expression of BCL2 mRNA
styrene oxide results in decreased expression of BCL2 protein

PMID:11230554 PMID:12663515

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

styrene oxide results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 3

increases activity

styrene oxide results in increased activity of CASP3 protein

PMID:11929631 PMID:12663515 PMID:17662326 PMID:19666080

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin-dependent kinase inhibitor 1A

affects expression

styrene oxide affects the expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

checkpoint kinase 1

increases expression

styrene oxide results in increased expression of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases chemical synthesis

CYP2E1 results in increased chemical synthesis of styrene oxide; CYP2E1 results in increased chemical synthesis of styrene oxide analog

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily f, polypeptide 4

increases chemical synthesis

CYP2F2 protein results in increased chemical synthesis of styrene oxide

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

epoxide hydrolase 1

multiple interactions
affects hydrolysis

CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]
EPHX1 protein affects the metabolism of and results in decreased activity of styrene oxide

PMID:11076696 PMID:12051674 PMID:12694745

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

FOS like 1, AP-1 transcription factor subunit

increases expression

styrene oxide results in increased expression of FOSL1 protein

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

glutathione S-transferase mu 1

decreases response to substance
multiple interactions
affects metabolic processing

GSTM1 protein results in decreased susceptibility to styrene oxide
GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
GSTM1 protein affects the metabolism of styrene oxide

PMID:1638515 PMID:2604743 PMID:11424177 PMID:11599931 PMID:14698568 More...

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

affects metabolic processing
multiple interactions

GSTM2 protein affects the metabolism of styrene oxide
GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]

PMID:1638515 PMID:2604743

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

affects response to substance

GSTP1 exon polymorphism affects the susceptibility to styrene oxide

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

increases response to substance
affects response to substance

GSTT1 gene polymorphism results in increased susceptibility to styrene oxide
GSTT1 protein affects the susceptibility to styrene oxide

PMID:12016165 PMID:15468052

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hemoglobin subunit beta

affects binding

styrene oxide binds to HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

helicase, lymphoid specific

increases expression

styrene oxide results in increased expression of HELLS protein

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

heme oxygenase 1

increases expression
increases activity

styrene oxide results in increased expression of HMOX1 protein
styrene oxide results in increased activity of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 receptor-like 1

increases expression

styrene oxide results in increased expression of IL1RL1 protein

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

minichromosome maintenance complex component 3

increases expression

styrene oxide results in increased expression of MCM3 protein

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

MYC proto-oncogene, bHLH transcription factor

increases expression

styrene oxide results in increased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

orosomucoid 1

increases expression

styrene oxide results in increased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

poly (ADP-ribose) polymerase 1

increases cleavage

styrene oxide results in increased cleavage of PARP1 protein

PMID:11929631 PMID:17662326

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphate regulating endopeptidase X-linked

increases expression

styrene oxide results in increased expression of PHEX protein

NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469

G

cytochrome p450 oxidoreductase

increases chemical synthesis

POR protein results in increased chemical synthesis of styrene oxide

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

Rac family small GTPase 1

decreases expression

styrene oxide results in decreased expression of RAC1 protein

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

secretoglobin family 1A member 1

decreases expression

styrene oxide results in decreased expression of SCGB1A1 mRNA; styrene oxide results in decreased expression of SCGB1A1 protein

NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610

G

spectrin, alpha, non-erythrocytic 1

increases cleavage

styrene oxide results in increased cleavage of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

synaptophysin

decreases expression

styrene oxide results in decreased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

transforming growth factor, beta 2

affects expression

styrene oxide affects the expression of TGFB2 mRNA; styrene oxide affects the expression of TGFB2 protein

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor beta receptor 3

affects expression

styrene oxide affects the expression of TGFBR3 mRNA; styrene oxide affects the expression of TGFBR3 protein

NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341

G

TNF receptor superfamily member 9

increases expression

styrene oxide results in increased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

tumor protein p53

affects expression

styrene oxide affects the expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

X-ray repair cross complementing 1

affects response to substance

XRCC1 protein polymorphism affects the susceptibility to styrene oxide

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

tetrachlorvinphos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Tetrachlorvinphos metabolite results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

androgen receptor

multiple interactions

Tetrachlorvinphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

estrogen receptor 1

multiple interactions

Tetrachlorvinphos binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Tetrachlorvinphos binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Tetrachlorvinphos binds to and results in increased activity of NR1I2 protein

PMID:21115097 PMID:33049310

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Tetrachlorvinphos binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

tumor protein p53

affects activity

Tetrachlorvinphos metabolite affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19922
role	19894
biological role	19864
aetiopathogenetic role	19237
genotoxin	17689
mutagen	17602
styrene	119
1-phenylethenol +	7
4-hydroxystyrene +	1
styrene oxide +	37
Path 2
Term	Annotations
CHEBI ontology	19922
subatomic particle	19892
composite particle	19892
hadron	19920
baryon	19892
nucleon	19920
atomic nucleus	19892
atom	19892
main group element atom	19866
p-block element atom	19866
carbon group element atom	19805
carbon atom	19802
organic molecular entity	19775
organic molecule	19755
organic cyclic compound	19545
carbocyclic compound	18619
benzenoid aromatic compound	18046
benzenes	17911
styrenes	248
styrene	119
1-phenylethenol +	7
4-hydroxystyrene +	1
styrene oxide +	37

paths to the root