zinc atom - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	zinc atom	go back to main search page
Accession:	CHEBI:27363	browse the term
Definition:	A zinc group element atom that has formula Zn.
Synonyms:	related_synonym:	30Zn; Zink; Zn; Zn(II); Zn2+; cinc; zinc; zincum
	xref:	CAS:7440-66-6; Gmelin:16321
	xref_mesh:	MESH:D015032
	xref:	WebElements:Zn; kegg.compound:C00038; pdb-ccd:ZN
	chemrof_inchikey:	HCHKCACWOHOZIP-UHFFFAOYSA-N
	chemrof_inchi:	InChI=1S/Zn
	chemrof_formula:	Zn
	chemrof_smiles:	[Zn]

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Genes (2866)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

affects binding

ISO

A1BG protein binds to Zinc

NCBI chr 7:94,383,333...94,387,922
Ensembl chr 7:94,383,333...94,387,496

G

alpha-2-macroglobulin

affects binding

ISO

A2M protein binds to Zinc

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

alanyl-tRNA synthetase 1

increases expression

ISO

Zinc deficiency results in increased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

decreases expression

ISO

Zinc deficiency results in decreased expression of AASDHPPT mRNA

NCBI chr 8:9,731,592...9,748,934
Ensembl chr 8:9,738,172...9,748,953

G

aminoadipate-semialdehyde synthase

decreases expression

ISO

Zinc deficiency results in decreased expression of AASS mRNA

NCBI chr 4:52,572,146...52,628,811
Ensembl chr 4:52,572,147...52,657,600

G

ATP binding cassette subfamily A member 1

increases expression

ISO

Zinc deficiency results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily A member 9

decreases expression

ISO

Zinc deficiency results in decreased expression of ABCA9 mRNA

NCBI chr10:95,577,079...95,638,706
Ensembl chr10:95,578,350...95,636,405

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

Zinc inhibits the reaction [Magnesium results in increased activity of ABCB1 protein]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 9

increases expression

ISO

Zinc deficiency results in increased expression of ABCB9 mRNA

NCBI chr12:38,146,659...38,192,862
Ensembl chr12:38,159,904...38,192,860

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily F member 2

increases expression

ISO

Zinc deficiency results in increased expression of ABCF2 mRNA

NCBI chr 4:11,485,865...11,500,067
Ensembl chr 4:11,487,395...11,500,053

G

ATP binding cassette subfamily G member 1

increases expression

EXP
ISO

Zinc results in increased expression of ABCG1 mRNA
Zinc deficiency results in increased expression of ABCG1 mRNA

PMID:17074742 PMID:22171008

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ATP binding cassette subfamily G member 5

decreases expression

ISO

Zinc deficiency results in decreased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

abhydrolase domain containing 2, acylglycerol lipase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

affects expression

ISO

Zinc affects the expression of ABL1 protein

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

ankyrin repeat and BTB domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ABTB2 mRNA

NCBI chr 3:110,409,672...110,563,488
Ensembl chr 3:110,409,627...110,563,487

G

acetyl-CoA acyltransferase 1A

affects expression
decreases expression

EXP

Zinc affects the expression of ACAA1A mRNA
Zinc deficiency results in decreased expression of ACAA1A mRNA

PMID:12672911 PMID:15671213 PMID:16413754

NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241

G

acetyl-CoA acyltransferase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of ACAA2 mRNA; Zinc deficiency results in decreased expression of ACAA2 protein

PMID:12672911 PMID:15671213

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

acetyl-CoA carboxylase alpha

affects expression
decreases expression
multiple interactions

EXP
ISO

Zinc affects the expression of ACACA mRNA
Zinc deficiency results in decreased expression of ACACA mRNA
[Zinc deficiency co-treated with Ethanol] results in decreased expression of ACACA mRNA

PMID:17181878 PMID:24155903

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acetyl-CoA carboxylase beta

increases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of ACACB mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ACACB mRNA

PMID:17074742 PMID:33549593

NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214

G

acyl-CoA dehydrogenase, long chain

multiple interactions

ISO

Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ACADL protein]
[Ethanol co-treated with Zinc] results in increased expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164

G

acyl-CoA dehydrogenase short chain

increases expression

ISO

Zinc results in increased expression of ACADS mRNA

NCBI chr12:47,154,259...47,163,580
Ensembl chr12:47,154,276...47,164,103

G

acyl-CoA dehydrogenase, short/branched chain

increases expression

EXP
ISO

Zinc results in increased expression of ACADSB mRNA
Zinc deficiency results in increased expression of ACADSB mRNA

PMID:17074742 PMID:18356318

NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561

G

acyl-CoA dehydrogenase, very long chain

increases expression

EXP

Zinc results in increased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750

G

angiotensin I converting enzyme

decreases activity

ISO

Zinc results in decreased activity of ACE protein

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

acetylcholinesterase

multiple interactions

EXP

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [zinc chloride results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of ACHE protein]; [Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in decreased activity of ACHE protein]; [Zinc co-treated with Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [sodium arsenite results in increased activity of ACHE protein]

PMID:20688495 PMID:23619517 PMID:29233033 PMID:37415728

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

atypical chemokine receptor 3

decreases expression

ISO

Zinc deficiency results in decreased expression of ACKR3 mRNA

NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214

G

ATP citrate lyase

increases expression

EXP

Zinc deficiency results in increased expression of ACLY mRNA

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

aconitase 1

decreases activity

ISO

Zinc deficiency results in decreased activity of ACO1 protein

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

affects binding

ISO

Zinc binds to ACO2 protein

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 7

decreases expression

EXP

Zinc deficiency results in decreased expression of ACOT7 mRNA

NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:167,968,895...168,062,033

G

acyl-CoA oxidase 1

decreases expression
multiple interactions
affects expression

EXP
ISO

Zinc deficiency results in decreased expression of ACOX1 mRNA
[Zinc deficiency co-treated with Ethanol] affects the expression of ACOX1 mRNA
Zinc deficiency affects the expression of ACOX1 mRNA

PMID:15671213 PMID:24155903

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acyl-CoA oxidase 2

increases expression

EXP

Zinc deficiency results in increased expression of ACOX2 mRNA

NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392

G

acid phosphatase 5, tartrate resistant

decreases activity
decreases expression

EXP

Zinc deficiency results in decreased activity of ACP5 protein
Zinc deficiency results in decreased expression of ACP5 mRNA

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

acyl-CoA synthetase long-chain family member 1

increases expression
decreases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of ACSL1 mRNA
Zinc deficiency results in decreased expression of ACSL1 mRNA
[Zinc deficiency co-treated with Ethanol] results in increased expression of ACSL1 mRNA

PMID:12672911 PMID:15671213 PMID:24155903

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

acyl-CoA synthetase long-chain family member 5

increases expression

EXP

Zinc deficiency results in increased expression of ACSL5 mRNA

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943

G

actin alpha 2, smooth muscle

decreases expression

ISO

Zinc deficiency results in decreased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

actin, beta

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of ACTB mRNA

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

actin, alpha, cardiac muscle 1

decreases expression

EXP

Zinc results in decreased expression of ACTC1 mRNA

NCBI chr 3:121,266,291...121,271,827
Ensembl chr 3:121,266,291...121,271,827

G

actinin alpha 3

decreases expression

EXP

Zinc deficiency results in decreased expression of ACTN3 mRNA

NCBI chr 1:211,588,473...211,604,401
Ensembl chr 1:211,588,474...211,604,401

G

actin related protein 3

increases expression

EXP

Zinc deficiency results in increased expression of ACTR3 mRNA

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

activin A receptor type 2A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ACVR2A mRNA

NCBI chr 3:53,614,143...53,701,933
Ensembl chr 3:53,614,171...53,701,941

G

adenosine deaminase

multiple interactions

EXP

[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Streptozocin results in increased activity of ADA protein]

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293

G

ADAM metallopeptidase domain 12

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM12 mRNA

NCBI chr 1:198,116,968...198,443,680
Ensembl chr 1:198,116,975...198,447,552

G

ADAM metallopeptidase domain 19

increases expression

ISO

Zinc deficiency results in increased expression of ADAM19 mRNA

NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,992,754...31,084,455

G

ADAM metallopeptidase domain 2

decreases expression

ISO

Zinc results in decreased expression of ADAM2 mRNA

NCBI chr15:44,418,191...44,459,570
Ensembl chr15:44,418,199...44,459,516

G

ADAM metallopeptidase domain 3A

decreases expression

ISO

Zinc deficiency results in decreased expression of ADAM3A mRNA

NCBI chr16:74,002,566...74,052,579
Ensembl chr16:74,002,410...74,052,578

G

ADAM metallopeptidase domain 8

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM8 mRNA

NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:204,206,199...204,218,485

G

adhesion G protein-coupled receptor E1

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of ADGRE1 mRNA]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

adhesion G protein-coupled receptor G2

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ADGRG2 mRNA

NCBI chr X:38,106,067...38,231,286
Ensembl chr X:38,106,067...38,231,331

G

adhesion G protein-coupled receptor L4

decreases expression

ISO

Zinc deficiency results in decreased expression of ADGRL4 mRNA

NCBI chr 2:243,014,927...243,117,226
Ensembl chr 2:243,014,796...243,117,222

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of ADH1C mRNA
[Zinc co-treated with Ethanol] results in increased expression of ADH1 mRNA

PMID:12672911 PMID:19637192

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

alcohol dehydrogenase 4 (class II), pi polypeptide

multiple interactions

ISO

Zinc inhibits the reaction [Ethanol results in decreased expression of ADH4 mRNA]

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

ISO

[Zinc co-treated with Ethanol] results in increased expression of ADH5 mRNA

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232

G

alcohol dehydrogenase 6 (class V)

increases expression

ISO

Zinc deficiency results in increased expression of ADH6 mRNA

NCBI chr 2:229,576,612...229,608,359
Ensembl chr 2:229,576,636...229,607,914

G

adiponectin receptor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ADIPOR2 mRNA

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666

G

adrenomedullin

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

ADNP homeobox 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ADNP2 mRNA

NCBI chr18:75,846,860...75,871,638
Ensembl chr18:75,847,165...75,903,317

G

adrenoceptor alpha 1A

increases expression

ISO

Zinc deficiency results in increased expression of ADRA1A mRNA

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor beta 2

multiple interactions

ISO

Zinc binds to and results in increased activity of ADRB2 protein; Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]

PMID:11752207 PMID:16567806

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

apoptosis enhancing nuclease

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AEN mRNA

NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:142,224,493...142,233,898

G

ALF transcription elongation factor 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AFF4 mRNA

NCBI chr10:37,998,319...38,080,580
Ensembl chr10:37,999,579...38,080,580

G

advanced glycosylation end product-specific receptor

multiple interactions
increases expression

ISO
EXP

PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of AGER protein]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of AGER protein]]
Zinc inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of AGER protein]

PMID:19111725 PMID:20857495 PMID:31009641

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

argonaute RISC catalytic component 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AGO2 mRNA

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

anterior gradient 2, protein disulphide isomerase family member

increases expression

ISO

Zinc deficiency results in increased expression of AGR2 mRNA

NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:58,435,908...58,456,677

G

angiotensinogen

increases localization
affects binding
multiple interactions

EXP
ISO

AGT protein results in increased localization of Zinc
AGT protein binds to Zinc
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in increased localization of Zinc]; Zinc inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Zinc promotes the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Zinc promotes the reaction [AGT protein results in increased phosphorylation of AKT1 protein]

PMID:22427991 PMID:23896426

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

alanine--glyoxylate aminotransferase

decreases expression

ISO

Zinc deficiency results in decreased expression of AGXT mRNA

NCBI chr 9:101,122,793...101,132,746
Ensembl chr 9:101,122,793...101,132,745

G

aryl hydrocarbon receptor

multiple interactions

EXP

Zinc inhibits the reaction [1,10-phenanthroline results in decreased activity of AHR protein]; Zinc inhibits the reaction [Oxalic Acid results in decreased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

activator of Hsp90 ATPase activity 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AHSA1 mRNA

NCBI chr 6:112,644,287...112,652,290
Ensembl chr 6:112,644,479...112,655,595

G

activator of HSP90 ATPase homolog 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AHSA2P mRNA

NCBI chr14:101,677,447...101,688,706
Ensembl chr14:101,677,447...101,686,923

G

alpha-2-HS-glycoprotein

affects binding

ISO

AHSG protein binds to Zinc

NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039

G

allograft inflammatory factor 1

multiple interactions
increases expression

EXP

Paraquat promotes the reaction [Zinc results in increased expression of AIF1 protein]; Zinc promotes the reaction [Paraquat results in increased expression of AIF1 protein]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

adenylate kinase 3

decreases expression

ISO

Zinc results in decreased expression of AK3 protein

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

A-kinase anchoring protein 17A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AKAP17A mRNA

NCBI chr12:21,424,202...21,428,308
Ensembl chr12:21,424,202...21,428,247

G

akirin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AKIRIN1 mRNA

NCBI chr 5:141,274,174...141,289,617
Ensembl chr 5:141,274,175...141,289,575

G

aldo-keto reductase family 1 member A1

decreases expression

EXP

Zinc deficiency results in decreased expression of AKR1A1 mRNA

NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035

G

aldo-keto reductase family 1 member B15

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of AKR1B8 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of AKR1B8 mRNA]

NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349

G

aldo-keto reductase family 1, member B7

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA

NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909

G

aldo-keto reductase family 1, member C1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C14

decreases expression

EXP

Zinc deficiency results in decreased expression of AKR1C14 mRNA

NCBI chr17:71,066,197...71,083,184
Ensembl chr17:71,066,200...71,083,157

G

aldo-keto reductase family 1, member C3

decreases expression

ISO

Zinc deficiency results in decreased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; AG 1879 inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; AKT1 protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; PTEN protein inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; SB 203580 inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; SLC39A7 mutant form inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of AKT1 protein
Zinc deficiency results in decreased phosphorylation of AKT1 protein
Zinc results in increased expression of AKT1 mRNA
Zinc results in decreased phosphorylation of AKT1 protein
[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of AKT1 protein; Acetylcysteine inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]; Zinc promotes the reaction [AGT protein results in increased phosphorylation of AKT1 protein]

PMID:15980035 PMID:16973122 PMID:17098228 PMID:17513037 PMID:19071009 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

increases expression

EXP

Zinc deficiency results in increased expression of AKT2 mRNA

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

AKT serine/threonine kinase 3

decreases expression

ISO

Zinc deficiency results in decreased expression of AKT3 mRNA

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020

G

aminolevulinate dehydratase

affects activity
multiple interactions

EXP
ISO

Zinc affects the activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]

PMID:2033469 PMID:21910133

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

5'-aminolevulinate synthase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

albumin

affects binding
multiple interactions

ISO
EXP

ALB protein binds to Zinc; Zinc binds to ALB protein
[Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; [Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of ALB protein; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; Zinc inhibits the reaction [Glyphosate results in increased expression of ALB protein]

PMID:17034863 PMID:23896426 PMID:25067936 PMID:30090589 PMID:37676925

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 1 family, member A2

decreases expression

ISO

Zinc deficiency results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883

G

aldehyde dehydrogenase 2 family member

multiple interactions

ISO

[Zinc co-treated with Ethanol] results in increased expression of ALDH2 mRNA

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 3 family, member B1

increases expression

ISO

Zinc deficiency results in increased expression of ALDH3B1 mRNA

NCBI chr 1:210,574,545...210,605,188
Ensembl chr 1:210,573,661...210,610,538

G

aldehyde dehydrogenase 6 family, member A1

increases expression
decreases expression

ISO
EXP

Zinc deficiency results in increased expression of ALDH6A1 mRNA
Zinc deficiency results in decreased expression of ALDH6A1 protein

PMID:15671213 PMID:22171008

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743

G

aldolase, fructose-bisphosphate A

affects binding

ISO

ALDOA protein binds to Zinc

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

ALG2, alpha-1,3/1,6-mannosyltransferase

affects binding

ISO

Zinc binds to ALG2 protein

NCBI chr 5:66,564,328...66,568,887
Ensembl chr 5:66,564,330...66,568,887

G

arachidonate 15-lipoxygenase

affects expression

EXP

Zinc affects the expression of ALOX15 mRNA

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

arachidonate 5-lipoxygenase

increases expression

ISO

Zinc deficiency results in increased expression of ALOX5 mRNA

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

alkaline phosphatase, biomineralization associated

increases expression
multiple interactions
decreases expression

EXP
ISO

Zinc results in increased expression of ALPL mRNA
[Zinc binds to calcium silicate] which results in increased expression of ALPL mRNA
Zinc deficiency results in decreased expression of ALPL mRNA

PMID:16413754 PMID:21893222 PMID:23483914

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

alpha-methylacyl-CoA racemase

decreases expression

EXP

Zinc deficiency results in decreased expression of AMACR mRNA

NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:61,670,475...61,685,379

G

ameloblastin

decreases expression

ISO

Zinc deficiency results in decreased expression of AMBN mRNA

NCBI chr14:19,885,802...19,898,422
Ensembl chr14:19,885,743...19,898,433

G

alpha-1-microglobulin/bikunin precursor

affects binding

ISO

AMBP protein binds to Zinc

NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850

G

AMMECR1 like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AMMECR1L mRNA

NCBI chr18:23,661,649...23,685,391
Ensembl chr18:23,661,341...23,685,649

G

angiopoietin 1

decreases expression

ISO

Zinc deficiency results in decreased expression of ANGPT1 mRNA

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

ankyrin repeat domain containing 11

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ANKRD11 mRNA

NCBI chr19:67,848,836...68,007,491
Ensembl chr19:67,848,844...68,007,491

G

ankyrin repeat domain 12

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ANKRD12 mRNA

NCBI chr 9:113,030,127...113,134,816
Ensembl chr 9:113,030,919...113,134,762

G

ankyrin repeat domain 37

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ANKRD37 mRNA

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545

G

ankyrin repeat domain 46

decreases expression

ISO

Zinc deficiency results in decreased expression of ANKRD46 mRNA

NCBI chr 7:69,532,303...69,553,311
Ensembl chr 7:69,532,304...69,545,421

G

alanyl aminopeptidase, membrane

decreases expression

EXP

Zinc deficiency results in decreased expression of ANPEP mRNA

NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101

G

annexin A1

affects expression

ISO

Zinc affects the expression of ANXA1 mRNA

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A10

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ANXA10 mRNA
Zinc deficiency results in increased expression of ANXA10 mRNA

PMID:16979875 PMID:18356318 PMID:20857495

NCBI chr16:32,505,025...32,571,961
Ensembl chr16:32,467,126...32,571,961

G

annexin A2

decreases expression

EXP

Zinc results in decreased expression of ANXA2 mRNA

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

annexin A3

affects expression
multiple interactions

ISO

Zinc affects the expression of ANXA3 mRNA
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ANXA3 mRNA

NCBI chr14:13,031,675...13,085,678
Ensembl chr14:13,023,762...13,085,849

G

amine oxidase, copper containing 2, pseudogene 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AOC2 mRNA

NCBI chr10:86,767,268...86,768,734

G

aldehyde oxidase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

adaptor related protein complex 1 subunit gamma 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AP1G1 mRNA

NCBI chr19:54,654,101...54,740,586
Ensembl chr19:54,620,807...54,740,586

G

adaptor related protein complex 4 subunit beta 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AP4B1 mRNA

NCBI chr 2:194,006,926...194,018,971
Ensembl chr 2:194,006,919...194,018,968

G

adaptor related protein complex 5 subunit zeta 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AP5Z1 mRNA

NCBI chr12:17,207,315...17,222,975
Ensembl chr12:17,207,315...17,222,467

G

APC regulator of WNT signaling pathway

decreases expression

ISO

Zinc deficiency results in decreased expression of APC mRNA

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022

G

amyloid P component, serum

affects binding

ISO

APCS protein binds to Zinc

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

acylaminoacyl-peptide hydrolase

decreases expression

EXP

Zinc deficiency results in decreased expression of APEH mRNA

NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:117,652,393...117,661,711

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

EXP

Zinc deficiency results in decreased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

amyloid beta precursor like protein 1

affects binding
affects localization
multiple interactions

ISO

APLP1 protein binds to Zinc
Zinc affects the localization of APLP1 protein
Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein]; Zinc promotes the reaction [APLP1 protein binds to APLP1 protein]; Zinc promotes the reaction [APLP1 protein binds to APLP2 protein]; Zinc promotes the reaction [APP protein binds to APLP1 protein]

NCBI chr 1:94,824,330...94,834,705
Ensembl chr 1:94,824,072...94,834,610

G

amyloid beta precursor like protein 2

affects binding
affects localization
multiple interactions

ISO

APLP2 protein binds to Zinc
Zinc affects the localization of APLP2 protein
Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein]; Zinc promotes the reaction [APLP1 protein binds to APLP2 protein]; Zinc promotes the reaction [APLP2 protein binds to APLP2 protein]; Zinc promotes the reaction [APP protein binds to APLP2 protein]

NCBI chr 8:37,857,407...37,920,487
Ensembl chr 8:37,857,407...37,920,031

G

apolipoprotein A1

decreases expression
affects binding
increases expression

ISO

Zinc deficiency results in decreased expression of APOA1 mRNA; Zinc results in decreased expression of APOA1 protein
APOA1 protein binds to Zinc
Zinc results in increased expression of APOA1 mRNA

PMID:12107072 PMID:12679171 PMID:23896426

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein A2

affects binding

ISO

APOA2 protein binds to Zinc

NCBI chr13:86,176,767...86,178,819
Ensembl chr13:86,174,741...86,179,410

G

apolipoprotein A4

affects binding

ISO

APOA4 protein binds to Zinc

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein B

multiple interactions
affects binding
affects expression
decreases expression

ISO
EXP

Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of APOB protein]
APOB protein binds to Zinc
Zinc deficiency affects the expression of APOB mRNA
[Ethanol co-treated with Zinc] results in increased expression of APOB mRNA; [Zinc deficiency co-treated with Ethanol] affects the expression of APOB mRNA
Zinc deficiency affects the expression of APOB mRNA modified form
Zinc deficiency results in decreased expression of APOB protein modified form

PMID:10498758 PMID:19637192 PMID:23896426 PMID:24155903

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

decreases expression

EXP

Zinc deficiency results in decreased expression of APOBEC1 mRNA

NCBI chr 4:157,472,879...157,500,496
Ensembl chr 4:157,472,868...157,498,909

G

apolipoprotein E

affects binding

ISO

APOE protein binds to Zinc

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amyloid beta precursor protein

multiple interactions
increases expression
increases degradation
increases secretion
affects binding

ISO
EXP

Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; Zinc binds to and affects the folding of APP protein; Zinc inhibits the reaction [APP protein modified form results in increased reduction of Copper]; Zinc inhibits the reaction [APP protein results in increased reduction of Copper]; Zinc promotes the reaction [APP protein binds to APLP1 protein]; Zinc promotes the reaction [APP protein binds to APLP2 protein]; Zinc promotes the reaction [APP protein binds to APP protein]; Zinc promotes the reaction [Heparin binds to APP protein]
Zinc deficiency results in increased expression of APP mRNA
[APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form
Zinc results in increased degradation of APP protein modified form
[Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of Potassium
APP protein binds to Zinc; APP protein modified form binds to Zinc; Zinc binds to APP protein; Zinc binds to APP protein alternative form

PMID:12572668 PMID:15677459 PMID:15699049 PMID:16266835 PMID:16325427 More...

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 1

increases expression

EXP

Zinc results in increased expression of AQP1 mRNA

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

aquaporin 4

decreases expression

EXP

Zinc deficiency results in decreased expression of AQP4 mRNA

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098

G

androgen receptor

decreases activity
multiple interactions

EXP

Zinc results in decreased activity of AR protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of AR mRNA]; Zinc inhibits the reaction [Androgens binds to AR protein]

PMID:6323860 PMID:39106537

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARAP2 mRNA

NCBI chr14:50,921,323...51,120,972
Ensembl chr14:50,921,713...51,120,962

G

activity-regulated cytoskeleton-associated protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARC mRNA

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

amphiregulin

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of AREG mRNA
Zinc deficiency results in increased expression of AREG mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of AREG mRNA]

PMID:11717422 PMID:18593933 PMID:19111725

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

ARF guanine nucleotide exchange factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARFGEF2 mRNA

NCBI chr 3:175,966,575...176,052,715
Ensembl chr 3:175,966,579...176,052,713

G

arginase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375

G

Rho GTPase activating protein 27

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARHGAP27 mRNA

NCBI chr10:88,780,527...88,813,275
Ensembl chr10:88,780,527...88,814,616

G

Rho guanine nucleotide exchange factor 7

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARHGEF7 mRNA

NCBI chr16:84,373,123...84,484,759
Ensembl chr16:84,373,123...84,484,597

G

Cdc42 guanine nucleotide exchange factor 9

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ARHGEF9 mRNA

NCBI chr X:63,929,168...64,087,267
Ensembl chr X:63,929,176...64,087,104

G

AT-rich interaction domain 1A

increases expression

ISO

Zinc deficiency results in increased expression of ARID1A mRNA

NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:151,192,014...151,265,386

G

AT-rich interaction domain 3A

increases expression

ISO

Zinc deficiency results in increased expression of ARID3A mRNA

NCBI chr 7:10,403,161...10,431,551
Ensembl chr 7:10,405,631...10,427,926

G

AT-rich interaction domain 4B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARID4B mRNA

NCBI chr17:55,833,908...55,958,382
Ensembl chr17:55,833,908...55,958,382

G

ariadne RBR E3 ubiquitin protein ligase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARIH1 mRNA

NCBI chr 8:68,673,199...68,775,648
Ensembl chr 8:68,673,200...68,775,572

G

arkadia (RNF111) N-terminal like PKA signaling regulator 2N

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARK2N mRNA

NCBI chr18:73,431,104...73,520,759
Ensembl chr18:73,431,104...73,518,144

G

ARF like GTPase 14

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARL14 mRNA

NCBI chr 2:155,778,826...155,780,065
Ensembl chr 2:155,778,826...155,780,065

G

ARF like GTPase 14 effector protein

decreases expression

ISO

Zinc deficiency results in decreased expression of ARL14EP mRNA

NCBI chr 3:113,896,731...113,908,994
Ensembl chr 3:113,898,076...113,908,833

G

ARF like GTPase 4C

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ARL4C mRNA

NCBI chr 9:96,748,075...96,751,510
Ensembl chr 9:96,745,069...96,752,772

G

ARF like GTPase 5B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARL5B mRNA

NCBI chr17:82,864,315...82,888,458
Ensembl chr17:82,864,287...82,890,646

G

ARF like GTPase 6 interacting protein 5

decreases expression

ISO

Zinc deficiency results in decreased expression of ARL6IP5 mRNA

NCBI chr 4:131,365,320...131,395,311
Ensembl chr 4:131,367,289...131,400,130

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
decreases localization

ISO

[Zinc results in decreased localization of ARNT protein] inhibits the reaction [ARNT protein binds to HIF1A protein]; [Zinc results in increased expression of HIF1A mRNA alternative form] which results in decreased localization of ARNT protein; Zinc inhibits the reaction [ARNT protein binds to HIF1A protein]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

actin related protein 2/3 complex, subunit 5-like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARPC5L mRNA

NCBI chr 3:43,169,518...43,177,224
Ensembl chr 3:43,169,462...43,177,240
Ensembl chr 9:43,169,462...43,177,240

G

cAMP-regulated phosphoprotein 19

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARPP19 mRNA

NCBI chr 8:84,660,166...84,683,012
Ensembl chr 8:119,691,942...119,692,385
Ensembl chr 8:119,691,942...119,692,385

G

arrestin, beta 2

affects localization

ISO

Zinc affects the localization of ARRB2 protein

NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487

G

arrestin domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ARRDC2 mRNA

NCBI chr16:18,635,883...18,640,019
Ensembl chr16:18,635,883...18,640,158

G

ADP-ribosyltransferase 1

decreases expression

EXP

Zinc results in decreased expression of ART1 mRNA

NCBI chr 1:165,890,032...165,899,154
Ensembl chr 1:165,890,086...165,899,146

G

ADP-ribosyltransferase 3

increases expression

EXP

Zinc results in increased expression of ART3 mRNA

NCBI chr14:15,921,540...16,003,764
Ensembl chr14:15,921,395...15,949,806

G

N-acylsphingosine amidohydrolase 2

increases expression

EXP

Zinc deficiency results in increased expression of ASAH2 mRNA

NCBI chr 1:239,278,994...239,386,598
Ensembl chr 1:239,278,994...239,382,024

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ASAP1 mRNA

NCBI chr 7:97,675,354...97,982,523
Ensembl chr 7:97,675,354...97,982,024

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

increases expression

ISO

Zinc deficiency results in increased expression of ASAP3 mRNA

NCBI chr 5:153,716,988...153,757,787
Ensembl chr 5:153,716,988...153,757,787

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartoacylase

affects binding

ISO
EXP

Zinc binds to ASPA protein

PMID:17027983 PMID:17194761

NCBI chr10:58,390,204...58,443,790
Ensembl chr10:58,379,410...58,443,769

G

asparaginase

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of ASPG mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of ASPG mRNA]

NCBI chr 6:136,997,832...137,017,417
Ensembl chr 6:136,998,023...137,017,417

G

argininosuccinate synthase 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ASS1 mRNA

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

activating transcription factor 2

multiple interactions

ISO

[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein]

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

activating transcription factor 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 5

affects expression
multiple interactions

ISO

Zinc affects the expression of ATF5 mRNA
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

activating transcription factor 7 interacting protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATF7IP mRNA

NCBI chr 4:171,117,122...171,202,871
Ensembl chr 4:171,117,122...171,202,867

G

autophagy related 101

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATG101 mRNA

NCBI chr 7:134,277,223...134,286,387
Ensembl chr 7:134,272,847...134,286,379

G

autophagy related 12

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATG12 mRNA

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261

G

autophagy related 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATG5 mRNA

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

ATM serine/threonine kinase

decreases expression

ISO

Zinc results in decreased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

atos homolog A

multiple interactions
decreases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in decreased expression of ATOSA mRNA]

NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:84,575,370...84,653,091

G

ATPase Na+/K+ transporting subunit alpha 1

increases expression

EXP

Zinc deficiency results in increased expression of ATP1A1 mRNA

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

ISO

Zinc deficiency results in decreased expression of ATP1A3 mRNA

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

decreases expression

EXP

Zinc deficiency results in decreased expression of ATP2A1 mRNA

NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:190,457,198...190,475,423

G

ATPase secretory pathway Ca2+ transporting 1

increases expression

EXP

Zinc results in increased expression of ATP2C1 mRNA

NCBI chr 8:114,913,551...115,034,706
Ensembl chr 8:114,913,415...115,038,826

G

ATP synthase F1 subunit alpha

decreases expression

EXP

Zinc deficiency results in decreased expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATP synthase peripheral stalk subunit d

decreases expression

EXP

Zinc deficiency results in decreased expression of ATP5PD mRNA

NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954

G

ATP synthase peripheral stalk subunit OSCP

increases expression

EXP

Zinc deficiency results in increased expression of ATP5PO mRNA

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:44,651,173...44,657,520

G

ATPase H+ transporting V1 subunit C1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ATP6V1C1 mRNA

NCBI chr 7:71,719,326...71,757,191
Ensembl chr 7:71,719,404...71,757,184

G

ATPase copper transporting beta

increases abundance

ISO

ATP7B gene mutant form results in increased abundance of Zinc

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

ataxin 3

affects folding
multiple interactions

ISO

Zinc affects the folding of ATXN3 protein polymorphism
Zinc promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism]

NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:126,839,327...126,872,781

G

aurora kinase A

increases expression

ISO

Zinc deficiency results in increased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

aurora kinase B

increases expression

ISO

Zinc deficiency results in increased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

AVL9 cell migration associated

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AVL9 mRNA

NCBI chr 4:87,291,062...87,338,537
Ensembl chr 4:87,291,798...87,331,916

G

arginine vasopressin-induced 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AVPI1 mRNA

NCBI chr 1:250,879,530...250,885,448
Ensembl chr 1:250,879,530...250,885,704

G

antizyme inhibitor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of AZIN1 mRNA

NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:71,539,711...71,566,515

G

beta-1,3-glucuronyltransferase 1

increases expression
decreases expression

ISO
EXP

Zinc deficiency results in increased expression of B3GAT1 mRNA
Zinc deficiency results in decreased expression of B3GAT1 protein

PMID:18224284 PMID:18356318

NCBI chr 8:33,362,791...33,390,446
Ensembl chr 8:33,363,048...33,390,443

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of B3GNT2 mRNA

NCBI chr14:101,009,682...101,034,507
Ensembl chr14:100,967,131...101,043,412

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of B3GNT5 mRNA

NCBI chr11:94,645,480...94,657,584
Ensembl chr11:94,645,480...94,660,514

G

BAG cochaperone 1

decreases expression

ISO

Zinc results in decreased expression of BAG1 mRNA

NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:60,864,476...60,878,161

G

BAG cochaperone 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BAG2 mRNA

NCBI chr 9:43,465,993...43,476,637
Ensembl chr 9:43,465,995...43,476,752

G

BAG cochaperone 3

increases expression
multiple interactions

ISO

Zinc results in increased expression of BAG3 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of BAG3 mRNA

PMID:16870260 PMID:18593933

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BAG cochaperone 5

increases expression

ISO

Zinc deficiency results in increased expression of BAG5 mRNA

NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:136,584,741...136,598,492

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BAIAP2 mRNA

NCBI chr10:105,721,371...105,788,549
Ensembl chr10:105,721,417...105,788,549

G

Btg3 associated nuclear protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BANP mRNA

NCBI chr19:66,916,417...66,994,286
Ensembl chr19:66,916,267...66,991,317

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO
EXP

Zinc results in increased expression of BAX mRNA; Zinc results in increased expression of BAX protein
Zinc inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Zinc inhibits the reaction [Streptozocin results in increased expression of BAX protein]
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]]
Zinc deficiency results in increased expression of BAX protein

PMID:12107073 PMID:15880691 PMID:19887557 PMID:20101602 PMID:29115570 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bardet-Biedl syndrome 10

decreases expression

ISO

Zinc deficiency results in decreased expression of BBS10 mRNA

NCBI chr 7:48,637,324...48,640,395
Ensembl chr 7:48,637,356...48,640,391

G

BCAS2, pre-mRNA processing factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BCAS2 mRNA

NCBI chr 2:193,381,000...193,388,881
Ensembl chr 2:193,380,982...193,388,878

G

BCL10, immune signaling adaptor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BCL10 mRNA

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:237,501,134...237,511,829

G

BCL2, apoptosis regulator

multiple interactions
affects expression
decreases expression
increases expression

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of BCL2 mRNA; [Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]
Zinc affects the expression of BCL2 mRNA
Zinc results in increased expression of BCL2 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Zinc results in increased expression of BCL2 protein]; Metipranolol inhibits the reaction [Zinc results in increased expression of BCL2 protein]; Zinc inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Zinc inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
Zinc deficiency results in decreased expression of BCL2 protein; Zinc results in decreased expression of BCL2 protein

PMID:12107073 PMID:16472982 PMID:16799065 PMID:16979875 PMID:17029595 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

decreases expression
multiple interactions
increases expression

ISO
EXP

Zinc results in decreased expression of BCL2L1 protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]
Zinc results in increased expression of BCL2L1 mRNA

PMID:16472982 PMID:17074742 PMID:19887557

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

ISO

Zinc results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

Bcl2-like 13

decreases expression

ISO

Zinc deficiency results in decreased expression of BCL2L13 mRNA

NCBI chr 4:155,728,284...155,785,058
Ensembl chr 4:155,728,284...155,781,158

G

Bcl2-like 15

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BCL2L15 mRNA

NCBI chr 2:194,019,158...194,032,516
Ensembl chr 2:194,027,397...194,032,516

G

BCL3, transcription coactivator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BCL3 mRNA

NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368

G

BAF chromatin remodeling complex subunit BCL7A

decreases expression

ISO

Zinc deficiency results in decreased expression of BCL7A mRNA

NCBI chr12:38,872,851...38,904,770
Ensembl chr12:38,872,851...38,904,770

G

BCR activator of RhoGEF and GTPase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BCR mRNA

NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,468,732...13,596,333

G

3-hydroxybutyrate dehydrogenase 1

increases expression

EXP

Zinc deficiency results in increased expression of BDH1 mRNA

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

bradykinin receptor B1

affects binding
multiple interactions

ISO

Zinc binds to BDKRB1 protein
Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein]

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973

G

bradykinin receptor B2

increases expression

EXP

Zinc deficiency results in increased expression of BDKRB2 mRNA

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

brain-derived neurotrophic factor

multiple interactions
increases expression

ISO

4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of BDNF mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of BDNF protein]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of BDNF mRNA]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of BDNF protein]; BDNF protein affects the reaction [Zinc results in increased expression of PLAT mRNA]; BDNF protein affects the reaction [Zinc results in increased expression of PLAT protein]; BDNF protein affects the reaction [Zinc results in increased expression of PLG mRNA]; BDNF protein affects the reaction [Zinc results in increased expression of PLG protein]; Zinc results in increased expression of and results in increased secretion of BDNF protein
Zinc deficiency results in increased expression of BDNF protein; Zinc results in increased expression of BDNF mRNA

PMID:20101602 PMID:21615740

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

brain expressed X-linked 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BEX2 mRNA

NCBI chr X:104,010,639...104,012,143
Ensembl chr X:104,010,371...104,011,236

G

bone gamma-carboxyglutamate protein

multiple interactions
decreases expression

ISO
EXP

[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA; Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]
Zinc deficiency results in decreased expression of BGLAP mRNA; Zinc deficiency results in decreased expression of BGLAP protein
Zinc results in decreased expression of BGLAP protein

PMID:17203194 PMID:21893222 PMID:22228435

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

betaine-homocysteine S-methyltransferase

increases expression

EXP

Zinc deficiency results in increased expression of BHMT mRNA

NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:26,594,854...26,614,715

G

BICD cargo adaptor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BICD1 mRNA

NCBI chr 4:184,208,891...184,362,840
Ensembl chr 4:184,210,363...184,357,391

G

BCL2-interacting killer

increases expression

ISO

Zinc deficiency results in increased expression of BIK mRNA

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

baculoviral IAP repeat-containing 3

decreases expression

ISO

Zinc results in decreased expression of BIRC3 protein

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

increases expression

ISO

Zinc deficiency results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BLK proto-oncogene, Src family tyrosine kinase

increases expression

ISO

Zinc results in increased expression of BLK mRNA

NCBI chr15:41,802,701...41,841,004
Ensembl chr15:41,802,994...41,840,982

G

bleomycin hydrolase

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of BLMH mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of BLMH mRNA]

NCBI chr10:62,270,170...62,313,349
Ensembl chr10:62,270,033...62,313,345

G

basic helix-loop-helix ARNT like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

ISO

Zinc deficiency results in decreased expression of BMI1 mRNA

NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024

G

bone morphogenetic protein 8b

increases expression

ISO

Zinc deficiency results in increased expression of BMP8B mRNA

NCBI chr 5:140,671,117...140,696,450
Ensembl chr 5:140,671,211...140,696,448

G

BCL2 interacting protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BNIP2 mRNA

NCBI chr 8:79,521,375...79,539,148
Ensembl chr 8:79,521,363...79,547,368

G

BPI fold containing family B, member 1

increases expression

ISO

Zinc deficiency results in increased expression of BPIFB1 mRNA

NCBI chr 3:163,133,151...163,166,420
Ensembl chr 3:163,133,151...163,166,419

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BRAF mRNA

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931

G

BRCA1 associated protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BRAP mRNA

NCBI chr12:40,535,232...40,561,726
Ensembl chr12:40,535,232...40,561,726

G

BRCA1, DNA repair associated

multiple interactions
affects binding

ISO

sodium arsenite inhibits the reaction [Zinc binds to BRCA1 protein]

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BRCA2, DNA repair associated

decreases expression

ISO

Zinc deficiency results in decreased expression of BRCA2 mRNA

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194

G

bromodomain containing 8

decreases expression

ISO

Zinc deficiency results in decreased expression of BRD8 mRNA

NCBI chr18:26,455,824...26,504,106
Ensembl chr18:26,455,512...26,504,006

G

BRICK1 subunit of SCAR/WAVE actin nucleating complex

decreases expression

ISO

Zinc deficiency results in decreased expression of BRK1 mRNA

NCBI chr 4:148,306,436...148,321,668
Ensembl chr 4:148,306,398...148,321,984

G

basigin

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BSG protein]

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005

G

B-TFIID TATA-box binding protein associated factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BTAF1 mRNA

NCBI chr 1:244,065,728...244,156,457
Ensembl chr 1:244,065,743...244,156,457

G

BTB domain containing 2

affects expression

ISO

Zinc affects the expression of BTBD2 mRNA

NCBI chr 7:9,710,392...9,726,032
Ensembl chr 7:9,712,269...9,726,032

G

BTG anti-proliferation factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

ISO

Zinc deficiency results in increased expression of BUB1 mRNA; Zinc results in increased expression of BUB1 mRNA

PMID:18316168 PMID:22171008

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

similar to human chromosome 17 open reading frame 67

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C17ORF67 mRNA

NCBI chr10:74,392,541...74,413,323
Ensembl chr10:74,392,541...74,413,323

G

similar to human chromosome 21 open reading frame 91

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C21ORF91 mRNA

NCBI chr11:30,716,034...30,749,292
Ensembl chr11:30,716,034...30,749,415

G

similar to human chromosome 9 open reading frame 85

decreases expression

ISO

Zinc deficiency results in decreased expression of C9ORF85 mRNA

NCBI chr 1:228,562,621...228,624,472
Ensembl chr 1:228,564,731...228,624,278

G

complement C1q B chain

increases expression
affects binding

ISO

Zinc deficiency results in increased expression of C1QB mRNA
C1QB protein binds to Zinc

PMID:22171008 PMID:23896426

NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840

G

complement C1q C chain

affects binding

ISO

C1QC protein binds to Zinc

NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:154,410,848...154,414,468

G

complement C1r

affects binding

ISO

C1R protein binds to Zinc

NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:159,098,918...159,109,714

G

complement C1s

affects binding

ISO

C1S protein binds to Zinc

NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736

G

similar to human chromosome 1 open reading frame 52

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C1ORF52 mRNA
Zinc deficiency results in decreased expression of C1ORF52 mRNA

PMID:18593933 PMID:22171008

NCBI chr 2:237,510,974...237,520,346
Ensembl chr 2:237,513,711...237,520,346

G

complement C3

affects binding

ISO

C3 protein binds to Zinc

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

similar to human chromosome 11 open reading frame 96

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C11ORF96 mRNA

NCBI chr 3:100,375,474...100,376,717
Ensembl chr 3:100,351,199...100,378,346

G

similar to human chromosome 9 open reading frame 78

decreases expression

ISO

Zinc deficiency results in decreased expression of C9ORF78 mRNA

NCBI chr 3:34,662,011...34,670,282
Ensembl chr 3:34,661,630...34,670,282

G

complement C4B

affects binding

ISO

C4B protein binds to Zinc

NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289

G

complement component 4 binding protein, alpha

affects binding

ISO

C4BPA protein binds to Zinc

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:44,627,982...44,663,471

G

complement component 4 binding protein, beta

affects binding

ISO

C4BPB protein binds to Zinc

NCBI chr13:44,673,064...44,683,781
Ensembl chr13:44,673,065...44,683,793

G

similar to human chromosome 2 open reading frame 42

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C2ORF42 mRNA

NCBI chr 4:120,445,032...120,474,227
Ensembl chr 4:120,445,830...120,474,396

G

complement C5

affects binding

ISO

C5 protein binds to Zinc

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

complement C5a receptor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C5AR1 mRNA

NCBI chr 1:86,077,309...86,088,001

G

complement C6

affects binding

ISO

C6 protein binds to Zinc

NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120

G

complement C7

decreases expression

ISO

Zinc deficiency results in decreased expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672

G

complement C8 alpha chain

affects binding

ISO

C8A protein binds to Zinc

NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:124,812,131...124,866,710

G

complement C8 beta chain

affects binding

ISO

C8B protein binds to Zinc

NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:124,761,790...124,801,516

G

complement C8 gamma chain

affects binding

ISO

C8G protein binds to Zinc

NCBI chr 3:28,718,648...28,720,232

G

similar to human chromosome 15 open reading frame 39

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of C15ORF39 mRNA

NCBI chr 8:66,542,269...66,551,835
Ensembl chr 8:66,542,269...66,554,782

G

carbonic anhydrase 1

affects abundance

ISO

CA1 gene SNP affects the abundance of Zinc

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

carbonic anhydrase 14

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CA14 mRNA

NCBI chr 2:186,131,196...186,138,164
Ensembl chr 2:186,129,341...186,138,863

G

carbonic anhydrase 5A

decreases expression

ISO

Zinc deficiency results in decreased expression of CA5A mRNA

NCBI chr19:66,881,678...66,911,486
Ensembl chr19:66,881,693...66,911,486

G

calcium voltage-gated channel subunit alpha1 C

increases expression

EXP

Zinc results in increased expression of CACNA1C mRNA

PMID:15159208 PMID:17074742

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762

G

calcium voltage-gated channel subunit alpha1 H

increases expression

ISO

Zinc deficiency results in increased expression of CACNA1H protein

NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771

G

calcyclin binding protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CACYBP mRNA

NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505

G

cell adhesion molecule 1

decreases expression

ISO

Zinc deficiency results in decreased expression of CADM1 mRNA

NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:56,744,372...57,080,192

G

calcium dependent secretion activator

increases expression

EXP

Zinc results in increased expression of CADPS mRNA

NCBI chr15:14,719,078...15,173,218
Ensembl chr15:14,720,726...15,173,211

G

calcitonin-related polypeptide alpha

increases expression

EXP

Zinc deficiency results in increased expression of CALCA mRNA

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

caldesmon 1

increases expression

ISO

Zinc results in increased expression of CALD1 mRNA

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

calmodulin 1

decreases expression

EXP

Zinc results in decreased expression of CALM1 mRNA

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calmodulin 3

decreases expression

EXP

Zinc results in decreased expression of CALM3 mRNA

NCBI chr 1:86,718,761...86,725,869
Ensembl chr 1:86,717,321...86,725,960

G

calreticulin

increases expression

EXP

Zinc results in increased expression of CALR mRNA

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

calcium/calmodulin-dependent protein kinase IG

increases expression

ISO

Zinc deficiency results in increased expression of CAMK1G mRNA

NCBI chr13:107,406,583...107,430,332
Ensembl chr13:107,406,584...107,430,230

G

calmodulin regulated spectrin-associated protein family, member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CAMSAP2 mRNA

NCBI chr13:50,274,950...50,354,298
Ensembl chr13:50,274,950...50,354,298

G

calmodulin binding transcription activator 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CAMTA1 mRNA

NCBI chr 5:166,791,639...167,639,502
Ensembl chr 5:166,793,101...167,639,733

G

calcium activated nucleotidase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CANT1 mRNA

NCBI chr10:104,135,676...104,148,854
Ensembl chr10:104,135,682...104,148,698

G

calpain 11

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CAPN11 mRNA
Zinc deficiency results in increased expression of CAPN11 mRNA

PMID:16979875 PMID:22171008

NCBI chr 9:22,841,500...22,863,042
Ensembl chr 9:22,841,522...22,863,032

G

calpain 6

increases expression

ISO

Zinc deficiency results in increased expression of CAPN6 mRNA

NCBI chr X:112,177,467...112,202,178
Ensembl chr X:112,177,467...112,202,178

G

calpain 9

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CAPN9 mRNA

NCBI chr19:69,446,847...69,483,810
Ensembl chr19:69,446,847...69,483,810

G

carbonic anhydrase 2

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of CA2 mRNA; Zinc deficiency results in increased expression of CAR2 mRNA; Zinc deficiency results in increased expression of CAR2 protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of CAR2 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of CAR2 protein]
[PCI 5002 co-treated with Zinc] results in increased expression of CA2 mRNA

PMID:16140947 PMID:18593933 PMID:19111725

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

cysteinyl-tRNA synthetase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

caspase 1

multiple interactions

ISO

[Ditiocarb co-treated with Zinc] results in decreased expression of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

increases expression

EXP

Zinc deficiency results in increased expression of CASP12 mRNA

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

multiple interactions
decreases expression
decreases activity
increases cleavage

ISO
EXP

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Zinc results in increased cleavage of CASP3 protein]; [Dopamine co-treated with Zinc deficiency] results in increased activity of CASP3 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein]; Metipranolol inhibits the reaction [Zinc results in increased cleavage of CASP3 protein]; SM-1 compound inhibits the reaction [Zinc results in decreased activity of CASP3 protein]; Zinc affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]; Zinc results in increased cleavage of and results in increased activity of CASP3 protein
Zinc results in decreased expression of CASP3 protein
Zinc results in decreased expression of CASP3 mRNA
[Rutin binds to Zinc] which results in increased expression of CASP3 mRNA; Zinc deficiency results in increased expression of and results in increased cleavage of CASP3 protein; Zinc inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Zinc results in increased cleavage of CASP3 protein]; [Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in increased expression of CASP3 mRNA]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]; Metipranolol inhibits the reaction [Zinc results in increased cleavage of CASP3 protein]; Paraquat promotes the reaction [Zinc results in decreased expression of CASP3 protein]; Zinc affects the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; Zinc promotes the reaction [Paraquat results in decreased expression of CASP3 protein]

PMID:12107073 PMID:15966574 PMID:16472982 PMID:16799065 PMID:19887557 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

[Rutin binds to Zinc] which results in increased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
decreases expression

ISO
EXP

[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; [PCI 5002 co-treated with Zinc] results in increased expression of CASP9 mRNA; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein]
Zinc results in decreased expression of CASP9 protein
[Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]]; Paraquat promotes the reaction [Zinc results in decreased expression of CASP9 protein]; Zinc affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; Zinc promotes the reaction [Paraquat results in decreased expression of CASP9 protein]

PMID:18593933 PMID:24184500 PMID:29115570 PMID:32060784

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity
decreases expression
affects expression

EXP
ISO

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of CAT protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of CAT protein]; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CAT protein]; [Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; [Zinc co-treated with Vitamin E co-treated with Ascorbic Acid co-treated with sodium arsenite] results in increased activity of CAT protein; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of CAT protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; [Zinc Sulfate results in increased abundance of Zinc] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Zinc results in decreased expression of CAT protein]; Zinc affects the reaction [sodium arsenite results in decreased activity of CAT protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; Zinc inhibits the reaction [FOXO1 protein results in increased expression of CAT protein]; Zinc inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Zinc inhibits the reaction [nickel sulfate results in increased activity of CAT protein]; Zinc inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CAT protein inhibits the reaction [Zinc results in increased abundance of Hydrogen Peroxide]; CAT protein inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]
Zinc deficiency results in decreased activity of CAT protein; Zinc results in decreased activity of CAT protein
[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]; [Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]; Zinc deficiency promotes the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Zinc inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Zinc inhibits the reaction [Ethanol results in decreased activity of CAT protein]
Zinc deficiency results in decreased expression of CAT mRNA; Zinc results in decreased expression of CAT protein
Zinc affects the expression of CAT protein

PMID:9330853 PMID:10381190 PMID:10938463 PMID:12566098 PMID:15535990 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolae associated protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CAVIN1 mRNA

NCBI chr10:86,384,401...86,398,240
Ensembl chr10:86,384,401...86,396,383

G

cobalamin binding intrinsic factor

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CBLIF mRNA

NCBI chr 1:218,030,756...218,045,004
Ensembl chr 1:218,030,731...218,045,117

G

chromobox 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CBX4 mRNA

NCBI chr10:104,835,685...104,841,727
Ensembl chr10:104,835,685...104,841,727

G

coiled-coil domain containing 93

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCDC93 mRNA

NCBI chr13:35,160,354...35,233,877
Ensembl chr13:35,160,363...35,233,875

G

C-C motif chemokine ligand 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCL1 mRNA

NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790

G

C-C motif chemokine ligand 17

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]

NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895

G

C-C motif chemokine ligand 19

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]

NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022

G

C-C motif chemokine ligand 2

multiple interactions
increases expression
decreases expression

ISO

IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL2 protein]; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of CCL2 protein]
Zinc deficiency results in increased expression of CCL2 mRNA
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of CCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA]

PMID:18215484 PMID:20427734 PMID:21035309 PMID:23503329 PMID:30635848

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of CCL20 mRNA
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]
[PCI 5002 co-treated with Zinc] results in increased expression of CCL20 mRNA

PMID:11717422 PMID:18593933 PMID:23503329

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 24

increases expression
multiple interactions

ISO

Zinc deficiency results in increased expression of CCL24 mRNA
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL24 mRNA

PMID:18356318 PMID:23503329

NCBI chr12:26,737,423...26,741,420
Ensembl chr12:26,737,439...26,750,924

G

C-C motif chemokine ligand 25

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL25 mRNA

NCBI chr12:7,505,231...7,514,402
Ensembl chr12:7,505,235...7,514,385

G

C-C motif chemokine ligand 26

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCL26 mRNA

NCBI chr12:26,745,972...26,750,924

G

C-C motif chemokine ligand 27

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL27 mRNA

NCBI chr 5:61,737,261...61,744,375
Ensembl chr 5:61,737,261...61,743,522

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[Zinc deficiency co-treated with Ethanol] results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL5 mRNA

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine ligand 7

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL7 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL7 mRNA]

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

C-C motif chemokine ligand 9

increases expression

EXP

Zinc deficiency results in increased expression of CCL6 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877

G

cellular communication network factor 2

multiple interactions

ISO
EXP

Zinc inhibits the reaction [Glucose results in increased expression of CCN2 protein]
Zinc inhibits the reaction [Dietary Fats results in increased expression of CCN2 protein]
Zinc inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:19369054 PMID:27370414

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin A2

increases expression

ISO

Zinc deficiency results in increased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of CCNB1 mRNA; Zinc deficiency results in increased expression of CCNB1 protein
[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCNB1 protein]
Zinc inhibits the reaction [Zinc deficiency results in increased expression of CCNB1 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of CCNB1 protein]

PMID:16140947 PMID:36162444

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B1 interacting protein 1

decreases expression

ISO

Zinc deficiency results in decreased expression of CCNB1IP1 mRNA

NCBI chr15:26,488,462...26,504,167
Ensembl chr15:26,488,465...26,502,028

G

cyclin B2

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCNB2 mRNA
Zinc deficiency results in increased expression of CCNB2 mRNA

PMID:16979875 PMID:22171008

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

decreases expression
increases expression
multiple interactions

EXP
ISO

Zinc results in decreased expression of CCND1 mRNA
Zinc results in increased expression of CCND1 mRNA
[Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of CCND1 protein]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of CCND1 protein]]
Zinc deficiency results in decreased expression of CCND1 protein; Zinc results in decreased expression of CCND1 protein
Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]; Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]

PMID:17074742 PMID:19071009 PMID:19913001 PMID:20857495 PMID:21600978 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

decreases expression

EXP

Zinc results in decreased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin E1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCNE1 mRNA

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin E2

decreases expression

ISO

Zinc results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin L1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCNL1 mRNA

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:152,495,172...152,507,468

G

cyclin T1

increases expression

ISO

Zinc deficiency results in increased expression of CCNT1 mRNA

NCBI chr 7:131,566,176...131,596,988
Ensembl chr 7:131,566,176...131,596,938

G

C-C motif chemokine receptor 9

increases expression

ISO

Zinc deficiency results in increased expression of CCR9 mRNA

NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:132,273,544...132,287,883

G

copper chaperone for superoxide dismutase

affects binding
multiple interactions

ISO
EXP

Zinc binds to CCS protein
[Copper deficiency co-treated with Zinc] results in increased expression of CCS

PMID:15736924 PMID:18820153

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260

G

coiled-coil serine-rich protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCSER2 mRNA

NCBI chr16:12,633,374...12,746,045
Ensembl chr16:12,637,083...12,746,003

G

chaperonin containing TCP1 subunit 6A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CCT6A mRNA

NCBI chr12:32,508,842...32,519,072
Ensembl chr12:32,508,675...32,519,119

G

chaperonin containing TCP1 subunit 7

decreases expression

ISO

Zinc results in decreased expression of CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

CD14 molecule

multiple interactions

ISO

[Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD160 molecule

decreases expression

ISO

Zinc deficiency results in decreased expression of CD160 mRNA

NCBI chr 2:187,029,654...187,042,447
Ensembl chr 2:187,033,140...187,064,587

G

CD22 molecule

increases expression

ISO

Zinc results in increased expression of CD22 mRNA

NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:95,244,868...95,259,730

G

CD226 molecule

decreases expression

ISO

Zinc deficiency results in decreased expression of CD226 mRNA

NCBI chr18:84,723,330...84,819,836
Ensembl chr18:84,725,242...84,819,835

G

CD24 molecule

increases expression

EXP

Zinc deficiency results in increased expression of CD24 mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

CD36 molecule

multiple interactions
decreases expression
increases expression

ISO
EXP

[Zinc deficiency co-treated with Ethanol] results in increased expression of CD36 mRNA
Zinc deficiency results in decreased expression of CD36 mRNA
Zinc results in increased expression of CD36 mRNA

PMID:17074742 PMID:24155903

NCBI chr 4:18,209,088...18,302,142

G

CD38 molecule

increases expression

ISO

Zinc deficiency results in increased expression of CD38 mRNA

NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505

G

CD3 gamma subunit of T-cell receptor complex

increases expression

EXP

Zinc deficiency results in increased expression of CD3G mRNA

NCBI chr 8:54,177,572...54,184,087
Ensembl chr 8:54,177,977...54,183,918

G

Cd4 molecule

multiple interactions
increases expression

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD4 mRNA
Zinc deficiency results in increased expression of CD4 mRNA

PMID:11717422 PMID:16979875

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461

G

CD40 molecule

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD40 mRNA

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

CD55 molecule (Cromer blood group)

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CD55 mRNA

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

CD9 molecule

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD9 mRNA
Zinc results in increased expression of CD9 mRNA

PMID:16870260 PMID:16979875

NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444

G

cell division cycle 20

multiple interactions
decreases expression
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDC20 mRNA
Zinc deficiency results in decreased expression of CDC20 mRNA
Zinc deficiency results in increased expression of CDC20 mRNA

PMID:12888634 PMID:16979875 PMID:22171008

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 25A

increases expression

ISO

Zinc deficiency results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

CDC42 binding protein kinase beta

affects expression

ISO

Zinc affects the expression of CDC42BPB mRNA

NCBI chr 6:136,154,905...136,241,259
Ensembl chr 6:136,154,905...136,237,570

G

CDC42 effector protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CDC42EP2 mRNA

NCBI chr 1:212,631,317...212,640,231
Ensembl chr 1:212,629,881...212,640,234

G

CDC42 effector protein 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CDC42EP3 mRNA

NCBI chr 6:21,463,081...21,483,553
Ensembl chr 6:21,461,762...21,508,540

G

cell division cycle 45

increases expression

ISO

Zinc deficiency results in increased expression of CDC45 mRNA

NCBI chr11:95,689,702...95,714,980
Ensembl chr11:95,689,919...95,714,981

G

cell division cycle associated 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CDCA4 mRNA

NCBI chr 6:137,713,390...137,722,652
Ensembl chr 6:137,713,051...137,722,580

G

cell division cycle associated 5

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CDCA5 mRNA
Zinc deficiency results in increased expression of CDCA5 mRNA

PMID:18593933 PMID:22171008

NCBI chr 1:212,807,863...212,821,313
Ensembl chr 1:212,804,014...212,821,309

G

cell division cycle associated 8

increases expression

ISO

Zinc deficiency results in increased expression of CDCA8 mRNA

NCBI chr 5:142,461,082...142,483,336
Ensembl chr 5:142,461,084...142,483,283

G

cadherin 1

multiple interactions
increases expression

ISO

Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]
Zinc deficiency results in increased expression of CDH1 mRNA

PMID:16844947 PMID:18356318

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 16

decreases expression

EXP

Zinc deficiency results in decreased expression of CDH16 mRNA

NCBI chr19:367,202...377,710
Ensembl chr19:367,274...388,934

G

cyclin-dependent kinase 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

CDK5 regulatory subunit associated protein 1-like 1

increases expression

ISO

Zinc deficiency results in increased expression of CDKAL1 mRNA

NCBI chr17:34,927,221...35,479,827
Ensembl chr17:34,950,157...35,479,905

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of CDKN1A mRNA; Zinc results in increased expression of CDKN1A mRNA
Zinc results in increased expression of CDKN1A protein
[PCI 5002 co-treated with Zinc] results in increased expression of CDKN1A mRNA
[SLC30A10 protein affects the abundance of Zinc] which affects the expression of CDKN1A protein; [SLC30A3 protein affects the abundance of Zinc] which affects the expression of CDKN1A protein
Zinc results in increased expression of CDKN1A mRNA; Zinc results in increased expression of CDKN1A protein

PMID:12107073 PMID:15880691 PMID:17074742 PMID:18593933 PMID:19111725 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1C

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDKN1C mRNA
Zinc results in increased expression of CDKN1C mRNA

PMID:16979875 PMID:19071009

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498

G

cyclin-dependent kinase inhibitor 2C

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDKN2C mRNA

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891

G

cyclin-dependent kinase inhibitor 3

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of CDKN3 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of CDKN3 mRNA]

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

chromatin licensing and DNA replication factor 1

increases expression

ISO

Zinc deficiency results in increased expression of CDT1 mRNA

NCBI chr19:67,529,249...67,534,195
Ensembl chr19:67,529,201...67,534,194

G

chromodomain Y-like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CDYL mRNA

NCBI chr17:29,188,697...29,409,805
Ensembl chr17:29,188,698...29,409,757

G

CEA cell adhesion molecule 1

increases expression

EXP

Zinc deficiency results in increased expression of CEACAM1 mRNA

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases response to substance

ISO

CEBPA protein inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; CEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]
CEBPA protein results in increased susceptibility to Zinc

PMID:15389791 PMID:17363595

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

multiple interactions
increases expression

EXP

[Thymic Factor, Circulating co-treated with Zinc] results in increased activity of CEBPB protein
Zinc results in increased expression of CEBPB mRNA

PMID:12639846 PMID:17074742

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CCAAT/enhancer binding protein delta

increases expression

EXP

Zinc results in increased expression of CEBPD mRNA

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824

G

CCAAT/enhancer binding protein gamma

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283

G

carboxyl ester lipase

decreases expression

EXP

Zinc deficiency results in decreased expression of CEL mRNA

NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

ISO

Zinc deficiency results in increased expression of CELSR3 mRNA

NCBI chr 8:118,409,136...118,438,593
Ensembl chr 8:118,409,136...118,436,847

G

centromere protein M

increases expression

ISO

Zinc deficiency results in increased expression of CENPM mRNA

NCBI chr 7:115,628,117...115,639,401
Ensembl chr 7:115,628,129...115,643,866

G

centrosomal protein 15

decreases expression

ISO

Zinc results in decreased expression of CEP15 mRNA

NCBI chr15:15,247,627...15,265,560
Ensembl chr15:15,247,932...15,265,475

G

centrosomal protein 20

decreases expression

ISO

Zinc deficiency results in decreased expression of CEP20 mRNA

NCBI chr10:1,221,294...1,243,144
Ensembl chr10:1,221,371...1,245,241

G

centrosomal protein 95

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CEP95 mRNA

NCBI chr10:92,231,829...92,259,813
Ensembl chr10:92,231,512...92,259,810

G

ceramide synthase 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CERS6 mRNA

NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544

G

carboxylesterase 1C

decreases expression
increases expression

EXP

Zinc deficiency results in decreased expression of CES1C mRNA
Zinc deficiency results in increased expression of CES1C mRNA

PMID:15671213 PMID:19111725

NCBI chr19:30,099,383...30,128,531
Ensembl chr19:30,099,323...30,128,528

G

carboxylesterase 1D

decreases expression
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of CES1D mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of CES1D mRNA]

PMID:12672911 PMID:15671213 PMID:16140947 PMID:20857495

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

carboxylesterase 2C

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CES2C mRNA

NCBI chr 1:270,377,201...270,384,768
Ensembl chr 1:270,374,913...270,384,801

G

cilia and flagella associated protein 410

increases expression

ISO

Zinc deficiency results in increased expression of CFAP410 mRNA

NCBI chr20:10,687,506...10,694,366
Ensembl chr20:10,687,506...10,694,366

G

cilia and flagella associated protein 53

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CFAP53 mRNA

NCBI chr18:70,159,900...70,227,543
Ensembl chr18:70,159,898...70,227,540

G

cilia and flagella associated protein 96

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CFAP96 mRNA

NCBI chr16:53,023,623...53,048,176
Ensembl chr16:53,023,878...53,048,965

G

complement factor B

increases expression
affects binding

ISO

Zinc results in increased expression of CFB mRNA
CFB protein binds to Zinc

PMID:15984569 PMID:23896426

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

complement factor H

affects binding

ISO

CFH protein binds to Zinc

NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532

G

complement factor I

increases expression
affects binding

ISO

Zinc deficiency results in increased expression of CFI mRNA
CFI protein binds to Zinc

PMID:20857495 PMID:23896426

NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:221,062,212...221,104,786

G

CF transmembrane conductance regulator

increases expression
multiple interactions

ISO
EXP

Zinc results in increased expression of CFTR mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of CFTR mRNA]

PMID:16870260 PMID:19111725

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

cyclic GMP-AMP synthase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CGAS mRNA

NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:88,174,512...88,185,859

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHAC1 mRNA
Zinc deficiency results in decreased expression of CHAC1 mRNA

PMID:18356318 PMID:18593933

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

chromosome alignment maintaining phosphoprotein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHAMP1 mRNA

NCBI chr16:82,436,172...82,447,144
Ensembl chr16:82,434,823...82,458,984

G

chromodomain helicase DNA binding protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHD2 mRNA

NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:136,599,900...136,710,335

G

charged multivesicular body protein 1B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHMP1B mRNA

NCBI chr18:63,010,270...63,012,800
Ensembl chr18:63,010,251...63,011,415

G

cysteine and histidine rich domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHORDC1 mRNA

NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696

G

chondroitin sulfate synthase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHSY1 mRNA

NCBI chr 1:129,100,088...129,161,167
Ensembl chr 1:129,100,041...129,161,081

G

chromatin target of PRMT1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CHTOP mRNA

NCBI chr 2:178,278,848...178,291,142
Ensembl chr 2:178,278,848...178,290,348

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

capicua transcriptional repressor

increases expression

ISO

Zinc deficiency results in increased expression of CIC mRNA

NCBI chr 1:89,980,660...90,008,357
Ensembl chr 1:89,981,743...90,008,354

G

class II, major histocompatibility complex, transactivator

affects expression

ISO

Zinc affects the expression of CIITA mRNA

NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,647,085...5,694,342

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CITED2 mRNA

NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782

G

cytoskeleton-associated protein 4

increases expression

ISO

Zinc deficiency results in increased expression of CKAP4 mRNA

NCBI chr 7:21,118,527...21,126,624
Ensembl chr 7:21,118,085...21,126,624

G

chemokine-like factor

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA

NCBI chr19:704,528...712,998
Ensembl chr19:697,451...712,998

G

creatine kinase, M-type

decreases expression

EXP

Zinc deficiency results in decreased expression of CKM mRNA

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

CDC28 protein kinase regulatory subunit 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519
Ensembl chr17:13,722,361...13,727,519

G

cytoplasmic linker associated protein 1

increases expression

ISO

Zinc deficiency results in increased expression of CLASP1 mRNA

NCBI chr13:32,046,362...32,267,954
Ensembl chr13:32,046,444...32,267,924

G

cardiotrophin-like cytokine factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CLCF1 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CLCF1 mRNA

PMID:18593933 PMID:33549593

NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:210,937,255...210,947,064

G

chloride voltage-gated channel 3

increases expression

ISO

Zinc deficiency results in increased expression of CLCN3 mRNA

NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984

G

C-type lectin domain family 1, member A

decreases expression

ISO

Zinc deficiency results in decreased expression of CLEC1A mRNA

NCBI chr 4:164,561,385...164,588,593
Ensembl chr 4:164,563,374...164,587,269

G

chloride intracellular channel 4

increases expression

EXP

Zinc deficiency results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

chloride intracellular channel 6

increases expression

ISO

Zinc deficiency results in increased expression of CLIC6 mRNA

NCBI chr11:45,223,715...45,266,261
Ensembl chr11:45,223,669...45,267,344

G

CDC-like kinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CLK1 mRNA

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

CDC-like kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CLK3 mRNA

NCBI chr 8:67,048,121...67,063,192
Ensembl chr 8:67,048,123...67,062,881

G

CLN6, transmembrane ER protein

increases abundance

ISO

CLN6 gene mutant form results in increased abundance of Zinc

NCBI chr 8:72,198,773...72,213,777
Ensembl chr 8:72,198,712...72,213,776

G

CLN8, transmembrane ER and ERGIC protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CLN8 mRNA

NCBI chr16:81,451,941...81,462,046
Ensembl chr16:81,451,944...81,461,832

G

chloride nucleotide-sensitive channel 1A

decreases expression

ISO

Zinc deficiency results in decreased expression of CLNS1A mRNA

NCBI chr 1:161,429,437...161,450,904
Ensembl chr 1:161,421,808...161,450,902

G

colipase

decreases expression

EXP

Zinc deficiency results in decreased expression of CLPS mRNA

NCBI chr20:6,622,234...6,624,414
Ensembl chr20:6,622,231...6,624,505

G

CLPTM1-like

increases expression

ISO

Zinc deficiency results in increased expression of CLPTM1L mRNA

NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:31,496,094...31,512,077

G

clusterin

multiple interactions
affects binding

ISO

Nimodipine inhibits the reaction [Zinc results in increased expression of CLU protein]; SLC30A1 inhibits the reaction [Zinc results in increased expression of and results in increased secretion of CLU protein]; U 0126 inhibits the reaction [Zinc results in increased expression of CLU protein]; wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein]; Zinc results in increased expression of and results in increased secretion of CLU protein
CLU protein binds to Zinc
[PCI 5002 co-treated with Zinc] results in increased expression of CLU mRNA

PMID:18593933 PMID:19288494 PMID:23896426

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cytidine monophospho-N-acetylneuraminic acid hydroxylase

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CMAHP mRNA

NCBI chr17:40,985,129...41,070,317
Ensembl chr17:41,011,641...41,070,252

G

chemerin chemokine-like receptor 1

multiple interactions
decreases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CMKLR1 mRNA
Zinc deficiency results in decreased expression of CMKLR1 mRNA

PMID:16979875 PMID:18356318

NCBI chr12:48,634,929...48,687,833
Ensembl chr12:48,634,003...48,691,458

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression
multiple interactions

ISO

Zinc results in increased expression of CNBP mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of CNBP mRNA

PMID:15226459 PMID:18593933

NCBI chr 4:121,860,102...121,868,976
Ensembl chr 4:121,860,105...121,869,010

G

cyclic nucleotide gated channel subunit beta 1

increases expression

ISO

Zinc deficiency results in increased expression of CNGB1 mRNA

NCBI chr19:9,732,646...9,798,864
Ensembl chr19:9,732,646...9,797,224

G

cyclic nucleotide gated channel subunit beta 3

decreases expression

ISO

Zinc deficiency results in decreased expression of CNGB3 mRNA

NCBI chr 5:37,543,903...37,792,030
Ensembl chr 5:37,543,903...37,792,030

G

Cnksr family member 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CNKSR3 mRNA

NCBI chr 1:45,904,581...45,996,921
Ensembl chr 1:45,904,581...45,996,921

G

calponin 1

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of CNN1 mRNA; Zinc deficiency results in decreased expression of CNN1 protein
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of CNN1 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in decreased expression of CNN1 protein]

NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:28,908,330...28,919,482

G

calponin 3

decreases expression

EXP

Zinc results in decreased expression of CNN3 mRNA

NCBI chr 2:212,203,661...212,234,772
Ensembl chr 2:212,226,640...212,234,815

G

contactin 6

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CNTN6 mRNA

NCBI chr 4:138,911,090...139,307,339
Ensembl chr 4:138,911,380...139,311,816

G

cochlin

decreases expression

ISO

Zinc deficiency results in decreased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502

G

collagen type XVIII alpha 1 chain

increases expression

ISO

Zinc deficiency results in increased expression of COL18A1 mRNA

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collagen type I alpha 1 chain

multiple interactions
decreases expression

ISO
EXP

[Genistein co-treated with Zinc] results in increased expression of COL1A1 mRNA; [Zinc binds to calcium silicate] which results in increased expression of COL1A1 mRNA; Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of COL1A1 mRNA]
Zinc deficiency results in decreased expression of COL1A1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of COL1A1 mRNA]

PMID:16140947 PMID:17203194 PMID:21893222 PMID:23483914

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type III alpha 1 chain

increases expression

ISO

Zinc deficiency results in increased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

collagen type IV alpha 3 chain

multiple interactions

EXP

Zinc inhibits the reaction [Streptozocin results in increased expression of COL4A3 mRNA]

NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:91,323,990...91,453,077

G

collagen type VI alpha 2 chain

decreases expression

ISO

Zinc deficiency results in decreased expression of COL6A2 mRNA

NCBI chr20:12,021,182...12,048,932
Ensembl chr20:12,021,265...12,057,042

G

collagen type VIII alpha 1 chain

decreases expression

ISO

Zinc deficiency results in decreased expression of COL8A1 mRNA

NCBI chr11:56,245,998...56,378,586
Ensembl chr11:56,369,868...56,376,229

G

copper metabolism domain containing 1

increases uptake

EXP

COMMD1 protein results in increased uptake of Zinc

NCBI chr14:101,081,667...101,185,738
Ensembl chr14:101,081,667...101,185,639

G

cartilage oligomeric matrix protein

increases expression

ISO

Zinc deficiency results in increased expression of COMP mRNA

NCBI chr16:19,081,172...19,089,548
Ensembl chr16:19,081,172...19,089,605

G

COPI coat complex subunit gamma 1

increases expression

ISO

Zinc deficiency results in increased expression of COPG1 mRNA

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

coenzyme Q10B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of COQ10B mRNA

NCBI chr 9:64,048,168...64,068,082
Ensembl chr 9:64,048,103...64,068,322

G

coenzyme Q8A

decreases expression

EXP

Zinc deficiency results in decreased expression of COQ8A mRNA

NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378

G

cytochrome c oxidase copper chaperone COX17

decreases expression

EXP

Zinc results in decreased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

cytochrome c oxidase subunit 6A2

decreases expression

EXP

Zinc deficiency results in decreased expression of COX6A2 mRNA

NCBI chr 1:192,218,970...192,221,188
Ensembl chr 1:192,218,970...192,219,716

G

cytochrome c oxidase subunit 7A2 like

decreases expression

ISO

Zinc deficiency results in decreased expression of COX7A2L mRNA

NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:16,936,795...16,950,798

G

cytochrome c oxidase subunit 8A

decreases expression

EXP

Zinc results in decreased expression of COX8A mRNA

NCBI chr 1:213,831,302...213,833,623
Ensembl chr 1:213,831,298...213,833,623

G

cytochrome c oxidase, subunit VIIIb

decreases expression

EXP

Zinc deficiency results in decreased expression of COX8B mRNA

NCBI chr 1:205,406,813...205,408,273
Ensembl chr 1:205,406,813...205,408,311

G

ceruloplasmin

decreases expression
multiple interactions
affects binding
increases expression

EXP
ISO

Zinc deficiency results in decreased expression of CP mRNA
[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]
CP protein binds to Zinc
Zinc deficiency results in increased expression of CP mRNA

PMID:12672911 PMID:22534743 PMID:23896426

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

carboxypeptidase N subunit 1

affects binding

ISO

CPN1 protein binds to Zinc

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

carboxypeptidase N subunit 2

decreases expression
affects binding

ISO

Zinc deficiency results in decreased expression of CPN2 mRNA
CPN2 protein binds to Zinc

PMID:18356318 PMID:23896426

NCBI chr11:83,990,943...84,000,821
Ensembl chr11:83,990,940...84,001,059

G

carboxypeptidase Q

increases expression

ISO

Zinc deficiency results in increased expression of CPQ mRNA

NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137

G

carbamoyl-phosphate synthase 1

increases expression

ISO

Zinc results in increased expression of CPS1 mRNA

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734

G

carnitine palmitoyltransferase 1A

increases expression
multiple interactions
affects expression
decreases expression

EXP
ISO

Zinc results in increased expression of CPT1A mRNA
[Zinc deficiency co-treated with Ethanol] affects the expression of CPT1A mRNA
Zinc deficiency affects the expression of CPT1A mRNA
Zinc deficiency results in decreased expression of CPT1A mRNA

PMID:15671213 PMID:17074742 PMID:24155903

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

cAMP responsive element binding protein 1

multiple interactions
increases activity

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CREB1 mRNA
Zinc deficiency results in increased activity of CREB1 protein

PMID:18356318 PMID:18593933

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

multiple interactions

ISO

Zinc promotes the reaction [MTF1 protein binds to EP300 protein binds to CREBBP protein]

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

CREB3 regulatory factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CREBRF mRNA

NCBI chr10:16,903,607...16,967,450
Ensembl chr10:16,903,547...16,966,430

G

CREB/ATF bZIP transcription factor

decreases expression

ISO

Zinc deficiency results in decreased expression of CREBZF mRNA

NCBI chr 1:153,829,544...153,836,073
Ensembl chr 1:153,829,448...153,845,122

G

cAMP responsive element modulator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

CXXC repeat containing interactor of PDZ3 domain

decreases expression

ISO

Zinc deficiency results in decreased expression of CRIPT mRNA

NCBI chr 6:13,334,978...13,342,934
Ensembl chr 6:13,334,954...13,345,044

G

cysteine-rich secretory protein 1

increases expression

ISO

Zinc deficiency results in increased expression of CRISP1 mRNA

NCBI chr 9:28,238,326...28,265,344
Ensembl chr 9:28,238,328...28,265,344

G

cysteine-rich secretory protein LCCL domain containing 2

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of CRISPLD2 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of CRISPLD2 mRNA

PMID:18593933 PMID:20857495

NCBI chr19:64,961,764...65,020,099
Ensembl chr19:64,961,771...65,020,349

G

ciliary rootlet coiled-coil, rootletin

decreases expression

ISO

Zinc deficiency results in decreased expression of CROCC mRNA

NCBI chr 5:158,603,979...158,646,728
Ensembl chr 5:158,603,556...158,640,238

G

C-reactive protein

affects expression
multiple interactions
decreases expression

ISO

Zinc affects the expression of CRP protein
[Zinc co-treated with Aluminum] results in increased expression of CRP protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of CRP protein
Zinc results in decreased expression of CRP protein

PMID:17018878 PMID:20427734 PMID:27816692

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

cytotoxic and regulatory T cell molecule

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CRTAM mRNA

NCBI chr 8:50,237,210...50,274,472
Ensembl chr 8:50,237,210...50,274,472

G

crystallin, alpha A

decreases expression

ISO

Zinc deficiency results in decreased expression of CRYAA mRNA

PMID:12888634 PMID:18356318

NCBI chr20:9,784,872...9,788,656
Ensembl chr20:9,784,857...9,788,654

G

crystallin, alpha B

decreases expression

EXP

Zinc deficiency results in decreased expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

crystallin zeta

decreases expression

ISO

Zinc deficiency results in decreased expression of CRYZ mRNA

NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:246,211,156...246,239,470

G

citrate synthase

increases expression

EXP

Zinc results in increased expression of CS mRNA

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

colony stimulating factor 1

multiple interactions

ISO

Cycloheximide inhibits the reaction [Zinc results in increased expression of CSF1 mRNA]; MT1 protein affects the reaction [Zinc results in increased expression of CSF1 mRNA]

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

colony stimulating factor 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 2 receptor subunit alpha

decreases expression

ISO

Zinc deficiency results in decreased expression of CSF2RA mRNA

NCBI chr14:113,219...118,808
Ensembl chr14:113,225...118,117

G

colony stimulating factor 3

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CSF3 mRNA

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

casein beta

affects expression

EXP

Zinc affects the expression of CSN2 mRNA

NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,601,824...20,609,060

G

casein kinase 1, delta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CSNK1D mRNA

NCBI chr10:106,713,497...106,754,953
Ensembl chr10:106,694,279...106,754,953

G

casein kinase 1, gamma 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CSNK1G1 mRNA

NCBI chr 8:75,334,751...75,472,339
Ensembl chr 8:75,334,895...75,467,515

G

casein kinase 2 alpha 1

multiple interactions

ISO

2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]; Zinc promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

cysteine and serine rich nuclear protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CSRNP1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:128,582,365...128,588,469

G

cysteine and serine rich nuclear protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CSRNP2 mRNA

NCBI chr 7:133,473,027...133,488,868
Ensembl chr 7:133,473,027...133,488,868

G

cysteine and glycine-rich protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

cysteine and glycine rich protein 3

decreases expression

EXP

Zinc deficiency results in decreased expression of CSRP3 mRNA; Zinc deficiency results in decreased expression of CSRP3 protein

NCBI chr 1:107,664,338...107,682,916
Ensembl chr 1:107,664,338...107,682,916

G

cystathionine gamma-lyase

increases expression

EXP

Zinc deficiency results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

catenin beta 1

multiple interactions

ISO
EXP

Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]
[Zinc co-treated with pyrithione] results in increased cleavage of CTNNB1 protein; Zinc deficiency results in decreased activity of and results in decreased expression of CTNNB1 protein

PMID:16844947 PMID:17098228 PMID:21893222

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin E

increases expression

ISO

Zinc deficiency results in increased expression of CTSE mRNA

NCBI chr13:45,644,168...45,666,722
Ensembl chr13:45,644,147...45,666,722

G

cathepsin H

increases expression

EXP

Zinc deficiency results in increased expression of CTSH mRNA

NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181

G

cathepsin K

decreases activity
decreases expression

EXP

Zinc deficiency results in decreased activity of CTSK protein
Zinc deficiency results in decreased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cathepsin L

decreases expression
increases expression

ISO
EXP

Zinc results in decreased expression of CTSL mRNA
Zinc results in increased expression of CTSL mRNA

PMID:17074742 PMID:18316168

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cortactin

increases expression

EXP

Zinc deficiency results in increased expression of CTTN mRNA

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211

G

cut-like homeobox 1

increases activity

ISO

Zinc deficiency results in increased activity of CUX1 protein

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:25,743,733...26,062,497

G

C-X3-C motif chemokine ligand 1

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

CXADR, Ig-like cell adhesion molecule

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CXADR mRNA

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:30,469,526...30,516,988

G

C-X-C motif chemokine ligand 1

increases expression

EXP

Zinc deficiency results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

multiple interactions
decreases expression

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL10 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of CXCL10 mRNA]; [Zinc deficiency co-treated with Ethanol] results in increased expression of CXCL10 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL10 mRNA]
Zinc deficiency results in decreased expression of CXCL10 mRNA

PMID:23503329 PMID:24155903

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 11

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567

G

C-X-C motif chemokine ligand 12

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of CXCL12 mRNA
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA]

PMID:20857495 PMID:23503329

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 16

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]

NCBI chr10:55,665,355...55,669,950
Ensembl chr10:55,664,742...55,670,226

G

C-X-C motif chemokine ligand 2

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of CXCL2 mRNA
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA]

PMID:22689922 PMID:23503329

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine ligand 6

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CXCL6 mRNA

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417

G

C-X-C motif chemokine ligand 9

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

C-X-C motif chemokine receptor 4

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of CXCR4 mRNA
Zinc deficiency results in increased expression of CXCR4 mRNA

PMID:18593933 PMID:22689922

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

CXXC finger protein 1

increases expression

ISO

Zinc deficiency results in increased expression of CXXC1 mRNA

NCBI chr18:70,088,407...70,093,786
Ensembl chr18:70,088,460...70,093,778

G

cytochrome b5 type A

decreases expression

EXP

Zinc results in decreased expression of CYB5A mRNA

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome b5 reductase 3

affects expression

ISO

Zinc affects the expression of CYB5R3 mRNA

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome b-245 beta chain

increases expression

EXP

Zinc deficiency results in increased expression of CYBB

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

CYLD lysine 63 deubiquitinase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP1A2 protein]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

ISO

Zinc deficiency results in increased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 26, subfamily a, polypeptide 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP26A1 mRNA

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

EXP

Zinc deficiency results in decreased expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression

EXP

Zinc deficiency results in decreased expression of and results in decreased activity of CYP2C11 protein
Zinc deficiency results in decreased expression of CYP2C11 mRNA

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily c, polypeptide 12

increases expression

EXP

Zinc deficiency results in increased expression of CYP2C12 mRNA

NCBI chr 1:248,619,887...248,681,945
Ensembl chr 1:248,619,882...248,677,042

G

cytochrome P450, family 2, subfamily c, polypeptide 23

multiple interactions
decreases expression

EXP

[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2C23 mRNA]
Zinc deficiency results in decreased expression of CYP2C23 mRNA

PMID:12672911 PMID:15671213 PMID:27919644

NCBI chr 1:252,838,427...252,863,081
Ensembl chr 1:252,838,433...252,863,067

G

cytochrome P450, family 2, subfamily c, polypeptide 24

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2C55 mRNA

NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases expression

ISO

Zinc deficiency results in increased expression of CYP2D6 mRNA

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases expression

EXP
ISO

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]
Zinc deficiency results in increased expression of CYP2E1 protein
[Zinc deficiency co-treated with Ethanol] results in increased expression of CYP2E1 protein

PMID:21424224 PMID:24155903 PMID:27919644

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

increases expression

ISO

Zinc deficiency results in increased expression of CYP2F1 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 2, subfamily r, polypeptide 1

decreases expression

ISO

Zinc deficiency results in decreased expression of CYP2R1 mRNA

NCBI chr 1:178,166,984...178,232,191
Ensembl chr 1:178,219,704...178,232,423

G

cytochrome P450, family 3, subfamily a, polypeptide 18

decreases expression

EXP

Zinc deficiency results in decreased expression of CYP3A18 mRNA

NCBI chr12:13,994,312...14,044,185
Ensembl chr12:13,994,311...14,045,788

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of CYP3A2 mRNA
[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]

PMID:11705462 PMID:27919644

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of CYP3A5 mRNA
Zinc deficiency results in increased expression of CYP3A9 mRNA

PMID:11705462 PMID:18593933

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 2

decreases expression

EXP

Zinc deficiency results in decreased expression of CYP4A2 mRNA

PMID:12672911 PMID:15671213

NCBI chr 5:134,160,356...134,170,908
Ensembl chr 5:134,160,358...134,176,156

G

cytochrome P450, family 4, subfamily b, polypeptide 1

decreases expression
increases expression

EXP

Zinc deficiency results in decreased expression of CYP4B1 mRNA
Zinc deficiency results in increased expression of CYP4B1 mRNA; Zinc results in increased expression of CYP4B1 mRNA

PMID:11717422 PMID:12672911 PMID:17074742

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

EXP

Zinc deficiency results in decreased expression of CYP4F1 mRNA

NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612

G

cytochrome P450, family 4, subfamily f, polypeptide 4

decreases expression

EXP

Zinc deficiency results in decreased expression of CYP4F4 mRNA

NCBI chr 7:12,367,711...12,384,010
Ensembl chr 7:12,367,660...12,384,010

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
decreases activity
increases expression

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CYP7A1 mRNA
Zinc results in decreased activity of CYP7A1 protein
Zinc deficiency results in increased expression of CYP7A1 mRNA

PMID:1175606 PMID:16979875 PMID:18356318

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

CYFIP related Rac1 interactor A

increases expression

ISO

Zinc deficiency results in increased expression of CYRIA mRNA

NCBI chr 6:40,774,165...40,883,005
Ensembl chr 6:40,774,171...40,881,860

G

cystin 1

decreases expression

ISO

Zinc deficiency results in decreased expression of CYS1 mRNA

NCBI chr 6:47,029,440...47,046,671
Ensembl chr 6:47,028,461...47,046,671

G

cytohesin 1

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of CYTH1 mRNA
Zinc deficiency results in increased expression of CYTH1 mRNA

PMID:18593933 PMID:19111725

NCBI chr10:103,901,376...103,984,496
Ensembl chr10:103,864,804...103,984,383

G

cytohesin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of CYTH2 mRNA

NCBI chr 1:105,419,631...105,427,542
Ensembl chr 1:105,419,631...105,427,542

G

defender against cell death 1

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DAD1 mRNA

NCBI chr15:31,647,326...31,667,159
Ensembl chr15:31,647,326...31,667,287

G

diacylglycerol lipase, beta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DAGLB mRNA

NCBI chr12:16,173,345...16,215,777
Ensembl chr12:16,173,345...16,215,758

G

dihydrolipoamide branched chain transacylase E2

increases expression

ISO

Zinc deficiency results in increased expression of DBT mRNA

NCBI chr 2:207,166,660...207,195,528
Ensembl chr 2:207,166,652...207,195,525

G

discoidin, CUB and LCCL domain containing 2

increases expression

ISO

Zinc results in increased expression of DCBLD2 mRNA

NCBI chr11:55,594,691...55,649,113
Ensembl chr11:55,594,691...55,649,085

G

deoxycytidine kinase

decreases expression

ISO

Zinc deficiency results in decreased expression of DCK mRNA

NCBI chr14:19,589,298...19,610,326
Ensembl chr14:19,589,298...19,610,326

G

doublecortin-like kinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DCLK1 mRNA

NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090

G

decapping mRNA 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DCP2 mRNA

NCBI chr18:37,001,615...37,037,949
Ensembl chr18:37,001,615...37,049,939

G

dynactin subunit 1

increases expression

ISO

Zinc deficiency results in increased expression of DCTN1 mRNA

NCBI chr 4:117,228,722...117,261,528
Ensembl chr 4:117,219,349...117,261,528

G

defective in cullin neddylation 1 domain containing 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DCUN1D4 mRNA

NCBI chr14:35,006,792...35,087,285
Ensembl chr14:35,006,792...35,088,520

G

damage specific DNA binding protein 2

increases expression

ISO

Zinc deficiency results in increased expression of DDB2 mRNA

NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066

G

DNA-damage inducible transcript 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression

EXP

Zinc deficiency results in increased expression of DDIT4 mRNA; Zinc results in increased expression of DDIT4 mRNA

PMID:17074742 PMID:19111725

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

discoidin domain receptor tyrosine kinase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DDR2 mRNA

NCBI chr13:84,726,412...84,851,032
Ensembl chr13:84,731,180...84,850,288

G

DEAD-box helicase 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DDX10 mRNA

NCBI chr 8:62,384,876...62,539,585
Ensembl chr 8:62,384,876...62,539,585

G

DEAD-box helicase 17

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of DDX17 mRNA

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747

G

DEAD box helicase 3, Y-linked

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DDX3Y mRNA

NCBI chr Y:1,190,042...1,210,699
Ensembl chr Y:1,191,242...1,210,650

G

DEAD-box helicase 6

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DDX6 mRNA

NCBI chr 8:53,827,661...53,864,538
Ensembl chr 8:53,827,835...53,860,977

G

death effector domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DEDD2 mRNA

NCBI chr 1:89,916,906...89,934,663
Ensembl chr 1:89,919,524...89,936,804

G

DENN domain containing 2B

increases expression

ISO

Zinc results in increased expression of DENND2B mRNA

NCBI chr 1:172,978,895...173,129,623
Ensembl chr 1:172,978,895...173,129,810

G

DENN domain containing 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DENND3 mRNA

NCBI chr 7:107,304,860...107,362,573
Ensembl chr 7:107,220,192...107,362,573

G

DENN domain containing 5A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DENND5A mRNA

NCBI chr 1:173,362,959...173,428,973
Ensembl chr 1:173,362,959...173,428,926

G

DENN domain containing 5B

increases expression

ISO

Zinc deficiency results in increased expression of DENND5B mRNA

NCBI chr 4:183,688,039...183,821,012
Ensembl chr 4:183,692,227...183,820,508

G

DEPP autophagy regulator 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of DEPP1 mRNA

NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233

G

DEP domain containing MTOR-interacting protein

decreases expression

ISO

Zinc deficiency results in decreased expression of DEPTOR mRNA

NCBI chr 7:88,404,745...88,574,065
Ensembl chr 7:88,404,620...88,574,041

G

diacylglycerol O-acyltransferase 1

affects expression
increases expression

EXP

Zinc affects the expression of DGAT1 mRNA
Zinc results in increased expression of DGAT1 mRNA

PMID:17074742 PMID:17181878

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

dihydrodiol dehydrogenase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DHDH mRNA

NCBI chr 1:105,088,108...105,102,560
Ensembl chr 1:105,090,309...105,101,567

G

dehydrogenase/reductase 2

increases expression

ISO

Zinc results in increased expression of DHRS2 mRNA

NCBI chr15:32,658,855...32,673,591
Ensembl chr15:32,659,223...32,673,588

G

diaphanous-related formin 1

increases expression

ISO

Zinc deficiency results in increased expression of DIAPH1 mRNA

NCBI chr18:29,920,889...30,020,280
Ensembl chr18:29,920,889...30,020,280

G

iodothyronine deiodinase 1

increases expression

EXP

Zinc deficiency results in increased expression of DIO1 mRNA

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

dispatched RND transporter family member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DISP1 mRNA

NCBI chr13:97,252,574...97,398,329
Ensembl chr13:97,252,574...97,398,460

G

dickkopf WNT signaling pathway inhibitor 2

decreases expression

ISO

Zinc deficiency results in decreased expression of DKK2 mRNA

NCBI chr 2:223,242,375...223,334,249
Ensembl chr 2:223,242,377...223,334,724

G

dihydrolipoamide dehydrogenase

increases expression

ISO

Zinc deficiency results in increased expression of DLD protein

NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354

G

DLG associated protein 5

increases expression

ISO

Zinc deficiency results in increased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

delta like canonical Notch ligand 4

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in decreased expression of DLL4 mRNA

NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763

G

distal-less homeobox 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DLX2 mRNA

NCBI chr 3:76,777,912...76,781,255
Ensembl chr 3:76,777,912...76,781,255

G

distal-less homeobox 5

decreases expression

EXP

Zinc deficiency results in decreased expression of DLX5 mRNA

NCBI chr 4:35,965,579...35,969,973
Ensembl chr 4:35,965,579...35,969,845

G

deleted in malignant brain tumors 1

increases expression

ISO

Zinc deficiency results in increased expression of DMBT1 mRNA

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:195,047,713...195,126,704

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJA1 mRNA

NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160

G

DnaJ heat shock protein family (Hsp40) member A4

decreases expression

ISO

Zinc deficiency results in decreased expression of DNAJA4 mRNA

NCBI chr 8:63,975,177...63,998,836
Ensembl chr 8:63,981,559...63,998,836

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB2 mRNA

NCBI chr 9:84,179,702...84,187,942
Ensembl chr 9:84,179,695...84,187,942

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

DnaJ heat shock protein family (Hsp40) member B9

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

DnaJ heat shock protein family (Hsp40) member C25

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DNAJC25 mRNA

NCBI chr 5:78,620,608...78,642,921
Ensembl chr 5:78,620,581...78,642,920

G

DNA methyltransferase 3 alpha

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of DNMT3A mRNA; Zinc deficiency results in increased expression of DNMT3A protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of DNMT3A mRNA]

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

dipeptidylpeptidase 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DPP8 mRNA

NCBI chr 8:74,445,815...74,501,017
Ensembl chr 8:74,445,835...74,501,017

G

dopamine receptor D2

multiple interactions
decreases expression

ISO
EXP

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DRD2 mRNA
Zinc deficiency results in decreased expression of DRD2 mRNA

PMID:12517797 PMID:15173390

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dopamine receptor D3

multiple interactions

EXP

Zinc inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

dopamine receptor D4

multiple interactions

EXP

Zinc inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458

G

dystrophin related protein 2

decreases expression

ISO

Zinc deficiency results in decreased expression of DRP2 mRNA

NCBI chr X:101,900,743...101,951,403
Ensembl chr X:101,901,011...101,951,403

G

desmoplakin

affects binding

ISO

DSP protein binds to Zinc

NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121

G

dentin sialophosphoprotein

multiple interactions
decreases expression

ISO

Zinc inhibits the reaction [NFIC protein binds to DSPP promoter]
Zinc results in decreased expression of DSPP mRNA; Zinc results in decreased expression of DSPP protein

NCBI chr14:5,870,232...5,876,339
Ensembl chr14:5,870,232...5,876,339

G

dual specificity phosphatase 1

multiple interactions

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of DUSP1 mRNA
[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of DUSP1 mRNA]; [Taurine binds to Zinc] which results in increased expression of DUSP1 mRNA; [Taurine binds to Zinc] which results in increased expression of DUSP1 protein

PMID:18593933 PMID:26335259

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

dual specificity phosphatase 16

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DUSP16 mRNA

NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:169,278,118...169,361,508

G

dual specificity phosphatase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DUSP2 mRNA

NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:135,009,590...135,011,809

G

dual specificity phosphatase 5

decreases expression
increases expression
multiple interactions

EXP
ISO

Zinc results in decreased expression of DUSP5 mRNA
Zinc deficiency results in increased expression of DUSP5 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of DUSP5 mRNA

PMID:17074742 PMID:18593933 PMID:22171008

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dual specificity phosphatase 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:206,598,942...206,612,441

G

dynein cytoplasmic 1 heavy chain 1

decreases expression

ISO

Zinc results in decreased expression of DYNC1H1 mRNA

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116

G

E2F transcription factor 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of E2F6 mRNA

NCBI chr 6:45,320,993...45,337,437
Ensembl chr 6:45,320,996...45,337,428

G

E2F transcription factor 8

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

enoyl-CoA hydratase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of ECH1 mRNA

PMID:12672911 PMID:15671213

NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440

G

enoyl-CoA delta isomerase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of ECI1 mRNA

PMID:12672911 PMID:15671213

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

ectodysplasin-A

decreases expression

ISO

Zinc deficiency results in decreased expression of EDA mRNA

NCBI chr X:69,118,577...69,520,274
Ensembl chr X:69,118,796...69,520,274

G

endothelin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type B

decreases expression

EXP

Zinc results in decreased expression of EDNRB mRNA

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

eukaryotic translation elongation factor 1 alpha 1

affects binding

ISO

EEF1A1 protein binds to Zinc

NCBI chr 8:88,221,839...88,225,688
Ensembl chr 8:88,221,843...88,225,072

G

eukaryotic elongation factor-2 kinase

increases expression

EXP

Zinc results in increased expression of EEF2K mRNA

NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:184,824,420...184,888,048

G

EF-hand calcium binding domain 7

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EFCAB7 mRNA

NCBI chr 5:119,640,841...119,691,566
Ensembl chr 5:119,640,761...119,691,563

G

ephrin A4

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EFNA4 mRNA

NCBI chr 2:177,046,463...177,050,713
Ensembl chr 2:177,046,463...177,050,713

G

ephrin B2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EFNB2 mRNA

NCBI chr16:87,485,215...87,529,224
Ensembl chr16:87,485,198...87,529,208

G

epidermal growth factor

increases uptake
increases import
increases expression
multiple interactions

ISO
EXP

EGF protein results in increased uptake of Zinc
EGF protein results in increased import of Zinc
Zinc deficiency results in increased expression of EGF mRNA
Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc]
Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]

PMID:1502195 PMID:12947092 PMID:16443356 PMID:19111725

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation
decreases expression

ISO
EXP

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; AG 1879 inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; HBEGF protein affects the reaction [Zinc results in increased phosphorylation of EGFR protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; Zinc results in increased phosphorylation of and results in increased activity of EGFR protein
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Zinc results in increased phosphorylation of EGFR protein]; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA; Zinc promotes the reaction [EGFR protein binds to SRC protein]
Zinc deficiency results in decreased expression of EGFR mRNA

PMID:11983694 PMID:12672911 PMID:12915106 PMID:12972402 PMID:15980035 More...

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

egl-9 family hypoxia-inducible factor 1

multiple interactions
decreases expression

ISO

Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]
Zinc results in decreased expression of EGLN1 mRNA

PMID:16579968 PMID:18316168

NCBI chr19:69,765,276...69,804,681

G

egl-9 family hypoxia-inducible factor 3

affects expression

EXP

Zinc affects the expression of EGLN3 mRNA

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015

G

early growth response 1

decreases expression
increases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of EGR1 protein
Zinc results in increased expression of EGR1 mRNA; Zinc results in increased expression of EGR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of EGR1 protein]; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGR1 mRNA; Dizocilpine Maleate inhibits the reaction [Zinc results in increased expression of EGR1 protein]; Nimodipine inhibits the reaction [Zinc results in increased expression of EGR1 protein]
[PCI 5002 co-treated with Zinc] results in increased expression of EGR1 mRNA

PMID:10428039 PMID:12107072 PMID:18593933 PMID:33549593

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

early growth response 4

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EGR4 mRNA

NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368

G

EH domain binding protein 1-like 1

increases expression

ISO

Zinc deficiency results in increased expression of EHBP1L1 mRNA

NCBI chr 1:212,423,444...212,444,357
Ensembl chr 1:212,423,447...212,443,598

G

EH-domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EHD1 mRNA

NCBI chr 1:213,009,113...213,031,488
Ensembl chr 1:213,008,049...213,031,485

G

EH-domain containing 3

decreases expression

ISO

Zinc deficiency results in decreased expression of EHD3 mRNA

NCBI chr 6:27,392,709...27,417,445
Ensembl chr 6:27,392,709...27,417,445

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

EXP

Zinc deficiency results in decreased expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EIF1 mRNA

NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654

G

eukaryotic translation initiation factor 1A domain containing

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EIF1AD mRNA

NCBI chr 1:212,103,715...212,109,015
Ensembl chr 1:212,103,892...212,109,017

G

eukaryotic translation initiation factor 2 alpha kinase 1

decreases activity

ISO

Zinc results in decreased activity of EIF2AK1 protein

NCBI chr12:15,824,431...15,858,266
Ensembl chr12:15,825,124...15,858,281

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EIF2AK3 mRNA

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 3, subunit C

increases expression

EXP

Zinc deficiency results in increased expression of EIF3C mRNA

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 4 gamma, 3

increases expression

ISO

Zinc deficiency results in increased expression of EIF4G3 mRNA

NCBI chr 5:155,481,378...155,702,194
Ensembl chr 5:155,481,378...155,702,194

G

eukaryotic translation initiation factor 4H

increases expression

EXP

Zinc deficiency results in increased expression of EIF4H mRNA

NCBI chr12:27,719,527...27,736,350
Ensembl chr12:27,719,321...27,736,346

G

eukaryotic translation initiation factor 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EIF5 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of EIF5 mRNA

PMID:16979875 PMID:18593933

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821

G

eukaryotic translation initiation factor 5A

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of EIF5A mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of EIF5A mRNA]

NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330

G

E74 like ETS transcription factor 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ELF3 mRNA

NCBI chr13:49,242,265...49,247,102
Ensembl chr13:49,242,267...49,247,380

G

E74 like ETS transcription factor 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ELF4 mRNA

NCBI chr X:132,465,290...132,508,175
Ensembl chr X:132,468,539...132,478,689

G

ETS transcription factor ELK1

multiple interactions

EXP

Zinc results in increased phosphorylation of and results in increased activity of ELK1 protein

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

elongation factor for RNA polymerase II 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ELL2 mRNA

NCBI chr 2:6,910,446...6,990,654
Ensembl chr 2:6,921,771...7,016,199

G

elastin

increases expression

ISO

Zinc deficiency results in increased expression of ELN mRNA

NCBI chr12:27,604,983...27,648,413
Ensembl chr12:27,604,680...27,648,413

G

elongin A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ELOA mRNA

NCBI chr 5:153,513,246...153,530,819
Ensembl chr 5:153,515,066...153,530,916

G

EMI domain containing 1

increases expression

ISO

Zinc results in increased expression of EMID1 mRNA

NCBI chr14:84,214,530...84,257,628
Ensembl chr14:84,214,530...84,257,579

G

epithelial membrane protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EMP1 mRNA

NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:169,931,440...169,964,365

G

empty spiracles homeobox 1

multiple interactions

EXP

Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of EMX1 protein]

NCBI chr 4:119,282,692...119,300,822
Ensembl chr 4:119,282,692...119,300,817

G

endo-beta-N-acetylglucosaminidase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ENGASE mRNA

NCBI chr10:104,205,753...104,218,416
Ensembl chr10:104,205,752...104,218,411

G

enolase 1

affects binding
increases expression
multiple interactions

ISO
EXP

ENO1 protein binds to Zinc
Zinc deficiency results in increased expression of ENO1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of ENO1 mRNA]

PMID:14534351 PMID:16140947

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

enolase 3

decreases expression

EXP

Zinc deficiency results in decreased expression of ENO3 mRNA

NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,866,101...55,874,540

G

ectonucleotide pyrophosphatase/phosphodiesterase 4

decreases expression

ISO

Zinc deficiency results in decreased expression of ENPP4 mRNA

NCBI chr 9:24,386,351...24,396,248
Ensembl chr 9:24,360,272...24,396,152

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

decreases activity
multiple interactions

ISO

Zinc results in decreased activity of ENPP7 protein
Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein]

NCBI chr10:104,740,763...104,745,760
Ensembl chr10:104,740,763...104,745,760

G

eomesodermin

multiple interactions

EXP

Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of EOMES protein]

NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:127,059,215...127,067,070

G

E1A binding protein p300

affects expression
multiple interactions

ISO

Zinc affects the expression of EP300 protein
[Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA; chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]]; EP300 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]; EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]; Zinc promotes the reaction [MTF1 protein binds to EP300 protein binds to CREBBP protein]; Zinc promotes the reaction [MTF1 protein binds to EP300 protein]; Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]]

PMID:16636310 PMID:18458062 PMID:18605988 PMID:21035574 PMID:21467744

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

ectopic P-granules 5 autophagy tethering factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EPG5 mRNA

NCBI chr18:73,679,106...73,776,694
Ensembl chr18:73,679,116...73,776,677

G

Eph receptor A2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:158,888,629...158,917,234

G

epoxide hydrolase 1

increases expression

EXP

Zinc results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

ISO

Zinc results in increased expression of ERCC1 mRNA

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:88,118,891...88,139,120

G

glutamate-rich 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ERICH1 mRNA

NCBI chr16:82,203,536...82,271,361
Ensembl chr16:82,203,610...82,272,989

G

endoplasmic reticulum protein 27

decreases expression

ISO

Zinc deficiency results in decreased expression of ERP27 mRNA

NCBI chr 4:171,535,845...171,552,848
Ensembl chr 4:171,535,847...171,553,072

G

establishment of sister chromatid cohesion N-acetyltransferase 2

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA

NCBI chr15:44,210,124...44,230,785
Ensembl chr15:44,210,641...44,231,304
Ensembl chr15:44,210,641...44,231,304

G

estrogen receptor 1

affects binding
increases expression
multiple interactions

ISO

Zinc binds to ESR1 protein
Zinc deficiency results in increased expression of ESR1 protein
Zinc inhibits the reaction [Cobalt binds to ESR1 protein]

PMID:14640689 PMID:25088245

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

extended synaptotagmin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ESYT2 mRNA

NCBI chr 6:143,359,870...143,455,600
Ensembl chr 6:143,362,694...143,455,593

G

eukaryotic translation termination factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ETF1 mRNA

NCBI chr18:26,776,518...26,804,857
Ensembl chr18:26,777,858...26,804,613

G

ethanolamine kinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ETNK1 mRNA

NCBI chr 4:177,857,001...177,901,278
Ensembl chr 4:177,856,960...177,924,721

G

ETS proto-oncogene 1, transcription factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

ETS proto-oncogene 2, transcription factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ETS2 mRNA

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:48,491,394...48,507,842

G

ETS variant transcription factor 4

increases activity

ISO

Zinc deficiency results in increased activity of ETV4 protein

NCBI chr10:87,206,977...87,222,202
Ensembl chr10:87,206,977...87,222,318

G

exosome component 1

decreases expression

ISO

Zinc deficiency results in decreased expression of EXOSC1 mRNA

NCBI chr 1:250,684,746...250,694,748
Ensembl chr 1:250,684,750...250,694,748

G

exostosin glycosyltransferase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of EXT1 mRNA

NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567

G

EYA transcriptional coactivator and phosphatase 3

increases expression

ISO

Zinc deficiency results in increased expression of EYA3 mRNA

NCBI chr 5:150,090,535...150,218,855
Ensembl chr 5:150,137,256...150,218,852

G

coagulation factor XII

affects binding

ISO

F12 protein binds to Zinc

NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664

G

coagulation factor XIII B chain

affects binding

ISO

F13B protein binds to Zinc

NCBI chr13:53,681,639...53,707,114
Ensembl chr13:53,681,622...53,707,300

G

coagulation factor II, thrombin

affects binding

ISO

F2 protein binds to Zinc

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

ISO

Zinc results in decreased expression of F2RL2 mRNA

NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:28,706,501...28,712,473

G

coagulation factor V

increases expression

ISO

Zinc deficiency results in increased expression of F5 mRNA

PMID:20857495 PMID:22171008

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247

G

fatty acid binding protein 1

decreases expression
affects expression
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of FABP1 protein
Zinc deficiency affects the expression of FABP1 mRNA
[Zinc deficiency co-treated with Ethanol] affects the expression of FABP1 mRNA

PMID:15671213 PMID:24155903

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

fatty acid binding protein 2

increases expression

EXP

Zinc deficiency results in increased expression of FABP2 mRNA

NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686

G

fatty acid binding protein 4

multiple interactions
increases expression
decreases expression

ISO
EXP

IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of FABP4 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of FABP4 mRNA]
Zinc deficiency results in increased expression of FABP4 mRNA

PMID:11717422 PMID:18316168

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fatty acid binding protein 5

decreases expression
multiple interactions

ISO

Zinc results in decreased expression of FABP5 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of FABP5 mRNA

PMID:15226459 PMID:33549593

NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127

G

fatty acid binding protein 7

increases expression

EXP

Zinc deficiency results in increased expression of FABP7 mRNA

PMID:12672911 PMID:15671213

NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,669,601...37,675,907

G

fatty acid desaturase 1

decreases expression

ISO

Zinc results in decreased expression of FADS1 mRNA

NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615

G

family with sequence similarity 117, member A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FAM117A mRNA

NCBI chr10:80,778,229...80,822,119
Ensembl chr10:80,755,883...80,822,119

G

family with sequence similarity 120 member C

increases expression

ISO

Zinc deficiency results in increased expression of FAM120C mRNA

NCBI chr X:23,765,089...23,922,059
Ensembl chr X:23,766,976...23,920,840

G

family with sequence similarity 131, member A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FAM131A mRNA

NCBI chr11:93,715,979...93,725,930
Ensembl chr11:93,716,002...93,725,919

G

family with sequence similarity 162, member A

increases expression

ISO

Zinc deficiency results in increased expression of FAM162A mRNA

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

family with sequence similarity 204, member A

decreases expression

ISO

Zinc deficiency results in decreased expression of FAM204A mRNA

NCBI chr 1:269,323,473...269,352,772
Ensembl chr 1:269,323,473...269,352,772

G

family with sequence similarity 220, member A

decreases expression

ISO

Zinc deficiency results in decreased expression of FAM220A mRNA

NCBI chr12:16,111,593...16,127,584
Ensembl chr12:16,109,425...16,133,421

G

family with sequence similarity 43, member A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FAM43A mRNA

NCBI chr11:83,633,165...83,636,313
Ensembl chr11:83,633,154...83,695,297

G

family with sequence similarity 53, member C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FAM53C mRNA

NCBI chr18:26,638,781...26,652,294
Ensembl chr18:26,638,062...26,652,290

G

family with sequence similarity 83, member D

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FAM83D mRNA

NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:167,841,791...167,861,061

G

Fas cell surface death receptor

increases expression
decreases expression
multiple interactions

ISO

Zinc results in increased expression of FAS protein
Zinc deficiency results in increased expression of FAS protein
Zinc deficiency results in decreased expression of FAS mRNA
[Zinc deficiency co-treated with Ethanol] results in decreased expression of FAS mRNA; [Zinc deficiency co-treated with Ethanol] results in increased expression of FAS protein

PMID:16472982 PMID:24155903

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression
decreases expression
multiple interactions

ISO

Zinc results in increased expression of FASLG protein
Zinc deficiency results in decreased expression of FASLG mRNA
Zinc results in increased expression of FASLG mRNA; Zinc results in increased expression of FASLG protein
Acetylcysteine inhibits the reaction [Zinc results in increased expression of FASLG protein]

PMID:11864783 PMID:16472982 PMID:22171008

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

affects activity

EXP

Zinc affects the activity of FASN protein

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

FAU ubiquitin like and ribosomal protein S30 fusion

decreases expression

ISO

Zinc deficiency results in decreased expression of FAU mRNA

NCBI chr 1:212,779,429...212,781,028
Ensembl chr 1:212,779,473...212,781,026
Ensembl chr 1:212,779,473...212,781,026

G

F-box DNA helicase 1

increases expression

ISO

Zinc deficiency results in increased expression of FBH1 mRNA

NCBI chr17:71,659,351...71,697,431
Ensembl chr17:71,659,249...71,697,432

G

F-box and leucine-rich repeat protein 12

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXL12 mRNA

NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:27,445,823...27,457,772

G

F-box and leucine-rich repeat protein 14

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXL14 mRNA

NCBI chr 4:154,334,820...154,338,638
Ensembl chr 4:154,334,092...154,377,959

G

F-box protein 11

increases expression

ISO

Zinc deficiency results in increased expression of FBXO11 mRNA

NCBI chr 6:12,240,348...12,316,223
Ensembl chr 6:12,239,801...12,316,221

G

F-box protein 28

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXO28 mRNA

NCBI chr13:96,527,667...96,553,138
Ensembl chr13:96,527,670...96,553,138

G

F-box protein 3

decreases expression

ISO

Zinc deficiency results in decreased expression of FBXO3 mRNA

NCBI chr 3:110,872,185...110,904,479
Ensembl chr 3:110,872,220...110,904,479

G

F-box protein 30

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXO30 mRNA

NCBI chr 1:7,475,636...7,491,719
Ensembl chr 1:7,475,575...7,493,199

G

F-box protein 32

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXO32 mRNA

NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491

G

F-box protein 33

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXO33 mRNA

NCBI chr 6:82,635,509...82,669,441
Ensembl chr 6:82,635,521...82,667,440

G

F-box and WD repeat domain containing 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXW10 mRNA

NCBI chr10:48,012,555...48,051,136
Ensembl chr10:47,958,677...48,051,136

G

F-box and WD repeat domain containing 7

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FBXW7 mRNA

NCBI chr 2:172,447,738...172,609,591
Ensembl chr 2:172,447,738...172,609,591

G

Fc epsilon receptor Ia

multiple interactions

ISO

Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]; Zinc promotes the reaction [FCER1A protein affects the localization of PRKCB protein]; Zinc promotes the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Zinc promotes the reaction [FCER1A protein results in increased expression of IL6 protein]; Zinc promotes the reaction [FCER1A protein results in increased expression of TNF mRNA]; Zinc promotes the reaction [FCER1A protein results in increased expression of TNF protein]

NCBI chr13:88,218,427...88,224,723
Ensembl chr13:88,218,420...88,224,681

G

fem-1 homolog C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FEM1C mRNA

NCBI chr18:41,419,511...41,445,300
Ensembl chr18:41,419,511...41,445,300

G

flap structure-specific endonuclease 1

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in decreased expression of FEN1 mRNA

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016

G

FERM domain containing kindlin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FERMT2 mRNA

NCBI chr15:21,162,603...21,257,995
Ensembl chr15:21,162,605...21,258,115

G

fetuin B

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of FETUB mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of FETUB mRNA]

PMID:16140947 PMID:19111725

NCBI chr11:91,586,750...91,599,789
Ensembl chr11:91,586,748...91,599,310

G

fibrinogen alpha chain

affects binding

ISO

FGA protein binds to Zinc

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577

G

fibroblast growth factor 1

increases expression

EXP

Zinc results in increased expression of FGF1 mRNA

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393

G

fibroblast growth factor 16

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FGF16 mRNA

NCBI chr X:74,882,863...74,893,598
Ensembl chr X:74,882,995...74,944,246

G

fibroblast growth factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibroblast growth factor 9

multiple interactions

EXP

[Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 protein

NCBI chr15:36,325,552...36,369,995
Ensembl chr15:36,325,599...36,367,926

G

four and a half LIM domains 5

decreases expression

ISO

Zinc deficiency results in decreased expression of FHL5 mRNA

NCBI chr 5:43,704,493...43,753,356
Ensembl chr 5:43,704,498...43,753,102

G

FKBP prolyl isomerase 11

increases expression

ISO

Zinc deficiency results in increased expression of FKBP11 mRNA

NCBI chr 7:131,750,828...131,757,784
Ensembl chr 7:131,750,672...131,770,123

G

FKBP prolyl isomerase 3

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of FKBP3 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of FKBP3 mRNA]

NCBI chr 6:88,850,137...88,862,542
Ensembl chr 6:88,843,879...88,863,447

G

FKBP prolyl isomerase 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FKBP4 mRNA

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:163,389,464...163,397,918

G

folliculin

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA

NCBI chr10:45,088,164...45,107,581
Ensembl chr10:45,088,167...45,107,309

G

flotillin 2

increases expression

ISO

Zinc deficiency results in increased expression of FLOT2 mRNA

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:63,423,806...63,445,810

G

Fms related receptor tyrosine kinase 1

decreases expression
increases expression

ISO
EXP

Zinc deficiency results in decreased expression of FLT1 mRNA
Zinc results in increased expression of FLT1 mRNA

PMID:17074742 PMID:18356318

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

flavin containing dimethylaniline monoxygenase 2

decreases expression

ISO

Zinc deficiency results in decreased expression of FMO2 mRNA

NCBI chr13:77,755,131...77,777,597
Ensembl chr13:77,757,629...77,777,534

G

flavin containing dimethylaniline monoxygenase 4

decreases expression

ISO

Zinc deficiency results in decreased expression of FMO4 mRNA

NCBI chr13:77,687,909...77,706,100
Ensembl chr13:77,687,909...77,706,100

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

fibronectin 1

multiple interactions
affects binding

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FN1 mRNA
Zinc inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
FN1 protein binds to Zinc

PMID:16979875 PMID:23896426 PMID:31009641

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

folliculin interacting protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FNIP1 mRNA

NCBI chr10:39,068,432...39,151,552
Ensembl chr10:39,068,445...39,151,552

G

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

EXP

Zinc binds to and results in increased activity of [FNTA protein binds to FNTB protein]

NCBI chr16:72,767,864...72,786,193
Ensembl chr16:72,767,627...72,788,229

G

farnesyltransferase, CAAX box, subunit beta

multiple interactions

EXP

Zinc binds to and results in increased activity of [FNTA protein binds to FNTB protein]

NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression
increases stability
multiple interactions
increases phosphorylation

ISO
EXP

Zinc results in increased expression of FOS protein
Zinc deficiency results in decreased expression of FOS mRNA
Zinc results in increased stability of FOS mRNA
Zinc results in increased expression of FOS mRNA; Zinc results in increased expression of FOS protein
[PCI 5002 co-treated with Zinc] results in increased expression of FOS mRNA
Zinc results in increased phosphorylation of FOS protein

PMID:7860645 PMID:16373669 PMID:16472982 PMID:18593933 PMID:21893222

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FOSB mRNA

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

FOS like 1, AP-1 transcription factor subunit

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of FOSL1 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of FOSL1 mRNA

PMID:18593933 PMID:19111725

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FOSL2 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FOSL2 mRNA
Zinc deficiency results in decreased expression of FOSL2 mRNA

PMID:16979875 PMID:18356318 PMID:18593933

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box A1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of FOXA1 mRNA

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191

G

forkhead box A2

increases degradation

ISO

Zinc deficiency results in increased degradation of FOXA2 protein

NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:155,923,307...155,928,757

G

forkhead box B1

increases expression

ISO

Zinc deficiency results in increased expression of FOXB1 mRNA

NCBI chr 8:79,288,161...79,290,781
Ensembl chr 8:79,287,616...79,291,490

G

forkhead box D1

increases expression

ISO

Zinc results in increased expression of FOXD1 mRNA

NCBI chr 2:31,436,802...31,439,222
Ensembl chr 2:31,436,813...31,439,399

G

forkhead box F2

decreases expression

ISO

Zinc results in decreased expression of FOXF2 mRNA

NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,846,603...33,051,259

G

forkhead box H1

increases activity

ISO

Zinc deficiency results in increased activity of FOXH1 protein

NCBI chr 7:110,268,608...110,272,105
Ensembl chr 7:110,268,612...110,270,692

G

forkhead box N2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FOXN2 mRNA

NCBI chr 6:11,772,180...11,818,751
Ensembl chr 6:11,772,180...11,818,751

G

forkhead box O1

multiple interactions
affects localization
increases phosphorylation

ISO
EXP

wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]
Zinc inhibits the reaction [FOXO1 protein results in increased expression of CAT protein]

PMID:16973122 PMID:22427991

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O4

multiple interactions
increases phosphorylation

ISO

wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO4 protein]

NCBI chr X:70,425,218...70,432,120
Ensembl chr X:70,425,563...70,432,120

G

FRAT regulator of WNT signaling pathway 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FRAT2 mRNA

NCBI chr 1:250,603,450...250,605,779
Ensembl chr 1:250,603,088...250,606,921

G

FERM domain containing 4B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FRMD4B mRNA

NCBI chr 4:131,452,361...131,778,734
Ensembl chr 4:131,452,365...131,640,287

G

FERM domain containing 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FRMD8 mRNA

NCBI chr 1:212,572,534...212,593,181
Ensembl chr 1:212,572,537...212,592,695

G

fibroblast growth factor receptor substrate 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FRS2 mRNA

NCBI chr 7:54,597,182...54,678,656
Ensembl chr 7:54,597,182...54,678,774

G

40S small subunit processome assembly factor 1

decreases expression

ISO

Zinc deficiency results in decreased expression of FSAF1 mRNA

NCBI chr19:69,705,313...69,719,894
Ensembl chr19:69,705,321...69,720,093

G

ferritin light chain 1

increases expression

ISO

Zinc deficiency results in increased expression of FTL mRNA; Zinc results in increased expression of FTL mRNA
Zinc deficiency results in increased expression of FTL protein

PMID:12888634 PMID:15984569 PMID:18073202

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

fucosyltransferase 9

decreases expression

ISO

Zinc deficiency results in decreased expression of FUT9 mRNA

NCBI chr 5:44,148,371...44,361,209
Ensembl chr 5:44,146,152...44,362,823

G

FMR1 autosomal homolog 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of FXR1 mRNA

NCBI chr 2:118,812,287...118,865,813
Ensembl chr 2:118,811,980...118,867,027

G

FXYD domain-containing ion transport regulator 2

decreases expression

EXP

Zinc deficiency results in decreased expression of FXYD2 mRNA

NCBI chr 8:54,609,658...54,616,788
Ensembl chr 8:54,609,658...54,616,957

G

FXYD domain-containing ion transport regulator 4

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of FXYD4 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of FXYD4 mRNA]

NCBI chr 4:152,782,181...152,786,118
Ensembl chr 4:152,782,181...152,786,039

G

G0/G1switch 2

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of G0S2 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of G0S2 mRNA]

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

G2/M-phase specific E3 ubiquitin protein ligase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of G2E3 mRNA

NCBI chr 6:74,498,801...74,530,703
Ensembl chr 6:74,503,109...74,528,198

G

glucose-6-phosphate dehydrogenase

affects activity

EXP

Zinc affects the activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GABA type A receptor associated protein like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578

G

GABA type A receptor associated protein like 2

affects expression

ISO

Zinc affects the expression of GABARAPL2 mRNA

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:56,819,791...56,830,660

G

GA binding protein transcription factor subunit alpha

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GABPA mRNA

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

EXP

Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Zinc results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

gamma-aminobutyric acid type A receptor subunit alpha6

increases response to substance

ISO

GABRA6 protein results in increased susceptibility to Zinc

NCBI chr10:27,311,965...27,327,337
Ensembl chr10:27,311,979...27,327,234

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

EXP

Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Zinc results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171

G

gamma-aminobutyric acid type A receptor subunit delta

affects expression

EXP

Zinc affects the expression of GABRD mRNA

NCBI chr 5:171,240,813...171,252,709
Ensembl chr 5:171,240,789...171,253,094

G

gamma-aminobutyric acid type A receptor subunit epsilon

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GABRE mRNA

NCBI chr X:155,102,078...155,120,821
Ensembl chr X:155,102,083...155,120,735

G

gamma-aminobutyric acid type A receptor subunit gamma 2

affects response to substance
multiple interactions

EXP

GABRG2 protein affects the susceptibility to Zinc
Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Zinc results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

PMID:10797553 PMID:17054655

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523

G

gamma-aminobutyric acid type A receptor subunit pi

increases expression

ISO

Zinc deficiency results in increased expression of GABRP mRNA

NCBI chr10:18,647,243...18,673,806
Ensembl chr10:18,647,243...18,673,727

G

gamma-aminobutyric acid type A receptor subunit rho3

multiple interactions

EXP

Zinc inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABRR3 protein]

NCBI chr11:54,372,017...54,424,466
Ensembl chr11:54,372,017...54,424,466

G

glutamate decarboxylase 1

increases expression

ISO

Zinc deficiency results in increased expression of GAD1 mRNA

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

growth arrest and DNA-damage-inducible, alpha

decreases expression
increases expression
multiple interactions

ISO
EXP

Zinc results in decreased expression of GADD45A mRNA
Zinc deficiency results in increased expression of GADD45A mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of GADD45A mRNA]

PMID:15226459 PMID:19111725

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GADD45B mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GADD45B mRNA

PMID:18593933 PMID:33549593

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

growth arrest and DNA-damage-inducible, gamma

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GADD45G mRNA

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369

G

galactose-1-phosphate uridylyltransferase

decreases expression

EXP

Zinc deficiency results in decreased expression of GALT mRNA

NCBI chr 5:61,722,871...61,726,128
Ensembl chr 5:61,722,466...61,726,125

G

growth associated protein 43

multiple interactions

EXP

Zinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

glyceraldehyde-3-phosphate dehydrogenase

affects binding

ISO

GAPDH protein binds to Zinc

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of GART mRNA

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

gastrin

increases expression

ISO

Zinc results in increased expression of GAST mRNA

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880

G

GATA binding protein 2

multiple interactions

ISO

[sodium arsenite binds to GATA2 protein] which results in decreased abundance of Zinc

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

GATA binding protein 4

decreases expression

EXP

Zinc results in decreased expression of GATA4 mRNA

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

GATA binding protein 6

increases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of GATA6 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of GATA6 mRNA

PMID:17074742 PMID:18593933

NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322

G

GATA zinc finger domain containing 2A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GATAD2A mRNA

NCBI chr16:19,463,500...19,553,497
Ensembl chr16:19,463,500...19,553,497

G

grancalcin

increases expression

ISO

Zinc deficiency results in increased expression of GCA mRNA

NCBI chr 3:67,705,874...67,738,475
Ensembl chr 3:67,705,890...67,737,387

G

GRIP and coiled-coil domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GCC1 mRNA

NCBI chr 4:57,996,261...58,008,126
Ensembl chr 4:57,996,267...58,002,185

G

glucagon

decreases secretion
multiple interactions

EXP
ISO

Zinc results in decreased secretion of GCG protein
Zinc inhibits the reaction [Glucose results in increased secretion of GCG protein]; Zinc inhibits the reaction [Pyruvic Acid results in increased secretion of GCG protein]

PMID:15919803 PMID:18250168

NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533

G

GTP cyclohydrolase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GCH1 mRNA

NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412

G

glucokinase

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GCK mRNA

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression

ISO
EXP

acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [Zinc deficiency results in increased cleavage of GCLC protein]; Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein]; Zinc deficiency results in decreased expression of and results in increased cleavage of GCLC protein
Zinc deficiency results in decreased expression of GCLC mRNA
Zinc deficiency results in decreased expression of GCLC mRNA; Zinc deficiency results in decreased expression of GCLC protein

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

decreases expression

ISO
EXP

Zinc deficiency results in decreased expression of GCLM mRNA; Zinc deficiency results in decreased expression of GCLM protein

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glucosaminyl (N-acetyl) transferase 1

increases expression

EXP

Zinc results in increased expression of GCNT1 mRNA

NCBI chr 1:224,145,104...224,182,496
Ensembl chr 1:224,141,108...224,185,741

G

glucosaminyl (N-acetyl) transferase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GCNT2 mRNA

NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989

G

growth differentiation factor 10

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of GDF10 mRNA

NCBI chr16:9,243,434...9,256,788
Ensembl chr16:9,243,317...9,256,794

G

growth differentiation factor 15

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of GDF15 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of GDF15 mRNA]

PMID:18593933 PMID:19111725

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

GTP binding protein overexpressed in skeletal muscle

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GEM mRNA

NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542

G

growth factor independent 1B transcriptional repressor

decreases expression

ISO

Zinc deficiency results in decreased expression of GFI1B mRNA

NCBI chr 3:32,338,213...32,350,963
Ensembl chr 3:32,338,214...32,350,916

G

glutamine fructose-6-phosphate transaminase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GFPT1 mRNA

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:121,054,045...121,103,799

G

glutamine-fructose-6-phosphate transaminase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GFPT2 mRNA

NCBI chr10:34,616,146...34,662,420
Ensembl chr10:34,615,370...34,662,419

G

GDNF family receptor alpha 2

increases expression

ISO

Zinc deficiency results in increased expression of GFRA2 mRNA

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782

G

gamma-glutamyltransferase 1

multiple interactions

EXP

[Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of GGT1 protein

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

growth hormone 1

multiple interactions

ISO
EXP

Zinc promotes the reaction [GH1 protein binds to PRLR protein]
GH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR mRNA]; GH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR protein]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]

PMID:10720163 PMID:10985758 PMID:12915731

NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859

G

growth hormone receptor

multiple interactions
decreases expression

EXP

GH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR mRNA]; GH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR protein]
Zinc deficiency results in decreased expression of GHR mRNA; Zinc deficiency results in decreased expression of GHR protein

PMID:7722689 PMID:10985758

NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331

G

ghrelin and obestatin prepropeptide

increases expression

EXP

Zinc results in increased expression of GHRL mRNA

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

gap junction protein, alpha 1

decreases expression
increases expression

EXP

Zinc results in decreased expression of GJA1 mRNA
Zinc deficiency results in increased expression of GJA1 mRNA; Zinc deficiency results in increased expression of GJA1 protein; Zinc results in increased expression of GJA1 mRNA

PMID:15159208 PMID:17074742 PMID:18224284 PMID:19111725

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glycerol kinase

increases expression

EXP

Zinc deficiency results in increased expression of GK mRNA

PMID:12672911 PMID:15671213

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

glycerol kinase 5

decreases expression

ISO

Zinc deficiency results in decreased expression of GK5 mRNA

NCBI chr 8:105,562,018...105,630,975
Ensembl chr 8:105,562,050...105,631,978

G

glycine decarboxylase

increases expression

ISO

Zinc deficiency results in increased expression of GLDC mRNA

NCBI chr 1:237,296,753...237,375,620
Ensembl chr 1:237,296,753...237,375,604

G

glycine receptor, alpha 1

affects binding
increases activity
decreases activity
affects response to substance
decreases response to substance

ISO
EXP

GLRA1 protein binds to Zinc
Zinc results in increased activity of GLRA1 protein
Zinc results in decreased activity of GLRA1 protein
GLRA1 protein affects the susceptibility to Zinc
GLRA1 protein mutant form results in decreased susceptibility to Zinc

PMID:7752562 PMID:15081878 PMID:16842826 PMID:17114051

NCBI chr10:40,128,284...40,228,612
Ensembl chr10:40,130,121...40,227,815

G

glutamate-ammonia ligase

increases expression

EXP

Zinc results in increased expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

ganglioside GM2 activator

increases expression

ISO

Zinc deficiency results in increased expression of GM2A mRNA

NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451

G

glia maturation factor, beta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GMFB mRNA

NCBI chr15:22,549,705...22,560,125
Ensembl chr15:22,547,034...22,560,308

G

GDP-mannose pyrophosphorylase A

increases expression

ISO

Zinc deficiency results in increased expression of GMPPA mRNA

NCBI chr 9:84,375,373...84,382,917
Ensembl chr 9:84,375,425...84,382,916

G

GDP-mannose pyrophosphorylase B

increases expression

ISO

Zinc deficiency results in increased expression of GMPPB mRNA

NCBI chr 8:117,616,029...117,622,866

G

G protein subunit alpha 14

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GNA14 mRNA

NCBI chr 1:223,141,802...223,324,210
Ensembl chr 1:223,141,802...223,324,210

G

G protein subunit gamma 2

decreases expression

ISO

Zinc deficiency results in decreased expression of GNG2 mRNA

NCBI chr15:4,365,222...4,466,060
Ensembl chr15:4,365,135...4,466,059

G

glyceronephosphate O-acyltransferase

increases expression

EXP

Zinc deficiency results in increased expression of GNPAT mRNA

NCBI chr19:69,719,707...69,746,244
Ensembl chr19:69,719,394...69,746,244

G

N-acetylglucosamine-1-phosphate transferase subunit gamma

increases expression

ISO

Zinc results in increased expression of GNPTG mRNA

NCBI chr10:14,756,685...14,761,636

G

gonadotropin releasing hormone receptor

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of GNRHR mRNA

NCBI chr14:22,211,666...22,229,654

G

golgin A3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GOLGA3 mRNA

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226

G

glutamic-oxaloacetic transaminase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of GOT1 mRNA

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic-oxaloacetic transaminase 2

decreases expression

ISO

Zinc results in decreased expression of GOT2 protein

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111

G

glycerol-3-phosphate acyltransferase, mitochondrial

affects expression
decreases expression
multiple interactions

EXP
ISO

Zinc affects the expression of GPAM mRNA
Zinc deficiency results in decreased expression of GPAM mRNA
[Zinc deficiency co-treated with Ethanol] results in decreased expression of GPAM mRNA

PMID:17181878 PMID:24155903

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

glycerol-3-phosphate acyltransferase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552

G

G patch domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GPATCH2 mRNA

NCBI chr13:101,316,413...101,457,109
Ensembl chr13:101,316,413...101,457,109

G

GC-rich promoter binding protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GPBP1 mRNA

NCBI chr 2:44,756,861...44,824,281
Ensembl chr 2:44,756,861...44,824,315

G

glypican 1

multiple interactions

ISO

[APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form; Zinc affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]; Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form]

PMID:12732622 PMID:15677459

NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:100,843,645...100,879,933

G

glycerophosphocholine phosphodiesterase 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GPCPD1 mRNA

NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:140,240,575...140,285,372

G

glycerol-3-phosphate dehydrogenase 2

affects expression

EXP

Zinc affects the expression of GPD2 mRNA

NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593

G

glycosylphosphatidylinositol specific phospholipase D1

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of GPLD1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of GPLD1 mRNA]

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975

G

G protein-coupled receptor 183

increases expression

ISO

Zinc deficiency results in increased expression of GPR183 mRNA

NCBI chr15:105,445,129...105,457,192
Ensembl chr15:105,437,561...105,466,977

G

G protein-coupled receptor 19

increases expression

EXP

Zinc deficiency results in increased expression of GPR19 mRNA

NCBI chr 4:169,442,278...169,468,805
Ensembl chr 4:169,436,658...169,471,249

G

G protein-coupled receptor 6

decreases expression

ISO

Zinc deficiency results in decreased expression of GPR6 mRNA

NCBI chr20:46,072,480...46,075,251
Ensembl chr20:46,072,453...46,075,875

G

G protein-coupled receptor, class C, group 5, member D

increases expression

ISO

Zinc deficiency results in increased expression of GPRC5D mRNA

NCBI chr 4:169,674,874...169,686,965
Ensembl chr 4:169,674,846...169,686,965

G

G-protein signaling modulator 1

decreases expression

EXP

Zinc deficiency results in decreased expression of GPSM1 mRNA

NCBI chr 3:29,538,929...29,565,921
Ensembl chr 3:29,526,802...29,565,920

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

[Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; [Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in increased activity of GPT protein]; [Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in increased expression of GPT protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; Zinc inhibits the reaction [Glyphosate results in increased expression of GPT protein]
[zinc chloride results in increased abundance of Zinc] which results in increased activity of GPT protein

PMID:20688495 PMID:25067936 PMID:32233808 PMID:36450499 PMID:37676925

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

affects expression
increases expression

EXP

Zinc affects the expression of GPX1 mRNA
Zinc deficiency results in increased expression of GPX1 mRNA

PMID:12672911 PMID:16413754 PMID:20128680

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 4

multiple interactions

EXP

[Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in decreased expression of GPX4 protein]

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutathione peroxidase 5

multiple interactions

EXP

[Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in decreased expression of GPX5 protein]

NCBI chr17:48,131,853...48,138,801
Ensembl chr17:48,093,895...48,138,801

G

growth factor receptor bound protein 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GRB10 mRNA

NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387

G

grainyhead-like transcription factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GRHL1 mRNA

NCBI chr 6:46,935,947...46,986,126
Ensembl chr 6:46,935,967...46,980,264

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

ISO

Zinc results in increased expression of GRIK2 mRNA

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases activity

EXP

Zinc results in decreased activity of GRIN2A protein

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases activity
multiple interactions

EXP

Zinc results in decreased activity of GRIN2B protein
[Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B protein

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

G protein-coupled receptor kinase 1

multiple interactions
decreases expression

EXP

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Zinc results in decreased expression of GRK1 protein]; Metipranolol inhibits the reaction [Zinc results in decreased expression of GRK1 protein]

NCBI chr16:82,821,184...82,837,971
Ensembl chr16:82,826,022...82,837,971

G

glutamate metabotropic receptor 1

decreases expression

ISO

Zinc deficiency results in decreased expression of GRM1 mRNA

NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443

G

glutamate metabotropic receptor 5

decreases expression

ISO

Zinc deficiency results in decreased expression of GRM5 mRNA

NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649

G

GrpE-like 1, mitochondrial

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GRPEL1 mRNA

NCBI chr14:78,517,049...78,522,868
Ensembl chr14:78,517,052...78,522,861

G

glycogen synthase kinase 3 beta

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein; AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]
Zinc deficiency results in decreased phosphorylation of GSK3B protein
Zinc results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]

PMID:17098228 PMID:17513037 PMID:21893222

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

gelsolin

affects binding

ISO

GSN protein binds to Zinc

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850

G

glutathione-disulfide reductase

multiple interactions
decreases activity

EXP

[Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of GSR protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of GSR protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; [Zinc Sulfate results in increased abundance of Zinc] which results in decreased activity of GSR protein; Zinc affects the reaction [sodium arsenite results in decreased activity of GSR protein]; Zinc inhibits the reaction [Indomethacin results in decreased activity of GSR protein]; Zinc inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
Zinc results in decreased activity of GSR protein

PMID:12566098 PMID:22127830 PMID:24184500 PMID:31009641 PMID:32864810

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 4

decreases expression

EXP

Zinc deficiency results in decreased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase alpha 5

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTA5 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GSTA5 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 2

decreases expression

EXP

Zinc deficiency results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase mu 4

increases expression

ISO

Zinc deficiency results in increased expression of GSTM4 mRNA

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638

G

glutathione S-transferase, mu 5

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase, theta 3

increases expression

EXP

Zinc deficiency results in increased expression of GSTT3 mRNA

NCBI chr20:12,873,618...12,881,974
Ensembl chr20:12,874,374...12,881,973

G

general transcription factor IIH subunit 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GTF2H1 mRNA

NCBI chr 1:106,457,692...106,485,729
Ensembl chr 1:106,457,394...106,485,727

G

guanylate cyclase activator 2B

multiple interactions
increases expression

EXP

[Zinc deficiency co-treated with IL1A protein] results in increased expression of GUCA2B mRNA; IL1A protein promotes the reaction [Zinc deficiency results in increased expression of GUCA2B protein]
Zinc deficiency results in increased expression of GUCA2B mRNA; Zinc deficiency results in increased expression of GUCA2B protein

PMID:11260404 PMID:11717422 PMID:12514266

NCBI chr 5:138,532,160...138,534,210
Ensembl chr 5:138,532,178...138,534,235

G

gulonolactone (L-) oxidase

increases expression

EXP

Zinc deficiency results in increased expression of GULO mRNA

NCBI chr15:44,381,226...44,403,314
Ensembl chr15:44,381,214...44,403,422

G

glycophorin A

decreases expression

ISO

Zinc deficiency results in decreased expression of GYPA mRNA

NCBI chr19:44,354,669...44,370,304
Ensembl chr19:44,354,706...44,370,291

G

GDNF-inducible zinc finger protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of GZF1 mRNA

NCBI chr 3:156,572,152...156,584,369
Ensembl chr 3:156,572,250...156,584,363

G

granzyme K

decreases expression

ISO

Zinc deficiency results in decreased expression of GZMK mRNA

NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015

G

H2A clustered histone 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of H2AC6 mRNA

NCBI chr17:47,403,701...47,404,167

G

H2A.X variant histone

increases expression
multiple interactions

ISO
EXP

Zinc deficiency results in increased expression of H2AX mRNA
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein

PMID:18356318 PMID:31542844

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H2B clustered histone 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of H2BC8 mRNA

NCBI chr17:47,404,405...47,405,155

G

H3.3 histone B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of H3-3B mRNA

NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,755,404...101,757,636

G

2-hydroxyacyl-CoA lyase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of HACL1 mRNA

NCBI chr16:6,831,293...6,869,410
Ensembl chr16:6,833,268...6,869,410

G

hydroxyacyl-CoA dehydrogenase

decreases expression

EXP

Zinc deficiency results in decreased expression of HADH protein

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

EXP

Zinc deficiency results in decreased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

histidine ammonia lyase

decreases expression

ISO

Zinc deficiency results in decreased expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

HUWE1 associated protein modifying stress responses

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HAPSTR1 mRNA

NCBI chr10:7,252,737...7,281,678
Ensembl chr10:7,252,737...7,281,678

G

hepatitis A virus cellular receptor 1

decreases expression

ISO

Zinc results in decreased expression of HAVCR1 mRNA

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

hemoglobin alpha, adult chain 3

affects binding

ISO

HBA2 protein binds to Zinc

NCBI chr10:15,816,099...15,816,943
Ensembl chr10:15,816,096...15,817,167

G

hemoglobin subunit beta

affects binding

ISO

HBB protein binds to Zinc

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

heparin-binding EGF-like growth factor

multiple interactions
increases secretion
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HBEGF mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of HBEGF mRNA; HBEGF protein affects the reaction [Zinc results in increased phosphorylation of EGFR protein]; N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid inhibits the reaction [Zinc results in increased secretion of HBEGF protein]
Zinc results in increased expression of HBEGF mRNA

PMID:12972402 PMID:16979875 PMID:18593933

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

HMG-box transcription factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:54,256,864...54,283,366

G

HBS1-like translational GTPase

increases expression

ISO

Zinc deficiency results in increased expression of HBS1L mRNA

NCBI chr 1:17,912,139...17,989,651
Ensembl chr 1:17,912,070...17,989,646

G

histone deacetylase 1

multiple interactions

ISO

Zinc binds to and results in increased activity of HDAC1 protein
[zinc chloride results in increased abundance of Zinc] which results in decreased expression of HDAC1 mRNA

PMID:16439135 PMID:31588059

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

histone deacetylase 4

multiple interactions

ISO

Zinc binds to and results in increased activity of HDAC4 protein

NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637

G

histone deacetylase 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HDAC5 mRNA

NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244

G

histone deacetylase 6

multiple interactions

ISO

Zinc binds to and results in increased activity of HDAC6 protein

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

histone deacetylase 8

affects binding

ISO

Zinc binds to HDAC8 protein

NCBI chr X:71,425,240...71,632,865
Ensembl chr X:71,394,928...71,632,865

G

hephaestin

decreases expression
increases expression
multiple interactions

EXP

Zinc results in decreased expression of HEPH protein
Zinc results in increased expression of HEPH protein
[Zinc results in decreased expression of HEPH protein] which results in decreased uptake of Iron

NCBI chr X:65,160,628...65,412,457
Ensembl chr X:65,305,773...65,412,453

G

HECT and RLD domain containing E3 ubiquitin protein ligase 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HERC4 mRNA

NCBI chr20:25,329,005...25,403,443
Ensembl chr20:25,328,822...25,403,372

G

homocysteine inducible ER protein with ubiquitin like domain 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

homeostatic iron regulator

affects abundance

ISO

HFE protein affects the abundance of Zinc

NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,841,252...41,851,208

G

hepatocyte growth factor

multiple interactions

ISO

[Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA]

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

[Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; [Zinc results in decreased localization of ARNT protein] inhibits the reaction [ARNT protein binds to HIF1A protein]; [Zinc results in increased expression of HIF1A mRNA alternative form] which results in decreased localization of ARNT protein; Zinc inhibits the reaction [ARNT protein binds to HIF1A protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]
Zinc results in increased expression of HIF1A protein

PMID:11739637 PMID:16330433 PMID:16579968 PMID:16973622

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

histidine triad nucleotide binding protein 1

multiple interactions

ISO

Zinc promotes the reaction [RAF1 protein binds to PRKCG protein binds to HINT1 protein]

NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642

G

Holliday junction recognition protein

increases expression

ISO

Zinc deficiency results in increased expression of HJURP mRNA

NCBI chr 9:96,301,183...96,315,587
Ensembl chr 9:96,302,530...96,315,657

G

hemojuvelin BMP co-receptor

decreases expression

EXP

Zinc deficiency results in decreased expression of HJV mRNA

NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:186,754,811...186,758,867

G

hexokinase 1

decreases expression

EXP

Zinc results in decreased expression of HK1 mRNA

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814

G

high mobility group 20A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HMG20A mRNA

NCBI chr 8:65,715,688...65,791,663
Ensembl chr 8:65,715,219...65,791,608

G

high mobility group 20 B

decreases expression

ISO

Zinc deficiency results in decreased expression of HMG20B mRNA

NCBI chr 7:9,019,670...9,024,382
Ensembl chr 7:9,019,698...9,024,377

G

high mobility group AT-hook 1

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of HMGA1 mRNA

NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593

G

high mobility group box 2

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of HMGB2 mRNA; Zinc deficiency results in increased expression of HMGB2 protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of HMGB2 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of HMGB2 protein]

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

3-hydroxy-3-methylglutaryl-CoA reductase

affects expression
decreases expression

EXP

Zinc affects the expression of HMGCR mRNA
Zinc deficiency results in decreased expression of HMGCR mRNA; Zinc results in decreased expression of HMGCR mRNA

PMID:15671213 PMID:17074742 PMID:17181878

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of HMGCS2 protein

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

heme oxygenase 1

increases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of HMOX1 mRNA
Zinc results in increased expression of HMOX1 mRNA; Zinc results in increased expression of HMOX1 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]; [PCI 5002 co-treated with Zinc] results in increased expression of HMOX1 mRNA; [Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 protein]; CAT protein inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]; Deferoxamine inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]; Deferoxamine inhibits the reaction [Zinc results in increased expression of HMOX1 protein]; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of HMOX1 mRNA]; Zinc deficiency promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter]
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of HMOX1 mRNA; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; [Taurine binds to Zinc] which results in decreased expression of HMOX1 mRNA; [Taurine binds to Zinc] which results in increased expression of HMOX1 protein; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of HMOX1 protein]; Zinc deficiency inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HMOX1 mRNA]
Zinc deficiency results in increased expression of HMOX1 mRNA; Zinc results in increased expression of HMOX1 mRNA
NFE2L2 protein affects the reaction [Zinc results in increased expression of HMOX1 mRNA]

PMID:10473555 PMID:16870260 PMID:17074742 PMID:17244614 PMID:18593933 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

HNF1 homeobox A

affects expression
multiple interactions

ISO

Zinc deficiency affects the expression of HNF1A mRNA
[Zinc deficiency co-treated with Ethanol] results in increased expression of HNF1A mRNA

NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755

G

hepatocyte nuclear factor 4, alpha

multiple interactions

ISO

Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein]
[Ethanol co-treated with Zinc] results in increased expression of HNF4A mRNA; Zinc inhibits the reaction [Ethanol results in decreased activity of HNF4A protein]

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

histamine N-methyltransferase

decreases expression

ISO

Zinc deficiency results in decreased expression of HNMT mRNA

NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482

G

heterogeneous nuclear ribonucleoprotein H1

increases expression

ISO

Zinc deficiency results in increased expression of HNRNPH1 mRNA

NCBI chr10:35,187,412...35,203,909
Ensembl chr10:35,193,890...35,203,906

G

homer scaffold protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HOMER1 mRNA

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

HOP homeobox

decreases expression

ISO

Zinc deficiency results in decreased expression of HOPX mRNA

NCBI chr14:31,410,235...31,437,189
Ensembl chr14:31,410,221...31,437,188

G

homeo box C10

decreases expression

ISO

Zinc deficiency results in decreased expression of HOXC10 mRNA

PMID:12561611 PMID:18356318

NCBI chr 7:135,982,222...135,987,442
Ensembl chr 7:135,982,065...135,986,712

G

haptoglobin

affects binding

ISO

HP protein binds to Zinc

NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518

G

hippocalcin-like 1

increases expression

ISO

Zinc deficiency results in increased expression of HPCAL1 mRNA

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

15-hydroxyprostaglandin dehydrogenase

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of HPGD mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of HPGD mRNA]

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831

G

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HPS5 mRNA

NCBI chr 1:106,417,902...106,457,220
Ensembl chr 1:106,417,902...106,452,859

G

hemopexin

affects binding

ISO

HPX protein binds to Zinc

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

histidine rich calcium binding protein

decreases expression

EXP

Zinc deficiency results in decreased expression of HRC mRNA

NCBI chr 1:104,949,750...104,953,475
Ensembl chr 1:104,949,741...104,954,193

G

histidine-rich glycoprotein

increases activity
affects binding
multiple interactions

ISO

Zinc results in increased activity of HRG protein
HRG protein binds to Zinc
Heparin inhibits the reaction [Zinc results in increased activity of HRG protein]

PMID:8690451 PMID:23896426

NCBI chr11:91,559,087...91,573,982
Ensembl chr11:91,559,091...91,573,982

G

histamine receptor H 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HRH1 mRNA

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

harakiri, BCL2 interacting protein

decreases expression

ISO

Zinc deficiency results in decreased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561

G

hornerin

affects binding

ISO

HRNR protein binds to Zinc

NCBI chr 2:181,650,772...181,663,633

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of HSD11B2 mRNA

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

EXP

Zinc deficiency results in decreased expression of HSD17B10 protein

NCBI chr X:24,568,551...24,571,012
Ensembl chr X:24,568,551...24,574,681

G

hydroxysteroid (17-beta) dehydrogenase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of HSD17B2 mRNA

NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943

G

hydroxysteroid (17-beta) dehydrogenase 7

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSD17B7 mRNA

NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754

G

heat shock transcription factor 1

increases activity
multiple interactions

ISO

Zinc deficiency results in increased activity of HSF1 protein; Zinc results in increased activity of HSF1 protein
Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter]; Zinc promotes the reaction [HSF1 protein binds to HSPA1A enhancer]; Zinc promotes the reaction [HSF1 protein binds to HSPA1A promoter]; Zinc promotes the reaction [MTF1 protein binds to HSF1 protein]

PMID:16460681 PMID:17244614 PMID:18356318

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock transcription factor 2

decreases expression

ISO

Zinc deficiency results in decreased expression of HSF2 mRNA

NCBI chr20:37,366,301...37,393,922
Ensembl chr20:37,366,279...37,401,022

G

heat shock transcription factor 5

decreases expression

ISO

Zinc deficiency results in decreased expression of HSF5 mRNA

NCBI chr10:72,913,730...72,957,649
Ensembl chr10:72,914,382...72,957,648

G

heat shock protein 90 alpha family class A member 1

decreases expression
multiple interactions

EXP
ISO

Zinc results in decreased expression of HSP90AA1 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of HSP90AA1 mRNA

PMID:17074742 PMID:18593933

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 beta family member 1

increases expression

ISO

Zinc deficiency results in increased expression of HSP90B1 mRNA

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of HSPA1A mRNA; Zinc promotes the reaction [HSF1 protein binds to HSPA1A enhancer]; Zinc promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Zinc results in increased expression of HSPA1A mRNA
Zinc results in increased expression of HSPA1A mRNA; Zinc results in increased expression of HSPA1A protein

PMID:15159208 PMID:16460681 PMID:16870260 PMID:16949620 PMID:17244614 More...

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

affects abundance
multiple interactions

ISO

HSPA1B gene SNP affects the abundance of Zinc
[PCI 5002 co-treated with Zinc] results in increased expression of HSPA1B mRNA

PMID:16513158 PMID:18593933

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPA1L mRNA

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

heat shock protein family A (Hsp70) member 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 4 like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:125,668,236...125,720,986

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP
ISO

Zinc inhibits the reaction [lead acetate binds to HSPA5 protein]
[PCI 5002 co-treated with Zinc] results in increased expression of HSPA5 mRNA

PMID:10702365 PMID:18593933

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression
multiple interactions

ISO

Zinc results in increased expression of HSPA6 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of HSPA6 mRNA

PMID:16870260 PMID:18593933

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family B (small) member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family B (small) member 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family H (Hsp110) member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

5-hydroxytryptamine receptor 7

increases expression

ISO

Zinc deficiency results in increased expression of HTR7 mRNA

NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230

G

hypoxia up-regulated 1

increases expression

ISO

Zinc deficiency results in increased expression of HYOU1 mRNA

NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:53,602,604...53,614,997

G

islet amyloid polypeptide

multiple interactions

ISO

Zinc affects the reaction [IDE protein affects the degradation of IAPP protein]

NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:176,968,097...176,975,363

G

integrin-binding sialoprotein

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IBSP mRNA

NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299

G

intercellular adhesion molecule 1

affects expression
increases expression
multiple interactions

ISO

Zinc affects the expression of ICAM1 mRNA
Zinc deficiency results in increased expression of ICAM1 mRNA
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA]
Zinc deficiency results in increased expression of ICAM1 mRNA; Zinc results in increased expression of ICAM1 mRNA; Zinc results in increased expression of ICAM1 protein
Zinc deficiency promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Zinc deficiency promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of ICAM1 protein]

PMID:7893746 PMID:16606632 PMID:16979875 PMID:23503329 PMID:30635848

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

intercellular adhesion molecule 2

decreases expression

ISO

Zinc deficiency results in decreased expression of ICAM2 mRNA

NCBI chr10:91,808,449...91,819,319
Ensembl chr10:91,808,316...91,815,072

G

inhibitor of DNA binding 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

inhibitor of DNA binding 3

affects expression

ISO

Zinc affects the expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

inhibitor of DNA binding 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ID4 mRNA

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

insulin degrading enzyme

multiple interactions
decreases activity

ISO
EXP

Zinc affects the reaction [IDE protein affects the degradation of IAPP protein]
Zinc results in decreased activity of IDE protein

NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526

G

isocitrate dehydrogenase (NADP(+)) 1

increases expression

EXP

Zinc results in increased expression of IDH1 mRNA

NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555

G

isopentenyl-diphosphate delta isomerase 1

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of IDI1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of IDI1 mRNA]

PMID:16140947 PMID:18593933

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

indoleamine 2,3-dioxygenase 1

decreases expression

ISO

Zinc results in decreased expression of INDO mRNA

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328

G

immediate early response 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IER2 mRNA

NCBI chr19:40,399,373...40,400,897
Ensembl chr19:40,398,160...40,402,708

G

immediate early response 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IER3 mRNA

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

immediate early response 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IER5 mRNA

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:69,820,451...69,822,543

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of IFIT2 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of IFIT2 mRNA]

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:241,515,709...241,521,798

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of IFIT3 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of IFIT3 mRNA]

NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521

G

interferon, alpha 1

affects abundance

ISO

IFNA1 protein affects the abundance of Zinc

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interferon alpha and beta receptor subunit 1

decreases expression

ISO

Zinc results in decreased expression of IFNAR1 mRNA

NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205

G

interferon alpha and beta receptor subunit 2

increases expression

ISO

Zinc deficiency results in increased expression of IFNAR2 mRNA

NCBI chr11:44,099,574...44,131,941
Ensembl chr11:44,099,753...44,131,937

G

interferon gamma

multiple interactions
increases expression
decreases uptake
decreases expression
increases secretion

ISO

[IFNG protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc; [Zinc co-treated with Lipopolysaccharides] results in increased expression of IFNG mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased secretion of IFNG protein]; Zinc deficiency affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]
[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc; [zinc chloride results in increased abundance of Zinc] which results in decreased expression of IFNG mRNA; MT1 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; MT2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; NOS2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]
Zinc results in increased expression of IFNG mRNA; Zinc results in increased expression of IFNG protein
IFNG protein results in decreased uptake of Zinc
Zinc results in decreased expression of IFNG protein

PMID:12812920 PMID:14617770 PMID:14624943 PMID:16434472 PMID:16472982 More...

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon-related developmental regulator 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IFRD1 mRNA

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

insulin-like growth factor 1

increases import
multiple interactions
increases expression
decreases expression

ISO
EXP

IGF1 protein results in increased import of Zinc
Zinc promotes the reaction [IGF1 protein binds to IGF1R protein]
[Zinc binds to calcium silicate] which results in increased expression of IGF1 mRNA
Zinc deficiency results in increased expression of IGF1 mRNA; Zinc deficiency results in increased expression of IGF1 protein
Zinc deficiency results in decreased expression of IGF1 mRNA; Zinc deficiency results in decreased expression of IGF1 protein

PMID:7722689 PMID:9648927 PMID:10985758 PMID:12672911 PMID:15990634 More...

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

affects expression
multiple interactions
increases phosphorylation
decreases expression

EXP
ISO

Zinc affects the expression of IGF1R mRNA
Zinc promotes the reaction [IGF1 protein binds to IGF1R protein]; Zinc promotes the reaction [IGF2 protein binds to IGF1R protein]
Zinc results in increased phosphorylation of IGF1R protein
Zinc deficiency results in decreased expression of IGF1R mRNA; Zinc deficiency results in decreased expression of IGF1R protein
Zinc results in decreased expression of IGF1R protein

PMID:9648927 PMID:14644152 PMID:16413754 PMID:19913001 PMID:21893222

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor 2

multiple interactions

ISO

Zinc promotes the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression
affects binding

EXP
ISO

Zinc deficiency results in decreased expression of IGFALS mRNA
IGFALS protein binds to Zinc

PMID:12672911 PMID:23896426

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 1

decreases expression

EXP

Zinc deficiency results in decreased expression of IGFBP1 mRNA; Zinc deficiency results in decreased expression of IGFBP1 protein

PMID:12672911 PMID:20404036

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

decreases expression

EXP

Zinc deficiency results in decreased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 3

increases expression
decreases expression

ISO
EXP

Zinc results in increased expression of IGFBP3 protein
Zinc deficiency results in increased expression of IGFBP3 mRNA
Zinc deficiency results in decreased expression of IGFBP3 protein

PMID:10985758 PMID:15990634 PMID:19913001

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

insulin-like growth factor binding protein 4

decreases expression

EXP

Zinc deficiency results in decreased expression of IGFBP4 protein

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

insulin-like growth factor binding protein 5

multiple interactions
decreases expression
decreases degradation

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGFBP5 mRNA
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA
Zinc deficiency results in decreased expression of IGFBP5 mRNA
Zinc results in decreased degradation of IGFBP5 protein

PMID:8894652 PMID:16979875 PMID:20128680 PMID:23859036

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390

G

insulin-like growth factor binding protein 7

affects expression
multiple interactions

ISO

Zinc affects the expression of IGFBP7 mRNA
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGFBP7 mRNA

NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620

G

gamma-2a immunoglobulin heavy chain

affects binding

ISO

IGHG4 protein binds to Zinc

G

immunoglobulin heavy constant gamma 1

affects binding

ISO

IGHG1 protein binds to Zinc

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions
affects expression

ISO

[Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of BCL2 protein; [Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of NFKB1 protein; Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]
Zinc affects the expression of IKBKB mRNA

PMID:16979875 PMID:17029595

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions
decreases expression
increases expression
decreases secretion

ISO
EXP

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in decreased secretion of IL10 protein]
Zinc deficiency results in decreased expression of IL10 mRNA
Zinc deficiency results in increased expression of IL10 mRNA; Zinc results in increased expression of IL10 mRNA
Zinc results in decreased expression of IL10 mRNA; Zinc results in decreased expression of IL10 protein

PMID:10938463 PMID:12888634 PMID:17150331 PMID:17622302 PMID:18842795

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 11

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915

G

interleukin 12 receptor subunit beta 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL12RB2 mRNA

NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937

G

interleukin 1 alpha

increases expression
multiple interactions
increases uptake
affects metabolic processing
increases abundance

EXP
ISO

Zinc results in increased expression of IL1A mRNA
Zinc promotes the reaction [IL1A protein results in increased expression of MT2A mRNA]
IL1A protein results in increased uptake of Zinc
IL1A protein affects the metabolism of Zinc
[IL1A protein co-treated with Zinc deficiency] results in increased expression of NOS2 protein; [Zinc deficiency co-treated with IL1A protein] results in increased expression of GUCA2B mRNA; [Zinc deficiency co-treated with IL1A protein] results in increased expression of NOS2 mRNA; IL1A protein inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA]; IL1A protein promotes the reaction [Zinc deficiency results in increased expression of GUCA2B protein]; IL1A protein promotes the reaction [Zinc deficiency results in increased expression of NOS2 mRNA]; Zinc deficiency inhibits the reaction [IL1A protein results in increased expression of MT1A mRNA]
IL1A protein results in increased abundance of Zinc

PMID:1502195 PMID:2458983 PMID:9278552 PMID:9649590 PMID:12514266 More...

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases secretion
increases expression
decreases expression
increases uptake

ISO
EXP

[Zinc co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL1B mRNA]; Mitomycin affects the reaction [IL1B protein results in increased uptake of Zinc]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1B mRNA]; Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B protein]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of IL1B protein]; Zinc promotes the reaction [IL1B protein results in increased expression of MT2A mRNA]
[[Taurine binds to Zinc] which co-treated with poly(N-vinylpyrrolidine)] results in decreased expression of IL1B protein; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of IL1B protein]; Paraquat promotes the reaction [Zinc results in increased expression of IL1B protein]; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]; Zinc promotes the reaction [Paraquat results in increased expression of IL1B protein]
Zinc results in increased secretion of IL1B protein
Zinc results in increased expression of IL1B mRNA; Zinc results in increased expression of IL1B protein
Zinc deficiency results in decreased expression of IL1B mRNA
Zinc deficiency results in increased expression of IL1B mRNA; Zinc deficiency results in increased expression of IL1B protein; Zinc results in increased expression of IL1B protein
[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc; [Zinc deficiency co-treated with Ethanol] results in increased expression of IL1B mRNA; MT1 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; MT2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; NOS2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]
Zinc results in decreased expression of IL1B protein

PMID:1502195 PMID:2107032 PMID:8980878 PMID:12812920 PMID:14617770 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

increases expression

EXP

Zinc deficiency results in increased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 1 receptor type 2

multiple interactions
decreases expression

ISO

IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]

NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374

G

interleukin 1 receptor accessory protein

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL1RAP mRNA

NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342

G

interleukin 1 receptor accessory protein-like 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL1RAPL2 mRNA

NCBI chr X:105,547,403...107,080,369
Ensembl chr X:105,754,490...107,065,223

G

interleukin 1 receptor antagonist

increases expression

ISO

Zinc results in increased expression of IL1RN protein

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 2

affects expression
affects localization
multiple interactions
decreases expression
increases expression

ISO
EXP

Zinc affects the expression of IL2 mRNA; Zinc affects the expression of IL2 protein
IL2 protein affects the localization of Zinc
Zinc deficiency affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]
Zinc deficiency results in decreased expression of IL2
Zinc deficiency results in decreased expression of IL2 mRNA
Zinc results in increased expression of IL2 mRNA; Zinc results in increased expression of IL2 protein

PMID:12389026 PMID:12672911 PMID:12812920 PMID:16930873 PMID:17162254 More...

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 24

decreases expression

ISO

Zinc results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 2 receptor subunit alpha

affects expression
multiple interactions
increases expression

ISO

Zinc affects the expression of IL2RA mRNA; Zinc affects the expression of IL2RA protein
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2RA mRNA
Zinc results in increased expression of IL2RA mRNA

PMID:16930873 PMID:16979875 PMID:17162254

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 3

multiple interactions
affects binding

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL3 mRNA
Zinc binds to IL3 protein

PMID:1530641 PMID:16979875

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810

G

interleukin 4

decreases expression
multiple interactions

ISO

Zinc results in decreased expression of IL4 protein
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA

PMID:14624943 PMID:16979875

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 4 receptor

increases expression

ISO

Zinc deficiency results in increased expression of IL4R mRNA

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 6

affects abundance
increases expression
decreases expression
increases uptake
multiple interactions

ISO
EXP

IL6 gene SNP affects the abundance of Zinc; IL6 promoter SNP affects the abundance of Zinc
Zinc deficiency results in increased expression of IL6 mRNA
Zinc deficiency results in increased expression of IL6 mRNA; Zinc results in increased expression of IL6 protein
Zinc results in decreased expression of IL6 mRNA; Zinc results in decreased expression of IL6 protein
IL6 protein results in increased uptake of Zinc
Zinc results in increased expression of IL6 mRNA; Zinc results in increased expression of IL6 protein
[Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased secretion of IL6 protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; [Thymic Factor, Circulating co-treated with Zinc] results in increased secretion of IL6 protein; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Paraquat promotes the reaction [Zinc results in increased expression of IL6 protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Zinc promotes the reaction [Paraquat results in increased expression of IL6 protein]
[Zinc co-treated with Aluminum] results in increased expression of IL6 protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of FABP4 mRNA]; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL1B mRNA]; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL6 mRNA]; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL6 protein]; IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL6 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL6 protein]; Zinc deficiency promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Zinc inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of IL6 mRNA]; Zinc promotes the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Zinc promotes the reaction [FCER1A protein results in increased expression of IL6 protein]

PMID:12639846 PMID:15159208 PMID:16472982 PMID:16513158 PMID:16606632 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IL6R mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL6R mRNA

PMID:16979875 PMID:18593933

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interleukin 6 cytokine family signal transducer

multiple interactions

ISO

Zinc inhibits the reaction [TNF protein results in increased secretion of IL6ST protein]

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

interleukin 9

decreases expression

ISO

Zinc deficiency results in decreased expression of IL9 mRNA

NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,117,028...8,120,151

G

interleukin 9 receptor

affects expression
multiple interactions

ISO

Zinc affects the expression of IL9R mRNA
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL9R mRNA

NCBI chr10:15,936,156...15,947,613
Ensembl chr10:15,936,156...15,947,613

G

integrin-linked kinase

decreases expression

ISO

Zinc results in decreased expression of ILK mRNA

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

inhibitor of growth family, member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ING1 mRNA

NCBI chr16:84,639,378...84,649,498
Ensembl chr16:84,639,381...84,647,616

G

inhibin subunit beta A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

inhibin subunit beta C

decreases expression

ISO

Zinc deficiency results in decreased expression of INHBC mRNA

NCBI chr 7:65,069,450...65,082,919
Ensembl chr 7:65,069,451...65,082,919

G

inositol polyphosphate-1-phosphatase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of INPP1 mRNA

NCBI chr 9:56,161,816...56,209,774
Ensembl chr 9:56,161,852...56,234,569

G

inositol polyphosphate-4-phosphatase type I A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of INPP4A mRNA

NCBI chr 9:47,024,064...47,142,391
Ensembl chr 9:47,087,471...47,135,968

G

inositol polyphosphate-4-phosphatase type II B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of INPP4B mRNA

NCBI chr19:42,824,710...43,575,039
Ensembl chr19:42,829,871...43,185,091

G

insulin 1

increases expression
multiple interactions
increases secretion
decreases expression

ISO
EXP

Zinc results in increased expression of INS1 protein
Zinc deficiency results in increased expression of INS1 mRNA
7-nitroindazole inhibits the reaction [[INS1 protein co-treated with Glucose] results in increased transport of Zinc]; [[valyl-histidyl-threonyl-aspartamide binds to Zinc] results in increased activity of [INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein]] which results in decreased abundance of C-Peptide; [[valyl-histidyl-threonyl-aspartamide binds to Zinc] results in increased activity of [INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein]] which results in decreased abundance of Glucose; [INS1 protein co-treated with Glucose] results in increased transport of Zinc; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Zinc deficiency results in increased expression of INS1 mRNA]; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Zinc deficiency results in increased secretion of INS1 protein]; [valyl-histidyl-threonyl-aspartamide binds to Zinc] results in increased activity of [INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein binds to INS1 protein]; [Zinc co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [Zinc co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; Zinc inhibits the reaction [Glucose results in increased secretion of INS1 protein]
Zinc deficiency results in decreased expression of INS1 protein
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL5 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL7 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL9 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL5 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP1A mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP9 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL24 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL25 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL27 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CKLF mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL10 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL10 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL7 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL5 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP1A mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA]; Zinc promotes the reaction [INS1 protein results in increased uptake of Glucose]

PMID:1321133 PMID:15516700 PMID:15919803 PMID:18545258 PMID:19463741 More...

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

affects binding

ISO

Zinc binds to INS protein; Zinc binds to INS protein binds to INS protein

PMID:16362452 PMID:16969698

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

insulin induced gene 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

INSM transcriptional repressor 1

decreases expression

ISO

Zinc deficiency results in decreased expression of INSM1 mRNA

NCBI chr 3:154,093,310...154,096,243
Ensembl chr 3:154,092,734...154,096,047

G

insulin receptor

affects expression
decreases expression
increases phosphorylation
multiple interactions

EXP
ISO

Zinc affects the expression of INSR mRNA
Zinc deficiency results in decreased expression of INSR mRNA; Zinc deficiency results in decreased expression of INSR protein
Zinc results in increased phosphorylation of INSR protein
Chromium promotes the reaction [Zinc results in increased phosphorylation of INSR protein]; Zinc promotes the reaction [Chromium results in increased phosphorylation of INSR protein]
[Zinc co-treated with INS1 protein] results in increased phosphorylation of INSR protein

PMID:1321133 PMID:15516700 PMID:16413754 PMID:21893222

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

integrator complex subunit 3

increases expression

ISO

Zinc deficiency results in increased expression of INTS3 mRNA

NCBI chr 2:178,157,015...178,209,263
Ensembl chr 2:178,157,015...178,209,137

G

inversin

decreases expression

ISO

Zinc deficiency results in decreased expression of INVS mRNA

NCBI chr 5:67,406,511...67,559,355
Ensembl chr 5:67,406,485...67,559,350

G

inositol hexakisphosphate kinase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IP6K2 mRNA

NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:118,362,795...118,388,667

G

IQ motif containing E

decreases expression

ISO

Zinc results in decreased expression of IQCE mRNA

NCBI chr12:19,057,060...19,096,626
Ensembl chr12:19,056,307...19,096,624

G

interleukin-1 receptor-associated kinase 1 binding protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IRAK1BP1 mRNA

NCBI chr 8:92,608,468...92,628,377
Ensembl chr 8:92,611,843...92,628,377

G

interleukin-1 receptor-associated kinase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IRAK2 mRNA

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210

G

interleukin-1 receptor-associated kinase 3

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IRAK3 mRNA

NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706

G

iron responsive element binding protein 2

multiple interactions
increases expression

ISO
EXP

[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]; Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]; etiron promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of IREB2 protein]; Zinc deficiency results in increased expression of and results in increased activity of IREB2 protein
Zinc deficiency results in increased expression of IREB2 mRNA

PMID:18073202 PMID:24024381

NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520

G

interferon regulatory factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

interferon regulatory factor 4

increases expression

ISO

Zinc deficiency results in increased expression of IRF4 mRNA

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730

G

interferon regulatory factor 9

increases expression

ISO

Zinc deficiency results in increased expression of IRF9 mRNA

NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879

G

insulin receptor substrate 1

decreases expression
increases phosphorylation

ISO
EXP

Zinc results in decreased expression of IRS1 protein
Zinc results in increased phosphorylation of IRS1 protein

PMID:14644152 PMID:15516700 PMID:19913001

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

insulin receptor substrate 2

decreases expression
multiple interactions

ISO

Zinc results in decreased expression of IRS2 protein
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA

PMID:19913001 PMID:33549593

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

insulin receptor substrate 4

multiple interactions

EXP

[Zinc co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein

NCBI chr X:110,132,490...110,148,473
Ensembl chr X:110,132,405...110,149,088

G

iron-sulfur cluster assembly 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ISCA1 mRNA

NCBI chr17:4,910,816...4,923,478
Ensembl chr17:4,910,795...4,923,476

G

ISL LIM homeobox 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ISL2 mRNA

NCBI chr 8:64,819,879...64,824,864
Ensembl chr 8:64,819,879...64,824,864

G

itchy E3 ubiquitin protein ligase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ITCH mRNA

NCBI chr 3:164,102,490...164,193,932
Ensembl chr 3:164,105,812...164,193,932

G

integrin subunit alpha 1

affects expression

ISO

Zinc affects the expression of ITGA1 mRNA

NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:48,386,249...48,545,284

G

integrin subunit alpha 2

decreases expression

ISO

Zinc results in decreased expression of ITGA2 mRNA

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509

G

integrin subunit alpha 3

decreases expression

ISO

Zinc results in decreased expression of ITGA3 mRNA

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901

G

integrin subunit alpha 8

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGA8 mRNA

NCBI chr17:80,213,139...80,410,633
Ensembl chr17:80,213,143...80,410,633

G

integrin subunit alpha M

multiple interactions

ISO

[Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit alpha V

decreases expression

ISO

Zinc results in decreased expression of ITGAV mRNA

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

integrin subunit alpha X

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ITGAX mRNA
Zinc results in increased expression of ITGAX mRNA

PMID:16979875 PMID:19071009

NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151

G

integrin subunit beta 1

increases expression

ISO

Zinc deficiency results in increased expression of ITGB1 mRNA

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 2

decreases expression

ISO

Zinc results in decreased expression of ITGB2 mRNA

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

integrin subunit beta 4

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGB4 mRNA

NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932

G

integrin subunit beta 6

decreases expression
increases expression
multiple interactions

ISO

Zinc results in decreased expression of ITGB6 mRNA
Zinc results in increased expression of ITGB6 mRNA
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ITGB6 mRNA

PMID:16870260 PMID:16979875 PMID:19071009

NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333

G

integrin subunit beta 8

increases expression

ISO

Zinc results in increased expression of ITGB8 mRNA

NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:146,165,484...146,351,245

G

inter-alpha trypsin inhibitor, heavy chain 1

affects binding

ISO

ITIH1 protein binds to Zinc

NCBI chr16:6,128,696...6,142,813
Ensembl chr16:6,128,698...6,142,853

G

inter-alpha-trypsin inhibitor heavy chain 2

affects binding

ISO

ITIH2 protein binds to Zinc

NCBI chr17:73,285,281...73,321,555
Ensembl chr17:73,285,270...73,321,547

G

inter-alpha trypsin inhibitor, heavy chain 3

affects binding

ISO

ITIH3 protein binds to Zinc

NCBI chr16:6,108,378...6,123,609
Ensembl chr16:6,108,382...6,123,374

G

inter-alpha-trypsin inhibitor heavy chain 4

affects binding

ISO

ITIH4 protein binds to Zinc

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160

G

integral membrane protein 2C

increases expression

ISO

Zinc deficiency results in increased expression of ITM2C mRNA

NCBI chr 9:93,993,922...94,007,737
Ensembl chr 9:93,993,895...94,007,704

G

inositol 1,4,5-trisphosphate receptor interacting protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ITPRIP mRNA

NCBI chr 1:256,704,087...256,727,661
Ensembl chr 1:256,699,832...256,727,644

G

involucrin

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of IVL mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of IVL mRNA]

NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578

G

Janus kinase 3

increases expression

ISO

Zinc results in increased expression of JAK3 mRNA

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222

G

jumonji and AT-rich interaction domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JARID2 mRNA

NCBI chr17:19,983,217...20,163,598
Ensembl chr17:19,983,217...20,161,970

G

joining chain of multimeric IgA and IgM

affects binding
increases expression

ISO

JCHAIN protein binds to Zinc
Zinc deficiency results in increased expression of JCHAIN mRNA

PMID:22171008 PMID:23896426

NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,822,976...19,838,307

G

Jun dimerization protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JDP2 mRNA

NCBI chr 6:110,988,927...111,033,392
Ensembl chr 6:110,992,806...111,033,392

G

jumonji domain containing 1C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JMJD1C mRNA

NCBI chr20:21,330,990...21,508,580
Ensembl chr20:21,330,990...21,461,916

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JMJD6 mRNA

NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986

G

junction mediating and regulatory protein, p53 cofactor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JMY mRNA

NCBI chr 2:26,401,047...26,465,959
Ensembl chr 2:26,409,969...26,465,649

G

Josephin domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JOSD1 mRNA

NCBI chr 7:113,110,709...113,124,632
Ensembl chr 7:113,110,717...113,124,632

G

Josephin domain containing 2

increases expression

ISO

Zinc results in increased expression of JOSD2 mRNA

NCBI chr 1:104,097,382...104,101,271
Ensembl chr 1:104,097,376...104,101,277

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases phosphorylation
increases activity

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of JUN mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased activity of JUN protein]
[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein; [Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]
Zinc deficiency results in decreased expression of JUN mRNA
Zinc results in increased phosphorylation of JUN protein

PMID:16373669 PMID:16606632 PMID:18593933 PMID:21893222 PMID:28035397 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of JUNB mRNA
Zinc deficiency results in increased expression of JUNB mRNA

PMID:18593933 PMID:19111725

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

junction plakoglobin

affects binding

ISO

JUP protein binds to Zinc

NCBI chr10:85,800,812...85,827,881
Ensembl chr10:85,800,814...85,827,429

G

KN motif and ankyrin repeat domains 2

decreases expression

ISO

Zinc deficiency results in decreased expression of KANK2 mRNA

NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:28,587,770...28,616,993

G

KAT8 regulatory NSL complex subunit 2

decreases expression

ISO

Zinc deficiency results in decreased expression of KANSL2 mRNA

NCBI chr 7:131,548,062...131,564,876
Ensembl chr 7:131,548,062...131,564,753

G

lysine acetyltransferase 8

increases expression

ISO

Zinc results in increased expression of KAT8 mRNA

NCBI chr 1:191,954,827...191,967,107
Ensembl chr 1:191,954,438...191,967,105

G

kelch repeat and BTB domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KBTBD2 mRNA

NCBI chr 4:87,358,133...87,380,399
Ensembl chr 4:87,358,133...87,380,399

G

kelch repeat and BTB domain containing 6

decreases expression

ISO

Zinc deficiency results in decreased expression of KBTBD6 mRNA

NCBI chr15:61,257,360...61,259,117

G

potassium voltage-gated channel subfamily A member 5

decreases expression

ISO

Zinc deficiency results in decreased expression of KCNA5 mRNA

NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408

G

potassium voltage-gated channel subfamily D member 2

increases expression

EXP

Zinc deficiency results in increased expression of KCND2 mRNA; Zinc results in increased expression of KCND2 mRNA

PMID:12672911 PMID:15159208

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium voltage-gated channel modifier subfamily G member 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KCNG3 mRNA

NCBI chr 6:16,803,842...16,851,791
Ensembl chr 6:16,803,665...16,851,791

G

potassium inwardly-rectifying channel, subfamily J, member 5

increases expression

EXP

Zinc results in increased expression of KCNJ5 mRNA

NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101

G

potassium inwardly-rectifying channel, subfamily J, member 8

increases expression

EXP

Zinc results in increased expression of KCNJ8 mRNA

NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:177,239,908...177,246,531

G

potassium voltage-gated channel subfamily Q member 1

increases expression

EXP

Zinc results in increased expression of KCNQ1 mRNA

PMID:15159208 PMID:17074742

NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:207,721,131...208,054,072

G

potassium channel tetramerization domain containing 5

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of KCTD5 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of KCTD5 mRNA

PMID:18593933 PMID:22171008

NCBI chr10:13,583,781...13,609,762
Ensembl chr10:13,583,781...13,610,062

G

lysine demethylase 2A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KDM2A mRNA

NCBI chr 1:211,041,859...211,125,749
Ensembl chr 1:211,041,885...211,084,479

G

lysine demethylase 4B

increases expression

ISO

Zinc deficiency results in increased expression of KDM4B mRNA

NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,245,899...1,324,384

G

lysine demethylase 4C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KDM4C mRNA

NCBI chr 5:93,146,404...93,353,040
Ensembl chr 5:93,146,969...93,353,040

G

lysine demethylase 6B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KDM6B mRNA

NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,619,544...54,629,610

G

lysine demethylase 7A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KDM7A mRNA

NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:68,871,677...68,931,506

G

kinase insert domain receptor

decreases expression

EXP

Zinc results in decreased expression of KDR mRNA

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

Kelch-like ECH-associated protein 1

multiple interactions
affects binding

ISO

4,4'-dipyridyl disulfide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]; 4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]; Hydrogen Peroxide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]; sulforaphane promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]; Zinc inhibits the reaction [Cobalt binds to KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

alpha-ketoglutarate dehydrogenase subunit 4

decreases expression

ISO

Zinc deficiency results in decreased expression of KGD4 mRNA

NCBI chr 2:33,604,611...33,614,988
Ensembl chr 2:33,604,613...33,615,095

G

kinesin family member 1B

increases expression

ISO

Zinc deficiency results in increased expression of KIF1B mRNA

NCBI chr 5:164,890,778...165,025,848
Ensembl chr 5:164,894,763...165,008,841

G

kinesin family member 20A

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of KIF20A mRNA
Zinc deficiency results in increased expression of KIF20A mRNA

PMID:16979875 PMID:22171008

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 2C

increases expression

ISO

Zinc deficiency results in increased expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1

decreases expression

ISO

Zinc deficiency results in decreased expression of KIR3DL1 mRNA

NCBI chr 1:78,756,035...78,796,961
Ensembl chr 1:78,757,394...78,796,715

G

KIT ligand

decreases expression

ISO

Zinc results in decreased expression of KITLG mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

Klotho

decreases expression

ISO

Zinc deficiency results in decreased expression of KL mRNA

NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015

G

KLF transcription factor 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

KLF transcription factor 11

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF11 mRNA

NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:47,014,326...47,037,044

G

KLF transcription factor 12

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of KLF12 mRNA

NCBI chr15:83,037,548...83,469,998
Ensembl chr15:83,045,463...83,670,640

G

KLF transcription factor 13

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF13 mRNA

NCBI chr 1:126,917,671...126,948,436
Ensembl chr 1:126,916,781...126,961,056

G

KLF transcription factor 15

increases expression

EXP

Zinc results in increased expression of KLF15 mRNA

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373

G

KLF transcription factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768

G

KLF transcription factor 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF3 mRNA

NCBI chr14:43,828,387...43,859,418
Ensembl chr14:43,828,387...43,850,826

G

KLF transcription factor 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

KLF transcription factor 6

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLF6 mRNA
Zinc deficiency results in increased expression of KLF6 mRNA

PMID:18356318 PMID:18593933

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601

G

KLF transcription factor 9

increases expression
decreases expression

EXP
ISO

Zinc results in increased expression of KLF9 mRNA
Zinc deficiency results in decreased expression of KLF9 mRNA

PMID:17074742 PMID:20857495

NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641

G

kelch-like family member 18

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLHL18 mRNA

NCBI chr 8:119,279,081...119,337,850
Ensembl chr 8:119,279,081...119,337,719

G

kelch-like family member 21

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLHL21 mRNA

NCBI chr 5:167,797,621...167,806,276
Ensembl chr 5:167,797,591...167,806,276

G

kelch-like family member 24

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

kelch-like family member 25

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KLHL25 mRNA

NCBI chr 1:139,134,655...139,159,898
Ensembl chr 1:139,122,977...139,165,970

G

kelch-like family member 41

decreases expression

EXP

Zinc deficiency results in decreased expression of KLHL41 mRNA

NCBI chr 3:74,842,118...74,855,244

G

kelch-like family, member 42

decreases expression

ISO

Zinc deficiency results in decreased expression of KLHL42 mRNA

NCBI chr 4:181,730,343...181,760,899
Ensembl chr 4:181,735,244...181,757,013

G

kallikrein related-peptidase 10

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of KLK10 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of KLK10 mRNA]

NCBI chr 1:103,371,638...103,375,918
Ensembl chr 1:103,371,638...103,375,918

G

kallikrein 1-related peptidase C10

multiple interactions

ISO

Zinc affects the reaction [SEMG2 protein binds to KLK3 protein]

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

kallikrein related-peptidase 5

multiple interactions
decreases activity

ISO

SEMG1 protein inhibits the reaction [Zinc results in decreased activity of KLK5 protein]; SEMG2 protein inhibits the reaction [Zinc results in decreased activity of KLK5 protein]

NCBI chr 1:103,432,743...103,442,011
Ensembl chr 1:103,433,065...103,441,305

G

kallikrein related-peptidase 8

decreases activity

ISO

Zinc results in decreased activity of KLK8 protein

NCBI chr 1:103,388,352...103,395,195
Ensembl chr 1:103,388,352...103,395,195

G

kallikrein B1

affects binding

ISO

KLKB1 protein binds to Zinc

NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339

G

killer cell lectin like receptor B1A

affects expression

ISO

Zinc affects the expression of KLRB1 mRNA

NCBI chr 4:163,576,672...163,590,201
Ensembl chr 4:163,576,672...163,619,374

G

killer cell lectin like receptor D1

decreases expression

ISO

Zinc deficiency results in decreased expression of KLRD1 mRNA

NCBI chr 4:164,730,833...164,742,539
Ensembl chr 4:164,730,856...164,742,538

G

kininogen 1

affects binding

ISO

KNG1 protein binds to Zinc

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148

G

karyopherin subunit alpha 2

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of KPNA2 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of KPNA2 mRNA]

NCBI chr10:92,433,678...92,445,841
Ensembl chr10:92,433,679...92,445,937

G

karyopherin subunit alpha 5

decreases expression

ISO

Zinc deficiency results in decreased expression of KPNA5 mRNA

NCBI chr20:31,365,647...31,430,793
Ensembl chr20:31,365,656...31,430,792

G

lysine-rich coiled-coil 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of KRCC1 mRNA

NCBI chr 4:104,819,958...104,832,987
Ensembl chr 4:104,819,190...104,855,484

G

keratin 1

multiple interactions
affects binding

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT1 mRNA
KRT1 protein binds to Zinc

PMID:12517797 PMID:23896426

NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537

G

keratin 10

affects binding

ISO

KRT10 protein binds to Zinc

NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,834,840...84,839,160

G

keratin 14

multiple interactions
affects binding
increases expression

ISO
EXP

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT14 protein; TRP53 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of KRT14 protein]
KRT14 protein binds to Zinc
Zinc inhibits the reaction [Zinc deficiency results in increased expression of KRT14 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of KRT14 protein]
Zinc deficiency results in increased expression of KRT14 mRNA; Zinc deficiency results in increased expression of KRT14 protein

PMID:12517797 PMID:16140947 PMID:23896426

NCBI chr10:85,638,182...85,642,450

G

keratin 16

affects binding

ISO

KRT16 protein binds to Zinc

NCBI chr10:85,669,276...85,672,211
Ensembl chr10:85,669,276...85,672,211

G

keratin 19

increases expression

ISO

Zinc deficiency results in increased expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

keratin 2

affects binding

ISO

KRT2 protein binds to Zinc

NCBI chr 7:134,819,584...134,826,736
Ensembl chr 7:134,819,584...134,827,011

G

keratin 4

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of KRT4 mRNA

NCBI chr 7:134,924,753...134,931,050
Ensembl chr 7:134,924,753...134,930,713

G

keratin 5

affects binding

ISO

KRT5 protein binds to Zinc

NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569

G

keratin 8

increases expression

ISO

Zinc deficiency results in increased expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

keratin 9

affects binding

ISO

KRT9 protein binds to Zinc

NCBI chr10:85,621,360...85,627,626
Ensembl chr10:85,621,360...85,627,626

G

keratin associated protein 9-1, pseudogene 1

decreases expression

ISO

Zinc deficiency results in decreased expression of KRTAP9-9 mRNA

NCBI chr10:85,306,914...85,307,471

G

kinase suppressor of ras 1

increases phosphorylation

ISO

Zinc results in increased phosphorylation of KSR1 protein

NCBI chr10:64,459,786...64,596,083
Ensembl chr10:64,459,786...64,596,082

G

L-2-hydroxyglutarate dehydrogenase

increases expression

ISO

Zinc deficiency results in increased expression of L2HGDH mRNA

NCBI chr 6:93,900,427...93,941,534
Ensembl chr 6:93,900,427...93,941,534

G

laminin subunit alpha 4

increases expression

ISO

Zinc deficiency results in increased expression of LAMA4 mRNA

NCBI chr20:43,946,898...44,087,972
Ensembl chr20:43,946,898...44,087,972

G

laminin subunit alpha 5

increases expression

ISO

Zinc deficiency results in increased expression of LAMA5 mRNA

NCBI chr 3:187,647,904...187,695,974
Ensembl chr 3:187,647,904...187,696,173

G

laminin subunit beta 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LAMB1 mRNA

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760

G

La ribonucleoprotein 1B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LARP1B mRNA

NCBI chr 2:125,860,935...125,897,189
Ensembl chr 2:125,863,997...125,897,189

G

La ribonucleoprotein 4B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LARP4B mRNA

NCBI chr17:65,813,125...65,908,920
Ensembl chr17:65,830,022...65,908,676

G

large tumor suppressor kinase 1

multiple interactions

ISO

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to LATS1 protein]; Zinc binds to and affects the folding of LATS1 protein

NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029

G

large tumor suppressor kinase 2

multiple interactions
affects binding

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LATS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to LATS2 protein]

PMID:18593933 PMID:35027733

NCBI chr15:35,940,632...35,992,225
Ensembl chr15:35,940,632...35,980,842

G

lipopolysaccharide binding protein

affects binding

ISO

LBP protein binds to Zinc

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518

G

lecithin cholesterol acyltransferase

affects expression

EXP

Zinc affects the expression of LCAT mRNA

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081

G

LCK proto-oncogene, Src family tyrosine kinase

increases expression

ISO

Zinc deficiency results in increased expression of LCK mRNA; Zinc deficiency results in increased expression of LCK protein

NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267

G

low density lipoprotein receptor

multiple interactions
increases response to substance

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LDLR mRNA
[LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of PPARG mRNA; [LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 mRNA; [LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 protein

PMID:16140885 PMID:18593933

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

LEM domain containing 3

decreases expression

ISO

Zinc deficiency results in decreased expression of LEMD3 mRNA

NCBI chr 7:58,300,556...58,389,485
Ensembl chr 7:58,316,851...58,384,707

G

leukocyte receptor cluster member 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LENG8 mRNA

NCBI chr 1:79,113,038...79,124,868
Ensembl chr 1:79,113,038...79,124,738

G

leptin

decreases abundance
decreases expression
multiple interactions
increases expression

ISO
EXP

LEP gene mutant form results in decreased abundance of Zinc
Zinc deficiency results in decreased expression of LEP protein
[Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein
Zinc deficiency results in increased expression of LEP protein
Zinc results in decreased expression of LEP mRNA
IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]

PMID:10965932 PMID:18316168 PMID:20660286 PMID:24155903 PMID:25088245

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

leptin receptor

multiple interactions

EXP
ISO

[LEPR gene mutant form results in increased susceptibility to Ethanol] which results in decreased abundance of Zinc
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA; [Zinc deficiency co-treated with Ethanol] results in increased expression of LEPR mRNA

PMID:15475485 PMID:24155903 PMID:33549593

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

leptin receptor overlapping transcript-like 1

decreases expression

ISO

Zinc deficiency results in decreased expression of LEPROTL1 mRNA

NCBI chr16:64,744,148...64,756,776
Ensembl chr16:64,743,717...64,756,776

G

galectin 2

decreases expression

ISO

Zinc deficiency results in decreased expression of LGALS2 mRNA

NCBI chr 7:112,283,630...112,290,228
Ensembl chr 7:112,282,822...112,285,392

G

luteinizing hormone subunit beta

decreases expression

EXP

Zinc deficiency results in decreased expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIM homeobox 2

decreases expression

ISO

Zinc deficiency results in decreased expression of LHX2 mRNA

NCBI chr 3:42,523,345...42,553,646
Ensembl chr 3:42,535,744...42,553,645

G

LIF, interleukin 6 family cytokine

multiple interactions
decreases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LIF mRNA
Zinc deficiency results in decreased expression of LIF mRNA

PMID:16979875 PMID:18356318

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

DNA ligase 3

multiple interactions
affects binding

ISO

sodium arsenite inhibits the reaction [Zinc binds to LIG3 protein]

NCBI chr10:68,215,371...68,238,705
Ensembl chr10:68,215,407...68,238,704

G

lipase C, hepatic type

affects expression
multiple interactions

ISO

Zinc deficiency affects the expression of LIPC mRNA
[Zinc deficiency co-treated with Ethanol] results in decreased expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lipase F, gastric type

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of LIPF mRNA
Zinc affects the reaction [Zinc deficiency results in decreased expression of LIPF mRNA]

NCBI chr 1:240,906,706...240,925,053
Ensembl chr 1:240,906,706...240,925,053

G

LIM domain only 2

increases expression

ISO

Zinc results in increased expression of LMO2 mRNA

NCBI chr 3:110,810,162...110,832,895
Ensembl chr 3:110,809,912...110,833,075

G

LIM domain only 4

increases expression

ISO

Zinc deficiency results in increased expression of LMO4 mRNA

NCBI chr 2:235,924,574...235,941,609
Ensembl chr 2:235,924,403...235,941,275

G

LIM domain 7

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of LMO7 mRNA

NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551

G

uncharacterized LOC130046242

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF57 mRNA

NCBI chr 7:8,663,437...8,669,068
Ensembl chr 7:8,663,217...8,667,271

G

lipoprotein lipase

affects expression
decreases expression

EXP
ISO

Zinc affects the expression of LPL mRNA
Zinc deficiency results in decreased expression of LPL mRNA

PMID:17181878 PMID:20857495

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LRAT domain containing 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRATD1 mRNA

NCBI chr 6:42,646,515...42,650,988
Ensembl chr 6:42,640,190...42,651,204

G

ligand dependent nuclear receptor interacting factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LRIF1 mRNA

NCBI chr 2:196,919,606...197,010,713
Ensembl chr 2:196,919,151...197,010,717

G

leucine rich repeat containing 24

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRRC24 mRNA

NCBI chr 7:110,317,935...110,325,201
Ensembl chr 7:110,317,020...110,325,074

G

leucine rich repeat containing 8 VRAC subunit A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LRRC8A mRNA

NCBI chr 3:33,902,299...33,934,989
Ensembl chr 3:33,908,268...33,933,625

G

leucine rich repeat containing 8 VRAC subunit C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LRRC8C mRNA

NCBI chr14:4,528,721...4,621,259
Ensembl chr14:4,531,823...4,620,049

G

leucine rich repeat neuronal 3

decreases expression

ISO

Zinc deficiency results in decreased expression of LRRN3 mRNA

NCBI chr 6:64,216,164...64,247,293
Ensembl chr 6:64,215,878...64,247,614

G

leukotriene A4 hydrolase

multiple interactions

ISO

[Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of LTA4H protein

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:29,856,802...29,888,641

G

latent transforming growth factor beta binding protein 2

decreases expression

ISO

Zinc deficiency results in decreased expression of LTBP2 mRNA

NCBI chr 6:110,161,029...110,261,586
Ensembl chr 6:110,161,029...110,257,298

G

LUC7 pre-mRNA splicing factor like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of LUC7L mRNA

NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,777,829...15,817,940

G

lymphocyte antigen 96

affects expression

ISO

Zinc affects the expression of LY96 mRNA

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816

G

lysophospholipase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of LYPLA1 mRNA

PMID:12672911 PMID:15671213

NCBI chr 5:19,477,408...19,506,568
Ensembl chr 5:19,477,409...19,506,522

G

LYR motif containing 4

decreases expression

ISO

Zinc deficiency results in decreased expression of LYRM4 mRNA

NCBI chr17:28,951,912...29,067,300
Ensembl chr17:28,951,924...29,143,177

G

MAD2L1 binding protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAD2L1BP mRNA

NCBI chr 9:22,329,699...22,334,024
Ensembl chr 9:22,329,698...22,335,016

G

MAF bZIP transcription factor B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAFB mRNA

NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975

G

MAF bZIP transcription factor F

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAF bZIP transcription factor G

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

MAF bZIP transcription factor K

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

mago homolog B, exon junction complex subunit

increases expression

ISO

Zinc deficiency results in increased expression of MAGOHB mRNA

NCBI chr 4:166,765,558...166,773,406
Ensembl chr 4:166,765,618...166,773,851

G

magnesium transporter 1

increases expression

ISO

Zinc deficiency results in increased expression of MAGT1 mRNA

NCBI chr X:75,104,040...75,145,247
Ensembl chr X:75,106,172...75,145,365

G

mal, T-cell differentiation protein

increases expression

ISO

Zinc results in increased expression of MAL mRNA

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

mastermind-like transcriptional coactivator 1

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of MAML1 mRNA

NCBI chr10:35,089,715...35,124,100
Ensembl chr10:35,089,715...35,124,100

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of MAP1LC3B mRNA
[Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in increased expression of MAP1LC3B protein]

PMID:18593933 PMID:32233808

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO
EXP

Zinc inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of MAP2K1 protein]
Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of MAP2K1 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

multiple interactions

ISO
EXP

Zinc inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of MAP2K2 protein]
Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of MAP2K2 protein]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen-activated protein kinase kinase kinase 1

decreases expression

EXP

Zinc results in decreased expression of MAP3K1 mRNA

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen activated protein kinase kinase kinase 12

increases expression

ISO

Zinc results in increased expression of MAP3K12 mRNA

NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:135,508,790...135,515,137

G

mitogen-activated protein kinase kinase kinase 14

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAP3K14 mRNA

NCBI chr10:88,665,417...88,715,669
Ensembl chr10:88,665,417...88,715,592

G

microtubule-associated protein 4

increases expression

ISO

Zinc deficiency results in increased expression of MAP4 mRNA

NCBI chr 8:118,800,393...118,942,805
Ensembl chr 8:118,804,022...118,942,805

G

mitogen activated protein kinase kinase kinase kinase 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MAP4K1 mRNA

NCBI chr 1:93,398,460...93,419,996
Ensembl chr 1:93,398,454...93,419,993

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; [bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK1 protein; bisindolylmaleimide I inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; TP53 protein inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; YM-254890 inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of MAPK1 protein]
[[Taurine binds to Zinc] which co-treated with poly(N-vinylpyrrolidine)] results in decreased expression of MAPK1 protein modified form; N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Zinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of MAPK1 protein]; Zinc results in increased phosphorylation of and results in increased activity of MAPK1 protein
[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK1 protein; [Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK1 protein; Zinc promotes the reaction [OPRM1 protein binds to MAPK1 protein]
Zinc results in decreased phosphorylation of MAPK1 protein
Zinc deficiency results in decreased phosphorylation of MAPK1 protein

PMID:11331359 PMID:12915106 PMID:15880691 PMID:16373669 PMID:16606632 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen-activated protein kinase 12

increases expression

ISO

Zinc deficiency results in increased expression of MAPK12 mRNA

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
decreases phosphorylation

EXP
ISO

N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Zinc inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Zinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of MAPK3 protein]; Zinc results in increased phosphorylation of and results in increased activity of MAPK3 protein
[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPK3 protein; [Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK3 protein; Zinc promotes the reaction [OPRM1 protein binds to MAPK3 protein]
Zinc results in decreased phosphorylation of MAPK3 protein
Zinc deficiency results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; [bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK3 protein; bisindolylmaleimide I inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; TP53 protein inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; YM-254890 inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Zinc inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of MAPK3 protein]

PMID:12915106 PMID:15880691 PMID:16373669 PMID:16606632 PMID:16648635 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

ISO
EXP

Zinc results in increased phosphorylation of MAPK8 protein
[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]
[[Taurine binds to Zinc] which co-treated with poly(N-vinylpyrrolidine)] results in decreased expression of MAPK8 protein modified form; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased expression of MAPK8 mRNA]; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; [Taurine binds to Zinc] which results in decreased expression of MAPK8 mRNA
[Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK8 protein

PMID:16606632 PMID:16648635 PMID:26335259 PMID:27501764 PMID:30768131

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

EXP

[[Taurine binds to Zinc] which co-treated with poly(N-vinylpyrrolidine)] results in decreased expression of MAPK9 protein modified form; [Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein]

PMID:26335259 PMID:27501764

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microtubule-associated protein, RP/EB family, member 1

increases expression

EXP

Zinc deficiency results in increased expression of MAPRE1 mRNA

NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:162,673,195...162,711,210

G

microtubule-associated protein tau

multiple interactions

EXP

[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein; GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

membrane associated ring-CH-type finger 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MARCHF6 mRNA

NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792

G

myristoylated alanine rich protein kinase C substrate

decreases expression

ISO

Zinc deficiency results in decreased expression of MARCKS mRNA

NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882

G

microtubule affinity regulating kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MARK3 mRNA

NCBI chr 6:136,447,327...136,537,409
Ensembl chr 6:136,448,531...136,537,404

G

MBL associated serine protease 1

increases expression

ISO

Zinc deficiency results in increased expression of MASP1 mRNA

NCBI chr11:90,839,081...90,909,922
Ensembl chr11:90,839,061...90,917,470

G

methionine adenosyltransferase 2A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MAT2A mRNA

NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645

G

MYC associated factor X

increases expression

EXP

Zinc deficiency results in increased expression of MAX mRNA

NCBI chr 6:101,369,989...101,395,333
Ensembl chr 6:101,369,988...101,395,549

G

methyl-CpG binding domain protein 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MBD6 mRNA

NCBI chr 7:64,992,877...65,001,274
Ensembl chr 7:64,992,877...64,998,589

G

mannose binding lectin 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546

G

membrane bound O-acyltransferase domain containing 7

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MBOAT7 mRNA

NCBI chr 1:74,440,618...74,454,896
Ensembl chr 1:74,439,660...74,454,894

G

myelin basic protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MBP mRNA

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

mbt domain containing 1

increases expression

ISO

Zinc deficiency results in increased expression of MBTD1 mRNA

NCBI chr10:79,336,041...79,392,315
Ensembl chr10:79,335,235...79,392,315

G

membrane-bound transcription factor peptidase, site 1

increases expression

ISO

Zinc deficiency results in increased expression of MBTPS1 mRNA

NCBI chr19:64,470,245...64,521,438
Ensembl chr19:64,470,545...64,521,342

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
increases expression
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MCL1 mRNA
Zinc results in increased expression of MCL1 mRNA
Zinc deficiency results in decreased expression of MCL1 mRNA

PMID:11739864 PMID:12107073 PMID:18356318 PMID:18593933

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

minichromosome maintenance complex component 2

increases expression

ISO

Zinc deficiency results in increased expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094

G

minichromosome maintenance complex component 4

increases expression

ISO

Zinc deficiency results in increased expression of MCM4 mRNA

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:98,762,634...98,776,536

G

minichromosome maintenance complex component 5

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,488,813...13,517,758

G

minichromosome maintenance complex component 6

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467

G

mucolipin TRP cation channel 1

affects abundance

ISO

MCOLN1 protein affects the abundance of Zinc

NCBI chr12:6,357,851...6,372,151
Ensembl chr12:6,357,807...6,372,151

G

mast cell protease 8

decreases expression

EXP

Zinc deficiency results in decreased expression of MCPT8 mRNA

NCBI chr15:33,769,575...33,772,633

G

MDM2 proto-oncogene

multiple interactions
increases ubiquitination
affects expression

ISO

Zinc binds to and results in increased folding of MDM2 protein; Zinc promotes the reaction [MDM2 protein binds to MDM2 protein]; Zinc promotes the reaction [MDM2 protein binds to MDM4 protein]
Zinc results in increased ubiquitination of MDM2 protein
Zinc affects the expression of MDM2 protein

PMID:16636310 PMID:16965791

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MDM4 regulator of p53

multiple interactions

ISO

Zinc promotes the reaction [MDM2 protein binds to MDM4 protein]

NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372

G

mediator complex subunit 13L

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of MED13L mRNA

NCBI chr12:43,468,556...43,665,819
Ensembl chr12:43,468,556...43,665,819

G

mediator complex subunit 17

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MED17 mRNA

NCBI chr 8:20,382,995...20,401,993
Ensembl chr 8:20,382,995...20,401,993

G

mediator complex subunit 26

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MED26 mRNA

NCBI chr16:17,333,770...17,384,797
Ensembl chr16:17,327,734...17,383,603

G

mediator complex subunit 29

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MED29 mRNA

NCBI chr 1:92,805,505...92,810,908

G

mediator complex subunit 30

decreases expression

ISO

Zinc deficiency results in decreased expression of MED30 mRNA

NCBI chr 7:85,894,638...85,916,373
Ensembl chr 7:85,894,605...85,917,973

G

mediator complex subunit 4

decreases expression

ISO

Zinc deficiency results in decreased expression of MED4 mRNA

NCBI chr15:55,106,079...55,116,354
Ensembl chr15:55,105,998...55,116,429

G

mediator complex subunit 9

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MED9 mRNA

NCBI chr10:45,250,229...45,264,988
Ensembl chr10:45,250,223...45,264,987

G

myocyte enhancer factor 2a

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162

G

myocyte enhancer factor 2D

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MEF2D mRNA

NCBI chr 2:175,904,332...175,933,451
Ensembl chr 2:175,903,959...175,930,760

G

mesenchyme homeobox 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MEOX2 mRNA

NCBI chr 6:59,584,025...59,644,722
Ensembl chr 6:59,583,785...59,644,700

G

meteorin-like, glial cell differentiation regulator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of METRNL mRNA

NCBI chr10:107,462,148...107,476,143
Ensembl chr10:107,462,109...107,476,135

G

methyltransferase 4, N6-adenosine

decreases expression

ISO

Zinc deficiency results in decreased expression of METTL4 mRNA

NCBI chr 9:118,887,740...118,967,433
Ensembl chr 9:118,887,528...118,911,364

G

microfibril associated protein 3 like

decreases expression

ISO

Zinc deficiency results in decreased expression of MFAP3L mRNA

NCBI chr16:34,422,490...34,465,544
Ensembl chr16:34,426,696...34,441,709

G

mitochondrial fission factor

decreases expression

ISO

Zinc deficiency results in decreased expression of MFF mRNA

NCBI chr 9:91,455,931...91,484,171
Ensembl chr 9:91,455,871...91,484,171

G

mitofusin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MFN2 mRNA

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

major facilitator superfamily domain containing 4A

increases expression

ISO

Zinc deficiency results in increased expression of MFSD4A mRNA

NCBI chr13:46,015,321...46,062,633
Ensembl chr13:46,021,659...46,062,633

G

major facilitator superfamily domain containing 6

decreases expression

ISO

Zinc deficiency results in decreased expression of MFSD6 mRNA

NCBI chr 9:56,265,152...56,350,449
Ensembl chr 9:56,265,237...56,350,446

G

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

increases expression

ISO

Zinc deficiency results in increased expression of MGAT3 mRNA

NCBI chr 7:113,614,011...113,640,201
Ensembl chr 7:113,598,059...113,643,481

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

ISO

Zinc binds to and results in increased activity of and results in increased stability of MGMT protein; Zinc binds to and results in increased activity of MGMT protein

PMID:12549918 PMID:12974631

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

matrix Gla protein

multiple interactions
increases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in increased expression of MGP mRNA]

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859

G

microsomal glutathione S-transferase 1

decreases expression

EXP

Zinc deficiency results in decreased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

MIA SH3 domain ER export factor 2

increases expression

ISO

Zinc deficiency results in increased expression of MIA2 mRNA

NCBI chr 6:82,522,398...82,620,136
Ensembl chr 6:82,522,422...82,620,178

G

MIB E3 ubiquitin protein ligase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MIB1 mRNA

NCBI chr18:2,075,309...2,199,774
Ensembl chr18:2,075,309...2,193,475

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MICAL1 mRNA

NCBI chr20:46,547,983...46,568,487
Ensembl chr20:46,556,536...46,568,487

G

midline 1

affects binding

ISO

Zinc binds to MID1 protein

NCBI chr X:27,678,248...28,053,049
Ensembl chr X:27,681,867...27,906,105

G

microRNA 100

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR100 mRNA

NCBI chr 8:50,798,295...50,798,374
Ensembl chr 8:50,798,295...50,798,374

G

microRNA 101-2

increases expression

EXP

Zinc deficiency results in increased expression of MIR101B mRNA

NCBI chr 1:236,273,922...236,274,018
Ensembl chr 1:236,273,922...236,274,018

G

microRNA 107

increases expression

EXP

Zinc deficiency results in increased expression of MIR107 mRNA

NCBI chr 1:241,750,418...241,750,504

G

microRNA 10a

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR10A mRNA

NCBI chr10:81,779,709...81,779,818
Ensembl chr10:81,779,709...81,779,818

G

microRNA 10b

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of MIR10B mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of MIR10B mRNA]

NCBI chr 3:80,035,859...80,035,967
Ensembl chr 3:80,035,859...80,035,967

G

microRNA 1224

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR1224 mRNA

NCBI chr11:93,811,291...93,811,375

G

microRNA 130a

increases expression

EXP

Zinc deficiency results in increased expression of MIR130A mRNA

NCBI chr 3:90,229,228...90,229,315

G

microRNA 132

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR132 mRNA

NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,522,033...60,522,133

G

microRNA 133b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR133B mRNA

NCBI chr 9:30,594,582...30,594,665
Ensembl chr 9:30,594,582...30,594,665

G

microRNA 134

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR134 mRNA

NCBI chr 6:134,570,313...134,570,385

G

microRNA 137

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR137 mRNA

NCBI chr 2:209,165,709...209,165,810
Ensembl chr 2:209,165,712...209,165,813

G

microRNA 139

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR139 mRNA

NCBI chr 1:165,290,859...165,290,926
Ensembl chr 1:165,290,856...165,290,933

G

microRNA 142

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of MIR142 mRNA
Zinc deficiency results in decreased expression of MIR142 mRNA

NCBI chr10:73,055,104...73,055,190
Ensembl chr10:73,055,097...73,055,207

G

microRNA 145

multiple interactions
decreases expression

ISO

Zinc inhibits the reaction [Zinc deficiency results in decreased expression of MIR145 mRNA]

NCBI chr18:57,369,983...57,370,070

G

microRNA 146a

decreases expression
increases expression

ISO
EXP

Zinc deficiency results in decreased expression of MIR146A mRNA
Zinc deficiency results in increased expression of MIR146A mRNA

PMID:22171008 PMID:22689922

NCBI chr10:28,349,996...28,350,090

G

microRNA 147

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR147 mRNA

NCBI chr 3:130,176,275...130,176,353
Ensembl chr 3:130,176,275...130,176,353

G

microRNA 150

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of MIR150 mRNA
Zinc deficiency results in decreased expression of MIR150 mRNA

NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:104,741,487...104,741,571

G

microRNA 151

decreases expression
increases expression

EXP

Zinc deficiency results in decreased expression of MIR151 mRNA
Zinc deficiency results in increased expression of MIR151 mRNA

NCBI chr 7:107,061,380...107,061,476

G

microRNA 153

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR153 mRNA

NCBI chr 6:144,306,594...144,306,680
Ensembl chr 6:144,306,594...144,306,680

G

microRNA 155

decreases expression

ISO

Zinc deficiency results in decreased expression of MIR155 mRNA

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178

G

microRNA 15b

decreases expression
increases expression

ISO
EXP

Zinc deficiency results in decreased expression of MIR15B mRNA
Zinc deficiency results in increased expression of MIR15B mRNA

PMID:22171008 PMID:22689922

NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275

G

microRNA 16-2

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR16-2 mRNA

NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421

G

microRNA 181c

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR181C mRNA

NCBI chr19:40,888,291...40,888,396
Ensembl chr19:40,888,291...40,888,396

G

microRNA 182

decreases uptake
multiple interactions

ISO

MIR182 mRNA results in decreased uptake of Zinc
[MIR182 mRNA co-treated with MIR183 mRNA co-treated with MIR96 mRNA] results in decreased uptake of Zinc

NCBI chr 4:59,752,246...59,752,307

G

microRNA 183

multiple interactions

ISO

[MIR182 mRNA co-treated with MIR183 mRNA co-treated with MIR96 mRNA] results in decreased uptake of Zinc

NCBI chr 4:59,756,044...59,756,153

G

microRNA 184

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR184 mRNA

NCBI chr 8:99,222,982...99,223,058

G

microRNA 185

increases expression

EXP

Zinc deficiency results in increased expression of MIR185 mRNA

NCBI chr11:96,169,028...96,169,107
Ensembl chr11:96,169,028...96,169,107

G

microRNA 186

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR186 mRNA

NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:249,241,650...249,241,735

G

microRNA 187

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR187 mRNA

NCBI chr18:16,005,947...16,006,050

G

microRNA 18a

increases expression

EXP

Zinc deficiency results in increased expression of MIR18A mRNA

NCBI chr15:98,587,984...98,588,079
Ensembl chr15:98,587,984...98,588,079

G

microRNA 191

increases expression

EXP

Zinc deficiency results in increased expression of MIR191 mRNA

NCBI chr 8:118,142,627...118,142,717

G

microRNA 192

decreases expression

EXP
ISO

Zinc deficiency results in decreased expression of MIR192 mRNA

PMID:22171008 PMID:22689922

NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:212,994,209...212,994,318

G

microRNA 195

decreases expression

ISO

Zinc deficiency results in decreased expression of MIR195 mRNA

NCBI chr10:55,450,495...55,450,581
Ensembl chr10:55,450,495...55,450,581

G

microRNA 196b

decreases expression
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of MIR196B mRNA
[Air Pollutants, Occupational results in increased abundance of Zinc] which results in increased expression of MIR196B mRNA

PMID:22689922 PMID:27506416

NCBI chr 4:82,661,101...82,661,185

G

microRNA 19a

increases expression

EXP

Zinc deficiency results in increased expression of MIR19A mRNA

NCBI chr15:98,588,131...98,588,212
Ensembl chr15:98,588,131...98,588,212

G

microRNA 200a

decreases expression

ISO
EXP

Zinc deficiency results in decreased expression of MIR200A mRNA

PMID:22171008 PMID:22689922

NCBI chr 5:171,930,717...171,930,805

G

microRNA 200b

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of MIR200B mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of MIR200B mRNA]

NCBI chr 5:171,931,495...171,931,589

G

microRNA 200c

decreases expression

ISO

Zinc deficiency results in decreased expression of MIR200C mRNA

NCBI chr 4:159,209,965...159,210,033

G

microRNA 203

increases expression

EXP

Zinc deficiency results in increased expression of MIR203 mRNA

NCBI chr 6:137,020,691...137,020,805

G

microRNA 204

multiple interactions
decreases expression

ISO
EXP

Zinc inhibits the reaction [Zinc deficiency results in decreased expression of MIR204 mRNA]

PMID:22171008 PMID:22689922

NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570

G

microRNA 205

increases expression
decreases expression

ISO
EXP

Zinc deficiency results in increased expression of MIR205 mRNA
Zinc deficiency results in decreased expression of MIR205 mRNA

PMID:22171008 PMID:22689922

NCBI chr13:107,564,535...107,564,642

G

microRNA 206

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR206 mRNA

NCBI chr 9:30,590,697...30,590,780
Ensembl chr 9:30,590,697...30,590,780

G

microRNA 208a

decreases expression
increases expression

EXP
ISO

Zinc deficiency results in decreased expression of MIR208A mRNA
Zinc deficiency results in increased expression of MIR208A mRNA

PMID:22171008 PMID:22689922

NCBI chr15:32,395,552...32,395,634

G

microRNA 20a

increases expression

EXP

Zinc deficiency results in increased expression of MIR20A mRNA

NCBI chr15:98,588,303...98,588,387
Ensembl chr15:98,588,303...98,588,387

G

microRNA 21

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of MIR21 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of MIR21 mRNA]

NCBI chr10:71,902,600...71,902,691

G

microRNA 210

increases expression

EXP

Zinc deficiency results in increased expression of MIR210 mRNA

NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:205,755,917...205,756,034

G

microRNA 211

increases expression
decreases expression

EXP
ISO

Zinc deficiency results in increased expression of MIR211 mRNA
Zinc deficiency results in decreased expression of MIR211 mRNA

PMID:22171008 PMID:22689922

NCBI chr 1:127,189,328...127,189,433
Ensembl chr 1:127,189,328...127,189,433

G

microRNA 212

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR212 mRNA

NCBI chr10:60,521,740...60,521,850
Ensembl chr10:60,521,740...60,521,850

G

microRNA 214

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of MIR214 mRNA
Zinc deficiency results in decreased expression of MIR214 mRNA

NCBI chr13:77,121,645...77,121,752
Ensembl chr13:77,121,643...77,121,752

G

microRNA 216a

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR216A mRNA

NCBI chr14:106,725,077...106,725,182
Ensembl chr14:106,725,077...106,725,182

G

microRNA 216b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR216B mRNA

NCBI chr14:106,714,026...106,714,127
Ensembl chr14:106,714,026...106,714,127

G

microRNA 217

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR217 mRNA

NCBI chr14:106,732,485...106,732,589
Ensembl chr14:106,732,485...106,732,589

G

microRNA 221

increases expression

EXP

Zinc deficiency results in increased expression of MIR221 mRNA

NCBI chr X:6,023,182...6,023,290
Ensembl chr X:6,023,182...6,023,290

G

microRNA 223

increases expression

EXP

Zinc deficiency results in increased expression of MIR223 mRNA

NCBI chr X:65,151,383...65,151,492
Ensembl chr X:65,151,383...65,151,492

G

microRNA 25

decreases expression

ISO

Zinc deficiency results in decreased expression of MIR25 mRNA

NCBI chr12:22,156,641...22,156,724

G

microRNA 26b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR26B mRNA

NCBI chr 9:83,425,709...83,425,793
Ensembl chr 9:83,425,709...83,425,793

G

microRNA 27b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR27B mRNA

NCBI chr17:1,819,147...1,819,243

G

microRNA 296

decreases expression
multiple interactions

ISO
EXP

Zinc deficiency results in decreased expression of MIR296 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of MIR296 mRNA]

PMID:22171008 PMID:22689922

NCBI chr 3:183,470,069...183,470,146

G

microRNA 300

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR300 mRNA

NCBI chr 6:134,559,918...134,559,996
Ensembl chr 6:134,559,910...134,559,999

G

microRNA 301b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR301B mRNA

NCBI chr11:97,384,033...97,384,110
Ensembl chr11:97,384,033...97,384,110

G

microRNA 30a

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR30A mRNA

NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:33,233,941...33,234,011

G

microRNA 30e

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR30E mRNA

NCBI chr 5:139,637,450...139,637,541
Ensembl chr 5:139,637,450...139,637,541

G

microRNA 31

multiple interactions
increases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in increased expression of MIR31 mRNA]

NCBI chr 5:108,714,849...108,714,954

G

microRNA 322

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR322 mRNA

NCBI chr X:137,726,147...137,726,241

G

microRNA 323

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR323 mRNA

NCBI chr 6:134,546,944...134,547,029
Ensembl chr 6:134,546,944...134,547,029

G

microRNA 324

increases expression

EXP

Zinc deficiency results in increased expression of MIR324 mRNA

NCBI chr10:55,233,363...55,233,445
Ensembl chr10:55,233,361...55,233,449

G

microRNA 325

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR325 mRNA

NCBI chr X:74,523,514...74,523,611

G

microRNA 328

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR328 mRNA

NCBI chr19:50,094,691...50,094,774

G

microRNA 330

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR330 mRNA

NCBI chr 1:87,961,207...87,961,303
Ensembl chr 1:87,961,207...87,961,303

G

microRNA mir-335

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR335 mRNA

G

microRNA 340

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of MIR340 mRNA
Zinc deficiency results in decreased expression of MIR340 mRNA

NCBI chr10:34,894,650...34,894,747
Ensembl chr10:34,894,650...34,894,747

G

microRNA 342

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of MIR342 mRNA
Zinc deficiency results in decreased expression of MIR342 mRNA

NCBI chr 6:133,329,655...133,329,753
Ensembl chr 6:133,329,655...133,329,753

G

microRNA 34a

increases expression

EXP

Zinc deficiency results in increased expression of MIR34A mRNA

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053

G

microRNA 34b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR34B mRNA

NCBI chr 8:60,306,609...60,306,692

G

microRNA 361

increases expression

EXP

Zinc deficiency results in increased expression of MIR361 mRNA

NCBI chr X:82,438,463...82,438,532

G

microRNA 362

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR362 mRNA

NCBI chr X:17,926,485...17,926,549
Ensembl chr X:17,926,485...17,926,549

G

microRNA 365b

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR365B mRNA

NCBI chr10:65,184,217...65,184,302
Ensembl chr10:65,184,214...65,184,313

G

microRNA 369

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR369 mRNA

NCBI chr 6:134,579,459...134,579,537

G

microRNA 375

decreases expression
multiple interactions

ISO
EXP

Zinc deficiency results in decreased expression of MIR375 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of MIR375 mRNA]

PMID:22171008 PMID:22689922

NCBI chr 9:83,906,582...83,906,656

G

microRNA 378

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR378A mRNA

NCBI chr18:57,128,922...57,128,986

G

microRNA 379

increases expression

EXP

Zinc deficiency results in increased expression of MIR379 mRNA

NCBI chr 6:134,543,445...134,543,529
Ensembl chr 6:134,543,445...134,543,529

G

microRNA 380

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR380 mRNA

NCBI chr 6:134,546,235...134,546,311

G

microRNA 382

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR382 mRNA

NCBI chr 6:134,569,944...134,570,023

G

microRNA 411

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR411 mRNA

NCBI chr 6:134,544,594...134,544,669
Ensembl chr 6:134,544,589...134,544,684

G

microRNA 423

increases expression

EXP

Zinc deficiency results in increased expression of MIR423 mRNA

NCBI chr10:62,412,272...62,412,350

G

microRNA 425

increases expression

EXP

Zinc deficiency results in increased expression of MIR425 mRNA

NCBI chr 8:118,143,084...118,143,166
Ensembl chr 8:118,143,084...118,143,166

G

microRNA 431

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR431 mRNA

NCBI chr 6:134,326,449...134,326,562
Ensembl chr 6:134,326,449...134,326,562

G

microRNA 433

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR433 mRNA

NCBI chr 6:134,327,358...134,327,450
Ensembl chr 6:134,327,351...134,327,456

G

microRNA 451a

increases expression

EXP

Zinc deficiency results in increased expression of MIR451A mRNA

NCBI chr10:63,459,569...63,459,640
Ensembl chr10:63,459,569...63,459,640

G

microRNA 488

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR488 mRNA

NCBI chr13:73,216,541...73,216,619
Ensembl chr13:73,216,541...73,216,619

G

microRNA 495

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR495 mRNA

NCBI chr 6:134,554,055...134,554,134
Ensembl chr 6:134,554,055...134,554,134

G

microRNA 496

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR496 mRNA

NCBI chr 6:134,575,049...134,575,127
Ensembl chr 6:134,575,049...134,575,127

G

microRNA 500

decreases expression
increases expression

EXP

Zinc deficiency results in decreased expression of MIR500 mRNA
Zinc deficiency results in increased expression of MIR500 mRNA

NCBI chr X:17,930,647...17,930,726
Ensembl chr X:17,930,637...17,930,728

G

microRNA 501

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR501 mRNA

NCBI chr X:17,927,189...17,927,272

G

microRNA 511

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR511 mRNA

NCBI chr17:82,187,953...82,188,031
Ensembl chr17:82,187,953...82,188,031

G

microRNA 532

increases expression

EXP

Zinc deficiency results in increased expression of MIR532 mRNA

NCBI chr X:17,919,185...17,919,263
Ensembl chr X:17,919,185...17,919,263

G

microRNA 539

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR539 mRNA

NCBI chr 6:134,563,598...134,563,673

G

microRNA 540

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR540 mRNA

NCBI chr 6:134,321,424...134,321,507
Ensembl chr 6:134,321,424...134,321,507

G

microRNA 541

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR541 mRNA

NCBI chr 6:134,578,421...134,578,510
Ensembl chr 6:134,578,421...134,578,510

G

microRNA 542

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR542 mRNA

NCBI chr X:137,722,176...137,722,254

G

microRNA 544

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of MIR544 mRNA
Zinc deficiency results in decreased expression of MIR544 mRNA

NCBI chr 6:134,564,935...134,565,012
Ensembl chr 6:134,564,935...134,565,012

G

microRNA 582

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR582 mRNA

NCBI chr 2:42,661,954...42,662,034
Ensembl chr 2:42,661,954...42,662,034

G

microRNA 668

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR668 mRNA

NCBI chr 6:134,570,907...134,570,974

G

microRNA 671

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR671 mRNA

NCBI chr 4:11,473,194...11,473,274

G

microRNA 759

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR759 mRNA

NCBI chr15:61,551,073...61,551,169
Ensembl chr15:61,551,073...61,551,169

G

microRNA 761

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR761 mRNA

NCBI chr 5:129,005,205...129,005,280
Ensembl chr 5:129,005,205...129,005,280

G

microRNA 770

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR770 mRNA

NCBI chr 6:134,298,084...134,298,159
Ensembl chr 6:134,298,076...134,298,169

G

microRNA 873

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR873 mRNA

NCBI chr 5:56,153,104...56,153,180

G

microRNA 874

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR874 mRNA

NCBI chr17:6,626,032...6,626,107
Ensembl chr17:6,626,032...6,626,107

G

microRNA 93

increases expression

EXP

Zinc deficiency results in increased expression of MIR93 mRNA

NCBI chr12:22,156,844...22,156,930

G

microRNA 96

multiple interactions
decreases uptake

ISO

[MIR182 mRNA co-treated with MIR183 mRNA co-treated with MIR96 mRNA] results in decreased uptake of Zinc
MIR96 mRNA results in decreased uptake of Zinc

NCBI chr 4:59,755,841...59,755,946

G

microRNA 98

increases expression

EXP

Zinc deficiency results in increased expression of MIR98 mRNA

NCBI chr X:24,460,648...24,460,755
Ensembl chr X:24,460,648...24,460,755

G

microRNA 99a

decreases expression

EXP

Zinc deficiency results in decreased expression of MIR99A mRNA

NCBI chr11:29,687,392...29,687,472
Ensembl chr11:29,687,392...29,687,472

G

microRNA 99b

increases expression

EXP

Zinc deficiency results in increased expression of MIR99B mRNA

NCBI chr 1:67,350,064...67,350,133
Ensembl chr 1:67,350,060...67,350,139

G

MIS12 kinetochore complex component

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of MIS12 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of MIS12 mRNA

PMID:18593933 PMID:22171008

NCBI chr10:56,238,317...56,246,491
Ensembl chr10:56,238,181...56,253,800

G

melanocyte inducing transcription factor

decreases expression

EXP

Zinc deficiency results in decreased expression of MITF protein

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790

G

marker of proliferation Ki-67

multiple interactions

EXP
ISO

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MKI67 mRNA

PMID:23859036 PMID:33549593

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

MKKS centrosomal shuttling protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MKKS mRNA

NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:144,654,566...144,672,831

G

muskelin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MKLN1 mRNA

NCBI chr 4:60,939,239...61,095,214
Ensembl chr 4:60,937,817...61,095,210

G

malectin

increases expression

ISO

Zinc deficiency results in increased expression of MLEC mRNA

NCBI chr12:47,118,918...47,133,598
Ensembl chr12:47,118,855...47,130,064

G

MLLT11, transcription factor 7 cofactor

decreases expression

ISO

Zinc deficiency results in decreased expression of MLLT11 mRNA

NCBI chr 2:185,484,791...185,493,961
Ensembl chr 2:185,484,793...185,493,961

G

matrix metallopeptidase 13

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 19

decreases expression

ISO

Zinc results in decreased expression of MMP19 mRNA

PMID:18316168 PMID:19071009

NCBI chr 7:1,805,732...1,814,054
Ensembl chr 7:1,805,860...1,814,863

G

matrix metallopeptidase 2

decreases activity

ISO

Zinc deficiency results in decreased activity of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 3

increases secretion
multiple interactions

ISO

Zinc results in increased secretion of MMP3 protein
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]

PMID:12972402 PMID:23503329

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 8

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MMP8 mRNA

NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729

G

matrix metallopeptidase 9

affects binding
multiple interactions
decreases expression

ISO
EXP

Zinc binds to MMP9 protein
[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP9 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP9 mRNA]
[Zinc binds to Curcumin] inhibits the reaction [Acetic Acid results in increased expression of MMP9 mRNA]
Zinc results in decreased expression of MMP9 mRNA
Zinc inhibits the reaction [TNF protein results in increased secretion of MMP9 protein]

PMID:16606632 PMID:17137715 PMID:18316168 PMID:23503329 PMID:23933360

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MN1 proto-oncogene, transcriptional regulator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MN1 mRNA

NCBI chr12:50,841,632...50,880,795
Ensembl chr12:50,841,632...50,880,795

G

MAX network transcriptional repressor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MNT mRNA

NCBI chr10:60,197,654...60,213,221
Ensembl chr10:60,197,948...60,213,209

G

MOB kinase activator 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MOB2 mRNA

NCBI chr 1:206,522,523...206,579,502
Ensembl chr 1:206,522,523...206,579,449

G

MOB family member 4, phocein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MOB4 mRNA

NCBI chr 9:64,111,170...64,135,740
Ensembl chr 9:64,111,718...64,135,779

G

molybdenum cofactor synthesis 2

decreases expression

ISO

Zinc deficiency results in decreased expression of MOCS2 mRNA

NCBI chr 2:48,237,655...48,249,394
Ensembl chr 2:48,237,655...48,249,394

G

monooxygenase, DBH-like 1

decreases expression

EXP

Zinc deficiency results in decreased expression of MOXD1 mRNA

NCBI chr 1:22,894,543...22,984,599
Ensembl chr 1:22,894,543...22,984,223

G

myeloperoxidase

multiple interactions
increases activity

EXP

Zinc inhibits the reaction [Indomethacin results in increased activity of MPO protein]
Zinc deficiency results in increased activity of MPO protein

PMID:10938463 PMID:12566098

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mercaptopyruvate sulfurtransferase

decreases expression

EXP

Zinc results in decreased expression of MPST mRNA

NCBI chr 7:111,836,079...111,843,651
Ensembl chr 7:111,835,587...111,843,650

G

muscle RAS oncogene homolog

increases expression

ISO

Zinc results in increased expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911

G

MRE11 homolog, double strand break repair nuclease

decreases expression

ISO

Zinc deficiency results in decreased expression of MRE11 mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904

G

mitochondrial ribosomal protein L18

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MRPL18 mRNA

NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:50,384,367...50,389,763

G

mitochondrial ribosomal protein S17

decreases expression

ISO

Zinc deficiency results in decreased expression of MRPS17 mRNA

NCBI chr12:32,584,635...32,587,934
Ensembl chr12:32,584,635...32,587,812

G

mitochondrial ribosomal protein S6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MRPS6 mRNA

NCBI chr11:44,778,667...44,834,420
Ensembl chr11:44,781,554...44,834,962

G

membrane spanning 4-domains A1

decreases expression

ISO

Zinc deficiency results in decreased expression of MS4A1 mRNA

NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:217,331,274...217,343,447

G

mesothelin

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MSLN mRNA

NCBI chr10:15,276,489...15,285,921
Ensembl chr10:15,275,659...15,282,153

G

msh homeobox 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MSX1 mRNA

NCBI chr14:77,185,802...77,189,735
Ensembl chr14:77,185,802...77,189,735

G

metallothionein 1, pseudogene 3

increases expression

ISO

Zinc results in increased expression of MT1E mRNA

PMID:11168427 PMID:15226459 PMID:16870260 PMID:17590860

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

affects expression
multiple interactions
decreases expression
increases abundance
decreases response to substance
affects binding
increases expression

EXP
ISO

Zinc affects the expression of MT1 mRNA; Zinc affects the expression of MT1A mRNA
[ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; [MT1 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased abundance of Zinc; [MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; [MT1 protein co-treated with MT2 protein] promotes the reaction [SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; [Zinc binds to MTF1 protein] affects the reaction [MTF1 protein binds to MT1 promoter]; [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA; cerous chloride promotes the reaction [Zinc binds to MT1 protein]; chromium hexavalent ion inhibits the reaction [trichostatin A promotes the reaction [Zinc results in increased expression of MT1 mRNA]]; chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]; Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc]; EP300 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]; EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc]; MT1 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; MT1 protein affects the reaction [Zinc results in increased expression of CSF1 mRNA]; MTF1 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]; MTF1 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]; trichostatin A promotes the reaction [Zinc results in increased expression of MT1 mRNA]; Zinc deficiency inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Zinc inhibits the reaction [Dietary Fats results in decreased expression of MT1 mRNA]; Zinc inhibits the reaction [Dietary Fats results in decreased expression of MT1 protein]; Zinc promotes the reaction [MTF1 protein binds to MT1 promoter]
Zinc deficiency results in decreased expression of MT1 mRNA; Zinc deficiency results in decreased expression of MT1 protein
MT1 protein results in increased abundance of Zinc
MT1 protein results in decreased susceptibility to Zinc; MT1 protein results in decreased susceptibility to Zinc deficiency
[Zinc binds to MT1 protein] which binds to Mercuric Chloride; [Zinc binds to MT1 protein] which binds to mercuric perchlorate; MT1 protein binds to Zinc; Zinc binds to MT1 protein
Zinc results in increased expression of MT1 mRNA; Zinc results in increased expression of MT1 protein
Zinc results in increased expression of MT1A mRNA
MT1A protein binds to Zinc; Zinc binds to MT1A protein
1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate promotes the reaction [Zinc results in increased expression of MT1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT1A mRNA]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT1A mRNA; [Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA; chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1A mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of FABP4 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1B mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL6 mRNA]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL6 protein]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA]; tris(1,10-phenanthroline)chromium(III) chloride inhibits the reaction [Zinc results in increased expression of MT1A mRNA]; Zinc promotes the reaction [ochratoxin A results in increased expression of MT1A mRNA]
Zinc deficiency results in increased expression of MT1A mRNA; Zinc deficiency results in increased expression of MT1A protein; Zinc results in increased expression of MT1 mRNA; Zinc results in increased expression of MT1A mRNA
Zinc deficiency results in decreased expression of MT1 mRNA; Zinc deficiency results in decreased expression of MT1A mRNA
1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene promotes the reaction [Zinc results in increased expression of MT1A mRNA]; [Butyrates co-treated with Zinc] results in increased expression of MT1A mRNA; [Folic Acid co-treated with Zinc] inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; [Zinc co-treated with Iron] results in increased expression of and affects the localization of MT1A protein; [Zinc co-treated with Selenium] inhibits the reaction [Cadmium results in increased expression of MT1 mRNA]; IL1A protein inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA]; SLC30A1 protein promotes the reaction [[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; Zinc affects the reaction [Zinc deficiency results in increased expression of MT1A mRNA]; Zinc affects the reaction [Zinc deficiency results in increased expression of MT1A protein]; Zinc deficiency inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MT1 mRNA]; Zinc deficiency inhibits the reaction [IL1A protein results in increased expression of MT1A mRNA]; Zinc inhibits the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]; Zinc inhibits the reaction [Cadmium results in increased expression of MT1 mRNA]; Zinc inhibits the reaction [Homocysteine results in decreased expression of MT1A mRNA]; Zinc promotes the reaction [Butyrates results in increased expression of MT1A protein]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A mRNA]; Zinc promotes the reaction [Daunorubicin results in increased expression of MT1A protein]; Zinc promotes the reaction [Streptozocin results in increased expression of MT1A mRNA]; Zinc results in increased expression of and affects the localization of MT1A protein; Zinc Sulfate inhibits the reaction [Zinc deficiency results in decreased expression of MT1A mRNA]

PMID:1597404 PMID:2070824 PMID:2156696 PMID:2959537 PMID:3609024 More...

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

multiple interactions
affects expression
increases expression
affects binding
affects transport

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT2A mRNA]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT2A mRNA; [PCI 5002 co-treated with Zinc] results in increased expression of MT2A mRNA; [Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of MT2A mRNA; CEBPA protein inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; CEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]; chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of MT2A mRNA]; MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; Zinc deficiency inhibits the reaction [ochratoxin A results in increased expression of MT2A mRNA]; Zinc promotes the reaction [IL1A protein results in increased expression of MT2A mRNA]; Zinc promotes the reaction [IL1B protein results in increased expression of MT2A mRNA]; Zinc promotes the reaction [MTF1 protein binds to MT2A enhancer]; Zinc promotes the reaction [MTF1 protein binds to MT2A promoter]; Zinc promotes the reaction [ochratoxin A results in increased expression of MT2A mRNA]
Zinc affects the expression of MT2A protein
Zinc results in increased expression of MT2 mRNA
Zinc binds to MT2 protein
MT2 protein affects the transport of Zinc
[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; [MT1 protein co-treated with MT2 protein] promotes the reaction [SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; [MT2 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased abundance of Zinc; cerous chloride promotes the reaction [Zinc binds to MT2 protein]; MT2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]
[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of MT2A mRNA; [Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein; SLC30A1 protein promotes the reaction [[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; Zinc deficiency inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MT2A mRNA]; Zinc inhibits the reaction [Cadmium Chloride results in increased expression of MT2A]; Zinc results in increased expression of and affects the localization of MT2A protein
Zinc deficiency results in increased expression of MT2A; Zinc deficiency results in increased expression of MT2A mRNA; Zinc results in increased expression of MT2A mRNA
Zinc affects the expression of MT2A mRNA
Zinc binds to MT2A protein

PMID:1459136 PMID:1502195 PMID:2173694 PMID:2771874 PMID:2830259 More...

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

metallothionein 2, pseudogene 1

increases expression

ISO

Zinc results in increased expression of MT1HL1 mRNA

NCBI chr20:3,163,749...3,164,121

G

metallothionein 3

multiple interactions
increases expression
affects binding
affects abundance
affects response to substance

ISO
EXP

[[MT3 protein binds to Zinc] which co-treated with Ascorbic Acid] inhibits the reaction [Copper results in increased chemical synthesis of Hydroxyl Radical]; [[MT3 protein binds to Zinc] which results in increased reduction of Copper] promotes the reaction [Copper binds to [MT3 protein binds to Zinc]]; [MT3 protein binds to Zinc] which results in increased reduction of Copper; MT3 protein binds to and affects the abundance of Zinc; MT3 protein binds to and affects the transport of Zinc; Zinc inhibits the reaction [tris(1,10-phenanthroline)chromium(III) chloride results in increased activity of MT3 protein]; Zinc inhibits the reaction [tris(1,10-phenanthroline)chromium(III) chloride results in increased expression of MT3 mRNA]; Zinc promotes the reaction [decitabine results in increased expression of MT3 mRNA]; Zinc promotes the reaction [entinostat results in increased expression of MT3 mRNA]
Zinc results in increased expression of MT3 mRNA
Zinc results in increased expression of MT3 mRNA; Zinc results in increased expression of MT3 protein
Copper binds to [MT3 protein binds to Zinc]; Zinc binds to MT3 protein
MT3 protein affects the abundance of Zinc
[MT3 protein binds to RAB3A protein] which results in decreased susceptibility to Zinc; MT3 protein results in decreased susceptibility to [Neurotoxins results in increased abundance of Zinc]
MT3 protein binds to and affects the activity of Zinc
MT3 protein affects the susceptibility to Zinc

PMID:8917669 PMID:11087412 PMID:11994011 PMID:12081484 PMID:12220637 More...

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

metallothionein 4

increases expression

ISO

Zinc deficiency results in increased expression of MT4 mRNA

NCBI chr19:10,869,735...10,871,831
Ensembl chr19:10,869,735...10,871,831

G

metastasis associated 1 family, member 2

decreases expression

ISO

Zinc results in decreased expression of MTA2 mRNA

NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062

G

mitochondrial amidoxime reducing component 2

increases expression

EXP

Zinc deficiency results in increased expression of MTARC2 mRNA

NCBI chr13:98,894,347...98,928,754
Ensembl chr13:98,897,108...98,928,781

G

metal-regulatory transcription factor 1

decreases response to substance
increases activity
affects localization
increases expression
multiple interactions
affects binding
increases response to substance

ISO

MTF1 protein results in decreased susceptibility to Zinc
Zinc results in increased activity of MTF1 protein
Zinc affects the localization of MTF1 protein
Zinc results in increased expression of MTF1 mRNA; Zinc results in increased expression of MTF1 protein
[[Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC39A13 promoter]] which results in increased expression of SLC39A13 mRNA; [Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC39A13 promoter]; [Zinc binds to MTF1 protein] affects the reaction [MTF1 protein binds to MT1 promoter]; [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA; Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]; chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]]; Glutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]; MTF1 mutant form inhibits the reaction [Zinc results in decreased expression of SLC39A10 mRNA]; MTF1 mutant form inhibits the reaction [Zinc results in increased expression of SLC40A1 mRNA]; MTF1 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]; MTF1 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]; Zinc affects the localization of and results in increased activity of MTF1 protein; Zinc promotes the reaction [MTF1 protein binds to EP300 protein binds to CREBBP protein]; Zinc promotes the reaction [MTF1 protein binds to EP300 protein]; Zinc promotes the reaction [MTF1 protein binds to MT1 promoter]; Zinc promotes the reaction [MTF1 protein binds to SLC39A10 promoter]; Zinc promotes the reaction [MTF1 protein binds to SP1 protein]; Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]]; Zinc promotes the reaction [MTF1 protein results in increased expression of SLC30A2 mRNA]
Zinc deficiency results in increased expression of MTF1 mRNA; Zinc results in increased expression of MTF1 mRNA; Zinc results in increased expression of MTF1 protein
MTF1 protein results in increased susceptibility to Zinc
Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]; CEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]; Copper promotes the reaction [Zinc results in increased activity of MTF1 protein]; Glutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of HMOX1 mRNA]; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of MT1M mRNA]; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [Zinc results in increased expression of XAF1 mRNA]; MTF1 protein affects the reaction [Zinc results in increased expression of XAF1 protein]; MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]; Zinc promotes the reaction [MTF1 protein binds to HSF1 protein]; Zinc promotes the reaction [MTF1 protein binds to MT2A enhancer]; Zinc promotes the reaction [MTF1 protein binds to MT2A promoter]

PMID:1459136 PMID:8026472 PMID:9507026 PMID:10605938 PMID:10734081 More...

NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810

G

metal response element binding transcription factor 2

increases expression

ISO

Zinc deficiency results in increased expression of MTF2 mRNA

NCBI chr14:1,784,218...1,828,463
Ensembl chr14:1,783,627...1,828,414

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350

G

microsomal triglyceride transfer protein

multiple interactions
affects expression

ISO

Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein]
Zinc deficiency affects the expression of MTTP mRNA
[Ethanol co-treated with Zinc] results in increased expression of MTTP mRNA; [Zinc deficiency co-treated with Ethanol] affects the expression of MTTP mRNA

PMID:19637192 PMID:24155903

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650

G

microtubule associated scaffold protein 1

increases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of MTUS1 mRNA
Zinc deficiency results in increased expression of MTUS1 mRNA
[PCI 5002 co-treated with Zinc] results in decreased expression of MTUS1 mRNA

PMID:17074742 PMID:18356318 PMID:18593933

NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474

G

mucin 1, cell surface associated

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MUC1 mRNA
Zinc deficiency results in increased expression of MUC1 mRNA

PMID:16979875 PMID:20857495

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491

G

murinoglobulin 1

increases expression

EXP

Zinc deficiency results in increased expression of MUG1 mRNA

NCBI chr 4:156,748,351...156,802,132

G

murinoglobulin 2

affects binding

ISO

PZP protein binds to Zinc

NCBI chr 4:156,836,140...156,908,972

G

MX dynamin like GTPase 2

increases expression

EXP

Zinc deficiency results in increased expression of MX2 mRNA

NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478

G

max dimerization protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MXD1 mRNA

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129

G

MYB proto-oncogene, transcription factor

increases activity

ISO

Zinc deficiency results in increased activity of MYB protein

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

myosin binding protein C1

decreases expression

EXP

Zinc deficiency results in decreased expression of MYBPC1 mRNA

NCBI chr 7:24,817,770...24,903,681
Ensembl chr 7:24,817,561...24,903,544

G

myosin binding protein H

decreases expression

EXP

Zinc deficiency results in decreased expression of MYBPH mRNA

NCBI chr13:48,205,162...48,212,928
Ensembl chr13:48,205,269...48,212,928

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

ISO

Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein]; Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

MYCL proto-oncogene, bHLH transcription factor

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MYCL mRNA

NCBI chr 5:140,559,843...140,566,704
Ensembl chr 5:140,560,152...140,566,699

G

myeloid-derived growth factor

increases expression

ISO

Zinc deficiency results in increased expression of MYDGF mRNA

NCBI chr 9:1,086,825...1,095,968
Ensembl chr 9:1,086,825...1,095,968

G

myogenic factor 6

decreases expression

EXP

Zinc deficiency results in decreased expression of MYF6 mRNA

NCBI chr 7:44,699,469...44,701,313
Ensembl chr 7:44,699,469...44,701,313

G

myosin heavy chain 1

decreases expression

ISO

Zinc deficiency results in decreased expression of MYH1 mRNA

NCBI chr10:52,384,810...52,408,698
Ensembl chr10:52,384,908...52,409,047

G

myosin heavy chain 14

decreases expression

ISO

Zinc deficiency results in decreased expression of MYH14 mRNA

NCBI chr 1:104,232,778...104,295,369
Ensembl chr 1:104,232,778...104,323,404

G

myosin heavy chain 6

decreases expression

ISO

Zinc deficiency results in decreased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

increases expression
decreases expression

EXP
ISO

Zinc results in increased expression of MYH7 mRNA
Zinc deficiency results in decreased expression of MYH7 mRNA

PMID:17074742 PMID:18356318

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin heavy chain 8

decreases expression

EXP

Zinc deficiency results in decreased expression of MYH8 mRNA

NCBI chr10:52,462,509...52,492,105
Ensembl chr10:52,462,509...52,492,105

G

myosin, heavy chain 9

increases expression

ISO

Zinc deficiency results in increased expression of MYH9 mRNA

NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:111,224,291...111,304,963

G

myosin, light chain 1

decreases expression

EXP

Zinc deficiency results in decreased expression of MYL1 mRNA

Ensembl chr 9:75,887,227...75,907,971

G

myosin light chain 3

decreases expression

EXP

Zinc deficiency results in decreased expression of MYL3 mRNA

NCBI chr 8:119,617,077...119,623,215
Ensembl chr 8:119,616,868...119,623,216

G

myosin regulatory light chain interacting protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MYLIP mRNA

NCBI chr17:19,492,826...19,514,490
Ensembl chr17:19,492,826...19,514,471

G

myocilin

decreases expression

ISO

Zinc deficiency results in decreased expression of MYOC mRNA

NCBI chr13:77,509,963...77,520,361
Ensembl chr13:77,509,963...77,520,361

G

marginal zone B and B1 cell-specific protein

increases expression

ISO

Zinc deficiency results in increased expression of MZB1 mRNA

NCBI chr18:27,513,087...27,515,148
Ensembl chr18:27,513,089...27,515,182

G

myeloid zinc finger 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of MZF1 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MZF1 mRNA

PMID:16979875 PMID:18593933

NCBI chr 1:82,742,709...82,755,069
Ensembl chr 1:82,742,726...82,753,820

G

NEDD4 binding protein 2-like 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of N4BP2L2 mRNA

NCBI chr12:4,972,967...5,038,027
Ensembl chr12:4,972,990...5,033,405

G

N-acylethanolamine acid amidase

increases expression

ISO

Zinc deficiency results in increased expression of NAAA mRNA

NCBI chr14:16,061,599...16,080,703
Ensembl chr14:16,061,583...16,080,702

G

Ngfi-A binding protein 1

increases expression
decreases expression

ISO
EXP

Zinc deficiency results in increased expression of NAB1 mRNA
Zinc deficiency results in decreased expression of NAB1 mRNA

PMID:12672911 PMID:18356318

NCBI chr 9:56,545,547...56,585,045
Ensembl chr 9:56,545,729...56,614,210

G

Ngfi-A binding protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NAB2 mRNA

NCBI chr 7:65,382,863...65,389,527
Ensembl chr 7:65,382,863...65,389,255

G

nucleic acid binding protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NABP1 mRNA

NCBI chr 9:57,570,326...57,625,926
Ensembl chr 9:57,618,505...57,626,052

G

NAC alpha domain containing

increases expression

ISO

Zinc deficiency results in increased expression of NACAD mRNA

NCBI chr14:85,679,215...85,688,742
Ensembl chr14:85,679,215...85,688,147

G

NACC family member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NACC2 mRNA

NCBI chr 3:29,278,077...29,345,098
Ensembl chr 3:29,281,190...29,344,840

G

nicotinamide phosphoribosyltransferase

increases expression

EXP

Zinc deficiency results in increased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

nucleosome assembly protein 1-like 3

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NAP1L3 mRNA

NCBI chr X:92,607,628...92,610,426
Ensembl chr X:92,604,626...92,610,687

G

nuclear prelamin A recognition factor

increases expression

ISO

Zinc deficiency results in increased expression of NARF mRNA

NCBI chr10:107,017,344...107,035,777
Ensembl chr10:107,016,510...107,037,283

G

NAD(P)HX dehydratase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NAXD mRNA

NCBI chr16:84,689,776...84,706,256
Ensembl chr16:84,688,243...84,706,411

G

negative regulator of P-body association

affects abundance

ISO

NBDY gene SNP affects the abundance of Zinc

NCBI chr X:20,964,915...20,965,121

G

non-SMC condensin I complex, subunit G

increases expression

ISO

Zinc deficiency results in increased expression of NCAPG mRNA

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445

G

neutrophil cytosolic factor 1

increases response to substance
multiple interactions
increases expression

ISO

NCF1 results in increased susceptibility to Zinc
[Zinc deficiency co-treated with Ethanol] results in increased expression of NCF1 protein
Zinc deficiency results in increased expression of NCF1 protein

PMID:18545258 PMID:24155903

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

nuclear receptor coactivator 3

increases expression

ISO

Zinc deficiency results in increased expression of NCOA3 mRNA

NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631

G

natural cytotoxicity triggering receptor 3

increases expression

ISO

Zinc deficiency results in increased expression of NCR3 mRNA

NCBI chr20:3,642,912...3,648,425
Ensembl chr20:3,642,912...3,644,188

G

nudE neurodevelopment protein 1-like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NDEL1 mRNA

NCBI chr10:54,001,435...54,080,909
Ensembl chr10:54,016,149...54,062,375

G

N-myc downstream regulated 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NDRG1 mRNA

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913

G

NADH:ubiquinone oxidoreductase complex assembly factor 5

decreases expression

ISO

Zinc results in decreased expression of NDUFAF5 mRNA

NCBI chr 3:147,961,612...147,991,128
Ensembl chr 3:147,961,599...147,991,126

G

NADH:ubiquinone oxidoreductase core subunit V2

decreases expression

ISO

Zinc results in decreased expression of NDUFV2 protein

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

nectin cell adhesion molecule 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NECTIN2 mRNA

NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:88,500,087...88,535,305

G

NEDD4 like E3 ubiquitin protein ligase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NEDD4L mRNA

NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824

G

NEDD8 ubiquitin like modifier

increases expression

EXP

Zinc deficiency results in increased expression of NEDD8 mRNA

NCBI chr15:33,123,505...33,135,522
Ensembl chr15:33,123,505...33,135,522

G

NIMA-related kinase 2

decreases expression

ISO

Zinc deficiency results in decreased expression of NEK2 mRNA

NCBI chr13:105,936,809...105,950,054
Ensembl chr13:105,936,788...105,950,056

G

NIMA-related kinase 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NEK6 mRNA

NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:42,693,971...42,767,773

G

neurofibromin 1

decreases expression

ISO

Zinc results in decreased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

decreases expression

ISO

Zinc results in decreased expression of NF2 mRNA

NCBI chr14:83,850,894...83,934,263
Ensembl chr14:83,850,894...83,934,151

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFATC1 mRNA

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

nuclear factor of activated T-cells 4

increases localization

ISO

Zinc results in increased localization of NFATC4 protein

NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582

G

NFE2 like bZIP transcription factor 2

increases activity
multiple interactions
affects localization
decreases expression

ISO
EXP

Zinc results in increased activity of NFE2L2 promoter
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 mRNA]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 protein]
NFE2L2 protein affects the reaction [Zinc results in increased expression of HMOX1 mRNA]; Zinc deficiency promotes the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; Zinc inhibits the reaction [Dietary Fats results in decreased expression of and affects the localization of NFE2L2 protein]
Zinc deficiency affects the localization of NFE2L2 protein
Zinc deficiency results in decreased expression of NFE2L2 protein

PMID:10473555 PMID:21078376 PMID:21643505 PMID:23377617 PMID:27370414 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFE2 like bZIP transcription factor 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFE2L3 mRNA

NCBI chr 4:81,837,404...81,865,258
Ensembl chr 4:81,837,404...81,865,532

G

nuclear factor I/B

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NFIB mRNA

NCBI chr 5:101,805,168...102,020,618
Ensembl chr 5:101,805,168...102,019,945

G

nuclear factor I/C

multiple interactions
decreases expression
affects localization

ISO

[Zinc deficiency promotes the reaction [NFIC protein binds to SLC39A13 protein]] which results in decreased expression of SLC39A13 mRNA; Zinc deficiency promotes the reaction [NFIC protein binds to SLC39A13 protein]; Zinc inhibits the reaction [NFIC protein binds to DSPP promoter]; Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein]
Zinc results in decreased expression of NFIC mRNA; Zinc results in decreased expression of NFIC protein
Zinc deficiency affects the localization of NFIC protein

NCBI chr 7:8,928,423...8,963,455
Ensembl chr 7:8,904,117...8,963,409

G

nuclear factor, interleukin 3 regulated

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

nuclear factor kappa B subunit 1

decreases expression
affects localization
multiple interactions

ISO
EXP

Zinc results in decreased expression of NFKB1 protein
Zinc deficiency affects the localization of NFKB1 protein
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of NFKB1 protein]
[Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of NFKB1 protein; Acetylcysteine inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein]

PMID:16472982 PMID:17029595 PMID:18615482 PMID:19589337 PMID:21600978 More...

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

increases expression
decreases expression

ISO

Zinc deficiency results in increased expression of NFKB2 mRNA
Zinc deficiency results in decreased expression of NFKB2 mRNA

PMID:18356318 PMID:22171008

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

multiple interactions

ISO

[Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of BCL2 protein; [Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of NFKB1 protein; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]; Zinc inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]

PMID:16606632 PMID:17029595 PMID:18615482

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor delta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFKBID mRNA

NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:94,808,453...94,817,861

G

NFKB inhibitor epsilon

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

NFKB inhibitor like 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NFKBIL1 mRNA

NCBI chr20:3,595,319...3,610,295
Ensembl chr20:3,595,284...3,610,294

G

NFKB inhibitor zeta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767

G

nuclear transcription factor, X-box binding 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NFX1 mRNA

NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:60,901,217...60,958,889

G

neuroglobin

decreases uptake

ISO

NGB protein results in decreased uptake of Zinc

NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786

G

neugrin, neurite outgrowth associated

decreases expression

ISO

Zinc deficiency results in decreased expression of NGRN mRNA

NCBI chr 1:143,622,494...143,628,609
Ensembl chr 1:143,622,731...143,628,609

G

ninein-like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NINL mRNA

NCBI chr 3:160,208,757...160,275,077
Ensembl chr 3:160,196,883...160,275,108

G

NIPA magnesium transporter 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NIPA1 mRNA

NCBI chr 1:115,608,221...116,010,503
Ensembl chr 1:115,974,481...116,010,812

G

NFKB repressing factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NKRF mRNA

NCBI chr X:120,992,038...121,010,251
Ensembl chr X:120,992,038...121,010,251

G

NK3 homeobox 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NKX3-1 mRNA

NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251

G

NLR family, pyrin domain containing 12

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of NLRP12 mRNA

NCBI chr 1:74,848,020...74,885,945
Ensembl chr 1:74,848,063...74,876,341

G

NLR family, pyrin domain containing 1A

increases expression

ISO

Zinc deficiency results in increased expression of NLRP1 mRNA

NCBI chr10:56,277,134...56,332,229
Ensembl chr10:56,277,134...56,323,880

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 1

affects binding
decreases expression

ISO

NME1 protein binds to Zinc
Zinc deficiency results in decreased expression of NME1 mRNA

PMID:12888634 PMID:14534351

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

NME/NM23 nucleoside diphosphate kinase 2

increases expression

EXP

Zinc deficiency results in increased expression of NME2 mRNA

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

nicotinamide nucleotide adenylyltransferase 1

decreases response to substance
multiple interactions

ISO

NMNAT1 protein results in decreased susceptibility to Zinc
[zinc chloride results in increased abundance of Zinc] which results in increased expression of NMNAT1 mRNA

PMID:17042794 PMID:31588059

NCBI chr 5:165,193,301...165,211,213
Ensembl chr 5:165,193,302...165,211,231

G

nucleolar protein 3

increases expression

ISO

Zinc deficiency results in increased expression of NOL3 mRNA

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

NOP58 ribonucleoprotein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NOP58 mRNA

NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909

G

nitric oxide synthase 2

multiple interactions
increases expression
affects localization

ISO
EXP

NOS2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]
Zinc deficiency results in increased expression of NOS2 mRNA; Zinc deficiency results in increased expression of NOS2 protein
NOS2 protein affects the localization of Zinc
[IL1A protein co-treated with Zinc deficiency] results in increased expression of NOS2 protein; [Zinc deficiency co-treated with IL1A protein] results in increased expression of NOS2 mRNA; IL1A protein promotes the reaction [Zinc deficiency results in increased expression of NOS2 mRNA]

PMID:9278552 PMID:12514266 PMID:14617770

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression

EXP

Zinc deficiency results in increased expression of NOS3

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 1

multiple interactions
affects localization
decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]; Wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; Wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

NADPH oxidase 1

decreases expression

ISO

Zinc deficiency results in decreased expression of NOX1 mRNA

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

NADPH oxidase 4

increases expression

ISO

Zinc results in increased expression of NOX4 mRNA

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

neuronal PAS domain protein 2

multiple interactions

ISO

[Zinc Sulfate results in increased abundance of Zinc] which results in decreased expression of NPAS2 mRNA

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

NPC intracellular cholesterol transporter 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NPC1 mRNA

NCBI chr18:3,654,237...3,699,853
Ensembl chr18:3,654,237...3,699,800

G

nucleophosmin 1

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of NPM1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of NPM1 mRNA]

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

neuropeptide Y

decreases expression

EXP

Zinc deficiency results in decreased expression of NPY mRNA

PMID:12672911 PMID:16413754

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NQO1 mRNA
Zinc deficiency promotes the reaction [Dietary Fats results in decreased expression of NQO1 mRNA]; Zinc deficiency promotes the reaction [Dietary Fats results in decreased expression of NQO1 protein]; Zinc inhibits the reaction [Dietary Fats results in decreased expression of NQO1 mRNA]; Zinc inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]; Zinc promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]

PMID:14998373 PMID:16979875 PMID:27370414

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

affects expression
multiple interactions

ISO

Zinc affects the expression of NQO2 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of NQO2 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NQO2 mRNA

PMID:16979875 PMID:18593933

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 1, group D, member 2

increases expression

EXP

Zinc results in increased expression of NR1D2 mRNA

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 1, group H, member 3

decreases expression

ISO

Zinc results in decreased expression of NR1H3 mRNA

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 2, group C, member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NR2C2 mRNA

NCBI chr 4:126,167,350...126,223,942
Ensembl chr 4:126,168,085...126,223,942

G

nuclear receptor subfamily 3, group C, member 1

affects binding
multiple interactions

EXP
ISO

Zinc binds to NR3C1 protein
Zinc affects the reaction [mineral acids, trace elements, water, drug combination results in increased expression of NR3C1 protein]
Zinc inhibits the reaction [Cobalt binds to NR3C1 protein]

PMID:8548200 PMID:14640689

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NR4A1 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A1 mRNA
Zinc deficiency results in increased expression of NR4A1 mRNA

PMID:16979875 PMID:18356318 PMID:18593933

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NR4A2 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A2 mRNA

PMID:16979875 PMID:18593933

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions
decreases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of NR4A3 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A3 mRNA
Zinc deficiency results in decreased expression of NR4A3 mRNA

PMID:16979875 PMID:18593933 PMID:19111725

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

Notch-regulated ankyrin repeat protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NRARP mRNA

NCBI chr 3:28,390,745...28,393,299
Ensembl chr 3:28,390,733...28,393,453

G

nuclear receptor binding factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NRBF2 mRNA

NCBI chr20:21,307,389...21,325,724
Ensembl chr20:21,290,787...21,325,724

G

nuclear respiratory factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NRF1 mRNA

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

neuropilin 1

decreases expression

ISO

Zinc deficiency results in decreased expression of NRP1 mRNA

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

neuropilin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NRP2 mRNA

NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871

G

neurturin

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of NRTN mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of NRTN mRNA]

NCBI chr 9:1,669,099...1,674,957
Ensembl chr 9:1,641,618...1,675,133

G

5'-nucleotidase domain containing 2

increases expression

ISO

Zinc deficiency results in increased expression of NT5DC2 mRNA

NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,328,523...6,336,980

G

netrin 3

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of NTN3 mRNA

NCBI chr10:13,741,459...13,744,555
Ensembl chr10:13,741,459...13,744,555

G

neurotrophic receptor tyrosine kinase 2

increases expression
decreases phosphorylation

ISO

Zinc deficiency results in increased expression of NTRK2 mRNA
Zinc deficiency results in decreased phosphorylation of NTRK2 protein

PMID:18356318 PMID:20101602

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

nuclear distribution C, dynein complex regulator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NUDC mRNA

NCBI chr 5:151,041,878...151,055,260
Ensembl chr 5:151,041,875...151,055,260

G

nudix hydrolase 11

decreases expression

ISO

Zinc deficiency results in decreased expression of NUDT11 mRNA

NCBI chr X:18,998,587...19,005,208
Ensembl chr X:18,998,461...19,005,208

G

nudix hydrolase 16 like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NUDT16L1 mRNA

NCBI chr10:11,142,626...11,144,542
Ensembl chr10:11,142,627...11,144,764

G

nuclear FMR1 interacting protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NUFIP2 mRNA

NCBI chr10:63,072,964...63,105,823
Ensembl chr10:63,073,397...63,105,823

G

nucleoporin 98 and 96 precursor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NUP98 mRNA

NCBI chr 1:165,906,405...166,003,366
Ensembl chr 1:165,906,405...166,003,366

G

nucleolar and spindle associated protein 1

increases expression

ISO

Zinc deficiency results in increased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:127,057,265...127,087,237

G

nuclear RNA export factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of NXF1 mRNA

NCBI chr 1:215,084,563...215,097,756
Ensembl chr 1:215,084,099...215,097,756

G

neurexophilin 4

decreases expression

ISO

Zinc results in decreased expression of NXPH4 mRNA

NCBI chr 7:65,253,043...65,261,864
Ensembl chr 7:65,252,904...65,261,864

G

oncomodulin

multiple interactions
increases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in increased expression of OCM mRNA]

NCBI chr12:15,649,452...15,710,375
Ensembl chr12:15,676,520...15,710,379

G

oxoglutarate dehydrogenase

decreases activity

ISO

Zinc results in decreased activity of OGDH protein

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

opioid receptor, delta 1

multiple interactions

EXP

Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]; Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]

NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999

G

opioid receptor, mu 1

multiple interactions

ISO
EXP

[Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]]; calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; calphostin complex inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]; RGS17 protein affects the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Zinc inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Zinc inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Zinc promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Zinc promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]; Zinc promotes the reaction [OPRM1 protein binds to PRKCB protein]; Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]; Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]; Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]; Zinc promotes the reaction [OPRM1 protein binds to RGS17 protein]
Zinc inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Zinc inhibits the reaction [Magnesium promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]; Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]

PMID:2162496 PMID:18652891 PMID:21235400

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

olfactory receptor family 1 subfamily D member 2

decreases expression

ISO

Zinc results in decreased expression of OR1D2 mRNA

NCBI chr10:59,711,377...59,712,312
Ensembl chr10:59,711,377...59,712,312

G

olfactory receptor family 2 subfamily AG member 1

increases expression

ISO

Zinc deficiency results in increased expression of OR2AG1 mRNA

NCBI chr 1:170,095,543...170,096,493
Ensembl chr 1:170,095,543...170,096,493

G

olfactory receptor family 2 subfamily AG member 2

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of OR2AG2 mRNA

NCBI chr 1:170,107,441...170,108,391
Ensembl chr 1:170,107,441...170,108,391

G

olfactory receptor family 4 subfamily C member 12

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in decreased expression of OR4C12 mRNA

NCBI chr 3:96,403,378...96,404,298
Ensembl chr 3:96,403,378...96,404,298

G

oxysterol binding protein-like 1A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of OSBPL1A mRNA

NCBI chr18:4,178,734...4,383,511
Ensembl chr18:4,179,631...4,369,421

G

oxysterol binding protein-like 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of OSBPL3 mRNA

NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169

G

oxidative stress responsive serine-rich 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of OSER1 mRNA

NCBI chr 3:172,486,417...172,504,607
Ensembl chr 3:172,486,440...172,504,597

G

oxidative stress induced growth inhibitor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

OTU deubiquitinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of OTUD1 mRNA

NCBI chr17:87,168,248...87,171,098
Ensembl chr17:87,149,175...87,330,706

G

OTU deubiquitinase 5

increases expression

ISO

Zinc deficiency results in increased expression of OTUD5 mRNA

NCBI chr X:17,296,750...17,331,257
Ensembl chr X:17,298,029...17,331,054

G

3-oxoacid CoA transferase 2B

increases expression

ISO

Zinc deficiency results in increased expression of OXCT2 mRNA

NCBI chr 5:140,681,746...140,683,500
Ensembl chr 5:140,671,211...140,696,448

G

oxidative stress responsive kinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of OXSR1 mRNA

NCBI chr 8:127,850,481...127,941,518
Ensembl chr 8:127,850,484...127,939,750

G

purinergic receptor P2X 2

multiple interactions
decreases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in decreased expression of P2RX2 mRNA]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]

PMID:19111725 PMID:19793987

NCBI chr12:51,999,107...52,002,627
Ensembl chr12:51,999,372...52,002,627

G

purinergic receptor P2X 4

multiple interactions

EXP

[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Copper inhibits the reaction [Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]]; Zinc promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

PMID:10737610 PMID:15629187 PMID:19793987

NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094

G

purinergic receptor P2Y2

decreases expression

EXP

Zinc deficiency results in decreased expression of P2RY2 mRNA

NCBI chr 1:164,764,119...164,779,578
Ensembl chr 1:164,759,213...164,781,852

G

pyrimidinergic receptor P2Y6

decreases expression

ISO

Zinc results in decreased expression of P2RY6 mRNA

NCBI chr 1:164,707,188...164,742,689
Ensembl chr 1:164,706,116...164,743,588

G

prolyl 4-hydroxylase subunit alpha 1

increases expression

EXP

Zinc deficiency results in increased expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

prolyl 4-hydroxylase subunit alpha 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of P4HA2 mRNA

NCBI chr10:38,743,894...38,772,741
Ensembl chr10:38,743,894...38,772,993

G

prolyl 4-hydroxylase subunit beta

affects binding
increases expression

ISO

P4HB protein binds to Zinc
Zinc deficiency results in increased expression of P4HB mRNA

PMID:14534351 PMID:22171008

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

proton activated chloride channel 1

decreases expression

ISO

Zinc deficiency results in decreased expression of PACC1 mRNA

NCBI chr13:105,435,772...105,460,877
Ensembl chr13:105,435,799...105,461,095

G

parkin coregulated like

increases expression

ISO

Zinc deficiency results in increased expression of PACRGL mRNA

NCBI chr14:66,744,625...66,769,593
Ensembl chr14:66,744,625...66,769,631

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PAFAH1B1 mRNA

NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196

G

paralemmin A kinase anchor protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PALM2AKAP2 mRNA

NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656

G

partner and localizer of BRCA2

decreases expression

ISO

Zinc deficiency results in decreased expression of PALB2 mRNA

NCBI chr 1:186,096,312...186,120,284
Ensembl chr 1:186,096,312...186,120,302

G

poly(A) specific ribonuclease subunit PAN2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PAN2 mRNA

NCBI chr 7:1,313,654...1,332,252
Ensembl chr 7:1,313,655...1,332,252

G

pantothenate kinase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PANK2 mRNA

NCBI chr 3:138,936,448...138,974,196
Ensembl chr 3:138,936,452...138,974,194

G

par-6 family cell polarity regulator gamma

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PARD6G mRNA

NCBI chr18:75,772,992...75,840,041
Ensembl chr18:75,772,955...75,840,041

G

prostate androgen-regulated mucin-like protein 1

increases expression

ISO

Zinc deficiency results in increased expression of PARM1 mRNA

NCBI chr14:16,752,541...16,861,570
Ensembl chr14:16,752,541...16,881,138

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases folding
affects binding
increases cleavage
decreases expression

ISO
EXP

[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Cisplatin inhibits the reaction [Zinc binds to PARP1 protein]; Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of PARP1 protein]; imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) inhibits the reaction [Zinc binds to PARP1 protein]; linsidomine inhibits the reaction [PARP1 protein binds to Zinc]; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to PARP1 protein]; Organogold Compounds inhibits the reaction [Zinc binds to PARP1 protein]; RAPTA-T inhibits the reaction [Zinc binds to PARP1 protein]; sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]; sodium arsenite inhibits the reaction [Zinc binds to PARP1 protein]; Uric Acid inhibits the reaction [sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]]; Zinc affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]; Zinc binds to and results in increased activity of PARP1 protein; Zinc deficiency promotes the reaction [Dopamine results in increased cleavage of PARP1 protein]; Zinc inhibits the reaction [arsenite results in decreased activity of PARP1 protein]; Zinc inhibits the reaction [monomethylarsonous acid results in decreased activity of PARP1 protein]; Zinc inhibits the reaction [sodium arsenite inhibits the reaction [Zinc binds to PARP1 protein]]; Zinc inhibits the reaction [sodium arsenite results in decreased activity of PARP1 protein]
Zinc results in increased folding of PARP1 protein
PARP1 protein binds to Zinc; PARP1 protein modified form binds to Zinc; Zinc binds to PARP1 protein
PARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate]; PARP1 protein affects the reaction [Zinc results in decreased uptake of Excitatory Amino Acid Agents]; Zinc inhibits the reaction [sodium arsenite results in decreased activity of PARP1 protein]
Zinc deficiency results in increased cleavage of PARP1 protein; Zinc results in increased cleavage of PARP1 protein
Zinc results in decreased expression of PARP1 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Zinc results in decreased expression of PARP1 protein]; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased cleavage of PARP1 protein; Metipranolol inhibits the reaction [Zinc results in decreased expression of PARP1 protein]

PMID:15966574 PMID:16472982 PMID:16799065 PMID:17728843 PMID:18707137 More...

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

paired box 6

decreases expression
multiple interactions

ISO
EXP

Zinc deficiency results in decreased expression of PAX6 mRNA
Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PAX6 protein]

PMID:18356318 PMID:35841924

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763

G

protocadherin alpha 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCDHA2 mRNA

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

proliferating cell nuclear antigen

multiple interactions

ISO

[Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

procollagen C-endopeptidase enhancer

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCOLCE mRNA

NCBI chr12:24,720,972...24,727,287
Ensembl chr12:24,720,936...24,727,287

G

Purkinje cell protein 4

decreases expression

ISO
EXP

Zinc deficiency results in decreased expression of PCP4 mRNA

PMID:18356318 PMID:19111725

NCBI chr11:49,229,185...49,331,186
Ensembl chr11:49,270,186...49,331,186

G

prenylcysteine oxidase 1

increases expression

ISO

Zinc deficiency results in increased expression of PCYOX1 mRNA

NCBI chr 4:120,389,545...120,400,382
Ensembl chr 4:120,388,180...120,400,382

G

phosphate cytidylyltransferase 1A, choline

affects expression

EXP

Zinc affects the expression of PCYT1A mRNA

NCBI chr11:81,818,914...81,862,623
Ensembl chr11:81,819,285...81,862,395

G

programmed cell death 4

decreases expression

EXP

Zinc deficiency results in decreased expression of PDCD4 protein

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

phosphodiesterase 4A

increases expression

ISO

Zinc deficiency results in increased expression of PDE4A mRNA

NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924

G

phosphodiesterase 4D

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PDE4D mRNA

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569

G

phosphodiesterase 4D interacting protein

increases expression

ISO

Zinc deficiency results in increased expression of PDE4DIP mRNA

NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869

G

platelet derived growth factor receptor beta

multiple interactions

EXP

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

protein disulfide isomerase family A, member 3

affects binding

ISO

PDIA3 protein binds to Zinc

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 4

increases expression

ISO

Zinc deficiency results in increased expression of PDIA4 mRNA

NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191

G

protein disulfide isomerase family A, member 5

increases expression

ISO

Zinc deficiency results in increased expression of PDIA5 mRNA

NCBI chr11:78,777,436...78,892,370
Ensembl chr11:78,777,419...78,864,329

G

protein disulfide isomerase family A, member 6

decreases expression

EXP

Zinc results in decreased expression of PDIA6 mRNA

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

pyruvate dehydrogenase kinase 1

increases expression

ISO

Zinc deficiency results in increased expression of PDK1 mRNA

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145

G

pyruvate dehydrogenase kinase 2

increases expression

EXP

Zinc results in increased expression of PDK2 mRNA

NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355

G

pyruvate dehydrogenase kinase 4

increases expression

EXP

Zinc results in increased expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 1

increases expression

EXP

Zinc deficiency results in increased expression of PDLIM1 mRNA

NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:248,991,818...249,047,379

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

increases expression

EXP

Zinc results in increased expression of PDP1 mRNA

NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960

G

pyruvate dehydrogenase phosphatase catalytic subunit 2

decreases expression

EXP

Zinc results in decreased expression of PDP2 mRNA

NCBI chr19:392,858...400,529
Ensembl chr19:392,183...400,902

G

p53 and DNA damage regulated 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PDRG1 mRNA

NCBI chr 3:161,937,812...161,943,981
Ensembl chr 3:161,937,815...161,948,995

G

pancreatic and duodenal homeobox 1

multiple interactions

EXP

Zinc deficiency affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PDX1 mRNA]

NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156

G

proliferation and apoptosis adaptor protein 15

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PEA15 mRNA

NCBI chr13:87,190,189...87,199,811
Ensembl chr13:87,187,295...87,199,859

G

paternally expressed 3

decreases expression

ISO

Zinc results in decreased expression of PEG3 mRNA

NCBI chr 1:76,130,965...76,157,774
Ensembl chr 1:76,130,948...76,157,743

G

phosphatidylethanolamine N-methyltransferase

increases expression

ISO

Zinc results in increased expression of PEMT mRNA

NCBI chr10:45,275,434...45,349,651
Ensembl chr10:45,275,412...45,420,037

G

proenkephalin

decreases expression

ISO

Zinc deficiency results in decreased expression of PENK mRNA

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705

G

period circadian regulator 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PER1 mRNA

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of PER2 mRNA; [Zinc Sulfate results in increased abundance of Zinc] which results in decreased expression of PER2 mRNA

PMID:33549593 PMID:36450499

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

period circadian regulator 3

decreases expression

ISO

Zinc deficiency results in decreased expression of PER3 mRNA

NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:166,743,050...166,777,999

G

peroxisomal biogenesis factor 1

increases expression

ISO

Zinc deficiency results in increased expression of PEX1 mRNA

NCBI chr 4:31,474,670...31,513,621
Ensembl chr 4:31,470,845...31,513,811

G

platelet factor 4

multiple interactions

ISO

[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

decreases expression

EXP

Zinc results in decreased expression of PFKFB2 mRNA

NCBI chr13:44,683,499...44,727,135
Ensembl chr13:44,699,744...44,726,971

G

phosphofructokinase, liver type

decreases expression

EXP

Zinc results in decreased expression of PFKL mRNA

NCBI chr20:10,663,907...10,685,967
Ensembl chr20:10,663,955...10,685,966

G

phosphofructokinase, muscle

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PFKM protein]

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

phosphoglycerate mutase 2

decreases expression

EXP

Zinc deficiency results in decreased expression of PGAM2 mRNA

NCBI chr14:84,895,763...84,897,874
Ensembl chr14:84,895,744...84,897,894

G

phosphogluconate dehydrogenase

decreases expression

ISO

Zinc results in decreased expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

placental growth factor

increases expression
multiple interactions

ISO

Zinc results in increased expression of PGF mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of PGF mRNA

PMID:16870260 PMID:18593933

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747

G

phosphoglycerate kinase 1

increases expression

ISO

Zinc results in increased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

peptidoglycan recognition protein 2

affects binding

ISO

PGLYRP2 protein binds to Zinc; Zinc binds to PGLYRP2 protein

PMID:14506276 PMID:23896426

NCBI chr 7:12,069,414...12,082,437
Ensembl chr 7:12,069,414...12,078,369

G

progesterone receptor membrane component 1

decreases expression

EXP

Zinc deficiency results in decreased expression of PGRMC1 mRNA

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

polyhomeotic homolog 3

decreases expression

ISO

Zinc deficiency results in decreased expression of PHC3 mRNA

NCBI chr 2:114,337,180...114,412,132
Ensembl chr 2:114,337,227...114,405,816

G

phosphoglycerate dehydrogenase

increases expression

ISO

Zinc deficiency results in increased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

pleckstrin homology-like domain, family A, member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

pleckstrin homology-like domain, family A, member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PHLDA2 mRNA

NCBI chr 1:208,126,302...208,127,241
Ensembl chr 1:208,126,302...208,127,920

G

phytanoyl-CoA 2-hydroxylase

decreases expression

EXP

Zinc deficiency results in decreased expression of PHYH mRNA

PMID:12672911 PMID:15671213

NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645

G

polymeric immunoglobulin receptor

increases expression

ISO

Zinc deficiency results in increased expression of PIGR mRNA

NCBI chr13:44,851,001...44,879,143
Ensembl chr13:44,851,182...44,879,141

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

increases expression

ISO

Zinc results in increased expression of PIK3C2A mRNA

NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

affects expression

EXP

Zinc affects the expression of PIK3C3 mRNA

NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539

G

phosphoinositide-3-kinase regulatory subunit 3

increases expression

ISO

Zinc results in increased expression of PIK3R3 mRNA

NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762

G

phosphoinositide-3-kinase, regulatory subunit 4

increases expression

ISO

Zinc results in increased expression of PIK3R4 mRNA

NCBI chr 8:115,146,660...115,195,326
Ensembl chr 8:115,146,687...115,195,326

G

phosphoinositide-3-kinase, regulatory subunit 5

increases expression

ISO

Zinc results in increased expression of PIK3R5 mRNA

NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539

G

Pim-2 proto-oncogene, serine/threonine kinase

increases expression

ISO

Zinc deficiency results in increased expression of PIM2 mRNA

NCBI chr X:17,289,509...17,294,778
Ensembl chr X:17,289,509...17,294,778

G

Pim-3 proto-oncogene, serine/threonine kinase

increases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of PIM3 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of PIM3 mRNA

PMID:17074742 PMID:18593933

NCBI chr 7:121,822,076...121,836,257
Ensembl chr 7:121,832,742...121,836,259

G

PICALM interacting mitotic regulator

decreases expression

ISO

Zinc results in decreased expression of PIMREG mRNA

NCBI chr10:57,168,136...57,173,713
Ensembl chr10:57,167,797...57,173,063

G

phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PIP4P1 mRNA

NCBI chr15:26,620,399...26,624,369
Ensembl chr15:26,620,401...26,624,246

G

PITH domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PITHD1 mRNA

NCBI chr 5:153,489,529...153,500,025
Ensembl chr 5:153,489,529...153,500,261

G

praja ring finger ubiquitin ligase 1

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of PJA1 mRNA

NCBI chr X:68,621,101...68,626,001
Ensembl chr X:68,620,084...68,638,407

G

cAMP-dependent protein kinase inhibitor alpha

increases expression

EXP

Zinc results in increased expression of PKIA mRNA

NCBI chr 2:96,306,181...96,380,959
Ensembl chr 2:96,306,184...96,321,262

G

pyruvate kinase M1/2

decreases expression

ISO

Zinc results in decreased expression of PKM protein

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

PBX/knotted 1 homeobox 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PKNOX1 mRNA

NCBI chr20:9,664,120...9,706,328
Ensembl chr20:9,664,312...9,706,349

G

phospholipase A2, group XIIB

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLA2G12B mRNA

NCBI chr20:27,910,620...27,931,734
Ensembl chr20:27,913,259...27,932,148

G

phospholipase A2 group 4A

increases expression

EXP

Zinc results in increased expression of PLA2G4A mRNA

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

PLAG1 like zinc finger 1

decreases expression

EXP

Zinc deficiency results in decreased expression of PLAGL1 mRNA

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:9,330,204...9,337,394

G

PLAG1 like zinc finger 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLAGL2 mRNA

NCBI chr 3:162,155,554...162,168,748
Ensembl chr 3:162,155,554...162,168,748

G

plasminogen activator, tissue type

multiple interactions
increases expression
increases secretion

ISO
EXP

4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT protein]; BDNF protein affects the reaction [Zinc results in increased expression of PLAT mRNA]; BDNF protein affects the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT protein]; staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT protein]; Tetanus Toxin inhibits the reaction [Zinc results in increased secretion of PLAT protein]; Zinc results in increased expression of and results in increased activity of PLAT protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of PLAT mRNA]

PMID:19111725 PMID:21615740

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

plasminogen activator, urokinase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase C, beta 4

increases expression

EXP

Zinc results in increased expression of PLCB4 mRNA

NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113

G

phospholipase D family, member 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLD6 mRNA

NCBI chr10:45,078,081...45,080,732
Ensembl chr10:45,077,080...45,087,160

G

plasminogen

multiple interactions
affects binding
increases expression

ISO

4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG protein]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLG mRNA]; 4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLG protein]; BDNF protein affects the reaction [Zinc results in increased expression of PLG mRNA]; BDNF protein affects the reaction [Zinc results in increased expression of PLG protein]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLG protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLG mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLG protein]; staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLG mRNA]; staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLG protein]
PLG protein binds to Zinc
Zinc results in increased expression of PLG mRNA; Zinc results in increased expression of PLG protein

PMID:21615740 PMID:23896426

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320

G

polo-like kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLK3 mRNA

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

pyridoxal phosphate binding protein

increases expression

ISO

Zinc deficiency results in increased expression of PLPBP mRNA

NCBI chr16:71,705,064...71,717,726
Ensembl chr16:71,700,028...71,717,726

G

phospholipid phosphatase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PLPP3 mRNA

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

pro-melanin-concentrating hormone

increases expression

EXP

Zinc results in increased expression of PMCH mRNA

NCBI chr 7:24,399,404...24,400,720
Ensembl chr 7:24,399,404...24,400,720

G

prostate transmembrane protein, androgen induced 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649

G

PML nuclear body scaffold

increases expression
affects binding
multiple interactions

ISO

Zinc results in increased expression of PML protein mutant form
Zinc binds to PML protein
sodium arsenite inhibits the reaction [Zinc binds to PML protein]

PMID:16330433 PMID:36087615

NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083

G

PMS1 homolog 1, mismatch repair system component

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PMS1 mRNA

NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:55,745,374...55,832,221

G

PARN like ribonuclease domain containing exonuclease 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PNLDC1 mRNA

NCBI chr 1:50,390,884...50,409,457
Ensembl chr 1:50,390,918...50,409,457

G

pancreatic lipase-related protein 1

decreases expression

EXP

Zinc deficiency results in decreased expression of PNLIPRP1 mRNA

NCBI chr 1:267,854,027...267,869,654
Ensembl chr 1:267,854,027...267,869,654

G

pancreatic lipase related protein 2

decreases expression

EXP

Zinc deficiency results in decreased expression of PNLIPRP2 mRNA

NCBI chr 1:267,883,906...267,902,572
Ensembl chr 1:267,883,906...267,902,572

G

phenylethanolamine-N-methyltransferase

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of PNMT mRNA

NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,881,185...83,882,849

G

pinin, desmosome associated protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PNN mRNA

NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:82,492,978...82,501,933

G

patatin-like phospholipase domain containing 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PNPLA8 mRNA

NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:67,056,697...67,120,512

G

protein O-fucosyltransferase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of POFUT2 mRNA

NCBI chr20:11,366,636...11,378,252
Ensembl chr20:11,366,636...11,377,824

G

DNA polymerase theta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of POLQ mRNA

NCBI chr11:77,179,190...77,281,270
Ensembl chr11:77,179,209...77,281,268

G

RNA polymerase II subunit A

increases expression

ISO

Zinc deficiency results in increased expression of POLR2A mRNA

PMID:18356318 PMID:22171008

NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,951,162...54,977,179

G

paraoxonase 1

affects binding

ISO

PON1 protein binds to Zinc

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

POP5 homolog, ribonuclease P/MRP subunit

decreases expression

ISO

Zinc deficiency results in decreased expression of POP5 mRNA

NCBI chr12:47,037,451...47,045,778
Ensembl chr12:47,029,403...47,042,032

G

cytochrome p450 oxidoreductase

increases expression
decreases expression

EXP

Zinc deficiency results in increased expression of POR mRNA; Zinc deficiency results in increased expression of POR protein; Zinc results in increased expression of POR mRNA
Zinc deficiency results in decreased expression of POR mRNA

PMID:8069767 PMID:12672911 PMID:17074742 PMID:19111725

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

POU class 1 homeobox 1

decreases expression

EXP

Zinc deficiency results in decreased expression of POU1F1 mRNA

NCBI chr11:16,763,312...16,781,295
Ensembl chr11:16,763,552...16,781,292

G

POU class 2 homeobox associating factor 1

increases expression

ISO

Zinc deficiency results in increased expression of POU2AF1 mRNA

NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:60,436,844...60,445,176

G

POU class 2 homeobox 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of POU2F2 mRNA

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:89,812,093...89,897,564

G

POU class 4 homeobox 3

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of POU4F3 mRNA

NCBI chr18:34,641,191...34,643,783
Ensembl chr18:34,641,191...34,643,783

G

inorganic pyrophosphatase 2

decreases expression

ISO

Zinc results in decreased expression of PPA2 protein

NCBI chr 2:224,472,738...224,552,101
Ensembl chr 2:224,474,823...224,552,628

G

peroxisome proliferator activated receptor alpha

decreases expression
increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of PPARA mRNA
Zinc results in increased expression of PPARA protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PPARA protein]
[Ethanol co-treated with Zinc] results in increased expression of PPARA mRNA; [Zinc deficiency co-treated with Ethanol] results in decreased expression of PPARA mRNA; Zinc inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of PPARA protein]

PMID:15671213 PMID:19637192 PMID:20427734 PMID:24155903

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPARD mRNA

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of PPARG mRNA
[LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of PPARG mRNA
Zinc deficiency results in decreased expression of PPARG mRNA

PMID:16140885 PMID:18593933 PMID:20128680

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

pro-platelet basic protein

increases expression

ISO

Zinc deficiency results in increased expression of PPBP mRNA

NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299

G

phosphopantothenoylcysteine decarboxylase

affects abundance

ISO

PPCDC gene SNP affects the abundance of Zinc

NCBI chr 8:66,711,115...66,738,782
Ensembl chr 8:66,711,115...66,739,011

G

periphilin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPHLN1 mRNA

NCBI chr 7:126,418,042...126,509,430
Ensembl chr 7:126,417,555...126,509,430

G

peptidylprolyl isomerase A

decreases expression

ISO

Zinc deficiency results in decreased expression of PPIA mRNA

PMID:18356318 PMID:22171008

NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115

G

peptidylprolyl isomerase F

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPIF mRNA

NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

increases expression

ISO

Zinc deficiency results in increased expression of PPM1A mRNA

NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

decreases expression

EXP

Zinc results in decreased expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

protein phosphatase 1, regulatory subunit 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPP1R10 mRNA

NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,827,802...2,842,418

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of PPP1R15A mRNA
Zinc deficiency results in increased expression of PPP1R15A mRNA

PMID:18593933 PMID:19111725

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 1, regulatory subunit 18

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPP1R18 mRNA

NCBI chr20:2,882,370...2,892,329
Ensembl chr20:2,882,369...2,896,605

G

protein phosphatase 1, regulatory subunit 36

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPP1R36 mRNA

NCBI chr 6:100,874,397...100,894,764
Ensembl chr 6:100,874,374...100,894,756

G

protein phosphatase 1, regulatory subunit 3G

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of PPP1R3G mRNA

NCBI chr17:29,080,407...29,083,739
Ensembl chr17:29,070,658...29,085,135

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

ISO

Zinc inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased activity of PPP2CA protein]

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPP2CB mRNA

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

EXP

Zinc deficiency results in increased expression of PPP2R1A mRNA; Zinc deficiency results in increased expression of PPP2R1A protein

NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242

G

protein phosphatase 2, regulatory subunit B, alpha

decreases expression

EXP

Zinc deficiency results in decreased expression of PPP2R2A protein

NCBI chr15:45,380,142...45,439,428
Ensembl chr15:45,379,683...45,439,405

G

protein phosphatase 3, regulatory subunit B, alpha

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PPP3R1 mRNA

NCBI chr14:95,758,333...95,808,015

G

proline-rich protein BstNI subfamily 1

decreases expression

ISO

Zinc deficiency results in decreased expression of PRB1 mRNA

NCBI chr 4:167,240,337...167,243,803
Ensembl chr 4:167,240,337...167,243,803

G

PR/SET domain 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PRDM10 mRNA

NCBI chr 8:37,982,210...38,085,907
Ensembl chr 8:37,982,403...38,085,907

G

PR/SET domain 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PRDM6 mRNA

NCBI chr18:49,102,290...49,206,763
Ensembl chr18:49,102,641...49,206,761

G

peroxiredoxin 1

affects binding

ISO

PRDX1 protein binds to Zinc

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 2

increases expression

EXP

Zinc deficiency results in increased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

proline and arginine rich end leucine rich repeat protein

increases expression

ISO

Zinc deficiency results in increased expression of PRELP mRNA

NCBI chr13:47,920,480...47,943,547
Ensembl chr13:47,922,590...47,932,324

G

protein kinase AMP-activated non-catalytic subunit beta 2

decreases expression

ISO

Zinc deficiency results in decreased expression of PRKAB2 mRNA

NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608

G

protein kinase C, alpha

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PRKCA mRNA
calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]

PMID:18593933 PMID:18652891

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

multiple interactions

ISO

Zinc promotes the reaction [FCER1A protein affects the localization of PRKCB protein]; Zinc promotes the reaction [OPRM1 protein binds to PRKCB protein]
PRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]

PMID:16495082 PMID:16818790 PMID:18652891

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, epsilon

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PRKCE mRNA

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, gamma

multiple interactions

ISO

[Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; calphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; calphostin complex inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; RGS17 protein affects the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Zinc inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]; Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]; Zinc promotes the reaction [RAF1 protein binds to PRKCG protein binds to HINT1 protein]

PMID:18652891 PMID:21235400

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814

G

protein kinase D2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PRKD2 mRNA

NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:86,642,629...86,670,675

G

protein kinase cGMP-dependent 2

increases expression

ISO

Zinc deficiency results in increased expression of PRKG2 mRNA

NCBI chr14:10,864,020...10,972,617
Ensembl chr14:10,864,186...10,972,614

G

protein kinase cAMP-dependent X-linked catalytic subunit

increases expression

EXP

Zinc deficiency results in increased expression of PRKX mRNA

NCBI chr X:45,701,747...45,745,210
Ensembl chr X:45,701,747...45,745,066

G

prolactin

increases expression
decreases expression

EXP
ISO

Zinc deficiency results in increased expression of PRL protein
Zinc results in decreased expression of PRL protein

PMID:15173390 PMID:19595304

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prolactin receptor

decreases expression
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of PRLR mRNA
Zinc promotes the reaction [GH1 protein binds to PRLR protein]

PMID:12915731 PMID:15173390

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

prion protein

affects localization
decreases response to substance

ISO

PRNP protein affects the localization of Zinc
PRNP protein results in decreased susceptibility to Zinc

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436

G

pre-mRNA processing factor 38A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PRPF38A mRNA

NCBI chr 5:128,541,166...128,552,865
Ensembl chr 5:128,541,166...128,552,865

G

phosphoribosyl pyrophosphate synthetase-associated protein 2

increases expression

EXP

Zinc results in increased expression of PRPSAP2 mRNA

NCBI chr10:46,910,282...46,945,401
Ensembl chr10:46,910,285...46,945,331

G

proline rich 11

increases expression

ISO

Zinc deficiency results in increased expression of PRR11 mRNA

NCBI chr10:72,396,127...72,440,643
Ensembl chr10:72,398,667...72,418,275

G

proline rich 5 like

decreases expression

ISO

Zinc deficiency results in decreased expression of PRR5L mRNA

NCBI chr 3:108,458,107...108,628,552
Ensembl chr 3:108,458,633...108,537,763

G

proline rich 9

increases expression

ISO

Zinc deficiency results in increased expression of PRR9 mRNA

NCBI chr 2:180,295,095...180,296,461
Ensembl chr 2:180,295,095...180,296,461

G

serine protease 35

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of PRSS35 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of PRSS35 mRNA]

NCBI chr 8:96,594,460...96,610,992
Ensembl chr 8:96,590,571...96,613,024

G

serine protease 8

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA

NCBI chr 1:191,966,701...191,971,271
Ensembl chr 1:191,966,701...191,971,193

G

phosphoserine aminotransferase 1

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of PSAT1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of PSAT1 mRNA]

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

presenilin 1

increases uptake

ISO

PSEN1 protein results in increased uptake of Zinc

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189

G

proteasome 26S subunit, ATPase 3

decreases expression

EXP

Zinc deficiency results in decreased expression of PSMC3 mRNA

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

EXP

Zinc affects the expression of PSMD4 mRNA

NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:185,286,868...185,297,201

G

proteasome activator subunit 3

decreases expression

EXP

Zinc deficiency results in decreased expression of PSME3 mRNA

NCBI chr10:86,757,933...86,765,719
Ensembl chr10:86,757,899...86,818,033

G

phosphoserine phosphatase

affects binding

ISO

PSPH protein binds to Zinc

NCBI chr12:32,527,091...32,541,182
Ensembl chr12:32,519,269...32,541,180

G

phosphatase and tensin homolog

multiple interactions
increases degradation

ISO

PTEN protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; PTEN protein inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]
Zinc results in increased degradation of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin D2 receptor

decreases expression

ISO

Zinc deficiency results in decreased expression of PTGDR mRNA

NCBI chr15:19,790,499...19,797,873
Ensembl chr15:19,790,499...19,797,873

G

prostaglandin E receptor 2

decreases expression

ISO

Zinc deficiency results in decreased expression of PTGER2 mRNA

NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950

G

prostaglandin E synthase

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of PTGES mRNA; Zinc deficiency results in increased expression of PTGES protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of PTGES mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of PTGES protein]

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin E synthase 2

increases expression

ISO

Zinc results in increased expression of PTGES2 mRNA

NCBI chr 3:36,088,246...36,095,430
Ensembl chr 3:36,088,246...36,097,694

G

prostaglandin-endoperoxide synthase 1

increases expression

ISO

Zinc deficiency results in increased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions
decreases response to substance

EXP
ISO

Zinc deficiency results in increased expression of PTGS2 mRNA; Zinc deficiency results in increased expression of PTGS2 protein; Zinc results in increased expression of PTGS2 protein
[Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of LTA4H protein; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of AGER protein]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of CCND1 protein]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of RELA protein modified form]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 mRNA]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 protein]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 mRNA]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 protein]; Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide]; Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to nitrosobenzylmethylamine]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of AGER protein]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of CCND1 protein]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of RELA protein modified form]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 mRNA]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 protein]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 mRNA]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 protein]]
PTGS2 protein results in decreased susceptibility to Zinc deficiency
Zinc inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of PTGS2 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of PTGS2 protein]
Zinc results in increased expression of PTGS2 mRNA; Zinc results in increased expression of PTGS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTGS2 mRNA; AG 1879 inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; AKT1 protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; PTEN protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; Zinc results in increased expression of and results in decreased degradation of PTGS2 mRNA

PMID:15632379 PMID:15980035 PMID:16140947 PMID:16584753 PMID:16979875 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2 beta

increases expression

ISO

Zinc deficiency results in increased expression of PTK2B mRNA

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

prothymosin alpha

decreases expression

EXP

Zinc deficiency results in decreased expression of PTMA mRNA

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions
decreases activity

ISO

[Zinc co-treated with pyrithione] results in decreased activity of PTPN1 protein
Zinc results in decreased activity of PTPN1 protein

PMID:14644152 PMID:22374166

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

G

protein tyrosine phosphatase, non-receptor type 22

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PTPN22 mRNA

NCBI chr 2:194,055,165...194,103,209
Ensembl chr 2:194,045,746...194,103,209

G

protein tyrosine phosphatase, receptor type, D

increases expression

EXP

Zinc results in increased expression of PTPRD mRNA

NCBI chr 5:95,093,221...97,415,498
Ensembl chr 5:95,095,858...96,178,903

G

protein tyrosine phosphatase, receptor type, H

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PTPRH mRNA

NCBI chr 1:78,272,414...78,318,977
Ensembl chr 1:78,271,276...78,318,977

G

protein tyrosine phosphatase, receptor type, N

increases expression

ISO

Zinc results in increased expression of PTPRN mRNA

NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:84,189,676...84,204,850

G

protein tyrosine phosphatase, receptor type N2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTPRN2 mRNA

NCBI chr 6:143,582,568...144,334,573
Ensembl chr 6:143,582,547...144,336,744

G

6-pyruvoyl-tetrahydropterin synthase

decreases expression

ISO

Zinc results in decreased expression of PTS mRNA

NCBI chr 8:59,767,234...59,774,265
Ensembl chr 8:59,765,185...59,774,265

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTTG1 protein]

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

pentraxin 3

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

purine rich element binding protein A

decreases expression

ISO

Zinc deficiency results in decreased expression of PURA mRNA

NCBI chr18:28,159,103...28,179,539
Ensembl chr18:28,125,126...28,211,111

G

purine rich element binding protein B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PURB mRNA

NCBI chr14:85,556,296...85,558,779
Ensembl chr14:85,550,417...85,572,205

G

PWWP domain containing 3A, DNA repair factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of PWWP3A mRNA

NCBI chr 7:10,115,865...10,132,696
Ensembl chr 7:10,115,866...10,130,925

G

PX domain containing serine/threonine kinase like

increases expression

EXP

Zinc results in increased expression of PXK mRNA

NCBI chr15:19,190,085...19,258,711
Ensembl chr15:19,190,085...19,258,671

G

pyrroline-5-carboxylate reductase 2

decreases expression

ISO

Zinc results in decreased expression of PYCR2 protein

NCBI chr13:95,158,236...95,162,030
Ensembl chr13:95,158,183...95,162,029

G

glycogen phosphorylase, muscle associated

decreases expression

EXP

Zinc deficiency results in decreased expression of PYGM mRNA

NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:213,119,791...213,134,612

G

pygopus family PHD finger 1

decreases expression

ISO

Zinc deficiency results in decreased expression of PYGO1 mRNA

NCBI chr 8:82,546,866...82,565,526
Ensembl chr 8:82,546,848...82,565,523

G

quiescin sulfhydryl oxidase 1

increases expression

EXP

Zinc deficiency results in increased expression of QSOX1 mRNA

NCBI chr13:70,500,060...70,537,711
Ensembl chr13:70,500,060...70,537,733

G

RAB11a, member RAS oncogene family

decreases expression

ISO

Zinc deficiency results in decreased expression of RAB11A mRNA

NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:74,118,922...74,141,837

G

RAB1A, member RAS oncogene family

decreases expression

EXP

Zinc deficiency results in decreased expression of RAB1A mRNA

NCBI chr14:98,623,582...98,648,766
Ensembl chr14:98,623,635...98,661,582

G

RAB21, member RAS oncogene family

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RAB21 mRNA

NCBI chr 7:52,790,158...52,814,943
Ensembl chr 7:52,790,165...52,814,943

G

RAB22A, member RAS oncogene family

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RAB22A mRNA

NCBI chr 3:182,877,746...182,924,400
Ensembl chr 3:182,877,998...182,924,400

G

RAB27B, member RAS oncogene family

decreases expression

ISO

Zinc deficiency results in decreased expression of RAB27B mRNA

NCBI chr18:65,870,230...66,069,597
Ensembl chr18:65,876,342...66,067,700

G

RAB3A, member RAS oncogene family

multiple interactions
increases expression

EXP
ISO

[MT3 protein binds to RAB3A protein] which results in decreased susceptibility to Zinc
Zinc deficiency results in increased expression of RAB3A mRNA

PMID:15039103 PMID:18356318

NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842

G

RAB3A interacting protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RAB3IP mRNA

NCBI chr 7:54,417,418...54,461,253
Ensembl chr 7:54,418,358...54,447,000

G

RAB7A, member RAS oncogene family

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RAB7A mRNA

NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185

G

rabaptin, RAB GTPase binding effector protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RABEP1 mRNA

NCBI chr10:56,064,742...56,168,778
Ensembl chr10:56,064,753...56,166,177

G

RAD18 E3 ubiquitin protein ligase

multiple interactions
affects binding

ISO

sodium arsenite inhibits the reaction [Zinc binds to RAD18 protein]

NCBI chr 4:147,291,463...147,376,904
Ensembl chr 4:147,291,276...147,376,869

G

RAD23 homolog B, nucleotide excision repair protein

increases expression

ISO

Zinc deficiency results in increased expression of RAD23B mRNA

NCBI chr 5:74,885,518...74,923,621
Ensembl chr 5:74,885,516...74,962,426

G

RAD54 like

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RAD54L mRNA

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:134,811,532...134,841,425

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

calphostin complex inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Zinc inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]; Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]; Zinc promotes the reaction [RAF1 protein binds to PRKCG protein binds to HINT1 protein]

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

ral guanine nucleotide dissociation stimulator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RALGDS mRNA

NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:32,237,786...32,278,045

G

RAN GTPase activating protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RANGAP1 mRNA

NCBI chr 7:115,104,820...115,130,564
Ensembl chr 7:115,104,823...115,130,564

G

Rap guanine nucleotide exchange factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RAPGEF2 mRNA

NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698

G

retinoic acid receptor, alpha

increases expression
multiple interactions

ISO

Zinc deficiency results in increased expression of RARA mRNA; Zinc results in increased expression of RARA protein mutant form
[PCI 5002 co-treated with Zinc] results in increased expression of RARA mRNA

PMID:16330433 PMID:18593933 PMID:22171008

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

retinoic acid receptor responder 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RARRES1 mRNA

NCBI chr 2:154,059,761...154,094,021
Ensembl chr 2:154,059,761...154,094,024

G

ras related dexamethasone induced 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RAS guanyl releasing protein 1

affects expression

ISO

Zinc affects the expression of RASGRP1 mRNA

NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434

G

Ras interacting protein 1

decreases expression

ISO

Zinc deficiency results in decreased expression of RASIP1 mRNA

NCBI chr 1:105,233,599...105,246,028
Ensembl chr 1:105,233,599...105,246,028

G

Ras association domain family member 1

increases expression

ISO

Zinc results in increased expression of RASSF1 mRNA

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

RB transcriptional corepressor 1

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RB binding protein 6, ubiquitin ligase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RBBP6 mRNA

NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852

G

RNA binding fox-1 homolog 3

multiple interactions

EXP

Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of RBFOX3 protein]

NCBI chr10:104,218,940...104,655,863
Ensembl chr10:104,218,940...104,551,945

G

RNA binding motif protein 15

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RBM15 mRNA

NCBI chr 2:197,634,174...197,642,697
Ensembl chr 2:197,583,002...197,643,037

G

RNA binding motif protein 22

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RBM22 mRNA

NCBI chr18:56,283,807...56,294,615
Ensembl chr18:56,283,770...56,295,073

G

RNA binding motif protein 25

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RBM25 mRNA
Zinc deficiency results in increased expression of RBM25 mRNA

PMID:18593933 PMID:20857495

NCBI chr 6:108,993,119...109,050,159
Ensembl chr 6:109,002,869...109,050,159

G

RNA binding motif protein 39

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of RBM39 mRNA

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

RNA binding motif, single stranded interacting protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RBMS1 mRNA

NCBI chr 3:65,604,475...65,829,072
Ensembl chr 3:65,606,358...65,829,013

G

ring finger and CCCH-type domains 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RC3H1 mRNA

NCBI chr13:75,707,098...75,779,114
Ensembl chr13:75,707,338...75,772,816

G

regulator of calcineurin 1

multiple interactions
decreases response to substance

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RCAN1 mRNA
RCAN1 protein results in decreased susceptibility to Zinc

PMID:17596961 PMID:18593933

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236

G

regulator of chromosome condensation 2

increases expression

ISO

Zinc deficiency results in increased expression of RCC2 mRNA

NCBI chr 5:158,277,476...158,300,294
Ensembl chr 5:158,277,476...158,300,294

G

reticulocalbin 2

decreases expression

ISO

Zinc deficiency results in decreased expression of RCN2 mRNA

NCBI chr 8:65,345,247...65,362,290
Ensembl chr 8:65,345,273...65,364,632

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization
increases expression
decreases expression
decreases activity

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of RELA mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in decreased activity of RELA protein]; Zinc inhibits the reaction [TNF protein affects the localization of RELA protein]; Zinc inhibits the reaction [TNF protein results in increased activity of RELA protein]; Zinc results in decreased localization of and results in decreased activity of RELA protein
Zinc affects the localization of RELA protein
Zinc deficiency results in increased expression of RELA protein
[Thymic Factor, Circulating co-treated with Zinc] results in increased activity of RELA protein; Paraquat promotes the reaction [Zinc affects the localization of RELA protein]; Zinc inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of RELA protein]; Zinc promotes the reaction [Paraquat affects the localization of RELA protein]
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of RELA protein; [Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of RELA mRNA]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of RELA protein modified form]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of RELA protein modified form]]
Zinc results in decreased expression of RELA protein

PMID:12429649 PMID:12639846 PMID:16472982 PMID:16606632 PMID:16818790 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

ring finger and WD repeat domain 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RFWD3 mRNA

NCBI chr19:56,145,221...56,177,871
Ensembl chr19:56,145,221...56,177,815

G

regulatory factor X3

increases expression

ISO

Zinc deficiency results in increased expression of RFX3 mRNA

NCBI chr 1:234,863,462...235,122,989
Ensembl chr 1:234,863,462...235,122,536

G

regulatory factor X4

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RFX4 mRNA

NCBI chr 7:20,740,760...20,903,355
Ensembl chr 7:20,741,079...20,902,851

G

regulator of cell cycle

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RGCC mRNA

NCBI chr15:61,071,574...61,084,408
Ensembl chr15:61,071,574...61,084,408

G

regulator of G-protein signaling 11

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RGS11 mRNA

NCBI chr10:15,727,279...15,735,536
Ensembl chr10:15,727,279...15,735,536

G

regulator of G-protein signaling 12

increases expression

ISO

Zinc deficiency results in increased expression of RGS12 mRNA

NCBI chr14:79,940,561...80,048,637
Ensembl chr14:79,940,565...80,034,859

G

regulator of G-protein signaling 13

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RGS13 mRNA

NCBI chr13:58,472,604...58,505,922
Ensembl chr13:58,472,604...58,505,922

G

regulator of G-protein signaling 16

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RGS16 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RGS16 mRNA

PMID:18593933 PMID:33549593

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

regulator of G-protein signaling 17

multiple interactions

ISO

RGS17 protein affects the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Zinc promotes the reaction [OPRM1 protein binds to RGS17 protein]

NCBI chr 1:44,627,583...44,729,957
Ensembl chr 1:44,632,964...44,729,945

G

regulator of G-protein signaling 18

decreases expression

ISO

Zinc deficiency results in decreased expression of RGS18 mRNA

NCBI chr13:59,043,431...59,066,342
Ensembl chr13:59,043,431...59,066,342

G

regulator of G-protein signaling 19

decreases expression

EXP

Zinc results in decreased expression of RGS19 mRNA

NCBI chr 3:189,182,041...189,190,494
Ensembl chr 3:189,182,383...189,190,736

G

regulator of G-protein signaling 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

regulator of G-protein signaling 20

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RGS20 mRNA

NCBI chr 5:19,282,249...19,412,122
Ensembl chr 5:19,282,153...19,413,286

G

Ras homolog, mTORC1 binding

decreases expression

ISO

Zinc deficiency results in decreased expression of RHEB mRNA

PMID:18356318 PMID:22171008

NCBI chr 4:11,012,173...11,053,860
Ensembl chr 4:11,012,643...11,053,931

G

ras homolog family member B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

Rho-related BTB domain containing 1

decreases expression

EXP

Zinc deficiency results in decreased expression of RHOBTB1 protein

NCBI chr20:19,326,197...19,455,182
Ensembl chr20:19,326,212...19,402,057

G

ras homolog family member F, filopodia associated

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RHOF mRNA

NCBI chr12:39,082,413...39,107,528
Ensembl chr12:39,091,979...39,107,528

G

ras homolog family member U

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RHOU mRNA

NCBI chr19:68,538,960...68,548,733
Ensembl chr19:68,538,960...68,548,733

G

ras homolog family member V

multiple interactions
increases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in increased expression of RHOV mRNA]

NCBI chr 3:126,714,608...126,723,617
Ensembl chr 3:126,714,610...126,723,739

G

rhophilin, Rho GTPase binding protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RHPN2 mRNA

NCBI chr 1:97,128,054...97,188,803
Ensembl chr 1:97,127,697...97,188,803

G

RIC8 guanine nucleotide exchange factor B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RIC8B mRNA

NCBI chr 7:20,636,337...20,730,066
Ensembl chr 7:20,636,687...20,730,178

G

RIO kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RIOK3 mRNA

NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,602,535...3,628,108

G

receptor-interacting serine-threonine kinase 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RIPK4 mRNA

NCBI chr11:50,591,926...50,614,169
Ensembl chr11:50,591,936...50,614,169

G

ring finger protein, LIM domain interacting

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RLIM mRNA

NCBI chr X:73,048,983...73,070,302
Ensembl chr X:73,054,098...73,069,992

G

required for meiotic nuclear division 5 homolog A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RMND5A mRNA

NCBI chr 4:104,934,160...104,991,088
Ensembl chr 4:104,934,160...104,991,088

G

ribonuclease A family member 4

decreases expression

ISO

Zinc results in decreased expression of RNASE4 mRNA

NCBI chr15:26,786,287...26,803,634
Ensembl chr15:26,786,079...26,803,639

G

ribonuclease L

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of RNASEL mRNA

NCBI chr13:68,446,641...68,460,804
Ensembl chr13:68,446,882...68,459,557

G

Rho family GTPase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

Rho family GTPase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536

G

ring finger protein 138

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RNF138 mRNA

NCBI chr18:12,558,430...12,590,849
Ensembl chr18:12,566,502...12,590,848

G

ring finger protein 216

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RNF216 mRNA

NCBI chr12:16,568,327...16,689,868
Ensembl chr12:16,568,347...16,690,989

G

ring finger protein 5

increases expression

ISO

Zinc deficiency results in increased expression of RNF5 mRNA

NCBI chr20:4,150,032...4,152,593
Ensembl chr20:4,150,138...4,152,591

G

Ro60, Y RNA binding protein

decreases expression

ISO

Zinc results in decreased expression of RO60 mRNA

NCBI chr13:58,049,838...58,070,828
Ensembl chr13:58,049,858...58,076,264

G

RAR-related orphan receptor B

decreases expression

ISO

Zinc deficiency results in decreased expression of RORB mRNA

NCBI chr 1:225,790,216...225,970,973
Ensembl chr 1:225,790,216...225,970,973

G

replication protein A2

decreases expression

ISO

Zinc deficiency results in decreased expression of RPA2 mRNA

NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:150,260,723...150,271,546

G

ribose 5-phosphate isomerase A

decreases expression

ISO

Zinc results in decreased expression of RPIA protein

NCBI chr 4:104,282,081...104,307,732
Ensembl chr 4:104,282,081...104,307,718

G

ribosomal protein L35

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RPL35 mRNA

NCBI chr 3:43,162,960...43,166,485
Ensembl chr 3:43,162,764...43,165,947

G

ribosomal protein L36A like 1

decreases expression

EXP

Zinc deficiency results in decreased expression of RPL36AL mRNA

NCBI chr 6:93,390,864...93,392,258
Ensembl chr 6:93,390,866...93,391,296
Ensembl chr20:93,390,866...93,391,296

G

ribosomal protein L37A

decreases expression

ISO

Zinc deficiency results in decreased expression of RPL37A mRNA

NCBI chr 9:81,748,091...81,750,174
Ensembl chr 9:81,748,103...81,751,975

G

ribosomal protein L38

decreases expression

ISO

Zinc deficiency results in decreased expression of RPL38 mRNA

NCBI chr10:100,200,414...100,204,070
Ensembl chr16:10,188,932...10,189,144
Ensembl chr 2:10,188,932...10,189,144
Ensembl chr 3:10,188,932...10,189,144
Ensembl chr14:10,188,932...10,189,144
Ensembl chr10:10,188,932...10,189,144

G

ribosomal protein L5

decreases expression

ISO

Zinc deficiency results in decreased expression of RPL5 mRNA

NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225

G

ribosomal protein S10

decreases expression

ISO

Zinc deficiency results in decreased expression of RPS10 mRNA

NCBI chr20:5,696,135...5,700,863
Ensembl chr20:5,696,135...5,700,150
Ensembl chr 6:5,696,135...5,700,150

G

ribosomal protein S13

decreases expression

ISO

Zinc deficiency results in decreased expression of RPS13 mRNA

NCBI chr 1:180,007,230...180,009,660
Ensembl chr 1:180,002,471...180,009,660

G

ribosomal protein S19

decreases expression

ISO

Zinc deficiency results in decreased expression of RPS19 mRNA

NCBI chr 1:89,608,408...89,614,390
Ensembl chr 7:104,324,520...104,325,132
Ensembl chr 1:104,324,520...104,325,132

G

ribosomal protein SA

increases expression

ISO

Zinc deficiency results in increased expression of RPSA mRNA

NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737

G

ribosome binding protein 1

decreases expression
increases expression

ISO

Zinc deficiency results in decreased expression of RRBP1 mRNA
Zinc deficiency results in increased expression of RRBP1 mRNA

PMID:18356318 PMID:22171008

NCBI chr 3:151,768,386...151,830,255
Ensembl chr 3:151,768,386...151,830,255

G

ras responsive element binding protein 1

affects expression

ISO

Zinc affects the expression of RREB1 mRNA

NCBI chr17:27,082,217...27,208,061
Ensembl chr17:27,082,227...27,208,061

G

ribonucleotide reductase regulatory subunit M2

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

round spermatid basic protein 1-like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RSBN1L mRNA

NCBI chr 4:15,014,405...15,093,287
Ensembl chr 4:15,031,173...15,093,286

G

ribosomal L1 domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RSL1D1 mRNA

NCBI chr10:4,931,839...4,943,726
Ensembl chr10:4,904,792...4,946,566

G

arginine and serine rich coiled-coil 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RSRC2 mRNA

NCBI chr12:38,500,709...38,520,715
Ensembl chr12:38,500,770...38,520,707

G

arginine and serine rich protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RSRP1 mRNA

NCBI chr 5:152,431,448...152,435,202
Ensembl chr 5:152,431,478...152,435,126

G

RT1 class Ib, locus M3, gene 1

increases expression

ISO

Zinc deficiency results in increased expression of HLA-G mRNA

NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366

G

RUN domain containing 3B

increases expression

ISO

Zinc deficiency results in increased expression of RUNDC3B mRNA

NCBI chr 4:26,417,501...26,554,404
Ensembl chr 4:26,417,437...26,554,403

G

RUNX1 partner transcriptional co-repressor 1

increases expression

ISO

Zinc deficiency results in increased expression of RUNX1T1 mRNA

NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:31,984,855...32,132,855

G

RUNX family transcription factor 2

decreases expression

EXP

Zinc deficiency results in decreased expression of RUNX2 mRNA; Zinc deficiency results in decreased expression of RUNX2 protein

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

RING1 and YY1 binding protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of RYBP mRNA

NCBI chr 4:134,432,663...134,484,732
Ensembl chr 4:134,432,663...134,484,930

G

ryanodine receptor 1

decreases expression

EXP

Zinc deficiency results in decreased expression of RYR1 mRNA

NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305

G

S100 calcium binding protein A13

decreases expression

ISO

Zinc deficiency results in decreased expression of S100A13 mRNA

NCBI chr 2:178,297,020...178,303,514
Ensembl chr 2:178,296,917...178,303,507

G

S100 calcium binding protein A2

affects binding
multiple interactions

ISO

Zinc binds to S100A2 protein
[PCI 5002 co-treated with Zinc] results in increased expression of S100A2 mRNA; [Zinc binds to S100A2 protein] inhibits the reaction [Calcium binds to S100A2 protein]

PMID:17239974 PMID:18593933

NCBI chr 2:178,374,659...178,375,903

G

S100 calcium binding protein A5

decreases expression

ISO

Zinc deficiency results in decreased expression of S100A5 mRNA

NCBI chr 2:178,392,922...178,397,128
Ensembl chr 2:178,395,121...178,397,128

G

S100 calcium binding protein A8

multiple interactions
increases expression
affects binding

ISO
EXP

[Zinc co-treated with Calcium] binds to [S100A8 protein binds to S100A9 protein]
Zinc deficiency results in increased expression of S100A8 mRNA; Zinc deficiency results in increased expression of S100A8 protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of S100A8 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of S100A8 protein]
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of S100A8 mRNA; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 mRNA]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 protein]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 mRNA]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A8 protein]]
Zinc binds to [S100A8 protein binds to S100A9 protein]

PMID:17050004 PMID:19111725 PMID:20857495 PMID:22689922 PMID:33549593

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

S100 calcium binding protein A9

affects binding
increases expression
multiple interactions

ISO
EXP

Zinc binds to [S100A8 protein binds to S100A9 protein]
Zinc deficiency results in increased expression of S100A9 mRNA; Zinc deficiency results in increased expression of S100A9 protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of S100A9 mRNA]
PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 mRNA]; PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 protein]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 mRNA]]; Zinc inhibits the reaction [PTGS2 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of S100A9 protein]]
[Zinc co-treated with Calcium] binds to [S100A8 protein binds to S100A9 protein]

PMID:17050004 PMID:19111725 PMID:20857495 PMID:22689922

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

spalt-like transcription factor 1

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of SALL1 mRNA

NCBI chr19:34,179,316...34,196,278
Ensembl chr19:34,181,078...34,196,278

G

sterile alpha motif domain containing 4A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SAMD4A mRNA

NCBI chr15:22,616,200...22,831,872
Ensembl chr15:22,614,287...22,831,872

G

sterile alpha motif domain containing 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SAMD8 mRNA

NCBI chr15:2,561,435...2,611,702
Ensembl chr15:2,561,435...2,607,052

G

SAM domain, SH3 domain and nuclear localization signals, 1

increases expression

ISO

Zinc deficiency results in increased expression of SAMSN1 mRNA

NCBI chr11:27,971,565...28,021,944
Ensembl chr11:27,970,564...28,021,944

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SAMTOR mRNA

NCBI chr 4:42,847,720...42,911,546
Ensembl chr 4:42,836,172...42,917,567

G

Sin3A associated protein 30

increases expression

ISO

Zinc deficiency results in increased expression of SAP30 mRNA

NCBI chr16:37,758,494...37,763,825
Ensembl chr16:37,757,656...37,763,823

G

sarcosine dehydrogenase

decreases expression

ISO

Zinc deficiency results in decreased expression of SARDH mRNA

NCBI chr 3:30,908,621...30,973,409
Ensembl chr 3:30,908,621...30,972,137

G

strawberry notch homolog 1

increases expression

ISO

Zinc results in increased expression of SBNO1 mRNA

NCBI chr12:37,835,306...37,895,861
Ensembl chr12:37,846,514...37,891,231

G

scavenger receptor class A, member 3

decreases expression

ISO

Zinc results in decreased expression of SCARA3 mRNA

NCBI chr15:44,315,422...44,348,416
Ensembl chr15:44,315,422...44,348,551

G

stearoyl-CoA desaturase

multiple interactions
increases expression
affects expression

ISO
EXP

[Zinc deficiency co-treated with Ethanol] affects the expression of SCD1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of SCD1 mRNA]
Zinc deficiency results in increased expression of SCD mRNA; Zinc deficiency results in increased expression of SCD1 mRNA
Zinc deficiency affects the expression of SCD1 mRNA

PMID:16140947 PMID:19111725 PMID:24155903

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

stearoyl-Coenzyme A desaturase 2

increases expression

ISO

Zinc deficiency results in increased expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

sec1 family domain containing 2

decreases expression

ISO

Zinc results in decreased expression of SCFD2 mRNA

NCBI chr14:34,037,392...34,369,423
Ensembl chr14:34,037,430...34,363,436

G

secretoglobin family 1A member 1

multiple interactions
increases expression

EXP

Zinc inhibits the reaction [Zinc deficiency results in increased expression of SCGB1A1 mRNA]

NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:215,406,138...215,409,686

G

schwannomin interacting protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SCHIP1 mRNA

NCBI chr 2:154,437,217...155,198,560
Ensembl chr 2:155,060,798...155,198,557

G

Scm polycomb group protein like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SCML1 mRNA

NCBI chr X:36,526,068...36,543,336
Ensembl chr X:36,526,068...36,544,450

G

sodium voltage-gated channel alpha subunit 1

increases expression

EXP

Zinc results in increased expression of SCN1A mRNA

NCBI chr 3:71,360,840...71,479,870
Ensembl chr 3:71,360,841...71,479,791

G

syndecan 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SDC4 mRNA

NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670

G

stromal cell-derived factor 2-like 1

increases expression

ISO

Zinc deficiency results in increased expression of SDF2L1 mRNA

NCBI chr11:97,376,878...97,379,120
Ensembl chr11:97,376,878...97,379,120

G

stromal cell derived factor 4

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of SDF4 mRNA

NCBI chr 5:171,868,591...171,885,827
Ensembl chr 5:171,868,563...171,888,884

G

serine dehydratase

decreases expression

EXP

Zinc deficiency results in decreased expression of SDS mRNA

NCBI chr12:41,743,796...41,751,108
Ensembl chr12:41,743,799...41,748,773

G

SEC13 homolog, nuclear pore and COPII coat complex component

increases expression

ISO

Zinc deficiency results in increased expression of SEC13 mRNA

NCBI chr 4:148,433,344...148,446,735
Ensembl chr 4:148,433,349...148,446,755

G

Sec23 homolog B, COPII coat complex component

increases expression

ISO

Zinc deficiency results in increased expression of SEC23B mRNA

NCBI chr 3:152,392,340...152,434,813
Ensembl chr 3:152,392,308...152,434,800

G

SEC24 homolog A, COPII coat complex component

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SEC24A mRNA

NCBI chr10:36,450,043...36,525,303
Ensembl chr10:36,450,043...36,525,303

G

SEC61 translocon subunit alpha 1

increases expression

ISO

Zinc deficiency results in increased expression of SEC61A1 mRNA

NCBI chr 4:122,530,785...122,545,141
Ensembl chr 4:122,530,789...122,545,141

G

secreted and transmembrane 1B

increases expression

EXP

Zinc deficiency results in increased expression of SECTM1 mRNA

NCBI chr10:106,822,397...106,832,105
Ensembl chr10:106,822,397...106,832,104

G

selenium binding protein 1

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of SELENBP1 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of SELENBP1 mRNA]

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:185,183,004...185,194,295

G

selenoprotein I

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SELENOI mRNA

NCBI chr 6:31,792,972...31,831,170
Ensembl chr 6:31,792,973...31,831,523

G

selenoprotein P

affects binding

ISO

SELENOP protein binds to Zinc

NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:54,225,152...54,236,019

G

selenoprotein W

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SELENOW mRNA

NCBI chr 1:85,727,631...85,732,703
Ensembl chr 1:85,727,632...85,732,703

G

semaphorin 3E

increases expression

ISO

Zinc deficiency results in increased expression of SEMA3E mRNA

NCBI chr 4:21,252,686...21,510,449
Ensembl chr 4:21,210,734...21,510,374

G

semaphorin 4A

increases expression

ISO

Zinc deficiency results in increased expression of SEMA4A mRNA

NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:176,194,255...176,212,258

G

semaphorin 4B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SEMA4B mRNA

NCBI chr 1:143,545,727...143,587,037
Ensembl chr 1:143,537,690...143,587,037

G

semenogelin 1

multiple interactions
affects transport
affects binding

ISO

SEMG1 protein inhibits the reaction [Zinc results in decreased activity of KLK5 protein]
SEMG1 protein affects the transport of Zinc
Zinc binds to SEMG1 protein

PMID:16517595 PMID:16582407 PMID:17253191

NCBI chr 3:173,329,413...173,332,261
Ensembl chr 3:173,329,414...173,332,261

G

SUMO specific peptidase 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SENP5 mRNA

NCBI chr11:82,289,680...82,324,545
Ensembl chr11:82,289,648...82,324,542

G

SUMO specific peptidase 7

decreases expression

ISO

Zinc deficiency results in decreased expression of SENP7 mRNA

NCBI chr11:57,892,801...58,053,213
Ensembl chr11:57,787,914...58,033,766

G

serine hydrolase-like 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SERHL2 mRNA

NCBI chr 7:116,126,085...116,146,345
Ensembl chr 7:116,126,085...116,152,765

G

serpin family A member 1

affects binding

ISO

SERPINA1 protein binds to Zinc

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703

G

serpin family A member 3N

affects binding

ISO

SERPINA3 protein binds to Zinc

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family A member 4

affects binding

ISO

SERPINA4 protein binds to Zinc

NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028

G

serpin family A member 5

multiple interactions

ISO

Zinc affects the reaction [SEMG2 protein binds to SERPINA5 protein]

NCBI chr 6:128,774,006...128,793,187
Ensembl chr 6:128,784,991...128,793,186

G

serpin family A member 6

affects binding

ISO

SERPINA6 protein binds to Zinc

NCBI chr 6:128,544,828...128,555,064
Ensembl chr 6:128,544,831...128,555,139

G

serpin family B member 2

decreases expression
multiple interactions
increases expression

ISO
EXP

Zinc results in decreased expression of SERPINB2 mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of SERPINB2 mRNA]

PMID:16140947 PMID:18316168

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031

G

serpin family B member 3

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of SERPINB3 mRNA; Zinc deficiency results in increased expression of SERPINB3 protein
Zinc inhibits the reaction [Zinc deficiency results in increased expression of SERPINB3 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SERPINB3 protein]

NCBI chr13:23,788,758...23,795,298
Ensembl chr13:23,788,758...23,795,298

G

serpin family B member 8

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SERPINB8 mRNA
Zinc results in decreased expression of SERPINB8 mRNA

PMID:18316168 PMID:18593933

NCBI chr13:24,141,557...24,164,894
Ensembl chr13:24,129,855...24,166,076

G

serpin family B member 9

decreases expression

ISO

Zinc results in decreased expression of SERPINB9 mRNA

NCBI chr17:31,628,887...31,652,003
Ensembl chr17:31,629,392...31,651,974

G

serpin family D member 1

affects binding

ISO

SERPIND1 protein binds to Zinc

NCBI chr11:97,168,753...97,179,830
Ensembl chr11:97,168,754...97,179,755

G

serpin family E member 1

multiple interactions

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of SERPINE1 mRNA
Zinc inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]

PMID:18593933 PMID:19369054

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serpin family E member 2

decreases expression

ISO

Zinc deficiency results in decreased expression of SERPINE2 mRNA

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202

G

serpin family H member 1

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SERPINH1 mRNA
Zinc results in decreased expression of SERPINH1 protein

PMID:15984569 PMID:18593933

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

SERTA domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001

G

SERTA domain containing 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SERTAD3 mRNA

NCBI chr 1:91,891,141...91,894,861
Ensembl chr 1:91,893,616...91,897,110

G

sestrin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

SET domain and mariner transposase fusion gene

decreases expression

ISO

Zinc deficiency results in decreased expression of SETMAR mRNA

NCBI chr 4:142,602,066...142,614,208
Ensembl chr 4:142,602,088...142,614,206

G

senataxin

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SETX mRNA

NCBI chr 3:32,825,771...32,878,740
Ensembl chr 3:32,828,412...32,878,740

G

seizure related 6 homolog like

decreases expression

ISO

Zinc deficiency results in decreased expression of SEZ6L mRNA

NCBI chr12:49,725,330...49,882,222
Ensembl chr12:49,725,330...49,882,222

G

stratifin

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SFN mRNA

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995

G

surfactant protein C

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of SFTPC mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of SFTPC mRNA]

NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475

G

sarcoglycan, delta

increases expression

ISO

Zinc deficiency results in increased expression of SGCD mRNA

NCBI chr10:31,847,713...32,829,554
Ensembl chr10:31,781,748...32,419,064

G

sphingomyelin synthase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SGMS1 mRNA

NCBI chr 1:239,409,991...239,681,195
Ensembl chr 1:239,409,991...239,505,774

G

sphingomyelin synthase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SGMS2 mRNA

NCBI chr 2:222,567,661...222,641,804
Ensembl chr 2:222,567,664...222,590,807

G

SH3 domain and tetratricopeptide repeats 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SH3TC1 mRNA

NCBI chr14:79,230,322...79,274,622
Ensembl chr14:79,230,371...79,274,620

G

SH3 and multiple ankyrin repeat domains 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SHANK2 mRNA

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736

G

SH3 and multiple ankyrin repeat domains 3

affects folding
affects binding

EXP

Zinc affects the folding of SHANK3 protein
Zinc binds to SHANK3 protein

NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:122,448,323...122,510,410

G

SH2 domain containing adaptor protein B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SHB mRNA

NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:64,473,694...64,581,072

G

sex hormone binding globulin

affects binding

ISO

SHBG protein binds to Zinc

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

serine hydroxymethyltransferase 1

increases expression

ISO

Zinc deficiency results in increased expression of SHMT1 mRNA

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,960,434...45,997,326

G

siah E3 ubiquitin protein ligase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873

G

sialic acid binding Ig-like lectin 5

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SIGLEC6 mRNA

NCBI chr 1:102,904,705...102,913,281
Ensembl chr 1:102,904,578...102,913,281

G

salt-inducible kinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

salt-inducible kinase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SIK2 mRNA

NCBI chr 8:60,121,913...60,221,707
Ensembl chr 8:60,121,913...60,221,818

G

SIK family kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SIK3 mRNA

NCBI chr 8:55,208,969...55,419,138
Ensembl chr 8:55,208,815...55,419,138

G

SIL1 nucleotide exchange factor

increases expression

ISO

Zinc deficiency results in increased expression of SIL1 mRNA

NCBI chr18:27,146,526...27,378,459
Ensembl chr18:27,146,527...27,307,693

G

sirtuin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

SIVA1, apoptosis-inducing factor

affects binding

ISO

Zinc binds to SIVA1 protein

NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790

G

SKI-like proto-oncogene

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SKIL mRNA

NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:114,175,534...114,201,974

G

solute carrier family 10 member 1

decreases expression

EXP

Zinc deficiency results in decreased expression of SLC10A1 mRNA

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier family 11 member 2

increases expression
decreases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of SLC11A2 mRNA; Zinc results in increased expression of SLC11A2 protein
Zinc deficiency results in decreased expression of SLC11A2 mRNA
[IFNG protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc; [Lipopolysaccharides results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc; [TNF protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc; Zinc inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]

PMID:16614402 PMID:18073202 PMID:19306086 PMID:22736759

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

solute carrier family 12 member 4

increases expression

ISO

Zinc deficiency results in increased expression of SLC12A4 mRNA

NCBI chr19:50,748,268...50,770,217
Ensembl chr19:50,748,279...50,770,259

G

solute carrier family 12 member 5

multiple interactions
increases activity

EXP

botulinum toxin type C analog inhibits the reaction [Zinc results in increased activity of SLC12A5 protein]; Calcium affects the reaction [Zinc results in increased activity of SLC12A5 protein]

NCBI chr 3:174,115,833...174,155,112
Ensembl chr 3:174,115,833...174,155,112

G

solute carrier family 12, member 9

increases expression

ISO

Zinc deficiency results in increased expression of SLC12A9 mRNA

NCBI chr12:25,005,741...25,022,628
Ensembl chr12:25,005,738...25,022,607

G

solute carrier family 13 member 1

increases expression

ISO

Zinc deficiency results in increased expression of SLC13A1 mRNA

NCBI chr 4:53,534,763...53,612,704
Ensembl chr 4:53,534,768...53,612,704

G

solute carrier family 14 member 2

increases expression

ISO

Zinc results in increased expression of SLC14A2 mRNA

Ensembl chr18:73,887,575...73,953,570

G

solute carrier family 15 member 1

decreases expression
decreases activity
multiple interactions

EXP
ISO

Zinc deficiency results in decreased expression of SLC15A1 mRNA
Zinc results in decreased activity of SLC15A1 protein
[Zinc inhibits the reaction [JBP 485 binds to SLC15A1 protein]] which results in decreased uptake of JBP 485; [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of ceftibuten; [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of Cephradine; [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of glycylsarcosine; Zinc inhibits the reaction [JBP 485 binds to SLC15A1 protein]
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of SLC15A1 mRNA]

PMID:14567632 PMID:19111725 PMID:21712612

NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369

G

solute carrier family 16 member 3

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC16A3 protein]

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 17 member 7

multiple interactions
increases uptake

EXP

bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]; bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]]; SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 18 member A2

decreases expression
multiple interactions

EXP

Zinc results in decreased expression of SLC18A2 protein
Paraquat promotes the reaction [Zinc results in decreased expression of SLC18A2 protein]; Zinc promotes the reaction [Paraquat results in decreased expression of SLC18A2 protein]

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 1

multiple interactions
affects transport

ISO

Acetylcysteine affects the reaction [SLC1A1 protein affects the transport of Zinc]

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469

G

solute carrier family 1 member 2

increases expression

EXP

Zinc deficiency results in increased expression of SLC1A2 protein

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 1 member 4

increases expression

ISO

Zinc deficiency results in increased expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 20 member 1

decreases expression
multiple interactions

EXP
ISO

Zinc results in decreased expression of SLC20A1 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of SLC20A1 mRNA

PMID:17074742 PMID:18593933

NCBI chr 3:136,880,360...136,894,255
Ensembl chr 3:136,880,290...136,894,249

G

solute carrier family 23 member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC23A2 mRNA

NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343

G

solute carrier family 25 member 17

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC25A17 mRNA

NCBI chr 7:114,724,533...114,767,163
Ensembl chr 7:114,724,533...114,767,345

G

solute carrier family 25 member 25

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC25A25 mRNA

NCBI chr 3:36,106,448...36,139,812
Ensembl chr 3:36,106,449...36,140,011

G

solute carrier family 25, member 30

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SLC25A30 mRNA

NCBI chr15:57,486,346...57,508,981
Ensembl chr15:57,486,350...57,502,690

G

solute carrier family 25 member 33

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC25A33 mRNA

NCBI chr 5:165,478,070...165,518,186
Ensembl chr 5:165,478,072...165,502,973

G

solute carrier family 25 member 37

increases expression

ISO

Zinc deficiency results in increased expression of SLC25A37 mRNA

NCBI chr15:50,944,085...50,986,506
Ensembl chr15:50,946,236...50,986,808

G

solute carrier family 25, member 44

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC25A44 mRNA

NCBI chr 2:176,166,136...176,180,965
Ensembl chr 2:176,166,139...176,180,838

G

solute carrier family 25, member 51

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC25A51 mRNA

NCBI chr 5:64,445,610...64,459,172
Ensembl chr 5:64,443,616...64,459,462

G

solute carrier family 27 member 1

decreases expression

EXP

Zinc deficiency results in decreased expression of SLC27A1 mRNA

PMID:12672911 PMID:15671213

NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,313,015...18,330,045

G

solute carrier family 27 member 5

decreases expression
increases expression

ISO
EXP

Zinc deficiency results in decreased expression of SLC27A5 mRNA
Zinc deficiency results in increased expression of SLC27A5 mRNA

PMID:12672911 PMID:22171008

NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358

G

solute carrier family 29 member 2

increases expression

ISO

Zinc deficiency results in increased expression of SLC29A2 mRNA

NCBI chr 1:211,756,588...211,764,561
Ensembl chr 1:211,757,000...211,764,560

G

solute carrier family 2 member 1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 2

multiple interactions

EXP

Zinc inhibits the reaction [Streptozocin results in increased expression of SLC2A2 protein]

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 2 member 5

increases expression

ISO
EXP

Zinc deficiency results in increased expression of SLC2A5 mRNA

PMID:11717422 PMID:22171008

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038

G

solute carrier family 30 member 1

affects expression
increases expression
increases uptake
decreases expression
affects localization
decreases response to substance
affects transport
multiple interactions
decreases uptake
increases transport

EXP
ISO

Zinc affects the expression of SLC30A1 mRNA
Zinc results in increased expression of SLC30A1 mRNA; Zinc results in increased expression of SLC30A1 protein
SLC30A1 protein results in increased uptake of Zinc
Zinc deficiency results in decreased expression of SLC30A1 protein
Zinc affects the localization of SLC30A1 protein
SLC30A1 mRNA results in decreased susceptibility to Zinc; SLC30A1 protein results in decreased susceptibility to Zinc; SLC30A1 results in decreased susceptibility to Zinc
SLC30A1 protein affects the transport of Zinc
Pentetic Acid affects the reaction [SLC30A1 protein affects the transport of Zinc]; SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; SLC30A1 protein promotes the reaction [[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]
Zinc deficiency results in decreased expression of SLC30A1; Zinc deficiency results in decreased expression of SLC30A1 protein
Zinc deficiency results in decreased expression of SLC30A1 mRNA; Zinc results in decreased expression of SLC30A1 mRNA; Zinc results in decreased expression of SLC30A1 protein
Zinc results in increased expression of SLC30A1; Zinc results in increased expression of SLC30A1 mRNA
SLC30A1 protein results in decreased uptake of Zinc
[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; [MT1 protein co-treated with MT2 protein] promotes the reaction [SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; SLC30A1 inhibits the reaction [Zinc results in increased expression of and results in increased secretion of CLU protein]
SLC30A1 protein results in increased transport of Zinc
[PCI 5002 co-treated with Zinc] results in increased expression of SLC30A1 mRNA; [Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; [Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SLC30A1 mRNA; Zinc inhibits the reaction [ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]]; Zinc results in increased expression of and affects the localization of SLC30A1 protein

PMID:7882967 PMID:9254680 PMID:12421840 PMID:14568174 PMID:15041749 More...

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 30, member 10

affects abundance
decreases expression
multiple interactions
decreases response to substance

EXP
ISO

SLC30A10 protein affects the abundance of Zinc
Zinc results in decreased expression of SLC30A10 mRNA
[SLC30A10 protein affects the abundance of Zinc] which affects the expression of CDKN1A protein; [SLC30A10 protein affects the abundance of Zinc] which affects the expression of TP53 protein
SLC30A10 protein results in decreased susceptibility to Zinc

NCBI chr13:99,529,664...99,584,442
Ensembl chr13:99,529,790...99,544,213

G

solute carrier family 30 member 2

decreases secretion
increases expression
decreases expression
increases export
affects localization
multiple interactions
increases abundance
increases secretion
increases transport

ISO
EXP

SLC30A2 protein mutant form results in decreased secretion of Zinc
Zinc deficiency results in increased expression of SLC30A2 protein; Zinc results in increased expression of SLC30A2 mRNA
Zinc deficiency results in decreased expression of SLC30A2 mRNA
SLC30A2 protein results in increased export of Zinc
SLC30A2 protein affects the localization of Zinc
[Zinc deficiency co-treated with Vitamin A deficiency] results in increased expression of SLC30A2 mRNA; SLC30A2 protein affects the localization of and results in increased export of Zinc
Zinc deficiency results in decreased expression of SLC30A2; Zinc deficiency results in decreased expression of SLC30A2 protein
[Dexamethasone results in increased expression of SLC30A2] which results in decreased abundance of Zinc; Zinc promotes the reaction [MTF1 protein results in increased expression of SLC30A2 mRNA]
SLC30A2 protein results in increased abundance of Zinc
SLC30A2 protein results in increased secretion of Zinc
SLC30A2 protein results in increased transport of Zinc

PMID:11717422 PMID:12421840 PMID:17065149 PMID:17074742 PMID:17349999 More...

NCBI chr 5:151,843,451...151,855,674
Ensembl chr 5:151,843,389...151,855,670

G

solute carrier family 30 member 3

increases transport
multiple interactions
affects secretion
decreases expression
affects abundance
increases abundance

ISO
EXP

SLC30A3 protein results in increased transport of Zinc
SLC30A3 gene mutant form inhibits the reaction [Estradiol results in decreased abundance of Zinc]
SLC30A3 protein affects the secretion of Zinc
Zinc results in decreased expression of SLC30A3 mRNA
SLC30A3 protein affects the abundance of Zinc
SLC30A3 protein results in increased abundance of Zinc
[Fatty Acids, Omega-3 affects the expression of SLC30A3 protein] which affects the metabolism of Zinc; [SLC30A3 protein affects the abundance of Zinc] which affects the expression of CDKN1A protein; [SLC30A3 protein affects the abundance of Zinc] which affects the expression of TP53 protein; bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]]; SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]

PMID:14681234 PMID:15860731 PMID:15883362 PMID:17349999 PMID:17949919 More...

NCBI chr 6:30,984,241...31,004,689
Ensembl chr 6:30,984,276...31,005,120

G

solute carrier family 30 member 4

increases transport
decreases expression
increases expression

ISO
EXP

SLC30A4 protein results in increased transport of Zinc
Zinc deficiency results in decreased expression of SLC30A4 mRNA
Zinc deficiency results in increased expression of SLC30A4 mRNA; Zinc deficiency results in increased expression of SLC30A4 protein

PMID:12421840 PMID:18326752 PMID:22171008

NCBI chr 3:130,206,852...130,228,888
Ensembl chr 3:130,206,852...130,228,888

G

solute carrier family 30 member 5

increases transport
increases response to substance
decreases expression
increases uptake
multiple interactions

ISO

SLC30A5 protein results in increased transport of Zinc
SLC30A5 protein results in increased susceptibility to Zinc
Zinc deficiency results in decreased expression of SLC30A5 mRNA; Zinc results in decreased expression of SLC30A5 mRNA; Zinc results in decreased expression of SLC30A5 protein
SLC30A5 protein results in increased uptake of Zinc
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC30A5 mRNA

PMID:11904301 PMID:15753530 PMID:17234632 PMID:18326752 PMID:19720134 More...

NCBI chr 2:33,679,800...33,710,025
Ensembl chr 2:33,679,800...33,712,596

G

solute carrier family 30 member 6

increases transport
multiple interactions

ISO

SLC30A6 protein results in increased transport of Zinc
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of SLC30A6 mRNA

PMID:18326752 PMID:19720134

NCBI chr 6:26,772,804...26,802,656
Ensembl chr 6:26,772,804...26,802,656

G

solute carrier family 30 member 7

increases transport
decreases expression
multiple interactions
increases expression

ISO

SLC30A7 protein results in increased transport of Zinc
Zinc results in decreased expression of SLC30A7 mRNA
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc] results in decreased expression of SLC30A7 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of SLC30A7 mRNA
Zinc results in increased expression of SLC30A7 mRNA

PMID:17085522 PMID:18326752 PMID:19071009 PMID:19720134

NCBI chr 2:206,544,800...206,607,087
Ensembl chr 2:206,544,800...206,607,043

G

solute carrier family 30 member 8

increases abundance
affects uptake
affects localization
increases uptake
increases transport

ISO
EXP

SLC30A8 protein results in increased abundance of Zinc
SLC30A8 protein affects the uptake of Zinc
SLC30A8 protein affects the localization of Zinc
SLC30A8 protein results in increased uptake of Zinc
SLC30A8 protein results in increased transport of Zinc

PMID:15331542 PMID:16984975 PMID:18326752 PMID:19479076

NCBI chr 7:85,481,864...85,517,255
Ensembl chr 7:85,481,864...85,517,177

G

solute carrier family 30 member 9

increases transport

ISO

SLC30A9 protein results in increased transport of Zinc

NCBI chr14:41,170,164...41,224,861
Ensembl chr14:41,170,166...41,224,788

G

solute carrier family 31 member 1

multiple interactions

EXP

Zinc inhibits the reaction [SLC31A1 protein results in increased import of Copper]

NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809

G

solute carrier family 33 member 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC33A1 mRNA

NCBI chr 2:150,565,327...150,587,700
Ensembl chr 2:150,565,328...150,587,416

G

solute carrier family 35 member A2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC35A2 mRNA

NCBI chr X:17,280,072...17,288,928
Ensembl chr X:17,280,074...17,288,613

G

solute carrier family 35, member A5

increases expression

ISO

Zinc deficiency results in increased expression of SLC35A5 mRNA

NCBI chr11:69,159,435...69,180,503
Ensembl chr11:69,159,384...69,180,502

G

solute carrier family 35, member B1

increases expression

ISO

Zinc deficiency results in increased expression of SLC35B1 mRNA

NCBI chr10:80,824,972...80,832,048
Ensembl chr10:80,824,696...80,832,045

G

solute carrier family 38, member 10

increases expression

ISO

Zinc deficiency results in increased expression of SLC38A10 mRNA

NCBI chr10:105,885,250...105,935,043
Ensembl chr10:105,885,250...105,935,043

G

solute carrier family 38, member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 1

increases transport
increases uptake
multiple interactions
affects expression
affects metabolic processing
decreases expression

ISO

SLC39A1 protein results in increased transport of Zinc
SLC39A1 protein results in increased uptake of Zinc
Cadmium Chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]; cobaltous chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]; ferrous chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]; nickel chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc]
Zinc deficiency promotes the reaction [ochratoxin A results in decreased expression of SLC39A1 mRNA]
Zinc affects the expression of SLC39A1 mRNA
SLC39A1 protein affects the metabolism of Zinc
Zinc results in decreased expression of SLC39A1 mRNA

PMID:11301334 PMID:12888280 PMID:14525987 PMID:15226459 PMID:15322118 More...

NCBI chr 2:178,001,052...178,006,689
Ensembl chr 2:178,001,119...178,006,689

G

solute carrier family 39 member 10

increases transport
increases expression
decreases expression
multiple interactions
increases uptake

ISO
EXP

SLC39A10 protein results in increased transport of Zinc
Zinc deficiency results in increased expression of SLC39A10 mRNA; Zinc deficiency results in increased expression of SLC39A10 protein
Zinc results in decreased expression of SLC39A10 mRNA
MTF1 mutant form inhibits the reaction [Zinc results in decreased expression of SLC39A10 mRNA]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A10 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A10 protein]; Zinc promotes the reaction [MTF1 protein binds to SLC39A10 promoter]
[ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC39A10 mRNA; [PCI 5002 co-treated with Zinc] results in increased expression of SLC39A10 mRNA; [Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A10 mRNA
Zinc results in increased expression of SLC39A10 mRNA; Zinc results in increased expression of SLC39A10 protein
SLC39A10 protein results in increased uptake of Zinc
Zinc results in decreased expression of SLC39A10 mRNA; Zinc results in decreased expression of SLC39A10 protein
Cadmium inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]; Dicyclohexylcarbodiimide inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]; Iodoacetates inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]; Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]

PMID:16804107 PMID:18326752 PMID:18593933 PMID:18936201 PMID:19720134 More...

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:62,370,598...62,454,747

G

solute carrier family 39, member 11

increases transport

ISO

SLC39A11 protein results in increased transport of Zinc

NCBI chr10:98,775,155...99,196,302
Ensembl chr10:98,776,525...99,107,368

G

solute carrier family 39 member 12

increases transport

ISO

SLC39A12 protein results in increased transport of Zinc

NCBI chr17:82,262,303...82,348,974
Ensembl chr17:82,262,351...82,349,229

G

solute carrier family 39 member 13

increases transport
affects localization
increases expression
multiple interactions

ISO
EXP

SLC39A13 protein results in increased transport of Zinc
SLC39A13 protein affects the localization of Zinc
Zinc deficiency results in increased expression of SLC39A13 mRNA
Zinc results in increased expression of SLC39A13 mRNA
[[Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC39A13 promoter]] which results in increased expression of SLC39A13 mRNA; [Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC39A13 promoter]; [Zinc deficiency promotes the reaction [NFIC protein binds to SLC39A13 protein]] which results in decreased expression of SLC39A13 mRNA; Zinc deficiency promotes the reaction [NFIC protein binds to SLC39A13 protein]

PMID:18326752 PMID:18985159 PMID:20859692 PMID:22228435

NCBI chr 3:97,495,229...97,504,279
Ensembl chr 3:97,495,229...97,505,052

G

solute carrier family 39 member 14

affects import
increases import
increases uptake
affects expression
increases transport

ISO

SLC39A14 protein affects the import of Zinc
SLC39A14 protein results in increased import of Zinc
SLC39A14 protein results in increased uptake of Zinc
Zinc affects the expression of SLC39A14 mRNA
SLC39A14 protein results in increased transport of Zinc

PMID:15794747 PMID:15863613 PMID:16950869 PMID:17085522 PMID:18326752 More...

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229

G

solute carrier family 39 member 2

increases transport
increases uptake
increases expression

ISO
EXP

SLC39A2 protein results in increased transport of Zinc
SLC39A2 protein results in increased uptake of Zinc
Zinc results in increased expression of SLC39A2 mRNA

PMID:14525987 PMID:15322118 PMID:17028381 PMID:18326752

NCBI chr15:27,063,699...27,066,349
Ensembl chr15:27,064,237...27,066,349

G

solute carrier family 39 member 3

increases transport
increases uptake
affects expression
decreases expression
affects metabolic processing

ISO

SLC39A3 protein results in increased transport of Zinc
SLC39A3 protein results in increased uptake of Zinc
Zinc affects the expression of SLC39A3 mRNA
Zinc deficiency results in decreased expression of SLC39A3 mRNA; Zinc results in decreased expression of SLC39A3 mRNA
SLC39A3 protein affects the metabolism of Zinc

PMID:14525987 PMID:15322118 PMID:16434472 PMID:16652366 PMID:17085522 More...

NCBI chr 7:9,327,541...9,333,542
Ensembl chr 7:9,327,455...9,335,845

G

solute carrier family 39 member 4

multiple interactions
increases expression
affects localization
increases response to substance
increases uptake
decreases expression
affects expression
increases transport

ISO

Ammonium Chloride inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; methyl-beta-cyclodextrin inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; Sucrose inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; Zinc results in increased ubiquitination of and results in increased degradation of SLC39A4 protein
Zinc deficiency results in increased expression of SLC39A4 mRNA; Zinc deficiency results in increased expression of SLC39A4 protein
Zinc affects the localization of SLC39A4 protein; Zinc deficiency affects the localization of SLC39A4 protein
SLC39A4 gene mutant form results in increased susceptibility to Zinc deficiency
SLC39A4 protein results in increased uptake of Zinc
Zinc results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 protein
Cycloheximide inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Cycloheximide inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA]; Zinc affects the localization of and results in increased degradation of SLC39A4 protein; Zinc deficiency results in increased expression of and results in increased stability of SLC39A4 mRNA; Zinc inhibits the reaction [Zinc deficiency results in increased expression of and results in increased stability of SLC39A4 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 protein]
Zinc affects the expression of SLC39A4 protein
Zinc deficiency results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 protein
Zinc affects the expression of SLC39A4 mRNA
SLC39A4 protein results in increased transport of Zinc

PMID:12514265 PMID:12801924 PMID:14709598 PMID:15322118 PMID:15358787 More...

NCBI chr 7:110,214,017...110,218,202
Ensembl chr 7:110,214,017...110,218,202

G

solute carrier family 39 member 5

increases transport
increases expression
decreases expression
increases uptake
affects localization

ISO

SLC39A5 protein results in increased transport of Zinc
Zinc results in increased expression of SLC39A5 protein
Zinc deficiency results in decreased expression of SLC39A5 protein
SLC39A5 protein results in increased uptake of Zinc
Zinc affects the localization of SLC39A5 protein; Zinc deficiency affects the localization of SLC39A5 protein
Zinc results in decreased expression of SLC39A5 mRNA

PMID:15322118 PMID:15358787 PMID:18020946 PMID:18326752 PMID:19071009

NCBI chr 7:1,409,360...1,415,407
Ensembl chr 7:1,409,360...1,414,784

G

solute carrier family 39 member 6

increases transport
increases expression
affects uptake
multiple interactions
increases uptake
affects expression
decreases expression

ISO
EXP

SLC39A6 protein results in increased transport of Zinc
Zinc deficiency results in increased expression of SLC39A6 protein
SLC39A6 protein affects the uptake of Zinc
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]]
SLC39A6 protein results in increased uptake of Zinc
Zinc affects the expression of SLC39A6 mRNA
Zinc results in decreased expression of SLC39A6 mRNA
SLC39A6 protein inhibits the reaction [Lipopolysaccharides results in decreased abundance of Zinc]

PMID:12839489 PMID:15867272 PMID:16892068 PMID:17085522 PMID:18272141 More...

NCBI chr18:16,139,621...16,160,163
Ensembl chr18:16,135,008...16,160,163

G

solute carrier family 39 member 7

increases transport
affects localization
increases phosphorylation
multiple interactions
decreases expression
increases expression

ISO

SLC39A7 protein results in increased transport of Zinc
SLC39A7 protein affects the localization of Zinc
Zinc results in increased phosphorylation of SLC39A7 protein
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Zinc results in increased phosphorylation of SLC39A7 protein]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]]; [Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]; SLC39A7 mutant form inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Zinc promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]
Zinc deficiency results in decreased expression of SLC39A7 mRNA; Zinc results in decreased expression of SLC39A7 mRNA; Zinc results in decreased expression of SLC39A7 protein
Zinc results in increased expression of SLC39A7 mRNA

PMID:15705588 PMID:17085522 PMID:18326752 PMID:18583420 PMID:19071009 More...

NCBI chr20:4,824,967...4,828,431
Ensembl chr20:4,824,688...4,828,430

G

solute carrier family 39 member 8

increases transport
increases uptake
multiple interactions
increases expression
increases import
decreases expression

ISO
EXP

SLC39A8 protein results in increased transport of Zinc
SLC39A8 protein results in increased uptake of Zinc
Bicarbonates affects the reaction [SLC39A8 protein results in increased uptake of Zinc]; Cadmium inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Cobalt inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Copper inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Iron inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Nickel inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]
Zinc results in increased expression of SLC39A8 protein
Iron inhibits the reaction [SLC39A8 protein results in increased import of Zinc]; Zinc inhibits the reaction [SLC39A8 protein results in increased import of Iron]
[TNF protein results in increased expression of SLC39A8 protein] which results in increased import of Zinc
Zinc deficiency results in decreased expression of SLC39A8 mRNA
Zinc results in decreased expression of SLC39A8 mRNA

PMID:17085522 PMID:18326752 PMID:18390834 PMID:20859692 PMID:22898811 More...

NCBI chr 2:226,845,686...226,992,668
Ensembl chr 2:226,929,644...226,992,667

G

solute carrier family 39, member 9

increases transport
decreases expression

ISO

SLC39A9 protein results in increased transport of Zinc
Zinc results in decreased expression of SLC39A9 mRNA

PMID:18326752 PMID:19071009

NCBI chr 6:106,022,858...106,061,734
Ensembl chr 6:106,022,850...106,071,176

G

solute carrier family 3 member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 40 member 1

decreases expression
multiple interactions
increases expression

EXP
ISO

Zinc results in decreased expression of SLC40A1 protein
MTF1 mutant form inhibits the reaction [Zinc results in increased expression of SLC40A1 mRNA]
Zinc results in increased expression of SLC40A1 protein

PMID:16614402 PMID:20688958

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier family 48 member 1

increases expression

ISO

Zinc results in increased expression of SLC48A1 mRNA

NCBI chr 7:130,794,233...130,802,119
Ensembl chr 7:130,794,245...130,803,022

G

solute carrier family 5 member 1

multiple interactions
decreases expression

ISO

Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]; Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]
Zinc results in decreased expression of SLC5A1 mRNA

PMID:9512726 PMID:20073493

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 5 member 10

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC5A10 mRNA

NCBI chr10:46,851,527...46,898,460
Ensembl chr10:46,851,527...46,899,277

G

solute carrier family 66 member 3

decreases expression

ISO

Zinc deficiency results in decreased expression of SLC66A3 mRNA

NCBI chr 6:45,503,541...45,515,293
Ensembl chr 6:45,503,545...45,515,117

G

solute carrier family 6 member 13

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC6A13 mRNA

NCBI chr 4:156,211,381...156,248,491
Ensembl chr 4:156,211,462...156,248,489

G

solute carrier family 6 member 3

multiple interactions
increases expression
decreases activity

ISO
EXP

[Amphetamine co-treated with Zinc] results in decreased localization of SLC6A3 protein
Zinc results in increased expression of SLC6A3 protein
Paraquat promotes the reaction [Zinc results in increased expression of SLC6A3 protein]; Zinc promotes the reaction [Paraquat results in increased expression of SLC6A3 protein]
Zinc results in decreased activity of SLC6A3 protein

PMID:16684900 PMID:32060784

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 6 member 4

increases expression
multiple interactions
decreases expression

EXP

Zinc deficiency results in increased expression of SLC6A4 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of SLC6A4 mRNA]

PMID:16140947 PMID:16413754

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

solute carrier family 7 member 11

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier family 9 member A3

decreases expression

EXP

Zinc deficiency results in decreased expression of SLC9A3 mRNA

NCBI chr 1:30,953,215...30,996,209
Ensembl chr 1:30,953,216...30,996,002

G

solute carrier organic anion transporter family, member 1c1

increases expression

ISO

Zinc results in increased expression of SLCO1C1 mRNA

NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:176,197,741...176,244,395

G

schlafen family member 4

decreases expression

ISO

Zinc deficiency results in decreased expression of SLFN12 mRNA

NCBI chr10:68,492,135...68,515,674
Ensembl chr10:68,508,916...68,513,991

G

slit guidance ligand 3

decreases expression

ISO

Zinc deficiency results in decreased expression of SLIT3 mRNA

NCBI chr10:20,075,929...20,660,704
Ensembl chr10:20,076,021...20,660,704

G

sarcolipin

decreases expression

EXP

Zinc deficiency results in decreased expression of SLN mRNA

NCBI chr 8:63,117,577...63,144,290
Ensembl chr 8:63,139,722...63,143,971

G

SLU7 homolog, splicing factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SLU7 mRNA

NCBI chr10:28,406,908...28,425,253
Ensembl chr10:28,409,846...28,425,250

G

SLX4 structure-specific endonuclease subunit

increases expression

ISO

Zinc deficiency results in increased expression of SLX4 mRNA

NCBI chr10:12,032,131...12,055,685
Ensembl chr10:12,033,048...12,055,650

G

SMAD family member 1

increases phosphorylation

ISO

Zinc results in increased phosphorylation of SMAD1 protein

NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957

G

SMAD family member 2

multiple interactions

ISO

Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein]; Zinc results in increased stability of and results in increased activity of SMAD2 protein

PMID:22228435 PMID:26354774

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SMAD family member 3

multiple interactions

ISO

Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; Zinc promotes the reaction [SMAD3 protein modified form binds to SMAD2 protein modified form binds to NFIC protein]; Zinc results in increased stability of and results in increased activity of SMAD3 protein

PMID:22228435 PMID:26354774

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 6

increases expression

ISO

Zinc deficiency results in increased expression of SMAD6 mRNA

NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:73,345,460...73,414,149

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SMARCA4 mRNA

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:28,443,810...28,535,070

G

SWI/SNF related BAF chromatin remodeling complex subunit E1

decreases expression

ISO

Zinc deficiency results in decreased expression of SMARCE1 mRNA

NCBI chr10:84,655,468...84,678,259
Ensembl chr10:84,655,468...84,676,185

G

small integral membrane protein 26

decreases expression

ISO

Zinc deficiency results in decreased expression of SMIM26 mRNA

NCBI chr 3:152,443,397...152,445,102
Ensembl chr 3:152,443,579...152,445,447

G

smoothened, frizzled class receptor

increases expression

ISO

Zinc results in increased expression of SMO mRNA

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

spermine oxidase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SMOX mRNA

NCBI chr 3:139,184,793...139,220,174
Ensembl chr 3:139,184,798...139,220,170
Ensembl chr X:139,184,798...139,220,170

G

small muscle protein, X-linked

decreases expression

EXP

Zinc deficiency results in decreased expression of SMPX mRNA

NCBI chr X:41,049,354...41,107,323
Ensembl chr X:41,049,356...41,107,137

G

SMAD specific E3 ubiquitin protein ligase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SMURF1 mRNA

NCBI chr12:14,748,717...14,840,273
Ensembl chr12:14,749,043...14,840,273

G

SMAD specific E3 ubiquitin protein ligase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SMURF2 mRNA

NCBI chr10:92,261,516...92,362,185
Ensembl chr10:92,261,525...92,362,552

G

SET and MYND domain containing 2

decreases expression

ISO

Zinc deficiency results in decreased expression of SMYD2 mRNA

NCBI chr13:103,956,470...103,997,774
Ensembl chr13:103,956,473...103,997,774

G

snail family transcriptional repressor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SNAI1 mRNA

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

affects binding
multiple interactions

EXP
ISO

Zinc binds to SNAI2 protein
[PCI 5002 co-treated with Zinc] results in increased expression of SNAI2 mRNA

PMID:18593933 PMID:18761175

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synaptosome associated protein 25

multiple interactions

ISO

Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]
[PCI 5002 co-treated with Zinc] results in decreased expression of SNAP25 mRNA

PMID:11181932 PMID:18593933

NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448

G

Smad nuclear interacting protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SNIP1 mRNA

NCBI chr 5:142,613,028...142,620,502
Ensembl chr 5:142,613,004...142,620,527

G

small nucleolar RNA, H/ACA box 50C

decreases expression

ISO

Zinc deficiency results in decreased expression of SNORA50C mRNA

NCBI chr10:91,935,331...91,935,463
Ensembl chr10:91,935,331...91,935,463

G

small nucleolar RNA, C/D box 21

decreases expression

ISO

Zinc deficiency results in decreased expression of SNORD21 mRNA

NCBI chr14:1,992,069...1,992,162
Ensembl chr14:1,992,069...1,992,162

G

SNF related kinase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SNRK mRNA

NCBI chr 8:130,657,204...130,711,461
Ensembl chr 8:130,657,266...130,711,457

G

small nuclear ribonucleoprotein polypeptide E

decreases expression

ISO

Zinc deficiency results in decreased expression of SNRPE mRNA

NCBI chr13:47,596,324...47,609,390
Ensembl chr 8:129,294,325...129,294,603
Ensembl chr13:129,294,325...129,294,603

G

suppressor of cytokine signaling 2

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SOCS2 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SOCS2 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SOCS2 mRNA
Zinc deficiency results in decreased expression of SOCS2 mRNA

PMID:16979875 PMID:18593933 PMID:22171008 PMID:33549593

NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423

G

suppressor of cytokine signaling 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

multiple interactions
affects folding
increases activity
affects binding
decreases activity
increases expression

ISO
EXP

[Copper co-treated with Cadmium co-treated with Zinc] results in decreased activity of SOD1 protein; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine binds to Zinc] inhibits the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]; [SOD1 protein mutant form inhibits the reaction [Zinc binds to SOD1 protein]] promotes the reaction [SOD1 protein mutant form binds to SOD1 protein]; Cadmium Chloride inhibits the reaction [Zinc binds to SOD1 protein]; Cadmium inhibits the reaction [Zinc binds to SOD1 protein]; SOD1 gene mutant form inhibits the reaction [Zinc binds to SOD1 protein]; SOD1 protein mutant form inhibits the reaction [SOD1 protein binds to Zinc]; SOD1 protein mutant form inhibits the reaction [Zinc binds to SOD1 protein]; Zinc binds to and affects the folding of and affects the stability of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]
Zinc affects the folding of SOD1 protein
[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein]; [Zinc deficiency co-treated with Ethanol] results in decreased expression of SOD1 protein
Zinc deficiency results in increased activity of SOD1 protein; Zinc results in increased activity of SOD1 protein
[Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of SOD1 protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of SOD1 protein]; [Zinc co-treated with Chromium] results in increased activity of SOD1 protein; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD1 protein]; [Zinc deficiency co-treated with Chromium] results in increased activity of SOD1 protein; Dexamethasone inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Thyroxine inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Zinc affects the reaction [sodium arsenite results in decreased activity of SOD1 protein]
Zinc binds to SOD1 mutant form; Zinc binds to SOD1 protein
Zinc deficiency results in decreased activity of SOD1 protein; Zinc results in decreased activity of SOD1 protein
Zinc results in increased expression of SOD1 mRNA

PMID:10381190 PMID:10938463 PMID:15076160 PMID:16413754 PMID:16440303 More...

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases expression
multiple interactions
decreases activity

EXP

Zinc deficiency results in increased expression of SOD2 mRNA
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD2 protein]; Zinc affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]
Zinc results in decreased activity of SOD2 protein

PMID:20128680 PMID:22127830 PMID:22534743 PMID:23859036 PMID:24184500

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sortilin related receptor 1

increases expression

ISO

Zinc deficiency results in increased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446

G

sortilin 1

increases expression

ISO

Zinc deficiency results in increased expression of SORT1 mRNA

NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481

G

SOS Ras/Rac guanine nucleotide exchange factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SOS1 mRNA

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

sosondowah ankyrin repeat domain family member C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SOWAHC mRNA

NCBI chr20:27,738,247...27,742,713
Ensembl chr20:27,736,326...27,752,912

G

SRY-box transcription factor 12

increases expression

ISO

Zinc results in increased expression of SOX12 mRNA

NCBI chr 3:161,319,800...161,320,819
Ensembl chr 3:161,298,764...161,326,428

G

SRY-box transcription factor 2

multiple interactions

EXP

Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOX2 protein]

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

SRY-box transcription factor 3

increases expression

ISO

Zinc results in increased expression of SOX3 mRNA

NCBI chr X:144,344,892...144,346,971
Ensembl chr X:144,344,892...144,346,987

G

SRY-box transcription factor 8

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SOX8 mRNA

NCBI chr10:15,089,357...15,094,345
Ensembl chr10:15,089,357...15,094,345

G

Sp1 transcription factor

multiple interactions
decreases expression
increases activity
affects binding

ISO
EXP

Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]; Cadmium inhibits the reaction [SP1 protein binds to Zinc]; Cadmium results in decreased activity of [SP1 protein binds to Zinc]; Zinc inhibits the reaction [Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter]]
Zinc deficiency results in decreased expression of SP1 protein
Zinc promotes the reaction [MTF1 protein binds to SP1 protein]; Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]]
Zinc deficiency results in increased activity of SP1 protein

PMID:18356318 PMID:18458062 PMID:20073493 PMID:21893222

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

Sp7 transcription factor

decreases expression

EXP

Zinc deficiency results in decreased expression of SP7 mRNA

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

sperm associated antigen 9

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPAG9 mRNA

NCBI chr10:79,440,311...79,574,709
Ensembl chr10:79,440,377...79,575,258

G

spermatogenesis associated 2-like

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPATA2L mRNA

NCBI chr19:68,177,599...68,182,122
Ensembl chr19:68,176,615...68,182,069

G

spermatogenesis associated, serine-rich 2

increases expression

ISO

Zinc deficiency results in increased expression of SPATS2 mRNA

NCBI chr 7:132,159,021...132,232,296
Ensembl chr 7:132,159,014...132,232,296

G

SPC24 component of NDC80 kinetochore complex

increases expression

ISO

Zinc deficiency results in increased expression of SPC24 mRNA

NCBI chr 8:28,576,409...28,581,481
Ensembl chr 8:28,576,409...28,581,299

G

signal peptidase complex subunit 2

increases expression

ISO

Zinc deficiency results in increased expression of SPCS2 mRNA

NCBI chr 1:163,575,842...163,595,269
Ensembl chr 1:163,575,842...163,595,271

G

spindle and centriole associated protein 1

decreases expression

ISO

Zinc results in decreased expression of SPICE1 mRNA

NCBI chr11:69,796,490...69,838,304
Ensembl chr11:69,795,884...69,838,266

G

spindlin interactor and repressor of chromatin binding

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPINDOC mRNA

NCBI chr 1:213,971,995...213,995,162
Ensembl chr 1:213,971,995...213,993,433

G

serine peptidase inhibitor, Kazal type 1

multiple interactions
increases expression

ISO
EXP

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of SPINK1 mRNA
Zinc deficiency results in increased expression of SPINK1 mRNA

PMID:11717422 PMID:12517797

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

serine peptidase inhibitor, Kazal type 4

decreases expression

ISO

Zinc results in decreased expression of SPINK4 mRNA

NCBI chr 5:60,811,899...60,860,823
Ensembl chr 5:60,849,060...60,860,823

G

spire-type actin nucleation factor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPIRE1 mRNA

NCBI chr18:63,311,800...63,441,545
Ensembl chr18:63,311,800...63,441,534

G

sialophorin

decreases expression

ISO

Zinc deficiency results in decreased expression of SPN mRNA

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852

G

spondin 1

decreases expression

ISO

Zinc results in decreased expression of SPON1 mRNA

NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:177,363,197...177,662,676

G

secreted phosphoprotein 1

multiple interactions
increases expression

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SPP1 mRNA
Zinc deficiency results in increased expression of SPP1 mRNA

PMID:16979875 PMID:20857495

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sprouty-related, EVH1 domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPRED2 mRNA

NCBI chr14:98,350,577...98,452,143
Ensembl chr14:98,350,290...98,452,143

G

small proline rich protein 2A

increases expression

ISO

Zinc deficiency results in increased expression of SPRR2H mRNA

NCBI chr 2:180,511,568...180,511,840

G

small proline rich protein 2F

increases expression

ISO

Zinc deficiency results in increased expression of SPRR2F mRNA

NCBI chr 2:180,685,587...180,685,817
Ensembl chr 2:180,685,587...180,685,817

G

sprouty RTK signaling antagonist 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPRY4 mRNA

NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,687,039...30,704,173

G

splA/ryanodine receptor domain and SOCS box containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPSB1 mRNA

NCBI chr 5:165,641,255...165,701,482
Ensembl chr 5:165,642,851...165,654,225

G

serine palmitoyltransferase, long chain base subunit 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPTLC2 mRNA

NCBI chr 6:112,679,623...112,762,470
Ensembl chr 6:112,679,623...112,762,640

G

SPT2 chromatin protein domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SPTY2D1 mRNA

NCBI chr 1:106,667,750...106,685,871
Ensembl chr 1:106,667,750...106,685,871

G

sequestosome 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases activity
multiple interactions
increases phosphorylation
increases expression

ISO

Zinc results in decreased activity of SRC protein
Zinc promotes the reaction [EGFR protein binds to SRC protein]; Zinc results in increased phosphorylation of and results in increased activity of SRC protein
Zinc results in increased phosphorylation of SRC protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased phosphorylation of SRC protein]
Zinc deficiency results in increased phosphorylation of SRC protein
Zinc deficiency results in increased expression of SRC mRNA

PMID:11983694 PMID:12915106 PMID:12972402 PMID:15980035 PMID:16410015 More...

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

steroid 5 alpha-reductase 1

increases expression

EXP

Zinc results in increased expression of SRD5A1 mRNA

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903

G

SRSF protein kinase 2

increases expression

ISO

Zinc deficiency results in increased expression of SRPK2 mRNA

NCBI chr 4:12,356,983...12,548,345
Ensembl chr 4:12,357,053...12,548,342

G

SRP receptor subunit alpha

increases expression

ISO

Zinc deficiency results in increased expression of SRPRA mRNA

NCBI chr 8:41,818,199...41,824,292
Ensembl chr 8:41,818,229...41,824,280

G

serine and arginine rich splicing factor 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SRSF5 mRNA

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

serine and arginine rich splicing factor 9

decreases expression

ISO

Zinc results in decreased expression of SRSF9 protein

NCBI chr12:46,938,948...46,945,213
Ensembl chr12:46,938,950...46,945,283

G

somatostatin

decreases expression
decreases secretion
increases expression

ISO
EXP

Zinc deficiency results in decreased expression of SST mRNA
Zinc deficiency results in decreased secretion of SST protein
Zinc deficiency results in increased expression of SST mRNA

PMID:11717422 PMID:11842894 PMID:18356318

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823

G

signal transducer and activator of transcription 1

multiple interactions

ISO
EXP

Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein]; Zinc deficiency affects the phosphorylation of and results in increased expression of STAT1 protein; Zinc deficiency results in decreased activity of and affects the localization of STAT1 protein

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of STAT2 mRNA

NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:1,287,024...1,303,459

G

signal transducer and activator of transcription 3

decreases activity
increases expression
decreases phosphorylation
multiple interactions

ISO
EXP

Zinc deficiency results in decreased activity of STAT3 protein
Zinc deficiency results in increased expression of STAT3 mRNA; Zinc results in increased expression of STAT3 mRNA
Zinc deficiency results in decreased phosphorylation of STAT3 protein
Zinc deficiency results in decreased phosphorylation of and affects the localization of STAT3 protein
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein]

PMID:28086195 PMID:31505237

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

signal transducer and activator of transcription 4

increases activity

ISO

Zinc deficiency results in increased activity of STAT4 protein

NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 6

increases expression

ISO

Zinc deficiency results in increased expression of STAT6 mRNA

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795

G

staufen double-stranded RNA binding protein 2

multiple interactions
decreases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of STAU2 mRNA
Zinc deficiency results in decreased expression of STAU2 protein

PMID:18593933 PMID:22689922

NCBI chr 5:7,623,528...7,868,206
Ensembl chr 5:7,624,019...7,868,204

G

stanniocalcin 2

decreases expression

ISO

Zinc deficiency results in decreased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

stress-induced phosphoprotein 1

multiple interactions
decreases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of STIP1 mRNA
Zinc deficiency results in decreased expression of STIP1 mRNA

PMID:12888634 PMID:18593933

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654

G

serine/threonine kinase 26

decreases expression

ISO

Zinc deficiency results in decreased expression of STK26 mRNA

NCBI chr X:135,195,176...135,259,994
Ensembl chr X:135,195,204...135,259,993

G

serine threonine kinase 39

decreases expression

ISO

Zinc deficiency results in decreased expression of STK39 mRNA

NCBI chr 3:73,321,522...73,588,397
Ensembl chr 3:73,321,522...73,586,740

G

serine/threonine kinase 40

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of STK40 mRNA

NCBI chr 5:143,660,438...143,702,336
Ensembl chr 5:143,665,090...143,702,335

G

steroid sulfatase

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of STS mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of STS mRNA]

NCBI chr X:46,102,524...46,110,868
Ensembl chr X:46,102,548...46,111,104

G

STT3 oligosaccharyltransferase complex catalytic subunit A

increases expression

ISO

Zinc deficiency results in increased expression of STT3A mRNA

NCBI chr 8:44,632,473...44,671,960
Ensembl chr 8:44,632,473...44,672,226

G

syntaxin 16

decreases expression

ISO

Zinc deficiency results in decreased expression of STX16 mRNA

NCBI chr 3:183,271,417...183,300,746
Ensembl chr 3:183,272,031...183,300,745

G

syntaxin 2

decreases expression

EXP

Zinc deficiency results in decreased expression of STX2 mRNA

NCBI chr12:33,315,447...33,350,788
Ensembl chr12:33,315,750...33,350,788

G

syntaxin 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of STX3 mRNA

NCBI chr 1:217,940,697...218,114,865
Ensembl chr 1:217,909,169...218,110,466

G

syntaxin 4

decreases expression

EXP

Zinc deficiency results in decreased expression of STX4 mRNA

NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774

G

syntaxin 6

increases expression

EXP

Zinc deficiency results in increased expression of STX6 mRNA

NCBI chr13:69,882,647...69,928,895
Ensembl chr13:69,882,620...69,931,036

G

succinate receptor 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SUCNR1 mRNA

NCBI chr 2:146,368,858...146,380,360
Ensembl chr 2:146,368,858...146,380,360

G

SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of SUGT1 mRNA

NCBI chr15:61,400,478...61,441,303
Ensembl chr15:61,400,004...61,468,852

G

sulfatase 1

increases expression

EXP

Zinc results in increased expression of SULF1 mRNA

NCBI chr 5:11,145,950...11,308,622
Ensembl chr 5:11,145,950...11,308,643

G

sulfotransferase family 1A member 1

increases expression

EXP

Zinc results in increased expression of SULT1A1 mRNA

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1E member 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of SULT1E1 mRNA

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2

decreases expression

EXP

Zinc deficiency results in decreased expression of SULT2A2 mRNA

NCBI chr 1:85,037,518...85,104,532
Ensembl chr 1:84,962,100...85,104,511

G

synapsin II

decreases expression

EXP

Zinc deficiency results in decreased expression of SYN2 mRNA

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650

G

spectrin repeat containing nuclear envelope protein 1

increases expression

ISO

Zinc deficiency results in increased expression of SYNE1 mRNA

NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721

G

TGF-beta activated kinase 1 (MAP3K7) binding protein 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TAB3 mRNA

NCBI chr X:53,923,473...53,995,777
Ensembl chr X:53,923,492...53,995,610

G

transforming, acidic coiled-coil containing protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TACC2 mRNA

NCBI chr 1:194,546,428...194,758,152
Ensembl chr 1:194,569,650...194,758,152

G

TATA-box binding protein associated factor 15

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TAF15 mRNA

NCBI chr10:68,770,408...68,802,458
Ensembl chr10:68,770,430...68,802,458

G

TATA-box binding protein associated factor 4

affects expression

ISO

Zinc affects the expression of TAF4 mRNA

NCBI chr 3:187,395,632...187,461,042
Ensembl chr 3:187,395,632...187,461,123

G

TATA-box binding protein associated factor 7

decreases expression
multiple interactions

ISO

Zinc deficiency results in decreased expression of TAF7 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of TAF7 mRNA

PMID:18593933 PMID:22171008

NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,705,920...29,712,712

G

TATA-box binding protein associated factor 9

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TAF9 mRNA

NCBI chr 2:33,528,388...33,532,395
Ensembl chr 2:33,531,368...33,536,078

G

transporter 1, ATP binding cassette subfamily B member

increases expression

ISO

Zinc deficiency results in increased expression of TAP1 mRNA

NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810

G

TATA-box binding protein like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TBPL1 mRNA

NCBI chr 1:24,597,028...24,622,445
Ensembl chr 1:24,597,074...24,622,439

G

T-box brain transcription factor 1

multiple interactions

EXP

Zinc inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of TBR1 protein]

NCBI chr 3:66,758,805...66,769,626
Ensembl chr 3:66,759,803...66,769,626

G

T-box transcription factor 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TBX3 mRNA

NCBI chr12:42,540,378...42,555,490
Ensembl chr12:42,540,378...42,554,171

G

transcription elongation factor A like 9

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TCEAL9 mRNA

NCBI chr X:104,037,274...104,039,345
Ensembl chr X:104,032,421...104,041,562

G

transcription factor 3

decreases expression

ISO

Zinc deficiency results in decreased expression of TCF3 mRNA

NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,928,685...9,953,044

G

transcription factor 4

increases expression

ISO

Zinc deficiency results in increased expression of TCF4 mRNA

NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401

G

t-complex 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TCP1 mRNA

NCBI chr 1:50,376,848...50,384,527
Ensembl chr 1:50,376,848...50,384,527

G

terminal nucleotidyltransferase 5A

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TENT5A mRNA
Zinc deficiency results in increased expression of TENT5A mRNA

PMID:18593933 PMID:22171008

NCBI chr 8:95,102,349...95,109,100
Ensembl chr 8:95,105,412...95,109,100

G

testin LIM domain protein

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TES mRNA

NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:46,331,257...46,369,780

G

transferrin

affects binding

ISO

TF protein binds to Zinc; Zinc binds to TF protein

PMID:17034863 PMID:23896426

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

transcription factor AP-2 gamma

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TFAP2C mRNA

NCBI chr 3:181,733,524...181,742,412
Ensembl chr 3:181,733,419...181,741,404

G

trefoil factor 2

increases expression

ISO

Zinc deficiency results in increased expression of TFF2 mRNA

NCBI chr20:9,217,110...9,220,979
Ensembl chr20:9,217,121...9,220,979

G

tissue factor pathway inhibitor 2

increases expression

ISO

Zinc results in increased expression of TFPI2 mRNA

NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426

G

transferrin receptor

multiple interactions
increases expression

ISO

[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein; Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]; etiron promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]
Zinc deficiency results in increased expression of TFRC mRNA; Zinc deficiency results in increased expression of TFRC protein

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

TDP-glucose 4,6-dehydratase

decreases expression

ISO

Zinc deficiency results in decreased expression of TGDS mRNA

NCBI chr15:101,581,765...101,602,779
Ensembl chr15:101,582,227...101,602,718

G

transforming growth factor, beta 1

multiple interactions

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TGFB1 mRNA
[Zinc binds to calcium silicate] which results in increased expression of TGFB1 mRNA
[Zinc binds to Curcumin] which affects the expression of TGFB1 mRNA; Zinc inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]

PMID:16979875 PMID:19589337 PMID:23483914 PMID:31009641

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TGFB2 mRNA
Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]

PMID:16979875 PMID:26354774

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

TGFB-induced factor homeobox 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in decreased expression of TGIF1 mRNA

NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:118,194,444...118,204,442

G

transglutaminase 2

decreases expression
multiple interactions

EXP

Zinc deficiency results in decreased expression of TGM2 mRNA
Zinc inhibits the reaction [Zinc deficiency results in decreased expression of TGM2 mRNA]

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

tyrosine hydroxylase

increases expression
decreases expression
multiple interactions

EXP

Zinc results in increased expression of TH protein
Zinc results in decreased expression of TH protein
Paraquat promotes the reaction [Zinc results in decreased expression of TH protein]; Zinc promotes the reaction [Paraquat results in decreased expression of TH protein]

PMID:11165868 PMID:32060784

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

THAP domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of THAP1 mRNA

NCBI chr16:72,608,096...72,612,690
Ensembl chr16:72,607,305...72,612,690

G

thrombomodulin

decreases expression

EXP

Zinc results in decreased expression of THBD mRNA

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582

G

thymocyte selection associated

decreases expression

ISO

Zinc deficiency results in decreased expression of THEMIS mRNA

NCBI chr 1:18,251,136...18,483,851
Ensembl chr 1:18,272,056...18,483,502

G

thrombopoietin

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of THPO mRNA

Ensembl chr11:93,686,834...93,693,320

G

thyroid hormone receptor beta

decreases expression

EXP

Zinc deficiency results in decreased expression of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

thyroid hormone responsive

increases expression
decreases expression

EXP
ISO

Zinc deficiency results in increased expression of THRSP mRNA
Zinc deficiency results in decreased expression of THRSP mRNA

PMID:12672911 PMID:15671213 PMID:20857495

NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827

G

Thy-1 cell surface antigen

increases expression

ISO

Zinc deficiency results in increased expression of THY1 mRNA

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

TIA1 cytotoxic granule-associated RNA binding protein

affects binding

ISO

Zinc binds to TIA1 protein

NCBI chr 4:120,410,180...120,440,676
Ensembl chr 4:120,410,251...120,440,665

G

TIR domain containing adaptor molecule 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TICAM2 mRNA

NCBI chr18:41,481,057...41,498,065
Ensembl chr18:41,478,539...41,512,243

G

translocase of inner mitochondrial membrane 17A

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TIMM17A mRNA

NCBI chr13:49,282,918...49,296,363
Ensembl chr13:49,282,918...49,307,904

G

TIMP metallopeptidase inhibitor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

TIMP metallopeptidase inhibitor 3

increases expression

EXP

Zinc results in increased expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

TCDD-inducible poly(ADP-ribose) polymerase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406

G

thymidine kinase 1

increases expression

ISO

Zinc deficiency results in increased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228

G

talin 1

increases expression

ISO

Zinc deficiency results in increased expression of TLN1 mRNA

NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:62,583,731...62,613,687

G

toll-like receptor 4

increases expression

EXP

Zinc deficiency results in increased expression of TLR4 mRNA

PMID:19111725 PMID:22689922

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

toll-like receptor 6

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TLR6 mRNA

NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,698,751...43,740,462

G

transmembrane protein 106A

increases expression

ISO

Zinc deficiency results in increased expression of TMEM106A mRNA

NCBI chr10:87,007,144...87,016,161
Ensembl chr10:87,007,165...87,016,157

G

transmembrane protein 106B

decreases expression

ISO

Zinc deficiency results in decreased expression of TMEM106B mRNA

NCBI chr 4:42,294,074...42,313,426
Ensembl chr 4:42,294,101...42,313,407

G

transmembrane protein 117

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TMEM117 mRNA

NCBI chr 7:127,636,862...128,098,944
Ensembl chr 7:127,636,825...128,098,941

G

transmembrane protein 170A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TMEM170A mRNA

NCBI chr19:56,743,221...56,756,085

G

transmembrane protein 204

decreases expression

ISO

Zinc deficiency results in decreased expression of TMEM204 mRNA

NCBI chr10:14,581,025...14,608,878
Ensembl chr10:14,581,026...14,606,427

G

transmembrane protein 214

increases expression

ISO

Zinc deficiency results in increased expression of TMEM214 mRNA

NCBI chr 6:31,222,635...31,231,659
Ensembl chr 6:31,222,635...31,230,381

G

transmembrane protein 230

decreases expression

ISO

Zinc deficiency results in decreased expression of TMEM230 mRNA

NCBI chr 3:139,925,878...139,950,517

G

transmembrane protein 35B

decreases expression

ISO

Zinc deficiency results in decreased expression of TMEM35B mRNA

NCBI chr 5:144,730,763...144,734,393
Ensembl chr 5:144,728,845...144,746,265

G

transmembrane protein 50B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TMEM50B mRNA

NCBI chr11:44,290,805...44,323,650
Ensembl chr11:44,290,807...44,323,607

G

TMEM9 domain family, member B

decreases expression

ISO

Zinc deficiency results in decreased expression of TMEM9B mRNA

NCBI chr 1:173,199,225...173,218,674
Ensembl chr 1:173,200,869...173,218,053

G

trimethyllysine hydroxylase, epsilon

decreases expression

ISO

Zinc deficiency results in decreased expression of TMLHE mRNA

NCBI chr20:96,561...144,414
Ensembl chr20:107,516...144,543

G

tropomodulin 2

decreases expression

ISO

Zinc deficiency results in decreased expression of TMOD2 mRNA

NCBI chr 8:85,197,222...85,250,627
Ensembl chr 8:85,196,226...85,246,371

G

transmembrane serine protease 11D

increases expression
multiple interactions

EXP

Zinc deficiency results in increased expression of TMPRSS11D mRNA
Zinc inhibits the reaction [Zinc deficiency results in increased expression of TMPRSS11D mRNA]

PMID:16140947 PMID:19111725

NCBI chr14:22,062,129...22,124,189
Ensembl chr14:22,062,131...22,124,505

G

tenascin C

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNC mRNA

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

affects abundance
increases abundance
increases secretion
increases expression
decreases expression
decreases uptake
multiple interactions
affects expression

ISO
EXP

TNF gene SNP affects the abundance of Zinc
TNF protein results in increased abundance of Zinc
Zinc results in increased secretion of TNF protein
Zinc results in increased expression of TNF mRNA; Zinc results in increased expression of TNF protein
Zinc results in decreased expression of TNF mRNA; Zinc results in decreased expression of TNF protein
Zinc deficiency results in increased expression of TNF; Zinc deficiency results in increased expression of TNF mRNA; Zinc results in increased expression of TNF protein
TNF protein results in decreased uptake of Zinc
[Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]; Paraquat promotes the reaction [Zinc results in increased expression of TNF protein]; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]; Zinc inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Zinc promotes the reaction [Paraquat results in increased expression of TNF protein]
[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc; MT1 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; MT2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; NOS2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL10 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL7 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL5 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP1A mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA]; Zinc deficiency promotes the reaction [Dietary Fats results in increased expression of TNF protein]; Zinc inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Zinc promotes the reaction [FCER1A protein results in increased expression of TNF mRNA]; Zinc promotes the reaction [FCER1A protein results in increased expression of TNF protein]
[TNF protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc; [TNF protein results in increased expression of SLC39A8 protein] which results in increased import of Zinc; [Zinc co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; Cycloheximide inhibits the reaction [Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]]; Dactinomycin inhibits the reaction [Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]]; Lipopolysaccharides promotes the reaction [Zinc results in increased secretion of TNF protein]; Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of TNF protein]; Zinc inhibits the reaction [TNF protein affects the localization of RELA protein]; Zinc inhibits the reaction [TNF protein results in increased activity of RELA protein]; Zinc inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of ICAM1 protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of IL6ST protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of MMP9 protein]; Zinc inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; Zinc promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Zinc affects the expression of TNF mRNA; Zinc affects the expression of TNF protein

PMID:2107032 PMID:7532385 PMID:8980878 PMID:10938463 PMID:12812920 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions
increases expression

ISO

Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased activity of TNFAIP3 protein]; Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]; Zinc deficiency inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TNFAIP3 protein]; Zinc deficiency inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]; Zinc promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [TRAF1 protein binds to TNFAIP3 protein]]
Zinc results in increased expression of TNFAIP3 mRNA; Zinc results in increased expression of TNFAIP3 protein

PMID:15451058 PMID:20427734 PMID:21035309

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 10b

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF10A mRNA

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF receptor superfamily member 11A

decreases expression

EXP

Zinc deficiency results in decreased expression of TNFRSF11A mRNA; Zinc deficiency results in decreased expression of TNFRSF11A protein

NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257

G

TNF receptor superfamily member 12A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF receptor superfamily member 13B

increases expression

ISO

Zinc deficiency results in increased expression of TNFRSF13B mRNA

NCBI chr10:46,301,336...46,322,460
Ensembl chr10:46,301,316...46,324,408

G

TNF receptor superfamily member 17

increases expression

ISO

Zinc deficiency results in increased expression of TNFRSF17 mRNA

NCBI chr10:4,808,023...4,813,857

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

ISO

Zinc results in increased expression of TNFRSF1A protein
Zinc deficiency results in increased expression of TNFRSF1A protein
[Zinc deficiency co-treated with Ethanol] results in increased expression of TNFRSF1A protein

PMID:18842795 PMID:24155903

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 8

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFRSF8 mRNA

NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620

G

TNF receptor superfamily member 9

affects expression
multiple interactions

ISO

Zinc affects the expression of TNFRSF9 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of TNFRSF9 mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNFRSF9 mRNA

PMID:16979875 PMID:18593933

NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831

G

TNF superfamily member 14

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of TNFSF14 mRNA

NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,155,270...2,160,191

G

TNF superfamily member 4

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFSF4 mRNA

NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133

G

TNF superfamily member 9

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TNFSF9 mRNA

NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339

G

troponin I2, fast skeletal type

decreases expression

EXP

Zinc deficiency results in decreased expression of TNNI2 mRNA

NCBI chr 1:206,882,358...207,027,034
Ensembl chr 1:207,024,416...207,027,038

G

TNNI3 interacting kinase

increases expression

ISO

Zinc deficiency results in increased expression of TNNI3K mRNA

NCBI chr 2:246,397,051...246,665,000
Ensembl chr 2:246,396,891...246,664,954

G

troponin T2, cardiac type

multiple interactions

ISO

Zinc inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

G

troponin T3, fast skeletal type

decreases expression

EXP

Zinc deficiency results in decreased expression of TNNT3 mRNA

NCBI chr 1:207,082,014...207,099,014
Ensembl chr 1:207,081,812...207,099,423

G

trinucleotide repeat containing 18

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TNRC18 mRNA

NCBI chr12:16,868,930...16,965,224
Ensembl chr12:16,868,978...16,965,217

G

transducer of ERBB2, 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TOB2 mRNA

NCBI chr 7:115,242,843...115,251,563
Ensembl chr 7:115,239,895...115,258,155

G

TOG array regulator of axonemal microtubules 2

decreases expression

ISO

Zinc deficiency results in decreased expression of TOGARAM2 mRNA

NCBI chr 6:29,491,183...29,549,004
Ensembl chr 6:29,491,040...29,548,977

G

target of myb1 membrane trafficking protein

increases expression

EXP

Zinc deficiency results in increased expression of TOM1 mRNA

NCBI chr19:13,411,227...13,446,129
Ensembl chr19:13,411,157...13,446,110

G

DNA topoisomerase I

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TOP1 mRNA

NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327

G

DNA topoisomerase II alpha

increases expression

ISO

Zinc deficiency results in increased expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

torsin family 1, member B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TOR1B mRNA

NCBI chr 3:34,640,929...34,647,023
Ensembl chr 3:34,640,931...34,647,027

G

tumor protein p53

affects expression
affects localization
decreases response to substance
multiple interactions
increases expression
increases response to substance
affects binding
affects folding

ISO
EXP

Zinc affects the expression of TP53 protein
Zinc affects the localization of TP53 protein
TRP53 protein results in decreased susceptibility to Zinc deficiency
[SLC30A10 protein affects the abundance of Zinc] which affects the expression of TP53 protein; [SLC30A3 protein affects the abundance of Zinc] which affects the expression of TP53 protein
Zinc deficiency results in increased expression of TP53 mRNA; Zinc results in increased expression of TP53 protein
TP53 protein results in increased susceptibility to Zinc
sodium arsenite inhibits the reaction [Zinc binds to TP53 protein]; TP53 protein inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; TP53 protein inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; TP53 protein promotes the reaction [Zinc results in increased abundance of Reactive Oxygen Species]
[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in decreased expression of FEN1 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in decreased expression of WNT10B mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DAD1 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DDX6 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DRD2 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of HMGA1 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT1 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of KRT14 protein; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of PJA1 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of PNMT mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of RNASEL mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of SDF4 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of SPINK1 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFRSF8 mRNA; [Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFSF4 mRNA; Acetylcysteine inhibits the reaction [Zinc results in increased expression of TRP53 protein]; TRP53 gene mutant form promotes the reaction [Zinc deficiency results in increased expression of KRT14 protein]; TRP53 protein results in decreased susceptibility to [Zinc deficiency co-treated with nitrosobenzylmethylamine]; Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]
Zinc results in increased expression of TRP53 mRNA; Zinc results in increased expression of TRP53 protein
Zinc affects the folding of TP53 protein

PMID:11864783 PMID:12107073 PMID:12517797 PMID:12888634 PMID:15880691 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible nuclear protein 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TP53INP2 mRNA

NCBI chr 3:164,341,618...164,350,270
Ensembl chr 3:164,343,205...164,350,225

G

tumor protein p73

multiple interactions
decreases expression

ISO

Zinc binds to and affects the folding of and affects the activity of TP73 protein
Zinc deficiency results in decreased expression of TP73 mRNA

PMID:17170001 PMID:18356318

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

triosephosphate isomerase 1

affects binding

ISO

TPI1 protein binds to Zinc

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

tropomyosin 1

decreases expression

EXP

Zinc deficiency results in decreased expression of TPM1 mRNA; Zinc deficiency results in decreased expression of TPM1 protein

PMID:19111725 PMID:22689922

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468

G

tropomyosin 4

decreases expression

EXP

Zinc results in decreased expression of TPM4 mRNA

NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494

G

tyrosylprotein sulfotransferase 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TPST2 mRNA

NCBI chr12:49,982,281...50,024,489
Ensembl chr12:49,982,281...50,023,058

G

TPX2, microtubule nucleation factor

increases expression

ISO

Zinc deficiency results in increased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:161,778,742...161,820,724

G

transformer 2 alpha

decreases expression

ISO

Zinc results in decreased expression of TRA2A mRNA

NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:79,551,542...79,570,619

G

transformer 2 beta

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRA2B mRNA

NCBI chr11:92,293,403...92,311,651
Ensembl chr11:92,293,410...92,311,781

G

TNF receptor-associated factor 1

multiple interactions

ISO

Zinc promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [TRAF1 protein binds to TNFAIP3 protein]]

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264

G

Tnf receptor-associated factor 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

Tnf receptor associated factor 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,552,253...63,558,356

G

TNF receptor associated factor 6

increases expression

ISO

Zinc results in increased expression of TRAF6 mRNA

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

translocation associated membrane protein 2

increases expression

ISO

Zinc deficiency results in increased expression of TRAM2 mRNA

NCBI chr 9:30,915,624...30,995,162
Ensembl chr 9:30,915,624...30,995,162

G

triadin

decreases expression

EXP

Zinc deficiency results in decreased expression of TRDN mRNA

NCBI chr 1:25,774,765...26,230,069
Ensembl chr 1:25,774,765...26,229,717

G

thyrotropin-releasing hormone degrading enzyme

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TRHDE mRNA

NCBI chr 7:51,829,473...52,236,843
Ensembl chr 7:51,832,111...52,236,843

G

TP53 regulated inhibitor of apoptosis 1

decreases expression

ISO

Zinc deficiency results in decreased expression of TRIAP1 mRNA

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766

G

tribbles pseudokinase 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

tribbles pseudokinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 11

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRIM11 mRNA

NCBI chr10:44,255,019...44,270,711
Ensembl chr10:44,257,874...44,270,711

G

tripartite motif containing 15

decreases expression

ISO

Zinc deficiency results in decreased expression of TRIM15 mRNA

NCBI chr20:1,703,723...1,715,465
Ensembl chr20:1,706,122...1,715,465

G

tripartite motif-containing 26

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRIM26 mRNA

NCBI chr20:1,711,564...1,736,389
Ensembl chr20:1,715,005...1,736,623

G

tripartite motif-containing 54

decreases expression

EXP

Zinc deficiency results in decreased expression of TRIM54 mRNA

NCBI chr 6:30,959,306...30,978,475
Ensembl chr 6:30,959,306...30,978,475

G

tripartite motif family-like 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TRIML2 mRNA

NCBI chr16:55,677,142...55,693,379
Ensembl chr16:55,677,142...55,693,379

G

thyroid hormone receptor interactor 13

increases expression

ISO

Zinc deficiency results in increased expression of TRIP13 mRNA

NCBI chr 1:31,185,700...31,230,638
Ensembl chr 1:31,185,594...31,230,634

G

transient receptor potential cation channel, subfamily A, member 1

affects response to substance

ISO

TRPA1 protein affects the susceptibility to Zinc

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325

G

transient receptor potential cation channel, subfamily M, member 3

increases expression

ISO

Zinc deficiency results in increased expression of TRPM3 mRNA

NCBI chr 1:229,099,741...229,984,172
Ensembl chr 1:229,099,542...229,984,172

G

transient receptor potential cation channel, subfamily M, member 7

decreases abundance
increases transport

ISO

TRPM7 gene mutant form results in decreased abundance of Zinc
TRPM7 protein results in increased transport of Zinc

NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:134,499,617...134,588,113

G

transient receptor potential cation channel, subfamily V, member 5

increases import

ISO

TRPV5 protein results in increased import of Zinc

NCBI chr 4:71,503,085...71,531,134
Ensembl chr 4:71,503,093...71,529,384

G

transient receptor potential cation channel, subfamily V, member 6

increases uptake

ISO

TRPV6 protein results in increased uptake of Zinc

NCBI chr 4:71,474,006...71,489,667
Ensembl chr 4:71,474,007...71,489,671

G

TSC complex subunit 2

increases expression

ISO

Zinc results in increased expression of TSC2 mRNA

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600

G

TSC22 domain family, member 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TSC22D2 mRNA

NCBI chr 2:144,796,760...144,847,930
Ensembl chr 2:144,796,841...144,843,559

G

TSC22 domain family, member 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TSC22D3 mRNA
[zinc chloride results in increased abundance of Zinc] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

PMID:18593933 PMID:29957541

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

teashirt zinc finger homeobox 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TSHZ1 mRNA

NCBI chr18:79,651,256...79,727,662
Ensembl chr18:79,651,256...79,727,662

G

tetraspanin 13

decreases expression

ISO

Zinc deficiency results in decreased expression of TSPAN13 mRNA

NCBI chr 6:58,466,051...58,492,804
Ensembl chr 6:58,465,684...58,492,819

G

TSPY-like 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TSPYL2 mRNA

NCBI chr X:24,918,851...24,924,462
Ensembl chr X:24,918,851...24,924,462

G

tetratricopeptide repeat domain 22

increases expression

ISO

Zinc deficiency results in increased expression of TTC22 mRNA

NCBI chr 5:126,630,808...126,651,954
Ensembl chr 5:126,634,864...126,651,949

G

tetratricopeptide repeat domain 9C

increases expression

ISO

Zinc results in increased expression of TTC9C protein

NCBI chr 1:215,130,887...215,142,384
Ensembl chr 1:215,130,888...215,141,585

G

transthyretin

multiple interactions
affects binding
increases expression

ISO
EXP

Zinc affects the reaction [TTR protein mutant form binds to TTR protein mutant form]
[zinc chloride results in increased abundance of Zinc] which results in increased expression of TTR mRNA
TTR protein binds to Zinc
Zinc deficiency results in increased expression of TTR mRNA

PMID:7854157 PMID:17630783 PMID:23896426 PMID:31588059

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

tubulin, alpha-like 3

increases expression

ISO

Zinc deficiency results in increased expression of TUBAL3 mRNA

NCBI chr17:71,233,194...71,245,297
Ensembl chr17:71,232,851...71,245,337

G

tubulin, beta 3 class III

increases expression
multiple interactions

EXP
ISO

Zinc deficiency results in increased expression of TUBB3 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of TUBB3 mRNA

PMID:18593933 PMID:19111725

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

Tu translation elongation factor, mitochondrial

affects binding

ISO

TUFM protein binds to Zinc

NCBI chr 1:190,504,373...190,507,980
Ensembl chr 1:190,504,373...190,508,952

G

tuftelin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TUFT1 mRNA

NCBI chr 2:184,949,437...184,995,321
Ensembl chr 2:184,949,437...184,995,383

G

TUB like protein 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TULP3 mRNA

NCBI chr 4:163,276,583...163,318,297
Ensembl chr 4:163,276,583...163,318,390

G

terminal uridylyl transferase 1, U6 snRNA-specific

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TUT1 mRNA

NCBI chr 1:215,277,802...215,288,869

G

terminal uridylyl transferase 7

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TUT7 mRNA

NCBI chr17:4,854,553...4,908,758
Ensembl chr17:4,855,936...4,909,070

G

thioredoxin 1

multiple interactions
increases expression

ISO

[Zinc deficiency co-treated with Ethanol] results in increased expression of TXN protein
Zinc deficiency results in increased expression of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin domain containing 11

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of TXNDC11 mRNA
Zinc deficiency results in increased expression of TXNDC11 mRNA

PMID:18593933 PMID:22171008

NCBI chr10:5,022,464...5,079,958
Ensembl chr10:5,022,435...5,079,950

G

thioredoxin domain containing 5

increases expression

ISO

Zinc deficiency results in increased expression of TXNDC5 mRNA

NCBI chr17:26,495,467...26,523,608
Ensembl chr17:26,490,047...26,523,597

G

thioredoxin reductase 1

multiple interactions

ISO

Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 3

multiple interactions

ISO

Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]

NCBI chr 4:123,629,768...123,669,713
Ensembl chr 4:123,648,750...123,668,552

G

thymidylate synthetase

increases expression

ISO

Zinc deficiency results in increased expression of TYMS mRNA

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

tyrosinase

multiple interactions

ISO

[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

tyrosinase-related protein 1

multiple interactions

ISO

[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA]

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

U2 small nuclear RNA auxiliary factor 2

increases expression

EXP

Zinc deficiency results in increased expression of U2AF2 mRNA

NCBI chr 1:77,789,752...77,807,307
Ensembl chr 1:77,789,752...77,807,413

G

ubiquitin-like modifier activating enzyme 1

increases expression

ISO

Zinc deficiency results in increased expression of UBA1 mRNA

NCBI chr X:4,062,216...4,084,192
Ensembl chr X:4,062,182...4,084,246

G

ubiquitin-like modifier activating enzyme 7

increases expression

ISO

Zinc deficiency results in increased expression of UBA7 mRNA

NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:117,543,957...117,556,142

G

ubiquitin-associated protein 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBAP1 mRNA

NCBI chr 5:61,316,650...61,357,077
Ensembl chr 5:61,316,643...61,357,076

G

ubiquitin C

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBC mRNA

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275

G

ubiquitin-conjugating enzyme E2B

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBE2B mRNA

NCBI chr10:36,749,365...36,764,335
Ensembl chr10:36,749,369...36,765,587

G

ubiquitin-conjugating enzyme E2C

increases expression

ISO

Zinc deficiency results in increased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

ubiquitin-conjugating enzyme E2D 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBE2D3 mRNA

NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:226,540,531...226,573,144

G

ubiquitin-conjugating enzyme E2H

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBE2H mRNA

NCBI chr 4:59,802,102...59,897,583
Ensembl chr 4:59,802,102...59,897,583

G

ubiquitin-conjugating enzyme E2, J1

increases expression

ISO

Zinc deficiency results in increased expression of UBE2J1 mRNA

NCBI chr 5:52,218,807...52,237,805
Ensembl chr 5:52,218,807...52,237,805

G

ubiquitin-conjugating enzyme E2M

increases expression

ISO

Zinc deficiency results in increased expression of UBE2M mRNA

NCBI chr 1:82,734,761...82,738,298
Ensembl chr 1:82,732,231...82,738,613

G

ubiquilin 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBQLN1 mRNA

NCBI chr17:6,438,456...6,482,498
Ensembl chr17:6,444,124...6,482,499

G

ubiquitin protein ligase E3 component n-recognin 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UBR2 mRNA

NCBI chr 9:21,480,058...21,559,936
Ensembl chr 9:21,480,037...21,559,936

G

uncoupling protein 3

increases expression
multiple interactions

EXP
ISO

Zinc results in increased expression of UCP3 mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of UCP3 mRNA

PMID:17074742 PMID:18593933

NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210

G

UDP-glucose ceramide glucosyltransferase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UGCG mRNA

NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

EXP

[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of UGT1A1 mRNA]; [Taurine binds to Zinc] which results in decreased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ISO

Zinc deficiency results in increased expression of UGT1A3 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glycosyltransferase 2 family, polypeptide B

increases expression

EXP

Zinc deficiency results in increased expression of UGT2B mRNA

NCBI chr14:20,985,449...21,006,267
Ensembl chr14:20,985,108...21,020,850

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions

EXP

[Taurine binds to Zinc] inhibits the reaction [Doxorubicin results in decreased expression of UGT2B1 mRNA]; [Taurine binds to Zinc] which results in increased expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

ubiquitin-like with PHD and ring finger domains 1

increases expression

ISO

Zinc deficiency results in increased expression of UHRF1 mRNA

NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792

G

unc-51 like autophagy activating kinase 1

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ULK1 mRNA

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

G

unc-119 lipid binding chaperone

affects expression
increases expression

ISO

Zinc affects the expression of UNC119 mRNA
Zinc results in increased expression of UNC119 mRNA

PMID:15226459 PMID:16979875

NCBI chr10:63,735,927...63,741,404
Ensembl chr10:63,735,777...63,741,404

G

UPF1, RNA helicase and ATPase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UPF1 mRNA

NCBI chr16:19,110,531...19,131,327
Ensembl chr16:19,110,538...19,131,327

G

UPF2, regulator of nonsense mediated mRNA decay

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UPF2 mRNA

NCBI chr17:77,133,975...77,245,266
Ensembl chr17:77,134,716...77,245,704

G

uroplakin 1B

decreases expression

EXP

Zinc deficiency results in decreased expression of UPK1B mRNA

NCBI chr11:75,459,244...75,496,579
Ensembl chr11:75,459,200...75,496,579

G

ubiquinol-cytochrome c reductase complex assembly factor 4

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of UQCC4 mRNA

NCBI chr10:14,706,720...14,708,022
Ensembl chr10:14,706,709...14,708,555

G

unconventional SNARE in the ER 1

increases expression

ISO

Zinc results in increased expression of USE1 mRNA

NCBI chr16:18,069,118...18,075,816
Ensembl chr16:18,070,793...18,075,814

G

USH1 protein network component harmonin

decreases expression

ISO

Zinc results in decreased expression of USH1C mRNA

NCBI chr 1:105,831,719...105,880,082
Ensembl chr 1:105,831,723...105,880,082

G

ubiquitin specific peptidase 18

increases expression

ISO

Zinc deficiency results in increased expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:156,143,815...156,171,292

G

ubiquitin specific peptidase 2

multiple interactions

ISO

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794

G

ubiquitin specific peptidase 36

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of USP36 mRNA

NCBI chr10:103,995,970...104,027,492
Ensembl chr10:103,995,970...104,023,450

G

ubiquitin specific peptidase like 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of USPL1 mRNA

NCBI chr12:10,859,764...10,886,761
Ensembl chr12:10,859,764...10,886,744

G

vesicle-associated membrane protein 4

decreases expression

ISO

Zinc deficiency results in decreased expression of VAMP4 mRNA

NCBI chr13:77,453,135...77,475,909
Ensembl chr13:77,453,121...77,476,024

G

vasohibin 2

decreases expression

ISO

Zinc deficiency results in decreased expression of VASH2 mRNA

NCBI chr13:105,060,857...105,092,325
Ensembl chr13:105,060,857...105,092,275

G

vascular cell adhesion molecule 1

increases expression
multiple interactions
decreases expression

EXP
ISO

Zinc deficiency results in increased expression of VCAM1
Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VCAM1 protein]; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of VCAM1 protein]
[LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 mRNA; [LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 protein; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA]; Zinc deficiency promotes the reaction [Dietary Fats results in increased expression of VCAM1 protein]; Zinc inhibits the reaction [Dietary Fats results in increased expression of VCAM1 protein]
Zinc results in decreased expression of VCAM1 protein

PMID:16140885 PMID:20128680 PMID:20427734 PMID:21035309 PMID:23503329 More...

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vitamin D receptor

increases activity

ISO

Zinc deficiency results in increased activity of VDR protein

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

vascular endothelial growth factor A

multiple interactions
affects expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of VEGFA mRNA; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VEGFA mRNA; Zinc inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]
Zinc affects the expression of VEGFA mRNA

PMID:16606632 PMID:16979875 PMID:18593933

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vascular endothelial growth factor C

decreases expression

EXP

Zinc results in decreased expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887

G

vascular endothelial growth factor D

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of VEGFD mRNA

NCBI chr X:33,704,582...33,740,305
Ensembl chr X:33,706,055...33,740,167

G

vasoactive intestinal peptide receptor 2

multiple interactions
affects expression

ISO
EXP

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VIPR2 mRNA
Zinc affects the expression of VIPR2 mRNA

PMID:16413754 PMID:16979875

NCBI chr 6:143,139,672...143,213,609
Ensembl chr 6:143,144,523...143,213,609

G

vanin 1

affects expression
multiple interactions

ISO

Zinc affects the expression of VNN1 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of VNN1 mRNA

PMID:16979875 PMID:33549593

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

VPS37B subunit of ESCRT-I

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of VPS37B mRNA

NCBI chr12:38,220,973...38,249,935
Ensembl chr12:38,220,959...38,249,935

G

VPS8 subunit of CORVET complex

increases expression

ISO

Zinc deficiency results in increased expression of VPS8 mRNA

NCBI chr11:92,906,702...93,140,844
Ensembl chr11:92,906,700...93,138,570

G

VRK serine/threonine kinase 3

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of VRK3 mRNA

NCBI chr 1:104,379,903...104,407,278
Ensembl chr 1:104,379,628...104,407,274

G

vesicle trafficking 1

decreases expression

ISO

Zinc deficiency results in decreased expression of VTA1 mRNA

NCBI chr 1:10,852,966...10,900,764
Ensembl chr 1:10,852,966...10,900,735

G

vitronectin

decreases expression
affects binding

ISO

Zinc deficiency results in decreased expression of VTN mRNA
VTN protein binds to Zinc

PMID:18356318 PMID:23896426

NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,892,766...63,895,860

G

WAPL cohesin release factor

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of WAPL mRNA

NCBI chr16:10,011,741...10,081,472
Ensembl chr16:10,012,110...10,081,472

G

WASP actin nucleation promoting factor

increases expression

ISO

Zinc deficiency results in increased expression of WAS mRNA

NCBI chr X:17,077,057...17,085,802
Ensembl chr X:17,073,314...17,085,802

G

WD repeat domain 20

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of WDR20 mRNA

NCBI chr 6:135,572,502...135,642,688
Ensembl chr 6:135,572,893...135,642,688

G

WD repeat domain 26

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of WDR26 mRNA

NCBI chr13:95,462,017...95,503,826
Ensembl chr13:95,462,020...95,503,738

G

WD repeat domain 46

decreases expression

ISO

Zinc results in decreased expression of WDR46 mRNA

NCBI chr20:4,939,721...4,947,619
Ensembl chr20:4,939,732...4,947,741

G

WD repeat domain 72

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of WDR72 mRNA

NCBI chr 8:83,718,897...83,902,128
Ensembl chr 8:83,718,914...83,900,286

G

WEE1 G2 checkpoint kinase

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

WAS/WASL interacting protein family, member 1

decreases expression

ISO

Zinc deficiency results in decreased expression of WIPF1 mRNA

NCBI chr 3:78,721,486...78,824,199
Ensembl chr 3:78,714,299...78,780,277

G

Wnt family member 10B

multiple interactions

ISO

[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in decreased expression of WNT10B mRNA

NCBI chr 7:131,801,046...131,806,850
Ensembl chr 7:131,801,046...131,806,850

G

WD repeat and SOCS box-containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of WSB1 mRNA

NCBI chr10:64,700,752...64,717,038
Ensembl chr10:64,700,762...64,716,832

G

WW and C2 domain containing 1

decreases expression

ISO

Zinc deficiency results in decreased expression of WWC1 mRNA

NCBI chr10:20,804,173...20,958,437
Ensembl chr10:20,799,237...20,958,437

G

XIAP associated factor 1

affects expression
multiple interactions
increases expression

ISO

Zinc affects the expression of XAF1 protein
MTF1 protein affects the reaction [Zinc results in increased expression of XAF1 mRNA]; MTF1 protein affects the reaction [Zinc results in increased expression of XAF1 protein]

NCBI chr10:57,415,935...57,428,348
Ensembl chr10:57,415,658...57,428,349

G

xanthine dehydrogenase

multiple interactions
increases expression

EXP
ISO

Zinc inhibits the reaction [Indomethacin results in increased activity of XDH protein]
[PCI 5002 co-treated with Zinc] results in increased expression of XDH mRNA
Zinc results in increased expression of XDH mRNA

PMID:12566098 PMID:17074742 PMID:18593933

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-linked inhibitor of apoptosis

multiple interactions
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of XIAP mRNA
Zinc deficiency results in increased expression of XIAP mRNA

PMID:18593933 PMID:19111725

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

XPA, DNA damage recognition and repair factor

multiple interactions
affects binding

ISO

2-nitrophenyl selenocyanic acid inhibits the reaction [Zinc binds to XPA protein]; antimony trichloride inhibits the reaction [XPA protein binds to Zinc]; benzeneseleninic acid inhibits the reaction [Zinc binds to XPA protein]; ebselen inhibits the reaction [Zinc binds to XPA protein]; Selenium Compounds inhibits the reaction [Zinc binds to XPA protein]; selenocystine inhibits the reaction [Zinc binds to XPA protein]; Selenomethionine inhibits the reaction [Zinc binds to XPA protein]; selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein]; sodium arsenite inhibits the reaction [Zinc binds to XPA protein]; Zinc binds to and results in increased activity of XPA protein; Zinc inhibits the reaction [Cadmium Chloride results in decreased activity of XPA protein]; Zinc inhibits the reaction [sodium arsenite results in decreased activity of XPA protein]

PMID:10783332 PMID:15265038 PMID:17512921 PMID:20509621 PMID:28552776 More...

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425

G

X-ray repair cross complementing 4

decreases expression

ISO

Zinc deficiency results in decreased expression of XRCC4 mRNA

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160

G

Yes1 associated transcriptional regulator

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of YAP1 mRNA

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437

G

Y box binding protein 1

increases expression

ISO

Zinc deficiency results in increased expression of YBX1 mRNA

NCBI chr 5:138,167,444...138,188,155
Ensembl chr 5:138,167,444...138,184,188

G

yippee-like 1

increases expression

ISO

Zinc results in increased expression of YPEL1 mRNA

NCBI chr11:97,426,012...97,440,646

G

yippee-like 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of YPEL5 mRNA

NCBI chr 6:28,408,079...28,423,536
Ensembl chr 6:28,408,080...28,412,385

G

yrdC N(6)-threonylcarbamoyltransferase domain containing

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of YRDC mRNA

NCBI chr 5:142,394,833...142,399,798
Ensembl chr 5:142,394,938...142,399,795

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

increases expression

ISO

Zinc deficiency results in increased expression of YWHAE mRNA

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291

G

zinc finger, B-box domain containing

increases expression

ISO

Zinc deficiency results in increased expression of ZBBX mRNA

NCBI chr 2:162,134,252...162,245,538
Ensembl chr 2:162,134,252...162,245,717

G

Z-DNA binding protein 1

increases expression

ISO

Zinc deficiency results in increased expression of ZBP1 mRNA

NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:182,411,665...182,422,839

G

zinc finger and BTB domain containing 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB1 mRNA

NCBI chr 6:100,832,506...100,864,019
Ensembl chr 6:100,838,714...100,852,643

G

zinc finger and BTB domain containing 2

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB2 mRNA

NCBI chr 1:43,232,839...43,252,115
Ensembl chr 1:43,232,839...43,252,614

G

zinc finger and BTB domain containing 20

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB20 mRNA

NCBI chr11:70,558,010...71,297,039
Ensembl chr11:70,580,930...70,736,237

G

zinc finger and BTB domain containing 21

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB21 mRNA

NCBI chr11:50,781,697...50,796,399
Ensembl chr11:50,781,099...50,796,560

G

zinc finger and BTB domain containing 32

increases expression

ISO

Zinc deficiency results in increased expression of ZBTB32 mRNA

NCBI chr 1:94,969,374...94,978,553
Ensembl chr 1:94,969,374...94,971,679

G

zinc finger and BTB domain containing 43

multiple interactions
increases expression

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB43 mRNA
Zinc deficiency results in increased expression of ZBTB43 mRNA

PMID:18593933 PMID:22171008

NCBI chr 3:37,142,210...37,161,524
Ensembl chr 3:37,141,354...37,162,238

G

zinc finger CCCH type containing 12A

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZC3H12A mRNA

NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:142,661,199...142,669,985

G

zinc finger CCHC-type containing 7

decreases expression

ISO

Zinc deficiency results in decreased expression of ZCCHC7 mRNA

NCBI chr 5:63,787,292...63,968,960
Ensembl chr 5:63,788,217...63,968,549

G

zinc finger DHHC-type palmitoyltransferase 14

decreases expression

ISO

Zinc deficiency results in decreased expression of ZDHHC14 mRNA

NCBI chr 1:48,473,860...48,746,201
Ensembl chr 1:48,474,274...48,744,413

G

zinc finger E-box binding homeobox 1

affects expression
multiple interactions

ISO

Zinc affects the expression of ZEB1 mRNA
[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB1 mRNA

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger E-box binding homeobox 2

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB2 mRNA

NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:49,624,028...49,754,323

G

zinc finger AN1-type containing 2A

increases expression
multiple interactions

ISO

Zinc results in increased expression of ZFAND2A mRNA
[PCI 5002 co-treated with Zinc] results in increased expression of ZFAND2A mRNA

PMID:11525245 PMID:18593933

NCBI chr12:20,275,435...20,286,513
Ensembl chr12:20,275,450...20,286,513

G

zinc finger protein 110

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF274 mRNA

NCBI chr 1:82,509,563...82,533,294
Ensembl chr 1:82,517,769...82,533,292

G

zinc finger protein 131

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF131 mRNA

NCBI chr 2:53,457,893...53,486,348
Ensembl chr 2:53,458,515...53,485,285

G

zinc finger protein 174

decreases expression

ISO

Zinc deficiency results in decreased expression of ZNF174 mRNA

NCBI chr10:12,169,012...12,182,775
Ensembl chr10:12,174,540...12,182,689

G

zinc finger protein 24

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF24 mRNA

NCBI chr18:15,573,031...15,583,432
Ensembl chr18:15,574,762...15,582,290

G

zinc finger protein 251

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF251 mRNA

NCBI chr 7:110,449,194...110,479,218
Ensembl chr 7:110,449,194...110,479,218

G

zinc finger protein 263

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF263 mRNA

NCBI chr10:12,270,785...12,280,982
Ensembl chr10:12,234,057...12,277,587

G

zinc finger protein 296

decreases expression

ISO

Zinc results in decreased expression of ZNF296 mRNA

NCBI chr 1:88,356,653...88,359,841
Ensembl chr 1:88,352,530...88,359,840

G

zinc finger protein 341

increases expression

ISO

Zinc deficiency results in increased expression of ZNF341 mRNA

NCBI chr 3:163,582,937...163,616,448
Ensembl chr 3:163,579,298...163,616,446

G

zinc finger protein 36

multiple interactions
increases stability
increases expression

ISO
EXP

[PCI 5002 co-treated with Zinc] results in increased expression of ZFP36 mRNA
Zinc results in increased stability of ZFP36 mRNA
Zinc results in increased expression of ZFP36 mRNA
Zinc deficiency results in increased expression of ZFP36 mRNA

PMID:7860645 PMID:18593933 PMID:19111725

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 382

increases expression

ISO

Zinc results in increased expression of ZFP382 mRNA

NCBI chr 1:94,504,344...94,528,316
Ensembl chr 1:94,505,067...94,528,334

G

zinc finger protein 394

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF394 mRNA

NCBI chr12:14,522,820...14,530,998

G

zinc finger protein 410

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF410 mRNA

NCBI chr 6:109,695,223...109,721,369
Ensembl chr 6:109,695,185...109,722,569

G

zinc finger protein 473

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF473 mRNA

NCBI chr 1:104,358,757...104,379,833
Ensembl chr 1:104,359,709...104,379,775

G

zinc finger protein 574

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF574 mRNA

NCBI chr 1:89,798,412...89,805,490
Ensembl chr 1:89,760,956...89,813,198

G

zinc finger protein 622

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF622 mRNA

NCBI chr 2:78,205,655...78,224,888
Ensembl chr 2:78,066,031...78,225,356

G

zinc finger protein 637

decreases expression

ISO

Zinc deficiency results in decreased expression of ZNF32 mRNA

NCBI chr 4:152,656,937...152,682,499
Ensembl chr 4:152,656,973...152,685,097

G

zinc finger protein 746

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF746 mRNA

NCBI chr 4:78,385,945...78,410,240
Ensembl chr 4:78,385,945...78,409,832

G

zinc finger protein 821

decreases expression

ISO

Zinc deficiency results in decreased expression of ZNF821 mRNA

NCBI chr19:54,589,449...54,608,341
Ensembl chr19:54,590,152...54,608,340

G

zinc finger protein 866

increases expression

EXP

Zinc deficiency results in increased expression of CXCL5 mRNA; Zinc deficiency results in increased expression of CXCL5 protein

NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,702,297...19,709,330

G

zinc finger with KRAB and SCAN domains 5

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZKSCAN5 mRNA

NCBI chr12:14,498,342...14,519,537
Ensembl chr12:14,498,342...14,519,537

G

zinc finger, MIZ-type containing 2

decreases expression

ISO

Zinc deficiency results in decreased expression of ZMIZ2 mRNA

NCBI chr14:85,465,323...85,481,860
Ensembl chr14:85,465,373...85,481,860

G

Zinc finger protein 16 like, pseudogene 1

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF16 mRNA

NCBI chr 7:110,531,504...110,550,857

G

zinc finger protein 235

multiple interactions

ISO

[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZNF235 mRNA

NCBI chr 1:88,826,910...88,836,360
Ensembl chr 1:88,827,737...88,836,359

G

zinc finger protein 408

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZNF408 mRNA

NCBI chr 3:98,071,210...98,077,075
Ensembl chr 3:98,072,568...98,077,196

G

zinc finger and SCAN domain containing 26

decreases expression

ISO

Zinc deficiency results in decreased expression of ZSCAN26 mRNA

NCBI chr17:47,843,822...47,863,799
Ensembl chr17:47,807,150...47,863,790

G

zinc finger, SWIM-type containing 6

multiple interactions

ISO

[PCI 5002 co-treated with Zinc] results in increased expression of ZSWIM6 mRNA

NCBI chr 2:40,944,617...41,112,340
Ensembl chr 2:40,946,435...41,112,519

G

zwilch kinetochore protein

increases expression

ISO

Zinc deficiency results in increased expression of ZWILCH mRNA

NCBI chr 8:73,532,968...73,566,214
Ensembl chr 8:73,533,703...73,571,299

G

zinc finger, X-linked, duplicated B

decreases expression

ISO

Zinc deficiency results in decreased expression of ZXDB mRNA

NCBI chr X:63,710,381...63,716,353
Ensembl chr X:63,710,384...63,775,164

G

zyxin

increases expression

ISO

Zinc deficiency results in increased expression of ZYX mRNA

NCBI chr 4:72,203,991...72,213,181
Ensembl chr 4:72,204,007...72,213,181

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

affects activity
multiple interactions

EXP

mancozeb affects the activity of ACHE protein
[carbendazim co-treated with mancozeb] results in increased activity of ACHE protein

PMID:10641187 PMID:33217513

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

actin, gamma 1

increases expression

ISO

mancozeb results in increased expression of ACTG1 protein

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951

G

actin maturation protease

decreases expression

ISO

mancozeb results in decreased expression of ACTMAP mRNA

NCBI chr 1:91,618,012...91,627,490
Ensembl chr 1:91,617,859...91,627,489

G

AKT serine/threonine kinase 1

multiple interactions

ISO

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

decreases expression

ISO

mancozeb results in decreased expression of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 2 family member

decreases activity
multiple interactions

EXP
ISO

mancozeb results in decreased activity of ALDH2 protein
[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein

PMID:17010440 PMID:34830855

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 5 family, member A1

decreases activity

EXP

mancozeb results in decreased activity of ALDH5A1 protein

NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,558,347...40,586,714

G

angiopoietin-like 1

decreases expression

ISO

mancozeb results in decreased expression of ANGPTL1 mRNA

NCBI chr13:71,463,913...71,531,810
Ensembl chr13:71,511,727...71,531,818

G

annexin A2

decreases expression

ISO

mancozeb results in decreased expression of ANXA2 protein

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

androgen receptor

multiple interactions
decreases expression
decreases activity

ISO

mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased expression of AR mRNA
mancozeb results in decreased activity of AR protein

PMID:23871939 PMID:33396126

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

ISO

mancozeb results in decreased expression of ATP1A2 mRNA

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO

mancozeb results in increased expression of BAX mRNA
mancozeb results in increased expression of BAX protein
[Sulfur co-treated with mancozeb co-treated with metrafenone] results in decreased expression of BAX mRNA; [Sulfur co-treated with mancozeb] results in decreased expression of BAX mRNA; lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]

PMID:27235710 PMID:35564597 PMID:35617905

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

mancozeb results in decreased expression of BCL2 mRNA
mancozeb results in decreased expression of BCL2 protein
[Sulfur co-treated with mancozeb co-treated with metrafenone] results in decreased expression of BCL2 mRNA; [Sulfur co-treated with mancozeb] results in decreased expression of BCL2 mRNA; lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]

PMID:16005924 PMID:27235710 PMID:35564597 PMID:35617905

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

carbonic anhydrase 3

increases expression

ISO

mancozeb results in increased expression of CAR3 protein

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

caspase 3

increases activity
increases expression
multiple interactions
increases cleavage

ISO

mancozeb results in increased activity of CASP3 protein
mancozeb results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]

PMID:22824503 PMID:30037311 PMID:35617905

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity

ISO

mancozeb results in increased activity of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases activity

ISO

mancozeb results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity
increases expression

ISO

mancozeb results in increased activity of CASP9 protein
mancozeb results in increased expression of CASP9 protein

PMID:22824503 PMID:35617905

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity

ISO
EXP

Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]

PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311 PMID:35617905 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

coiled-coil domain containing 106

decreases expression

ISO

mancozeb results in decreased expression of CCDC106 mRNA

NCBI chr 1:77,808,723...77,812,816
Ensembl chr 1:77,808,723...77,852,105

G

cyclin D1

multiple interactions
increases expression

ISO

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein

PMID:19883720 PMID:21375462

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cell division cycle 25C

increases phosphorylation

ISO

mancozeb results in increased phosphorylation of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cilia and flagella associated protein 126

decreases expression

ISO

mancozeb results in decreased expression of CFAP126 mRNA

NCBI chr13:86,059,142...86,075,034
Ensembl chr13:86,059,142...86,075,034

G

claudin 16

decreases expression

ISO

mancozeb results in decreased expression of CLDN16 mRNA

NCBI chr11:87,795,106...87,814,396
Ensembl chr11:87,795,106...87,814,396

G

cardiotrophin 1

decreases expression

ISO

mancozeb results in decreased expression of CTF1 mRNA

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395

G

cytochrome c, somatic

increases expression

ISO

mancozeb results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
decreases expression

EXP
ISO

mancozeb results in decreased activity of CYP1A1 protein
mancozeb results in decreased expression of CYP1A1 protein

PMID:1946188 PMID:31096615

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

ISO

mancozeb results in decreased expression of CYP2B6 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

ISO

mancozeb results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression

ISO

mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage-inducible transcript 4

increases expression

EXP

mancozeb results in increased expression of DDIT4 protein

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DNA methyltransferase 1

decreases expression

ISO

mancozeb results in decreased expression of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

decreases expression

ISO

mancozeb results in decreased expression of DNMT3A protein

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

dual specificity phosphatase 1

decreases expression

ISO

mancozeb results in decreased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

EF-hand calcium binding domain 12

decreases expression

ISO

mancozeb results in decreased expression of EFCAB12 mRNA

NCBI chr 4:150,541,983...150,563,973
Ensembl chr 4:150,541,982...150,563,286

G

ephrin A1

decreases expression

ISO

mancozeb results in decreased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

ephrin A3

decreases expression

ISO

mancozeb results in decreased expression of EFNA3 mRNA

NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:177,026,933...177,044,843

G

ETS transcription factor ELK1

increases phosphorylation

ISO

mancozeb results in increased phosphorylation of ELK1 protein

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

estrogen receptor 1

decreases expression

ISO

mancozeb results in decreased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

decreases expression

ISO

mancozeb results in decreased expression of ESR2 mRNA; mancozeb results in decreased expression of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

coagulation factor III, tissue factor

increases expression

ISO

mancozeb results in increased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

mancozeb results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
decreases expression
increases expression

ISO

lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA]
mancozeb results in decreased expression of GADD45A mRNA

PMID:27235710 PMID:36007320

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

glycine-N-acyltransferase-like 3

decreases expression

ISO

mancozeb results in decreased expression of GLYATL3 mRNA

NCBI chr 9:27,474,057...27,492,281
Ensembl chr 9:27,474,057...27,492,281

G

glutamic-oxaloacetic transaminase 1

affects activity

EXP

mancozeb affects the activity of GOT1 protein

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

affects activity
multiple interactions

EXP

mancozeb affects the activity of GPT protein
[2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide co-treated with mancozeb] results in increased expression of GPT protein; Resveratrol inhibits the reaction [[2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide co-treated with mancozeb] results in increased expression of GPT protein]

PMID:10641187 PMID:37009748

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

decreases expression
multiple interactions

ISO

mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glycogen synthase kinase 3 beta

multiple interactions

ISO

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

H2A.X variant histone

multiple interactions

ISO

[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

histone deacetylase 3

decreases activity

ISO

mancozeb results in decreased activity of HDAC3 protein

NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025

G

histone deacetylase 6

decreases activity

ISO

mancozeb results in decreased activity of HDAC6 protein

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

heterogeneous nuclear ribonucleoprotein M

increases expression

ISO

mancozeb results in increased expression of HNRNPM protein

NCBI chr 7:15,140,877...15,178,871
Ensembl chr 7:15,129,287...15,178,871

G

heat shock protein family A (Hsp70) member 1B

increases expression

ISO

mancozeb results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

interferon induced transmembrane protein 2

decreases expression

ISO

mancozeb results in decreased expression of IFITM2 mRNA

NCBI chr 1:205,481,168...205,482,348

G

interferon gamma

multiple interactions

ISO

mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

multiple interactions

ISO

mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

affects expression

ISO

mancozeb affects the expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

integrin subunit beta 3

decreases expression

ISO

mancozeb results in decreased expression of ITGB3 mRNA; mancozeb results in decreased expression of ITGB3 protein

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

potassium voltage-gated channel subfamily Q member 2

increases activity

EXP

mancozeb results in increased activity of KCNQ2 protein

NCBI chr 3:188,572,345...188,631,391
Ensembl chr 3:188,572,926...188,631,302

G

KiSS-1 metastasis-suppressor

affects expression

EXP

mancozeb affects the expression of KISS1 mRNA

NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906

G

leukotriene B4 receptor 2

increases expression

ISO

mancozeb results in increased expression of LTB4R2 mRNA

NCBI chr15:33,228,634...33,230,453
Ensembl chr15:33,228,634...33,230,453

G

mitogen-activated protein kinase kinase kinase 5

increases expression

ISO

mancozeb results in increased expression of MAP3K5 mRNA

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen-activated protein kinase kinase kinase 6

increases expression

ISO

mancozeb results in increased expression of MAP3K6 mRNA

NCBI chr 5:150,724,029...150,736,113
Ensembl chr 5:150,724,216...150,736,111

G

mitogen activated protein kinase 1

multiple interactions

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MDM2 proto-oncogene

multiple interactions
increases expression

ISO

lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

mitochondrially encoded cytochrome b

decreases expression

ISO

mancozeb results in decreased expression of CYTB mRNA

NCBI chr MT:14,136...15,278
Ensembl chr MT:14,124...15,266

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3

decreases expression

ISO

mancozeb results in decreased expression of ND3 mRNA

NCBI chr MT:9,451...9,798
Ensembl chr MT:9,436...9,783

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L

decreases expression

ISO

mancozeb results in decreased expression of ND4L mRNA

NCBI chr MT:9,870...10,166
Ensembl chr MT:9,855...10,151

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

decreases expression

ISO

mancozeb results in decreased expression of ND6 mRNA

NCBI chr MT:13,543...14,061
Ensembl chr MT:13,531...14,049

G

mucin 1, cell surface associated

decreases expression

ISO

mancozeb results in decreased expression of MUC1 mRNA; mancozeb results in decreased expression of MUC1 protein

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression
increases expression

ISO
EXP

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in decreased expression of MYC mRNA
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]

PMID:16005924 PMID:19883720 PMID:36007320

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

NHL repeat containing E3 ubiquitin protein ligase 1

decreases expression

ISO

mancozeb results in decreased expression of NHLRC1 mRNA

NCBI chr17:17,880,570...17,883,411
Ensembl chr17:17,880,365...17,883,620

G

nitric oxide synthase 2

increases expression
multiple interactions

ISO

mancozeb results in increased expression of NOS2 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NADPH oxidase 4

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

ISO

mancozeb results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

ornithine decarboxylase 1

increases activity

ISO

mancozeb results in increased activity of ODC1 protein

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

8-oxoguanine DNA glycosylase

multiple interactions
decreases expression

ISO

lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA]

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604

G

olfactory receptor family 1 subfamily S member 2

increases expression

ISO

mancozeb results in increased expression of OR1S1 mRNA

NCBI chr 1:220,338,536...220,339,483
Ensembl chr 1:220,338,530...220,339,483

G

Parkinsonism associated deglycase

multiple interactions

ISO

mancozeb results in decreased activity of and results in increased oxidation of PARK7 protein

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

protocadherin beta 20

decreases expression

ISO

mancozeb results in decreased expression of PCDHB14 mRNA

NCBI chr18:29,485,888...29,489,282
Ensembl chr18:29,454,999...29,489,427

G

peroxiredoxin 2

increases expression

ISO

mancozeb results in increased expression of PRDX2 protein

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

prolactin

multiple interactions
increases expression

ISO

[mancozeb co-treated with imidacloprid] results in increased expression of PRL protein
mancozeb results in increased expression of PRL mRNA

PMID:24530807 PMID:33396126

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prostaglandin E synthase

increases expression
decreases expression
multiple interactions

ISO

mancozeb results in increased expression of PTGES mRNA
mancozeb results in decreased expression of PTGES protein
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]

PMID:27235710 PMID:32446389

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin E synthase 3

decreases expression

ISO

mancozeb results in decreased expression of PTGES3 mRNA

NCBI chr 7:1,075,230...1,092,363
Ensembl chr 7:1,075,227...1,092,695

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

mancozeb results in increased expression of PTGS2 protein

PMID:21375462 PMID:32446389

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2 beta

multiple interactions

ISO

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

parvalbumin

increases expression

ISO

mancozeb results in increased expression of PVALB protein

NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
affects localization
multiple interactions

ISO

mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]

PMID:16112155 PMID:21375462 PMID:27235710

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

S100 calcium binding protein A6

increases expression

ISO

mancozeb results in increased expression of S100A6 protein

NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762

G

S100 calcium binding protein A9

increases expression

ISO

mancozeb results in increased expression of S100A9 protein

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

scleraxis bHLH transcription factor

decreases expression

ISO

mancozeb results in decreased expression of SCX mRNA

NCBI chr 7:110,056,897...110,059,283
Ensembl chr 7:110,054,601...110,061,438

G

succinate dehydrogenase complex subunit C

decreases expression

ISO

mancozeb results in decreased expression of SDHC mRNA

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044

G

septin 11

increases expression

ISO

mancozeb results in increased expression of SEPTIN11 mRNA

NCBI chr14:15,119,760...15,275,222
Ensembl chr14:15,128,951...15,275,200

G

serpin family F member 1

decreases expression

ISO

mancozeb results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898

G

sirtuin 1

decreases activity

ISO

mancozeb results in decreased activity of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

sirtuin 2

decreases activity

ISO

mancozeb results in decreased activity of SIRT2 protein

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499

G

sirtuin 3

decreases activity

ISO

mancozeb results in decreased activity of SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

solute carrier family 14 member 1 (Kidd blood group)

decreases expression

ISO

mancozeb results in decreased expression of SLC14A1 mRNA

NCBI chr18:73,840,568...73,883,925
Ensembl chr18:73,840,569...73,870,489

G

solute carrier family 5 member 5

multiple interactions

ISO

mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

small nucleolar RNA, C/D box 82

increases expression

ISO

mancozeb results in increased expression of SNORD82 mRNA

NCBI chr 9:94,452,486...94,452,557
Ensembl chr 9:94,452,486...94,452,557

G

superoxide dismutase 1

decreases expression
decreases activity

ISO

mancozeb results in decreased expression of SOD1 protein
mancozeb results in decreased activity of SOD1 protein

PMID:21375462 PMID:35617905

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sulfotransferase family 2B member 1

decreases expression

ISO

mancozeb results in decreased expression of SULT2B1 mRNA

NCBI chr 1:105,336,614...105,397,744
Ensembl chr 1:105,336,614...105,397,744

G

TEK receptor tyrosine kinase

increases activity

ISO

mancozeb results in increased activity of TEK protein

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

transforming growth factor beta 1 induced transcript 1

decreases expression

ISO

mancozeb results in decreased expression of TGFB1I1 mRNA

NCBI chr 1:192,258,992...192,265,903
Ensembl chr 1:192,258,598...192,265,903

G

tumor necrosis factor

multiple interactions

ISO

mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]

PMID:15742816 PMID:15893782 PMID:16112155

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

decreases expression
increases expression
multiple interactions

ISO

mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]

PMID:22369882 PMID:27235710

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

triosephosphate isomerase 1

increases expression

ISO

mancozeb results in increased expression of TPI1 protein

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

thyroid peroxidase

decreases activity

EXP

mancozeb results in decreased activity of TPO protein

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793

G

thyroid stimulating hormone subunit beta

multiple interactions

ISO

[mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

X-ray repair cross complementing 1

decreases expression
multiple interactions

ISO

mancozeb results in decreased expression of XRCC1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613

G

zinc finger protein 358

decreases expression

ISO

mancozeb results in decreased expression of ZNF358 mRNA

NCBI chr12:6,350,266...6,354,359
Ensembl chr12:6,350,067...6,354,897

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCB1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCB1 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of ABCB1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of ABCB1 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of ABCB1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCC1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of ABCC1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCC2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of ABCC2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCG2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of ABCG2 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of ABCG2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of ABCG2 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of ABCG2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of ABCG2 protein

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BAX protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BAX protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BAX mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BBC3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BBC3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL2, apoptosis regulator

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of BCL2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of BCL2 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of BCL2 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

baculoviral IAP repeat-containing 2

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

caspase 3

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of CASP3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of CASP3 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of CASP3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

cytochrome c, somatic

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of CYCS mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

glutathione S-transferase mu 1

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of GSTM1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of GSTM1 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

histone deacetylase 3

decreases activity

ISO

polymarcine results in decreased activity of HDAC3 protein

NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025

G

histone deacetylase 6

decreases activity

ISO

polymarcine results in decreased activity of HDAC6 protein

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

major vault protein

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in increased expression of MVP mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of MVP mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in increased expression of MVP mRNA

NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:191,025,268...191,052,873

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

sirtuin 1

decreases activity

ISO

polymarcine results in decreased activity of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

sirtuin 2

decreases activity

ISO

polymarcine results in decreased activity of SIRT2 protein

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499

G

sirtuin 3

decreases activity

ISO

polymarcine results in decreased activity of SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

solute carrier family 5 member 5

multiple interactions

ISO

polymarcine inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

tumor necrosis factor

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 10b

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of TNFRSF10A mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of TNFRSF10A mRNA

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

tumor protein p53

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of TP53 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of TP53 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

X-linked inhibitor of apoptosis

multiple interactions

ISO

[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in increased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Parkinsonism associated deglycase

decreases activity

ISO

propineb results in decreased activity of PARK7 protein

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
Zinc Acetate results in decreased expression of AGL mRNA

NCBI chr 2:207,389,949...207,445,959
Ensembl chr 2:207,389,949...207,445,724

G

aminolevulinate dehydratase

multiple interactions
increases activity

EXP

[Zinc Acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]

NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,558,347...40,586,714

G

aldehyde dehydrogenase 6 family, member A1

multiple interactions
increases expression

ISO

Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]
Zinc Acetate results in increased expression of ALDH6A1 mRNA

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743

G

Rho GTPase activating protein 17

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA
Zinc Acetate results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:187,238,380...187,327,936

G

activating transcription factor 3

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

ATM serine/threonine kinase

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase copper transporting beta

increases response to substance
multiple interactions

ISO

ATP7B gene mutant form results in increased susceptibility to Zinc Acetate
[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

ATR serine/threonine kinase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA
Zinc Acetate results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

BTB domain and CNC homolog 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA
Zinc Acetate results in increased expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BAG cochaperone 3

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

Bcl-2 binding component 3

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein]

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

baculoviral IAP repeat-containing 5

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of BIRC5 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BCL2 interacting protein 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA
Zinc Acetate results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA
Zinc Acetate results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

basigin

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BSG protein]

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005

G

calnexin

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 3

multiple interactions
decreases expression

EXP
ISO

[Taurine co-treated with Zinc Acetate] inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Zinc Acetate results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA

PMID:16357179 PMID:26335259

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

core-binding factor subunit beta

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA

NCBI chr19:49,955,133...50,002,661
Ensembl chr19:49,959,096...50,002,657

G

cyclin B1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCNB1 protein]

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin J

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
Zinc Acetate results in decreased expression of CCNJ mRNA

NCBI chr 1:249,608,991...249,626,798
Ensembl chr 1:249,608,969...249,626,794

G

cell division cycle 16

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA
Zinc Acetate results in decreased expression of CDC16 mRNA

NCBI chr16:82,475,234...82,498,797
Ensembl chr16:82,474,523...82,498,765

G

cell division cycle 25C

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA
Zinc Acetate results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cell division cycle 27

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA

NCBI chr10:89,900,676...89,949,770
Ensembl chr10:89,900,684...89,949,770

G

cell division cycle 5-like

decreases expression
multiple interactions

ISO

Zinc Acetate results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA

NCBI chr 9:23,062,397...23,100,901
Ensembl chr 9:23,062,205...23,100,899

G

cell division cycle associated 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA
Zinc Acetate results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524
Ensembl chr15:46,071,360...46,116,639

G

cyclin-dependent kinase 19

increases expression

ISO

Zinc Acetate results in increased expression of CDK19 mRNA

NCBI chr20:45,324,911...45,465,121
Ensembl chr20:45,324,862...45,465,121

G

cyclin dependent kinase 2

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA
Zinc Acetate results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cystathionine gamma-lyase

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

cullin 3

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA
Zinc Acetate results in decreased expression of CUL3 mRNA

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427

G

C-X-C motif chemokine ligand 1

increases secretion

ISO

Zinc Acetate results in increased secretion of CXCL1 protein

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 3

increases secretion

ISO

Zinc Acetate results in increased secretion of CXCL1 protein

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome b5 reductase 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CYB5R1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA

NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465

G

death-associated protein kinase 3

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of DAPK3 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]

NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

death effector domain containing 2

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of DEDD2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]

NCBI chr 1:89,916,906...89,934,663
Ensembl chr 1:89,919,524...89,936,804

G

DNA fragmentation factor subunit beta

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA
Zinc Acetate results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

7-dehydrocholesterol reductase

decreases expression

ISO

Zinc Acetate results in decreased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

DnaJ heat shock protein family (Hsp40) member B1

decreases expression
multiple interactions

ISO

Zinc Acetate results in decreased expression of DNAJB1 mRNA
motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA
Zinc Acetate results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA
Zinc Acetate results in increased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

dopamine receptor D1

multiple interactions

EXP

Zinc Acetate inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions

EXP

Zinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dual specificity phosphatase 1

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in increased expression of DUSP1 mRNA; [Taurine co-treated with Zinc Acetate] results in increased expression of DUSP1 protein

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

E2F transcription factor 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of E2F1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA
Zinc Acetate results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

egl-9 family hypoxia-inducible factor 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA

NCBI chr19:69,765,276...69,804,681

G

elongator acetyltransferase complex subunit 1

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA
Zinc Acetate results in decreased expression of ELP1 mRNA

NCBI chr 5:76,248,545...76,300,985
Ensembl chr 5:76,248,550...76,300,985

G

enolase 1

increases expression

ISO

Zinc Acetate results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

Fas associated via death domain

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA
Zinc Acetate results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas apoptotic inhibitory molecule

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA
Zinc Acetate results in decreased expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

family with sequence similarity 162, member A

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA
Zinc Acetate results in increased expression of FAM162A mRNA

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

fatty acid synthase

decreases expression

ISO

Zinc Acetate results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

forkhead box O3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA
Zinc Acetate results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of GCLM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutaminase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA
Zinc Acetate results in decreased expression of GLS mRNA

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861

G

G protein-coupled receptor 146

increases expression

ISO

Zinc Acetate results in increased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

glutamic--pyruvic transaminase 2

increases expression

ISO

Zinc Acetate results in increased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917

G

glutathione peroxidase 1

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions
decreases activity
increases expression

ISO
EXP

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA
Zinc Acetate results in decreased activity of GSR protein
Zinc Acetate results in increased expression of GSR mRNA

PMID:16357179 PMID:17382203

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

general transcription factor IIIC subunit 2

increases expression

ISO

Zinc Acetate results in increased expression of GTF3C2 mRNA

NCBI chr 6:30,913,263...30,941,305
Ensembl chr 6:30,923,106...30,940,465

G

HMG-box transcription factor 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of HBP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:54,256,864...54,283,366

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
Zinc Acetate results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hypoxia inducible lipid droplet-associated

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA
Zinc Acetate results in increased expression of HILPDA mRNA

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423

G

homeodomain interacting protein kinase 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]

NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:193,937,261...193,975,164

G

helicase-like transcription factor

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
Zinc Acetate results in decreased expression of HLTF mRNA

NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:104,478,772...104,538,818

G

heme oxygenase 1

multiple interactions
increases expression

ISO
EXP

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
[Taurine co-treated with Zinc Acetate] results in increased expression of HMOX1 protein

PMID:16357179 PMID:26335259

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

harakiri, BCL2 interacting protein

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of HRK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561

G

heat shock protein 90 alpha family class B member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
Zinc Acetate results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA]

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA]

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA
Zinc Acetate results in increased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 4 like

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA
Zinc Acetate results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:125,668,236...125,720,986

G

heat shock protein family B (small) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family H (Hsp110) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

intercellular adhesion molecule 1

multiple interactions
increases expression

ISO

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]; [Zinc Acetate results in increased phosphorylation of NFKBIA protein] inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA
Zinc Acetate results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA
Zinc Acetate results in increased expression of IKBKE mRNA

NCBI chr13:45,264,404...45,290,737
Ensembl chr13:45,264,412...45,289,396

G

interleukin 10

increases secretion

ISO

Zinc Acetate results in increased secretion of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in decreased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases secretion

ISO

Zinc Acetate results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7

increases secretion

ISO

Zinc Acetate results in increased secretion of IL7 protein

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389

G

interferon regulatory factor 2 binding protein 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA
Zinc Acetate results in increased expression of IRF2BP2 mRNA

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA
Zinc Acetate results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

lysine demethylase 3A

increases expression

ISO

Zinc Acetate results in increased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

mitogen-activated protein kinase 8

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK8 protein modified form

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK9 protein modified form

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microtubule-associated protein tau

multiple interactions

ISO

[Zinc Acetate results in decreased abundance of Copper] which results in decreased phosphorylation of MAPT protein

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

MDM2 proto-oncogene

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MOB kinase activator 1A

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]

NCBI chr 4:117,389,278...117,406,255
Ensembl chr 4:117,389,186...117,406,250

G

metallothionein 1, pseudogene 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of MT1E mRNA
Zinc Acetate results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

increases expression

ISO

Zinc Acetate results in increased expression of MT1 protein

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of MT2 mRNA; Zinc Acetate results in increased expression of MT2 protein
Zinc Acetate results in increased expression of MT2A mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]

PMID:8876661 PMID:15306638 PMID:16357179

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

metallothionein 2, pseudogene 1

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1HL1 mRNA]

NCBI chr20:3,163,749...3,164,121

G

MYD88, innate immune signal transduction adaptor

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of CXCL8 protein]; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]
Zinc Acetate results in decreased expression of MYD88 mRNA

PMID:16357179 PMID:24080332

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NAD kinase

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA
Zinc Acetate results in increased expression of NADK mRNA

NCBI chr 5:171,427,973...171,458,586
Ensembl chr 5:171,428,000...171,458,579

G

neurofibromin 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of NF1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

NFKB inhibitor alpha

increases degradation
multiple interactions
increases phosphorylation

ISO

Zinc Acetate results in increased degradation of NFKBIA protein
[Zinc Acetate results in increased phosphorylation of NFKBIA protein] inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]

PMID:21974847 PMID:24080332

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nischarin

decreases expression

ISO

Zinc Acetate results in decreased expression of NISCH mRNA

NCBI chr16:6,370,809...6,407,104
Ensembl chr16:6,370,809...6,407,387

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group D, member 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

prolyl 4-hydroxylase subunit beta

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

programmed cell death 11

decreases expression

ISO

Zinc Acetate results in decreased expression of PDCD11 mRNA

NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336

G

programmed cell death 4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA
Zinc Acetate results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

programmed cell death 5

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA
Zinc Acetate results in decreased expression of PDCD5 mRNA

NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:97,442,755...97,449,844

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA
Zinc Acetate results in increased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA
Zinc Acetate results in increased expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

phosphofructokinase, muscle

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PFKM protein]

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

phosphoglycerate kinase 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

putative homeodomain transcription factor 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]

NCBI chr 4:15,107,341...15,222,683
Ensembl chr 4:15,107,373...15,222,692

G

protein inhibitor of activated STAT, 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]

NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:72,233,566...72,334,315

G

phosphoinositide-3-kinase interacting protein 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA
Zinc Acetate results in increased expression of PIK3IP1 mRNA

NCBI chr14:82,428,315...82,440,261
Ensembl chr14:82,428,248...82,440,260

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of PMAIP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
Zinc Acetate results in increased expression of PRKACB mRNA

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase C, delta

decreases expression

ISO

Zinc Acetate results in decreased expression of PRKCD mRNA

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase D2

decreases expression

ISO

Zinc Acetate results in decreased expression of PRKD2 mRNA

NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:86,642,629...86,670,675

G

protein kinase, DNA-activated, catalytic subunit

increases expression

ISO

Zinc Acetate results in increased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

peptidyl-tRNA hydrolase 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA
Zinc Acetate results in decreased expression of PTRH2 mRNA

NCBI chr10:72,002,450...72,012,606
Ensembl chr10:71,985,245...72,045,352

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTTG1 protein]

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

RB transcriptional corepressor 1

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA
Zinc Acetate results in decreased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RCC1 and BTB domain containing protein 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
Zinc Acetate results in decreased expression of RCBTB2 mRNA

NCBI chr15:54,729,367...54,774,004
Ensembl chr15:54,729,332...54,793,313

G

RELB proto-oncogene, NF-kB subunit

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA
Zinc Acetate results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

retinoid X receptor alpha

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SAMTOR mRNA
Zinc Acetate results in increased expression of SAMTOR mRNA

NCBI chr 4:42,847,720...42,911,546
Ensembl chr 4:42,836,172...42,917,567

G

selenoprotein W

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
Zinc Acetate results in increased expression of SELENOW mRNA

NCBI chr 1:85,727,631...85,732,703
Ensembl chr 1:85,727,632...85,732,703

G

sestrin 2

multiple interactions
increases expression

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
Zinc Acetate results in increased expression of SESN2 mRNA

PMID:16357179 PMID:20530418

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

solute carrier family 16 member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 16 member 3

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC16A3 protein]

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 16, member 6

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of SLC16A6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965

G

solute carrier family 1 member 4

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of SLC1A4 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 2 member 1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 30 member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA]

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 31 member 1

increases expression

ISO

Zinc Acetate results in increased expression of SLC31A1 mRNA

NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809

G

solute carrier family 38, member 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 10

affects expression
multiple interactions

ISO

Zinc Acetate affects the expression of SLC39A10 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:62,370,598...62,454,747

G

solute carrier family 39 member 14

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA
Zinc Acetate results in increased expression of SLC39A14 mRNA

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229

G

solute carrier family 39, member 9

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA
Zinc Acetate results in increased expression of SLC39A9 mRNA

NCBI chr 6:106,022,858...106,061,734
Ensembl chr 6:106,022,850...106,071,176

G

solute carrier family 3 member 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
Zinc Acetate results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 43 member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
Zinc Acetate results in increased expression of SLC43A1 mRNA

NCBI chr 3:90,327,250...90,353,438
Ensembl chr 3:90,327,149...90,353,438

G

solute carrier family 7 member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
Zinc Acetate results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030

G

solute carrier family 7 member 11

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA
Zinc Acetate results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA
Zinc Acetate results in decreased expression of SMARCA4 mRNA

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:28,443,810...28,535,070

G

SNF2 related chromatin remodeling ATPase 5

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA
Zinc Acetate results in decreased expression of SMARCA5 mRNA

NCBI chr19:44,172,465...44,208,967
Ensembl chr19:44,175,733...44,208,957

G

superoxide dismutase 1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

Sp1 transcription factor

increases expression

ISO

Zinc Acetate results in increased expression of SP1 mRNA

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

T-cell activation RhoGTPase activating protein

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA
Zinc Acetate results in increased expression of TAGAP mRNA

NCBI chr 1:49,575,750...49,584,747
Ensembl chr 1:49,575,750...49,583,838

G

transferrin receptor

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

TNF alpha induced protein 8

decreases expression
multiple interactions

ISO

Zinc Acetate results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA

NCBI chr18:45,370,334...45,486,036
Ensembl chr18:45,370,406...45,486,036

G

TNF receptor superfamily member 17

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
Zinc Acetate results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,808,023...4,813,857

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF superfamily member 8

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]

NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:82,266,436...82,292,858

G

TNFAIP3 interacting protein 2

decreases expression

ISO

Zinc Acetate results in decreased expression of TNIP2 mRNA

NCBI chr14:80,452,936...80,470,141
Ensembl chr14:80,452,845...80,470,992

G

tumor protein p53

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tribbles pseudokinase 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA
Zinc Acetate results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

thioredoxin reductase 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA
Zinc Acetate results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in increased expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

vascular endothelial growth factor A

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA
Zinc Acetate results in increased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

von Hippel-Lindau tumor suppressor

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of VHL mRNA
motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991

zinc dichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ABCB1 mRNA]
zinc chloride inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 6

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ABCB6 mRNA]

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

[sodium arsenite co-treated with zinc chloride] results in increased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

acetylcholinesterase

multiple interactions

EXP

[zinc chloride co-treated with Sodium Selenite] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased activity of ACHE protein]; [zinc chloride results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]

PMID:19429256 PMID:29233033 PMID:36646412

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

aconitase 2

multiple interactions

ISO

[Citric Acid co-treated with zinc chloride] results in decreased activity of ACO2 protein

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

actin, beta

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of ACTB mRNA

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

ADAM metallopeptidase domain 2

decreases expression

ISO

zinc chloride results in decreased expression of ADAM2 mRNA

NCBI chr15:44,418,191...44,459,570
Ensembl chr15:44,418,199...44,459,516

G

adhesion G protein-coupled receptor E1

multiple interactions
increases expression

ISO

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

adrenomedullin

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ADM mRNA]

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371

G

adenosine A1 receptor

multiple interactions

EXP

zinc chloride inhibits the reaction [N(6)-cyclohexyladenosine binds to ADORA1 protein]

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190

G

alpha-fetoprotein

decreases expression

ISO

zinc chloride results in decreased expression of AFP mRNA

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

argonaute RISC catalytic component 2

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:106,918,125...106,993,980

G

adenylate kinase 4

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of AK4 mRNA]

NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

ISO

zinc chloride results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aminolevulinate dehydratase

multiple interactions

ISO
EXP

[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury; zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]
lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]; zinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of ALAD protein]

PMID:2061546 PMID:14615064 PMID:22413763 PMID:24619859 PMID:24679358

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

aldolase, fructose-bisphosphate A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ALDOA mRNA]

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

aldolase, fructose-bisphosphate C

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ALDOC mRNA]

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases activity

ISO
EXP

[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of ALPL mRNA
zinc chloride results in increased activity of ALPL protein
Cadmium inhibits the reaction [zinc chloride results in increased activity of ALPL protein]; zinc chloride inhibits the reaction [Cadmium results in decreased activity of ALPL protein]; zinc chloride inhibits the reaction [Tamoxifen results in increased activity of ALPL protein]

PMID:19913120 PMID:26214600 PMID:31532279

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

angiogenin

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANG mRNA]

NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106

G

angiopoietin-like 4

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANGPTL4 mRNA]

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

ankyrin repeat domain 37

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANKRD37 mRNA]

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545

G

ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ANKZF1 mRNA]

NCBI chr 9:84,136,862...84,143,830
Ensembl chr 9:84,136,862...84,145,091

G

aquaporin 7

increases expression

ISO

zinc chloride results in increased expression of AQP7 mRNA

NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:60,967,558...60,982,618

G

aquaporin 9

decreases expression

ISO

zinc chloride results in decreased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

androgen receptor

multiple interactions

EXP

Androgens inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]]; zinc chloride inhibits the reaction [Androgens binds to AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

arginase 2

increases expression

ISO

zinc chloride results in increased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:103,668,988...103,694,375

G

arrestin, beta 2

affects localization

ISO

zinc chloride affects the localization of ARRB2 protein

NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487

G

activating transcription factor 2

multiple interactions

ISO

[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein]

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

activating transcription factor 4

decreases expression

ISO

zinc chloride results in decreased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

ATPase H+ transporting V1 subunit B2

decreases expression

ISO

zinc chloride results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ATPase copper transporting beta

decreases expression
increases expression

ISO

zinc chloride results in decreased expression of ATP7B mRNA
zinc chloride results in increased expression of ATP7B mRNA

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

BAG cochaperone 3

increases expression
multiple interactions

ISO

zinc chloride results in increased expression of BAG3 mRNA
zinc chloride results in increased expression of and affects the localization of BAG3 protein

PMID:12706811 PMID:16870260

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO
EXP

[Citric Acid co-treated with zinc chloride] results in increased expression of BAX protein
zinc chloride affects the reaction [Cadmium Chloride results in increased expression of BAX protein]
zinc chloride promotes the reaction [Doxorubicin results in increased expression of BAX mRNA]

PMID:16624386 PMID:19714248 PMID:28390674

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

multiple interactions

ISO

zinc chloride promotes the reaction [Doxorubicin results in increased expression of BBC3 mRNA]

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL2, apoptosis regulator

multiple interactions

ISO

[Citric Acid co-treated with zinc chloride] results in decreased expression of BCL2 protein; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 mRNA]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BCL2 protein]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BCL2 mRNA]
zinc chloride inhibits the reaction [Doxorubicin results in increased expression of BCL2 mRNA]

PMID:16624386 PMID:17786326 PMID:19714248

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

increases expression

ISO

zinc chloride results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

multiple interactions

ISO

[Citric Acid co-treated with zinc chloride] results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

brain-derived neurotrophic factor

multiple interactions

EXP

zinc chloride affects the reaction [Cadmium Chloride affects the expression of BDNF mRNA]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

bone gamma-carboxyglutamate protein

multiple interactions

ISO

[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of BGLAP mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of BGLAP mRNA

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

basic helix-loop-helix family, member e40

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BHLHE40 mRNA]

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

BCL2 interacting protein 3 like

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of BNIP3L mRNA]

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

BOP1 ribosomal biogenesis factor

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of BOP1 mRNA]

NCBI chr 7:110,052,716...110,076,529
Ensembl chr 7:110,052,720...110,076,529

G

complement C3

increases expression

ISO

zinc chloride results in increased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

carbonic anhydrase 13

increases expression

ISO

zinc chloride results in increased expression of CAR13 mRNA

NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763

G

carbonic anhydrase 9

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626

G

calcium voltage-gated channel subunit alpha1 H

decreases activity
multiple interactions

ISO

zinc chloride results in decreased activity of CACNA1H protein
zinc chloride inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]

NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771

G

caldesmon 1

increases expression

ISO

zinc chloride results in increased expression of CALD1 mRNA

NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085

G

caspase 12

multiple interactions

ISO

[Citric Acid co-treated with zinc chloride] results in increased activity of CASP12 protein

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

multiple interactions

ISO
EXP

[Citric Acid co-treated with zinc chloride] results in increased activity of CASP3 protein
[zinc chloride co-treated with lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of CASP3 protein; zinc chloride inhibits the reaction [Tamoxifen results in increased activity of CASP3 protein]

PMID:16624386 PMID:31532279 PMID:36646412

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 mRNA]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
increases expression
increases activity

EXP
ISO

[zinc chloride co-treated with Sodium Selenite] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased activity of CAT protein]; zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]; zinc chloride inhibits the reaction [Tamoxifen results in decreased activity of CAT protein]
zinc chloride results in increased expression of CAT mRNA
zinc chloride results in increased activity of CAT protein

PMID:9330853 PMID:19429256 PMID:23726800 PMID:31532279 PMID:36646412

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 11

increases expression

ISO

zinc chloride results in increased expression of CCL11 mRNA

NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575

G

C-C motif chemokine ligand 17

decreases expression

ISO

zinc chloride results in decreased expression of CCL17 mRNA

NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895

G

C-C motif chemokine ligand 19

decreases expression

ISO

zinc chloride results in decreased expression of CCL19 mRNA

NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022

G

C-C motif chemokine ligand 20

increases expression

ISO

zinc chloride results in increased expression of CCL20 mRNA

PMID:19428942 PMID:21540303 PMID:27427241

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 24

decreases expression

ISO

zinc chloride results in decreased expression of CCL24 mRNA

NCBI chr12:26,737,423...26,741,420
Ensembl chr12:26,737,439...26,750,924

G

C-C motif chemokine ligand 26

increases expression

ISO

zinc chloride results in increased expression of CCL26 mRNA

NCBI chr12:26,745,972...26,750,924

G

C-C motif chemokine ligand 9

decreases expression

ISO

zinc chloride results in decreased expression of CCL15 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877

G

cellular communication network factor 1

increases expression

ISO

zinc chloride results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

increases expression

ISO

zinc chloride results in increased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin B1

increases expression

ISO

zinc chloride results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin G1

multiple interactions

ISO

zinc chloride affects the reaction [Cadmium Chloride results in increased expression of CCNG1 mRNA]

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin G2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CCNG2 mRNA]

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206

G

C-C motif chemokine receptor 6

decreases expression

ISO

zinc chloride results in decreased expression of CCR6 mRNA

NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059

G

C-C motif chemokine receptor 8

decreases expression

ISO

zinc chloride results in decreased expression of CCR8 mRNA

NCBI chr 8:128,703,966...128,705,926
Ensembl chr 8:128,702,349...128,705,955

G

CD86 molecule

decreases expression

ISO

zinc chloride results in decreased expression of CD86 protein

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

CD9 molecule

increases expression

ISO

zinc chloride results in increased expression of CD9 mRNA

NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444

G

cadherin 17

decreases expression

ISO

zinc chloride results in decreased expression of CDH17 mRNA

NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Citric Acid co-treated with zinc chloride] results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases expression

ISO

zinc chloride results in decreased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2B

decreases expression

ISO

zinc chloride results in decreased expression of CDKN2B mRNA

NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855

G

CEA cell adhesion molecule 6

increases expression

ISO

zinc chloride results in increased expression of CEACAM6 mRNA

NCBI chr 1:89,544,415...89,562,552
Ensembl chr 1:89,544,400...89,562,552

G

CF transmembrane conductance regulator

increases expression

ISO

zinc chloride results in increased expression of CFTR mRNA

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

checkpoint kinase 1

increases expression

ISO

zinc chloride results in increased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CITED2 mRNA]

NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782

G

collagen type I alpha 1 chain

multiple interactions

ISO

[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

copper metabolism domain containing 1

multiple interactions

EXP

[COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein; [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein

NCBI chr14:101,081,667...101,185,738
Ensembl chr14:101,081,667...101,185,639

G

cytochrome c oxidase copper chaperone COX17

decreases expression

ISO

zinc chloride results in decreased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

ceruloplasmin

increases expression

ISO

zinc chloride results in increased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

carbamoyl-phosphate synthase 1

increases expression

ISO

zinc chloride results in increased expression of CPS1 mRNA

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734

G

C-reactive protein

increases expression

ISO

zinc chloride results in increased expression of CRP mRNA

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

colony stimulating factor 2

increases expression
multiple interactions

ISO

zinc chloride results in increased expression of CSF2 mRNA
zinc chloride results in increased expression of CSF2 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]

PMID:18509044 PMID:21540303 PMID:27427241

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

cysteine and glycine-rich protein 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of CSRP2 mRNA]

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

C-X-C motif chemokine ligand 1

increases expression

ISO

zinc chloride results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 11

increases expression

ISO

zinc chloride results in increased expression of CXCL11 mRNA

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567

G

C-X-C motif chemokine ligand 13

decreases expression

ISO

zinc chloride results in decreased expression of CXCL13 mRNA

NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920

G

C-X-C motif chemokine ligand 14

increases expression

ISO

zinc chloride results in increased expression of CXCL14 mRNA

NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,323,143...8,331,172

G

C-X-C motif chemokine ligand 3

increases expression

ISO

zinc chloride results in increased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine ligand 6

decreases expression

ISO

zinc chloride results in decreased expression of CXCL6 mRNA

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases stability
multiple interactions

ISO

zinc chloride results in increased stability of CYP1A1 mRNA; zinc chloride results in increased stability of CYP1A1 protein
zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

decapping mRNA 1B

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA

NCBI chr 4:154,030,181...154,068,038
Ensembl chr 4:154,030,690...154,068,035

G

DExD-box helicase 21

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of DDX21 mRNA]

NCBI chr20:31,077,044...31,097,238
Ensembl chr20:31,077,045...31,097,238

G

DENN domain containing 2B

increases expression

ISO

zinc chloride results in increased expression of DENND2B mRNA

NCBI chr 1:172,978,895...173,129,623
Ensembl chr 1:172,978,895...173,129,810

G

dehydrogenase/reductase 2

increases expression

ISO

zinc chloride results in increased expression of DHRS2 mRNA

NCBI chr15:32,658,855...32,673,591
Ensembl chr15:32,659,223...32,673,588

G

dicer 1 ribonuclease III

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein

NCBI chr 6:129,392,298...129,457,252
Ensembl chr 6:129,396,014...129,457,252

G

delta like canonical Notch ligand 4

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in decreased expression of DLL4 mRNA

NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763

G

dopamine receptor D1

multiple interactions

EXP

zinc chloride inhibits the reaction [ecopipam binds to DRD1 protein]; zinc chloride inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions

EXP

zinc chloride inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]; zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

drosha ribonuclease III

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein

NCBI chr 2:63,591,885...63,703,688
Ensembl chr 2:63,591,968...63,703,687

G

dual oxidase 1

multiple interactions

ISO

DUOX1 protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein]

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:129,714,149...129,749,187

G

epidermal growth factor receptor

increases phosphorylation

ISO

zinc chloride results in increased phosphorylation of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EGLN1 mRNA]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]

PMID:16579968 PMID:22202117

NCBI chr19:69,765,276...69,804,681

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

ETS transcription factor ELK1

multiple interactions
increases activity

EXP

zinc chloride results in increased phosphorylation of and results in increased activity of ELK1 protein
zinc chloride results in increased activity of ELK1 protein

PMID:16960431 PMID:20412391

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

enolase 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ENO2 mRNA]

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

erythropoietin

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

ISO

zinc chloride results in decreased expression of F2RL2 mRNA

NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:28,706,501...28,712,473

G

fatty acid binding protein 1

decreases expression

ISO

zinc chloride results in decreased expression of FABP1 mRNA

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113

G

family with sequence similarity 162, member A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of FAM162A mRNA]

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

fatty acid synthase

decreases expression

ISO

zinc chloride results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

zinc chloride results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box A2

decreases expression

ISO

zinc chloride results in decreased expression of FOXA2 mRNA

NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:155,923,307...155,928,757

G

forkhead box D1

increases expression

ISO

zinc chloride results in increased expression of FOXD1 mRNA

NCBI chr 2:31,436,802...31,439,222
Ensembl chr 2:31,436,813...31,439,399

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

EXP

zinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of G6PC1 protein]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucose-6-phosphate dehydrogenase

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

increases expression

ISO

zinc chloride results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

1,4-alpha-glucan branching enzyme 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GBE1 mRNA]

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

ISO

zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA]
zinc chloride results in increased expression of GCLC mRNA

PMID:18385089 PMID:33645215

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

gap junction protein, alpha 1

multiple interactions

ISO

zinc chloride inhibits the reaction [Vincristine results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

zinc chloride inhibits the reaction [Tamoxifen results in increased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

ISO
EXP

[zinc chloride results in increased abundance of Zinc] which results in increased activity of GPT protein
zinc chloride inhibits the reaction [Tamoxifen results in increased activity of GPT protein]

PMID:31532279 PMID:36450499

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions

EXP

zinc chloride inhibits the reaction [Tamoxifen results in decreased activity of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

increases expression

ISO

zinc chloride results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutamate ionotropic receptor kainate type subunit 2

increases expression

ISO

zinc chloride results in increased expression of GRIK2 mRNA

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:53,716,090...54,415,202

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

EXP

AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2A protein]; zinc chloride results in increased expression of and results in increased phosphorylation of GRIN2A protein

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

EXP

AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of GRIN2B protein]; zinc chloride results in increased expression of and results in increased phosphorylation of GRIN2B protein

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate metabotropic receptor 5

multiple interactions
increases expression

EXP

Copper inhibits the reaction [zinc chloride results in increased expression of GRM5 protein]

NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649

G

glutathione-disulfide reductase

multiple interactions

ISO
EXP

[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to zinc chloride
zinc chloride inhibits the reaction [Cadmium Chloride results in increased activity of GSR protein]; zinc chloride inhibits the reaction [Copper results in decreased activity of GSR protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]

PMID:12632252 PMID:19429256 PMID:20600438 PMID:23726800

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase pi 1

multiple interactions

EXP

[Cadmium Chloride co-treated with zinc chloride] results in increased expression of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glycogen synthase 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GYS1 mRNA]

NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:105,051,961...105,072,419

G

H2A.X variant histone

increases expression

ISO

zinc chloride results in increased expression of H2AX mRNA

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

host cell factor C1 regulator 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HCFC1R1 mRNA]

NCBI chr10:13,209,757...13,211,445
Ensembl chr10:13,209,558...13,211,443

G

histone deacetylase 1

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in decreased expression of HDAC1 mRNA

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

helicase, lymphoid specific

increases expression

ISO

zinc chloride results in increased expression of HELLS mRNA

NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228

G

hephaestin

decreases expression

ISO

zinc chloride results in decreased expression of HEPH mRNA

NCBI chr X:65,160,628...65,412,457
Ensembl chr X:65,305,773...65,412,453

G

hexosaminidase subunit beta

multiple interactions

EXP

zinc chloride inhibits the reaction [2-phenylphenol results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [bitertanol results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [Butylated Hydroxyanisole results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [Butylated Hydroxytoluene results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [butylparaben results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [EPN oxon results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [Permethrin results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [prothiophos results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [pyridaben results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [salinomycin results in increased secretion of HEXB protein]; zinc chloride inhibits the reaction [terbufos results in increased secretion of HEXB protein]

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression
affects splicing

ISO

Cycloheximide inhibits the reaction [zinc chloride results in increased expression of HIF1A protein alternative form]; zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
[Doxorubicin co-treated with zinc chloride] results in decreased expression of HIF1A mRNA
zinc chloride results in increased expression of HIF1A mRNA; zinc chloride results in increased expression of HIF1A mRNA alternative form; zinc chloride results in increased expression of HIF1A protein alternative form
zinc chloride affects the splicing of HIF1A mRNA

PMID:11090055 PMID:11739637 PMID:16579968 PMID:19714248

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hypoxia inducible lipid droplet-associated

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HILPDA mRNA]

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423

G

homeodomain interacting protein kinase 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]]; zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein]; zinc chloride inhibits the reaction [Oxygen deficiency results in decreased expression of HIPK2 protein]
[Doxorubicin co-treated with zinc chloride] results in increased expression of HIPK2 mRNA

NCBI chr 4:68,399,358...68,586,404
Ensembl chr 4:68,369,099...68,586,108

G

hexokinase 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HK2 mRNA]

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

heme oxygenase 1

increases expression
multiple interactions

ISO
EXP

zinc chloride results in increased expression of HMOX1 mRNA; zinc chloride results in increased expression of HMOX1 protein
[zinc chloride co-treated with Sodium Selenite] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in decreased expression of HMOX1 protein]
HMOX1 enhancer affects the reaction [zinc chloride results in increased expression of HMOX1 mRNA]
zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]

PMID:7538129 PMID:16870260 PMID:22202117 PMID:27427241 PMID:33645215 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO

zinc chloride results in increased expression of HSPA1A mRNA

PMID:12085988 PMID:16870260

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

increases expression

ISO

zinc chloride results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

ISO

zinc chloride results in increased expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family D (Hsp60) member 1

increases expression

EXP

zinc chloride results in increased expression of HSPD1 protein

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

interferon gamma

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in decreased expression of IFNG mRNA; zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]

PMID:8975779 PMID:31588059

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases expression

ISO

zinc chloride results in decreased expression of IKBKB mRNA

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

increases expression

ISO

zinc chloride results in increased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 10 receptor subunit beta

decreases expression

ISO

zinc chloride results in decreased expression of IL10RB mRNA

NCBI chr11:44,132,471...44,154,062
Ensembl chr11:44,132,189...44,154,053

G

interleukin 12B

decreases expression

ISO

zinc chloride results in decreased expression of IL12B mRNA

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 18 receptor 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of IL18R1 mRNA]

NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:50,223,200...50,257,367

G

interleukin 1 alpha

increases expression
multiple interactions

ISO

zinc chloride results in increased expression of IL1A protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
zinc chloride inhibits the reaction [Tamoxifen results in increased expression of IL1B protein]
zinc chloride results in increased expression of IL1B mRNA
zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:9138684 PMID:18509044 PMID:19130485 PMID:27427241 PMID:31532279

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

increases expression

ISO

zinc chloride results in increased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 1 receptor antagonist

increases expression

ISO

zinc chloride results in increased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 3

multiple interactions
increases expression

ISO

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL3 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810

G

interleukin 36 receptor antagonist

decreases expression

ISO

zinc chloride results in decreased expression of IL36RN mRNA

NCBI chr 3:27,442,679...27,449,306
Ensembl chr 3:27,442,709...27,449,306

G

interleukin 6

increases secretion
multiple interactions
increases expression

ISO
EXP

zinc chloride results in increased secretion of IL6 protein
zinc chloride inhibits the reaction [Sodium Selenite promotes the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of IL6 protein]]; zinc chloride inhibits the reaction [Tamoxifen results in increased expression of IL6 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]; RELA protein affects the reaction [zinc chloride results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]
zinc chloride results in increased expression of IL6 mRNA

PMID:21842098 PMID:27427241 PMID:31532279 PMID:36646412

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin induced gene 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of INSIG2 mRNA]

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

insulin receptor

increases phosphorylation

ISO

zinc chloride results in increased phosphorylation of INSR protein

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

iron responsive element binding protein 2

increases expression

ISO

zinc chloride results in increased expression of IREB2 mRNA

NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520

G

integrin subunit beta 6

increases expression

ISO

zinc chloride results in increased expression of ITGB6 mRNA

NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

ISO

zinc chloride results in increased expression of JUN mRNA
[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [zinc chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]

PMID:11306679 PMID:19000923 PMID:21540303 PMID:30768131 PMID:33645215

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

zinc chloride results in increased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

lysine acetyltransferase 5

multiple interactions

ISO

zinc chloride affects the reaction [4-aminophenylarsenoxide binds to KAT5 protein]

NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:212,325,090...212,332,587

G

lysine demethylase 3A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of KDM3A mRNA]

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

lysine demethylase 4B

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of KDM4B mRNA]

NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,245,899...1,324,384

G

Kelch-like ECH-associated protein 1

affects folding
multiple interactions

ISO

zinc chloride affects the folding of KEAP1 protein
zinc chloride promotes the reaction [KEAP1 protein binds to KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

kinesin family member 5A

multiple interactions
decreases activity

ISO

Adenosine Triphosphate inhibits the reaction [zinc chloride results in decreased activity of KIF5A protein]; Magnesium Chloride affects the reaction [zinc chloride results in decreased activity of KIF5A protein]

NCBI chr 7:64,937,210...64,974,339
Ensembl chr 7:64,934,740...64,978,272

G

large tumor suppressor kinase 1

decreases phosphorylation

ISO

zinc chloride results in decreased phosphorylation of LATS1 protein

NCBI chr 1:3,980,801...4,014,029
Ensembl chr 1:3,980,544...4,014,029

G

leptin

increases expression

ISO

zinc chloride results in increased expression of LEP mRNA

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

LIM and calponin homology domains 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of LIMCH1 mRNA]

NCBI chr14:41,466,433...41,779,477
Ensembl chr14:41,466,433...41,778,837

G

lymphotoxin alpha

decreases expression
increases expression

ISO

zinc chloride results in decreased expression of LTA mRNA
zinc chloride results in increased expression of LTA mRNA

PMID:19428942 PMID:21540303

NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533

G

leukotriene B4 receptor

decreases expression

ISO

zinc chloride results in decreased expression of LTB4R mRNA

NCBI chr15:33,233,120...33,235,636
Ensembl chr15:33,232,820...33,235,637

G

MAF bZIP transcription factor F

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of MAFF mRNA]

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAF bZIP transcription factor G

increases expression

ISO

zinc chloride results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

mastermind-like transcriptional coactivator 1

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of MAML1 mRNA

NCBI chr10:35,089,715...35,124,100
Ensembl chr10:35,089,715...35,124,100

G

mitogen activated protein kinase kinase 4

increases activity

ISO

zinc chloride results in increased activity of MAP2K4 protein

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions
increases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein]

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen activated protein kinase 1

multiple interactions
increases activity
increases phosphorylation

EXP
ISO

N,N'-diphenyl-4-phenylenediamine inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK1 protein]; zinc chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein
zinc chloride results in increased activity of MAPK1 protein

PMID:11306679 PMID:11551972 PMID:16960431 PMID:20412391

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

EXP

1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; N,N'-diphenyl-4-phenylenediamine inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; Vanadates promotes the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]; zinc chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein

PMID:16960431 PMID:20412391 PMID:21575692

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein]; [[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]; RAC1 protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein]; zinc chloride inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; zinc chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein

PMID:11306679 PMID:20423716 PMID:30768131

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

zinc chloride inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

minichromosome maintenance complex component 3

increases expression

ISO

zinc chloride results in increased expression of MCM3 mRNA

NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746

G

macrophage migration inhibitory factor

decreases expression

ISO

zinc chloride results in decreased expression of MIF mRNA

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

microRNA 130a

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA

NCBI chr 3:90,229,228...90,229,315

G

microRNA 223

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA

NCBI chr X:65,151,383...65,151,492
Ensembl chr X:65,151,383...65,151,492

G

microRNA 29a

multiple interactions

ISO

[Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA

NCBI chr 4:60,617,955...60,618,042

G

matrix metallopeptidase 2

multiple interactions

ISO

zinc chloride inhibits the reaction [Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 7

decreases expression

ISO

zinc chloride results in decreased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

metallothionein 1, pseudogene 3

increases expression

ISO

zinc chloride results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

multiple interactions
affects response to substance
affects binding
increases expression
decreases expression

EXP
ISO

zinc chloride promotes the reaction [Glucose results in increased expression of MT1A mRNA]
MT1 affects the susceptibility to zinc chloride
zinc chloride binds to MT1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; bisindolylmaleimide I inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]]; Genistein inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Sodium Selenite inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]
zinc chloride results in increased expression of MT1 mRNA; zinc chloride results in increased expression of MT1 protein
zinc chloride results in decreased expression of MT1 protein
zinc chloride results in increased expression of MT1A mRNA
NF2 protein affects the reaction [zinc chloride results in increased expression of MT1A mRNA]; XMU-MP-1 promotes the reaction [zinc chloride results in increased expression of MT1A mRNA]
zinc chloride results in increased expression of MT1A mRNA; zinc chloride results in increased expression of MT1A protein

PMID:3422486 PMID:8928928 PMID:11551972 PMID:14998373 PMID:15288509 More...

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

multiple interactions
affects binding
affects response to substance
increases expression

ISO
EXP

[zinc chloride co-treated with pyrithione zinc] results in increased expression of MT2A mRNA; Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]
zinc chloride promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]
zinc chloride binds to MT2 protein
MT2 affects the susceptibility to zinc chloride
zinc chloride results in increased expression of MT2 mRNA; zinc chloride results in increased expression of MT2 protein
zinc chloride results in increased expression of MT2A mRNA; zinc chloride results in increased expression of MT2A protein
zinc chloride promotes the reaction [Glucose results in increased expression of MT2A mRNA]

PMID:9138684 PMID:15288509 PMID:16842966 PMID:16870260 PMID:16987576 More...

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

metallothionein 2, pseudogene 1

increases expression

ISO

zinc chloride results in increased expression of MT1HL1 mRNA

NCBI chr20:3,163,749...3,164,121

G

metallothionein 3

increases expression

ISO

zinc chloride results in increased expression of MT3 mRNA

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

metastasis associated 1 family, member 2

decreases expression

ISO

zinc chloride results in decreased expression of MTA2 mRNA

NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062

G

metal-regulatory transcription factor 1

multiple interactions
affects localization
decreases expression

ISO

zinc chloride results in increased phosphorylation of and results in increased activity of MTF1 protein
MTF1 protein mutant form inhibits the reaction [zinc chloride promotes the reaction [MTF1 protein binds to MTF1 promoter]]; MTF1 protein mutant form inhibits the reaction [zinc chloride promotes the reaction [MTF1 protein binds to SLC30A2 promoter]]; zinc chloride promotes the reaction [MTF1 protein binds to MTF1 promoter]; zinc chloride promotes the reaction [MTF1 protein binds to SLC30A2 promoter]; zinc chloride results in decreased phosphorylation of and affects the localization of MTF1 protein
zinc chloride affects the localization of MTF1 protein
zinc chloride results in decreased expression of MTF1 mRNA

PMID:11551972 PMID:16423564 PMID:18947441 PMID:35027733

NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810

G

metal response element binding transcription factor 2

decreases expression

ISO

zinc chloride results in decreased expression of MTF2 mRNA

NCBI chr14:1,784,218...1,828,463
Ensembl chr14:1,783,627...1,828,414

G

neutrophil cytosolic factor 1

multiple interactions
increases response to substance

ISO

NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]
NCF1 results in increased susceptibility to zinc chloride

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

N-myc downstream regulated 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of NDRG1 mRNA]

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913

G

NADH:ubiquinone oxidoreductase complex assembly factor 5

decreases expression

ISO

zinc chloride results in decreased expression of NDUFAF5 mRNA

NCBI chr 3:147,961,612...147,991,128
Ensembl chr 3:147,961,599...147,991,126

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

decreases expression
multiple interactions

ISO

zinc chloride results in decreased expression of NF2 mRNA
NF2 protein affects the reaction [zinc chloride results in increased expression of MT1A mRNA]; NF2 protein affects the reaction [zinc chloride results in increased expression of SLC30A2 mRNA]

PMID:16870260 PMID:35027733

NCBI chr14:83,850,894...83,934,263
Ensembl chr14:83,850,894...83,934,151

G

NFE2 like bZIP transcription factor 2

affects response to substance
multiple interactions

ISO
EXP

[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to zinc chloride
[Sodium Selenite co-treated with zinc chloride] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein]
zinc chloride promotes the reaction [SLC39A2 protein results in increased activity of NFE2L2 protein]

PMID:18385089 PMID:19303893 PMID:36646412

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

increases activity

ISO

zinc chloride results in increased activity of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nucleolar pre-rRNA processing protein NIP7

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of NIP7 mRNA]

NCBI chr19:51,872,306...51,874,448
Ensembl chr19:51,872,364...51,876,120

G

nicotinamide nucleotide adenylyltransferase 1

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of NMNAT1 mRNA

NCBI chr 5:165,193,301...165,211,213
Ensembl chr 5:165,193,302...165,211,231

G

nitric oxide synthase 1

multiple interactions

EXP

zinc chloride inhibits the reaction [Tamoxifen results in increased expression of NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

multiple interactions

ISO

zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NADPH oxidase 4

increases expression

ISO

zinc chloride results in increased expression of NOX4 mRNA

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

netrin 3

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of NTN3 mRNA

NCBI chr10:13,741,459...13,744,555
Ensembl chr10:13,741,459...13,744,555

G

olfactory receptor family 2 subfamily AG member 2

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of OR2AG2 mRNA

NCBI chr 1:170,107,441...170,108,391
Ensembl chr 1:170,107,441...170,108,391

G

olfactory receptor family 4 subfamily C member 12

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in decreased expression of OR4C12 mRNA

NCBI chr 3:96,403,378...96,404,298
Ensembl chr 3:96,403,378...96,404,298

G

orosomucoid 1

increases expression

ISO

zinc chloride results in increased expression of ORM1 mRNA

NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667

G

purinergic receptor P2X 2

multiple interactions

EXP

zinc chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]

NCBI chr12:51,999,107...52,002,627
Ensembl chr12:51,999,372...52,002,627

G

prolyl 4-hydroxylase subunit alpha 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA1 mRNA]

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

prolyl 4-hydroxylase subunit alpha 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of P4HA2 mRNA]

NCBI chr10:38,743,894...38,772,741
Ensembl chr10:38,743,894...38,772,993

G

poly(A) binding protein interacting protein 1

decreases expression

ISO

zinc chloride results in decreased expression of PAIP1 mRNA

NCBI chr 2:53,255,916...53,282,965
Ensembl chr 2:53,237,924...53,282,966

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases response to substance
increases activity
increases expression

ISO

zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]]; zinc chloride inhibits the reaction [sodium arsenite results in decreased activity of PARP1 protein]; zinc chloride promotes the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; Cibacron Blue F 3GA inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; coomassie Brilliant Blue inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of CSF2 protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]; periodate-oxidized adenosine 5'-triphosphate inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]
PARP1 results in increased susceptibility to zinc chloride

PMID:18509044 PMID:19056730 PMID:19714248 PMID:22253048 PMID:33645215

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pterin-4 alpha-carbinolamine dehydratase 1

increases expression

ISO

zinc chloride results in increased expression of PCBD1 mRNA

NCBI chr20:29,573,362...29,587,181
Ensembl chr20:29,573,423...29,587,180

G

proliferating cell nuclear antigen

multiple interactions

EXP

[Cadmium Chloride co-treated with zinc chloride] results in increased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

PDGFA associated protein 1

multiple interactions

ISO

zinc chloride promotes the reaction [Cadmium Chloride results in increased expression of PDAP1 mRNA]

NCBI chr12:14,584,414...14,594,641
Ensembl chr12:14,584,398...14,594,641

G

pyruvate dehydrogenase kinase 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PDK1 mRNA]

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145

G

paternally expressed 3

decreases expression

ISO

zinc chloride results in decreased expression of PEG3 mRNA

NCBI chr 1:76,130,965...76,157,774
Ensembl chr 1:76,130,948...76,157,743

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PFKFB3 mRNA]

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PFKFB4 mRNA]

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

placental growth factor

increases expression

ISO

zinc chloride results in increased expression of PGF mRNA

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747

G

phosphoglycerate kinase 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PGK1 mRNA]

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

phosphoglucomutase 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PGM1 mRNA]

NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:119,710,737...119,770,159

G

phosphate regulating endopeptidase X-linked

increases expression

ISO

zinc chloride results in increased expression of PHEX mRNA

NCBI chr X:41,422,561...41,671,226
Ensembl chr X:41,426,101...41,671,226

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

multiple interactions

ISO

PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein]; PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein]

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509

G

phosphoinositide-3-kinase, regulatory subunit 4

increases expression

ISO

zinc chloride results in increased expression of PIK3R4 mRNA

NCBI chr 8:115,146,660...115,195,326
Ensembl chr 8:115,146,687...115,195,326

G

phosphoinositide-3-kinase, regulatory subunit 5

increases expression

ISO

zinc chloride results in increased expression of PIK3R5 mRNA

NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539

G

peripheral myelin protein 22

increases expression

ISO

zinc chloride results in increased expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940

G

protein kinase C, alpha

multiple interactions
affects localization

EXP

1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]; 1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of PRKCA protein]; Glucose promotes the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]; Vanadates promotes the reaction [zinc chloride affects the localization of PRKCA protein]; zinc chloride affects the localization of and results in increased activity of PRKCA protein

PMID:20800666 PMID:21575692

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

parathyroid hormone 1 receptor

multiple interactions

ISO

[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of PTH1R mRNA

NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:119,575,868...119,598,108

G

RAB20, member RAS oncogene family

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RAB20 mRNA]

NCBI chr16:84,721,427...84,745,610
Ensembl chr16:84,721,427...84,745,610

G

Rac family small GTPase 1

multiple interactions

ISO

RAC1 protein affects the reaction [zinc chloride results in increased activity of MAPK8 protein]

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

RAD21 cohesin complex component

increases expression

ISO

zinc chloride results in increased expression of RAD21 mRNA

NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:85,177,716...85,204,657

G

RAD51 associated protein 1

increases expression

ISO

zinc chloride results in increased expression of RAD51AP1 mRNA

NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases phosphorylation

EXP

1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]; manumycin inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein]

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RAN GTPase activating protein 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RANGAP1 mRNA]

NCBI chr 7:115,104,820...115,130,564
Ensembl chr 7:115,104,823...115,130,564

G

recombination signal binding protein for immunoglobulin kappa J region

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RBPJ mRNA]

NCBI chr14:61,551,366...61,736,220
Ensembl chr14:61,551,366...61,736,307

G

reversion-inducing-cysteine-rich protein with kazal motifs

multiple interactions

ISO

zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]; zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein]

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
multiple interactions

ISO

zinc chloride results in increased phosphorylation of RELA protein
RELA protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein]; RELA protein affects the reaction [zinc chloride results in increased secretion of IL6 protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

replication timing regulatory factor 1

increases expression

ISO

zinc chloride results in increased expression of RIF1 mRNA

NCBI chr 3:56,963,840...57,017,106
Ensembl chr 3:56,963,854...57,017,106

G

RIO kinase 3

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RIOK3 mRNA]

NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,602,535...3,628,108

G

RAR-related orphan receptor A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RORA mRNA]

NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730

G

ribosomal protein L11

decreases expression

ISO

zinc chloride results in decreased expression of RPL11 mRNA

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal RNA processing 15 homolog

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RRP15 mRNA]

NCBI chr13:100,807,729...100,830,812
Ensembl chr13:100,807,722...100,830,834

G

ribosome biogenesis regulator 1 homolog

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RRS1 mRNA]

NCBI chr 5:14,516,303...14,517,936
Ensembl chr 5:14,515,254...14,517,943

G

RUNX family transcription factor 2

multiple interactions

ISO

[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of RUNX2 protein; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 protein

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

RuvB-like AAA ATPase 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RUVBL1 mRNA]

NCBI chr 4:122,489,754...122,524,666
Ensembl chr 4:122,489,680...122,524,665

G

spalt-like transcription factor 1

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of SALL1 mRNA

NCBI chr19:34,179,316...34,196,278
Ensembl chr19:34,181,078...34,196,278

G

Sin3A associated protein 30

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SAP30 mRNA]

NCBI chr16:37,758,494...37,763,825
Ensembl chr16:37,757,656...37,763,823

G

strawberry notch homolog 1

increases expression

ISO

zinc chloride results in increased expression of SBNO1 mRNA

NCBI chr12:37,835,306...37,895,861
Ensembl chr12:37,846,514...37,891,231

G

scavenger receptor class A, member 3

decreases expression

ISO

zinc chloride results in decreased expression of SCARA3 mRNA

NCBI chr15:44,315,422...44,348,416
Ensembl chr15:44,315,422...44,348,551

G

scavenger receptor class B, member 1

increases expression

ISO

zinc chloride results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

stearoyl-CoA desaturase

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SCD mRNA]

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

selectin P ligand

increases expression

ISO

zinc chloride results in increased expression of SELPLG mRNA

NCBI chr12:48,457,102...48,470,444
Ensembl chr12:48,456,932...48,473,154

G

SERTA domain containing 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SERTAD2 mRNA]

NCBI chr14:98,935,428...99,039,536
Ensembl chr14:98,934,769...99,041,468

G

SH3 and multiple ankyrin repeat domains 2

multiple interactions
increases expression

EXP

[COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein; Copper inhibits the reaction [zinc chloride results in increased expression of SHANK2 protein]

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions
increases expression

EXP

[COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein; Copper inhibits the reaction [zinc chloride results in increased expression of SHANK3 protein]

NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:122,448,323...122,510,410

G

solute carrier family 11 member 2

increases transport

ISO

SLC11A2 protein results in increased transport of zinc chloride

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

solute carrier family 16 member 3

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SLC16A3 mRNA]

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 1 member 2

multiple interactions

ISO

[Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 1 member 5

decreases expression

ISO

zinc chloride results in decreased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054

G

solute carrier family 25 member 15

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of SLC25A15 mRNA]

NCBI chr16:76,334,037...76,357,325
Ensembl chr16:76,324,288...76,357,321

G

solute carrier family 2 member 1

multiple interactions
increases expression

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 mRNA]
zinc chloride results in increased expression of SLC2A1 mRNA

PMID:19000923 PMID:22202117 PMID:37797845

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 30 member 1

multiple interactions
increases expression

ISO
EXP

epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of SLC30A1 mRNA]; zinc chloride inhibits the reaction [Grape Seed Proanthocyanidins results in decreased expression of SLC30A1 mRNA]
zinc chloride affects the reaction [Cadmium Chloride affects the expression of SLC30A1 mRNA]; zinc chloride promotes the reaction [Glucose results in increased expression of SLC30A1 mRNA]

PMID:18947441 PMID:20392624 PMID:20471814 PMID:23056475 PMID:25653005 More...

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 30 member 2

increases expression
multiple interactions

EXP
ISO

zinc chloride results in increased expression of SLC30A2 mRNA
MTF1 protein mutant form inhibits the reaction [zinc chloride promotes the reaction [MTF1 protein binds to SLC30A2 promoter]]; NF2 protein affects the reaction [zinc chloride results in increased expression of SLC30A2 mRNA]; zinc chloride promotes the reaction [MTF1 protein binds to SLC30A2 promoter]
zinc chloride affects the reaction [Cadmium Chloride affects the expression of SLC30A2 mRNA]

PMID:20392624 PMID:25653005 PMID:35027733

NCBI chr 5:151,843,451...151,855,674
Ensembl chr 5:151,843,389...151,855,670

G

solute carrier family 30 member 4

multiple interactions

EXP

zinc chloride affects the reaction [Cadmium Chloride affects the expression of SLC30A4 mRNA]

NCBI chr 3:130,206,852...130,228,888
Ensembl chr 3:130,206,852...130,228,888

G

solute carrier family 30 member 5

decreases expression
multiple interactions

ISO

zinc chloride results in decreased expression of SLC30A5 mRNA
Dactinomycin inhibits the reaction [zinc chloride results in decreased expression of SLC30A5 mRNA]

PMID:17234632 PMID:20392624

NCBI chr 2:33,679,800...33,710,025
Ensembl chr 2:33,679,800...33,712,596

G

solute carrier family 30 member 7

increases expression
decreases expression

ISO

zinc chloride results in increased expression of SLC30A7 mRNA
zinc chloride results in decreased expression of SLC30A7 mRNA

NCBI chr 2:206,544,800...206,607,087
Ensembl chr 2:206,544,800...206,607,043

G

solute carrier family 31 member 2

increases expression
decreases expression

ISO

zinc chloride results in increased expression of SLC31A2 mRNA
zinc chloride results in decreased expression of SLC31A2 mRNA

NCBI chr 5:80,753,589...80,764,126
Ensembl chr 5:80,753,618...80,764,123

G

solute carrier family 39 member 1

multiple interactions

ISO

zinc chloride inhibits the reaction [Grape Seed Proanthocyanidins results in increased expression of SLC39A1 mRNA]

NCBI chr 2:178,001,052...178,006,689
Ensembl chr 2:178,001,119...178,006,689

G

solute carrier family 39 member 10

multiple interactions

ISO

[sodium arsenite co-treated with zinc chloride] affects the expression of and affects the localization of SLC39A10 mRNA

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:62,370,598...62,454,747

G

solute carrier family 39 member 14

multiple interactions

ISO

[sodium arsenite co-treated with zinc chloride] affects the expression of and affects the localization of SLC39A14 mRNA

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229

G

solute carrier family 39 member 2

multiple interactions
increases expression

ISO

[SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione; zinc chloride promotes the reaction [SLC39A2 protein results in increased activity of NFE2L2 protein]; zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLC mRNA]; zinc chloride promotes the reaction [SLC39A2 protein results in increased expression of GCLM mRNA]
zinc chloride results in increased expression of SLC39A2 mRNA

NCBI chr15:27,063,699...27,066,349
Ensembl chr15:27,064,237...27,066,349

G

solute carrier family 39 member 3

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A3 mRNA]

NCBI chr 7:9,327,541...9,333,542
Ensembl chr 7:9,327,455...9,335,845

G

solute carrier family 39 member 4

multiple interactions
decreases expression

ISO
EXP

zinc chloride inhibits the reaction [Grape Seed Proanthocyanidins results in increased expression of SLC39A4 mRNA]
zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A4 mRNA]
zinc chloride results in decreased expression of SLC39A4 mRNA

PMID:20471814 PMID:25653005

NCBI chr 7:110,214,017...110,218,202
Ensembl chr 7:110,214,017...110,218,202

G

solute carrier family 39 member 8

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A8 mRNA]

NCBI chr 2:226,845,686...226,992,668
Ensembl chr 2:226,929,644...226,992,667

G

solute carrier family 48 member 1

increases expression

ISO

zinc chloride results in increased expression of SLC48A1 mRNA

NCBI chr 7:130,794,233...130,802,119
Ensembl chr 7:130,794,245...130,803,022

G

solute carrier family 5 member 1

multiple interactions

ISO

zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]]; zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of SLC5A1 mRNA]

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 5 member 2

multiple interactions

ISO

zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP110 protein binds to and affects the expression of SLC5A2 promoter]]; zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of SLC5A2 mRNA]

NCBI chr 1:192,277,621...192,283,742
Ensembl chr 1:192,277,621...192,283,742

G

solute carrier family 9 member A1

increases expression

ISO

zinc chloride results in increased expression of SLC9A1 mRNA

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

superoxide dismutase 1

multiple interactions

EXP

zinc chloride inhibits the reaction [Tamoxifen results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sorbitol dehydrogenase

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in decreased activity of SORD protein]

NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100

G

Sp1 transcription factor

multiple interactions
increases activity

ISO

zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]]
zinc chloride results in increased activity of SP1 protein

PMID:9330853 PMID:20060848

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

SP110 nuclear body protein

multiple interactions

ISO

zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP110 protein binds to and affects the expression of SLC5A2 promoter]]

NCBI chr 9:93,648,574...93,673,476
Ensembl chr 9:93,648,575...93,670,659

G

sperm associated antigen 4

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SPAG4 mRNA]

NCBI chr 3:165,040,682...165,047,963
Ensembl chr 3:165,041,134...165,045,519

G

spindle and centriole associated protein 1

decreases expression

ISO

zinc chloride results in decreased expression of SPICE1 mRNA

NCBI chr11:69,796,490...69,838,304
Ensembl chr11:69,795,884...69,838,266

G

serine peptidase inhibitor, Kazal type 1

decreases expression

ISO

zinc chloride results in decreased expression of SPINK1 mRNA

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

sparc/osteonectin, cwcv and kazal like domains proteoglycan 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SPOCK1 mRNA]

NCBI chr17:6,746,892...7,227,034
Ensembl chr17:6,747,646...7,230,282

G

secreted phosphoprotein 1

decreases expression
multiple interactions

ISO

zinc chloride results in decreased expression of SPP1 mRNA
[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SPP1 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SPP1 mRNA; zinc chloride promotes the reaction [Calcitriol results in increased activity of SPP1 promoter]

PMID:10777672 PMID:19428942 PMID:19913120

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
increases phosphorylation

EXP

1,3-dimethylthiourea inhibits the reaction [zinc chloride results in increased phosphorylation of SRC protein]; AG 1879 inhibits the reaction [zinc chloride results in increased phosphorylation of SRC protein]; Vanadates promotes the reaction [zinc chloride results in increased phosphorylation of SRC protein]

PMID:12211081 PMID:21575692

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

spermidine synthase

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of SRM mRNA]

NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:164,308,991...164,332,705

G

starch binding domain 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of STBD1 mRNA]

NCBI chr14:15,754,769...15,758,174
Ensembl chr14:15,754,644...15,761,659

G

stathmin 1

increases expression

ISO

zinc chloride results in increased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

telomerase reverse transcriptase

multiple interactions

ISO

[Citric Acid co-treated with zinc chloride] results in decreased activity of TERT protein

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

transferrin

multiple interactions
increases expression

ISO

zinc chloride inhibits the reaction [TF protein results in increased uptake of Iron]
zinc chloride results in increased expression of TF mRNA

PMID:11335103 PMID:18947441

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

tissue factor pathway inhibitor 2

increases expression

ISO

zinc chloride results in increased expression of TFPI2 mRNA

NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426

G

transferrin receptor

increases expression

ISO

zinc chloride results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transmembrane protein 45A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of TMEM45A mRNA]

NCBI chr11:57,181,686...57,268,630
Ensembl chr11:57,182,785...57,282,722

G

tumor necrosis factor

increases expression
multiple interactions

ISO
EXP

zinc chloride results in increased expression of TNF mRNA
[Sodium Selenite co-treated with zinc chloride] affects the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of TNF protein]; zinc chloride inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of TNF protein]; zinc chloride inhibits the reaction [Tamoxifen results in increased expression of TNF protein]

PMID:19428942 PMID:21540303 PMID:24284788 PMID:31532279 PMID:36646412

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in decreased expression of TNFRSF11B protein]

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF superfamily member 11

multiple interactions

EXP

zinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of TNFSF11 protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TNF superfamily member 14

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of TNFSF14 mRNA

NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,155,270...2,160,191

G

tumor protein p53

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

transformer 2 alpha

decreases expression

ISO

zinc chloride results in decreased expression of TRA2A mRNA

NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:79,551,542...79,570,619

G

TSC22 domain family, member 3

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

transthyretin

multiple interactions

ISO

[zinc chloride results in increased abundance of Zinc] which results in increased expression of TTR mRNA

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

tubulin, alpha 1B

increases expression

ISO

zinc chloride results in increased expression of TUBA1B mRNA

NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:131,968,770...131,996,035

G

ubiquitin-like modifier activating enzyme 1

multiple interactions

ISO

zinc chloride promotes the reaction [Dimethyldithiocarbamate results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; zinc chloride results in decreased activity of and results in decreased ubiquitination of UBA1 protein

NCBI chr X:4,062,216...4,084,192
Ensembl chr X:4,062,182...4,084,246

G

ubiquitin-conjugating enzyme E2E 2

increases expression

ISO

zinc chloride results in increased expression of UBE2E2 mRNA

NCBI chr15:9,411,067...9,688,731
Ensembl chr15:9,411,539...9,712,661

G

unc-5 netrin receptor B

increases expression

ISO

zinc chloride results in increased expression of UNC5B mRNA

NCBI chr20:29,240,639...29,307,270
Ensembl chr20:29,240,650...29,307,270

G

unconventional SNARE in the ER 1

increases expression

ISO

zinc chloride results in increased expression of USE1 mRNA

NCBI chr16:18,069,118...18,075,816
Ensembl chr16:18,070,793...18,075,814

G

utrophin

affects binding

ISO

zinc chloride binds to UTRN protein

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

G

vascular endothelial growth factor A

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]
zinc chloride inhibits the reaction [Doxorubicin results in increased expression of VEGFA mRNA]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WD repeat domain 4

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of WDR4 mRNA]

NCBI chr20:9,588,532...9,604,718
Ensembl chr20:9,588,532...9,605,007

G

WD repeat and SOCS box-containing 1

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of WSB1 mRNA]

NCBI chr10:64,700,752...64,717,038
Ensembl chr10:64,700,762...64,716,832

G

X-C motif chemokine receptor 1

decreases expression

ISO

zinc chloride results in decreased expression of XCR1 mRNA

NCBI chr 8:132,357,020...132,393,596
Ensembl chr 8:132,357,020...132,385,862

G

Yes1 associated transcriptional regulator

multiple interactions

ISO

zinc chloride results in decreased phosphorylation of and affects the localization of YAP1 protein

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437

G

YEATS domain containing 2

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of YEATS2 mRNA]

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292

G

zinc finger protein 292

multiple interactions

ISO

zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ZNF292 mRNA]

NCBI chr 5:54,184,174...54,264,454
Ensembl chr 5:54,184,174...54,304,147

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxymethylbilane synthase

decreases activity

EXP

Zinc ion decreases activity of purified Hmbs protein

RGD

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

zinc molecular entity

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

EXP

Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Zinc Compounds results in increased expression of BAX mRNA; Zinc Compounds results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Zinc Compounds results in decreased expression of BCL2 mRNA; Zinc Compounds results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases expression

ISO

Zinc Compounds results in increased expression of CASP3 mRNA; Zinc Compounds results in increased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

EXP

Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 21

increases expression

ISO

Zinc Compounds results in increased expression of CCL21 mRNA

NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:61,776,413...61,777,540

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

ISO

Zinc Compounds results in decreased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

early growth response 1

decreases expression

ISO

Zinc Compounds results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

glutamic--pyruvic transaminase

multiple interactions

EXP

Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

heme oxygenase 1

decreases expression

ISO

Zinc Compounds results in decreased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 1A

decreases expression
multiple interactions

ISO
EXP

Zinc Compounds results in decreased expression of HSPA1A mRNA
Zinc Compounds analog inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]; Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]

PMID:16945336 PMID:24035972

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

decreases expression

ISO

Zinc Compounds results in decreased expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

interleukin 1 beta

increases expression

ISO

Zinc Compounds results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

insulin 1

multiple interactions

EXP

Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

leptin

multiple interactions

EXP

Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

metallothionein 2

increases expression

ISO

Zinc Compounds results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

nuclear factor kappa B subunit 1

increases expression

ISO

Zinc Compounds results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 2

increases expression

ISO

Zinc Compounds results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

serpin family E member 1

decreases expression

ISO

Zinc Compounds results in decreased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

tumor necrosis factor

multiple interactions

EXP

Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

decreases expression

ISO

Zinc Compounds results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

tumor protein p53

increases expression

ISO

Zinc Compounds results in increased expression of TP53 mRNA; Zinc Compounds results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 1 member A5

decreases expression

ISO

Zinc Compounds results in decreased expression of UGT1A4 mRNA

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

ISO

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-X-C motif chemokine ligand 3

increases expression
multiple interactions

ISO

zinc nitrate results in increased expression of CXCL1 mRNA
MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CXCL1 mRNA]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

glucose-6-phosphate dehydrogenase

decreases activity

EXP

zinc nitrate results in decreased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

interleukin 6

multiple interactions
increases expression

ISO

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CCL2 mRNA]; MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CXCL1 mRNA]; MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of TNF mRNA]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

tumor necrosis factor

multiple interactions
increases expression

ISO

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases expression

ISO

Zinc Oxide results in increased expression of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adrenoceptor beta 1

decreases expression

ISO

Zinc Oxide analog results in decreased expression of ADRB1 mRNA

NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237

G

adrenoceptor beta 3

decreases expression

ISO

Zinc Oxide analog results in decreased expression of ADRB3 mRNA

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

angiotensin II receptor, type 1a

decreases expression

ISO

Zinc Oxide analog results in decreased expression of AGTR1 mRNA

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of AKT1 protein

PMID:24374571 PMID:24614525 PMID:28115650

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

increases secretion
multiple interactions
affects binding
increases response to substance

ISO
EXP

Zinc Oxide results in increased secretion of ALB protein
ALB protein promotes the reaction [Zinc Oxide binds to Dimethoate]
Zinc Oxide binds to ALB protein
ALB protein results in increased susceptibility to Zinc Oxide
[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in decreased expression of ALB protein

PMID:23726862 PMID:27441385 PMID:28212817

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

apoptotic peptidase activating factor 1

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of APAF1 mRNA

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

androgen receptor

increases expression

ISO

Zinc Oxide results in increased expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

autophagy related 10

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA]

NCBI chr 2:23,843,695...24,133,459
Ensembl chr 2:23,844,482...24,133,368

G

autophagy related 12

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of ATG12 mRNA
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261

G

autophagy related 5

increases expression
multiple interactions

ISO
EXP

Zinc Oxide analog results in increased expression of ATG5 mRNA
Zinc Oxide results in increased expression of ATG5 mRNA
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]

PMID:24614525 PMID:32951350

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

autophagy related 7

increases expression

EXP

Zinc Oxide results in increased expression of ATG7 mRNA

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

ISO

Zinc Oxide analog results in decreased expression of ATP2A2 mRNA

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATPase plasma membrane Ca2+ transporting 1

decreases expression

ISO

Zinc Oxide analog results in decreased expression of ATP2B1 mRNA; Zinc Oxide analog results in decreased expression of ATP2B1 protein

NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:35,622,461...35,731,904

G

BCL2 associated X, apoptosis regulator

increases expression
affects expression
multiple interactions

ISO
EXP

Zinc Oxide analog results in increased expression of BAX mRNA; Zinc Oxide analog results in increased expression of BAX protein; Zinc Oxide results in increased expression of BAX mRNA
Zinc Oxide affects the expression of BAX mRNA
lead acetate promotes the reaction [Zinc Oxide results in increased expression of BAX mRNA]; Zinc Oxide inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of BAX mRNA]
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]

PMID:24614525 PMID:25680694 PMID:27544635 PMID:33236829 PMID:33599401 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

decreases activity

ISO

Zinc Oxide results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

ISO
EXP

Zinc Oxide analog results in decreased expression of BCL2 mRNA; Zinc Oxide analog results in decreased expression of BCL2 protein; Zinc Oxide results in decreased expression of BCL2 mRNA
Zinc Oxide results in increased expression of BCL2 mRNA
lead acetate promotes the reaction [Zinc Oxide results in decreased expression of BCL2 mRNA]; Zinc Oxide inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]

PMID:24614525 PMID:25680694 PMID:27544635 PMID:33236829 PMID:33599401 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein]
Zinc Oxide results in increased expression of BECN1 mRNA; Zinc Oxide results in increased expression of BECN1 protein

PMID:24614525 PMID:32951350

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

BH3 interacting domain death agonist

multiple interactions

ISO

Zinc Oxide affects the splicing of and affects the expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2 interacting protein 3

increases expression

ISO

Zinc Oxide results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

caspase 1

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased cleavage of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

increases expression
increases activity

EXP
ISO

Zinc Oxide results in increased expression of CASP12 mRNA
Zinc Oxide analog results in increased activity of CASP12 protein

PMID:23232460 PMID:25680694

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases activity
increases expression
multiple interactions
increases cleavage

ISO

Zinc Oxide analog results in increased activity of CASP3 protein; Zinc Oxide results in increased activity of CASP3 protein
Zinc Oxide results in increased expression of CASP3 mRNA
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Zinc Oxide analog results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; Zinc Oxide affects the splicing of and results in increased expression of CASP3 mRNA

PMID:22112499 PMID:24614525 PMID:25680694 PMID:27544635 PMID:30500950 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions
increases activity
increases cleavage

ISO

Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]
Zinc Oxide analog results in increased activity of CASP8 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]

PMID:24614525 PMID:27544635

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage
increases activity
multiple interactions

ISO

Zinc Oxide analog results in increased cleavage of CASP9 protein
Zinc Oxide analog results in increased activity of CASP9 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP9 protein]

PMID:24614525 PMID:25680694 PMID:27544635

Ensembl chr 5:159,391,188...159,409,648

G

catalase

decreases expression
multiple interactions
decreases activity

ISO
EXP

Zinc Oxide results in decreased expression of CAT mRNA; Zinc Oxide results in decreased expression of CAT protein
Zinc Oxide promotes the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Quercetin inhibits the reaction [Zinc Oxide analog results in decreased activity of CAT protein]
Zinc Oxide analog results in decreased activity of CAT protein; Zinc Oxide results in decreased activity of CAT protein

PMID:19382294 PMID:24614525 PMID:27111109 PMID:31804693 PMID:32600046 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

increases expression
decreases expression
increases secretion
multiple interactions

ISO
EXP

Zinc Oxide analog results in increased expression of CCL2 mRNA; Zinc Oxide analog results in increased expression of CCL2 protein
Zinc Oxide results in decreased expression of CCL2 protein
Zinc Oxide analog results in increased secretion of CCL2 protein
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:20851137 PMID:23352990 PMID:24746987 PMID:31804693 PMID:33205376 More...

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

decreases expression

EXP

Zinc Oxide results in decreased expression of CCL20 protein

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 22

decreases expression

EXP

Zinc Oxide results in decreased expression of CCL22 protein

NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359

G

C-C motif chemokine ligand 5

affects expression

EXP

Zinc Oxide affects the expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

CD36 molecule

multiple interactions

ISO

[Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein

NCBI chr 4:18,209,088...18,302,142

G

Cd63 molecule

increases expression

ISO

Zinc Oxide results in increased expression of CD63 protein

NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,922,169...1,924,938

G

cell division cycle 42

multiple interactions

ISO

[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Zinc Oxide analog results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclic GMP-AMP synthase

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of CGAS protein
RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of CGAS protein]

NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:88,174,512...88,185,859

G

cholinergic receptor, muscarinic 3

multiple interactions

ISO

Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

collagen type III alpha 1 chain

increases expression

ISO

Zinc Oxide analog results in increased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

cAMP responsive element binding protein 5

decreases expression

ISO

Zinc Oxide analog results in decreased expression of CREB5 mRNA

NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:83,723,194...84,120,793

G

crystallin, mu

decreases expression

ISO

Zinc Oxide analog results in decreased expression of CRYM mRNA

NCBI chr 1:183,991,752...184,006,923
Ensembl chr 1:183,991,745...184,006,962

G

colony stimulating factor 2

multiple interactions

ISO

Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

affects expression

EXP

Zinc Oxide affects the expression of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

cystatin C

decreases expression

EXP

Zinc Oxide results in decreased expression of CST3 protein

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

C-X-C motif chemokine ligand 2

decreases expression
increases expression

EXP
ISO

Zinc Oxide results in decreased expression of CXCL2 protein
Zinc Oxide analog results in increased expression of CXCL2 mRNA

PMID:33205376 PMID:36100149

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of CXCL1 mRNA
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]

PMID:23352990 PMID:36100149

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine ligand 9

increases expression

ISO

Zinc Oxide results in increased expression of CXCL9

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

cytochrome c, somatic

increases expression

ISO

Zinc Oxide results in increased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

ISO
EXP

Zinc Oxide results in decreased expression of CYP11A1 mRNA
Zinc Oxide inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]

PMID:33236829 PMID:37682394

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

ISO

Zinc Oxide results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

deleted in azoospermia-like

increases expression

ISO

Zinc Oxide results in increased expression of DAZL mRNA

NCBI chr 9:18,193,363...18,210,100
Ensembl chr 9:18,193,363...18,210,100

G

DNA-damage inducible transcript 3

increases expression

ISO

Zinc Oxide analog results in increased expression of DDIT3 mRNA; Zinc Oxide analog results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DEAD-box helicase 4

increases expression

ISO

Zinc Oxide results in increased expression of DDX4 mRNA

NCBI chr 2:45,961,174...46,016,097
Ensembl chr 2:45,961,174...46,015,951

G

7-dehydrocholesterol reductase

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

DnaJ heat shock protein family (Hsp40) member A4

increases expression

ISO

Zinc Oxide results in increased expression of DNAJA4 protein

NCBI chr 8:63,975,177...63,998,836
Ensembl chr 8:63,981,559...63,998,836

G

developmental pluripotency-associated 3

increases expression

ISO

Zinc Oxide results in increased expression of DPPA3 mRNA

NCBI chr 4:157,523,426...157,526,810
Ensembl chr 5:93,143,318...93,144,472
Ensembl chr 4:93,143,318...93,144,472

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

ISO

Zinc Oxide analog results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

ISO

Zinc Oxide analog results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

estrogen receptor 1

decreases expression

ISO

Zinc Oxide results in decreased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

Fas cell surface death receptor

multiple interactions
decreases expression
increases expression

ISO

benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein]
Zinc Oxide results in decreased expression of FAS mRNA
Zinc Oxide affects the splicing of and results in increased expression of FAS mRNA

PMID:27544635 PMID:30500950 PMID:32600046

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Zinc Oxide results in increased expression of FOS protein

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

growth arrest and DNA-damage-inducible, beta

increases expression

ISO

Zinc Oxide results in increased expression of GADD45B protein

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression
increases expression

ISO

1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole promotes the reaction [Zinc Oxide analog results in increased expression of GCLC protein]; [Zinc Oxide analog co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of GCLC mRNA; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of GCLC mRNA]; Zinc Oxide affects the splicing of and results in increased expression of GCLC mRNA

PMID:30500950 PMID:35247504 PMID:36100149

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

ISO

[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide analog results in increased expression of GCLM protein]; [Zinc Oxide analog co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of GCLM protein; RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of GCLM protein]; Zinc Oxide affects the splicing of and results in increased expression of GCLM mRNA
Zinc Oxide analog results in increased expression of GCLM mRNA; Zinc Oxide analog results in increased expression of GCLM protein

PMID:30500950 PMID:35247504 PMID:36368621 PMID:36535435

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

growth differentiation factor 15

decreases expression

EXP

Zinc Oxide results in decreased expression of GDF15 protein

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

gamma-glutamyltransferase 1

multiple interactions

EXP

[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein; [lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

GLI family zinc finger 1

increases expression

ISO

Zinc Oxide results in increased expression of GLI1 mRNA

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540

G

GLI family zinc finger 2

increases expression

ISO

Zinc Oxide results in increased expression of GLI2 mRNA

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418

G

GLI family zinc finger 3

increases expression

ISO

Zinc Oxide results in increased expression of GLI3 mRNA

NCBI chr17:54,134,064...54,405,198
Ensembl chr17:54,134,064...54,405,198

G

glutamic--pyruvic transaminase

increases expression
multiple interactions

ISO
EXP

Zinc Oxide analog results in increased expression of GPT protein
Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased uptake of GPT protein]

PMID:25680694 PMID:29024620

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

decreases activity
decreases expression
multiple interactions

ISO

Zinc Oxide analog results in decreased activity of GSR protein
Zinc Oxide analog results in decreased expression of GSR mRNA
NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of GSR mRNA]; Zinc Oxide affects the splicing of and affects the expression of GSR mRNA

PMID:24614525 PMID:30500950 PMID:36100149

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione synthetase

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of GSS mRNA

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306

G

H2A.X variant histone

increases activity
multiple interactions

ISO

Zinc Oxide analog results in increased activity of H2AX protein
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

heme oxygenase 1

increases expression
multiple interactions

EXP
ISO

Zinc Oxide results in increased expression of HMOX1 mRNA; Zinc Oxide results in increased expression of HMOX1 protein
RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of HMOX1 protein]
Zinc Oxide analog results in increased expression of HMOX1 mRNA; Zinc Oxide analog results in increased expression of HMOX1 protein; Zinc Oxide results in increased expression of HMOX1 mRNA
[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide analog results in increased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in increased expression of HMOX1 mRNA]; RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of HMOX1 protein]; Zinc Oxide affects the splicing of and results in increased expression of HMOX1 mRNA
Zinc Oxide analog results in increased expression of HMOX1 protein; Zinc Oxide results in increased expression of HMOX1 protein

PMID:21769377 PMID:22640810 PMID:29289694 PMID:30500950 PMID:33599401 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid (17-beta) dehydrogenase 1

increases expression

ISO

Zinc Oxide results in increased expression of HSD17B1 mRNA

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

EXP

Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD17B3 mRNA]

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases expression
multiple interactions

EXP

Zinc Oxide analog results in decreased expression of HSD3B6 mRNA
Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of HSD3B6 mRNA]

NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569

G

heat shock transcription factor 1

increases activity

ISO

Zinc Oxide results in increased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein 90 beta family member 1

increases expression

ISO

Zinc Oxide analog results in increased expression of HSP90B1 mRNA

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO

Zinc Oxide results in increased expression of HSPA1A protein

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Zinc Oxide analog results in increased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

5-hydroxytryptamine receptor 4

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of HTR4 mRNA
[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide results in increased expression of HTR4 mRNA]

NCBI chr18:58,036,277...58,221,327
Ensembl chr18:58,036,277...58,219,622

G

intercellular adhesion molecule 1

multiple interactions
affects expression
increases expression

ISO
EXP

[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; BAY 11-7085 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of ICAM1 protein]
Zinc Oxide affects the expression of ICAM1 protein
Zinc Oxide analog results in increased expression of ICAM1 protein; Zinc Oxide results in increased expression of ICAM1 mRNA; Zinc Oxide results in increased expression of ICAM1 protein

PMID:22166487 PMID:24746987 PMID:25127755 PMID:33205376

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

increases expression
multiple interactions

ISO

Zinc Oxide results in increased expression of IFNG protein
Zinc Oxide affects the splicing of and results in increased expression of IFNG mRNA

PMID:24368203 PMID:30500950

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1

affects expression

EXP

Zinc Oxide affects the expression of IGF1 protein

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein 2

affects expression

EXP

Zinc Oxide affects the expression of IGFBP2 protein

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

interleukin 10

increases expression

ISO

Zinc Oxide analog results in increased expression of IL10 protein; Zinc Oxide results in increased expression of IL10 protein

PMID:20851137 PMID:24368203

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12B

multiple interactions

EXP

Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of IL12B protein]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 1 alpha

affects expression

EXP

Zinc Oxide affects the expression of IL1A protein

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression
decreases expression
multiple interactions

ISO
EXP

Zinc Oxide analog results in increased expression of IL1B mRNA; Zinc Oxide results in increased expression of IL1B
Zinc Oxide results in decreased expression of IL1B protein
RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of IL1B mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of IL1B mRNA]; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:19897006 PMID:24631018 PMID:25127755 PMID:31804693 PMID:33205376 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor antagonist

decreases expression

EXP

Zinc Oxide results in decreased expression of IL1RN protein

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 3

affects expression

EXP

Zinc Oxide affects the expression of IL3 protein

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810

G

interleukin 4

multiple interactions
decreases expression

EXP

lead acetate promotes the reaction [Zinc Oxide results in decreased expression of IL4 protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

increases secretion
affects expression
increases expression
multiple interactions

EXP
ISO

Zinc Oxide results in increased secretion of IL6 protein
Zinc Oxide affects the expression of IL6 protein
Zinc Oxide analog results in increased expression of IL6 protein
Zinc Oxide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Zinc Oxide analog results in increased expression of IL6 mRNA; Zinc Oxide results in increased expression of IL6 protein
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; Zinc Oxide affects the splicing of and results in increased expression of IL6 mRNA; Zinc Oxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:17301066 PMID:23352990 PMID:24368203 PMID:24631018 PMID:27185063 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin-1 receptor-associated kinase 1

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of IRAK1 protein]

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
affects localization

ISO

JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein
Zinc Oxide results in increased expression of JUN protein

PMID:22166487 PMID:24368203

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysosomal-associated membrane protein 2

increases expression

ISO

Zinc Oxide results in increased expression of LAMP2 protein

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:121,922,187...122,087,675

G

galectin 1

decreases expression

EXP

Zinc Oxide results in decreased expression of LGALS1 protein

NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800

G

galectin 3

decreases expression

EXP

Zinc Oxide results in decreased expression of LGALS3 protein

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of LYN protein]

NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:21,437,084...21,554,461

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
affects lipidation
increases expression

ISO
EXP

MAP1LC3B mutant form inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]
Zinc Oxide affects the lipidation of MAP1LC3B protein
Zinc Oxide results in increased expression of MAP1LC3B mRNA; Zinc Oxide results in increased expression of MAP1LC3B protein

PMID:24614525 PMID:29289694 PMID:32951350 PMID:34766255

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen-activated protein kinase kinase kinase 11

multiple interactions
increases expression

ISO

NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein]

NCBI chr 1:212,404,685...212,417,986
Ensembl chr 1:212,403,680...212,417,983

G

mitogen activated protein kinase 1

multiple interactions

ISO

homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK1 protein

PMID:24374571 PMID:28115650

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein]
[Zinc Oxide results in increased abundance of Zinc] which results in increased phosphorylation of MAPK3 protein

PMID:24374571 PMID:28115650

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 9

increases expression

ISO

Zinc Oxide results in increased expression of MAPK9 mRNA

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

O-6-methylguanine-DNA methyltransferase

increases expression

ISO

Zinc Oxide results in increased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

matrix metallopeptidase 13

decreases expression

ISO

Zinc Oxide analog results in decreased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

increases expression

ISO

Zinc Oxide analog results in increased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 3

decreases expression

EXP

Zinc Oxide results in decreased expression of MMP3 protein

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

increases secretion
multiple interactions
decreases expression
increases activity

ISO
EXP

Zinc Oxide results in increased secretion of MMP9 protein
Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MMP9 protein]
Zinc Oxide results in decreased expression of MMP9 protein
Zinc Oxide results in increased activity of MMP9 protein

PMID:23726862 PMID:25127755 PMID:33205376

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

increases secretion

ISO

Zinc Oxide results in increased secretion of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

macrophage scavenger receptor 1

multiple interactions

ISO

[Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MSR1 protein

NCBI chr16:59,421,250...59,507,070
Ensembl chr16:59,421,057...59,507,070

G

mechanistic target of rapamycin kinase

decreases phosphorylation
decreases expression

ISO
EXP

Zinc Oxide analog results in decreased phosphorylation of MTOR protein
Zinc Oxide results in decreased expression of MTOR protein modified form

PMID:24614525 PMID:32951350

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MYD88 protein]

PMID:23352990 PMID:25127755

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions
increases expression

ISO
EXP

Zinc Oxide analog results in decreased expression of NFE2L2 protein
NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of GCLC mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of GSR mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of SOD1 mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of TGFB1 mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in increased expression of HMOX1 mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]
Zinc Oxide analog results in increased expression of NFE2L2 protein
lead acetate promotes the reaction [Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein]; Zinc Oxide inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 mRNA]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of and affects the localization of NFE2L2 protein]; Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein

PMID:24614525 PMID:34553816 PMID:35247504 PMID:36100149 PMID:37682394

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in decreased expression of NFKB2 mRNA

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

multiple interactions

ISO

Zinc Oxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NOBOX oogenesis homeobox

decreases expression

ISO

Zinc Oxide results in decreased expression of NOBOX mRNA

NCBI chr 4:73,128,926...73,134,431
Ensembl chr 4:73,127,925...73,134,630

G

nitric oxide synthase 2

increases expression

ISO

Zinc Oxide results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

[Zinc Oxide analog co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of NQO1 mRNA; [Zinc Oxide analog co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of NQO1 protein; Zinc Oxide affects the splicing of and results in increased expression of NQO1 mRNA
Zinc Oxide analog results in increased expression of NQO1 protein

PMID:30500950 PMID:35247504

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

ISO

Zinc Oxide analog results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 5, group A, member 1

multiple interactions
decreases expression

EXP

Quercetin inhibits the reaction [Zinc Oxide analog results in decreased expression of NR5A1 mRNA]

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

protein disulfide isomerase family A, member 3

increases expression

ISO

Zinc Oxide analog results in increased expression of PDIA3 mRNA

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

progesterone receptor

decreases expression

ISO

Zinc Oxide results in decreased expression of PGR mRNA

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

PR/SET domain 1

increases expression

ISO

Zinc Oxide results in increased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088

G

peroxiredoxin 3

increases expression

ISO

Zinc Oxide results in increased expression of PRDX3 mRNA

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

prolactin

decreases expression

EXP

Zinc Oxide results in decreased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prion protein

increases expression

ISO

Zinc Oxide results in increased expression of PRNP mRNA

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436

G

patched 1

increases expression

ISO

Zinc Oxide results in increased expression of PTCH1 mRNA

NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,548,449...1,613,461

G

prostaglandin-endoperoxide synthase 1

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

ISO

Zinc Oxide results in increased expression of PTGS2 protein
Zinc Oxide affects the splicing of and affects the expression of PTGS2 mRNA; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of PTGS2 protein]

PMID:24368203 PMID:25127755 PMID:30500950

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

Rac family small GTPase 1

multiple interactions

ISO

[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]; NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]; Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

RAD51 recombinase

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

retinol binding protein 4

affects expression

EXP

Zinc Oxide affects the expression of RBP4 protein

NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
multiple interactions

ISO

Zinc Oxide results in increased phosphorylation of RELA protein
[Zinc Oxide results in increased phosphorylation of RELA protein] promotes the reaction [RELA protein binds to CXCL8 promoter]; Zinc Oxide promotes the reaction [RELA protein binds to CXCL8 promoter]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

receptor interacting serine/threonine kinase 1

increases expression

ISO

Zinc Oxide results in increased expression of RIPK1 mRNA

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 2

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of RIPK2 mRNA

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

serpin family E member 1

decreases expression

EXP

Zinc Oxide results in decreased expression of SERPINE1 protein

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

solute carrier family 11 member 2

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in decreased expression of SLC11A2 mRNA

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

solute carrier family 12 member 1

decreases expression

ISO

Zinc Oxide analog results in decreased expression of SLC12A1 mRNA

NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:132,859,590...132,936,340

G

solute carrier family 30 member 1

increases expression

ISO

Zinc Oxide results in increased expression of SLC30A1 mRNA

PMID:29289694 PMID:33599401

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

smoothened, frizzled class receptor

increases expression

ISO

Zinc Oxide results in increased expression of SMO mRNA

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

superoxide dismutase 1

increases expression
multiple interactions
decreases expression

ISO

Zinc Oxide results in increased expression of SOD1 mRNA
NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of SOD1 mRNA]

PMID:32600046 PMID:36100149

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases expression

ISO

Zinc Oxide results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

secreted phosphoprotein 1

decreases expression

EXP

Zinc Oxide results in decreased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sequestosome 1

increases expression
multiple interactions
decreases expression

ISO

Zinc Oxide results in increased expression of SQSTM1 protein
[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide analog results in increased expression of SQSTM1 protein]
Zinc Oxide results in decreased expression of SQSTM1 protein

PMID:29289694 PMID:34766255 PMID:36535435

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sulfiredoxin 1

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

somatostatin

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of SST mRNA
[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide results in increased expression of SST mRNA]

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823

G

somatostatin receptor 2

multiple interactions
increases expression

ISO

[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide results in increased expression of SSTR2 mRNA]
Zinc Oxide analog results in increased expression of SSTR2 mRNA

NCBI chr10:99,163,353...99,170,519
Ensembl chr10:99,162,740...99,183,863

G

steroidogenic acute regulatory protein

decreases expression

ISO

Zinc Oxide results in decreased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 1

decreases expression

ISO

Zinc Oxide analog results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

stimulator of interferon response cGAMP interactor 1

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of STING1 protein
RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of STING1 protein]

NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,606,196...27,611,947

G

stimulated by retinoic acid 8

decreases expression

ISO

Zinc Oxide results in decreased expression of STRA8 mRNA

NCBI chr 4:64,568,580...64,591,914
Ensembl chr 4:64,568,706...64,591,911

G

spleen associated tyrosine kinase

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of SYK protein]

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278

G

telomerase reverse transcriptase

increases expression

ISO

Zinc Oxide results in increased expression of TERT mRNA

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

transforming growth factor, beta 1

increases expression
decreases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of TGFB1 mRNA
Zinc Oxide analog results in decreased expression of TGFB1 mRNA
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole inhibits the reaction [Zinc Oxide analog results in increased expression of TGFB1 mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in decreased expression of TGFB1 mRNA]

PMID:35247504 PMID:36100149

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

toll-like receptor 1

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR1 mRNA]

NCBI chr14:43,737,761...43,750,389
Ensembl chr14:43,740,379...43,756,243

G

toll-like receptor 2

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 protein]

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 4

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR4 mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

toll-like receptor 6

multiple interactions

ISO

Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR6 mRNA]; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR6 protein]

NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,698,751...43,740,462

G

tumor necrosis factor

increases expression
decreases expression
multiple interactions

ISO
EXP

Zinc Oxide analog results in increased expression of TNF mRNA; Zinc Oxide results in increased expression of TNF protein
Zinc Oxide results in decreased expression of TNF protein
lead acetate promotes the reaction [Zinc Oxide results in increased expression of TNF protein]; Zinc Oxide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of TNF protein]
MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]; NFE2L2 protein inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]; RU.521 inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]

PMID:23352990 PMID:24368203 PMID:29024620 PMID:33205376 PMID:34553816 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

Zinc Oxide results in increased phosphorylation of and results in increased expression of TP53 protein
Zinc Oxide analog results in increased expression of TRP53 protein

PMID:21903158 PMID:24614525

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TNF receptor associated factor 6

multiple interactions

ISO

Zinc Oxide affects the splicing of and results in increased expression of TRAF6 mRNA; Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TRAF6 protein]

PMID:25127755 PMID:30500950

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

thyroid stimulating hormone subunit beta

multiple interactions
decreases secretion

EXP

lead acetate promotes the reaction [Zinc Oxide results in decreased secretion of TSHB protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased secretion of TSHB protein]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

thioredoxin 1

increases expression
multiple interactions

ISO

Zinc Oxide analog results in increased expression of TXN1 protein
[Vancomycin co-treated with Neomycin co-treated with Metronidazole] promotes the reaction [Zinc Oxide analog results in increased expression of TXN1 protein]

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin reductase 1

increases expression
multiple interactions

ISO

Zinc Oxide results in increased expression of TXNRD1 mRNA
Zinc Oxide affects the splicing of and affects the expression of TXNRD1 mRNA

PMID:19755143 PMID:30500950

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

voltage-dependent anion channel 1

increases expression

ISO

Zinc Oxide results in increased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

X-box binding protein 1

increases expression

ISO

Zinc Oxide analog results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

zinc finger protein 36

increases expression

ISO

Zinc Oxide results in increased expression of ZFP36 protein

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

zinc protoporphyrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]

PMID:20052772 PMID:20861358

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

angiotensinogen

multiple interactions

ISO

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

AKT serine/threonine kinase 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aminolevulinate dehydratase

affects abundance

ISO

ALAD gene SNP affects the abundance of zinc protoporphyrin

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

albumin

multiple interactions

ISO

ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]
zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]

PMID:19376148 PMID:21163135

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

ALMS1, centrosome and basal body associated protein

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA

NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:119,683,076...119,783,471

G

adaptor related protein complex 2 subunit alpha 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA

NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:104,520,792...104,550,655

G

adaptor related protein complex 3 subunit delta 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA

NCBI chr 7:9,620,909...9,656,350
Ensembl chr 7:9,620,968...9,656,342

G

anti-silencing function 1A histone chaperone

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA

NCBI chr20:33,436,632...33,451,478
Ensembl chr20:33,436,707...33,449,639

G

BTB domain and CNC homolog 1

multiple interactions

EXP

zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in increased expression of PTGS2 mRNA]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in increased expression of PTGS2 protein]]

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]

PMID:22763982 PMID:27523796 PMID:32621855

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
increases expression

EXP
ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein]
zinc protoporphyrin results in increased expression of BCL2L1 protein

PMID:20357190 PMID:27829220

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

ISO

zinc protoporphyrin results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

bone gamma-carboxyglutamate protein

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [15-deoxyprostaglandin J2 results in decreased expression of BGLAP mRNA]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased expression of BGLAP mRNA]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

baculoviral IAP repeat-containing 3

multiple interactions

ISO

zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein]

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

calcitonin-related polypeptide alpha

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

cullin-associated and neddylation-dissociated 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA

NCBI chr 7:56,566,765...56,604,653
Ensembl chr 7:56,551,394...56,604,655

G

caspase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

multiple interactions
increases cleavage
decreases activity

ISO
EXP

zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
zinc protoporphyrin results in increased cleavage of CASP3 protein
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein]
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]
zinc protoporphyrin results in decreased activity of CASP3 protein

PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP9 protein]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein]

PMID:27375190 PMID:29432840 PMID:30261164

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP
ISO

zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]]

PMID:32621855 PMID:35691465

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

coiled-coil domain containing 6

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA

NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,431,243...18,527,227

G

C-C motif chemokine ligand 2

multiple interactions

EXP
ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CCL2 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of CCL2 mRNA]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]]

PMID:20357190 PMID:23892052 PMID:35691465

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine receptor 7

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCR7 mRNA]

NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501

G

CD40 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

Cd80 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

CD83 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD83 mRNA]

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

CD86 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

cyclin-dependent kinase 13

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CDK13 mRNA

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

chromodomain helicase DNA binding protein 7

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA

NCBI chr 5:26,609,245...26,792,736
Ensembl chr 5:26,609,407...26,792,734

G

carboxymethylenebutenolidase homolog

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

C-X-C motif chemokine ligand 1

increases expression

EXP

zinc protoporphyrin results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 2

increases expression

EXP

zinc protoporphyrin results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2B1 protein

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP
ISO

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]

PMID:19325051 PMID:26747958

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

defective in cullin neddylation 1 domain containing 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA

NCBI chr 2:120,649,445...120,700,879
Ensembl chr 2:120,649,445...120,700,870

G

DNA-damage inducible transcript 3

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DExH-box helicase 29

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA

NCBI chr 2:46,293,901...46,344,652
Ensembl chr 2:46,293,677...46,344,948

G

dual specificity phosphatase 10

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

EMAP like 4

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of EML4 mRNA

NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439

G

coagulation factor II, thrombin

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]]

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

Fas ligand

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box and WD repeat domain containing 12

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FBXW12 mRNA

NCBI chr 8:118,660,777...118,680,565
Ensembl chr 8:118,660,605...118,680,572

G

Fibroblast growth factor receptor 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

Fms related receptor tyrosine kinase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

zinc protoporphyrin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

fucosyltransferase 4

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of FUT4 mRNA

NCBI chr 8:19,868,178...19,872,139
Ensembl chr 8:19,868,079...19,872,436

G

glutamate-ammonia ligase

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]; zinc protoporphyrin inhibits the reaction [Resveratrol results in increased activity of GLUL protein]

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

G protein-coupled receptor 132

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of GPR132 mRNA

NCBI chr 6:137,745,142...137,763,037
Ensembl chr 6:137,745,241...137,763,157

G

glutathione peroxidase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 4

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX4 protein]
zinc protoporphyrin inhibits the reaction [Cadmium results in decreased expression of GPX4 protein]

PMID:36696656 PMID:39025289

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

gasdermin D

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

HAUS augmin like complex subunit 2

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of HAUS2 mRNA

NCBI chr 3:128,006,894...128,019,730
Ensembl chr 3:128,006,932...128,019,729

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

homeostatic iron regulator

affects abundance

ISO

HFE gene polymorphism affects the abundance of zinc protoporphyrin

NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,841,252...41,851,208

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

high mobility group box 1

multiple interactions

EXP
ISO

zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]

PMID:29447957 PMID:30261164

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression
affects expression
decreases activity

ISO
EXP

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to Arsenic Trioxide; [zinc protoporphyrin results in decreased activity of HMOX1] which results in decreased susceptibility to peoniflorin; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]; zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; zinc protoporphyrin results in decreased expression of and results in decreased activity of HMOX1 protein; zinc protoporphyrin results in increased expression of and results in decreased activity of HMOX1 protein
zinc protoporphyrin results in decreased expression of HMOX1 mRNA; zinc protoporphyrin results in decreased expression of HMOX1 protein
zinc protoporphyrin results in increased expression of HMOX1 protein
zinc protoporphyrin affects the expression of HMOX1 mRNA; zinc protoporphyrin affects the expression of HMOX1 protein
zinc protoporphyrin results in decreased activity of HMOX1; zinc protoporphyrin results in decreased activity of HMOX1 protein
zinc protoporphyrin results in increased expression of HMOX1 mRNA; zinc protoporphyrin results in increased expression of HMOX1 protein
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Resveratrol results in increased abundance of Glutathione]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in decreased susceptibility to Resveratrol; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [perflexane promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of HMOX1 protein]
[zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of HMOX1 protein]]

PMID:7524564 PMID:12352873 PMID:14649057 PMID:15602829 PMID:16462769 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heme oxygenase 2

decreases activity
decreases expression

ISO
EXP

zinc protoporphyrin results in decreased activity of HMOX2 protein
zinc protoporphyrin results in decreased expression of HMOX2 protein

PMID:21448202 PMID:25824035

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

heterochromatin protein 1, binding protein 3

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of HP1BP3 mRNA

NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:155,719,115...155,746,325

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]]

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

intercellular adhesion molecule 1

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of ICAM1 mRNA]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]

PMID:19608869 PMID:23892052 PMID:33049506

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon beta 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487

G

interferon gamma

multiple interactions
increases expression

EXP

zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]
zinc protoporphyrin results in increased expression of IFNG mRNA

PMID:21295052 PMID:25780291

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 protein]; zinc protoporphyrin inhibits the reaction [perflexane inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of IL10 protein]]

PMID:20056245 PMID:20360627

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12B

multiple interactions

ISO

zinc protoporphyrin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 18

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein]

PMID:18215737 PMID:36858639

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
zinc protoporphyrin results in increased expression of IL1B mRNA
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of IL1B mRNA]

PMID:20131233 PMID:21295052 PMID:23892052 PMID:25780291 PMID:27523796 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 23 subunit alpha

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]]

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 6

multiple interactions
increases expression

ISO
EXP

zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]
zinc protoporphyrin results in increased expression of IL6 mRNA
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]

PMID:19608869 PMID:20131233 PMID:21963524 PMID:25780291 PMID:27523796 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol polyphosphate-5-phosphatase D

decreases expression

EXP

zinc protoporphyrin results in decreased expression of INPP5D protein

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589

G

interleukin-1 receptor-associated kinase 1

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interleukin-1 receptor-associated kinase 3

decreases expression

EXP

zinc protoporphyrin results in decreased expression of IRAK3 protein