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G |
Cat |
catalase |
multiple interactions |
EXP |
4-methoxycinnamic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CAT] |
CTD |
PMID:22326950 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
4-methoxycinnamic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of GSR] |
CTD |
PMID:22326950 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
ethyl cinnamate binds to and results in increased activity of ESR1 protein |
CTD |
PMID:16079615 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
ethyl cinnamate binds to and results in increased activity of ESR2 protein |
CTD |
PMID:16079615 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
lucidone results in increased expression of HMOX1 protein [lucidone co-treated with 2,2'-azobis(2-amidinopropane)] results in increased expression of HMOX1 protein; lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein] |
CTD |
PMID:22484158 PMID:23712098 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects response to substance |
ISO |
[lucidone co-treated with 2,2'-azobis(2-amidinopropane)] affects the localization of and results in increased activity of NFE2L2 protein; [lucidone co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; lucidone affects the localization of and results in increased activity of NFE2L2 protein; lucidone promotes the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of NFE2L2 protein] NFE2L2 protein affects the susceptibility to lucidone |
CTD |
PMID:22484158 PMID:23712098 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of NFKBIA protein] |
CTD |
PMID:23712098 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of PTGS2 protein] |
CTD |
PMID:23712098 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) affects the localization of RELA protein] |
CTD |
PMID:23712098 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
lucidone inhibits the reaction [Ethanol results in increased expression of TNF] |
CTD |
PMID:22484158 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in increased expression of BAX protein] |
CTD |
PMID:30144576 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in decreased expression of BCL2 protein] |
CTD |
PMID:30144576 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein] |
CTD |
PMID:30144576 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
cinnamic acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein] cinnamic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein] |
CTD |
PMID:22285266 PMID:23959918 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of CYP17A1 protein |
CTD |
PMID:15072549 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of CYP2C19 protein |
CTD |
PMID:15072549 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of CYP2C8 protein |
CTD |
PMID:15072549 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of CYP2D6 protein |
CTD |
PMID:15072549 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of CYP2E1 protein |
CTD |
PMID:15072549 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of CYP3A4 protein |
CTD |
PMID:15072549 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in increased expression of DNM1L protein] |
CTD |
PMID:30144576 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in increased expression of FIS1 protein] |
CTD |
PMID:30144576 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Hcar2 |
hydroxycarboxylic acid receptor 2 |
affects binding |
ISO |
cinnamic acid binds to HCAR2 protein |
CTD |
PMID:21167710 |
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NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases expression |
ISO |
cinnamic acid results in decreased expression of HMGCR mRNA |
CTD |
PMID:21870829 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
decreases activity |
ISO |
cinnamic acid analog results in decreased activity of HSD3B2 protein |
CTD |
PMID:15072549 |
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NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
cinnamic acid results in increased expression of IL6 mRNA |
CTD |
PMID:21870829 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mfn2 |
mitofusin 2 |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in decreased expression of MFN2 protein] |
CTD |
PMID:30144576 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
cinnamic acid analog binds to and results in decreased activity of MMP2 protein |
CTD |
PMID:30048736 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
cinnamic acid analog binds to and results in decreased activity of MMP9 protein |
CTD |
PMID:30048736 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression |
ISO |
cinnamic acid results in increased expression of NOS3 mRNA |
CTD |
PMID:15740983 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in increased expression of NPPA protein] |
CTD |
PMID:30144576 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
cinnamic acid binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
multiple interactions |
EXP |
cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein] |
CTD |
PMID:30144576 |
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NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases expression |
ISO |
cinnamic acid results in increased expression of PIK3R1 mRNA |
CTD |
PMID:21870829 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
ISO |
cinnamic acid results in increased expression of PPARG mRNA |
CTD |
PMID:21870829 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Slc22a7 |
solute carrier family 22 member 7 |
multiple interactions |
ISO EXP |
cinnamic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] |
CTD |
PMID:22981274 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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G |
Slc2a4 |
solute carrier family 2 member 4 |
increases expression |
ISO |
cinnamic acid results in increased expression of SLC2A4 mRNA |
CTD |
PMID:21870829 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
cinnamic acid results in increased expression of TNF mRNA |
CTD |
PMID:21870829 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tyr |
tyrosinase |
increases oxidation multiple interactions |
ISO |
TYR protein results in increased oxidation of cinnamic acid [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione |
CTD |
PMID:20685355 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of cinnamic acid |
CTD |
PMID:15117964 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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