tributylstannane - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tributylstannane	go back to main search page
Accession:	CHEBI:27086	browse the term
Definition:	An organotin compound that has formula C12H28Sn.
Synonyms:	related_synonym:	Formula=C12H28Sn; InChI=1S/3C4H9.Sn.H/c31-3-4-2;;/h31,3-4H2,2H3;;; InChIKey=DBGVGMSCBYYSLD-UHFFFAOYSA-N; SMILES=[H][Sn](CCCC)(CCCC)CCCC; SnBu3H; TBT; Tri-n-butyltin; Tri-n-butyltin hydride; Tributyltin; [Sn(Bu)3H]
	xref:	Beilstein:3587329; CAS:688-73-3; Gmelin:4258
	xref_mesh:	MESH:C011559
	xref:	UM-BBD_compID:c0579

show annotations for term's descendants Sort by:
Rat (1078) Mouse (1059) Human (1051) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (1078)

tributylstannane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

decreases expression

tributyltin results in decreased expression of A1BG mRNA

NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097

G

AADACL2 family member 2

increases expression

tributyltin results in increased expression of AADACL2FM2 mRNA

NCBI chr 2:143,883,313...143,910,452
Ensembl chr 2:143,883,265...143,911,452

G

aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of AASDHPPT mRNA

NCBI chr 8:1,453,226...1,463,990
Ensembl chr 8:1,452,282...1,463,966

G

ATP binding cassette subfamily A member 1

increases expression
multiple interactions

tributyltin results in increased expression of ABCA1; tributyltin results in increased expression of ABCA1 mRNA
diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]
[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA; [tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein; diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]; UVI 3003 inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]

PMID:21622945 PMID:23824090 PMID:24356939 PMID:25932594 PMID:31006824

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

decreases expression
increases expression

tributyltin results in decreased expression of ABCB1 protein
tributyltin results in increased expression of ABCB1A mRNA

PMID:26079211 PMID:31939706

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 1

increases expression

tributyltin results in increased expression of ABCG1 mRNA

PMID:23824090 PMID:24356939

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

acetyl-CoA acyltransferase 2

increases expression

tributyltin results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acetyl-CoA carboxylase alpha

increases expression

tributyltin results in increased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase, long chain

increases expression

tributyltin results in increased expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

acyl-CoA dehydrogenase medium chain

increases expression

tributyltin results in increased expression of ACADM mRNA

PMID:23428407 PMID:24848799

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase, very long chain

increases expression

tributyltin results in increased expression of ACADVL mRNA

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ACAP2 mRNA

NCBI chr11:69,538,487...69,654,156
Ensembl chr11:69,538,546...69,654,151

G

acetyl-CoA acetyltransferase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ACAT1 mRNA

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

acetyl-CoA acetyltransferase 2-like 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ACAT2L1 mRNA

NCBI chr 1:47,803,822...47,829,012
Ensembl chr 1:47,803,813...47,829,151

G

angiotensin I converting enzyme

increases expression

tributyltin results in increased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

increases expression

tributyltin results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

aconitase 2

increases expression

tributyltin results in increased expression of ACO2 mRNA

PMID:23428407 PMID:24848799

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 3

increases expression

tributyltin results in increased expression of ACOT3 mRNA

NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA oxidase 1

increases expression

tributyltin results in increased expression of ACOX1 mRNA

PMID:23322813 PMID:23428407

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA oxidase-like

increases expression

tributyltin results in increased expression of ACOXL mRNA

NCBI chr 3:115,061,069...115,367,032
Ensembl chr 3:115,061,060...115,364,686

G

acyl-CoA synthetase long-chain family member 1

increases expression

tributyltin results in increased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 3

increases expression

tributyltin results in increased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

acyl-CoA synthetase short-chain family member 1

increases expression

tributyltin results in increased expression of ACSS1 mRNA

NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325

G

actin alpha 2, smooth muscle

increases expression

tributyltin results in increased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actinin, alpha 1

increases expression

tributyltin results in increased expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

adenosine deaminase

increases expression

tributyltin results in increased expression of ADA mRNA

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase domain 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

ADAM metallopeptidase with thrombospondin type 1 motif, 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ADAMTS2 mRNA

NCBI chr10:34,920,992...35,126,465
Ensembl chr10:34,921,049...35,123,821

G

ArfGAP with dual PH domains 1

increases expression

tributyltin results in increased expression of ADAP1 mRNA

NCBI chr12:15,323,913...15,376,110
Ensembl chr12:15,324,209...15,380,831

G

adenosine deaminase, RNA-specific, B1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ADARB1 mRNA

NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852

G

adenylate cyclase 1

decreases expression

tributyltin results in decreased expression of ADCY1 mRNA

NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969

G

adenylate cyclase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ADCY2 mRNA; [bisphenol A co-treated with tributyltin] results in increased expression of ADCY2 protein

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

ADCYAP receptor type I

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ADCYAP1R1 mRNA

NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700

G

adiponectin, C1Q and collagen domain containing

multiple interactions
decreases expression
decreases secretion
affects expression
increases expression

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] affects the expression of ADIPOQ protein; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]
tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]; tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
tributyltin results in decreased expression of ADIPOQ protein
tributyltin results in decreased secretion of ADIPOQ protein
tributyltin affects the expression of ADIPOQ protein
tributyltin results in increased expression of ADIPOQ mRNA; tributyltin results in increased expression of ADIPOQ protein

PMID:22197818 PMID:23428407 PMID:28161095 PMID:28397090 PMID:29675927 More...

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 2

increases expression

tributyltin results in increased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adrenoceptor beta 2

decreases expression

tributyltin results in decreased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

alpha-fetoprotein

increases expression

tributyltin results in increased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

1-acylglycerol-3-phosphate O-acyltransferase 2

increases expression

tributyltin results in increased expression of AGPAT2 mRNA

NCBI chr 3:9,416,837...9,428,567
Ensembl chr 3:9,416,843...9,428,371

G

1-acylglycerol-3-phosphate O-acyltransferase 3

increases expression

tributyltin results in increased expression of AGPAT3 mRNA

NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358

G

angiotensinogen

increases expression
decreases expression

tributyltin results in increased expression of AGT mRNA
tributyltin results in decreased expression of AGT protein modified form

PMID:23428407 PMID:30172001

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

increases expression

tributyltin results in increased expression of AGTR1A protein

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

decreases expression

tributyltin results in decreased expression of AGTR2 protein

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

AHNAK nucleoprotein

increases expression

tributyltin results in increased expression of AHNAK mRNA

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

aryl hydrocarbon receptor

decreases expression

tributyltin results in decreased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions
decreases expression

tributyltin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]
tributyltin results in decreased expression of AHRR mRNA

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

allograft inflammatory factor 1

multiple interactions
decreases expression

Phycocyanin inhibits the reaction [tributyltin results in decreased expression of AIF1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AIF family member 2

increases expression

tributyltin results in increased expression of AIFM2 mRNA

NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236

G

aldo-keto reductase family 1 member B1

increases expression

tributyltin results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1, member B7

increases expression

tributyltin results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

AKT serine/threonine kinase 1

increases expression
increases phosphorylation

tributyltin results in increased expression of AKT1 protein
tributyltin results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

5'-aminolevulinate synthase 1

increases expression

tributyltin results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

aldehyde dehydrogenase 18 family, member A1

increases expression

tributyltin results in increased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ALDH1A1 mRNA; [bisphenol A co-treated with tributyltin] results in decreased expression of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 8 family, member A1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

ALG8, alpha-1,3-glucosyltransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ALG8 mRNA

NCBI chr 1:151,684,344...151,704,310
Ensembl chr 1:151,684,396...151,704,302

G

arachidonate 5-lipoxygenase activating protein

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of ALOX5AP mRNA
tributyltin results in decreased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

alkaline phosphatase, biomineralization associated

multiple interactions
decreases expression

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]
tributyltin results in decreased expression of ALPL mRNA; tributyltin results in decreased expression of ALPL protein

PMID:22749964 PMID:23322813 PMID:25777084

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

angiogenin

decreases expression

tributyltin results in decreased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

angiopoietin 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin-like 4

increases expression

tributyltin results in increased expression of ANGPTL4 mRNA

PMID:21622945 PMID:21683754 PMID:23428407

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin repeat domain 27

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ANKRD27 mRNA

NCBI chr 1:88,251,216...88,303,615
Ensembl chr 1:88,251,226...88,303,615

G

ankyrin repeat domain 37

increases expression

tributyltin results in increased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

annexin A4

increases expression

tributyltin results in increased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A5

multiple interactions
decreases expression

Tretinoin promotes the reaction [tributyltin results in decreased expression of ANXA5 protein]

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

adaptor related protein complex 1 subunit mu 2

increases expression

tributyltin results in increased expression of AP1M2 mRNA

NCBI chr 8:19,838,579...19,856,560
Ensembl chr 8:19,838,580...19,856,482

G

adaptor related protein complex 3 subunit sigma 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of AP3S2 mRNA

NCBI chr 1:133,818,825...133,859,269
Ensembl chr 1:133,818,825...133,859,322

G

apolipoprotein C1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of APOC1 mRNA

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

apolipoprotein E

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein L2

decreases expression
multiple interactions

tributyltin results in decreased expression of APOL2 mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of APOL2 mRNA

NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558

G

androgen receptor

multiple interactions

tributyltin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

Rho GTPase activating protein 36

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ARHGAP36 mRNA

NCBI chr X:128,780,148...128,787,169
Ensembl chr X:128,751,900...128,787,161

G

Rho guanine nucleotide exchange factor 16

increases expression

tributyltin results in increased expression of ARHGEF16 mRNA

NCBI chr 5:164,843,656...164,866,212
Ensembl chr 5:164,844,161...164,866,212

G

ADP-ribosyltransferase 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ART3 mRNA

NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407

G

ankyrin repeat and SOCS box-containing 10

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ASB10 mRNA

NCBI chr 4:10,630,318...10,644,270
Ensembl chr 4:10,630,448...10,639,060

G

achaete-scute family bHLH transcription factor 1

multiple interactions

[tributyltin co-treated with LHB protein] results in increased expression of ASCL1 mRNA

NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993

G

achaete-scute family bHLH transcription factor 2

affects expression

tributyltin affects the expression of ASCL2 mRNA

NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406

G

asialoglycoprotein receptor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

tributyltin results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

aspartoacylase

increases expression

tributyltin results in increased expression of ASPA mRNA

NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272

G

asporin

increases expression

tributyltin results in increased expression of ASPN mRNA

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041

G

astacin like metalloendopeptidase

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ASTL mRNA

NCBI chr 3:114,563,135...114,580,295
Ensembl chr 3:114,563,135...114,578,868

G

ATPase family, AAA domain containing 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ATAD5 mRNA

NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845

G

activating transcription factor 2

increases phosphorylation

tributyltin results in increased phosphorylation of ATF2 protein

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 3

increases expression

tributyltin results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

increases cleavage

tributyltin results in increased cleavage of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATM serine/threonine kinase

increases phosphorylation
multiple interactions

tributyltin results in increased phosphorylation of ATM protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of ATM protein]

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase phospholipid transporting 11A

decreases expression

tributyltin results in decreased expression of ATP11A mRNA

NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

tributyltin results in decreased expression of ATP2A2 protein

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of B3GALNT1 mRNA

NCBI chr 2:153,847,297...153,877,371
Ensembl chr 2:153,846,474...153,877,332

G

Beta-1,3-galactosyltransferase 1

decreases expression

tributyltin results in decreased expression of B3GALT1 mRNA

NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

increases expression

tributyltin results in increased expression of B3GNT3 mRNA

NCBI chr16:18,401,405...18,410,821
Ensembl chr16:18,401,405...18,410,766

G

BCL2-associated agonist of cell death

multiple interactions

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BAD protein modified form]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 3

affects expression

tributyltin affects the expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BAR/IMD domain containing adaptor protein 2 like 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BAIAP2L1 mRNA

NCBI chr12:10,250,434...10,339,937
Ensembl chr12:10,250,473...10,339,928

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

tributyltin affects the expression of BAX protein
PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of BAX protein]
Phycocyanin inhibits the reaction [tributyltin results in increased expression of BAX protein]

PMID:22223438 PMID:23743147 PMID:25895139 PMID:26079211 PMID:28707438

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 2A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BAZ2A mRNA

NCBI chr 7:523,204...560,911
Ensembl chr 7:523,265...560,659

G

BBSome interacting protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BBIP1 mRNA

NCBI chr 1:252,943,589...252,959,512
Ensembl chr 1:252,945,557...252,959,352

G

Bardet-Biedl syndrome 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BBS2 mRNA

NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993

G

branched chain amino acid transaminase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

affects expression
decreases expression
multiple interactions

tributyltin affects the expression of BCL2 protein
tributyltin results in decreased expression of BCL2 protein
PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]

PMID:22223438 PMID:23743147 PMID:25743928 PMID:25895139 PMID:26079211 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bradykinin receptor B1

decreases expression

tributyltin results in decreased expression of BDKRB1 mRNA

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

beclin 1

decreases expression

tributyltin results in decreased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
tributyltin results in increased expression of BGLAP mRNA

PMID:22749964 PMID:25932594

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

biglycan

increases expression

tributyltin results in increased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e41

increases expression

tributyltin results in increased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

BicC family RNA binding protein 1

decreases expression

tributyltin results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

baculoviral IAP repeat-containing 2

decreases expression

tributyltin results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

decreases expression

tributyltin results in decreased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

basic helix-loop-helix ARNT like 1

decreases expression

tributyltin results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

Bcl2 modifying factor

increases expression

tributyltin results in increased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

bone morphogenetic protein receptor type 1B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BMPR1B mRNA

NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368

G

BCL2 interacting protein 5

increases expression

tributyltin results in increased expression of BNIP5 mRNA

NCBI chr20:6,957,736...6,975,062
Ensembl chr20:6,956,201...6,975,091

G

biorientation of chromosomes in cell division 1-like 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BOD1L1 mRNA

NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490

G

bromodomain containing 9

increases expression

tributyltin results in increased expression of BRD9 mRNA

NCBI chr 1:29,329,981...29,357,285
Ensembl chr 1:29,329,985...29,357,016

G

bassoon (presynaptic cytomatrix protein)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BSN mRNA

NCBI chr 8:108,784,849...108,875,819
Ensembl chr 8:108,788,542...108,875,819

G

B-box and SPRY domain containing

increases expression

tributyltin results in increased expression of BSPRY mRNA

NCBI chr 5:75,927,397...75,949,585
Ensembl chr 5:75,927,405...75,949,583

G

BTG anti-proliferation factor 2

decreases expression

tributyltin results in decreased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 17 open reading frame 58

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of C10H17ORF58 mRNA

NCBI chr10:91,972,938...91,977,606
Ensembl chr10:91,972,410...91,977,602

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

tributyltin results in decreased expression of C1GALT1 mRNA

NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831

G

complement C1r subcomponent like

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of C1RL mRNA

NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134

G

complement C5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of C5 mRNA

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

complement C8 gamma chain

multiple interactions
affects binding

tributyltin inhibits the reaction [triphenyltin binds to C8G protein]
tributyltin binds to C8G protein

NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495

G

calcium voltage-gated channel subunit alpha1 H

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium dependent secretion activator 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CADPS2 mRNA

NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829

G

calmodulin 1

multiple interactions

CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]; tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin-like 4

increases expression

tributyltin results in increased expression of CALML4 mRNA

NCBI chr 8:63,323,426...63,335,234
Ensembl chr 8:63,323,351...63,335,234

G

calreticulin 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CALR3 mRNA

NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015

G

calcium/calmodulin-dependent protein kinase II beta

increases activity
decreases expression
multiple interactions

tributyltin results in increased activity of CAMK2B protein
tributyltin results in decreased expression of CAMK2B mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of CAMK2B mRNA

PMID:20810541 PMID:31129395

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II delta

increases activity

tributyltin results in increased activity of CAMK2D protein

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase II gamma

increases activity

tributyltin results in increased activity of CAMK2G protein

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

G

calmodulin binding transcription activator 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CAMTA1 mRNA

NCBI chr 5:161,510,283...162,356,902
Ensembl chr 5:161,510,283...162,356,723

G

calpain 12

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CAPN12 mRNA

NCBI chr 1:84,171,059...84,183,161
Ensembl chr 1:84,171,059...84,183,119

G

carbonic anhydrase 13

increases expression

tributyltin results in increased expression of CAR13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

carbonic anhydrase 14

increases expression

tributyltin results in increased expression of CAR14 mRNA

NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693

G

carbonic anhydrase 9

increases expression

tributyltin results in increased expression of CAR9 mRNA

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

caspase 12

increases expression

tributyltin results in increased expression of CASP12 protein

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage
decreases expression
increases activity
increases expression

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased activity of CASP3 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; SB 203580 inhibits the reaction [tributyltin results in increased expression of CASP3 protein]; tributyltin results in increased expression of and results in increased cleavage of CASP3 protein
tributyltin results in increased cleavage of CASP3 protein
DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP3 protein]
PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]
tributyltin results in increased expression of CASP3 protein; tributyltin results in increased expression of CASP3 protein modified form

PMID:17341481 PMID:21477642 PMID:21626652 PMID:21683754 PMID:22223438 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

multiple interactions
decreases expression

DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP6 protein]

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases activity

tributyltin results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases expression
decreases expression

tributyltin results in increased expression of CASP8 protein
tributyltin results in decreased expression of CASP8 protein

PMID:23743147 PMID:28707438

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

multiple interactions

CAST protein inhibits the reaction [tributyltin results in increased degradation of MAPT protein]; CAST protein inhibits the reaction [tributyltin results in increased degradation of NEFM protein]; CAST protein inhibits the reaction [tributyltin results in increased degradation of TUBB3 protein]

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

castor zinc finger 1

increases expression

tributyltin results in increased expression of CASZ1 mRNA

NCBI chr 5:159,243,965...159,393,935
Ensembl chr 5:159,243,995...159,393,400

G

catalase

multiple interactions
decreases activity
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of CAT mRNA; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CAT protein]
tributyltin results in decreased activity of CAT protein

PMID:26079211 PMID:26873547 PMID:31129395 PMID:33720505 PMID:34902535

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cerebellin 1 precursor

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CBLN1 mRNA

NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572

G

coiled-coil domain containing 125

decreases expression

tributyltin results in decreased expression of CCDC125 mRNA

NCBI chr 2:31,809,120...31,835,538
Ensembl chr 2:31,809,228...31,850,152

G

coiled-coil domain containing 159

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CCDC159 mRNA

NCBI chr 8:20,457,905...20,467,232
Ensembl chr 8:20,457,909...20,466,562

G

C-C motif chemokine ligand 2

increases expression

tributyltin results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 25

increases expression

tributyltin results in increased expression of CCL25 mRNA

NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554

G

C-C motif chemokine ligand 5

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

decreases expression

tributyltin results in decreased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin B1

multiple interactions
decreases expression

dimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CCNB1 protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

C-C motif chemokine receptor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 7

increases expression

tributyltin results in increased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

chaperonin containing TCP1 subunit 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CCT7 mRNA

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

CD22 molecule

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CD22 mRNA

NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322

G

Cd300 molecule-like family member F

increases expression

tributyltin results in increased expression of CD300LF mRNA

NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041

G

CD36 molecule

increases expression

tributyltin results in increased expression of CD36 mRNA

PMID:23428407 PMID:24848799

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

Cd68 molecule

increases expression

tributyltin results in increased expression of CD68 protein

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

CD83 molecule

increases expression

tributyltin results in increased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

cell division cycle 14A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CDC14A mRNA

NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927

G

cell division cycle 25C

decreases expression
multiple interactions

tributyltin results in decreased expression of CDC25C protein
dimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CDC25C protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle associated 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cadherin 9

decreases expression

tributyltin results in decreased expression of CDH9 mRNA

NCBI chr 2:66,280,422...66,367,121
Ensembl chr 2:66,228,117...66,367,121

G

cadherin-related family member 2

increases expression

tributyltin results in increased expression of CDHR2 mRNA

NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575

G

cell death-inducing p53 target 1

increases expression

tributyltin results in increased expression of CDIP1 mRNA

NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980

G

cyclin-dependent kinase 13

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CDK13 mRNA

NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

tributyltin results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions
decreases expression

tributyltin results in increased expression of CDKN1A mRNA; tributyltin results in increased expression of CDKN1A protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]
tributyltin results in decreased expression of CDKN1A mRNA

PMID:28011154 PMID:31939706 PMID:36319700

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of CDKN2B protein]

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cerebellar degeneration-related protein 2

increases expression

tributyltin results in increased expression of CDR2 mRNA

NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472

G

chromodomain Y-like

increases expression

tributyltin results in increased expression of CDYL mRNA

NCBI chr17:28,982,009...29,204,345
Ensembl chr17:28,982,037...29,204,313

G

CCAAT/enhancer binding protein alpha

increases expression
multiple interactions

tributyltin results in increased expression of CEBPA mRNA
T 0070907 inhibits the reaction [tributyltin results in increased expression of CEBPA mRNA]

PMID:25932594 PMID:28011154 PMID:29787037

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

increases expression

tributyltin results in increased expression of CEBPB mRNA

PMID:21683754 PMID:29908848

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CUGBP, Elav-like family member 2

decreases expression

tributyltin results in decreased expression of CELF2 mRNA

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

centrosomal protein 19

increases expression

tributyltin results in increased expression of CEP19 mRNA

NCBI chr11:68,677,869...68,687,117
Ensembl chr11:68,677,871...68,687,022

G

centrosomal protein 76

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CEP76 mRNA

NCBI chr18:61,174,514...61,208,512
Ensembl chr18:61,178,310...61,208,504

G

carboxylesterase 1D

increases expression

tributyltin results in increased expression of CES1D mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cilia and flagella associated protein 210

decreases expression

tributyltin results in decreased expression of CFAP210 mRNA

NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607

G

cilia and flagella associated protein 53

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CFAP53 mRNA

NCBI chr18:67,884,651...67,955,873
Ensembl chr18:67,869,855...67,952,318

G

complement factor D

increases expression

tributyltin results in increased expression of CFD mRNA

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

CF transmembrane conductance regulator

increases expression

tributyltin results in increased expression of CFTR mRNA

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

tributyltin results in decreased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

choline O-acetyltransferase

decreases activity

tributyltin results in decreased activity of CHAT protein

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

chromodomain helicase DNA binding protein 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CHD9 mRNA

NCBI chr19:15,941,535...16,146,220
Ensembl chr19:15,942,687...16,164,556

G

chitinase 3 like 1

increases expression

tributyltin results in increased expression of CHI3L1 mRNA

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

choline kinase alpha

decreases expression

tributyltin results in decreased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

charged multivesicular body protein 4C

increases expression

tributyltin results in increased expression of CHMP4C mRNA

NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668

G

calcineurin-like EF hand protein 2

increases expression

tributyltin results in increased expression of CHP2 mRNA

NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139

G

circadian associated repressor of transcription

increases expression

tributyltin results in increased expression of CIART mRNA

NCBI chr 2:183,419,819...183,424,845
Ensembl chr 2:183,419,819...183,423,313

G

CBY1 interacting BAR domain containing 1

increases expression
multiple interactions

tributyltin results in increased expression of CIBAR1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of CIBAR1 mRNA

NCBI chr 5:25,613,993...25,632,440
Ensembl chr 5:25,614,033...25,632,489

G

cell death-inducing DFFA-like effector a

increases expression

tributyltin results in increased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cell death-inducing DFFA-like effector c

increases expression
multiple interactions

tributyltin results in increased expression of CIDEC mRNA
T 0070907 inhibits the reaction [tributyltin results in increased expression of CIDEC mRNA]

PMID:23322813 PMID:29787037

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

creatine kinase B

increases expression

tributyltin results in increased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

claudin 14

decreases expression

tributyltin results in decreased expression of CLDN14 mRNA

NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171

G

claudin 15

increases expression

tributyltin results in increased expression of CLDN15 mRNA

NCBI chr12:19,698,167...19,708,419
Ensembl chr12:19,698,337...19,706,819

G

claudin 16

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CLDN16 mRNA

NCBI chr11:74,290,298...74,309,588
Ensembl chr11:74,290,298...74,309,588

G

claudin 4

increases expression

tributyltin results in increased expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 5

multiple interactions
decreases expression

Phycocyanin inhibits the reaction [tributyltin results in decreased expression of CLDN5 protein]

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

claudin 7

increases expression

tributyltin results in increased expression of CLDN7 mRNA

NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171

G

chloride intracellular channel 4

increases expression

tributyltin results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

chloride intracellular channel 5

increases expression

tributyltin results in increased expression of CLIC5 mRNA

NCBI chr 9:16,710,980...16,813,502
Ensembl chr 9:16,710,980...16,813,427

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

decreases expression

tributyltin results in decreased expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

calsyntenin 3

increases expression

tributyltin results in increased expression of CLSTN3 mRNA

NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769

G

cytidine monophosphate N-acetylneuraminic acid synthetase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CMAS mRNA

NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125

G

2',3'-cyclic nucleotide 3' phosphodiesterase

increases expression

tributyltin results in increased expression of CNP mRNA

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

collagen type I alpha 1 chain

increases expression

tributyltin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

increases expression

tributyltin results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type II alpha 1 chain

decreases expression

tributyltin results in decreased expression of COL2A1 mRNA

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

collagen type VI alpha 1 chain

increases expression

tributyltin results in increased expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 3 chain

increases expression

tributyltin results in increased expression of COL6A3 mRNA

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

collagen type VII alpha 1 chain

multiple interactions
decreases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of COL7A1 mRNA]

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

collagen type IX alpha 3 chain

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of COL9A3 mRNA

NCBI chr 3:167,711,776...167,734,468
Ensembl chr 3:167,711,840...167,734,465

G

COMM domain containing 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of COMMD9 mRNA

NCBI chr 3:88,175,909...88,190,427
Ensembl chr 3:88,175,987...88,190,439

G

coronin 2A

increases expression

tributyltin results in increased expression of CORO2A mRNA

NCBI chr 5:60,825,630...60,881,917
Ensembl chr 5:60,828,247...60,859,035

G

cytochrome c oxidase subunit 7A1

increases expression

tributyltin results in increased expression of COX7A1 mRNA

PMID:24848799 PMID:31939706

NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151

G

cytochrome c oxidase subunit 7A2 like

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of COX7A2L mRNA

NCBI chr 6:11,184,064...11,198,287
Ensembl chr 6:11,184,285...11,198,273

G

complexin 3

increases expression

tributyltin results in increased expression of CPLX3 mRNA

NCBI chr 8:58,003,535...58,010,297
Ensembl chr 8:58,003,535...58,010,297

G

copine 4

decreases expression

tributyltin results in decreased expression of CPNE4 mRNA

NCBI chr 8:105,177,376...105,653,075
Ensembl chr 8:105,177,376...105,653,068

G

carnitine palmitoyltransferase 1A

increases expression

tributyltin results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

increases expression

tributyltin results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cellular retinoic acid binding protein 1

decreases expression

tributyltin results in decreased expression of CRABP1 mRNA

NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360

G

cellular retinoic acid binding protein 2

increases expression

tributyltin results in increased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

cysteine-rich with EGF-like domains 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CRELD1 mRNA

NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499

G

cAMP responsive element modulator

increases expression

tributyltin results in increased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cysteine rich protein 1

increases expression

tributyltin results in increased expression of CRIP1 mRNA

NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620

G

cytokine receptor-like factor 1

increases expression

tributyltin results in increased expression of CRLF1 mRNA

NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997

G

cartilage acidic protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CRTAC1 mRNA

NCBI chr 1:241,091,679...241,233,677
Ensembl chr 1:241,078,864...241,233,421

G

colony stimulating factor 3

multiple interactions
increases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of CSF3 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cleavage stimulation factor subunit 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CSTF1 mRNA

NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300

G

catenin alpha 1

increases expression

tributyltin results in increased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

increases expression

tributyltin results in increased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin K

multiple interactions
decreases expression

Tetrachlorodibenzodioxin inhibits the reaction [tributyltin results in decreased expression of CTSK mRNA]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X3-C motif chemokine ligand 1

increases expression

tributyltin results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 13

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 14

increases expression

tributyltin results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 3

decreases expression

tributyltin results in decreased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 2

decreases expression

tributyltin results in decreased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 4

increases expression

tributyltin results in increased expression of CXCR4 mRNA

PMID:19371601 PMID:26314263

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b5 type A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CYB5A mRNA

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome b-245 beta chain

increases expression

tributyltin results in increased expression of CYBB protein

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

increases expression

tributyltin results in increased expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

tributyltin results in increased expression of CYP11A1 protein

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

decreases expression
multiple interactions

tributyltin results in decreased expression of CYP11B1 mRNA
[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA

PMID:25765474 PMID:29549738

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions
increases expression

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA
tributyltin results in increased expression of CYP11B2 mRNA

PMID:25765474 PMID:29549738

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

tributyltin results in decreased expression of CYP17A1 mRNA; tributyltin results in decreased expression of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases expression
decreases activity
increases activity

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP19A1 mRNA; [tributyltin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; [tributyltin co-treated with Testosterone] results in increased expression of CYP19A1 mRNA; Finasteride promotes the reaction [[tributyltin co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; tributyltin inhibits the reaction [CYP19A1 protein affects the metabolism of Testosterone]; tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione]; tributyltin promotes the reaction [[Finasteride co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]
tributyltin results in increased expression of CYP19A1 protein
[bisphenol A co-treated with tributyltin] results in increased expression of CYP19A1 protein
tributyltin results in decreased expression of CYP19A1 mRNA
tributyltin results in increased expression of CYP19A1 mRNA; tributyltin results in increased expression of CYP19A1 protein
tributyltin results in decreased activity of CYP19A1 protein
tributyltin results in increased activity of CYP19A1 protein

PMID:11522339 PMID:11751016 PMID:15941851 PMID:16996190 PMID:18310892 More...

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

tributyltin results in increased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

tributyltin results in increased expression of CYP2S1 mRNA

NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303

G

cytochrome P450, family 2, subfamily t, polypeptide 1

decreases expression

tributyltin results in decreased expression of CYP2T1 mRNA

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563

G

cytochrome P450 family 7 subfamily A member 1

increases expression

tributyltin results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cysteinyl leukotriene receptor 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CYSLTR2 mRNA

NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136

G

diazepam binding inhibitor

increases expression

tributyltin results in increased expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

D-box binding PAR bZIP transcription factor

increases expression

tributyltin results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

doublecortin-like kinase 1

increases expression

tributyltin results in increased expression of DCLK1 mRNA

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

doublecortin-like kinase 3

increases expression

tributyltin results in increased expression of DCLK3 mRNA

NCBI chr 8:111,401,544...111,453,999
Ensembl chr 8:111,401,358...111,453,999

G

DNA-damage inducible transcript 3

increases expression

tributyltin results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

tributyltin results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

delta(4)-desaturase, sphingolipid 2

increases expression

tributyltin results in increased expression of DEGS2 mRNA

NCBI chr 6:127,596,063...127,613,293
Ensembl chr 6:127,596,071...127,613,293

G

DENN domain containing 10

increases expression

tributyltin results in increased expression of DENND10 mRNA

NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455

G

DNA fragmentation factor subunit beta

increases response to substance
multiple interactions

DFFB protein results in increased susceptibility to tributyltin
DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP3 protein]; DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP6 protein]; DFFB protein promotes the reaction [tributyltin results in increased cleavage of PARP1 protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

diacylglycerol O-acyltransferase 1

increases expression
multiple interactions

tributyltin results in increased expression of DGAT1 mRNA
[tributyltin co-treated with LHB protein] results in increased expression of DGAT1 mRNA

PMID:23428407 PMID:38630605

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

diacylglycerol O-acyltransferase 2

increases expression

tributyltin results in increased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

dehydrogenase/reductase 9

decreases expression

tributyltin results in decreased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

DEAH-box helicase 35

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DHX35 mRNA

NCBI chr 3:147,450,178...147,507,473
Ensembl chr 3:147,450,163...147,507,451

G

DEAH-box helicase 40

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of DHX40 mRNA
tributyltin results in increased expression of DHX40 mRNA

NCBI chr10:71,584,546...71,621,479
Ensembl chr10:71,583,716...71,621,445

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

tributyltin results in decreased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dickkopf WNT signaling pathway inhibitor 3

increases expression

tributyltin results in increased expression of DKK3 mRNA

NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590

G

delta like non-canonical Notch ligand 1

decreases expression

tributyltin results in decreased expression of DLK1 mRNA

PMID:23322813 PMID:24513447

NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522

G

DNA methyltransferase 1-associated protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DMAP1 mRNA

NCBI chr 5:131,143,726...131,151,760
Ensembl chr 5:131,143,729...131,151,742

G

deleted in malignant brain tumors 1

increases expression

tributyltin results in increased expression of DMBT1 mRNA

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

dentin matrix acidic phosphoprotein 1

decreases expression
multiple interactions

tributyltin results in decreased expression of DMP1 mRNA
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of DMP1 mRNA]

PMID:25777084 PMID:25932594

NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323

G

dynein axonemal intermediate chain 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DNAI4 mRNA

NCBI chr 5:117,787,398...117,876,216
Ensembl chr 5:117,788,464...117,876,127

G

DnaJ heat shock protein family (Hsp40) member C12

decreases expression

tributyltin results in decreased expression of DNAJC12 mRNA

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

DNA methyltransferase 3 beta

decreases expression

tributyltin results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

docking protein 4

increases expression

tributyltin results in increased expression of DOK4 mRNA

NCBI chr19:10,146,520...10,157,187
Ensembl chr19:10,146,474...10,158,203

G

dipeptidase 1

increases expression

tributyltin results in increased expression of DPEP1 mRNA

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

dipeptidase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DPEP2 mRNA

NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954

G

dermatopontin

increases expression

tributyltin results in increased expression of DPT mRNA

NCBI chr13:77,123,224...77,151,646
Ensembl chr13:77,123,115...77,151,639

G

dentin sialophosphoprotein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

dual specificity phosphatase 10

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 13B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DUSP13B mRNA

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

dual specificity tyrosine phosphorylation regulated kinase 1B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DYRK1B mRNA

NCBI chr 1:83,479,168...83,497,011
Ensembl chr 1:83,479,147...83,487,169

G

dysferlin

decreases expression

tributyltin results in decreased expression of DYSF mRNA

NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709

G

ethylmalonyl-CoA decarboxylase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ECHDC1 mRNA

NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319

G

endothelin 1

increases expression

tributyltin results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic elongation factor-2 kinase

increases expression

tributyltin results in increased expression of EEF2K mRNA

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

EGF containing fibulin extracellular matrix protein 1

increases expression

tributyltin results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

early growth response 1

decreases expression

tributyltin results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

tributyltin results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of EGR4 mRNA

NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328

G

EH-domain containing 2

increases expression

tributyltin results in increased expression of EHD2 mRNA

NCBI chr 1:76,639,568...76,658,747
Ensembl chr 1:76,637,482...76,658,783

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

tributyltin results in increased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4B

multiple interactions

tributyltin affects the expression of and results in increased phosphorylation of EIF4B protein

NCBI chr 7:133,206,637...133,228,436

G

eukaryotic translation initiation factor 4E

multiple interactions

tributyltin affects the expression of and results in increased phosphorylation of EIF4E protein

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

endosome-lysosome associated apoptosis and autophagy regulator 1

increases expression

tributyltin results in increased expression of ELAPOR1 mRNA

NCBI chr 2:196,089,199...196,169,055
Ensembl chr 2:196,091,646...196,168,716

G

E74 like ETS transcription factor 3

increases expression

tributyltin results in increased expression of ELF3 mRNA

NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481

G

ETS transcription factor ELK4

increases expression

tributyltin results in increased expression of ELK4 mRNA

NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035

G

ELMO domain containing 3

increases expression

tributyltin results in increased expression of ELMOD3 mRNA

NCBI chr 4:104,614,665...104,653,122
Ensembl chr 4:104,614,676...104,653,053

G

ELOVL fatty acid elongase 3

decreases expression

tributyltin results in decreased expression of ELOVL3 mRNA

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

ELOVL fatty acid elongase 7

increases expression

tributyltin results in increased expression of ELOVL7 mRNA

NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845

G

enamelin

decreases expression
multiple interactions

tributyltin results in decreased expression of ENAM mRNA
Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of ENAM mRNA]

NCBI chr14:19,556,729...19,581,433
Ensembl chr14:19,556,729...19,581,425

G

endonuclease G

increases expression

tributyltin results in increased expression of ENDOG mRNA

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

eomesodermin

decreases expression

tributyltin results in decreased expression of EOMES mRNA

NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316

G

erythrocyte membrane protein band 4.1-like 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of EPB41L1 mRNA

NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721

G

epithelial cell adhesion molecule

increases expression

tributyltin results in increased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

EPM2A interacting protein 1

increases expression
multiple interactions

tributyltin results in increased expression of EPM2AIP1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of EPM2AIP1 mRNA

NCBI chr 8:111,233,871...111,241,219
Ensembl chr 8:111,233,826...111,241,871

G

erb-b2 receptor tyrosine kinase 2

increases expression

tributyltin results in increased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ETS transcription factor ERG

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ERG mRNA

NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871

G

ER membrane-associated RNA degradation

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ERMARD mRNA

NCBI chr 1:55,983,312...56,004,569
Ensembl chr 1:55,983,403...56,002,687

G

estrogen receptor 1

multiple interactions
decreases expression
affects expression
increases expression

tributyltin binds to and results in increased activity of ESR1 protein; tributyltin results in increased expression of and affects the localization of ESR1 protein
tributyltin results in decreased expression of ESR1 protein
tributyltin affects the expression of ESR1 protein
fulvestrant inhibits the reaction [tributyltin affects the expression of ESR1 protein]
Estrogens inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; tributyltin inhibits the reaction [Estrogens results in increased expression of ESR1 protein]
tributyltin results in increased expression of ESR1 mRNA

PMID:23523586 PMID:25819109 PMID:27521499 PMID:28161095 PMID:29908848 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

affects expression

tributyltin affects the expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

electron transfer flavoprotein subunit beta lysine methyltransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ETFBKMT mRNA

NCBI chr 4:182,140,492...182,204,635
Ensembl chr 4:182,140,559...182,150,305

G

electron transfer flavoprotein dehydrogenase

increases expression
multiple interactions

tributyltin results in increased expression of ETFDH mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of ETFDH mRNA

PMID:24848799 PMID:31129395

NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745

G

eva-1 homolog C

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of EVA1C mRNA

NCBI chr11:30,089,510...30,163,596
Ensembl chr11:30,089,365...30,163,596

G

exonuclease 3'-5' domain containing 2

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of EXD2 mRNA
tributyltin results in increased expression of EXD2 mRNA

NCBI chr 6:100,116,867...100,150,452
Ensembl chr 6:100,116,867...100,150,442

G

exonuclease 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

exocyst complex component 3-like 4

increases expression

tributyltin results in increased expression of EXOC3L4 mRNA

NCBI chr 6:130,452,680...130,466,684
Ensembl chr 6:130,452,661...130,466,683

G

exosome component 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of EXOSC3 mRNA

NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060

G

ezrin

increases expression

tributyltin results in increased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

F11 receptor

decreases expression

tributyltin results in decreased expression of F11R mRNA

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

coagulation factor XIII A1 chain

increases expression

tributyltin results in increased expression of F13A1 mRNA

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

F2R like trypsin receptor 1

increases expression

tributyltin results in increased expression of F2RL1 mRNA

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

fatty acid binding protein 3

increases expression

tributyltin results in increased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 4

multiple interactions
increases expression

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of FABP4 protein; diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of FABP4 mRNA]; dibutyldichlorotin inhibits the reaction [tributyltin results in increased expression of FABP4 protein]; T 0070907 inhibits the reaction [tributyltin results in increased expression of FABP4 mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; triphenyltin chloride affects the reaction [tributyltin results in increased expression of FABP4 protein]
tributyltin results in increased expression of FABP4 mRNA; tributyltin results in increased expression of FABP4 protein

PMID:15993011 PMID:21622945 PMID:22197818 PMID:23322813 PMID:23428407 More...

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 5

increases expression

tributyltin results in increased expression of FABP5 mRNA

PMID:23428407 PMID:31939706

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

family with sequence similarity 117, member A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAM117A mRNA

NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343

G

family with sequence similarity 131, member B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM131B mRNA

NCBI chr 4:71,201,037...71,210,292
Ensembl chr 4:71,201,038...71,210,228

G

family with sequence similarity 13, member A

increases expression

tributyltin results in increased expression of FAM13A mRNA

NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860

G

family with sequence similarity 209

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM209 mRNA

NCBI chr 3:161,240,062...161,241,747
Ensembl chr 3:161,240,034...161,241,755

G

family with sequence similarity 227, member A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAM227A mRNA

NCBI chr 7:111,174,362...111,216,513
Ensembl chr 7:111,174,362...111,216,483

G

family with sequence similarity 76, member B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAM76B mRNA

NCBI chr 8:10,689,396...10,711,847
Ensembl chr 8:10,688,963...10,711,861

G

family with sequence similarity 83, member B

increases expression

tributyltin results in increased expression of FAM83B mRNA

NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795

G

family with sequence similarity 98, member A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM98A mRNA

NCBI chr 6:19,874,082...19,888,744
Ensembl chr 6:19,874,071...19,888,742

G

Fas cell surface death receptor

increases expression

tributyltin results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

increases expression
multiple interactions

tributyltin results in increased expression of FASN mRNA
[tributyltin co-treated with LHB protein] results in increased expression of FASN mRNA

PMID:23322813 PMID:28011154 PMID:38630605

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FAT atypical cadherin 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAT4 mRNA

NCBI chr 2:121,927,266...122,056,700
Ensembl chr 2:121,927,942...122,056,707

G

F-box and leucine-rich repeat protein 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FBXL4 mRNA

NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443

G

Fc gamma binding protein

increases expression

tributyltin results in increased expression of FCGBP mRNA

NCBI chr 1:83,374,979...83,413,082
Ensembl chr 1:83,372,127...83,413,083

G

ferrochelatase

decreases activity

tributyltin results in decreased activity of FECH protein

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

FERM domain containing kindlin 1

increases expression

tributyltin results in increased expression of FERMT1 mRNA

NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555

G

fibrinogen alpha chain

decreases expression

tributyltin results in decreased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

decreases expression

tributyltin results in decreased expression of FGB mRNA

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibrinogen gamma chain

decreases expression

tributyltin results in decreased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

fibrinogen-like 2

increases expression

tributyltin results in increased expression of FGL2 mRNA

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

G

FHF complex subunit HOOK interacting protein 1A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FHIP1A mRNA

NCBI chr 2:171,016,951...171,265,715
Ensembl chr 2:171,021,246...171,265,848

G

formin homology 2 domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FHOD1 mRNA

NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356

G

Fli-1 proto-oncogene, ETS transcription factor

increases expression

tributyltin results in increased expression of FLI1 mRNA

NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433

G

fibronectin 1

multiple interactions

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

tributyltin results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

decreases expression

tributyltin results in decreased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box O1

decreases expression

tributyltin results in decreased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

tributyltin inhibits the reaction [Estrogens deficiency results in increased secretion of FSHB protein]
tributyltin results in decreased expression of FSHB mRNA; tributyltin results in decreased expression of FSHB protein

PMID:28161095 PMID:35430282

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of FSHR protein
tributyltin results in increased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

G0/G1switch 2

increases expression

tributyltin results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of G6PC1 mRNA
tributyltin results in increased expression of G6PC1 protein

PMID:31129395 PMID:31306684

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutamate decarboxylase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GAD2 mRNA

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

growth arrest and DNA-damage-inducible, beta

increases expression

tributyltin results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

decreases expression

tributyltin results in decreased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

galanin and GMAP prepropeptide

decreases expression
increases activity

tributyltin results in decreased expression of GAL protein
tributyltin results in increased activity of GAL protein

PMID:27310180 PMID:36319700

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

galactose-3-O-sulfotransferase 3

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of GAL3ST3 mRNA
tributyltin results in decreased expression of GAL3ST3 mRNA

NCBI chr 1:202,593,635...202,603,446
Ensembl chr 1:202,593,692...202,603,445

G

galactokinase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GALK2 mRNA

NCBI chr 3:113,110,057...113,243,014
Ensembl chr 3:113,110,030...113,233,306

G

polypeptide N-acetylgalactosaminyltransferase 12

increases expression

tributyltin results in increased expression of GALNT12 mRNA

NCBI chr 5:61,384,575...61,413,346
Ensembl chr 5:61,384,571...61,413,354

G

polypeptide N-acetylgalactosaminyltransferase 6

increases expression

tributyltin results in increased expression of GALNT6 mRNA

NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661

G

galanin receptor 2

increases expression

tributyltin results in increased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

tributyltin results in decreased expression of GAPDH protein
tributyltin promotes the reaction [Tretinoin results in decreased expression of GAPDH protein]

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GAR1 ribonucleoprotein

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GAR1 mRNA

NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524

G

GATA binding protein 4

increases expression
multiple interactions

tributyltin results in increased expression of GATA4 protein
[bisphenol A co-treated with tributyltin] results in increased expression of GATA4 protein

PMID:31129395 PMID:36319700

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GATA binding protein 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GATA5 mRNA

NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751

G

glutamyl-tRNA amidotransferase subunit C

increases expression

tributyltin results in increased expression of GATC mRNA

NCBI chr12:41,270,096...41,278,067
Ensembl chr12:41,270,087...41,277,995

G

guanylate binding protein 1

increases expression

tributyltin results in increased expression of GBP2B mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

gastrulation brain homeobox 2

decreases expression

tributyltin results in decreased expression of GBX2 mRNA

NCBI chr 9:90,509,633...90,512,212
Ensembl chr 9:90,509,633...90,512,212

G

GRIP and coiled-coil domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GCC2 mRNA

NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613

G

glucagon

decreases secretion
decreases expression

tributyltin results in decreased secretion of GCG protein
tributyltin results in decreased expression of GCG mRNA

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glucagon receptor

decreases expression

tributyltin results in decreased expression of GCGR protein

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

guanine deaminase

increases expression

tributyltin results in increased expression of GDA mRNA

PMID:21683754 PMID:31939706

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

glycerophosphodiester phosphodiesterase domain containing 1

increases expression

tributyltin results in increased expression of GDPD1 mRNA

NCBI chr10:71,840,497...71,883,936
Ensembl chr10:71,840,497...71,883,850

G

GTP binding protein overexpressed in skeletal muscle

increases expression

tributyltin results in increased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

guided entry of tail-anchored proteins factor 3, ATPase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GET3 mRNA

NCBI chr19:23,130,109...23,138,196
Ensembl chr19:23,130,109...23,138,193

G

glial fibrillary acidic protein

decreases expression
increases expression
multiple interactions

tributyltin results in decreased expression of GFAP protein
tributyltin results in increased expression of GFAP protein
Phycocyanin inhibits the reaction [tributyltin results in increased expression of GFAP protein]

PMID:23743147 PMID:26079211

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gamma-glutamylamine cyclotransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GGACT mRNA

NCBI chr15:99,969,246...99,998,343
Ensembl chr15:99,968,282...99,993,455

G

gypsy retrotransposon integrase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GIN1 mRNA

NCBI chr 9:98,293,596...98,315,155
Ensembl chr 9:98,293,597...98,315,848

G

GIPC PDZ domain containing family, member 2

increases expression

tributyltin results in increased expression of GIPC2 mRNA

NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236

G

gap junction protein, alpha 1

decreases expression

tributyltin results in decreased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glycerol kinase

increases expression

tributyltin results in increased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

glycine receptor, alpha 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GLRA3 mRNA

NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753

G

G protein subunit gamma 11

increases expression

tributyltin results in increased expression of GNG11 mRNA

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

gonadotropin releasing hormone 1

multiple interactions
decreases expression

tributyltin inhibits the reaction [Estrogens deficiency results in increased expression of GNRH1 mRNA]; tributyltin inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]
tributyltin results in decreased expression of GNRH1 mRNA

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

GON7 subunit of KEOPS complex

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GON7 mRNA

NCBI chr 6:121,882,565...121,898,452
Ensembl chr 6:121,885,694...121,898,643
Ensembl chr 6:121,885,694...121,898,643

G

glycerol-3-phosphate acyltransferase 3

increases expression

tributyltin results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

glypican 6

increases expression

tributyltin results in increased expression of GPC6 mRNA

NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006

G

glycoprotein nmb

decreases expression

tributyltin results in decreased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor 155

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GPR155 mRNA

NCBI chr 3:58,216,422...58,270,350
Ensembl chr 3:58,216,423...58,270,275

G

G protein-coupled receptor 158

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GPR158 mRNA

NCBI chr17:83,777,625...84,244,428
Ensembl chr17:83,834,569...84,244,428

G

G protein-coupled receptor 45

decreases expression

tributyltin results in decreased expression of GPR45 mRNA

NCBI chr 9:45,221,364...45,309,713
Ensembl chr 9:45,306,237...45,309,706

G

glutamic--pyruvic transaminase 2

decreases expression

tributyltin results in decreased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 6

increases expression

tributyltin results in increased expression of GPX6 mRNA

NCBI chr17:43,408,472...43,416,091
Ensembl chr17:43,408,472...43,416,091

G

growth factor receptor bound protein 14

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GRB14 mRNA

NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889

G

gremlin 2, DAN family BMP antagonist

increases expression

tributyltin results in increased expression of GREM2 mRNA

NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615

G

glutamate ionotropic receptor AMPA type subunit 1

decreases expression

tributyltin results in decreased expression of GRIA1 mRNA

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

tributyltin results in decreased expression of GRIA2 mRNA; tributyltin results in decreased expression of GRIA2 protein

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

tributyltin results in increased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor AMPA type subunit 4

increases expression

tributyltin results in increased expression of GRIA4 mRNA

NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

tributyltin results in decreased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

tributyltin results in decreased expression of GRIN2A mRNA

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression

tributyltin results in increased expression of GRIN2B mRNA

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

G protein-coupled receptor kinase 5

decreases expression

tributyltin results in decreased expression of GRK5 mRNA

NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701

G

glutaredoxin and cysteine rich domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GRXCR2 mRNA

NCBI chr18:33,984,689...33,998,094
Ensembl chr18:33,984,689...33,998,094

G

gasdermin E

increases expression

tributyltin results in increased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

glutathione-disulfide reductase

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of GSR protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase omega 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

GTP binding protein 6 (putative)

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

G

guanylate cyclase 2C

increases expression

tributyltin results in increased expression of GUCY2C mRNA

NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092

G

guanylate cyclase 2E

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GUCY2D mRNA

NCBI chr10:53,954,918...53,975,576
Ensembl chr10:53,959,010...53,974,067

G

granzyme A

increases expression

tributyltin results in increased expression of GZMA mRNA

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

H2A clustered histone 4

increases expression

tributyltin results in increased expression of H2AC4 mRNA

NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381

G

H2A.X variant histone

multiple interactions
increases expression
increases phosphorylation

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of H2AX protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]

PMID:26079211 PMID:31401084 PMID:36319700

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

H3 clustered histone 1

increases expression

tributyltin results in increased expression of H3C1 mRNA

NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856

G

hydroxyacyl-CoA dehydrogenase

increases expression

tributyltin results in increased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression

tributyltin results in increased expression of HADHA mRNA

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

tributyltin results in increased expression of HADHB mRNA

PMID:23428407 PMID:24848799

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

hepcidin antimicrobial peptide

decreases expression

tributyltin results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

heart and neural crest derivatives expressed 1

decreases expression

tributyltin results in decreased expression of HAND1 mRNA

NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213

G

hydroxyacid oxidase 2

increases expression

tributyltin results in increased expression of HAO2 mRNA

NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425

G

histone acetyltransferase 1

increases activity

tributyltin results in increased activity of HAT1 protein

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

haloacid dehalogenase like hydrolase domain containing 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of HDHD5 mRNA

NCBI chr 4:153,701,026...153,753,303
Ensembl chr 4:153,718,791...153,753,277

G

HECT domain E3 ubiquitin protein ligase 2

increases expression

tributyltin results in increased expression of HECTD2 mRNA

NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487

G

hephaestin

increases expression

tributyltin results in increased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

Holliday junction recognition protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HJURP mRNA

NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728

G

hexokinase domain containing 1

increases expression

tributyltin results in increased expression of HKDC1 mRNA

NCBI chr20:30,335,322...30,373,792
Ensembl chr20:30,335,628...30,373,867

G

5-hydroxymethylcytosine binding, ES cell specific

increases expression

tributyltin results in increased expression of HMCES mRNA

NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616

G

high mobility group AT-hook 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HMGA1 mRNA

NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of HMGCS2 mRNA
tributyltin results in increased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

hyaluronan-mediated motility receptor

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

increases expression

tributyltin results in increased expression of HMOX1 protein

PMID:28707438 PMID:36858641

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein F

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of HNRNPF mRNA

NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038

G

homeobox A2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HOXA2 mRNA

NCBI chr 4:81,262,668...81,266,970
Ensembl chr 4:81,262,768...81,265,044

G

15-hydroxyprostaglandin dehydrogenase

increases expression

tributyltin results in increased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

histamine receptor H 1

decreases expression

tributyltin results in decreased expression of HRH1 mRNA

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H3

decreases expression

tributyltin results in decreased expression of HRH3 mRNA

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

G

homologous recombination factor with OB-fold

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HROB mRNA

NCBI chr10:87,206,017...87,222,483
Ensembl chr10:87,206,049...87,222,483

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity
multiple interactions
increases expression

tributyltin results in decreased activity of HSD11B2 protein
Cycloheximide promotes the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; LG 100754 inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 protein]; tributyltin results in increased expression of and results in increased activity of HSD11B2 protein

PMID:16184081 PMID:22796344 PMID:31927052

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxysteroid (17-beta) dehydrogenase 1

increases activity
increases expression

tributyltin results in increased activity of HSD17B1 protein
tributyltin results in increased expression of HSD17B1 mRNA

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of HSD17B3 mRNA
tributyltin results in decreased expression of HSD17B3 mRNA; tributyltin results in decreased expression of HSD17B3 protein

PMID:31129395 PMID:35430282

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxysteroid (17-beta) dehydrogenase 6

increases expression

tributyltin results in increased expression of HSD17B6 mRNA

NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression
increases expression

tributyltin results in decreased expression of HSD3B1 mRNA; tributyltin results in decreased expression of HSD3B1 protein
tributyltin results in increased expression of HSD3B2 mRNA

PMID:31939706 PMID:35430282

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

increases expression
decreases expression

tributyltin results in increased expression of HSD3B2 mRNA
tributyltin results in decreased expression of HSD3B2 mRNA

PMID:23523586 PMID:29549738

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

decreases expression

tributyltin results in decreased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

multiple interactions
decreases expression
increases expression

4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]
tributyltin results in decreased expression of HSPA5 mRNA

PMID:23743301 PMID:27678064

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

decreases expression

tributyltin results in decreased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 8

increases expression

tributyltin results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

5-hydroxytryptamine receptor 2A

decreases expression

tributyltin results in decreased expression of HTR2A mRNA

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

intercellular adhesion molecule 1

increases expression

tributyltin results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 3

decreases expression

tributyltin results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

increases expression
multiple interactions

tributyltin results in increased expression of IDH3A mRNA
IDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]

PMID:23428407 PMID:26961604

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

immediate early response 3

increases expression

tributyltin results in increased expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

immediate early response 3 interacting protein 1, pseudogene 1

increases expression
multiple interactions

tributyltin results in increased expression of IER3IP1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of IER3IP1 mRNA

NCBI chr 4:132,342,131...132,342,625
Ensembl chr 4:132,332,180...132,342,316

G

interferon, alpha-inducible protein 27 like 2A

increases expression

tributyltin results in increased expression of IFI27L2A mRNA

NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360

G

interferon induced transmembrane protein 3

increases expression

tributyltin results in increased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

interferon alpha and beta receptor subunit 2

increases expression

tributyltin results in increased expression of IFNAR2 mRNA

NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124

G

interferon gamma

affects expression
multiple interactions

tributyltin affects the expression of IFNG mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IFNG protein]; tributyltin results in increased expression of and results in increased secretion of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

immunoglobulin superfamily, DCC subclass, member 4

increases expression

tributyltin results in increased expression of IGDCC4 mRNA

NCBI chr 8:65,621,893...65,657,651
Ensembl chr 8:65,621,897...65,657,648

G

insulin-like growth factor binding protein 1

decreases expression

tributyltin results in decreased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

immunoglobulin kappa variable like 15

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of IGKVL15 mRNA

NCBI chr19:3,093,174...3,093,807
Ensembl chr19:3,093,182...3,093,807

G

immunoglobulin superfamily, member 11

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of IGSF11 mRNA

NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348

G

immunoglobulin superfamily, member 23

increases expression

tributyltin results in increased expression of IGSF23 mRNA

NCBI chr 1:79,591,059...79,606,323
Ensembl chr 1:79,592,088...79,610,438

G

immunoglobulin superfamily, member 9

increases expression

tributyltin results in increased expression of IGSF9 mRNA

NCBI chr13:84,948,643...84,965,616
Ensembl chr13:84,948,619...84,965,607

G

Indian hedgehog signaling molecule

increases expression

tributyltin results in increased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

interleukin 10

increases expression

tributyltin results in increased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

decreases expression

tributyltin results in decreased expression of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of IL15 protein

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 16

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of IL16 protein

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 18

multiple interactions

[tributyltin co-treated with LHB protein] results in increased secretion of IL18 protein

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions
increases expression

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [tributyltin results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein]; Rotenone inhibits the reaction [tributyltin results in increased expression of IL1A protein]

PMID:8875956 PMID:9221826

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

affects secretion
increases expression
multiple interactions

tributyltin affects the secretion of IL1B protein
tributyltin results in increased expression of IL1B mRNA
tributyltin results in increased expression of IL1B mRNA; tributyltin results in increased expression of IL1B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [tributyltin affects the secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of IL1B mRNA]; CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL1B protein]; tributyltin results in increased expression of and results in increased secretion of IL1B protein; U 0126 affects the reaction [tributyltin affects the secretion of IL1B protein]

PMID:25382723 PMID:29951691 PMID:35405286 PMID:36319700

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

decreases expression

tributyltin results in decreased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 3 receptor subunit alpha

increases expression

tributyltin results in increased expression of IL3RA mRNA

NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484

G

interleukin 4

decreases expression

tributyltin results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5 receptor subunit alpha

decreases expression

tributyltin results in decreased expression of IL5RA mRNA

NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544

G

interleukin 6

increases expression
multiple interactions

tributyltin results in increased expression of IL6 protein
tributyltin results in increased expression of IL6 mRNA; tributyltin results in increased expression of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of IL6 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of IL6 protein]; CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL6 protein]; tributyltin results in increased expression of and results in increased secretion of IL6 protein

PMID:23743147 PMID:29951691 PMID:30172001 PMID:35405286

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 9

multiple interactions

[tributyltin co-treated with LHB protein] results in increased secretion of IL9 protein

NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895

G

interphotoreceptor matrix proteoglycan 2

decreases expression

tributyltin results in decreased expression of IMPG2 mRNA

NCBI chr11:44,318,836...44,418,382
Ensembl chr11:44,318,836...44,418,382

G

inhibin subunit beta B

increases expression

tributyltin results in increased expression of INHBB mRNA

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

insulin 1

increases expression
multiple interactions
increases secretion

tributyltin results in increased expression of INS1 mRNA; tributyltin results in increased expression of INS1 protein
Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin results in increased secretion of INS1 protein]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]
tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]

PMID:27384973 PMID:28161095 PMID:28180948 PMID:28397090 PMID:30172001 More...

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions
increases expression

tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]
tributyltin results in increased expression of INS2 mRNA
[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA; [tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of DMP1 mRNA]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased secretion of TNFRSF11B protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]; tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]

PMID:22197818 PMID:25932594 PMID:28180948 PMID:31016361 PMID:31306684 More...

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin induced gene 2

decreases expression

tributyltin results in decreased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

insulin receptor

affects methylation
multiple interactions

tributyltin affects the methylation of INSR gene
tributyltin results in decreased expression of and results in decreased phosphorylation of INSR protein

PMID:28011154 PMID:28397090

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

interferon regulatory factor 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of IRF5 mRNA

NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267

G

insulin receptor substrate 1

multiple interactions
increases expression

tributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein
tributyltin results in increased expression of IRS1 mRNA

PMID:28397090 PMID:30027469

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

isochorismatase domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ISOC1 mRNA

NCBI chr18:52,158,790...52,179,206
Ensembl chr18:52,158,790...52,178,703

G

integrin subunit alpha 4

increases expression

tributyltin results in increased expression of ITGA4 mRNA

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha 6

increases expression

tributyltin results in increased expression of ITGA6 mRNA

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

integrin subunit alpha L

increases expression

tributyltin results in increased expression of ITGAL mRNA

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

integrin subunit alpha M

multiple interactions
increases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of ITGAM mRNA]
[Phycocyanin co-treated with tributyltin] results in increased expression of ITGAM protein

PMID:22749964 PMID:26079211

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 2

increases expression
multiple interactions
affects localization

tributyltin results in increased expression of ITGB2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin affects the localization of ITGB2 protein]

PMID:20883105 PMID:26314263

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 4

increases expression

tributyltin results in increased expression of ITGB4 mRNA

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

intelectin 1

increases expression

tributyltin results in increased expression of ITLN1 mRNA

NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227

G

inositol 1,4,5-trisphosphate receptor, type 3

increases expression

tributyltin results in increased expression of ITPR3 mRNA

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

intersectin 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ITSN2 mRNA

NCBI chr 6:27,616,645...27,727,373
Ensembl chr 6:27,600,406...27,727,124

G

junctional adhesion molecule 2

increases expression

tributyltin results in increased expression of JAM2 mRNA

NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063

G

junctional adhesion molecule 3

increases expression

tributyltin results in increased expression of JAM3 mRNA

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

joining chain of multimeric IgA and IgM

increases expression

tributyltin results in increased expression of JCHAIN mRNA

NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298

G

junctional cadherin complex regulator

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of JHY mRNA

NCBI chr 8:41,276,501...41,333,383
Ensembl chr 8:41,276,491...41,333,514

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation

tributyltin results in increased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

tributyltin results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

KN motif and ankyrin repeat domains 2

increases expression

tributyltin results in increased expression of KANK2 mRNA

NCBI chr 8:20,311,676...20,341,107
Ensembl chr 8:20,311,676...20,340,900

G

kelch repeat and BTB domain containing 11

increases expression

tributyltin results in increased expression of KBTBD11 mRNA

NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736

G

potassium two pore domain channel subfamily K member 3

increases expression

tributyltin results in increased expression of KCNK3 mRNA

NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153

G

potassium voltage-gated channel subfamily Q member 1

increases expression

tributyltin results in increased expression of KCNQ1 mRNA

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

G

potassium channel tetramerization domain containing 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of KCTD8 mRNA

NCBI chr14:38,773,274...39,018,182
Ensembl chr14:38,773,634...39,017,554

G

Kelch-like ECH-associated protein 1

decreases expression

tributyltin results in decreased expression of KEAP1 protein

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kinesin family member 2A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of KIF2A mRNA

NCBI chr 2:38,367,998...38,431,237
Ensembl chr 2:38,367,998...38,431,508

G

kinesin family member 3B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of KIF3B mRNA

NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963

G

KiSS-1 metastasis-suppressor

multiple interactions

tributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]

NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612

G

KLF transcription factor 15

decreases expression

tributyltin results in decreased expression of KLF15 mRNA

NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374

G

KLF transcription factor 2

increases expression

tributyltin results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

KLF transcription factor 4

increases expression

tributyltin results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kelch-like family member 9

increases expression

tributyltin results in increased expression of KLHL9 mRNA

NCBI chr 5:103,333,747...103,337,931

G

kininogen 1

increases expression

tributyltin results in increased expression of KNG1 mRNA

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

kinetochore-localized astrin/SPAG5 binding protein

decreases expression

tributyltin results in decreased expression of KNSTRN mRNA

NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715

G

keratin 19

increases expression

tributyltin results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 79

increases expression

tributyltin results in increased expression of KRT79 mRNA

NCBI chr 7:133,056,710...133,067,750
Ensembl chr 7:133,056,709...133,067,705

G

kinase suppressor of ras 1

increases expression

tributyltin results in increased expression of KSR1 mRNA

NCBI chr10:63,961,771...64,098,076
Ensembl chr10:63,961,759...64,098,076

G

lysosomal-associated membrane protein 3

decreases expression

tributyltin results in decreased expression of LAMP3 mRNA

NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784

G

leucyl-tRNA synthetase 2, mitochondrial

affects expression

tributyltin affects the expression of LARS2 mRNA

NCBI chr 8:123,010,271...123,106,395
Ensembl chr 8:123,010,293...123,106,395

G

leptin

increases expression
multiple interactions
decreases expression
increases secretion

tributyltin results in increased expression of LEP mRNA
tributyltin results in increased expression of LEP protein
[Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein
tributyltin results in decreased expression of LEP protein
tributyltin results in increased secretion of LEP protein

PMID:27310180 PMID:28011154 PMID:28161095 PMID:29787037 PMID:30172001

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

decreases expression

tributyltin results in decreased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

LETM1 domain containing 1

increases expression

tributyltin results in increased expression of LETMD1 mRNA

NCBI chr 7:131,584,241...131,597,797
Ensembl chr 7:131,584,259...131,597,796

G

galectin 4

increases expression

tributyltin results in increased expression of LGALS4 mRNA

NCBI chr 1:84,124,766...84,132,481
Ensembl chr 1:84,124,764...84,132,481

G

luteinizing hormone subunit beta

multiple interactions
decreases expression
increases secretion
decreases secretion

[bisphenol A co-treated with tributyltin] results in increased secretion of LHB protein; tributyltin inhibits the reaction [Estrogens deficiency results in increased secretion of LHB protein]; tributyltin inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]; tributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]
[tributyltin co-treated with LHB protein] results in decreased secretion of CCL5 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of CCL8 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of IL15 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of IL16 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of PDGFAA protein; [tributyltin co-treated with LHB protein] results in increased expression of ASCL1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of DGAT1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of FASN mRNA; [tributyltin co-treated with LHB protein] results in increased expression of PLIN1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of PNPLA2 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of SREBF1 mRNA; [tributyltin co-treated with LHB protein] results in increased secretion of IL18 protein; [tributyltin co-treated with LHB protein] results in increased secretion of IL9 protein
tributyltin results in decreased expression of LHB mRNA; tributyltin results in decreased expression of LHB protein
tributyltin results in increased secretion of LHB protein
tributyltin results in decreased secretion of LHB protein

PMID:28161095 PMID:31129395 PMID:35430282 PMID:38630605

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

increases expression

tributyltin results in increased expression of LHCGR mRNA; tributyltin results in increased expression of LHCGR protein

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

lon peptidase 1, mitochondrial

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of LONP1 mRNA

NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771

G

lysyl oxidase

increases expression

tributyltin results in increased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lysyl oxidase-like 2

increases expression

tributyltin results in increased expression of LOXL2 mRNA

NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067

G

lysyl oxidase-like 4

decreases expression

tributyltin results in decreased expression of LOXL4 mRNA

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322

G

lysophosphatidylcholine acyltransferase 3

increases expression

tributyltin results in increased expression of LPCAT3 mRNA

NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880

G

lipin 1

increases expression

tributyltin results in increased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

lipoprotein lipase

multiple interactions
increases expression

T 0070907 inhibits the reaction [tributyltin results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]

PMID:22197818 PMID:23322813 PMID:24513447 PMID:28011154 PMID:29787037

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

leucine rich repeats and calponin homology domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRCH2 mRNA

NCBI chr X:111,091,728...111,174,225
Ensembl chr X:111,092,814...111,174,210

G

leucine rich repeat and fibronectin type III domain containing 3

decreases expression

tributyltin results in decreased expression of LRFN3 mRNA

NCBI chr 1:85,616,862...85,623,725
Ensembl chr 1:85,616,868...85,623,725

G

LDL receptor related protein 11

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRP11 mRNA

NCBI chr 1:2,048,307...2,108,115
Ensembl chr 1:2,079,438...2,108,110

G

LDL receptor related protein 2

decreases expression

tributyltin results in decreased expression of LRP2 mRNA

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

leucine rich repeat containing 1

increases expression

tributyltin results in increased expression of LRRC1 mRNA

NCBI chr 8:78,239,897...78,407,347
Ensembl chr 8:78,239,900...78,406,490

G

leucine rich repeat containing 69

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRRC69 mRNA

NCBI chr 5:28,023,591...28,181,963
Ensembl chr 5:28,023,593...28,214,384

G

leucine rich repeat containing 8 VRAC subunit B

increases expression

tributyltin results in increased expression of LRRC8B mRNA

NCBI chr14:4,350,462...4,416,336
Ensembl chr14:4,354,508...4,416,311

G

leucine-rich repeats and death domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRRD1 mRNA

NCBI chr 4:30,263,147...30,293,119
Ensembl chr 4:30,264,862...30,293,173

G

leucine-rich repeats and transmembrane domains 1

increases expression

tributyltin results in increased expression of LRTM1 mRNA

NCBI chr16:4,210,343...4,217,843

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of LSM2 mRNA

NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266

G

lactotransferrin

increases expression

tributyltin results in increased expression of LTF mRNA

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

Ly49 inhibitory receptor 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LY49I4 mRNA

NCBI chr 4:164,166,784...164,188,380
Ensembl chr 4:164,122,072...164,341,692

G

lymphocyte antigen 6 family member D

decreases expression

tributyltin results in decreased expression of LY6D mRNA

NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733

G

MAF bZIP transcription factor A

decreases expression

tributyltin results in decreased expression of MAFA mRNA

NCBI chr 7:107,432,292...107,435,084
Ensembl chr 7:107,433,605...107,434,690

G

MAGE family member A4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MAGEA4 mRNA

NCBI chr  X:150,035,874...150,038,095
Ensembl chr  X:150,032,515...150,038,086
Ensembl chr  X:150,032,515...150,038,086
Ensembl chr  X:150,032,515...150,038,086
Ensembl chr  X:150,032,515...150,038,086

G

MAGE family member B18

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MAGEB18 mRNA

NCBI chr X:56,885,991...56,888,245
Ensembl chr X:56,885,991...56,888,245

G

mitogen activated protein kinase kinase 3

decreases expression

tributyltin results in decreased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

tributyltin results in increased expression of and results in increased phosphorylation of MAP3K5 protein

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen-activated protein kinase kinase kinase 6

decreases expression

tributyltin results in decreased expression of MAP3K6 mRNA

NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212

G

mitogen activated protein kinase kinase kinase 7

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of MAP3K7 mRNA
tributyltin results in increased expression of MAP3K7 mRNA

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

tributyltin results in decreased expression of MAP4K4 mRNA

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen activated protein kinase 1

multiple interactions
increases expression
increases phosphorylation
increases activity
decreases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK1 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]
tributyltin results in increased expression of MAPK1 protein
tributyltin results in decreased expression of MAPK1 mRNA

PMID:11042092 PMID:18989867 PMID:22223438 PMID:23523586 PMID:23743147 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 12

decreases expression

tributyltin results in decreased expression of MAPK12 mRNA

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen activated protein kinase 14

increases expression

tributyltin results in increased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases expression
increases phosphorylation
increases activity

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK3 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK3 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK3 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]
tributyltin results in increased expression of MAPK3 protein

PMID:11042092 PMID:18989867 PMID:22223438 PMID:23523586 PMID:23743147 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation

tributyltin results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microtubule-associated protein tau

increases cleavage
multiple interactions
increases degradation

tributyltin results in increased cleavage of MAPT protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of MAPT protein]

PMID:23743147 PMID:33481012

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MBL associated serine protease 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

G

melanocortin 2 receptor

multiple interactions

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of MC2R mRNA

NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488

G

MAPK regulated co-repressor interacting protein 2

increases expression

tributyltin results in increased expression of MCRIP2 mRNA

NCBI chr10:14,883,813...14,888,784
Ensembl chr10:14,883,813...14,894,021

G

mitochondrial calcium uniporter regulator 1

increases expression

tributyltin results in increased expression of MCUR1 mRNA

NCBI chr17:21,142,526...21,159,651
Ensembl chr17:21,141,602...21,159,651

G

malate dehydrogenase 2

increases expression

tributyltin results in increased expression of MDH2 mRNA

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

malic enzyme 2

increases expression

tributyltin results in increased expression of ME2 mRNA

NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987

G

malic enzyme 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

G

mediator complex subunit 12L

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MED12L mRNA

NCBI chr 2:143,253,048...143,576,507
Ensembl chr 2:143,252,139...143,573,741

G

mediator complex subunit 13

increases expression

tributyltin results in increased expression of MED13 mRNA

NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242

G

mediator complex subunit 18

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MED18 mRNA

NCBI chr 5:144,663,316...144,668,652
Ensembl chr 5:144,663,252...144,668,635

G

mediator complex subunit 29

decreases expression

tributyltin results in decreased expression of MED29 mRNA

NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365

G

mesenchyme homeobox 1

increases expression

tributyltin results in increased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

meprin A subunit beta

increases expression

tributyltin results in increased expression of MEP1B mRNA

NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840

G

mesoderm posterior bHLH transcription factor 1

decreases expression

tributyltin results in decreased expression of MESP1 mRNA

NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875

G

methyltransferase 1, tRNA methylguanosine

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of METTL1 mRNA

NCBI chr 7:62,864,860...62,869,202
Ensembl chr 7:62,864,853...62,869,202

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

increases expression

tributyltin results in increased expression of MGAT4A mRNA

NCBI chr 9:39,673,427...39,786,747
Ensembl chr 9:39,673,430...39,766,890

G

monoglyceride lipase

increases expression

tributyltin results in increased expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

MIB E3 ubiquitin protein ligase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MIB1 mRNA

NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

tributyltin results in increased expression of MICAL1 mRNA

NCBI chr20:44,974,137...44,986,089
Ensembl chr20:44,974,138...44,986,089

G

MHC class I polypeptide-related sequence B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MICB mRNA

NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827

G

mitotic spindle positioning

increases expression

tributyltin results in increased expression of MISP mRNA

NCBI chr 7:9,870,390...9,886,541
Ensembl chr 7:9,870,444...9,886,541

G

membrane metallo-endopeptidase

increases expression

tributyltin results in increased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 12

decreases expression

tributyltin results in decreased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

increases expression

tributyltin results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

increases expression

tributyltin results in increased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MMP8 mRNA

NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520

G

matrix metallopeptidase 9

multiple interactions

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

monoacylglycerol O-acyltransferase 2

increases expression

tributyltin results in increased expression of MOGAT2 mRNA

NCBI chr 1:153,521,813...153,545,756
Ensembl chr 1:153,521,815...153,545,756

G

monooxygenase, DBH-like 1

decreases expression

tributyltin results in decreased expression of MOXD1 mRNA

NCBI chr 1:21,075,124...21,165,348
Ensembl chr 1:21,075,122...21,161,779

G

mitochondrial pyruvate carrier 2

increases expression

tributyltin results in increased expression of MPC2 mRNA

NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664

G

myeloperoxidase

increases activity

tributyltin results in increased activity of MPO protein

PMID:28161095 PMID:29908848 PMID:30172001

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallophosphoesterase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MPPE1 mRNA

NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553

G

MPV17 mitochondrial inner membrane protein like

increases expression
multiple interactions

tributyltin results in increased expression of MPV17L mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of MPV17L mRNA

NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649

G

melanocortin 2 receptor accessory protein

increases expression

tributyltin results in increased expression of MRAP mRNA

NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024

G

mitochondrial ribosomal protein L18

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MRPL18 mRNA

NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987

G

mitochondrial ribosomal protein L33

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MRPL33 mRNA

NCBI chr 6:24,825,800...24,833,994
Ensembl chr 6:24,825,827...24,833,834

G

mitochondrial ribosomal protein S33

increases expression
multiple interactions

tributyltin results in increased expression of MRPS33 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of MRPS33 mRNA

NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428

G

membrane spanning 4-domains A8

increases expression

tributyltin results in increased expression of MS4A8A mRNA

NCBI chr 1:207,730,665...207,744,260
Ensembl chr 1:207,730,665...207,744,324

G

macrophage stimulating 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MST1 mRNA

NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416

G

msh homeobox 1

multiple interactions
decreases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of MSX1 mRNA]

NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966

G

mitochondrially encoded ATP synthase membrane subunit 6

increases response to substance

ATP6 gene mutant form results in increased susceptibility to tributyltin

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

mitochondrially encoded ATP synthase membrane subunit 8

decreases expression

tributyltin results in decreased expression of ATP8 mRNA

NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961

G

metallothionein 1

decreases expression

tributyltin results in decreased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 2A

decreases expression

tributyltin results in decreased expression of MT2 mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

methylenetetrahydrofolate reductase

decreases expression

tributyltin results in decreased expression of MTHFR mRNA

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

melatonin receptor 1A

decreases expression

tributyltin results in decreased expression of MTNR1A mRNA

NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919

G

mechanistic target of rapamycin kinase

decreases phosphorylation
decreases expression

tributyltin results in decreased phosphorylation of MTOR protein
tributyltin results in decreased expression of MTOR

PMID:20371977 PMID:26961604

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

myotrophin

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MTPN mRNA

NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724

G

microsomal triglyceride transfer protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

max dimerization protein 1

increases expression

tributyltin results in increased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

Max dimerization protein 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MXD4 mRNA

NCBI chr14:76,562,105...76,576,224
Ensembl chr14:76,561,774...76,576,221

G

MYD88, innate immune signal transduction adaptor

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myosin XVB

increases expression

tributyltin results in increased expression of MYO15B mRNA

NCBI chr10:101,088,734...101,126,159
Ensembl chr10:101,104,209...101,125,693

G

myosin VC

increases expression

tributyltin results in increased expression of MYO5C mRNA

NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483

G

myosin VIIb

increases expression

tributyltin results in increased expression of MYO7B mRNA

NCBI chr18:23,588,307...23,669,841
Ensembl chr18:23,588,307...23,669,809

G

nascent polypeptide associated complex subunit alpha

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NACA mRNA

NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992

G

N-acetyl-alpha-glucosaminidase

increases activity

tributyltin results in increased activity of NAGLU protein

NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972

G

nicotinamide phosphoribosyltransferase

increases expression

tributyltin results in increased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

N-acetyltransferase 8 (GCN5-related) family member 5

decreases expression

tributyltin results in decreased expression of NAT8F5 mRNA

NCBI chr 4:118,260,323...118,285,038
Ensembl chr 4:118,260,252...118,285,704

G

neurobeachin-like 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of NBEAL2 mRNA

NCBI chr 8:110,603,220...110,633,612
Ensembl chr 8:110,599,389...110,633,707

G

neural cell adhesion molecule 1

affects localization
multiple interactions

tributyltin affects the localization of NCAM1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin affects the localization of NCAM1 protein]

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

non-SMC condensin II complex, subunit H2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of NCAPH2 mRNA

NCBI chr 7:120,422,926...120,439,942
Ensembl chr 7:120,422,956...120,439,938

G

nuclear receptor co-repressor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NCOR1 mRNA

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

nudE neurodevelopment protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NDE1 mRNA

NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869

G

N-myc downstream regulated 1

increases expression

tributyltin results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

Ndufa4, mitochondrial complex associated

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NDUFA4 mRNA

NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

tributyltin results in increased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

NEDD4 like E3 ubiquitin protein ligase

decreases expression

tributyltin results in decreased expression of NEDD4L mRNA

NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137

G

neurofilament heavy chain

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of NEFH protein]

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurofilament medium chain

increases degradation
multiple interactions

tributyltin results in increased degradation of NEFM protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of NEFM protein]

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

nei-like DNA glycosylase 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of NEIL3 mRNA

NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527

G

neuraminidase 3

decreases expression

tributyltin results in decreased expression of NEU3 mRNA

NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813

G

neuralized E3 ubiquitin protein ligase 3

increases expression

tributyltin results in increased expression of NEURL3 mRNA

NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649

G

neurofibromin 1

increases expression

tributyltin results in increased expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

nuclear factor of activated T-cells 1

multiple interactions

Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases localization
increases expression

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]
tributyltin results in increased localization of NFE2L2 protein
PRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]

PMID:24055800 PMID:25895139 PMID:26079211 PMID:28707438 PMID:36858641

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor, interleukin 3 regulated

decreases expression

tributyltin results in decreased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

nuclear factor kappa B subunit 1

increases expression

tributyltin results in increased expression of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

affects expression
decreases expression

tributyltin affects the expression of NFKBIA mRNA
tributyltin results in decreased expression of NFKBIA protein

PMID:27678064 PMID:30172001

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

neuronal guanine nucleotide exchange factor

increases expression

tributyltin results in increased expression of NGEF mRNA

NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914

G

NIPA-like domain containing 2

increases expression

tributyltin results in increased expression of NIPAL2 mRNA

NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:65,774,477...65,884,807

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions
decreases expression

Tretinoin promotes the reaction [tributyltin results in decreased expression of NME2 protein]

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538

G

nocturnin

increases expression

tributyltin results in increased expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

nucleolar protein 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NOL4 mRNA

NCBI chr18:13,932,499...14,294,873
Ensembl chr18:13,932,510...14,296,286

G

nitric oxide synthase 1

multiple interactions
decreases activity

CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]; tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 1 adaptor protein

decreases expression

tributyltin results in decreased expression of NOS1AP mRNA

NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949

G

nitric oxide synthase 2

increases expression

tributyltin results in increased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases expression
multiple interactions

tributyltin results in decreased expression of NOS3 protein
tributyltin results in decreased expression of and results in increased phosphorylation of NOS3 protein

PMID:26873547 PMID:34902535

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

neuronal PAS domain protein 2

decreases expression

tributyltin results in decreased expression of NPAS2 mRNA

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

neuropeptide Y

decreases expression

tributyltin results in decreased expression of NPY protein

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 1, group D, member 1

increases expression

tributyltin results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group D, member 2

increases expression

tributyltin results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions
increases expression

tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]
tributyltin results in increased expression of NR1H3 mRNA

PMID:23428407 PMID:24848799 PMID:25932594 PMID:28011154

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

tributyltin binds to and results in increased activity of NR1I2 protein
tributyltin binds to and results in decreased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

tributyltin results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

tributyltin results in decreased expression of NR5A1 mRNA; tributyltin results in decreased expression of NR5A1 protein

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

nardilysin convertase

decreases expression

tributyltin results in decreased expression of NRDC mRNA

NCBI chr 5:123,755,807...123,818,910
Ensembl chr 5:123,755,806...123,818,595

G

neuronal regeneration related protein

increases expression

tributyltin results in increased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

NSE3 homolog, SMC5-SMC6 complex component

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NSMCE3 mRNA

NCBI chr 1:118,401,302...118,402,629

G

odontogenic, ameloblast associated

increases expression

tributyltin results in increased expression of ODAM mRNA

NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,193,302...20,202,517

G

oxoglutarate dehydrogenase

increases expression

tributyltin results in increased expression of OGDH mRNA

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

8-oxoguanine DNA glycosylase

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

olfactory receptor 1049

increases expression

tributyltin results in increased expression of OLR1049 mRNA

NCBI chr 7:6,219,871...6,220,806
Ensembl chr 7:6,207,391...6,220,838

G

one cut homeobox 1

increases expression

tributyltin results in increased expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

olfactory receptor family 10 subfamily A member 48B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR10A48 mRNA

NCBI chr 1:162,793,841...162,794,776
Ensembl chr 1:162,793,610...162,797,017

G

olfactory receptor family 10 subfamily D member 1G

decreases expression

tributyltin results in decreased expression of OR10D1G mRNA

NCBI chr 8:39,143,725...39,144,660
Ensembl chr 8:39,143,725...39,144,660

G

olfactory receptor family 12 subfamily E member 13B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR12E13B mRNA

NCBI chr 3:73,318,605...73,319,540
Ensembl chr 3:73,318,605...73,319,540

G

olfactory receptor family 13 subfamily C member 3C

decreases expression
multiple interactions

tributyltin results in decreased expression of OR13C3C mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of OR13C3 mRNA

NCBI chr 5:67,278,444...67,279,397
Ensembl chr 5:67,277,213...67,282,104

G

olfactory receptor family 13 subfamily F member 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OR13F5 mRNA

NCBI chr 5:67,241,749...67,242,708
Ensembl chr 5:67,241,749...67,242,708

G

olfactory receptor family 13 subfamily M member 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR13M2 mRNA

NCBI chr 4:71,759,747...71,760,682

G

olfactory receptor family 14 subfamily J member 3D

decreases expression

tributyltin results in decreased expression of OR14J3D mRNA

NCBI chr20:872,996...873,910
Ensembl chr20:833,838...846,753

G

olfactory receptor family 1 subfamily F member 19F

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR1F19F mRNA

NCBI chr10:12,227,446...12,232,048
Ensembl chr10:12,231,119...12,232,048

G

olfactory receptor family 1 subfamily O member 2B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR1O2B mRNA

NCBI chr20:1,201,851...1,202,780
Ensembl chr20:1,201,851...1,202,780

G

olfactory receptor family 1 subfamily O member 2C

decreases expression

tributyltin results in decreased expression of OR1O2C mRNA

NCBI chr20:1,073,482...1,074,411
Ensembl chr20:1,073,327...1,085,064

G

olfactory receptor family 2 subfamily T member 26

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR2T26 mRNA

NCBI chr10:33,446,540...33,447,493
Ensembl chr10:33,439,638...33,448,773

G

olfactory receptor family 2 subfamily T member 48D

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR2T48D mRNA

NCBI chr10:42,855,972...42,856,916
Ensembl chr10:42,855,530...42,860,622

G

olfactory receptor family 4 subfamily A member 66C

increases expression

tributyltin results in increased expression of OR4A66C mRNA

NCBI chr 3:74,432,118...74,433,047
Ensembl chr 3:74,432,118...74,433,047

G

olfactory receptor family 4 subfamily F member 14F

decreases expression

tributyltin results in decreased expression of OR4F14F mRNA

NCBI chr 3:98,533,476...98,534,414
Ensembl chr 3:98,532,858...98,537,641

G

olfactory receptor family 51 subfamily A member 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR51A7 mRNA

NCBI chr 1:157,395,779...157,396,717
Ensembl chr 1:157,395,779...157,396,717

G

olfactory receptor family 51 subfamily F member 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OR51F4 mRNA

NCBI chr 1:157,257,231...157,258,175
Ensembl chr 1:157,257,231...157,258,175

G

olfactory receptor family 52 subfamily N member 2F

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OR52N2F mRNA

NCBI chr 1:159,223,286...159,224,242
Ensembl chr 1:159,221,894...159,227,501

G

olfactory receptor family 52 subfamily P member 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR52P1 mRNA

NCBI chr 1:158,889,800...158,890,789
Ensembl chr 1:158,885,881...158,893,038

G

olfactory receptor family 5 subfamily AU member 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5AU1 mRNA

NCBI chr15:24,736,872...24,742,314
Ensembl chr15:24,737,497...24,743,632

G

olfactory receptor family 5 subfamily G member 27B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OR5G27B mRNA

NCBI chr 3:70,670,013...70,670,957
Ensembl chr 3:70,670,013...70,670,957

G

olfactory receptor family 5 subfamily H member 26B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OR5H26B mRNA

NCBI chr11:41,242,182...41,243,111

G

olfactory receptor family 5 subfamily P member 60B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5P60B mRNA

N