tin molecular entity - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tin molecular entity	go back to main search page
Accession:	CHEBI:27008	browse the term
Synonyms:	related_synonym:	tin compounds; tin molecular entities

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Rat (1286 ) Mouse (1242 ) Human (1237 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (1 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (1286)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

ISO

cyhexatin results in increased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

hydroxysteroid (17-beta) dehydrogenase 1

increases activity
increases expression

ISO

cyhexatin results in increased activity of HSD17B1 protein
cyhexatin results in increased expression of HSD17B1 mRNA

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

dibutylstannane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

AKT1 protein affects the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; AKT1 protein affects the reaction [di-n-butyltin results in increased expression of IL6 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

complement C8 gamma chain

multiple interactions

ISO

[dibutyldichlorotin results in increased abundance of di-n-butyltin] affects the reaction [C8G protein binds to triphenyltin]

NCBI chr 3:28,718,648...28,720,232

G

calmodulin 1

multiple interactions

EXP

CALM1 protein inhibits the reaction [di-n-butyltin results in decreased activity of NOS1 protein]; di-n-butyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

caspase 1

multiple interactions

ISO

CASP1 protein affects the reaction [di-n-butyltin affects the secretion of IL1B protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

C-C motif chemokine ligand 5

multiple interactions

ISO

[di-n-butyltin co-treated with LHB protein] results in increased secretion of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

CCAAT/enhancer binding protein alpha

increases expression
multiple interactions

ISO

di-n-butyltin results in increased expression of CEBPA mRNA
T 0070907 inhibits the reaction [di-n-butyltin results in increased expression of CEBPA mRNA]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

cell death-inducing DFFA-like effector c

multiple interactions
increases expression

ISO

T 0070907 inhibits the reaction [di-n-butyltin results in increased expression of CIDEC mRNA]

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806

G

C-X-C motif chemokine ligand 13

multiple interactions

ISO

[di-n-butyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein

NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920

G

cytochrome b-245 beta chain

increases expression

ISO

di-n-butyltin results in increased expression of CYBB mRNA

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases activity
decreases expression

EXP

di-n-butyltin results in decreased activity of CYP11A1 protein
di-n-butyltin results in decreased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

di-n-butyltin analog results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

eukaryotic translation initiation factor 4B

multiple interactions

ISO

di-n-butyltin results in increased expression of and results in increased phosphorylation of EIF4B protein

NCBI chr 7:135,085,259...135,107,054
Ensembl chr 7:135,085,066...135,107,064

G

eukaryotic translation initiation factor 4E

affects phosphorylation

ISO

di-n-butyltin affects the phosphorylation of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

fatty acid binding protein 4

multiple interactions
increases expression

ISO

T 0070907 inhibits the reaction [di-n-butyltin results in increased expression of FABP4 mRNA]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

ISO

di-n-butyltin results in decreased activity of HSD11B2 protein

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression
decreases activity

EXP

di-n-butyltin results in decreased expression of HSD3B1 mRNA
di-n-butyltin results in decreased activity of HSD3B1 protein

NCBI chr 2:188,858,574...188,864,694

G

interleukin 13

multiple interactions

ISO

[di-n-butyltin co-treated with LHB protein] results in increased secretion of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 16

multiple interactions

ISO

[di-n-butyltin co-treated with LHB protein] results in decreased secretion of IL16 protein

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 1 beta

multiple interactions
affects secretion

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [di-n-butyltin affects the secretion of IL1B protein]; CASP1 protein affects the reaction [di-n-butyltin affects the secretion of IL1B protein]; U 0126 affects the reaction [di-n-butyltin affects the secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases secretion
increases expression

ISO

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; AKT1 protein affects the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; AKT1 protein affects the reaction [di-n-butyltin results in increased expression of IL6 protein]; bisindolylmaleimide I inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; bisindolylmaleimide I inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; resveratrol analog inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; resveratrol analog inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]
di-n-butyltin results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

leptin

multiple interactions

ISO

[Dietary Fats co-treated with di-n-butyltin] results in increased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

luteinizing hormone subunit beta

multiple interactions

EXP
ISO

di-n-butyltin inhibits the reaction [LHB protein results in increased chemical synthesis of Androgens]
[di-n-butyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein; [di-n-butyltin co-treated with LHB protein] results in decreased secretion of IL16 protein; [di-n-butyltin co-treated with LHB protein] results in decreased secretion of TNF protein; [di-n-butyltin co-treated with LHB protein] results in increased secretion of CCL5 protein; [di-n-butyltin co-treated with LHB protein] results in increased secretion of CCL8 protein; [di-n-butyltin co-treated with LHB protein] results in increased secretion of IL13 protein; [di-n-butyltin co-treated with LHB protein] results in increased secretion of PDGFAA protein

PMID:33862173 PMID:38630605

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

EXP

di-n-butyltin results in decreased expression of LHCGR mRNA

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061

G

lipoprotein lipase

multiple interactions
increases expression

ISO

T 0070907 inhibits the reaction [di-n-butyltin results in increased expression of LPL mRNA]

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

nitric oxide synthase 1

multiple interactions
decreases activity

EXP

CALM1 protein inhibits the reaction [di-n-butyltin results in decreased activity of NOS1 protein]; di-n-butyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

multiple interactions
increases expression

ISO

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [di-n-butyltin results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

EXP

di-n-butyltin results in decreased expression of NR5A1 mRNA

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

ISO

di-n-butyltin results in increased expression of PPARG mRNA
T 0070907 inhibits the reaction [di-n-butyltin results in increased expression of PPARG mRNA]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase D1

increases phosphorylation

ISO

di-n-butyltin results in increased phosphorylation of PRKD1 protein

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

di-n-butyltin results in decreased expression of and results in decreased phosphorylation of RAF1 protein

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

di-n-butyltin results in increased phosphorylation of and affects the localization of RELA protein; resveratrol analog inhibits the reaction [di-n-butyltin results in increased phosphorylation of and affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ribosomal protein S6

multiple interactions

ISO

di-n-butyltin affects the expression of and results in increased phosphorylation of RPS6 protein

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

retinoid X receptor alpha

increases expression

ISO

di-n-butyltin results in increased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

steroidogenic acute regulatory protein

decreases expression

EXP

di-n-butyltin results in decreased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

tumor necrosis factor

increases expression
multiple interactions

ISO

di-n-butyltin results in increased expression of TNF mRNA
[di-n-butyltin co-treated with LHB protein] results in decreased secretion of TNF protein

PMID:24631921 PMID:38630605

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

diphenylstannane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

complement C8 gamma chain

multiple interactions

ISO

[diphenyltin chloride results in increased abundance of diphenyltin] affects the reaction [C8G protein binds to triphenyltin]

NCBI chr 3:28,718,648...28,720,232

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

ISO

diphenyltin results in decreased activity of HSD11B2 protein

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

increases expression

ISO

phentin acetate results in increased expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

folate hydrolase 1

increases expression

ISO

phentin acetate results in increased expression of FOLH1 mRNA

NCBI chr 1:149,828,286...149,914,313
Ensembl chr 1:149,840,760...149,914,035

G

kallikrein 1-related peptidase C10

decreases expression

ISO

phentin acetate results in decreased expression of KLK3 mRNA

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

NK3 homeobox 1

decreases expression

ISO

phentin acetate results in decreased expression of NKX3-1 mRNA

NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251

G

prostate transmembrane protein, androgen induced 1

decreases expression

ISO

phentin acetate results in decreased expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649

G

tumor protein p53

affects activity

ISO

phentin acetate affects the activity of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

fentin chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

ISO

[triphenyltin chloride results in increased abundance of triphenyltin] which results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily C member 3

increases expression

EXP

triphenyltin chloride results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP-binding cassette, subfamily G (WHITE), member 3-like 4

increases expression

EXP

triphenyltin chloride results in increased expression of ABCG3L4 mRNA

NCBI chr14:4,545,206...4,590,223
Ensembl chr14:4,849,938...4,890,081

G

acyl-CoA thioesterase 5

decreases expression

EXP

triphenyltin chloride results in decreased expression of ACOT5 mRNA

NCBI chr 6:109,433,062...109,439,846
Ensembl chr 6:109,453,391...109,461,035
Ensembl chr 6:109,453,391...109,461,035

G

acyl-CoA synthetase long-chain family member 1

increases expression

EXP

triphenyltin chloride results in increased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

acyl-CoA synthetase medium-chain family member 2

increases expression

EXP

triphenyltin chloride results in increased expression of ACSM2 mRNA

NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453

G

acyl-CoA synthetase medium-chain family member 5

increases expression

EXP

triphenyltin chloride results in increased expression of ACSM5 mRNA

NCBI chr 1:173,870,873...173,896,838
Ensembl chr 1:183,294,105...183,329,925

G

adiponectin, C1Q and collagen domain containing

multiple interactions
increases expression

ISO

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] affects the expression of ADIPOQ protein; triphenyltin chloride inhibits the reaction [Dexamethasone results in increased expression of ADIPOQ protein]; triphenyltin chloride inhibits the reaction [Rosiglitazone results in increased expression of ADIPOQ protein]
triphenyltin chloride results in increased expression of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

aldehyde dehydrogenase 1 family, member A1

increases expression

EXP

triphenyltin chloride results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase family 1, subfamily A7

increases expression

EXP

triphenyltin chloride results in increased expression of ALDH1A7 mRNA

NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523

G

aldehyde dehydrogenase 1 family, member L2

decreases expression

EXP

triphenyltin chloride results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398

G

annexin A5

decreases expression
multiple interactions

ISO

triphenyltin chloride results in decreased expression of ANXA5 protein
Tretinoin promotes the reaction [triphenyltin chloride results in decreased expression of ANXA5 protein]

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

APC down-regulated 1

increases expression

EXP

triphenyltin chloride results in increased expression of APCDD1 mRNA

NCBI chr18:58,655,696...58,686,359
Ensembl chr18:58,655,919...58,686,356

G

androgen receptor

multiple interactions

ISO

triphenyltin chloride inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

Rho guanine nucleotide exchange factor 19

decreases expression

EXP

triphenyltin chloride results in decreased expression of ARHGEF19 mRNA

NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:158,818,932...158,837,196

G

arrestin domain containing 3

increases expression

EXP

triphenyltin chloride results in increased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875

G

ATPase phospholipid transporting 8B3

decreases expression

EXP

triphenyltin chloride results in decreased expression of ATP8B3 mRNA

NCBI chr 7:9,175,544...9,195,449
Ensembl chr 7:9,826,275...9,846,195

G

betaine-homocysteine S-methyltransferase

decreases expression

EXP

triphenyltin chloride results in decreased expression of BHMT mRNA

NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:26,594,854...26,614,715

G

BTG anti-proliferation factor 2

increases expression

EXP

triphenyltin chloride results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

ceramide synthase 6

increases expression

EXP

triphenyltin chloride results in increased expression of CERS6 mRNA

NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544

G

carboxylesterase 2C

increases expression

EXP

triphenyltin chloride results in increased expression of CES2C mRNA

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:270,374,913...270,384,801

G

claudin 1

decreases expression

EXP

triphenyltin chloride results in decreased expression of CLDN1 mRNA

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

CREB3 regulatory factor

increases expression

EXP

triphenyltin chloride results in increased expression of CREBRF mRNA

NCBI chr10:16,903,607...16,967,450
Ensembl chr10:16,903,547...16,966,430

G

carnitine O-octanoyltransferase

decreases expression

EXP

triphenyltin chloride results in decreased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

ISO

triphenyltin chloride results in increased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6, pseudogene 2

increases expression

EXP

triphenyltin chloride results in increased expression of CYP2C6-PS2 mRNA

NCBI chr 1:248,272,290...248,328,853

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

EXP

triphenyltin chloride results in increased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

dual specificity phosphatase 6

increases expression

EXP

triphenyltin chloride results in increased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

early growth response 1

increases expression

EXP

triphenyltin chloride results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

EXP

triphenyltin chloride results in increased expression of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

ELOVL fatty acid elongase 5

decreases expression
increases expression

EXP

triphenyltin chloride results in decreased expression of ELOVL5 mRNA
triphenyltin chloride results in increased expression of ELOVL5 mRNA

NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:87,671,159...87,737,616

G

endoplasmic reticulum to nucleus signaling 1

increases expression

EXP

triphenyltin chloride results in increased expression of ERN1 protein

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

estrogen receptor 2

multiple interactions

ISO

triphenyltin chloride binds to and results in decreased activity of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

fatty acid binding protein 4

multiple interactions
increases expression

ISO

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of FABP4 protein; triphenyltin chloride affects the reaction [tributyltin results in increased expression of FABP4 protein]; triphenyltin chloride promotes the reaction [Dexamethasone results in increased expression of FABP4 protein]; triphenyltin chloride promotes the reaction [Rosiglitazone results in increased expression of FABP4 protein]
triphenyltin chloride results in increased expression of FABP4 protein

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

flavin containing dimethylaniline monoxygenase 1

increases expression

EXP

triphenyltin chloride results in increased expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

forkhead box A2

increases expression

EXP

triphenyltin chloride results in increased expression of FOXA2 mRNA

NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:155,923,307...155,928,757

G

growth arrest and DNA-damage-inducible, beta

increases expression

EXP

triphenyltin chloride results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

ISO

triphenyltin chloride results in decreased expression of GAPDH protein
triphenyltin chloride promotes the reaction [Tretinoin results in decreased expression of GAPDH protein]

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

glucosaminyl (N-acetyl) transferase 2

increases expression

EXP

triphenyltin chloride results in increased expression of GCNT2 mRNA

NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989

G

glycine decarboxylase

decreases expression

EXP

triphenyltin chloride results in decreased expression of GLDC mRNA

NCBI chr 1:237,296,753...237,375,620
Ensembl chr 1:237,296,753...237,375,604

G

glycosyltransferase 1 domain containing 1

increases expression

EXP

triphenyltin chloride results in increased expression of GLT1D1 mRNA

NCBI chr12:34,611,942...34,685,591
Ensembl chr12:34,612,643...34,685,468

G

glutamate-ammonia ligase

increases expression

EXP

triphenyltin chloride results in increased expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

EXP

triphenyltin chloride results in decreased expression of GPAM mRNA

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

glutathione S-transferase, theta 3

increases expression

EXP

triphenyltin chloride results in increased expression of GSTT3 mRNA

NCBI chr20:12,873,618...12,881,974
Ensembl chr20:12,874,374...12,881,973

G

H1.2 linker histone, cluster member

increases expression

EXP

triphenyltin chloride results in increased expression of H1F2 mRNA

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

H3 histone, family 3C

increases expression

EXP

triphenyltin chloride results in increased expression of H3F3C mRNA

NCBI chr 7:86,501,085...86,502,124
Ensembl chr 7:88,378,607...88,392,406

G

histone acetyltransferase 1

increases activity

EXP

triphenyltin chloride results in increased activity of HAT1 protein

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

EXP

triphenyltin chloride results in increased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

EXP

triphenyltin chloride results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases expression

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein]; Cycloheximide promotes the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA]; Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [triphenyltin chloride results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA]; triphenyltin chloride results in increased expression of and results in increased activity of HSD11B2 protein

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 1

increases expression
increases activity

ISO

triphenyltin chloride results in increased expression of HSD17B1 mRNA
triphenyltin chloride results in increased activity of HSD17B1 protein

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

G

heat shock protein family B (small) member 1

increases expression

EXP

triphenyltin chloride results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

immediate early response 2

increases expression

EXP

triphenyltin chloride results in increased expression of IER2 mRNA

NCBI chr19:40,399,373...40,400,897
Ensembl chr19:40,398,160...40,402,708

G

insulin-like growth factor binding protein 1

increases expression

EXP

triphenyltin chloride results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

increases expression

EXP

triphenyltin chloride results in increased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

interleukin 1 beta

multiple interactions

ISO

Lipopolysaccharides promotes the reaction [triphenyltin chloride results in increased expression of IL1B mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

Lipopolysaccharides promotes the reaction [triphenyltin chloride results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibin subunit beta C

decreases expression

EXP

triphenyltin chloride results in decreased expression of INHBC mRNA

NCBI chr 7:65,069,450...65,082,919
Ensembl chr 7:65,069,451...65,082,919

G

inhibin subunit beta E

decreases expression

EXP

triphenyltin chloride results in decreased expression of INHBE mRNA

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

triphenyltin chloride results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium inwardly-rectifying channel, subfamily J, member 15

increases expression

EXP

triphenyltin chloride results in increased expression of KCNJ15 mRNA

NCBI chr11:48,046,953...48,091,285
Ensembl chr11:48,035,655...48,092,457

G

killer cell lectin like receptor G1

decreases expression

EXP

triphenyltin chloride results in decreased expression of KLRG1 mRNA

NCBI chr 4:157,127,571...157,139,372
Ensembl chr 4:157,127,571...157,139,372

G

lactate dehydrogenase A

decreases expression

EXP

triphenyltin chloride results in decreased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

liver enriched antimicrobial peptide 2

decreases expression

EXP

triphenyltin chloride results in decreased expression of LEAP2 mRNA

NCBI chr10:38,081,001...38,082,073
Ensembl chr10:38,081,001...38,082,073

G

leptin receptor

increases expression

EXP

triphenyltin chloride results in increased expression of LEPR mRNA

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

lymphocyte antigen 75

increases expression

EXP

triphenyltin chloride results in increased expression of LY75 mRNA

NCBI chr 3:65,173,395...65,260,878
Ensembl chr 3:65,173,395...65,260,878

G

mesenchyme homeobox 2

increases expression

EXP

triphenyltin chloride results in increased expression of MEOX2 mRNA

NCBI chr 6:59,584,025...59,644,722
Ensembl chr 6:59,583,785...59,644,700

G

matrix metallopeptidase 8

increases expression

EXP

triphenyltin chloride results in increased expression of MMP8 mRNA

NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729

G

metallothionein 1A

increases expression

EXP

triphenyltin chloride results in increased expression of MT1 mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

increases expression

EXP

triphenyltin chloride results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

methylenetetrahydrofolate reductase

decreases expression

EXP

triphenyltin chloride results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

MYB proto-oncogene like 1

decreases expression

EXP

triphenyltin chloride results in decreased expression of MYBL1 mRNA

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

neuroepithelial cell transforming 1

increases expression

EXP

triphenyltin chloride results in increased expression of NET1 mRNA

NCBI chr17:71,251,145...71,280,345
Ensembl chr17:71,251,149...71,289,270

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions
decreases expression

ISO

Tretinoin promotes the reaction [triphenyltin chloride results in decreased expression of NME2 protein]

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

nocturnin

decreases expression

EXP

triphenyltin chloride results in decreased expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282

G

nephronectin

decreases expression

EXP

triphenyltin chloride results in decreased expression of NPNT mRNA

NCBI chr 2:221,391,151...221,459,527
Ensembl chr 2:224,065,191...224,133,435

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

triphenyltin chloride binds to and results in decreased activity of NR1I2 protein
triphenyltin chloride binds to and results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

opioid growth factor receptor-like 1

increases expression

EXP

triphenyltin chloride results in increased expression of OGFRL1 mRNA

NCBI chr 9:33,320,501...33,338,742
Ensembl chr 9:33,324,392...33,339,237

G

oxidative stress induced growth inhibitor 1

increases expression

EXP

triphenyltin chloride results in increased expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

phospholipase A2, group XV

increases expression

EXP

triphenyltin chloride results in increased expression of PLA2G15 mRNA

NCBI chr19:50,960,568...50,977,948
Ensembl chr19:50,960,598...50,977,946

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP

triphenyltin chloride results in increased expression of and affects the localization of PPARA protein

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression
increases activity

ISO
EXP

diphenyltin chloride inhibits the reaction [triphenyltin chloride binds to PPARG protein]; tetrabutyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]; tributyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]; triphenyltin chloride binds to and results in increased activity of PPARG protein; triphenyltin chloride inhibits the reaction [Rosiglitazone binds to PPARG protein]
triphenyltin chloride results in increased expression of and affects the localization of PPARG protein
triphenyltin chloride results in increased expression of PPARG protein
[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of PPARG protein; triphenyltin chloride binds to and results in increased activity of PPARG protein; triphenyltin chloride inhibits the reaction [Dexamethasone results in increased expression of PPARG protein]; triphenyltin chloride inhibits the reaction [Rosiglitazone results in increased expression of PPARG protein]
triphenyltin chloride results in increased activity of PPARG protein

PMID:19497422 PMID:26172262 PMID:33049310 PMID:37142754 PMID:37156404

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

regenerating family member 4

decreases expression

EXP

triphenyltin chloride results in decreased expression of REG4 mRNA

NCBI chr 2:188,507,684...188,521,990
Ensembl chr 2:188,507,684...188,521,990

G

regulator of G-protein signaling 16

increases expression

EXP

triphenyltin chloride results in increased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

retinoid X receptor alpha

multiple interactions
increases expression

ISO
EXP

RXRA protein affects the reaction [triphenyltin chloride results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA]; triphenyltin chloride inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyltin chloride inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]
triphenyltin chloride results in increased expression of RXRA protein

PMID:15941851 PMID:31927052 PMID:37156404

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

sphingosine-1-phosphate receptor 1

decreases expression

EXP

triphenyltin chloride results in decreased expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689

G

stearoyl-CoA desaturase

decreases expression

EXP

triphenyltin chloride results in decreased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

serpin family A member 7

increases expression

EXP

triphenyltin chloride results in increased expression of SERPINA7 mRNA

NCBI chr X:107,452,044...107,510,958
Ensembl chr X:107,452,044...107,457,681

G

sigma non-opioid intracellular receptor 1

decreases expression

EXP

triphenyltin chloride results in decreased expression of SIGMAR1 mRNA

NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855

G

solute carrier family 16 member 10

increases expression

EXP

triphenyltin chloride results in increased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 1 member 2

increases expression

EXP

triphenyltin chloride results in increased expression of SLC1A2 mRNA

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 34 member 2

decreases expression

EXP

triphenyltin chloride results in decreased expression of SLC34A2 mRNA

NCBI chr14:62,123,313...62,153,020
Ensembl chr14:62,123,316...62,143,360

G

secretory leukocyte peptidase inhibitor

increases expression

EXP

triphenyltin chloride results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

SPARC like 1

increases expression

EXP

triphenyltin chloride results in increased expression of SPARCL1 mRNA

NCBI chr14:5,937,484...5,968,532
Ensembl chr14:5,914,535...5,969,120

G

serine peptidase inhibitor, Kazal type 1

increases expression

EXP

triphenyltin chloride results in increased expression of SPINK1 mRNA

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

ISO
EXP

[triphenyltin chloride results in increased abundance of triphenyltin] which results in increased expression of SREBF1 mRNA
triphenyltin chloride results in decreased expression of SREBF1 mRNA

PMID:35998708 PMID:37156404

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

somatostatin receptor 3

decreases expression

EXP

triphenyltin chloride results in decreased expression of SSTR3 mRNA

NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:111,972,811...111,997,368

G

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

decreases expression

EXP

triphenyltin chloride results in decreased expression of ST6GALNAC4 mRNA

NCBI chr 3:36,269,834...36,282,971
Ensembl chr 3:36,269,878...36,282,971

G

thyroid hormone receptor beta

multiple interactions

ISO

triphenyltin chloride binds to and results in increased activity of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

tumor necrosis factor

increases secretion

ISO

triphenyltin chloride results in increased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

torsin family 3, member A

decreases expression

EXP

triphenyltin chloride results in decreased expression of TOR3A mRNA

NCBI chr13:71,324,073...71,348,625
Ensembl chr13:71,324,076...71,348,624

G

tribbles pseudokinase 1

increases expression

EXP

triphenyltin chloride results in increased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

transthyretin

decreases expression

EXP

triphenyltin chloride results in decreased expression of TTR mRNA

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

thioredoxin interacting protein

increases expression

EXP

triphenyltin chloride results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

beta-ureidopropionase 1

decreases expression

EXP

triphenyltin chloride results in decreased expression of UPB1 mRNA

NCBI chr20:13,216,693...13,243,016
Ensembl chr20:13,216,691...13,277,562

G

uridine phosphorylase 2

increases expression

EXP

triphenyltin chloride results in increased expression of UPP2 mRNA

NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:63,681,826...63,726,191

G

vimentin

decreases expression
multiple interactions

ISO

triphenyltin chloride results in decreased expression of VIM protein
[Tretinoin co-treated with triphenyltin chloride] results in decreased expression of VIM mRNA; Tretinoin promotes the reaction [triphenyltin chloride results in decreased expression of VIM protein]

PMID:30806631 PMID:31634547

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vexin

decreases expression

EXP

triphenyltin chloride results in decreased expression of VXN mRNA

NCBI chr 5:9,659,213...9,684,684
Ensembl chr 5:14,442,040...14,467,500

G

WAP four-disulfide core domain 2

increases expression

EXP

triphenyltin chloride results in increased expression of WFDC2 mRNA

NCBI chr 3:173,706,091...173,735,055
Ensembl chr 3:173,706,460...173,712,161

G

X-box binding protein 1

increases expression

EXP

triphenyltin chloride results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

Y box binding protein 2

decreases expression

EXP

triphenyltin chloride results in decreased expression of YBX2 mRNA

NCBI chr10:55,158,420...55,164,077
Ensembl chr10:55,158,420...55,164,077

G

zinc finger protein 622

increases expression

EXP

triphenyltin chloride results in increased expression of ZFP622 mRNA

NCBI chr 2:78,205,655...78,224,888
Ensembl chr 2:78,066,031...78,225,356

fentin hydroxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma-carboxyglutamate protein

multiple interactions

ISO

triphenyltin hydroxide inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO

[triphenyltin hydroxide binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein
triphenyltin hydroxide results in increased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

fatty acid binding protein 4

multiple interactions

ISO

triphenyltin hydroxide promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of FABP4 mRNA]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

hydroxysteroid (17-beta) dehydrogenase 1

increases activity
increases expression

ISO

triphenyltin hydroxide results in increased activity of HSD17B1 protein
triphenyltin hydroxide results in increased expression of HSD17B1 mRNA

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

G

insulin 2

multiple interactions

ISO

triphenyltin hydroxide inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]; triphenyltin hydroxide inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]; triphenyltin hydroxide promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of FABP4 mRNA]; triphenyltin hydroxide promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PLIN1 mRNA]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

perilipin 1

multiple interactions

ISO

triphenyltin hydroxide promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PLIN1 mRNA]

NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

triphenyltin hydroxide results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

retinoid X receptor alpha

multiple interactions

ISO

[triphenyltin hydroxide binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; Alitretinoin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; tributyltin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; triphenyltin chloride inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; triphenyltin hydroxide binds to and affects the activity of RXRA protein; triphenyltin hydroxide inhibits the reaction [Alitretinoin binds to RXRA protein]

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

retinoid X receptor beta

multiple interactions

ISO

triphenyltin hydroxide binds to and affects the activity of RXRB protein

NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359

G

retinoid X receptor gamma

multiple interactions

ISO

triphenyltin hydroxide binds to and affects the activity of RXRG protein

NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095

G

Sp7 transcription factor

multiple interactions

ISO

triphenyltin hydroxide inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

transforming growth factor, beta 1

decreases activity

ISO

triphenyltin hydroxide results in decreased activity of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

thyroid hormone receptor beta

affects binding

ISO

triphenyltin hydroxide binds to THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

tumor necrosis factor

multiple interactions

ISO

triphenyltin hydroxide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

microRNA 196b

multiple interactions

ISO

[Air Pollutants, Occupational results in increased abundance of Tin] which results in increased expression of MIR196B mRNA

NCBI chr 4:82,661,101...82,661,185

G

superoxide dismutase 1

multiple interactions

ISO

[[Industrial Waste results in increased abundance of Trace Elements] which results in increased abundance of Tin] which affects the expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

TAR DNA binding protein

affects localization

ISO

Tin affects the localization of TARDBP protein

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

TSC22 domain family, member 3

multiple interactions

ISO

[stannous chloride results in increased abundance of Tin] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

tin(II) chloride (anhydrous)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

multiple interactions

EXP

[stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

EXP

[stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

dentin matrix acidic phosphoprotein 1

increases expression

ISO

stannous chloride results in increased expression of DMP1 mRNA

NCBI chr14:5,833,111...5,867,154
Ensembl chr14:5,833,111...5,843,993

G

estrogen receptor 1

multiple interactions
increases activity
affects response to substance
decreases expression

ISO

stannous chloride inhibits the reaction [Estradiol binds to ESR1 protein]
stannous chloride results in increased activity of ESR1 protein
ESR1 protein affects the susceptibility to stannous chloride
stannous chloride results in decreased expression of ESR1 mRNA; stannous chloride results in decreased expression of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

coagulation factor III, tissue factor

increases expression

ISO

stannous chloride results in increased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

stannous chloride results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

heme oxygenase 1

multiple interactions
increases activity

EXP

[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2 protein; [stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2L1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

orosomucoid 1

increases expression

ISO

stannous chloride results in increased expression of ORM1 mRNA

NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667

G

phosphate regulating endopeptidase X-linked

increases expression

ISO

stannous chloride results in increased expression of PHEX mRNA

NCBI chr X:41,422,561...41,671,226
Ensembl chr X:41,426,101...41,671,226

G

scavenger receptor class B, member 1

increases expression

ISO

stannous chloride results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

solute carrier family 2 member 1

increases expression

ISO

stannous chloride results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

transferrin receptor

increases expression

ISO

stannous chloride results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

TSC22 domain family, member 3

multiple interactions

ISO

[stannous chloride results in increased abundance of Tin] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

vascular endothelial growth factor A

increases expression

ISO

stannous chloride results in increased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

tributylstannane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

decreases expression

ISO

tributyltin results in decreased expression of A1BG mRNA

NCBI chr 7:94,383,333...94,387,922
Ensembl chr 7:94,383,333...94,387,496

G

AADACL2 family member 2

increases expression

EXP

tributyltin results in increased expression of AADACL2FM2 mRNA

NCBI chr 2:146,033,047...146,061,074
Ensembl chr 2:146,033,107...146,060,242

G

aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of AASDHPPT mRNA

NCBI chr 8:9,731,592...9,748,934
Ensembl chr 8:9,738,172...9,748,953

G

ATP binding cassette subfamily A member 1

increases expression
multiple interactions

ISO

tributyltin results in increased expression of ABCA1; tributyltin results in increased expression of ABCA1 mRNA
diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]
[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA; [tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein; diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]; UVI 3003 inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]

PMID:21622945 PMID:23824090 PMID:24356939 PMID:25932594 PMID:31006824

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily B member 1A

decreases expression
increases expression

EXP
ISO

tributyltin results in decreased expression of ABCB1 protein
tributyltin results in increased expression of ABCB1A mRNA

PMID:26079211 PMID:31939706

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily G member 1

increases expression

ISO

tributyltin results in increased expression of ABCG1 mRNA

PMID:23824090 PMID:24356939

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

acetyl-CoA acyltransferase 2

increases expression

ISO

tributyltin results in increased expression of ACAA2 mRNA

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

acetyl-CoA carboxylase alpha

increases expression

ISO

tributyltin results in increased expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase, long chain

increases expression

ISO

tributyltin results in increased expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164

G

acyl-CoA dehydrogenase medium chain

increases expression

ISO

tributyltin results in increased expression of ACADM mRNA

PMID:23428407 PMID:24848799

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acyl-CoA dehydrogenase, very long chain

increases expression

ISO

tributyltin results in increased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ACAP2 mRNA

NCBI chr11:83,043,442...83,159,105
Ensembl chr11:83,043,511...83,159,107

G

acetyl-CoA acetyltransferase 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ACAT1 mRNA

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042

G

acetyl-CoA acetyltransferase 2-like 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ACAT2L1 mRNA

NCBI chr 1:50,341,596...50,376,961
Ensembl chr 1:50,359,869...50,376,959

G

angiotensin I converting enzyme

increases expression

ISO

tributyltin results in increased expression of ACE mRNA

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

angiotensin converting enzyme 2

increases expression

ISO

tributyltin results in increased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

aconitase 2

increases expression

ISO

tributyltin results in increased expression of ACO2 mRNA

PMID:23428407 PMID:24848799

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 3

increases expression

ISO

tributyltin results in increased expression of ACOT3 mRNA

NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:109,413,534...109,421,427
Ensembl chr 6:109,413,534...109,421,427

G

acyl-CoA oxidase 1

increases expression

ISO

tributyltin results in increased expression of ACOX1 mRNA

PMID:23322813 PMID:23428407

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acyl-CoA oxidase-like

increases expression

EXP

tributyltin results in increased expression of ACOXL mRNA

NCBI chr 3:135,514,340...135,820,291
Ensembl chr 3:135,514,275...135,820,291

G

acyl-CoA synthetase long-chain family member 1

increases expression

ISO

tributyltin results in increased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

acyl-CoA synthetase long-chain family member 3

increases expression

ISO

tributyltin results in increased expression of ACSL3 mRNA

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097

G

acyl-CoA synthetase short-chain family member 1

increases expression

ISO

tributyltin results in increased expression of ACSS1 mRNA

NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748

G

actin alpha 2, smooth muscle

increases expression

EXP

tributyltin results in increased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

actinin, alpha 1

increases expression

ISO

tributyltin results in increased expression of ACTN1 mRNA

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172

G

adenosine deaminase

increases expression

ISO

tributyltin results in increased expression of ADA mRNA

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293

G

ADAM metallopeptidase domain 9

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ADAM9 mRNA

NCBI chr16:73,725,186...73,804,284
Ensembl chr16:73,725,114...73,804,646

G

ADAM metallopeptidase with thrombospondin type 1 motif, 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ADAMTS2 mRNA

NCBI chr10:35,422,030...35,627,483
Ensembl chr10:35,422,030...35,627,483

G

ArfGAP with dual PH domains 1

increases expression

ISO

tributyltin results in increased expression of ADAP1 mRNA

NCBI chr12:20,438,091...20,489,961
Ensembl chr12:20,438,063...20,495,020

G

adenosine deaminase, RNA-specific, B1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ADARB1 mRNA

NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,164...11,350,415

G

adenylate cyclase 1

decreases expression

ISO

tributyltin results in decreased expression of ADCY1 mRNA

NCBI chr14:86,125,119...86,234,459
Ensembl chr14:86,124,850...86,261,075

G

adenylate cyclase 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ADCY2 mRNA; [bisphenol A co-treated with tributyltin] results in increased expression of ADCY2 protein

NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645

G

ADCYAP receptor type I

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ADCYAP1R1 mRNA

NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:85,924,100...85,972,973

G

adiponectin, C1Q and collagen domain containing

multiple interactions
decreases expression
decreases secretion
affects expression
increases expression

ISO
EXP

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] affects the expression of ADIPOQ protein; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]
tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]; tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
tributyltin results in decreased expression of ADIPOQ protein
tributyltin results in decreased secretion of ADIPOQ protein
tributyltin affects the expression of ADIPOQ protein
tributyltin results in increased expression of ADIPOQ mRNA; tributyltin results in increased expression of ADIPOQ protein

PMID:22197818 PMID:23428407 PMID:28161095 PMID:28397090 PMID:29675927 More...

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adiponectin receptor 2

increases expression

ISO

tributyltin results in increased expression of ADIPOR2 mRNA

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666

G

adrenoceptor beta 2

decreases expression

ISO

tributyltin results in decreased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

alpha-fetoprotein

increases expression

ISO

tributyltin results in increased expression of AFP mRNA

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

1-acylglycerol-3-phosphate O-acyltransferase 2

increases expression

ISO

tributyltin results in increased expression of AGPAT2 mRNA

NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:29,814,924...29,826,581

G

1-acylglycerol-3-phosphate O-acyltransferase 3

increases expression

ISO

tributyltin results in increased expression of AGPAT3 mRNA

NCBI chr20:10,330,650...10,415,026
Ensembl chr20:10,394,465...10,410,632

G

angiotensinogen

increases expression
decreases expression

ISO
EXP

tributyltin results in increased expression of AGT mRNA
tributyltin results in decreased expression of AGT protein modified form

PMID:23428407 PMID:30172001

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

increases expression

EXP

tributyltin results in increased expression of AGTR1A protein

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

angiotensin II receptor, type 2

decreases expression

ISO

tributyltin results in decreased expression of AGTR2 protein

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

AHNAK nucleoprotein

increases expression

EXP

tributyltin results in increased expression of AHNAK mRNA

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

aryl hydrocarbon receptor

decreases expression

ISO

tributyltin results in decreased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aryl-hydrocarbon receptor repressor

multiple interactions
decreases expression

ISO

tributyltin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]
tributyltin results in decreased expression of AHRR mRNA

NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866

G

allograft inflammatory factor 1

multiple interactions
decreases expression

EXP

Phycocyanin inhibits the reaction [tributyltin results in decreased expression of AIF1 protein]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

AIF family member 2

increases expression

ISO

tributyltin results in increased expression of AIFM2 mRNA

NCBI chr20:30,195,781...30,222,014
Ensembl chr20:30,193,829...30,220,957

G

aldo-keto reductase family 1 member B1

increases expression

ISO

tributyltin results in increased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1, member B7

increases expression

ISO

tributyltin results in increased expression of AKR1B7 mRNA

NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909

G

AKT serine/threonine kinase 1

increases expression
increases phosphorylation

EXP
ISO

tributyltin results in increased expression of AKT1 protein
tributyltin results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of AKT3 mRNA

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020

G

5'-aminolevulinate synthase 1

increases expression

ISO

tributyltin results in increased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

aldehyde dehydrogenase 18 family, member A1

increases expression

ISO

tributyltin results in increased expression of ALDH18A1 mRNA

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:249,325,082...249,357,383

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ALDH1A1 mRNA; [bisphenol A co-treated with tributyltin] results in decreased expression of ALDH1A1 protein

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 8 family, member A1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:18,003,507...18,022,952
Ensembl chr 1:18,003,514...18,023,883

G

ALG8, alpha-1,3-glucosyltransferase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ALG8 mRNA

NCBI chr 1:161,095,570...161,115,533
Ensembl chr 1:161,095,412...161,115,527

G

arachidonate 5-lipoxygenase activating protein

multiple interactions
decreases expression

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ALOX5AP mRNA
tributyltin results in decreased expression of ALOX5AP mRNA

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

alkaline phosphatase, biomineralization associated

multiple interactions
decreases expression

ISO

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]
tributyltin results in decreased expression of ALPL mRNA; tributyltin results in decreased expression of ALPL protein

PMID:22749964 PMID:23322813 PMID:25777084

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

angiogenin

decreases expression

ISO

tributyltin results in decreased expression of ANG mRNA

NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106

G

angiopoietin 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ANGPT2 mRNA

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:77,790,563...77,841,239

G

angiopoietin-like 4

increases expression

EXP
ISO

tributyltin results in increased expression of ANGPTL4 mRNA

PMID:21622945 PMID:21683754 PMID:23428407

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

ankyrin repeat domain 27

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ANKRD27 mRNA

NCBI chr 1:97,387,997...97,440,501
Ensembl chr 1:97,388,099...97,440,501

G

ankyrin repeat domain 37

increases expression

EXP

tributyltin results in increased expression of ANKRD37 mRNA

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545

G

annexin A4

increases expression

EXP

tributyltin results in increased expression of ANXA4 mRNA

NCBI chr 4:120,741,750...120,798,534
Ensembl chr 4:120,741,750...120,798,513

G

annexin A5

multiple interactions
decreases expression

ISO

Tretinoin promotes the reaction [tributyltin results in decreased expression of ANXA5 protein]

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

adaptor related protein complex 1 subunit mu 2

increases expression

ISO

tributyltin results in increased expression of AP1M2 mRNA

NCBI chr 8:28,114,748...28,132,767
Ensembl chr 8:28,114,748...28,132,642

G

adaptor related protein complex 3 subunit sigma 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of AP3S2 mRNA

NCBI chr 1:143,228,131...143,268,573
Ensembl chr 1:143,228,135...143,268,573

G

apolipoprotein C1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of APOC1 mRNA

NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:88,474,663...88,478,155

G

apolipoprotein E

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

apolipoprotein L2

decreases expression
multiple interactions

EXP

tributyltin results in decreased expression of APOL2 mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of APOL2 mRNA

NCBI chr 7:111,211,944...111,219,209
Ensembl chr 7:111,211,893...111,217,223

G

androgen receptor

multiple interactions

ISO

tributyltin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

Rho GTPase activating protein 36

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ARHGAP36 mRNA

NCBI chr X:133,635,996...133,664,995
Ensembl chr X:133,635,973...133,664,888

G

Rho guanine nucleotide exchange factor 16

increases expression

ISO

tributyltin results in increased expression of ARHGEF16 mRNA

NCBI chr 5:170,126,573...170,148,624
Ensembl chr 5:170,126,575...170,148,624

G

ADP-ribosyltransferase 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ART3 mRNA

NCBI chr14:15,921,540...16,003,764
Ensembl chr14:15,921,395...15,949,806

G

ankyrin repeat and SOCS box-containing 10

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ASB10 mRNA

NCBI chr 4:11,522,531...11,531,946
Ensembl chr 4:11,522,887...11,531,505

G

achaete-scute family bHLH transcription factor 1

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in increased expression of ASCL1 mRNA

NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:23,790,360...23,798,231

G

achaete-scute family bHLH transcription factor 2

affects expression

ISO

tributyltin affects the expression of ASCL2 mRNA

NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856

G

asialoglycoprotein receptor 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ASGR1 mRNA

NCBI chr10:55,274,299...55,278,323
Ensembl chr10:55,274,706...55,278,322

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

tributyltin results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

aspartoacylase

increases expression

ISO

tributyltin results in increased expression of ASPA mRNA

NCBI chr10:58,390,204...58,443,790
Ensembl chr10:58,379,410...58,443,769

G

asporin

increases expression

EXP

tributyltin results in increased expression of ASPN mRNA

NCBI chr17:15,286,338...15,310,567
Ensembl chr17:15,287,065...15,310,632

G

astacin like metalloendopeptidase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ASTL mRNA

NCBI chr 3:135,016,444...135,032,177
Ensembl chr 3:135,016,444...135,032,177

G

ATPase family, AAA domain containing 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ATAD5 mRNA

NCBI chr10:65,568,569...65,616,379
Ensembl chr10:65,568,591...65,616,376

G

activating transcription factor 2

increases phosphorylation

ISO

tributyltin results in increased phosphorylation of ATF2 protein

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

activating transcription factor 3

increases expression

EXP

tributyltin results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 6

increases cleavage

ISO

tributyltin results in increased cleavage of ATF6 protein

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

ATM serine/threonine kinase

increases phosphorylation
multiple interactions

ISO

tributyltin results in increased phosphorylation of ATM protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of ATM protein]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase phospholipid transporting 11A

decreases expression

ISO

tributyltin results in decreased expression of ATP11A mRNA

NCBI chr16:83,359,884...83,469,807
Ensembl chr16:83,359,884...83,469,767

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

ISO

tributyltin results in decreased expression of ATP2A2 protein

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of B3GALNT1 mRNA

NCBI chr 2:156,157,234...156,187,037
Ensembl chr 2:156,156,265...156,188,404

G

Beta-1,3-galactosyltransferase 1

decreases expression

ISO

tributyltin results in decreased expression of B3GALT1 mRNA

NCBI chr 3:72,661,410...73,234,447
Ensembl chr 3:72,660,801...73,235,276

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

increases expression

ISO

tributyltin results in increased expression of B3GNT3 mRNA

NCBI chr16:18,434,114...18,444,851
Ensembl chr16:18,435,378...18,444,738

G

BCL2-associated agonist of cell death

multiple interactions

ISO

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BAD protein modified form]

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BAG cochaperone 3

affects expression

ISO

tributyltin affects the expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BAR/IMD domain containing adaptor protein 2 like 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BAIAP2L1 mRNA

NCBI chr12:15,364,090...15,453,602
Ensembl chr12:15,364,109...15,453,605

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

ISO
EXP

tributyltin affects the expression of BAX protein
PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of BAX protein]
Phycocyanin inhibits the reaction [tributyltin results in increased expression of BAX protein]

PMID:22223438 PMID:23743147 PMID:25895139 PMID:26079211 PMID:28707438

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bromodomain adjacent to zinc finger domain, 2A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BAZ2A mRNA

NCBI chr 7:1,107,377...1,145,507
Ensembl chr 7:1,107,796...1,145,507

G

BBSome interacting protein 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BBIP1 mRNA

NCBI chr 1:262,950,459...262,964,410
Ensembl chr 1:262,950,462...262,964,394

G

Bardet-Biedl syndrome 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BBS2 mRNA

NCBI chr19:10,915,566...10,950,911
Ensembl chr19:10,915,476...10,950,921

G

branched chain amino acid transaminase 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:179,695,662...179,777,288

G

BCL2, apoptosis regulator

affects expression
decreases expression
multiple interactions

ISO
EXP

tributyltin affects the expression of BCL2 protein
tributyltin results in decreased expression of BCL2 protein
PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]

PMID:22223438 PMID:23743147 PMID:25743928 PMID:25895139 PMID:26079211 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

bradykinin receptor B1

decreases expression

EXP

tributyltin results in decreased expression of BDKRB1 mRNA

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973

G

beclin 1

decreases expression

EXP

tributyltin results in decreased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

ISO

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
tributyltin results in increased expression of BGLAP mRNA

PMID:22749964 PMID:25932594

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

biglycan

increases expression

EXP

tributyltin results in increased expression of BGN mRNA

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799

G

basic helix-loop-helix family, member e41

increases expression

ISO

tributyltin results in increased expression of BHLHE41 mRNA

NCBI chr 4:180,565,003...180,569,415
Ensembl chr 4:180,565,003...180,569,355

G

BicC family RNA binding protein 1

decreases expression

EXP

tributyltin results in decreased expression of BICC1 mRNA

NCBI chr20:17,448,745...17,685,887
Ensembl chr20:17,448,765...17,685,885

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

tributyltin results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 3

decreases expression

ISO

tributyltin results in decreased expression of BIRC3 mRNA

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

basic helix-loop-helix ARNT like 1

decreases expression

ISO

tributyltin results in decreased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739

G

Bcl2 modifying factor

increases expression

ISO

tributyltin results in increased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

bone morphogenetic protein receptor type 1B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BMPR1B mRNA

NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:233,211,525...233,544,311

G

BCL2 interacting protein 5

increases expression

ISO

tributyltin results in increased expression of BNIP5 mRNA

NCBI chr20:6,957,899...6,976,749
Ensembl chr20:6,959,534...6,974,853

G

biorientation of chromosomes in cell division 1-like 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BOD1L1 mRNA

NCBI chr14:73,320,880...73,375,662
Ensembl chr14:73,320,832...73,375,658

G

bromodomain containing 9

increases expression

EXP

tributyltin results in increased expression of BRD9 mRNA

NCBI chr 1:31,158,546...31,185,812
Ensembl chr 1:31,158,546...31,186,125

G

bassoon (presynaptic cytomatrix protein)

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of BSN mRNA

NCBI chr 8:117,663,447...117,754,412
Ensembl chr 8:117,670,334...117,754,412

G

B-box and SPRY domain containing

increases expression

ISO

tributyltin results in increased expression of BSPRY mRNA

NCBI chr 5:80,942,974...80,965,157
Ensembl chr 5:80,942,979...80,988,154

G

BTG anti-proliferation factor 2

decreases expression

ISO

tributyltin results in decreased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

similar to human chromosome 17 open reading frame 58

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of C10H17ORF58 mRNA

NCBI chr10:92,472,779...92,477,330
Ensembl chr10:92,471,934...92,477,330

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

EXP

tributyltin results in decreased expression of C1GALT1 mRNA

NCBI chr 4:36,894,440...36,932,434
Ensembl chr 4:36,894,488...36,932,441

G

complement C1r subcomponent like

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of C1RL mRNA

NCBI chr 4:159,080,495...159,097,066
Ensembl chr 4:159,080,495...159,097,066

G

complement C5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of C5 mRNA

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

complement C8 gamma chain

multiple interactions
affects binding

ISO

tributyltin inhibits the reaction [triphenyltin binds to C8G protein]
tributyltin inhibits the reaction [C8G protein binds to triphenyltin]
tributyltin binds to C8G protein

PMID:32879257 PMID:38614317

NCBI chr 3:28,718,648...28,720,232

G

carbonic anhydrase 13

increases expression

ISO

tributyltin results in increased expression of CAR13 mRNA

NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763

G

carbonic anhydrase 14

increases expression

EXP

tributyltin results in increased expression of CAR14 mRNA

NCBI chr 2:186,131,196...186,138,164
Ensembl chr 2:186,129,341...186,138,863

G

carbonic anhydrase 9

increases expression

EXP

tributyltin results in increased expression of CAR9 mRNA

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626

G

calcium voltage-gated channel subunit alpha1 H

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CACNA1H mRNA

NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771

G

calcium dependent secretion activator 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CADPS2 mRNA

NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:52,746,065...53,275,004

G

calmodulin 1

multiple interactions

EXP

CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]; tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calmodulin-like 4

increases expression

ISO

tributyltin results in increased expression of CALML4 mRNA

NCBI chr 8:72,218,870...72,230,650
Ensembl chr 8:72,218,613...72,230,650

G

calreticulin 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CALR3 mRNA

NCBI chr16:17,430,105...17,456,777
Ensembl chr16:17,430,153...17,457,198

G

calcium/calmodulin-dependent protein kinase II beta

increases activity
decreases expression
multiple interactions

ISO
EXP

tributyltin results in increased activity of CAMK2B protein
tributyltin results in decreased expression of CAMK2B mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of CAMK2B mRNA

PMID:20810541 PMID:31129395

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II delta

increases activity

ISO

tributyltin results in increased activity of CAMK2D protein

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

calcium/calmodulin-dependent protein kinase II gamma

increases activity

ISO

tributyltin results in increased activity of CAMK2G protein

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310

G

calmodulin binding transcription activator 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CAMTA1 mRNA

NCBI chr 5:166,791,639...167,639,502
Ensembl chr 5:166,793,101...167,639,733

G

calpain 12

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CAPN12 mRNA

NCBI chr 1:93,298,571...93,311,220
Ensembl chr 1:93,298,571...93,310,630

G

caspase 12

increases expression

EXP

tributyltin results in increased expression of CASP12 protein

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

multiple interactions
increases cleavage
decreases expression
increases activity
increases expression

EXP
ISO

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased activity of CASP3 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; SB 203580 inhibits the reaction [tributyltin results in increased expression of CASP3 protein]; tributyltin results in increased expression of and results in increased cleavage of CASP3 protein
tributyltin results in increased cleavage of CASP3 protein
DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP3 protein]
PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]
tributyltin results in increased expression of CASP3 protein; tributyltin results in increased expression of CASP3 protein modified form

PMID:17341481 PMID:21477642 PMID:21626652 PMID:21683754 PMID:22223438 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 6

multiple interactions
decreases expression

ISO

DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP6 protein]

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726

G

caspase 7

increases activity

EXP

tributyltin results in increased activity of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases expression
decreases expression

EXP

tributyltin results in increased expression of CASP8 protein
tributyltin results in decreased expression of CASP8 protein

PMID:23743147 PMID:28707438

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CASP9 mRNA

Ensembl chr 5:159,391,188...159,409,648

G

calpastatin

multiple interactions

ISO

CAST protein inhibits the reaction [tributyltin results in increased degradation of MAPT protein]; CAST protein inhibits the reaction [tributyltin results in increased degradation of NEFM protein]; CAST protein inhibits the reaction [tributyltin results in increased degradation of TUBB3 protein]

NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180

G

castor zinc finger 1

increases expression

ISO

tributyltin results in increased expression of CASZ1 mRNA

NCBI chr 5:164,527,083...164,677,037
Ensembl chr 5:164,527,112...164,677,014

G

catalase

multiple interactions
decreases activity
increases expression

EXP
ISO

[bisphenol A co-treated with tributyltin] results in increased expression of CAT mRNA; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CAT protein]
tributyltin results in decreased activity of CAT protein

PMID:26079211 PMID:26873547 PMID:31129395 PMID:33720505 PMID:34902535

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cerebellin 1 precursor

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CBLN1 mRNA

NCBI chr19:35,782,151...35,785,960
Ensembl chr19:35,781,952...35,785,960

G

coiled-coil domain containing 125

decreases expression

EXP

tributyltin results in decreased expression of CCDC125 mRNA

NCBI chr 2:33,542,916...33,568,501
Ensembl chr 2:33,543,300...33,568,288

G

coiled-coil domain containing 159

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CCDC159 mRNA

NCBI chr 8:28,733,988...28,742,646
Ensembl chr 8:28,725,003...28,744,890

G

C-C motif chemokine ligand 2

increases expression

ISO

tributyltin results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 25

increases expression

ISO

tributyltin results in increased expression of CCL25 mRNA

NCBI chr12:7,505,231...7,514,402
Ensembl chr12:7,505,235...7,514,385

G

C-C motif chemokine ligand 5

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in decreased secretion of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine ligand 7

decreases expression

EXP

tributyltin results in decreased expression of CCL7 mRNA

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

cyclin B1

multiple interactions
decreases expression

ISO

dimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CCNB1 protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

C-C motif chemokine receptor 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CCR1 mRNA

NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374

G

C-C motif chemokine receptor 7

increases expression

ISO

tributyltin results in increased expression of CCR7 mRNA

NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501

G

chaperonin containing TCP1 subunit 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CCT7 mRNA

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

CD22 molecule

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CD22 mRNA

NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:95,244,868...95,259,730

G

Cd300 molecule-like family member F

increases expression

ISO

tributyltin results in increased expression of CD300LF mRNA

NCBI chr10:100,858,924...100,875,111
Ensembl chr10:100,858,924...100,875,022

G

CD36 molecule

increases expression

ISO

tributyltin results in increased expression of CD36 mRNA

PMID:23428407 PMID:24848799

NCBI chr 4:18,209,088...18,302,142

G

Cd68 molecule

increases expression

EXP

tributyltin results in increased expression of CD68 protein

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

CD83 molecule

increases expression

EXP

tributyltin results in increased expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

cell division cycle 14A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CDC14A mRNA

NCBI chr 2:206,910,475...207,070,537
Ensembl chr 2:206,910,475...207,091,722

G

cell division cycle 25C

decreases expression
multiple interactions

ISO

tributyltin results in decreased expression of CDC25C protein
dimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CDC25C protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cell division cycle associated 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:159,321,014...159,325,068

G

cadherin 9

decreases expression

EXP

tributyltin results in decreased expression of CDH9 mRNA

NCBI chr 2:67,954,708...68,094,371
Ensembl chr 2:67,955,166...68,094,365

G

cadherin-related family member 2

increases expression

ISO

tributyltin results in increased expression of CDHR2 mRNA

NCBI chr17:9,881,979...9,917,698
Ensembl chr17:9,881,979...9,917,698

G

cell death-inducing p53 target 1

increases expression

EXP

tributyltin results in increased expression of CDIP1 mRNA

NCBI chr10:11,278,213...11,303,415
Ensembl chr10:11,293,827...11,303,415

G

cyclin-dependent kinase 13

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CDK13 mRNA

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257

G

cyclin-dependent kinase 5 regulatory subunit 1

decreases expression

ISO

tributyltin results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions
decreases expression

ISO

tributyltin results in increased expression of CDKN1A mRNA; tributyltin results in increased expression of CDKN1A protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]
tributyltin results in decreased expression of CDKN1A mRNA

PMID:28011154 PMID:31939706 PMID:36319700

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

ISO

2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of CDKN2B protein]

NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855

G

cerebellar degeneration-related protein 2

increases expression

ISO

tributyltin results in increased expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:184,934,129...184,968,863

G

chromodomain Y-like

increases expression

EXP

tributyltin results in increased expression of CDYL mRNA

NCBI chr17:29,188,697...29,409,805
Ensembl chr17:29,188,698...29,409,757

G

CCAAT/enhancer binding protein alpha

increases expression
multiple interactions

ISO

tributyltin results in increased expression of CEBPA mRNA
T 0070907 inhibits the reaction [tributyltin results in increased expression of CEBPA mRNA]

PMID:25932594 PMID:28011154 PMID:29787037

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

increases expression
affects expression

EXP
ISO

tributyltin results in increased expression of CEBPB mRNA
tributyltin affects the expression of CEBPB mRNA

PMID:21683754 PMID:29908848 PMID:38936095

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CUGBP, Elav-like family member 2

decreases expression

EXP

tributyltin results in decreased expression of CELF2 mRNA

NCBI chr17:75,813,928...76,639,300
Ensembl chr17:75,813,704...76,636,362

G

centrosomal protein 19

increases expression

EXP

tributyltin results in increased expression of CEP19 mRNA

NCBI chr11:82,182,868...82,192,134
Ensembl chr11:82,182,868...82,192,032

G

centrosomal protein 76

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CEP76 mRNA

NCBI chr18:63,444,389...63,478,358
Ensembl chr18:63,443,746...63,478,358

G

carboxylesterase 1D

increases expression

ISO

tributyltin results in increased expression of CES1D mRNA

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

cilia and flagella associated protein 210

decreases expression

EXP

tributyltin results in decreased expression of CFAP210 mRNA

NCBI chr 3:74,928,368...74,962,508
Ensembl chr 3:74,927,880...74,962,497

G

cilia and flagella associated protein 53

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CFAP53 mRNA

NCBI chr18:70,159,900...70,227,543
Ensembl chr18:70,159,898...70,227,540

G

complement factor D

increases expression

ISO

tributyltin results in increased expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

CF transmembrane conductance regulator

increases expression

ISO

tributyltin results in increased expression of CFTR mRNA

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

ISO

tributyltin results in decreased expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

choline O-acetyltransferase

decreases activity

ISO

tributyltin results in decreased activity of CHAT protein

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

chromodomain helicase DNA binding protein 9

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CHD9 mRNA

NCBI chr19:32,114,379...32,337,488
Ensembl chr19:32,115,920...32,319,042

G

chitinase 3 like 1

increases expression

EXP

tributyltin results in increased expression of CHI3L1 mRNA

NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825

G

choline kinase alpha

decreases expression

ISO

tributyltin results in decreased expression of CHKA mRNA

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752

G

charged multivesicular body protein 4C

increases expression

ISO

tributyltin results in increased expression of CHMP4C mRNA

NCBI chr 2:93,299,152...93,336,075
Ensembl chr 2:93,299,157...93,360,850

G

calcineurin-like EF hand protein 2

increases expression

ISO

tributyltin results in increased expression of CHP2 mRNA

NCBI chr 1:186,189,090...186,203,663
Ensembl chr 1:186,185,151...186,203,667

G

circadian associated repressor of transcription

increases expression

ISO

tributyltin results in increased expression of CIART mRNA

NCBI chr 2:186,108,744...186,113,778
Ensembl chr 2:186,108,752...186,112,246

G

CBY1 interacting BAR domain containing 1

increases expression
multiple interactions

EXP

tributyltin results in increased expression of CIBAR1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of CIBAR1 mRNA

NCBI chr 5:30,411,325...30,429,770
Ensembl chr 5:30,410,511...30,429,893

G

cell death-inducing DFFA-like effector a

increases expression

ISO

tributyltin results in increased expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

cell death-inducing DFFA-like effector c

increases expression
multiple interactions

ISO

tributyltin results in increased expression of CIDEC mRNA
T 0070907 inhibits the reaction [tributyltin results in increased expression of CIDEC mRNA]

PMID:23322813 PMID:29787037

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806

G

creatine kinase B

increases expression

ISO

tributyltin results in increased expression of CKB mRNA

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

claudin 14

decreases expression

ISO

tributyltin results in decreased expression of CLDN14 mRNA

NCBI chr11:46,701,940...46,799,049
Ensembl chr11:46,701,940...46,799,096

G

claudin 15

increases expression

ISO

tributyltin results in increased expression of CLDN15 mRNA

NCBI chr12:25,334,849...25,345,104
Ensembl chr12:25,334,849...25,343,477

G

claudin 16

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CLDN16 mRNA

NCBI chr11:87,795,106...87,814,396
Ensembl chr11:87,795,106...87,814,396

G

claudin 4

increases expression

ISO

tributyltin results in increased expression of CLDN4 mRNA

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958

G

claudin 5

multiple interactions
decreases expression

EXP

Phycocyanin inhibits the reaction [tributyltin results in decreased expression of CLDN5 protein]

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

claudin 7

increases expression

ISO

tributyltin results in increased expression of CLDN7 mRNA

NCBI chr10:55,188,670...55,190,871
Ensembl chr10:55,188,684...55,190,905

G

chloride intracellular channel 4

increases expression

ISO

tributyltin results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

chloride intracellular channel 5

increases expression

ISO

tributyltin results in increased expression of CLIC5 mRNA

NCBI chr 9:24,208,455...24,310,964
Ensembl chr 9:24,208,456...24,358,780

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

decreases expression

ISO

tributyltin results in decreased expression of CLPX mRNA

NCBI chr 8:74,700,602...74,740,244
Ensembl chr 8:74,700,662...74,744,762

G

calsyntenin 3

increases expression

ISO

tributyltin results in increased expression of CLSTN3 mRNA

NCBI chr 4:159,017,795...159,051,069
Ensembl chr 4:159,017,795...159,051,069

G

cytidine monophosphate N-acetylneuraminic acid synthetase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CMAS mRNA

NCBI chr 4:177,449,801...177,468,117
Ensembl chr 4:177,449,732...177,476,291

G

2',3'-cyclic nucleotide 3' phosphodiesterase

increases expression

ISO

tributyltin results in increased expression of CNP mRNA

NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063

G

collagen type I alpha 1 chain

increases expression

EXP

tributyltin results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

increases expression

EXP

tributyltin results in increased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type II alpha 1 chain

decreases expression

ISO

tributyltin results in decreased expression of COL2A1 mRNA

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

collagen type VI alpha 1 chain

increases expression

EXP

tributyltin results in increased expression of COL6A1 mRNA

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107

G

collagen type VI alpha 3 chain

increases expression

EXP

tributyltin results in increased expression of COL6A3 mRNA

NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:98,809,171...98,886,990

G

collagen type VII alpha 1 chain

multiple interactions
decreases expression

ISO

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of COL7A1 mRNA]

NCBI chr 8:118,483,364...118,515,736
Ensembl chr 8:118,483,364...118,517,439

G

collagen type IX alpha 3 chain

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of COL9A3 mRNA

NCBI chr 3:188,089,337...188,112,034
Ensembl chr 3:188,089,403...188,112,270

G

COMM domain containing 9

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of COMMD9 mRNA

NCBI chr 3:108,630,903...108,645,427
Ensembl chr 3:108,630,980...108,666,091

G

coronin 2A

increases expression

ISO

tributyltin results in increased expression of CORO2A mRNA

NCBI chr 5:65,623,820...65,677,483
Ensembl chr 5:65,623,823...65,654,602

G

cytochrome c oxidase subunit 7A1

increases expression

ISO

tributyltin results in increased expression of COX7A1 mRNA

PMID:24848799 PMID:31939706

NCBI chr 1:94,549,663...94,572,330
Ensembl chr 1:94,569,216...94,570,889

G

cytochrome c oxidase subunit 7A2 like

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of COX7A2L mRNA

NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:16,936,795...16,950,798

G

complexin 3

increases expression

EXP

tributyltin results in increased expression of CPLX3 mRNA

NCBI chr 8:66,899,438...66,906,200
Ensembl chr 8:66,899,438...66,906,200

G

copine 4

decreases expression

EXP

tributyltin results in decreased expression of CPNE4 mRNA

NCBI chr 8:114,056,152...114,531,855
Ensembl chr 8:113,993,703...114,531,855

G

carnitine palmitoyltransferase 1A

increases expression

ISO

tributyltin results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 2

increases expression

ISO

tributyltin results in increased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

cellular retinoic acid binding protein 1

decreases expression

EXP

tributyltin results in decreased expression of CRABP1 mRNA

NCBI chr 8:64,047,431...64,055,469
Ensembl chr 8:64,047,060...64,055,470

G

cellular retinoic acid binding protein 2

increases expression

EXP

tributyltin results in increased expression of CRABP2 mRNA

NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:175,707,312...175,728,385

G

cysteine-rich with EGF-like domains 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CRELD1 mRNA

NCBI chr 4:148,187,510...148,197,120
Ensembl chr 4:148,187,265...148,197,116

G

cAMP responsive element modulator

increases expression

EXP

tributyltin results in increased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

cysteine rich protein 1

increases expression

ISO

tributyltin results in increased expression of CRIP1 mRNA

NCBI chr 6:138,047,801...138,055,672
Ensembl chr 6:138,047,801...138,055,672

G

cytokine receptor-like factor 1

increases expression

EXP

tributyltin results in increased expression of CRLF1 mRNA

NCBI chr16:18,958,695...18,970,026
Ensembl chr16:18,957,956...18,969,970

G

cartilage acidic protein 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CRTAC1 mRNA

NCBI chr 1:251,040,963...251,182,920
Ensembl chr 1:251,028,143...251,182,689

G

colony stimulating factor 3

multiple interactions
increases expression

ISO

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of CSF3 mRNA]

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

cleavage stimulation factor subunit 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CSTF1 mRNA

NCBI chr 3:181,562,953...181,574,727
Ensembl chr 3:181,562,955...181,574,727

G

catenin alpha 1

increases expression

ISO

tributyltin results in increased expression of CTNNA1 mRNA

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007

G

catenin beta 1

increases expression

ISO

tributyltin results in increased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin K

multiple interactions
decreases expression

ISO

Tetrachlorodibenzodioxin inhibits the reaction [tributyltin results in decreased expression of CTSK mRNA]

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

C-X3-C motif chemokine ligand 1

increases expression

ISO

tributyltin results in increased expression of CX3CL1 mRNA

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

C-X-C motif chemokine ligand 13

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein

NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920

G

C-X-C motif chemokine ligand 14

increases expression

ISO

tributyltin results in increased expression of CXCL14 mRNA

NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,323,143...8,331,172

G

C-X-C motif chemokine ligand 3

decreases expression

ISO

tributyltin results in decreased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 2

decreases expression

ISO

tributyltin results in decreased expression of CXCR2 mRNA

NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602

G

C-X-C motif chemokine receptor 4

increases expression

ISO

tributyltin results in increased expression of CXCR4 mRNA

PMID:19371601 PMID:26314263

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome b5 type A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of CYB5A mRNA

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome b-245 beta chain

increases expression

EXP

tributyltin results in increased expression of CYBB protein

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome c, somatic

increases expression

ISO

tributyltin results in increased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

EXP

tributyltin results in increased expression of CYP11A1 protein

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 11, subfamily b, polypeptide 2

decreases expression
multiple interactions

ISO

tributyltin results in decreased expression of CYP11B1 mRNA
[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B1 mRNA

PMID:25765474 PMID:29549738

NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions
increases expression

ISO

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA
tributyltin results in increased expression of CYP11B2 mRNA

PMID:25765474 PMID:29549738

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

EXP

tributyltin results in decreased expression of CYP17A1 mRNA; tributyltin results in decreased expression of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases expression
decreases activity
increases activity

ISO
EXP

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP19A1 mRNA; [tributyltin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; [tributyltin co-treated with Testosterone] results in increased expression of CYP19A1 mRNA; Finasteride promotes the reaction [[tributyltin co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; tributyltin inhibits the reaction [CYP19A1 protein affects the metabolism of Testosterone]; tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione]; tributyltin promotes the reaction [[Finasteride co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]
tributyltin results in increased expression of CYP19A1 protein
[bisphenol A co-treated with tributyltin] results in increased expression of CYP19A1 protein
tributyltin results in decreased expression of CYP19A1 mRNA
tributyltin results in increased expression of CYP19A1 mRNA; tributyltin results in increased expression of CYP19A1 protein
tributyltin results in decreased activity of CYP19A1 protein
tributyltin results in increased activity of CYP19A1 protein

PMID:11522339 PMID:11751016 PMID:15941851 PMID:16996190 PMID:18310892 More...

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

ISO

tributyltin results in increased expression of CYP26A1 mRNA

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

ISO

tributyltin results in increased expression of CYP2S1 mRNA

NCBI chr 1:90,437,741...90,453,073
Ensembl chr 1:90,438,224...90,453,073

G

cytochrome P450, family 2, subfamily t, polypeptide 1

decreases expression

EXP

tributyltin results in decreased expression of CYP2T1 mRNA

NCBI chr 1:91,573,923...91,579,215
Ensembl chr 1:91,574,572...91,579,215

G

cytochrome P450, family 4, subfamily f, polypeptide 17

increases expression

EXP

tributyltin results in increased expression of CYP4F17 mRNA

NCBI chr 7:12,169,366...12,186,731
Ensembl chr 7:12,169,922...12,187,540

G

cytochrome P450 family 7 subfamily A member 1

increases expression

ISO

tributyltin results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cysteinyl leukotriene receptor 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of CYSLTR2 mRNA

NCBI chr15:54,599,043...54,638,314
Ensembl chr15:54,598,818...54,713,597

G

diazepam binding inhibitor

increases expression

ISO

tributyltin results in increased expression of DBI mRNA

NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450

G

diazepam binding inhibitor-like 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DBIL5 mRNA

NCBI chr10:61,571,774...61,572,786
Ensembl chr10:61,571,772...61,572,786

G

D-box binding PAR bZIP transcription factor

increases expression

ISO

tributyltin results in increased expression of DBP mRNA

NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205

G

doublecortin-like kinase 1

increases expression

ISO

tributyltin results in increased expression of DCLK1 mRNA

NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:141,571,983...141,861,090

G

doublecortin-like kinase 3

increases expression

ISO

tributyltin results in increased expression of DCLK3 mRNA

NCBI chr 8:120,279,916...120,332,362
Ensembl chr 8:120,279,757...120,332,432

G

DNA-damage inducible transcript 3

increases expression

ISO

tributyltin results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression

ISO

tributyltin results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

delta(4)-desaturase, sphingolipid 2

increases expression

ISO

tributyltin results in increased expression of DEGS2 mRNA

NCBI chr 6:133,360,449...133,377,677
Ensembl chr 6:133,360,457...133,364,422

G

DENN domain containing 10

increases expression

EXP

tributyltin results in increased expression of DENND10 mRNA

NCBI chr 1:269,937,023...269,960,506
Ensembl chr 1:269,936,895...269,962,853

G

DNA fragmentation factor subunit beta

increases response to substance
multiple interactions

ISO

DFFB protein results in increased susceptibility to tributyltin
DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP3 protein]; DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP6 protein]; DFFB protein promotes the reaction [tributyltin results in increased cleavage of PARP1 protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

diacylglycerol O-acyltransferase 1

increases expression
multiple interactions

ISO

tributyltin results in increased expression of DGAT1 mRNA
[tributyltin co-treated with LHB protein] results in increased expression of DGAT1 mRNA

PMID:23428407 PMID:38630605

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

diacylglycerol O-acyltransferase 2

increases expression

ISO

tributyltin results in increased expression of DGAT2 mRNA

NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566

G

dehydrogenase/reductase 9

decreases expression

ISO

tributyltin results in decreased expression of DHRS9 mRNA

NCBI chr 3:74,553,357...74,579,535
Ensembl chr 3:74,555,606...74,581,376

G

DEAH-box helicase 35

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DHX35 mRNA

NCBI chr 3:167,869,971...167,927,300
Ensembl chr 3:167,870,055...167,927,300

G

DEAH-box helicase 40

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of DHX40 mRNA
tributyltin results in increased expression of DHX40 mRNA

NCBI chr10:72,081,867...72,118,792
Ensembl chr10:72,081,867...72,118,958

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

ISO

tributyltin results in decreased expression of DKK1 mRNA

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

dickkopf WNT signaling pathway inhibitor 3

increases expression

EXP

tributyltin results in increased expression of DKK3 mRNA

NCBI chr 1:175,672,834...175,715,867
Ensembl chr 1:175,672,834...175,715,186

G

delta like non-canonical Notch ligand 1

decreases expression

ISO

tributyltin results in decreased expression of DLK1 mRNA

PMID:23322813 PMID:24513447

NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529

G

DNA methyltransferase 1-associated protein 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DMAP1 mRNA

NCBI chr 5:136,380,211...136,388,229
Ensembl chr 5:136,380,216...136,388,219

G

deleted in malignant brain tumors 1

increases expression

ISO

tributyltin results in increased expression of DMBT1 mRNA

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:195,047,713...195,126,704

G

dentin matrix acidic phosphoprotein 1

decreases expression
multiple interactions

ISO

tributyltin results in decreased expression of DMP1 mRNA
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of DMP1 mRNA]

PMID:25777084 PMID:25932594

NCBI chr14:5,833,111...5,867,154
Ensembl chr14:5,833,111...5,843,993

G

dynein axonemal intermediate chain 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DNAI4 mRNA

NCBI chr 5:123,016,480...123,105,283
Ensembl chr 5:123,016,480...123,105,283

G

DnaJ heat shock protein family (Hsp40) member C12

decreases expression

ISO

tributyltin results in decreased expression of DNAJC12 mRNA

NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251

G

DNA methyltransferase 3 beta

decreases expression

ISO

tributyltin results in decreased expression of DNMT3B mRNA

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

docking protein 4

increases expression

ISO

tributyltin results in increased expression of DOK4 mRNA

NCBI chr19:10,152,511...10,163,182
Ensembl chr19:10,152,458...10,164,190

G

dipeptidase 1

increases expression

ISO

tributyltin results in increased expression of DPEP1 mRNA

NCBI chr19:68,118,270...68,143,781
Ensembl chr19:68,118,453...68,143,775

G

dipeptidase 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DPEP2 mRNA

NCBI chr19:50,795,322...50,806,320
Ensembl chr19:50,795,327...50,801,757
Ensembl chr19:50,795,327...50,801,757

G

dermatopontin

increases expression

EXP

tributyltin results in increased expression of DPT mRNA

NCBI chr13:79,656,341...79,684,759
Ensembl chr13:79,655,985...79,684,758

G

dentin sialophosphoprotein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DSPP mRNA

NCBI chr14:5,870,232...5,876,339
Ensembl chr14:5,870,232...5,876,339

G

dual specificity phosphatase 10

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

dual specificity phosphatase 13B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DUSP13B mRNA

NCBI chr15:2,616,761...2,624,434
Ensembl chr15:2,609,049...2,624,887

G

dual specificity tyrosine phosphorylation regulated kinase 1B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of DYRK1B mRNA

NCBI chr 1:92,606,743...92,624,089
Ensembl chr 1:92,607,303...92,614,744

G

dysferlin

decreases expression

EXP

tributyltin results in decreased expression of DYSF mRNA

NCBI chr 4:118,048,460...118,248,273
Ensembl chr 4:118,047,989...118,248,273

G

ethylmalonyl-CoA decarboxylase 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ECHDC1 mRNA

NCBI chr 1:30,304,968...30,355,957
Ensembl chr 1:30,304,971...30,337,208

G

endothelin 1

increases expression

EXP

tributyltin results in increased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

eukaryotic elongation factor-2 kinase

increases expression

EXP

tributyltin results in increased expression of EEF2K mRNA

NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:184,824,420...184,888,048

G

EGF containing fibulin extracellular matrix protein 1

increases expression

EXP

tributyltin results in increased expression of EFEMP1 mRNA

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808

G

early growth response 1

decreases expression

ISO

tributyltin results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

increases expression

ISO

tributyltin results in increased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

early growth response 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of EGR4 mRNA

NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368

G

EH-domain containing 2

increases expression

EXP

tributyltin results in increased expression of EHD2 mRNA

NCBI chr 1:85,767,757...85,786,974
Ensembl chr 1:85,768,667...85,786,943

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

ISO

tributyltin results in increased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 4B

multiple interactions

ISO

tributyltin affects the expression of and results in increased phosphorylation of EIF4B protein

NCBI chr 7:135,085,259...135,107,054
Ensembl chr 7:135,085,066...135,107,064

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

tributyltin affects the expression of and results in increased phosphorylation of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

endosome-lysosome associated apoptosis and autophagy regulator 1

increases expression

ISO

tributyltin results in increased expression of ELAPOR1 mRNA

NCBI chr 2:198,777,323...198,856,497
Ensembl chr 2:198,777,323...198,856,497

G

E74 like ETS transcription factor 3

increases expression

ISO

tributyltin results in increased expression of ELF3 mRNA

NCBI chr13:49,242,265...49,247,102
Ensembl chr13:49,242,267...49,247,380

G

ETS transcription factor ELK4

increases expression

EXP

tributyltin results in increased expression of ELK4 mRNA

NCBI chr13:46,004,145...46,027,206
Ensembl chr13:46,004,182...46,027,199

G

ELMO domain containing 3

increases expression

ISO

tributyltin results in increased expression of ELMOD3 mRNA

NCBI chr 4:106,172,819...106,211,286
Ensembl chr 4:106,172,828...106,211,229

G

ELOVL fatty acid elongase 3

decreases expression

ISO

tributyltin results in decreased expression of ELOVL3 mRNA

NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559

G

ELOVL fatty acid elongase 7

increases expression

ISO

tributyltin results in increased expression of ELOVL7 mRNA

NCBI chr 2:41,522,695...41,592,021
Ensembl chr 2:41,522,738...41,592,020

G

enamelin

decreases expression
multiple interactions

ISO

tributyltin results in decreased expression of ENAM mRNA
Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of ENAM mRNA]

NCBI chr14:19,840,773...19,865,476
Ensembl chr14:19,840,773...19,865,468

G

endonuclease G

increases expression

ISO

tributyltin results in increased expression of ENDOG mRNA

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

eomesodermin

decreases expression

ISO

tributyltin results in decreased expression of EOMES mRNA

NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:127,059,215...127,067,070

G

erythrocyte membrane protein band 4.1-like 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of EPB41L1 mRNA

NCBI chr 3:165,389,295...165,512,821
Ensembl chr 3:165,389,293...165,510,498

G

epithelial cell adhesion molecule

increases expression

ISO

tributyltin results in increased expression of EPCAM mRNA

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

EPM2A interacting protein 1

increases expression
multiple interactions

EXP

tributyltin results in increased expression of EPM2AIP1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of EPM2AIP1 mRNA

NCBI chr 8:120,112,265...120,119,613
Ensembl chr 8:120,112,084...120,121,458

G

erb-b2 receptor tyrosine kinase 2

increases expression

ISO

tributyltin results in increased expression of ERBB2 mRNA

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

ETS transcription factor ERG

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ERG mRNA

NCBI chr11:48,148,149...48,370,472
Ensembl chr11:48,148,153...48,370,688

G

ER membrane-associated RNA degradation

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ERMARD mRNA

NCBI chr 1:64,656,414...64,675,803
Ensembl chr 1:64,656,529...64,675,806

G

estrogen receptor 1

multiple interactions
increases expression
decreases expression
affects expression

ISO
EXP

tributyltin binds to and results in increased activity of ESR1 protein; tributyltin results in increased expression of and affects the localization of ESR1 protein
tributyltin results in increased expression of ESR1 protein
tributyltin results in decreased expression of ESR1 protein
tributyltin affects the expression of ESR1 protein
fulvestrant inhibits the reaction [tributyltin affects the expression of ESR1 protein]
Estrogens inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; tributyltin inhibits the reaction [Estrogens results in increased expression of ESR1 protein]
tributyltin results in increased expression of ESR1 mRNA

PMID:23523586 PMID:25819109 PMID:27521499 PMID:28161095 PMID:29908848 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

affects expression

EXP

tributyltin affects the expression of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

electron transfer flavoprotein subunit beta lysine methyltransferase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ETFBKMT mRNA

NCBI chr 4:183,871,819...183,936,843
Ensembl chr 4:183,871,827...183,881,621

G

electron transfer flavoprotein dehydrogenase

increases expression
multiple interactions

ISO
EXP

tributyltin results in increased expression of ETFDH mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of ETFDH mRNA

PMID:24848799 PMID:31129395

NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:167,025,823...167,060,770

G

eva-1 homolog C

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of EVA1C mRNA

NCBI chr11:43,575,613...43,649,677
Ensembl chr11:43,576,332...43,649,834

G

exonuclease 3'-5' domain containing 2

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of EXD2 mRNA
tributyltin results in increased expression of EXD2 mRNA

NCBI chr 6:105,847,931...105,881,780
Ensembl chr 6:105,848,305...105,883,665

G

exonuclease 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of EXO1 mRNA

NCBI chr13:90,341,947...90,366,861
Ensembl chr13:90,342,018...90,366,861

G

exocyst complex component 3-like 4

increases expression

ISO

tributyltin results in increased expression of EXOC3L4 mRNA

NCBI chr 6:136,273,857...136,287,877
Ensembl chr 6:136,273,854...136,287,881

G

exosome component 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of EXOSC3 mRNA

NCBI chr 5:64,369,495...64,374,711
Ensembl chr 5:64,369,495...64,374,902

G

ezrin

increases expression

ISO

tributyltin results in increased expression of EZR mRNA

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

F11 receptor

decreases expression

ISO

tributyltin results in decreased expression of F11R mRNA

NCBI chr13:86,406,229...86,429,819
Ensembl chr13:86,406,218...86,429,816

G

coagulation factor XIII A1 chain

increases expression

EXP

tributyltin results in increased expression of F13A1 mRNA

NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948

G

F2R like trypsin receptor 1

increases expression

ISO

tributyltin results in increased expression of F2RL1 mRNA

NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954

G

fatty acid binding protein 3

increases expression

ISO

tributyltin results in increased expression of FABP3 mRNA

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

fatty acid binding protein 4

multiple interactions
increases expression

ISO

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of FABP4 protein; diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of FABP4 mRNA]; dibutyldichlorotin inhibits the reaction [tributyltin results in increased expression of FABP4 protein]; T 0070907 inhibits the reaction [tributyltin results in increased expression of FABP4 mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; triphenyltin chloride affects the reaction [tributyltin results in increased expression of FABP4 protein]
tributyltin results in increased expression of FABP4 mRNA; tributyltin results in increased expression of FABP4 protein

PMID:15993011 PMID:21622945 PMID:22197818 PMID:23322813 PMID:23428407 More...

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fatty acid binding protein 5

increases expression

ISO

tributyltin results in increased expression of FABP5 mRNA

PMID:23428407 PMID:31939706

NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127

G

family with sequence similarity 117, member A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FAM117A mRNA

NCBI chr10:80,778,229...80,822,119
Ensembl chr10:80,755,883...80,822,119

G

family with sequence similarity 131, member B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM131B mRNA

NCBI chr 4:72,167,667...72,176,924
Ensembl chr 4:72,165,578...72,176,858

G

family with sequence similarity 13, member A

increases expression

ISO

tributyltin results in increased expression of FAM13A mRNA

NCBI chr 4:89,386,685...89,485,940
Ensembl chr 4:89,388,569...89,485,988

G

family with sequence similarity 209

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM209 mRNA

NCBI chr 3:181,658,479...181,660,164
Ensembl chr 3:181,658,461...181,660,164

G

family with sequence similarity 227, member A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FAM227A mRNA

NCBI chr 7:113,054,751...113,096,898
Ensembl chr 7:113,054,751...113,096,868

G

family with sequence similarity 76, member B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FAM76B mRNA

NCBI chr 8:18,971,357...18,993,442
Ensembl chr 8:18,971,100...18,995,039

G

family with sequence similarity 83, member B

increases expression

ISO

tributyltin results in increased expression of FAM83B mRNA

NCBI chr 8:86,167,778...86,244,222
Ensembl chr 8:86,167,778...86,244,222

G

family with sequence similarity 98, member A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM98A mRNA

NCBI chr 6:25,626,108...25,640,767
Ensembl chr 6:25,625,984...25,640,767

G

Fas cell surface death receptor

increases expression

EXP

tributyltin results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fatty acid synthase

increases expression
multiple interactions

ISO

tributyltin results in increased expression of FASN mRNA
[tributyltin co-treated with LHB protein] results in increased expression of FASN mRNA

PMID:23322813 PMID:28011154 PMID:38630605

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

FAT atypical cadherin 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FAT4 mRNA

NCBI chr 2:123,855,289...123,984,716
Ensembl chr 2:123,855,289...123,984,716

G

F-box and leucine-rich repeat protein 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FBXL4 mRNA

NCBI chr 5:40,752,513...40,826,154
Ensembl chr 5:40,752,521...40,850,826

G

F-box and WD-40 domain protein 17

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FBXW17 mRNA

NCBI chr17:14,511,173...14,529,021
Ensembl chr17:14,511,194...14,530,275

G

Fc gamma binding protein

increases expression

ISO

tributyltin results in increased expression of FCGBP mRNA

NCBI chr 1:92,502,461...92,540,658
Ensembl chr 1:92,499,498...92,540,658

G

ferrochelatase

decreases activity

ISO

tributyltin results in decreased activity of FECH protein

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546

G

FERM domain containing kindlin 1

increases expression

ISO

tributyltin results in increased expression of FERMT1 mRNA

NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:140,624,434...140,666,419

G

fibrinogen alpha chain

decreases expression

ISO

tributyltin results in decreased expression of FGA mRNA

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577

G

fibrinogen beta chain

decreases expression

ISO

tributyltin results in decreased expression of FGB mRNA

NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434

G

fibrinogen gamma chain

decreases expression

ISO

tributyltin results in decreased expression of FGG mRNA

NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170

G

fibrinogen-like 2

increases expression

EXP

tributyltin results in increased expression of FGL2 mRNA

NCBI chr 4:14,602,762...14,608,405
Ensembl chr 4:14,602,771...14,608,405

G

FHF complex subunit HOOK interacting protein 1A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of FHIP1A mRNA

NCBI chr 2:173,319,252...173,489,514
Ensembl chr 2:173,319,257...173,453,902

G

formin homology 2 domain containing 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FHOD1 mRNA

NCBI chr19:50,116,415...50,135,868
Ensembl chr19:50,116,415...50,135,330

G

Fli-1 proto-oncogene, ETS transcription factor

increases expression

EXP

tributyltin results in increased expression of FLI1 mRNA

NCBI chr 8:39,089,526...39,209,511
Ensembl chr 8:39,089,533...39,208,557

G

fibronectin 1

multiple interactions

ISO

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

tributyltin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

decreases expression

ISO

tributyltin results in decreased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box O1

decreases expression

ISO

tributyltin results in decreased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

EXP

Fatty Acids, Omega-3 inhibits the reaction [tributyltin results in decreased expression of FSHB protein]; tributyltin inhibits the reaction [Estrogens deficiency results in increased secretion of FSHB protein]
tributyltin results in decreased expression of FSHB mRNA; tributyltin results in decreased expression of FSHB protein

PMID:28161095 PMID:32783468 PMID:35430282

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

follicle stimulating hormone receptor

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of FSHR protein
tributyltin results in increased expression of FSHR protein

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

G0/G1switch 2

increases expression

EXP

tributyltin results in increased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

EXP
ISO

[bisphenol A co-treated with tributyltin] results in increased expression of G6PC1 mRNA
tributyltin results in increased expression of G6PC1 protein

PMID:31129395 PMID:31306684

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glutamate decarboxylase 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GAD2 mRNA

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089

G

growth arrest and DNA-damage-inducible, beta

increases expression

EXP

tributyltin results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

growth arrest and DNA-damage-inducible, gamma

decreases expression

ISO

tributyltin results in decreased expression of GADD45G mRNA

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369

G

galanin and GMAP prepropeptide

decreases expression
increases activity

ISO

tributyltin results in decreased expression of GAL protein
tributyltin results in increased activity of GAL protein

PMID:27310180 PMID:36319700

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

galactose-3-O-sulfotransferase 3

multiple interactions
decreases expression

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GAL3ST3 mRNA
tributyltin results in decreased expression of GAL3ST3 mRNA

NCBI chr 1:212,022,989...212,032,802
Ensembl chr 1:212,023,000...212,032,801

G

galactokinase 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GALK2 mRNA

NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:133,563,538...133,696,528

G

polypeptide N-acetylgalactosaminyltransferase 12

increases expression

ISO

tributyltin results in increased expression of GALNT12 mRNA

NCBI chr 5:66,180,171...66,208,931
Ensembl chr 5:66,180,164...66,208,938

G

polypeptide N-acetylgalactosaminyltransferase 6

increases expression

ISO

tributyltin results in increased expression of GALNT6 mRNA

NCBI chr 7:133,668,612...133,715,909
Ensembl chr 7:133,668,615...133,698,439

G

galanin receptor 2

increases expression

EXP

tributyltin results in increased expression of GALR2 mRNA

NCBI chr10:102,012,086...102,016,057
Ensembl chr10:102,013,370...102,016,055

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

ISO

tributyltin results in decreased expression of GAPDH protein
tributyltin promotes the reaction [Tretinoin results in decreased expression of GAPDH protein]

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

GAR1 ribonucleoprotein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GAR1 mRNA

NCBI chr 2:221,049,471...221,056,749
Ensembl chr 2:221,049,473...221,056,749

G

GATA binding protein 4

increases expression
multiple interactions

EXP
ISO

tributyltin results in increased expression of GATA4 protein
[bisphenol A co-treated with tributyltin] results in increased expression of GATA4 protein

PMID:31129395 PMID:36319700

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

GATA binding protein 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GATA5 mRNA

NCBI chr 3:187,796,140...187,804,327
Ensembl chr 3:187,796,142...187,804,327

G

glutamyl-tRNA amidotransferase subunit C

increases expression

EXP

tributyltin results in increased expression of GATC mRNA

NCBI chr12:46,930,820...46,938,790
Ensembl chr12:46,930,630...46,938,776

G

guanylate binding protein 1

increases expression

ISO

tributyltin results in increased expression of GBP2B mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802

G

gastrulation brain homeobox 2

decreases expression

EXP

tributyltin results in decreased expression of GBX2 mRNA

NCBI chr 9:97,957,304...97,959,883
Ensembl chr 9:97,957,304...97,959,883

G

GRIP and coiled-coil domain containing 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GCC2 mRNA

NCBI chr20:26,788,472...26,836,728
Ensembl chr20:26,790,516...26,836,726

G

glucagon

decreases secretion
decreases expression

ISO

tributyltin results in decreased secretion of GCG protein
tributyltin results in decreased expression of GCG mRNA

NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533

G

glucagon receptor

decreases expression

ISO

tributyltin results in decreased expression of GCGR protein

NCBI chr10:106,306,803...106,314,970
Ensembl chr10:106,306,559...106,314,969

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

guanine deaminase

increases expression

EXP
ISO

tributyltin results in increased expression of GDA mRNA

PMID:21683754 PMID:31939706

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

glycerophosphodiester phosphodiesterase domain containing 1

increases expression

ISO

tributyltin results in increased expression of GDPD1 mRNA

NCBI chr10:72,318,716...72,381,143
Ensembl chr10:72,337,778...72,381,120

G

GTP binding protein overexpressed in skeletal muscle

increases expression

EXP

tributyltin results in increased expression of GEM mRNA

NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:30,011,592...30,022,542

G

guided entry of tail-anchored proteins factor 3, ATPase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GET3 mRNA

NCBI chr19:40,034,675...40,043,064
Ensembl chr19:40,034,967...40,043,061

G

glial fibrillary acidic protein

decreases expression
increases expression
multiple interactions

EXP

tributyltin results in decreased expression of GFAP protein
tributyltin results in increased expression of GFAP protein
Phycocyanin inhibits the reaction [tributyltin results in increased expression of GFAP protein]

PMID:23743147 PMID:26079211

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

gamma-glutamylamine cyclotransferase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GGACT mRNA

NCBI chr15:106,375,924...106,406,649
Ensembl chr15:106,366,120...106,404,004

G

gypsy retrotransposon integrase 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GIN1 mRNA

NCBI chr 9:105,740,914...105,762,357
Ensembl chr 9:105,742,094...105,762,357

G

GIPC PDZ domain containing family, member 2

increases expression

ISO

tributyltin results in increased expression of GIPC2 mRNA

NCBI chr 2:243,690,742...243,770,199
Ensembl chr 2:243,690,748...243,770,199

G

gap junction protein, alpha 1

decreases expression

EXP

tributyltin results in decreased expression of GJA1 protein

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glycerol kinase

increases expression

ISO

tributyltin results in increased expression of GK mRNA

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

glycine receptor, alpha 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GLRA3 mRNA

NCBI chr16:39,210,534...39,857,332
Ensembl chr16:39,210,536...39,856,764

G

G protein subunit gamma 11

increases expression

EXP

tributyltin results in increased expression of GNG11 mRNA

NCBI chr 4:32,977,681...32,983,121
Ensembl chr 4:32,977,664...32,984,438

G

gonadotropin releasing hormone 1

multiple interactions
decreases expression

EXP

tributyltin inhibits the reaction [Estrogens deficiency results in increased expression of GNRH1 mRNA]; tributyltin inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]
tributyltin results in decreased expression of GNRH1 mRNA

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

GON7 subunit of KEOPS complex

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GON7 mRNA

NCBI chr 6:127,647,389...127,663,276

G

glycerol-3-phosphate acyltransferase 3

increases expression

ISO

tributyltin results in increased expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552

G

glypican 6

increases expression

EXP

tributyltin results in increased expression of GPC6 mRNA

NCBI chr15:100,437,415...101,435,038
Ensembl chr15:100,437,943...101,435,027

G

glycoprotein nmb

decreases expression

ISO

tributyltin results in decreased expression of GPNMB mRNA

NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240

G

G protein-coupled receptor 155

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GPR155 mRNA

NCBI chr 3:78,623,931...78,677,803
Ensembl chr 3:78,607,976...78,677,803

G

G protein-coupled receptor 158

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GPR158 mRNA

NCBI chr17:88,685,879...89,152,659
Ensembl chr17:88,742,823...89,152,658

G

G protein-coupled receptor 45

decreases expression

EXP

tributyltin results in decreased expression of GPR45 mRNA

NCBI chr 9:52,713,825...52,801,826
Ensembl chr 9:52,783,090...52,801,941

G

glutamic--pyruvic transaminase 2

decreases expression

EXP

tributyltin results in decreased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917

G

glutathione peroxidase 6

increases expression

ISO

tributyltin results in increased expression of GPX6 mRNA

NCBI chr17:48,104,197...48,111,816
Ensembl chr17:48,104,197...48,111,007

G

growth factor receptor bound protein 14

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GRB14 mRNA

NCBI chr 3:69,976,331...70,091,921
Ensembl chr 3:69,976,339...70,091,921

G

gremlin 2, DAN family BMP antagonist

increases expression

ISO

tributyltin results in increased expression of GREM2 mRNA

NCBI chr13:89,310,897...89,403,856
Ensembl chr13:89,310,662...89,404,312

G

glutamate ionotropic receptor AMPA type subunit 1

decreases expression

EXP

tributyltin results in decreased expression of GRIA1 mRNA

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

EXP

tributyltin results in decreased expression of GRIA2 mRNA; tributyltin results in decreased expression of GRIA2 protein

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

EXP

tributyltin results in increased expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:125,103,782...125,369,679

G

glutamate ionotropic receptor AMPA type subunit 4

increases expression

EXP

tributyltin results in increased expression of GRIA4 mRNA

NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:9,847,052...10,319,881

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

EXP

tributyltin results in decreased expression of GRIN1 mRNA

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

EXP

tributyltin results in decreased expression of GRIN2A mRNA

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression

EXP

tributyltin results in increased expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

G protein-coupled receptor kinase 5

decreases expression

ISO

tributyltin results in decreased expression of GRK5 mRNA

NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928

G

glutaredoxin and cysteine rich domain containing 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GRXCR2 mRNA

NCBI chr18:34,235,734...34,249,139
Ensembl chr18:34,235,734...34,371,894

G

gasdermin E

increases expression

ISO

tributyltin results in increased expression of GSDME mRNA

NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:80,588,614...80,641,525

G

glutathione-disulfide reductase

multiple interactions
increases expression

EXP

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of GSR protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 5

increases expression

ISO

tributyltin results in increased expression of GSTA1 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase omega 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of GSTO1 mRNA

NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167

G

GTP binding protein 6 (putative)

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GTPBP6 mRNA

NCBI chr12:52,234,646...52,238,578
Ensembl chr12:52,234,572...52,238,578

G

guanylate cyclase 2C

increases expression

ISO

tributyltin results in increased expression of GUCY2C mRNA

NCBI chr 4:171,299,715...171,380,296
Ensembl chr 4:171,299,740...171,380,296

G

guanylate cyclase 2E

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of GUCY2D mRNA

NCBI chr10:54,453,753...54,478,639
Ensembl chr10:54,457,844...54,472,898

G

granzyme A

increases expression

ISO

tributyltin results in increased expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

H2A clustered histone 4

increases expression

ISO

tributyltin results in increased expression of H2AC4 mRNA

NCBI chr17:47,495,624...47,496,127
Ensembl chr17:47,495,546...47,496,173

G

H2A.X variant histone

multiple interactions
increases expression
increases phosphorylation

EXP
ISO

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of H2AX protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]

PMID:26079211 PMID:31401084 PMID:36319700

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H3 clustered histone 1

increases expression

ISO

tributyltin results in increased expression of H3C1 mRNA

NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,795,396...41,797,281
Ensembl chr17:41,795,396...41,797,281

G

hydroxyacyl-CoA dehydrogenase

increases expression

ISO

tributyltin results in increased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression

ISO

tributyltin results in increased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

ISO

tributyltin results in increased expression of HADHB mRNA

PMID:23428407 PMID:24848799

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

hepcidin antimicrobial peptide

decreases expression

ISO

tributyltin results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

heart and neural crest derivatives expressed 1

decreases expression

ISO

tributyltin results in decreased expression of HAND1 mRNA

NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684

G

hydroxyacid oxidase 2

increases expression

EXP

tributyltin results in increased expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

histone acetyltransferase 1

increases activity

EXP

tributyltin results in increased activity of HAT1 protein

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

haloacid dehalogenase like hydrolase domain containing 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of HDHD5 mRNA

NCBI chr 4:155,372,781...155,425,496
Ensembl chr 4:155,390,916...155,425,601

G

HECT domain E3 ubiquitin protein ligase 2

increases expression

EXP

tributyltin results in increased expression of HECTD2 mRNA

NCBI chr 1:243,687,248...243,756,069
Ensembl chr 1:243,687,923...243,756,069

G

hephaestin

increases expression

ISO

tributyltin results in increased expression of HEPH mRNA

NCBI chr X:65,160,628...65,412,457
Ensembl chr X:65,305,773...65,412,453

G

Holliday junction recognition protein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of HJURP mRNA

NCBI chr 9:96,301,183...96,315,587
Ensembl chr 9:96,302,530...96,315,657

G

hexokinase domain containing 1

increases expression

ISO

tributyltin results in increased expression of HKDC1 mRNA

NCBI chr20:30,878,037...30,917,044
Ensembl chr20:30,878,319...30,916,704

G

5-hydroxymethylcytosine binding, ES cell specific

increases expression

EXP

tributyltin results in increased expression of HMCES mRNA

NCBI chr 4:121,950,129...121,972,937
Ensembl chr 4:121,950,840...121,972,891

G

high mobility group AT-hook 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of HMGA1 mRNA

NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of HMGCS2 mRNA
tributyltin results in increased expression of HMGCS2 mRNA

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

hyaluronan-mediated motility receptor

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390

G

heme oxygenase 1

increases expression

EXP
ISO

tributyltin results in increased expression of HMOX1 protein

PMID:28707438 PMID:36858641

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heterogeneous nuclear ribonucleoprotein F

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of HNRNPF mRNA

NCBI chr 4:152,755,668...152,776,867
Ensembl chr 4:152,722,617...152,815,769

G

homeobox A2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of HOXA2 mRNA

NCBI chr 4:82,593,389...82,597,589
Ensembl chr 4:82,593,389...82,595,692

G

15-hydroxyprostaglandin dehydrogenase

increases expression

ISO

tributyltin results in increased expression of HPGD mRNA

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831

G

histamine receptor H 1

decreases expression

ISO

tributyltin results in decreased expression of HRH1 mRNA

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

histamine receptor H3

decreases expression

EXP

tributyltin results in decreased expression of HRH3 mRNA

NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259

G

homologous recombination factor with OB-fold

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of HROB mRNA

NCBI chr10:87,705,846...87,722,635
Ensembl chr10:87,706,194...87,722,635

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity
multiple interactions
increases expression

ISO

tributyltin results in decreased activity of HSD11B2 protein
Cycloheximide promotes the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; LG 100754 inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 protein]; tributyltin results in increased expression of and results in increased activity of HSD11B2 protein

PMID:16184081 PMID:22796344 PMID:31927052

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 1

increases activity
increases expression

ISO

tributyltin results in increased activity of HSD17B1 protein
tributyltin results in increased expression of HSD17B1 mRNA

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of HSD17B3 mRNA
tributyltin results in decreased expression of HSD17B3 mRNA; tributyltin results in decreased expression of HSD17B3 protein

PMID:31129395 PMID:35430282

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

hydroxysteroid (17-beta) dehydrogenase 6

increases expression

ISO

tributyltin results in increased expression of HSD17B6 mRNA

NCBI chr 7:831,407...850,950
Ensembl chr 7:831,421...850,873

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

EXP

tributyltin results in decreased expression of HSD3B1 mRNA; tributyltin results in decreased expression of HSD3B1 protein

NCBI chr 2:188,858,574...188,864,694

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

increases expression
decreases expression

ISO

tributyltin results in increased expression of HSD3B2 mRNA
tributyltin results in decreased expression of HSD3B2 mRNA

PMID:23523586 PMID:29549738

NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

decreases expression

ISO

tributyltin results in decreased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

multiple interactions
decreases expression
increases expression

ISO

4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]
tributyltin results in decreased expression of HSPA5 mRNA

PMID:23743301 PMID:27678064

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 8

decreases expression

ISO

tributyltin results in decreased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family B (small) member 8

increases expression

EXP

tributyltin results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937

G

5-hydroxytryptamine receptor 2A

decreases expression

ISO

tributyltin results in decreased expression of HTR2A mRNA

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

intercellular adhesion molecule 1

increases expression

ISO

tributyltin results in increased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 3

decreases expression

ISO

tributyltin results in decreased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

increases expression
multiple interactions

ISO

tributyltin results in increased expression of IDH3A mRNA
IDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]

PMID:23428407 PMID:26961604

NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:63,867,820...63,887,223

G

immediate early response 3

increases expression

EXP

tributyltin results in increased expression of IER3 mRNA

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

immediate early response 3 interacting protein 1, pseudogene 1

increases expression
multiple interactions

EXP

tributyltin results in increased expression of IER3IP1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of IER3IP1 mRNA

NCBI chr 4:133,898,662...133,899,156
Ensembl chr 4:133,887,903...133,898,847

G

interferon, alpha-inducible protein 27 like 2A

increases expression

ISO

tributyltin results in increased expression of IFI27L2A mRNA

NCBI chr 6:128,363,658...128,365,144
Ensembl chr 6:128,363,658...128,365,146

G

interferon induced transmembrane protein 3

increases expression

EXP

tributyltin results in increased expression of IFITM3 mRNA

NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:205,481,168...205,547,920

G

interferon alpha and beta receptor subunit 2

increases expression

ISO

tributyltin results in increased expression of IFNAR2 mRNA

NCBI chr11:44,099,574...44,131,941
Ensembl chr11:44,099,753...44,131,937

G

interferon gamma

affects expression
multiple interactions

ISO

tributyltin affects the expression of IFNG mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IFNG protein]; tributyltin results in increased expression of and results in increased secretion of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

immunoglobulin superfamily, DCC subclass, member 4

increases expression

ISO

tributyltin results in increased expression of IGDCC4 mRNA

NCBI chr 8:74,517,082...74,552,834
Ensembl chr 8:74,517,086...74,552,834

G

insulin-like growth factor binding protein 1

decreases expression

ISO

tributyltin results in decreased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

immunoglobulin kappa variable like 15

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of IGKVL15 mRNA

NCBI chr19:3,099,541...3,100,174
Ensembl chr 4:101,944,224...101,944,538
Ensembl chr19:101,944,224...101,944,538

G

immunoglobulin superfamily, member 11

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of IGSF11 mRNA

NCBI chr11:75,238,706...75,389,748
Ensembl chr11:75,236,545...75,390,425

G

immunoglobulin superfamily, member 23

increases expression

ISO

tributyltin results in increased expression of IGSF23 mRNA

NCBI chr 1:88,719,000...88,738,391
Ensembl chr 1:88,719,401...88,746,219

G

immunoglobulin superfamily, member 9

increases expression

ISO

tributyltin results in increased expression of IGSF9 mRNA

NCBI chr13:87,480,979...87,497,974
Ensembl chr13:87,481,279...87,497,974

G

Indian hedgehog signaling molecule

increases expression

ISO

tributyltin results in increased expression of IHH mRNA

NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203

G

interleukin 10

increases expression

ISO

tributyltin results in increased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 13

decreases expression

EXP

tributyltin results in decreased expression of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 15

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in decreased secretion of IL15 protein

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 16

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in decreased secretion of IL16 protein

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 18

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in increased secretion of IL18 protein

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 alpha

multiple interactions
increases expression

ISO

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [tributyltin results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein]; Rotenone inhibits the reaction [tributyltin results in increased expression of IL1A protein]

PMID:8875956 PMID:9221826

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

affects secretion
increases secretion
increases expression
multiple interactions

ISO

tributyltin affects the secretion of IL1B protein
tributyltin results in increased secretion of IL1B protein
tributyltin results in increased expression of IL1B mRNA
tributyltin results in increased expression of IL1B mRNA; tributyltin results in increased expression of IL1B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [tributyltin affects the secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of IL1B mRNA]; 5-(3-(4-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl))propanamide inhibits the reaction [tributyltin results in increased secretion of IL1B protein]; CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL1B protein]; tributyltin results in increased expression of and results in increased secretion of IL1B protein; U 0126 affects the reaction [tributyltin affects the secretion of IL1B protein]

PMID:25382723 PMID:29951691 PMID:35405286 PMID:36319700 PMID:39914831

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

decreases expression

ISO

tributyltin results in decreased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 3 receptor subunit alpha

increases expression

ISO

tributyltin results in increased expression of IL3RA mRNA

NCBI chr12:21,431,848...21,437,336
Ensembl chr12:21,431,848...21,437,250

G

interleukin 4

decreases expression

EXP

tributyltin results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5 receptor subunit alpha

decreases expression

EXP

tributyltin results in decreased expression of IL5RA mRNA

NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:141,171,158...141,220,943

G

interleukin 6

increases expression
multiple interactions

EXP
ISO

tributyltin results in increased expression of IL6 protein
tributyltin results in increased expression of IL6 mRNA; tributyltin results in increased expression of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of IL6 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of IL6 protein]; 5-(3-(4-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl))propanamide inhibits the reaction [tributyltin results in increased expression of IL6 protein]; CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL6 protein]; tributyltin results in increased expression of and results in increased secretion of IL6 protein

PMID:23743147 PMID:29951691 PMID:30172001 PMID:35405286 PMID:39914831

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 9

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in increased secretion of IL9 protein

NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,117,028...8,120,151

G

interphotoreceptor matrix proteoglycan 2

decreases expression

EXP

tributyltin results in decreased expression of IMPG2 mRNA

NCBI chr11:57,787,914...57,887,450
Ensembl chr11:57,787,914...58,033,766

G

inhibin subunit beta B

increases expression

EXP

tributyltin results in increased expression of INHBB mRNA

NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609

G

insulin 1

increases expression
multiple interactions
increases secretion

ISO
EXP

tributyltin results in increased expression of INS1 mRNA; tributyltin results in increased expression of INS1 protein
Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin results in increased secretion of INS1 protein]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]
tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]

PMID:27384973 PMID:28161095 PMID:28180948 PMID:28397090 PMID:30172001 More...

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions
increases expression

ISO

tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]
tributyltin results in increased expression of INS2 mRNA
[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA; [tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of DMP1 mRNA]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased secretion of TNFRSF11B protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]; tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]

PMID:22197818 PMID:25932594 PMID:28180948 PMID:31016361 PMID:31306684 More...

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

insulin induced gene 2

decreases expression

ISO

tributyltin results in decreased expression of INSIG2 mRNA

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

insulin receptor

affects methylation
multiple interactions

ISO

tributyltin affects the methylation of INSR gene
tributyltin results in decreased expression of and results in decreased phosphorylation of INSR protein

PMID:28011154 PMID:28397090

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

interferon regulatory factor 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of IRF5 mRNA

NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552

G

insulin receptor substrate 1

multiple interactions
increases expression

ISO

tributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein
tributyltin results in increased expression of IRS1 mRNA

PMID:28397090 PMID:30027469

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

isochorismatase domain containing 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ISOC1 mRNA

NCBI chr18:54,356,757...54,377,170
Ensembl chr18:54,356,734...54,377,170

G

isochorismatase domain containing 2b

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ISOC2B mRNA

NCBI chr 1:78,001,735...78,022,565
Ensembl chr 1:78,001,735...78,022,564

G

integrin subunit alpha 4

increases expression

ISO

tributyltin results in increased expression of ITGA4 mRNA

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

integrin subunit alpha 6

increases expression

ISO

tributyltin results in increased expression of ITGA6 mRNA

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

integrin subunit alpha L

increases expression

ISO

tributyltin results in increased expression of ITGAL mRNA

NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225

G

integrin subunit alpha M

multiple interactions
increases expression

ISO
EXP

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of ITGAM mRNA]
[Phycocyanin co-treated with tributyltin] results in increased expression of ITGAM protein

PMID:22749964 PMID:26079211

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit beta 2

increases expression
multiple interactions
affects localization

ISO

tributyltin results in increased expression of ITGB2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin affects the localization of ITGB2 protein]

PMID:20883105 PMID:26314263

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

integrin subunit beta 4

increases expression

ISO

tributyltin results in increased expression of ITGB4 mRNA

NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932

G

intelectin 1

increases expression

EXP

tributyltin results in increased expression of ITLN1 mRNA

NCBI chr13:86,464,641...86,490,655
Ensembl chr13:86,464,669...86,490,651

G

inositol 1,4,5-trisphosphate receptor, type 3

increases expression

ISO

tributyltin results in increased expression of ITPR3 mRNA

NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184

G

intersectin 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ITSN2 mRNA

NCBI chr 6:33,336,086...33,446,818
Ensembl chr 6:33,336,441...33,446,818

G

junctional adhesion molecule 2

increases expression

ISO

tributyltin results in increased expression of JAM2 mRNA

NCBI chr11:37,316,287...37,366,517
Ensembl chr11:37,317,511...37,367,510

G

junctional adhesion molecule 3

increases expression

ISO

tributyltin results in increased expression of JAM3 mRNA

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

joining chain of multimeric IgA and IgM

increases expression

ISO

tributyltin results in increased expression of JCHAIN mRNA

NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,822,976...19,838,307

G

junctional cadherin complex regulator

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of JHY mRNA

NCBI chr 8:50,173,602...50,230,429
Ensembl chr 8:50,173,123...50,230,542

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation

ISO

tributyltin results in increased phosphorylation of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

tributyltin results in increased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

KN motif and ankyrin repeat domains 2

increases expression

EXP

tributyltin results in increased expression of KANK2 mRNA

NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:28,587,770...28,616,993

G

kelch repeat and BTB domain containing 11

increases expression

ISO

tributyltin results in increased expression of KBTBD11 mRNA

NCBI chr16:81,318,596...81,340,334
Ensembl chr16:81,313,093...81,340,390

G

potassium two pore domain channel subfamily K member 3

increases expression

ISO

tributyltin results in increased expression of KCNK3 mRNA

NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:31,483,140...31,519,061

G

potassium voltage-gated channel subfamily Q member 1

increases expression

ISO

tributyltin results in increased expression of KCNQ1 mRNA

NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:207,721,131...208,054,072

G

potassium channel tetramerization domain containing 8

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of KCTD8 mRNA

NCBI chr14:39,127,210...39,372,118
Ensembl chr14:39,127,379...39,372,078

G

Kelch-like ECH-associated protein 1

decreases expression

ISO

tributyltin results in decreased expression of KEAP1 protein

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

kinesin family member 2A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of KIF2A mRNA

NCBI chr 2:40,101,548...40,164,780
Ensembl chr 2:40,101,548...40,186,618

G

kinesin family member 3B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of KIF3B mRNA

NCBI chr 3:162,218,621...162,258,191
Ensembl chr 3:162,218,682...162,258,581

G

KiSS-1 metastasis-suppressor

multiple interactions

EXP

tributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]

NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906

G

KLF transcription factor 15

decreases expression

ISO

tributyltin results in decreased expression of KLF15 mRNA

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373

G

KLF transcription factor 2

increases expression

ISO

tributyltin results in increased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768

G

KLF transcription factor 4

increases expression

ISO

tributyltin results in increased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

kelch-like family member 9

increases expression

EXP

tributyltin results in increased expression of KLHL9 mRNA

NCBI chr 5:108,449,492...108,453,676
Ensembl chr 5:108,437,583...108,454,140

G

kininogen 1

increases expression

ISO

tributyltin results in increased expression of KNG1 mRNA

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148

G

kinetochore-localized astrin/SPAG5 binding protein

decreases expression

EXP

tributyltin results in decreased expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:126,254,663...126,274,418

G

keratin 19

increases expression

ISO

tributyltin results in increased expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

keratin 79

increases expression

ISO

tributyltin results in increased expression of KRT79 mRNA

NCBI chr 7:134,935,395...134,946,447
Ensembl chr 7:134,935,396...134,947,286

G

kinase suppressor of ras 1

increases expression

ISO

tributyltin results in increased expression of KSR1 mRNA

NCBI chr10:64,459,786...64,596,083
Ensembl chr10:64,459,786...64,596,082

G

lysosomal-associated membrane protein 3

decreases expression

EXP

tributyltin results in decreased expression of LAMP3 mRNA

NCBI chr11:94,657,817...94,726,451
Ensembl chr11:94,661,399...94,726,195

G

leucyl-tRNA synthetase 2, mitochondrial

affects expression

ISO

tributyltin affects the expression of LARS2 mRNA

NCBI chr 8:131,887,728...131,983,866
Ensembl chr 8:131,887,753...131,983,866

G

leptin

increases expression
multiple interactions
decreases expression
increases secretion

ISO
EXP

tributyltin results in increased expression of LEP mRNA
tributyltin results in increased expression of LEP protein
[Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein
tributyltin results in decreased expression of LEP protein
tributyltin results in increased secretion of LEP protein

PMID:27310180 PMID:28011154 PMID:28161095 PMID:29787037 PMID:30172001

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

leptin receptor

decreases expression

ISO

tributyltin results in decreased expression of LEPR mRNA

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

LETM1 domain containing 1

increases expression

ISO

tributyltin results in increased expression of LETMD1 mRNA

NCBI chr 7:133,461,920...133,476,592
Ensembl chr 7:133,462,825...133,476,591

G

galectin 4

increases expression

ISO

tributyltin results in increased expression of LGALS4 mRNA

NCBI chr 1:93,248,463...93,260,002
Ensembl chr 1:93,252,283...93,259,998

G

luteinizing hormone subunit beta

multiple interactions
decreases expression
increases secretion
decreases secretion

EXP
ISO

[bisphenol A co-treated with tributyltin] results in increased secretion of LHB protein; Fatty Acids, Omega-3 inhibits the reaction [tributyltin results in decreased expression of LHB protein]; tributyltin inhibits the reaction [Estrogens deficiency results in increased secretion of LHB protein]; tributyltin inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]; tributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]
[tributyltin co-treated with LHB protein] results in decreased secretion of CCL5 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of CCL8 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of IL15 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of IL16 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of PDGFAA protein; [tributyltin co-treated with LHB protein] results in increased expression of ASCL1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of DGAT1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of FASN mRNA; [tributyltin co-treated with LHB protein] results in increased expression of PLIN1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of PNPLA2 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of SREBF1 mRNA; [tributyltin co-treated with LHB protein] results in increased secretion of IL18 protein; [tributyltin co-treated with LHB protein] results in increased secretion of IL9 protein
tributyltin results in decreased expression of LHB mRNA; tributyltin results in decreased expression of LHB protein
tributyltin results in increased secretion of LHB protein
tributyltin results in decreased secretion of LHB protein

PMID:28161095 PMID:31129395 PMID:32783468 PMID:35430282 PMID:38630605

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

luteinizing hormone/choriogonadotropin receptor

increases expression

EXP

tributyltin results in increased expression of LHCGR mRNA; tributyltin results in increased expression of LHCGR protein

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061

G

lon peptidase 1, mitochondrial

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of LONP1 mRNA

NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427

G

lysyl oxidase

increases expression

EXP

tributyltin results in increased expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

lysyl oxidase-like 2

increases expression

EXP

tributyltin results in increased expression of LOXL2 mRNA

NCBI chr15:51,091,547...51,182,843
Ensembl chr15:51,069,997...51,182,842

G

lysyl oxidase-like 4

decreases expression

ISO

tributyltin results in decreased expression of LOXL4 mRNA

NCBI chr 1:251,345,445...251,365,640
Ensembl chr 1:251,347,238...251,365,577

G

lysophosphatidylcholine acyltransferase 3

increases expression

ISO

tributyltin results in increased expression of LPCAT3 mRNA

NCBI chr 4:159,154,690...159,196,176
Ensembl chr 4:159,154,158...159,196,358

G

lipin 1

increases expression

EXP

tributyltin results in increased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

lipoprotein lipase

multiple interactions
increases expression

ISO

T 0070907 inhibits the reaction [tributyltin results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]

PMID:22197818 PMID:23322813 PMID:24513447 PMID:28011154 PMID:29787037

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine rich repeats and calponin homology domain containing 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of LRCH2 mRNA

NCBI chr X:115,903,760...115,986,569
Ensembl chr X:115,903,767...115,986,266

G

leucine rich repeat and fibronectin type III domain containing 3

decreases expression

ISO

tributyltin results in decreased expression of LRFN3 mRNA

NCBI chr 1:94,744,315...94,751,001
Ensembl chr 1:94,744,321...94,751,178

G

LDL receptor related protein 11

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of LRP11 mRNA

NCBI chr 1:3,868,665...3,928,513
Ensembl chr 1:3,899,985...3,928,507

G

LDL receptor related protein 2

decreases expression

ISO

tributyltin results in decreased expression of LRP2 mRNA

NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:74,597,148...74,754,535

G

leucine rich repeat containing 1

increases expression

ISO

tributyltin results in increased expression of LRRC1 mRNA

NCBI chr 8:87,120,281...87,289,748
Ensembl chr 8:87,119,975...87,286,853

G

leucine rich repeat containing 69

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of LRRC69 mRNA

NCBI chr 5:32,820,840...32,979,176
Ensembl chr 5:32,820,840...32,979,375

G

leucine rich repeat containing 8 VRAC subunit B

increases expression

ISO

tributyltin results in increased expression of LRRC8B mRNA

NCBI chr14:4,655,273...4,721,648
Ensembl chr14:4,655,273...4,721,076

G

leucine-rich repeats and death domain containing 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of LRRD1 mRNA

NCBI chr 4:31,219,573...31,247,702
Ensembl chr 4:31,219,477...31,241,491

G

leucine-rich repeats and transmembrane domains 1

increases expression

ISO

tributyltin results in increased expression of LRTM1 mRNA

NCBI chr16:4,216,947...4,224,447

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of LSM2 mRNA

NCBI chr20:3,848,120...3,853,298
Ensembl chr20:3,848,119...3,851,891

G

lactotransferrin

increases expression

ISO

tributyltin results in increased expression of LTF mRNA

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189

G

Ly49 inhibitory receptor 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of LY49I4 mRNA

NCBI chr 4:165,852,010...165,873,606
Ensembl chr 4:165,852,010...165,873,606

G

lymphocyte antigen 6 family member D

decreases expression

ISO

tributyltin results in decreased expression of LY6D mRNA

NCBI chr 7:108,532,207...108,533,943
Ensembl chr 7:108,532,215...108,533,716

G

MAF bZIP transcription factor A

decreases expression

EXP
ISO

tributyltin results in decreased expression of MAFA mRNA

NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:109,313,121...109,315,760

G

MAGE family member A4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MAGEA4 mRNA

NCBI chr X:155,073,718...155,080,164
Ensembl chr X:44,216,453...44,226,182

G

MAGE family member B18

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MAGEB18 mRNA

NCBI chr X:60,861,961...61,456,154
Ensembl chr X:60,850,421...62,000,917

G

mitogen activated protein kinase kinase 3

decreases expression

ISO

tributyltin results in decreased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

ISO

tributyltin results in increased expression of and results in increased phosphorylation of MAP3K5 protein

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen-activated protein kinase kinase kinase 6

decreases expression

ISO

tributyltin results in decreased expression of MAP3K6 mRNA

NCBI chr 5:150,724,029...150,736,113
Ensembl chr 5:150,724,216...150,736,111

G

mitogen activated protein kinase kinase kinase 7

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MAP3K7 mRNA
tributyltin results in increased expression of MAP3K7 mRNA

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

ISO

tributyltin results in decreased expression of MAP4K4 mRNA

NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:49,696,700...49,822,353

G

mitogen activated protein kinase 1

multiple interactions
increases expression
increases phosphorylation
increases activity
decreases expression

ISO
EXP

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK1 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]
tributyltin results in increased expression of MAPK1 protein
tributyltin results in decreased expression of MAPK1 mRNA

PMID:11042092 PMID:18989867 PMID:22223438 PMID:23523586 PMID:23743147 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen-activated protein kinase 12

decreases expression

ISO

tributyltin results in decreased expression of MAPK12 mRNA

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 14

increases expression

ISO

tributyltin results in increased expression of MAPK14 mRNA

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases expression
increases phosphorylation
increases activity

ISO
EXP

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK3 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK3 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK3 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]
tributyltin results in increased expression of MAPK3 protein

PMID:11042092 PMID:18989867 PMID:22223438 PMID:23523586 PMID:23743147 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation

ISO

tributyltin results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

microtubule-associated protein tau

increases cleavage
multiple interactions
increases degradation

EXP
ISO

tributyltin results in increased cleavage of MAPT protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of MAPT protein]

PMID:23743147 PMID:33481012

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

MBL associated serine protease 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MASP1 mRNA

NCBI chr11:90,839,081...90,909,922
Ensembl chr11:90,839,061...90,917,470

G

melanocortin 2 receptor

multiple interactions

ISO

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of MC2R mRNA

NCBI chr18:64,279,878...64,291,775
Ensembl chr18:64,277,360...64,291,881

G

MAPK regulated co-repressor interacting protein 2

increases expression

ISO

tributyltin results in increased expression of MCRIP2 mRNA

NCBI chr10:15,388,325...15,393,302
Ensembl chr10:15,388,325...15,398,730

G

mitochondrial calcium uniporter regulator 1

increases expression

ISO

tributyltin results in increased expression of MCUR1 mRNA

NCBI chr17:21,348,490...21,365,614
Ensembl chr17:21,348,012...21,368,764

G

malate dehydrogenase 2

increases expression

ISO

tributyltin results in increased expression of MDH2 mRNA

NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841

G

malic enzyme 2

increases expression

ISO

tributyltin results in increased expression of ME2 mRNA

NCBI chr18:69,626,073...69,676,218
Ensembl chr18:69,626,087...69,676,218

G

malic enzyme 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ME3 mRNA

NCBI chr 1:152,946,595...153,148,026
Ensembl chr 1:152,946,628...153,148,026

G

mediator complex subunit 12L

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MED12L mRNA

NCBI chr 2:145,403,318...145,726,317
Ensembl chr 2:145,404,375...145,723,516

G

mediator complex subunit 13

increases expression

EXP

tributyltin results in increased expression of MED13 mRNA

NCBI chr10:71,584,354...71,674,614
Ensembl chr10:71,584,354...71,673,901

G

mediator complex subunit 18

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MED18 mRNA

NCBI chr 5:149,947,345...149,952,672
Ensembl chr 5:149,946,908...149,952,808

G

mediator complex subunit 29

decreases expression

EXP

tributyltin results in decreased expression of MED29 mRNA

NCBI chr 1:92,805,505...92,810,908

G

mesenchyme homeobox 1

increases expression

EXP

tributyltin results in increased expression of MEOX1 mRNA

NCBI chr10:87,318,668...87,338,169
Ensembl chr10:87,318,695...87,337,976

G

meprin A subunit beta

increases expression

ISO

tributyltin results in increased expression of MEP1B mRNA

NCBI chr18:12,641,041...12,667,759
Ensembl chr18:12,641,041...12,667,755

G

mesoderm posterior bHLH transcription factor 1

decreases expression

EXP

tributyltin results in decreased expression of MESP1 mRNA

NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:143,147,671...143,149,189

G

methyltransferase 1, tRNA methylguanosine

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of METTL1 mRNA

NCBI chr 7:64,750,189...64,754,531
Ensembl chr 7:64,750,198...64,754,639

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

increases expression

ISO

tributyltin results in increased expression of MGAT4A mRNA

NCBI chr 9:47,169,229...47,282,577
Ensembl chr 9:47,169,232...47,282,574

G

monoglyceride lipase

increases expression

EXP

tributyltin results in increased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

MIB E3 ubiquitin protein ligase 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MIB1 mRNA

NCBI chr18:2,075,309...2,199,774
Ensembl chr18:2,075,309...2,193,475

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

ISO

tributyltin results in increased expression of MICAL1 mRNA

NCBI chr20:46,547,983...46,568,487
Ensembl chr20:46,556,536...46,568,487

G

MHC class I polypeptide-related sequence B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MICB mRNA

NCBI chr 1:87,623,826...87,641,075
Ensembl chr 1:87,623,826...87,640,872

G

mitotic spindle positioning

increases expression

ISO

tributyltin results in increased expression of MISP mRNA

NCBI chr 7:10,526,980...10,537,159
Ensembl chr 7:10,503,209...10,537,159

G

marker of proliferation Ki-67

multiple interactions
decreases expression

EXP

Fatty Acids, Omega-3 inhibits the reaction [tributyltin results in decreased expression of MKI67 protein]

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

membrane metallo-endopeptidase

increases expression

ISO

tributyltin results in increased expression of MME mRNA

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463

G

matrix metallopeptidase 12

decreases expression

ISO

tributyltin results in decreased expression of MMP12 mRNA

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478

G

matrix metallopeptidase 13

increases expression

ISO

tributyltin results in increased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

increases expression

EXP

tributyltin results in increased expression of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 8

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MMP8 mRNA

NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:13,008,890...13,018,729

G

matrix metallopeptidase 9

multiple interactions

ISO

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP9 mRNA]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

monoacylglycerol O-acyltransferase 2

increases expression

ISO

tributyltin results in increased expression of MOGAT2 mRNA

NCBI chr 1:162,933,964...162,957,896
Ensembl chr 1:162,933,966...162,957,896

G

monooxygenase, DBH-like 1

decreases expression

ISO

tributyltin results in decreased expression of MOXD1 mRNA

NCBI chr 1:22,894,543...22,984,599
Ensembl chr 1:22,894,543...22,984,223

G

mitochondrial pyruvate carrier 2

increases expression

ISO

tributyltin results in increased expression of MPC2 mRNA

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:80,259,727...80,280,668

G

myeloperoxidase

increases activity

EXP

tributyltin results in increased activity of MPO protein

PMID:28161095 PMID:29908848 PMID:30172001 PMID:38936095

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallophosphoesterase 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MPPE1 mRNA

NCBI chr18:63,033,329...63,051,461
Ensembl chr18:63,027,281...63,051,461

G

MPV17 mitochondrial inner membrane protein like

increases expression
multiple interactions

EXP

tributyltin results in increased expression of MPV17L mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of MPV17L mRNA

NCBI chr10:2,495,605...2,532,448
Ensembl chr10:2,495,607...2,532,448

G

melanocortin 2 receptor accessory protein

increases expression

ISO

tributyltin results in increased expression of MRAP mRNA

NCBI chr11:43,477,382...43,489,118
Ensembl chr11:43,478,001...43,489,118

G

mitochondrial ribosomal protein L18

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MRPL18 mRNA

NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:50,384,367...50,389,763

G

mitochondrial ribosomal protein L33

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MRPL33 mRNA

NCBI chr 6:30,545,794...30,553,987
Ensembl chr 6:30,545,794...30,553,987

G

mitochondrial ribosomal protein S33

increases expression
multiple interactions

EXP

tributyltin results in increased expression of MRPS33 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of MRPS33 mRNA

NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:69,563,503...69,572,177

G

membrane spanning 4-domains A8

increases expression

ISO

tributyltin results in increased expression of MS4A8A mRNA

NCBI chr 1:217,155,557...217,169,151
Ensembl chr 1:217,155,557...217,169,215

G

macrophage stimulating 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MST1 mRNA

NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:117,647,438...117,652,015

G

msh homeobox 1

multiple interactions
decreases expression

ISO

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of MSX1 mRNA]

NCBI chr14:77,185,802...77,189,735
Ensembl chr14:77,185,802...77,189,735

G

mitochondrially encoded ATP synthase membrane subunit 6

increases response to substance

ISO

ATP6 gene mutant form results in increased susceptibility to tributyltin

NCBI chr MT:7,919...8,599
Ensembl chr MT:7,904...8,584

G

mitochondrially encoded ATP synthase membrane subunit 8

decreases expression

ISO

tributyltin results in decreased expression of ATP8 mRNA

NCBI chr MT:7,758...7,961
Ensembl chr MT:7,743...7,946

G

metallothionein 1A

decreases expression

ISO

tributyltin results in decreased expression of MT1 mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

decreases expression

ISO

tributyltin results in decreased expression of MT2 mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

methylenetetrahydrofolate reductase

decreases expression

ISO

tributyltin results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

melatonin receptor 1A

decreases expression

ISO

tributyltin results in decreased expression of MTNR1A mRNA

NCBI chr16:53,876,964...53,896,421
Ensembl chr16:53,876,964...53,896,421

G

mechanistic target of rapamycin kinase

decreases phosphorylation
decreases expression

EXP

tributyltin results in decreased phosphorylation of MTOR protein
tributyltin results in decreased expression of MTOR

PMID:20371977 PMID:26961604

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

myotrophin

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MTPN mRNA

NCBI chr 4:65,126,390...65,153,803
Ensembl chr 4:65,115,980...65,153,924

G

microsomal triglyceride transfer protein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MTTP mRNA

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650

G

max dimerization protein 1

increases expression

ISO

tributyltin results in increased expression of MXD1 mRNA

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129

G

Max dimerization protein 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of MXD4 mRNA

NCBI chr14:80,786,768...80,800,790
Ensembl chr14:80,786,342...80,800,788

G

MYD88, innate immune signal transduction adaptor

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of MYD88 mRNA

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

myosin XVB

increases expression

ISO

tributyltin results in increased expression of MYO15B mRNA

NCBI chr10:101,587,672...101,625,092
Ensembl chr10:101,587,672...101,625,092

G

myosin VC

increases expression

ISO

tributyltin results in increased expression of MYO5C mRNA

NCBI chr 8:84,870,031...84,946,996
Ensembl chr 8:84,870,043...84,946,996

G

myosin VIIb

increases expression

ISO

tributyltin results in increased expression of MYO7B mRNA

NCBI chr18:23,862,533...23,944,081
Ensembl chr18:23,862,533...23,944,049

G

nascent polypeptide associated complex subunit alpha

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NACA mRNA

NCBI chr 7:1,053,474...1,066,606
Ensembl chr 7:1,054,338...1,066,605

G

N-acetyl-alpha-glucosaminidase

increases activity

EXP

tributyltin results in increased activity of NAGLU protein

NCBI chr10:86,501,864...86,509,333
Ensembl chr10:86,501,836...86,509,315

G

nicotinamide phosphoribosyltransferase

increases expression

ISO

tributyltin results in increased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

N-acetyltransferase 8 (GCN5-related) family member 5

decreases expression

EXP

tributyltin results in decreased expression of NAT8F5 mRNA

NCBI chr 4:119,817,788...119,842,503
Ensembl chr 4:119,816,735...119,863,953

G

neurobeachin-like 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of NBEAL2 mRNA

NCBI chr 8:119,481,608...119,511,997
Ensembl chr 8:119,481,608...119,514,384

G

neural cell adhesion molecule 1

affects localization
multiple interactions

ISO

tributyltin affects the localization of NCAM1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin affects the localization of NCAM1 protein]

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971

G

non-SMC condensin II complex, subunit H2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of NCAPH2 mRNA

NCBI chr 7:122,302,550...122,319,570
Ensembl chr 7:122,300,252...122,319,569

G

nuclear receptor co-repressor 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NCOR1 mRNA

NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350

G

nudE neurodevelopment protein 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NDE1 mRNA

NCBI chr10:1,347,010...1,391,167
Ensembl chr10:1,347,018...1,383,447

G

N-myc downstream regulated 1

increases expression

EXP

tributyltin results in increased expression of NDRG1 mRNA

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913

G

Ndufa4, mitochondrial complex associated

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NDUFA4 mRNA

NCBI chr 4:40,968,391...40,975,559
Ensembl chr 4:40,968,391...40,975,559

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

ISO

tributyltin results in increased expression of NDUFA5 mRNA

NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

NEDD4 like E3 ubiquitin protein ligase

decreases expression

ISO

tributyltin results in decreased expression of NEDD4L mRNA

NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824

G

neurofilament heavy chain

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of NEFH protein]

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

neurofilament medium chain

increases degradation
multiple interactions

ISO

tributyltin results in increased degradation of NEFM protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of NEFM protein]

NCBI chr15:46,535,857...46,541,161
Ensembl chr15:46,535,517...46,541,163

G

nei-like DNA glycosylase 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of NEIL3 mRNA

NCBI chr16:45,091,401...45,151,419
Ensembl chr16:45,092,200...45,151,205

G

neuraminidase 3

decreases expression

ISO

tributyltin results in decreased expression of NEU3 mRNA

NCBI chr 1:163,549,834...163,560,997
Ensembl chr 1:163,549,738...163,561,049

G

neuralized E3 ubiquitin protein ligase 3

increases expression

ISO

tributyltin results in increased expression of NEURL3 mRNA

NCBI chr 9:45,990,373...45,998,470
Ensembl chr 9:45,990,375...45,998,535

G

neurofibromin 1

increases expression

ISO

tributyltin results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases localization
increases expression

EXP
ISO

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]
tributyltin results in increased localization of NFE2L2 protein
PRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]

PMID:24055800 PMID:25895139 PMID:26079211 PMID:28707438 PMID:36858641

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor, interleukin 3 regulated

decreases expression

ISO

tributyltin results in decreased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

nuclear factor kappa B subunit 1

increases expression

EXP

tributyltin results in increased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

affects expression
decreases expression

ISO
EXP

tributyltin affects the expression of NFKBIA mRNA
tributyltin results in decreased expression of NFKBIA protein

PMID:27678064 PMID:30172001

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

neuronal guanine nucleotide exchange factor

increases expression

ISO

tributyltin results in increased expression of NGEF mRNA

NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:95,594,823...95,692,251

G

NIPA-like domain containing 2

increases expression

EXP

tributyltin results in increased expression of NIPAL2 mRNA

NCBI chr 7:67,659,628...67,771,105
Ensembl chr 7:67,659,628...67,769,959

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions
decreases expression

ISO

Tretinoin promotes the reaction [tributyltin results in decreased expression of NME2 protein]

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

nocturnin

increases expression

ISO

tributyltin results in increased expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282

G

nucleolar protein 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NOL4 mRNA

NCBI chr18:14,207,303...14,569,697
Ensembl chr18:14,207,303...14,569,677

G

nitric oxide synthase 1

multiple interactions
decreases activity

EXP

CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]; tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 1 adaptor protein

decreases expression

ISO

tributyltin results in decreased expression of NOS1AP mRNA

NCBI chr13:85,080,558...85,353,741
Ensembl chr13:85,063,350...85,353,741

G

nitric oxide synthase 2

increases expression

EXP

tributyltin results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

decreases expression
multiple interactions

EXP

tributyltin results in decreased expression of NOS3 protein
tributyltin results in decreased expression of and results in increased phosphorylation of NOS3 protein

PMID:26873547 PMID:34902535

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

neuronal PAS domain protein 2

decreases expression

ISO

tributyltin results in decreased expression of NPAS2 mRNA

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

neuropeptide Y

decreases expression

ISO

tributyltin results in decreased expression of NPY protein

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

nuclear receptor subfamily 1, group D, member 1

increases expression

ISO

tributyltin results in increased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 1, group D, member 2

increases expression

ISO

tributyltin results in increased expression of NR1D2 mRNA

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions
increases expression

ISO

tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]
tributyltin results in increased expression of NR1H3 mRNA

PMID:23428407 PMID:24848799 PMID:25932594 PMID:28011154

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

tributyltin binds to and results in increased activity of NR1I2 protein
tributyltin binds to and results in decreased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

ISO

tributyltin results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

EXP

tributyltin results in decreased expression of NR5A1 mRNA; tributyltin results in decreased expression of NR5A1 protein

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

nardilysin convertase

decreases expression

ISO

tributyltin results in decreased expression of NRDC mRNA

NCBI chr 5:128,983,395...129,047,578
Ensembl chr 5:128,984,446...129,050,141

G

neuronal regeneration related protein

increases expression

ISO

tributyltin results in increased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

NSE3 homolog, SMC5-SMC6 complex component

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of NSMCE3 mRNA

NCBI chr 1:127,812,572...127,813,899

G

O-acyltransferase like

decreases expression

EXP

tributyltin results in decreased expression of OACYL mRNA

NCBI chr18:61,482,337...61,533,704
Ensembl chr18:61,482,337...61,533,704

G

2'-5' oligoadenylate synthetase 1D

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OAS1D mRNA

NCBI chr12:41,309,214...41,318,823
Ensembl chr12:41,309,214...41,318,650

G

odontogenic, ameloblast associated

increases expression

EXP

tributyltin results in increased expression of ODAM mRNA

NCBI chr14:20,472,530...20,496,752
Ensembl chr14:20,472,546...20,481,760

G

oxoglutarate dehydrogenase

increases expression

ISO

tributyltin results in increased expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

8-oxoguanine DNA glycosylase

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OGG1 mRNA

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604

G

olfactory receptor 1049

increases expression

EXP

tributyltin results in increased expression of OLR1049 mRNA

NCBI chr 7:6,870,688...6,871,623

G

one cut homeobox 1

increases expression

ISO

tributyltin results in increased expression of ONECUT1 mRNA

NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:84,480,305...84,508,124

G

olfactory receptor family 10 subfamily A member 48B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR10A48 mRNA

NCBI chr 1:172,228,688...172,229,623
Ensembl chr 1:172,228,688...172,229,623

G

olfactory receptor family 10 subfamily D member 1G

decreases expression

EXP

tributyltin results in decreased expression of OR10D1G mRNA

NCBI chr 8:48,040,566...48,047,353
Ensembl chr 8:48,040,878...48,041,813

G

olfactory receptor family 10 subfamily U member 3

increases expression

EXP

tributyltin results in increased expression of OR10U3 mRNA

NCBI chr 7:7,226,661...7,227,623
Ensembl chr 7:7,226,661...7,227,623

G

olfactory receptor family 12 subfamily E member 13B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR12E13B mRNA

NCBI chr 3:93,774,889...93,775,824
Ensembl chr 3:93,774,889...93,775,824

G

olfactory receptor family 13 subfamily C member 3C

decreases expression
multiple interactions

EXP

tributyltin results in decreased expression of OR13C3C mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of OR13C3 mRNA

NCBI chr 5:72,073,839...72,074,792
Ensembl chr 5:72,073,839...72,074,792

G

olfactory receptor family 13 subfamily F member 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR13F5 mRNA

NCBI chr 5:72,037,146...72,038,105
Ensembl chr 5:72,037,146...72,038,105

G

olfactory receptor family 13 subfamily M member 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR13M2 mRNA

NCBI chr 4:72,759,769...72,760,704
Ensembl chr 4:72,759,769...72,760,704

G

olfactory receptor family 14 subfamily J member 3D

decreases expression

EXP

tributyltin results in decreased expression of OR14J3D mRNA

NCBI chr20:878,254...879,168
Ensembl chr20:839,096...852,011

G

olfactory receptor family 1 subfamily AD member 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR1AD1 mRNA

NCBI chr10:35,800,754...35,801,677
Ensembl chr10:35,800,754...35,801,677

G

olfactory receptor family 1 subfamily F member 19F

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR1F19F mRNA

NCBI chr10:12,732,090...12,737,385
Ensembl chr10:12,735,763...12,736,692

G

olfactory receptor family 1 subfamily O member 2B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR1O2B mRNA

NCBI chr20:1,207,099...1,208,028
Ensembl chr20:1,207,099...1,208,028

G

olfactory receptor family 1 subfamily O member 2C

decreases expression

EXP

tributyltin results in decreased expression of OR1O2C mRNA

NCBI chr20:1,078,730...1,079,659
Ensembl chr20:1,078,730...1,079,659

G

olfactory receptor family 2 subfamily T member 26

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR2T26 mRNA

NCBI chr10:33,947,662...33,948,615
Ensembl chr10:33,947,662...33,948,615

G

olfactory receptor family 2 subfamily T member 48D

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR2T48D mRNA

NCBI chr10:43,356,389...43,357,333
Ensembl chr10:43,356,389...43,357,333

G

olfactory receptor family 4 subfamily A member 66C

increases expression

EXP

tributyltin results in increased expression of OR4A66C mRNA

NCBI chr 3:94,888,321...94,889,250

G

olfactory receptor family 4 subfamily C member 108

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR4C108 mRNA

NCBI chr 3:95,226,606...95,228,176

G

olfactory receptor family 4 subfamily F member 14F

decreases expression

EXP

tributyltin results in decreased expression of OR4F14F mRNA

NCBI chr 3:118,987,980...118,988,918
Ensembl chr 3:118,987,980...118,988,918

G

olfactory receptor family 4 subfamily F member 60

decreases expression

EXP

tributyltin results in decreased expression of OR4F60 mRNA

NCBI chr 3:119,430,136...119,431,071
Ensembl chr 3:119,430,136...119,431,071

G

olfactory receptor family 51 subfamily A member 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR51A7 mRNA

NCBI chr 1:166,805,392...166,809,420
Ensembl chr 1:166,807,689...166,808,627

G

olfactory receptor family 51 subfamily F member 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR51F4 mRNA

NCBI chr 1:166,666,225...166,670,094
Ensembl chr 1:166,669,150...166,670,094

G

olfactory receptor family 52 subfamily E member 8B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR52E8B mRNA

NCBI chr 1:168,824,792...168,825,745
Ensembl chr 1:168,824,792...168,825,745

G

olfactory receptor family 52 subfamily N member 2F

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR52N2F mRNA

NCBI chr 1:168,633,755...168,639,299

G

olfactory receptor family 52 subfamily P member 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR52P1 mRNA

NCBI chr 1:168,301,668...168,302,657
Ensembl chr 1:168,257,886...168,338,866

G

olfactory receptor family 56 subfamily A member 3B

multiple interactions
decreases expression

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR56A3B mRNA
tributyltin results in decreased expression of OR56A3B mRNA

NCBI chr 1:168,888,025...168,888,972
Ensembl chr 1:168,888,025...168,888,972

G

olfactory receptor family 5 subfamily AC member 22

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR5AC22 mRNA

NCBI chr11:54,528,372...54,529,289
Ensembl chr11:54,528,372...54,529,289

G

olfactory receptor family 5 subfamily AU member 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5AU1 mRNA

NCBI chr15:27,211,299...27,215,828
Ensembl chr15:27,212,536...27,213,471

G

olfactory receptor family 5 subfamily B member 124

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5B124 mRNA

NCBI chr 1:220,156,509...220,157,450
Ensembl chr 1:220,156,509...220,157,450

G

olfactory receptor family 5 subfamily G member 27B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR5G27B mRNA

NCBI chr 3:91,076,694...91,077,638
Ensembl chr 3:91,076,694...91,077,638

G

olfactory receptor family 5 subfamily H member 26B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR5H26B mRNA

NCBI chr11:54,711,384...54,712,313
Ensembl chr11:54,711,384...54,712,313

G

olfactory receptor family 5 subfamily P member 60B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5P60B mRNA

NCBI chr 1:171,586,032...171,586,997
Ensembl chr 1:171,586,032...171,586,997

G

olfactory receptor family 5 subfamily T member 5B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5T5B mRNA

NCBI chr 3:92,209,945...92,210,913
Ensembl chr 3:92,209,945...92,210,913

G

olfactory receptor family 5 subfamily W member 15

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5W15 mRNA

NCBI chr 3:93,665,866...93,666,804
Ensembl chr 3:93,665,866...93,666,804

G

olfactory receptor family 6 subfamily C member 35F

decreases expression

EXP

tributyltin results in decreased expression of OR6C35F mRNA

NCBI chr 7:3,182,446...3,183,390
Ensembl chr 7:3,182,446...3,183,390

G

olfactory receptor family 6 subfamily D member 13B

decreases expression

EXP

tributyltin results in decreased expression of OR6D13B mRNA

NCBI chr 4:151,346,015...151,346,998
Ensembl chr 4:151,346,015...151,346,998

G

olfactory receptor family 6 subfamily F member 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of OR6F1 mRNA

NCBI chr 1:149,301,451...149,302,377
Ensembl chr 1:149,301,451...149,302,377

G

olfactory receptor family 6 subfamily F member 2

decreases expression

EXP

tributyltin results in decreased expression of OR6F2 mRNA

NCBI chr 1:204,406,568...204,407,503
Ensembl chr 1:204,406,550...204,407,503

G

olfactory receptor family 7 subfamily A member 38E

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR7A38E mRNA

NCBI chr 7:11,436,501...11,437,433
Ensembl chr 7:11,436,501...11,437,433

G

olfactory receptor family 7 subfamily A member 39

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR7A39 mRNA

NCBI chr 7:11,394,540...11,395,472
Ensembl chr 7:11,394,540...11,395,472

G

olfactory receptor family 7 subfamily E member 171

decreases expression

EXP

tributyltin results in decreased expression of OR7E171 mRNA

NCBI chr 8:26,230,250...26,231,179
Ensembl chr 8:26,230,250...26,231,179

G

olfactory receptor family 7 subfamily G member 35

increases expression

EXP

tributyltin results in increased expression of OR7G35 mRNA

NCBI chr 8:25,811,081...25,812,019
Ensembl chr 8:25,811,081...25,812,019

G

olfactory receptor family 8 subfamily B member 101B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OR8B101B mRNA

NCBI chr 8:45,947,013...45,947,960
Ensembl chr 8:45,947,013...45,947,960

G

olfactory receptor family 9 subfamily I member 2

decreases expression

EXP

tributyltin results in decreased expression of OR9I2 mRNA

NCBI chr 1:220,475,202...220,476,149
Ensembl chr 1:220,475,202...220,476,149

G

oxysterol binding protein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of OSBP mRNA

NCBI chr 1:218,313,455...218,343,263
Ensembl chr 1:218,313,148...218,343,258

G

oxysterol binding protein-like 3

multiple interactions
increases expression

EXP
ISO

[bisphenol A co-treated with tributyltin] results in increased expression of OSBPL3 mRNA
tributyltin results in increased expression of OSBPL3 mRNA

PMID:31129395 PMID:31939706

NCBI chr 4:80,677,383...80,854,169
Ensembl chr 4:80,677,390...80,854,169

G

oxidative stress induced growth inhibitor family member 2

decreases expression
multiple interactions

EXP

tributyltin results in decreased expression of OSGIN2 mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of OSGIN2 mRNA

NCBI chr 5:34,297,417...34,316,353
Ensembl chr 5:34,297,417...34,316,931

G

orthodenticle homeobox 2

increases expression

EXP

tributyltin results in increased expression of OTX2 mRNA

NCBI chr15:24,422,876...24,432,709
Ensembl chr15:24,422,876...24,432,472

G

3-oxoacid CoA transferase 1

increases expression

ISO

tributyltin results in increased expression of OXCT1 mRNA

NCBI chr 2:54,963,964...55,112,303
Ensembl chr 2:54,963,784...55,112,298

G

P2Y receptor family member 10

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of P2RY10 mRNA

NCBI chr X:76,184,064...76,279,996
Ensembl chr X:76,184,001...76,280,953

G

prolyl 4-hydroxylase subunit alpha 3

increases expression

EXP

tributyltin results in increased expression of P4HA3 mRNA

NCBI chr 1:164,040,852...164,075,922
Ensembl chr 1:164,040,864...164,076,435

G

proton activated chloride channel 1

increases expression

ISO

tributyltin results in increased expression of PACC1 mRNA

NCBI chr13:105,435,772...105,460,877
Ensembl chr13:105,435,799...105,461,095

G

pantothenate kinase 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PANK4 mRNA

NCBI chr 5:170,807,744...170,824,478
Ensembl chr 5:170,807,745...170,824,477

G

progestin and adipoQ receptor family member 4

increases expression

ISO

tributyltin results in increased expression of PAQR4 mRNA

NCBI chr10:13,263,559...13,267,237
Ensembl chr10:13,263,559...13,267,173

G

par-6 family cell polarity regulator beta

increases expression

ISO

tributyltin results in increased expression of PARD6B mRNA

NCBI chr 3:177,209,429...177,230,509
Ensembl chr 3:177,209,258...177,230,510

G

prostate androgen-regulated mucin-like protein 1

increases expression

ISO

tributyltin results in increased expression of PARM1 mRNA

NCBI chr14:16,752,541...16,861,570
Ensembl chr14:16,752,541...16,881,138

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

EXP
ISO

[bisphenol A co-treated with tributyltin] results in increased expression of PARP1 mRNA
tributyltin results in increased cleavage of PARP1 protein
DFFB protein promotes the reaction [tributyltin results in increased cleavage of PARP1 protein]

PMID:31129395 PMID:31401084

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

prostate and testis expressed 4

decreases expression

EXP

tributyltin results in decreased expression of PATE4 mRNA

NCBI chr 8:42,246,492...42,249,233
Ensembl chr 8:42,246,978...42,249,234

G

pyruvate carboxylase

increases expression

ISO

tributyltin results in increased expression of PCX mRNA

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

phosphoenolpyruvate carboxykinase 1

increases expression

ISO

tributyltin results in increased expression of PCK1 mRNA

PMID:23428407 PMID:24848799

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

ISO

tributyltin results in increased expression of PCK2 protein

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PCMTD2 mRNA

NCBI chr 3:189,337,758...189,360,525
Ensembl chr 3:189,337,816...189,357,001

G

proprotein convertase subtilisin/kexin type 1 inhibitor

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PCSK1N mRNA

NCBI chr X:17,251,963...17,255,405
Ensembl chr X:17,251,965...17,257,360

G

proprotein convertase subtilisin/kexin type 4

increases expression

ISO

tributyltin results in increased expression of PCSK4 mRNA

NCBI chr 7:10,032,040...10,040,263
Ensembl chr 7:10,031,988...10,040,255

G

prenylcysteine oxidase 1

increases expression

ISO

tributyltin results in increased expression of PCYOX1 mRNA

NCBI chr 4:120,389,545...120,400,382
Ensembl chr 4:120,388,180...120,400,382

G

programmed cell death 5 like 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PDCD5L1 mRNA

NCBI chr 3:84,051,611...84,053,009
Ensembl chr 3:84,051,353...84,074,715

G

programmed cell death 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PDCD7 mRNA

NCBI chr 8:74,757,768...74,772,495
Ensembl chr 8:74,757,768...74,781,634

G

phosphodiesterase 4D

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PDE4D mRNA

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569

G

pyruvate dehydrogenase E1 subunit beta

increases expression

ISO

tributyltin results in increased expression of PDHB mRNA

NCBI chr15:19,182,789...19,188,731
Ensembl chr15:19,181,208...19,188,976

G

pyruvate dehydrogenase kinase 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PDK2 mRNA

NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355

G

pyruvate dehydrogenase kinase 4

decreases expression

ISO

tributyltin results in decreased expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDS5 cohesin associated factor A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PDS5A mRNA

NCBI chr14:42,905,734...43,004,740
Ensembl chr14:42,905,328...43,004,740

G

PDS5 cohesin associated factor B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PDS5B mRNA

NCBI chr12:5,038,114...5,181,208
Ensembl chr12:5,038,160...5,181,208

G

pancreatic and duodenal homeobox 1

multiple interactions
decreases expression

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PDX1 mRNA
tributyltin results in decreased expression of PDX1 mRNA

PMID:31129395 PMID:35563431

NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156

G

period circadian regulator 2

increases expression

ISO

tributyltin results in increased expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

period circadian regulator 3

increases expression

ISO

tributyltin results in increased expression of PER3 mRNA

NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:166,743,050...166,777,999

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression

ISO

tributyltin results in increased expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

phosphoglucomutase 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PGM3 mRNA

NCBI chr 8:96,398,331...96,416,045
Ensembl chr 8:96,398,269...96,416,021

G

progesterone receptor

increases expression

EXP
ISO

tributyltin results in increased expression of PGR protein
tributyltin results in increased expression of PGR mRNA

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphate regulating endopeptidase X-linked

multiple interactions

ISO

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PHEX mRNA]

NCBI chr X:41,422,561...41,671,226
Ensembl chr X:41,426,101...41,671,226

G

phosphatidylinositol glycan anchor biosynthesis, class A

increases expression

EXP

tributyltin results in increased expression of PIGA mRNA

NCBI chr X:33,672,832...33,687,747
Ensembl chr X:33,674,923...33,687,636

G

phosphatidylinositol glycan anchor biosynthesis, class O

decreases expression

EXP

tributyltin results in decreased expression of PIGO mRNA

NCBI chr 5:62,040,979...62,052,067
Ensembl chr 5:62,037,308...62,052,075

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases expression
decreases expression

ISO

tributyltin results in increased expression of PIK3CA mRNA
tributyltin results in decreased expression of PIK3CA mRNA

PMID:26314263 PMID:27678064

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

increases expression

ISO

tributyltin results in increased expression of PIK3CB mRNA

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

increases expression

ISO

tributyltin results in increased expression of PIK3CG mRNA

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509

G

paired-like homeodomain 3

decreases expression

ISO

tributyltin results in decreased expression of PITX3 mRNA

NCBI chr 1:254,942,550...254,955,325
Ensembl chr 1:254,942,608...254,955,336

G

pyruvate kinase M1/2

increases expression

ISO

tributyltin results in increased expression of PKM mRNA

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

plakophilin 3

increases expression

ISO

tributyltin results in increased expression of PKP3 mRNA

NCBI chr 1:205,617,511...205,628,441
Ensembl chr 1:205,617,511...205,628,440

G

placenta associated 8

increases expression

ISO

tributyltin results in increased expression of PLAC8 mRNA

NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,356,972...9,378,572

G

phospholipase C, beta 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PLCB4 mRNA

NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113

G

phospholipase C, epsilon 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PLCE1 mRNA

NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:245,657,080...245,963,828

G

phospholipase C, gamma 1

decreases expression

ISO

tributyltin results in decreased expression of PLCG1 mRNA

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

phospholipase C, gamma 2

decreases expression

ISO

tributyltin results in decreased expression of PLCG2 mRNA

NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684

G

phospholipase D family, member 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PLD3 mRNA

NCBI chr 1:91,949,465...91,971,834
Ensembl chr 1:91,949,467...91,961,207

G

pleckstrin homology, MyTH4 and FERM domain containing H1

increases expression

ISO

tributyltin results in increased expression of PLEKHH1 mRNA

NCBI chr 6:103,572,304...103,621,729
Ensembl chr 6:103,572,291...103,621,728

G

perilipin 1

increases expression
multiple interactions

ISO

tributyltin results in increased expression of PLIN1 mRNA
[tributyltin co-treated with LHB protein] results in increased expression of PLIN1 mRNA

PMID:23428407 PMID:25777084 PMID:25932594 PMID:30027469 PMID:38630605

NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206

G

perilipin 2

increases expression

ISO

tributyltin results in increased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

proteolipid protein 2

increases expression

EXP

tributyltin results in increased expression of PLP2 mRNA

NCBI chr X:17,506,153...17,509,552
Ensembl chr X:17,506,059...17,509,550

G

phospholipid phosphatase 1

decreases expression

ISO

tributyltin results in decreased expression of PPAP2A mRNA

NCBI chr 2:46,172,202...46,233,632
Ensembl chr 2:46,172,197...46,234,676

G

plastin 1

increases expression

ISO

tributyltin results in increased expression of PLS1 mRNA

NCBI chr 8:105,196,312...105,306,252
Ensembl chr 8:105,197,455...105,292,447

G

plexin domain containing 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PLXDC2 mRNA

NCBI chr17:84,077,793...84,502,831
Ensembl chr17:84,104,864...84,497,999

G

PNKD metallo-beta-lactamase domain containing

decreases expression

EXP

tributyltin results in decreased expression of PNKD mRNA

NCBI chr 9:83,317,757...83,386,263
Ensembl chr 9:83,317,738...83,386,262

G

PARN like ribonuclease domain containing exonuclease 1

increases expression

ISO

tributyltin results in increased expression of PNLDC1 mRNA

NCBI chr 1:50,390,884...50,409,457
Ensembl chr 1:50,390,918...50,409,457

G

PNMA family member 8A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PNMA8A mRNA

NCBI chr 1:86,763,475...86,771,117
Ensembl chr 1:86,756,168...86,815,182

G

patatin-like phospholipase domain containing 2

multiple interactions

ISO

[tributyltin co-treated with LHB protein] results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

patatin-like phospholipase domain containing 8

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PNPLA8 mRNA

NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:67,056,697...67,120,512

G

POC1 centriolar protein B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of POC1B mRNA

NCBI chr 7:35,810,761...35,912,571
Ensembl chr 7:35,810,820...35,912,571

G

cytochrome p450 oxidoreductase

increases expression

ISO

tributyltin results in increased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

POU domain class 5, transcription factor 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of POU5F2 mRNA

NCBI chr 2:9,643,313...9,644,547

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

tributyltin results in increased expression of PPARA mRNA

PMID:23322813 PMID:30027469

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

increases expression
affects expression
multiple interactions
increases activity
affects binding

ISO
EXP

tributyltin results in increased expression of PPARG mRNA; tributyltin results in increased expression of PPARG protein
tributyltin affects the expression of PPARG mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of PPARG protein
tributyltin results in increased activity of PPARG protein
tributyltin binds to PPARG protein
T 0070907 inhibits the reaction [tributyltin results in increased expression of PPARG mRNA]; tributyltin binds to and results in increased activity of PPARG protein; tributyltin inhibits the reaction [GW 1929 binds to PPARG protein]; tributyltin inhibits the reaction [Rosiglitazone binds to PPARG protein]; tributyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]
[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of PPARG protein; PPARG protein promotes the reaction [tributyltin binds to and results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [tributyltin binds to and results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [tributyltin results in increased expression of PPARG mRNA]; tributyltin binds to and results in increased activity of PPARG protein; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]

PMID:19497422 PMID:21622945 PMID:22197818 PMID:23322813 PMID:24155963 More...

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

pro-platelet basic protein

decreases expression

EXP
ISO

tributyltin results in decreased expression of PPBP mRNA

PMID:31129395 PMID:31939706

NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

increases expression

EXP

tributyltin results in increased expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

ISO

tributyltin results in decreased expression of PPP1R3C mRNA

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835

G

protein phosphatase 1, regulatory subunit 8

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PPP1R8 mRNA

NCBI chr 5:150,315,607...150,332,726
Ensembl chr 5:150,315,494...150,332,726

G

protein phosphatase 2, regulatory subunit B', alpha

increases expression

ISO

tributyltin results in increased expression of PPP2R5A mRNA

NCBI chr13:105,462,371...105,506,767
Ensembl chr13:105,462,371...105,506,767

G

protein phosphatase 4, regulatory subunit 3A

increases expression

EXP

tributyltin results in increased expression of PPP4R3A mRNA

NCBI chr 6:126,032,068...126,098,329
Ensembl chr 6:126,032,068...126,095,543

G

peptidylprolyl isomerase domain and WD repeat containing 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PPWD1 mRNA

NCBI chr 2:37,069,744...37,094,252
Ensembl chr 2:37,071,083...37,094,242

G

PRAME family member 20

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PRAMEF20 mRNA

NCBI chr 5:161,454,398...161,458,874
Ensembl chr 5:161,453,893...161,459,073

G

PR/SET domain 16

affects methylation
increases expression

ISO

tributyltin affects the methylation of PRDM16 gene
tributyltin results in increased expression of PRDM16 mRNA

PMID:28011154 PMID:31939706

NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:170,162,275...170,485,804

G

protein kinase C, alpha

decreases expression

ISO

tributyltin results in decreased expression of PRKCA mRNA

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

increases expression

ISO

tributyltin results in increased expression of PRKCB mRNA

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, delta

multiple interactions
decreases response to substance

ISO

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BAD protein modified form]; PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2L1 protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of BAX protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; PRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]; PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]; PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA]
PRKCD gene mutant form results in decreased susceptibility to tributyltin

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase D1

increases phosphorylation

ISO

tributyltin results in increased phosphorylation of PRKD1 protein

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

protein kinase D3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PRKD3 mRNA

NCBI chr 6:21,784,665...21,860,600
Ensembl chr 6:21,784,673...21,860,600

G

protein C, inactivator of coagulation factors Va and VIIIa

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PROC mRNA

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

prominin 1

increases expression

ISO

tributyltin results in increased expression of PROM1 mRNA

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

proline rich 11

increases expression

ISO

tributyltin results in increased expression of PRR11 mRNA

NCBI chr10:72,396,127...72,440,643
Ensembl chr10:72,398,667...72,418,275

G

proline rich 15-like

increases expression

ISO

tributyltin results in increased expression of PRR15L mRNA

NCBI chr10:82,412,934...82,418,897
Ensembl chr10:82,402,733...82,419,558

G

proline rich 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PRR4 mRNA

NCBI chr 4:168,336,501...168,340,300
Ensembl chr 4:168,275,146...168,338,983

G

proline rich and Gla domain 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PRRG3 mRNA

NCBI chr X:154,711,246...154,731,359
Ensembl chr X:154,712,625...154,722,831

G

peroxiredoxin like 2A

increases expression

ISO

tributyltin results in increased expression of PRXL2A mRNA

NCBI chr16:16,900,697...16,920,521
Ensembl chr16:16,900,699...16,920,561

G

proteasome assembly chaperone 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of PSMG3 mRNA

NCBI chr12:19,923,288...19,926,205
Ensembl chr12:19,923,288...19,926,205

G

phosphatase and tensin homolog

increases expression

ISO

tributyltin results in increased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin reductase 1

increases expression

ISO

tributyltin results in increased expression of PTGR1 mRNA

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO
EXP

tributyltin results in increased expression of PTGS2 mRNA
tributyltin results in increased expression of PTGS2 protein

PMID:19371601 PMID:23743147

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 11

increases expression

ISO

tributyltin results in increased expression of PTPN11 mRNA

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577

G

protein tyrosine phosphatase, receptor type, N

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PTPRN mRNA

NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:84,189,676...84,204,850

G

protein tyrosine phosphatase, receptor type, T

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of PTPRT mRNA

NCBI chr 3:170,608,993...171,707,692
Ensembl chr 3:170,608,993...171,746,088

G

peroxisomal membrane protein 4

decreases expression

ISO

tributyltin results in decreased expression of PXMP4 mRNA

NCBI chr 3:163,553,582...163,570,829
Ensembl chr 3:163,553,599...163,570,829

G

PYD and CARD domain containing

increases expression

ISO

tributyltin results in increased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

RAB24, member RAS oncogene family

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RAB24 mRNA

NCBI chr17:9,313,593...9,315,675
Ensembl chr17:9,313,593...9,316,575

G

RAB25, member RAS oncogene family

increases expression

ISO

tributyltin results in increased expression of RAB25 mRNA

NCBI chr 2:176,298,124...176,304,221
Ensembl chr 2:176,298,124...176,304,221

G

RAB37, member RAS oncogene family

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of RAB37 mRNA

NCBI chr10:100,833,240...100,900,950
Ensembl chr10:100,833,397...100,900,944

G

RAB3B, member RAS oncogene family

increases expression

EXP

tributyltin results in increased expression of RAB3B mRNA

NCBI chr 5:128,859,034...128,926,087
Ensembl chr 5:128,841,716...128,926,086

G

RAD18 E3 ubiquitin protein ligase

increases expression

EXP

tributyltin results in increased expression of RAD18 mRNA

NCBI chr 4:147,291,463...147,376,904
Ensembl chr 4:147,291,276...147,376,869

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

tributyltin affects the expression of and results in increased phosphorylation of RAF1 protein

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

retinoic acid receptor, beta

increases expression

ISO

tributyltin results in increased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040

G

retinoic acid receptor, gamma

increases expression
multiple interactions

EXP
ISO

tributyltin results in increased expression of RARG mRNA
tributyltin results in increased activity of [RARG protein binds to RXRA protein]

PMID:21683754 PMID:30639747

NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:135,246,427...135,268,889

G

retinoic acid receptor responder 2

increases expression

ISO

tributyltin results in increased expression of RARRES2 mRNA

NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457

G

RAS protein activator like 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RASAL2 mRNA

NCBI chr13:71,808,740...72,102,723
Ensembl chr13:71,813,261...72,102,723

G

ras related dexamethasone induced 1

increases expression
multiple interactions

EXP

tributyltin results in increased expression of RASD1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RAS guanyl releasing protein 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RASGRP1 mRNA

NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434

G

Ras association domain family member 5

increases expression

ISO

tributyltin results in increased expression of RASSF5 mRNA

NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277

G

RB binding protein 6, ubiquitin ligase

increases expression

EXP

tributyltin results in increased expression of RBBP6 mRNA

NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852

G

RNA binding protein, mRNA processing factor

increases expression

ISO

tributyltin results in increased expression of RBPMS mRNA

NCBI chr16:64,942,159...65,098,504
Ensembl chr16:64,942,530...65,098,503

G

receptor accessory protein 6

increases expression

ISO

tributyltin results in increased expression of REEP6 mRNA

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:10,024,602...10,031,740

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation
increases expression

EXP
ISO

Phycocyanin inhibits the reaction [tributyltin results in increased expression of RELA protein]
tributyltin results in increased phosphorylation of RELA protein

PMID:23743147 PMID:26079211 PMID:30172001 PMID:36319700

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

resistin

increases expression

ISO

tributyltin results in increased expression of RETN mRNA

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116

G

retinol saturase

increases expression

ISO

tributyltin results in increased expression of RETSAT mRNA

NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:106,211,436...106,229,552

G

refilin B

increases expression

ISO

tributyltin results in increased expression of RFLNB mRNA

NCBI chr10:61,391,947...61,398,224
Ensembl chr10:61,390,659...61,398,224

G

regulatory factor X8

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RFX8 mRNA

NCBI chr 9:49,453,282...49,517,123
Ensembl chr 9:49,453,289...49,515,134

G

regulator of G-protein signaling 3

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RGS3 mRNA
tributyltin results in increased expression of RGS3 mRNA

NCBI chr 5:81,037,588...81,177,446
Ensembl chr 5:81,056,068...81,177,445

G

RIC3 acetylcholine receptor chaperone

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of RIC3 mRNA

NCBI chr 1:172,465,638...172,521,349
Ensembl chr 1:172,466,991...172,521,349

G

ribosomal modification protein rimK-like family member B

increases expression

EXP

tributyltin results in increased expression of RIMKLB mRNA

NCBI chr 4:157,336,950...157,396,970
Ensembl chr 4:157,344,414...157,378,727

G

RBPJ interacting and tubulin associated 1

decreases expression

EXP

tributyltin results in decreased expression of RITA1 mRNA

NCBI chr12:41,610,713...41,614,545
Ensembl chr12:41,610,877...41,614,541

G

relaxin 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RLN1 mRNA

NCBI chr 1:236,493,532...236,496,541
Ensembl chr 1:236,493,536...236,496,440

G

ring finger protein 115

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RNF115 mRNA

NCBI chr 2:186,950,959...187,018,673
Ensembl chr 2:186,950,760...187,019,561

G

ring finger protein 144A

decreases expression

ISO

tributyltin results in decreased expression of RNF144A mRNA

NCBI chr 6:48,628,241...48,748,241
Ensembl chr 6:48,631,648...48,748,179

G

ring finger protein 20

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RNF20 mRNA

NCBI chr 5:68,771,507...68,797,240
Ensembl chr 5:68,771,535...68,797,240

G

ring finger protein 212

increases expression

EXP

tributyltin results in increased expression of RNF212 mRNA

NCBI chr14:1,090,752...1,132,242
Ensembl chr14:1,093,759...1,169,966

G

ring finger protein 39

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RNF39 mRNA

NCBI chr20:1,610,027...1,615,516
Ensembl chr20:1,610,026...1,612,323

G

roundabout guidance receptor 2

increases expression

EXP

tributyltin results in increased expression of ROBO2 mRNA

NCBI chr11:26,015,919...27,583,750
Ensembl chr11:26,015,919...26,876,185

G

Rho-associated coiled-coil containing protein kinase 1

increases expression

ISO

tributyltin results in increased expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

ISO

tributyltin results in increased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

ribosomal protein S6

affects expression

ISO

tributyltin affects the expression of RPS6 protein

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S6 kinase A3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of RPS6KA3 mRNA

NCBI chr X:39,325,926...39,432,017
Ensembl chr X:39,325,926...39,433,678

G

RNA pseudouridine synthase domain containing 2

increases expression

EXP

tributyltin results in increased expression of RPUSD2 mRNA

NCBI chr 3:126,471,620...126,476,869
Ensembl chr 3:126,471,579...126,477,180

G

ribonucleotide reductase catalytic subunit M1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:166,235,900...166,260,944

G

ribosomal RNA processing 12

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of RRP12 mRNA

NCBI chr 1:250,621,707...250,655,318
Ensembl chr 1:250,621,707...250,655,318

G

remodeling and spacing factor 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RSF1 mRNA

NCBI chr 1:161,303,596...161,426,326
Ensembl chr 1:161,303,660...161,420,290

G

arginine and serine rich coiled-coil 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of RSRC1 mRNA

NCBI chr 2:153,536,839...153,942,825
Ensembl chr 2:153,541,161...153,942,824

G

RT1 class I, locus CE5

increases expression

EXP

tributyltin results in increased expression of RT1-CE5 mRNA

NCBI chr20:3,407,880...3,484,130

G

RT1 class I, locus M1, gene 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of RT1-M1-2 mRNA

NCBI chr20:1,914,719...1,919,577
Ensembl chr20:1,914,873...1,918,636

G

RNA transcription, translation and transport factor

increases expression

EXP

tributyltin results in increased expression of RTRAF mRNA

NCBI chr15:4,482,699...4,507,115
Ensembl chr15:4,480,966...4,507,115

G

RUNX family transcription factor 2

decreases expression

ISO

tributyltin results in decreased expression of RUNX2 mRNA

PMID:23322813 PMID:24513447 PMID:25777084 PMID:25932594

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

retinoid X receptor alpha

multiple interactions
decreases response to substance
increases expression
increases activity

ISO
EXP

[tributyltin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; RXRA protein affects the reaction [tributyltin results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 protein]; tributyltin inhibits the reaction [Alitretinoin binds to RXRA protein]; tributyltin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; tributyltin results in increased activity of [RARG protein binds to RXRA protein]
RXRA protein mutant form results in decreased susceptibility to tributyltin
tributyltin results in increased expression of RXRA protein
[bisphenol A co-treated with tributyltin] results in increased expression of RXRA protein
tributyltin results in increased expression of RXRA mRNA
tributyltin results in increased activity of RXRA protein

PMID:15941851 PMID:27131391 PMID:29787037 PMID:30027469 PMID:30639747 More...

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

retinoid X receptor beta

increases expression
multiple interactions

EXP

tributyltin results in increased expression of RXRB protein
[bisphenol A co-treated with tributyltin] results in increased expression of RXRB protein

NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359

G

retinoid X receptor gamma

increases expression
multiple interactions

ISO
EXP

tributyltin results in increased expression of RXRG mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of RXRG protein
tributyltin results in increased expression of RXRG protein

PMID:23428407 PMID:24848799 PMID:30027469 PMID:31129395

NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095

G

S100 calcium binding protein A6

increases expression

EXP

tributyltin results in increased expression of S100A6 mRNA

NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762

G

S100 calcium binding protein A8

increases expression

ISO

tributyltin results in increased expression of S100A8 mRNA

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

spalt-like transcription factor 2

increases expression

EXP

tributyltin results in increased expression of SALL2 mRNA

NCBI chr15:27,494,831...27,512,402
Ensembl chr15:27,494,589...27,512,402

G

spalt-like transcription factor 3

decreases expression

EXP

tributyltin results in decreased expression of SALL3 mRNA

NCBI chr18:76,680,997...76,700,905
Ensembl chr18:76,681,005...76,700,905

G

spermatogenesis associated multipass transmembrane protein 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SAMT3 mRNA

NCBI chr X:54,522,644...54,525,478
Ensembl chr X:54,522,644...54,525,478

G

SAS-6 centriolar assembly protein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SASS6 mRNA

NCBI chr 2:207,231,896...207,263,840
Ensembl chr 2:207,231,333...207,263,851

G

S-phase cyclin A-associated protein in the ER

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SCAPER mRNA

NCBI chr 8:64,828,789...65,228,240
Ensembl chr 8:64,828,789...65,228,453

G

scavenger receptor class A, member 5

decreases expression

ISO

tributyltin results in decreased expression of SCARA5 mRNA

NCBI chr15:44,055,576...44,160,593
Ensembl chr15:44,055,630...44,160,585

G

scavenger receptor class B, member 1

decreases expression

EXP

tributyltin results in decreased expression of SCARB1 mRNA; tributyltin results in decreased expression of SCARB1 protein

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

stearoyl-CoA desaturase

increases expression

ISO

tributyltin results in increased expression of SCD1 mRNA

PMID:23428407 PMID:30027469

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

stearoyl-coenzyme A desaturase 3

increases expression

ISO

tributyltin results in increased expression of SCD3 mRNA

NCBI chr 1:253,028,053...253,063,662
Ensembl chr 1:253,023,722...253,062,382

G

secretoglobin family 1D member 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SCGB1D4 mRNA

NCBI chr 1:215,755,363...215,758,238
Ensembl chr 1:215,755,363...215,758,238

G

sodium voltage-gated channel alpha subunit 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SCN5A mRNA

NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470

G

sodium voltage-gated channel alpha subunit 8

decreases expression

EXP

tributyltin results in decreased expression of SCN8A mRNA

NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:133,861,227...134,030,026

G

sodium voltage-gated channel alpha subunit 9

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SCN9A mRNA

NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:71,553,189...71,701,377

G

sterol carrier protein 2

increases expression

ISO

tributyltin results in increased expression of SCP2 mRNA

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

syndecan binding protein 2

increases expression

ISO

tributyltin results in increased expression of SDCBP2 mRNA

NCBI chr 3:160,521,309...160,558,452
Ensembl chr 3:160,530,927...160,558,446

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SDHB mRNA

NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667

G

SEC24 homolog B, COPII coat complex component

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SEC24B mRNA

NCBI chr 2:221,236,897...221,306,986
Ensembl chr 2:221,236,898...221,306,919

G

semaphorin 3B

increases expression

ISO

tributyltin results in increased expression of SEMA3B mRNA

NCBI chr 8:117,150,307...117,161,570
Ensembl chr 8:117,150,589...117,157,658

G

serpin family B member 1A

increases expression

ISO

tributyltin results in increased expression of SERPINB1A mRNA

NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166

G

SERTA domain containing 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SERTAD3 mRNA

NCBI chr 1:91,891,141...91,894,861
Ensembl chr 1:91,893,616...91,897,110

G

Set nuclear proto-oncogene

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SET protein

NCBI chr 3:33,732,319...33,743,433

G

SET like protein

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SETSIP mRNA

NCBI chr19:70,458,604...70,460,122
Ensembl chr19:70,458,522...70,461,162

G

stratifin

increases expression

ISO

tributyltin results in increased expression of SFN mRNA

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995

G

sphingosine-1-phosphate phosphatase 2

increases expression

ISO

tributyltin results in increased expression of SGPP2 mRNA

NCBI chr 9:87,211,155...87,331,787
Ensembl chr 9:87,211,717...87,333,132

G

SH2B adaptor protein 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SH2B2 mRNA

NCBI chr12:26,063,812...26,093,468
Ensembl chr12:26,064,486...26,093,467

G

SH3 and multiple ankyrin repeat domains 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SHANK2 mRNA

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736

G

sex hormone binding globulin

decreases secretion
multiple interactions

EXP

tributyltin results in decreased secretion of SHBG protein
[bisphenol A co-treated with tributyltin] results in decreased secretion of SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

shisa family member 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SHISA7 mRNA

NCBI chr 1:78,022,680...78,041,748
Ensembl chr 1:78,022,831...78,041,748

G

sialic acid binding Ig like lectin 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SIGLEC1 mRNA

NCBI chr 3:138,740,171...138,759,966
Ensembl chr 3:138,741,019...138,759,881

G

SIX homeobox 6

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SIX6 mRNA

NCBI chr 6:97,357,883...97,375,415
Ensembl chr 6:97,370,435...97,375,415

G

solute carrier family 12, member 8

increases expression

ISO

tributyltin results in increased expression of SLC12A8 mRNA

NCBI chr11:80,622,000...80,771,674
Ensembl chr11:80,622,000...80,771,659

G

solute carrier family 13 member 5

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC13A5 mRNA

NCBI chr10:57,364,806...57,389,500
Ensembl chr10:57,364,806...57,389,516

G

solute carrier family 16 member 3

increases expression

EXP

tributyltin results in increased expression of SLC16A3 mRNA; tributyltin results in increased expression of SLC16A3 protein

PMID:21683754 PMID:28993852

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 16, member 6

decreases expression

ISO

tributyltin results in decreased expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965

G

solute carrier family 18 member A2

multiple interactions

EXP

tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 5

increases expression

ISO

tributyltin results in increased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054

G

solute carrier family 1 member 6

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC1A6 mRNA

NCBI chr 7:11,492,422...11,521,007
Ensembl chr 7:11,492,422...11,553,997

G

solute carrier family 23, member 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC23A3 mRNA

NCBI chr 9:84,071,286...84,081,951
Ensembl chr 9:84,071,471...84,080,037

G

solute carrier family 25 member 20

increases expression

ISO

tributyltin results in increased expression of SLC25A20 mRNA

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027

G

solute carrier family 25 member 33

increases expression

ISO

tributyltin results in increased expression of SLC25A33 mRNA

NCBI chr 5:165,478,070...165,518,186
Ensembl chr 5:165,478,072...165,502,973

G

solute carrier family 26 member 5

increases expression

EXP

tributyltin results in increased expression of SLC26A5 mRNA

NCBI chr 4:14,102,492...14,141,520
Ensembl chr 4:14,102,492...14,141,847

G

solute carrier family 26 member 6

increases expression

ISO

tributyltin results in increased expression of SLC26A6 mRNA

NCBI chr 8:118,438,110...118,448,271
Ensembl chr 8:118,438,180...118,448,270

G

solute carrier family 27 member 1

increases expression

ISO

tributyltin results in increased expression of SLC27A1 mRNA

NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,313,015...18,330,045

G

solute carrier family 27 member 6

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SLC27A6 mRNA; [bisphenol A co-treated with tributyltin] results in increased expression of SLC27A6 protein

NCBI chr18:54,238,697...54,297,595
Ensembl chr18:54,238,729...54,312,632

G

solute carrier family 28 member 2

increases expression

ISO

tributyltin results in increased expression of SLC28A2 mRNA

NCBI chr 3:129,778,425...129,841,292
Ensembl chr 3:129,807,537...129,841,291

G

solute carrier family 2 member 2

increases expression

ISO

tributyltin results in increased expression of SLC2A2 mRNA

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 3

decreases expression

ISO

tributyltin results in decreased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 2 member 4

decreases expression

ISO

tributyltin results in decreased expression of SLC2A4 protein

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 2 member 5

increases expression

ISO

tributyltin results in increased expression of SLC2A5 mRNA

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038

G

solute carrier family 30 member 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC30A4 mRNA

NCBI chr 3:130,206,852...130,228,888
Ensembl chr 3:130,206,852...130,228,888

G

solute carrier family 30 member 9

multiple interactions
increases expression

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SLC30A9 mRNA
tributyltin results in increased expression of SLC30A9 mRNA

NCBI chr14:41,170,164...41,224,861
Ensembl chr14:41,170,166...41,224,788

G

solute carrier family 34 member 2

decreases expression

ISO

tributyltin results in decreased expression of SLC34A2 mRNA

NCBI chr14:62,123,313...62,153,020
Ensembl chr14:62,123,316...62,143,360

G

solute carrier family 37 member 1

increases expression

ISO

tributyltin results in increased expression of SLC37A1 mRNA

NCBI chr20:9,361,733...9,435,227
Ensembl chr20:9,379,664...9,435,229

G

solute carrier family 37 member 2

increases expression

ISO

tributyltin results in increased expression of SLC37A2 mRNA

NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:45,134,596...45,277,989

G

solute carrier family 39 member 5

increases expression

ISO

tributyltin results in increased expression of SLC39A5 mRNA

NCBI chr 7:1,409,360...1,415,407
Ensembl chr 7:1,409,360...1,414,784

G

solute carrier family 3 member 1

increases expression

EXP

tributyltin results in increased expression of SLC3A1 mRNA

NCBI chr 6:15,361,037...15,396,695
Ensembl chr 6:15,361,046...15,394,775

G

solute carrier family 46, member 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC46A2 mRNA

NCBI chr 5:79,594,003...79,603,074
Ensembl chr 5:79,595,150...79,603,114

G

solute carrier family 4 member 7

increases expression

ISO

tributyltin results in increased expression of SLC4A7 mRNA

NCBI chr15:13,015,854...13,095,485
Ensembl chr15:13,015,854...13,095,292

G

solute carrier family 5 member 1

increases expression

ISO

tributyltin results in increased expression of SLC5A1 mRNA

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 5 member 6

increases expression

ISO

tributyltin results in increased expression of SLC5A6 mRNA

NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:31,040,017...31,051,670

G

solute carrier family 6 member 15

decreases expression

EXP

tributyltin results in decreased expression of SLC6A15 mRNA

NCBI chr 7:40,439,607...40,493,788
Ensembl chr 7:40,439,658...40,493,786

G

solute carrier family 7 member 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SLC7A3 mRNA

NCBI chr X:70,250,089...70,256,610
Ensembl chr X:70,250,099...70,256,059

G

small integral membrane protein 13

decreases expression

EXP

tributyltin results in decreased expression of SMIM13 mRNA

NCBI chr17:23,703,414...23,721,457
Ensembl chr17:23,703,414...23,721,457

G

small integral membrane protein 24

increases expression

ISO

tributyltin results in increased expression of SMIM24 mRNA

NCBI chr 7:8,964,107...8,967,234
Ensembl chr 7:8,964,107...8,967,234

G

sphingomyelin phosphodiesterase, acid-like 3B

increases expression

ISO

tributyltin results in increased expression of SMPDL3B mRNA

NCBI chr 5:150,228,607...150,250,688
Ensembl chr 5:150,228,611...150,250,688

G

suppressor of cytokine signaling 3

decreases expression

ISO

tributyltin results in decreased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

sorbin and SH3 domain containing 1

increases expression

ISO

tributyltin results in increased expression of SORBS1 mRNA

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:249,057,324...249,279,608

G

SRY-box transcription factor 5

decreases expression

ISO

tributyltin results in decreased expression of SOX5 mRNA

NCBI chr 4:178,512,272...179,467,686
Ensembl chr 4:178,512,272...178,938,495

G

SRY-box transcription factor 6

decreases expression

ISO

tributyltin results in decreased expression of SOX6 mRNA

NCBI chr 1:179,157,678...179,769,243
Ensembl chr 1:179,163,566...179,711,727

G

SRY-box transcription factor 9

multiple interactions
decreases expression

ISO

[tributyltin co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX9 mRNA
tributyltin results in decreased expression of SOX9 mRNA

PMID:22749964 PMID:24513447

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

Sp7 transcription factor

multiple interactions
decreases expression

ISO

tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]
tributyltin results in decreased expression of SP7 mRNA

PMID:25777084 PMID:25932594

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

spastin

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SPAST mRNA

NCBI chr 6:26,807,220...26,858,456
Ensembl chr 6:26,807,220...26,858,446

G

spermatogenesis associated 22

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SPATA22 mRNA

NCBI chr10:58,443,736...58,461,578
Ensembl chr10:58,417,415...58,461,908

G

sphingosine kinase 1

decreases expression

ISO

tributyltin results in decreased expression of SPHK1 mRNA

NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082

G

serine peptidase inhibitor, Kazal type 1

increases expression

ISO

tributyltin results in increased expression of SPINK1 mRNA

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

serine peptidase inhibitor, Kunitz type 1

increases expression

ISO

tributyltin results in increased expression of SPINT1 mRNA

NCBI chr 3:126,685,017...126,697,957
Ensembl chr 3:126,685,422...126,697,956

G

sperm microtubule inner protein 9

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of SPMIP9 mRNA

NCBI chr 4:104,444,049...104,451,286
Ensembl chr 4:104,444,045...104,451,286

G

spondin 2

increases expression

EXP

tributyltin results in increased expression of SPON2 mRNA

NCBI chr14:81,713,070...81,742,510
Ensembl chr14:81,731,188...81,742,609

G

spectrin, alpha, non-erythrocytic 1

increases cleavage

EXP

tributyltin results in increased cleavage of SPTAN1 protein

NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:33,607,210...33,703,889

G

serine palmitoyltransferase, small subunit A

increases expression

EXP

tributyltin results in increased expression of SPTSSA mRNA

NCBI chr 6:77,879,931...77,891,344
Ensembl chr 6:77,879,941...77,891,403

G

sequestosome 1

increases expression

ISO

tributyltin results in increased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

SRC proto-oncogene, non-receptor tyrosine kinase

affects methylation

ISO

tributyltin affects the methylation of SRC 5' UTR; tributyltin affects the methylation of SRC exon; tributyltin affects the methylation of SRC promoter

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

steroid 5 alpha-reductase 1

decreases activity
multiple interactions

ISO

tributyltin results in decreased activity of SRD5A1 protein
[Finasteride co-treated with tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA; [tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA

PMID:12231121 PMID:23523586

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903

G

steroid 5 alpha-reductase 2

decreases activity
multiple interactions
increases expression

ISO
EXP

tributyltin results in decreased activity of SRD5A2 protein
Finasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]; tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]; tributyltin promotes the reaction [Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]
tributyltin results in increased expression of SRD5A2 mRNA

PMID:12231121 PMID:21683754 PMID:23523586

NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

ISO

[tributyltin co-treated with LHB protein] results in increased expression of SREBF1 mRNA; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]
tributyltin results in increased expression of SREBF1 mRNA

PMID:23322813 PMID:25932594 PMID:28011154 PMID:38630605

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sushi-repeat-containing protein, X-linked 2

increases expression

EXP

tributyltin results in increased expression of SRPX2 mRNA

NCBI chr X:101,399,748...101,425,486
Ensembl chr X:101,399,853...101,425,484

G

SS nuclear autoantigen 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SSNA1 mRNA

NCBI chr 3:28,483,107...28,484,571
Ensembl chr 3:28,483,107...28,484,608

G

ST14 transmembrane serine protease matriptase

increases expression

ISO

tributyltin results in increased expression of ST14 mRNA

NCBI chr 8:37,798,994...37,839,881
Ensembl chr 8:37,798,995...37,855,652

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ST3GAL3 mRNA

NCBI chr 5:136,755,780...136,958,081
Ensembl chr 5:136,755,678...136,955,987

G

suppression of tumorigenicity 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ST7 mRNA

NCBI chr 4:47,007,568...47,255,639
Ensembl chr 4:47,008,095...47,255,637

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

decreases expression

EXP

tributyltin results in decreased expression of ST8SIA6 mRNA

NCBI chr17:81,649,866...81,847,970
Ensembl chr17:81,653,687...81,792,732

G

steroidogenic acute regulatory protein

decreases expression
increases expression

EXP
ISO

tributyltin results in decreased expression of STAR mRNA; tributyltin results in decreased expression of STAR protein
tributyltin results in increased expression of STAR mRNA

PMID:28707438 PMID:29549738 PMID:31006824 PMID:35430282

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

STEAP4 metalloreductase

decreases expression

ISO

tributyltin results in decreased expression of STEAP4 mRNA

NCBI chr 4:27,032,096...27,054,769
Ensembl chr 4:27,009,584...27,067,105

G

serine threonine kinase 31

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of STK31 mRNA

NCBI chr 4:79,701,470...79,797,085
Ensembl chr 4:79,694,606...79,797,354

G

storkhead box 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of STOX1 mRNA

NCBI chr20:31,140,993...31,209,126
Ensembl chr20:31,140,993...31,208,877

G

stereocilin

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of STRC mRNA

NCBI chr 3:128,785,817...128,811,773
Ensembl chr 3:128,789,290...128,808,023

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

increases expression

ISO

tributyltin results in increased expression of SUCLG1 mRNA

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

sulfotransferase family 1C member 2A

increases expression

ISO

tributyltin results in increased expression of SULT1C2 mRNA

NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132

G

sulfotransferase family 2B member 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of SULT2B1 mRNA

NCBI chr 1:105,336,614...105,397,744
Ensembl chr 1:105,336,614...105,397,744

G

synaptic vesicle glycoprotein 2b

increases expression

EXP

tributyltin results in increased expression of SV2B mRNA

NCBI chr 1:138,388,268...138,562,635
Ensembl chr 1:138,388,266...138,562,258

G

syntabulin

decreases expression

ISO

tributyltin results in decreased expression of SYBU mRNA

NCBI chr 7:77,731,662...77,833,413
Ensembl chr 7:77,731,605...77,833,686

G

spleen associated tyrosine kinase

increases expression

ISO

tributyltin results in increased expression of SYK mRNA

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278

G

synaptopodin 2

increases expression

ISO

tributyltin results in increased expression of SYNPO2 mRNA

NCBI chr 2:213,901,685...214,055,844
Ensembl chr 2:213,900,868...214,055,844

G

synaptotagmin 12

decreases expression

ISO

tributyltin results in decreased expression of SYT12 mRNA

NCBI chr 1:211,158,745...211,189,780
Ensembl chr 1:211,159,800...211,189,037

G

synaptotagmin 4

increases expression

EXP

tributyltin results in increased expression of SYT4 mRNA

NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815

G

synaptotagmin-like 4

decreases expression
multiple interactions

EXP

tributyltin results in decreased expression of SYTL4 mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of SYTL4 mRNA

NCBI chr X:101,428,785...101,479,207
Ensembl chr X:101,428,785...101,479,151

G

transforming, acidic coiled-coil containing protein 2

decreases expression

ISO

tributyltin results in decreased expression of TACC2 mRNA

NCBI chr 1:194,546,428...194,758,152
Ensembl chr 1:194,569,650...194,758,152

G

TATA-box binding protein associated factor, RNA polymerase I subunit A

increases expression
multiple interactions

EXP

tributyltin results in increased expression of TAF1A mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of TAF1A mRNA

NCBI chr13:97,543,772...97,579,742
Ensembl chr13:97,560,820...97,579,737

G

transport and golgi organization 6 homolog

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TANGO6 mRNA

NCBI chr19:51,479,384...51,667,142
Ensembl chr19:51,479,391...51,687,621

G

taste receptor, type 2, member 135

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TAS2R135 mRNA

NCBI chr 4:72,259,539...72,260,504
Ensembl chr 4:72,259,539...72,260,504

G

transcription activation suppressor family member 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TASOR2 mRNA

NCBI chr17:71,504,656...71,559,878
Ensembl chr17:71,504,822...71,559,035

G

T-box transcription factor 20

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TBX20 mRNA

NCBI chr 8:31,475,963...31,534,051
Ensembl chr 8:31,475,963...31,534,009

G

transcription factor 23

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TCF23 mRNA

NCBI chr 6:31,117,839...31,126,575
Ensembl chr 6:31,120,127...31,125,878

G

tectonin beta-propeller repeat containing 1

increases expression

EXP

tributyltin results in increased expression of TECPR1 mRNA

NCBI chr12:15,504,456...15,534,541
Ensembl chr12:15,505,343...15,534,116

G

TEF transcription factor, PAR bZIP family member

increases expression

ISO

tributyltin results in increased expression of TEF mRNA

NCBI chr 7:115,197,180...115,221,930
Ensembl chr 7:115,193,282...115,221,928

G

telomerase reverse transcriptase

increases expression

ISO

tributyltin results in increased expression of TERT mRNA

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

testis expressed metallothionein like protein

decreases expression

EXP

tributyltin results in decreased expression of TESMIN protein

PMID:24055800 PMID:28707438

NCBI chr 1:210,059,414...210,077,704
Ensembl chr 1:210,059,393...210,077,703

G

testis expressed 38

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TEX38 mRNA

NCBI chr 5:134,498,309...134,502,352
Ensembl chr 5:134,497,501...134,503,041

G

transferrin

increases expression

EXP

tributyltin results in increased expression of TF mRNA

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

transferrin receptor

increases expression

ISO

tributyltin results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transforming growth factor alpha

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TGFA mRNA

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

transforming growth factor, beta 1

increases expression

ISO

tributyltin results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transglutaminase 2

multiple interactions
increases expression

ISO

diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of TGM2 mRNA]

PMID:21622945 PMID:25932594

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

thyroid hormone receptor alpha

multiple interactions

ISO

tributyltin binds to and results in increased activity of THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor beta

increases expression
multiple interactions

ISO

tributyltin results in increased expression of THRB mRNA
tributyltin binds to and results in increased activity of THRB protein

PMID:30027469 PMID:33049310

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

thyroid hormone responsive

increases expression

EXP

tributyltin results in increased expression of THRSP mRNA

NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827

G

Thy-1 cell surface antigen

decreases expression

ISO

tributyltin results in decreased expression of THY1 mRNA

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

TIMELESS interacting protein like 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TIPINL1 mRNA

NCBI chr 9:120,989,415...120,994,276

G

tight junction protein 1

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

TLC domain containing 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TLCD4 mRNA

NCBI chr 2:211,969,612...212,044,883
Ensembl chr 2:211,974,471...212,026,081

G

TLE family member 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TLE7 mRNA

NCBI chr19:54,982,299...54,994,086
Ensembl chr19:54,982,049...54,994,085

G

transmembrane 4 L six family member 20

increases expression

ISO

tributyltin results in increased expression of TM4SF20 mRNA

NCBI chr 9:91,486,847...91,500,745
Ensembl chr 9:91,486,847...91,500,745

G

transmembrane channel-like 4

increases expression

ISO

tributyltin results in increased expression of TMC4 mRNA

NCBI chr 1:74,455,135...74,467,043
Ensembl chr 1:74,454,909...74,467,043

G

transmembrane protein 106A

increases expression

EXP

tributyltin results in increased expression of TMEM106A mRNA

NCBI chr10:87,007,144...87,016,161
Ensembl chr10:87,007,165...87,016,157

G

transmembrane protein 128

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TMEM128 mRNA

NCBI chr14:76,751,848...76,761,576
Ensembl chr14:76,752,603...76,772,217

G

transmembrane protein 171

decreases expression

EXP

tributyltin results in decreased expression of TMEM171 mRNA

NCBI chr 2:31,769,486...31,779,358
Ensembl chr 2:31,769,486...31,780,134

G

transmembrane protein 213

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TMEM213 mRNA

NCBI chr 4:67,792,010...67,798,039
Ensembl chr 4:67,779,801...67,798,039

G

transmembrane protein 45b

increases expression

ISO

tributyltin results in increased expression of TMEM45B mRNA

NCBI chr 8:38,123,423...38,168,599
Ensembl chr 8:38,123,423...38,168,599

G

transmembrane protein 71

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TMEM71 mRNA

NCBI chr 7:100,166,038...100,212,234
Ensembl chr 7:100,166,516...100,204,969

G

transmembrane protein 91

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TMEM91 mRNA

NCBI chr 1:90,307,264...90,314,796
Ensembl chr 1:90,306,289...90,313,320

G

tropomodulin 1

increases expression

EXP

tributyltin results in increased expression of TMOD1 mRNA

NCBI chr 5:65,112,062...65,189,563
Ensembl chr 5:65,134,132...65,189,561

G

transmembrane serine protease 4

increases expression

ISO

tributyltin results in increased expression of TMPRSS4 mRNA

NCBI chr 8:54,372,805...54,405,157
Ensembl chr 8:54,372,805...54,405,157

G

thioredoxin-related transmembrane protein 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TMX3 mRNA

NCBI chr18:86,021,137...86,054,025
Ensembl chr18:86,021,084...86,054,198

G

tumor necrosis factor

multiple interactions
affects expression
increases expression

ISO
EXP

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of TNF protein]; batimastat inhibits the reaction [tributyltin results in increased secretion of TNF protein]; tributyltin affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; tributyltin results in increased expression of and results in increased secretion of TNF protein
tributyltin affects the expression of TNF mRNA
tributyltin results in increased expression of TNF mRNA
tributyltin results in increased expression of TNF protein

PMID:17092623 PMID:29532501 PMID:30172001 PMID:36319700

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

multiple interactions

ISO
EXP

tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased secretion of TNFRSF11B protein]
[bisphenol A co-treated with tributyltin] results in increased expression of TNFRSF11B mRNA

PMID:31016361 PMID:31129395

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 19

increases expression

ISO

tributyltin results in increased expression of TNFRSF19 mRNA

NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438

G

TNF receptor superfamily member 9

decreases expression

EXP

tributyltin results in decreased expression of TNFRSF9 mRNA

NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831

G

TNF superfamily member 11

multiple interactions

ISO

Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TOG array regulator of axonemal microtubules 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TOGARAM1 mRNA

NCBI chr 6:88,755,264...88,819,599
Ensembl chr 6:88,755,264...88,819,598

G

torsin family 3, member A

decreases expression

ISO

tributyltin results in decreased expression of TOR3A mRNA

NCBI chr13:71,324,073...71,348,625
Ensembl chr13:71,324,076...71,348,624

G

TOX high mobility group box family member 4

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TOX4 mRNA

NCBI chr15:27,462,735...27,476,320
Ensembl chr15:27,462,727...27,477,617

G

tumor protein p53

increases expression
multiple interactions
decreases expression

ISO

tributyltin results in increased expression of TP53 protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of TP53 protein]
tributyltin results in increased expression of TRP53 protein
tributyltin results in decreased expression of TP53 protein

PMID:25743928 PMID:26961604 PMID:33720505 PMID:36319700

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible nuclear protein 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TP53INP2 mRNA

NCBI chr 3:164,341,618...164,350,270
Ensembl chr 3:164,343,205...164,350,225

G

tyrosylprotein sulfotransferase 1

increases expression
multiple interactions

EXP

tributyltin results in increased expression of TPST1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of TPST1 mRNA

NCBI chr12:32,180,688...32,247,478
Ensembl chr12:32,180,936...32,241,821

G

tetratricopeptide repeat and ankyrin repeat containing 1

decreases expression

EXP

tributyltin results in decreased expression of TRANK1 mRNA

NCBI chr 8:120,153,381...120,233,879
Ensembl chr 8:120,154,362...120,234,087

G

trehalase

increases expression

ISO

tributyltin results in increased expression of TREH mRNA

NCBI chr 8:53,886,946...53,901,113
Ensembl chr 8:53,886,946...53,900,335

G

tribbles pseudokinase 3

increases expression

EXP

tributyltin results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 47

increases expression

EXP

tributyltin results in increased expression of TRIM47 mRNA

NCBI chr10:101,836,465...101,840,936
Ensembl chr10:101,836,465...101,840,936

G

tripartite motif containing 71

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TRIM71 mRNA

NCBI chr 8:123,076,499...123,129,016

G

transient receptor potential cation channel, subfamily M, member 4

increases expression

ISO

tributyltin results in increased expression of TRPM4 mRNA

NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:104,918,462...104,948,653

G

transient receptor potential cation channel, subfamily V, member 1

decreases expression

EXP

tributyltin results in decreased expression of TRPV1 mRNA

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

TSC22 domain family, member 3

decreases expression

ISO

tributyltin results in decreased expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

tetraspanin 15

increases expression

ISO

tributyltin results in increased expression of TSPAN15 mRNA

NCBI chr20:30,673,271...30,717,651
Ensembl chr20:30,673,272...30,717,651

G

tetraspanin 3

increases expression

ISO

tributyltin results in increased expression of TSPAN3 mRNA

NCBI chr 8:65,442,100...65,465,961
Ensembl chr 8:65,442,101...65,465,844

G

tetraspanin 8

increases expression

ISO

tributyltin results in increased expression of TSPAN8 mRNA

NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:53,330,963...53,365,401

G

translocator protein

increases expression
affects expression

EXP

tributyltin results in increased expression of TSPO mRNA
tributyltin affects the expression of TSPO protein

PMID:21683754 PMID:28707438

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460

G

testis specific X-linked gene

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TSX mRNA

NCBI chr X:72,493,147...72,503,653
Ensembl chr X:72,489,226...72,503,653

G

tetratricopeptide repeat domain 21A

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TTC21A mRNA

NCBI chr 8:128,544,684...128,580,464
Ensembl chr 8:128,544,734...128,580,086

G

tubulin tyrosine ligase

multiple interactions
decreases expression

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of TTL mRNA
tributyltin results in decreased expression of TTL mRNA

NCBI chr 3:136,752,025...136,781,758
Ensembl chr 3:136,752,000...136,781,758

G

tubulin, beta 1 class VI

decreases expression

ISO

tributyltin results in decreased expression of TUBB1 mRNA

NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:183,666,242...183,674,795

G

tubulin, beta 2A class IIa

decreases expression

ISO

tributyltin results in decreased expression of TUBB2A mRNA

NCBI chr17:31,002,186...31,006,057
Ensembl chr17:30,983,387...31,006,838

G

tubulin, beta 3 class III

increases degradation
multiple interactions

ISO

tributyltin results in increased degradation of TUBB3 protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of TUBB3 protein]

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

tubulin, beta 6 class V

decreases expression

ISO

tributyltin results in decreased expression of TUBB6 mRNA

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

tubulin, gamma 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TUBG1 mRNA

NCBI chr10:86,553,143...86,559,733
Ensembl chr10:86,552,499...86,559,730

G

tubulin gamma complex component 3

decreases expression

EXP

tributyltin results in decreased expression of TUBGCP3 mRNA

NCBI chr16:83,553,950...83,614,626
Ensembl chr16:83,553,959...83,614,623

G

twist family bHLH transcription factor 1

multiple interactions
decreases expression

ISO

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of TWIST1 mRNA]

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965

G

thioredoxin interacting protein

increases expression

EXP

tributyltin results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

tRNA-yW synthesizing protein 3 homolog

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of TYW3 mRNA

NCBI chr 2:246,189,627...246,211,737
Ensembl chr 2:246,189,632...246,220,025

G

uveal autoantigen with coiled-coil domains and ankyrin repeats

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of UACA mRNA

NCBI chr 8:70,155,059...70,243,416
Ensembl chr 8:70,155,047...70,243,415

G

ubiquitin-conjugating enzyme E2Q family member 2-like

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of UBE2Q2L mRNA

NCBI chr X:12,511,958...12,513,479
Ensembl chr X:12,511,895...12,513,952

G

ubiquitin protein ligase E3 component n-recognin 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of UBR1 mRNA

NCBI chr 3:128,265,160...128,377,830
Ensembl chr 3:128,265,115...128,375,671

G

uncoupling protein 1

increases expression

ISO

tributyltin results in increased expression of UCP1 mRNA

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

uncoupling protein 2

increases expression

ISO

tributyltin results in increased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

EXP

tributyltin results in increased expression of UGT1A5 mRNA

NCBI chr 9:96,228,134...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

unc-119 lipid binding chaperone B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of UNC119B mRNA

NCBI chr12:47,139,492...47,152,115
Ensembl chr12:47,139,545...47,152,112

G

unc-5 netrin receptor D

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of UNC5D mRNA

NCBI chr16:69,563,099...70,109,862
Ensembl chr16:69,563,212...70,104,078

G

uroplakin 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of UPK2 mRNA

NCBI chr 8:53,675,994...53,677,986
Ensembl chr 8:53,675,994...53,677,986

G

uridine phosphorylase 1

increases expression

ISO

tributyltin results in increased expression of UPP1 mRNA

NCBI chr14:88,023,155...88,043,036
Ensembl chr14:88,023,351...88,043,034

G

uridine phosphorylase 2

increases expression

ISO

tributyltin results in increased expression of UPP2 mRNA

NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:63,681,826...63,726,191

G

ubiquitin specific peptidase 2

increases expression

ISO

tributyltin results in increased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794

G

ubiquitin specific peptidase 43

increases expression

ISO

tributyltin results in increased expression of USP43 mRNA

NCBI chr10:53,047,368...53,110,099
Ensembl chr10:53,048,158...53,110,180

G

vav guanine nucleotide exchange factor 3

increases expression

ISO

tributyltin results in increased expression of VAV3 mRNA

NCBI chr 2:199,699,861...200,042,344
Ensembl chr 2:199,700,445...200,042,343

G

vitamin D receptor

decreases expression

ISO

tributyltin results in decreased expression of VDR mRNA

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

villin 1

increases expression

ISO

tributyltin results in increased expression of VIL1 mRNA

NCBI chr 9:83,440,248...83,467,963
Ensembl chr 9:83,440,248...83,467,961

G

vimentin

decreases expression
multiple interactions

ISO

tributyltin results in decreased expression of VIM mRNA; tributyltin results in decreased expression of VIM protein
Tretinoin promotes the reaction [tributyltin results in decreased expression of VIM mRNA]; Tretinoin promotes the reaction [tributyltin results in decreased expression of VIM protein]

PMID:30806631 PMID:31634547

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vomeronasal 1 receptor 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of VOM1R2 mRNA

NCBI chr 1:67,948,868...67,949,776

G

vomeronasal 1 receptor 85

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of VOM1R85 mRNA

NCBI chr 4:88,491,121...88,492,029
Ensembl chr 4:88,491,121...88,492,029

G

vomeronasal 2 receptor, 22

increases expression

EXP

tributyltin results in increased expression of VOM2R22 mRNA

NCBI chr 1:72,340,820...72,374,030

G

vomeronasal 2 receptor, 61

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of VOM2R61 mRNA

NCBI chr12:22,551,416...22,579,304

G

vomeronasal 2 receptor, 64

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of VOM2R64 mRNA

NCBI chr12:24,123,536...24,153,307
Ensembl chr12:24,123,536...24,153,307

G

vomeronasal 2 receptor, 79

decreases expression

EXP

tributyltin results in decreased expression of VOM2R79 mRNA

NCBI chr 9:2,592,854...2,640,375
Ensembl chr 9:2,592,854...2,640,375

G

V-set pre-B cell surrogate light chain 1A

increases expression

ISO

tributyltin results in increased expression of VPREB1 mRNA

NCBI chr11:97,631,174...97,632,051
Ensembl chr11:97,629,102...97,632,051

G

visual system homeobox 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of VSX1 mRNA

NCBI chr 3:159,974,693...159,982,292
Ensembl chr 3:159,974,693...159,982,292

G

WD repeat domain 3

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of WDR3 mRNA

NCBI chr 2:190,194,474...190,217,087
Ensembl chr 2:190,194,474...190,217,087

G

WD repeat domain 91

increases expression

EXP

tributyltin results in increased expression of WDR91 mRNA

NCBI chr 4:64,521,504...64,558,873
Ensembl chr 4:64,521,504...64,558,873

G

WEE1 G2 checkpoint kinase

increases expression

ISO

tributyltin results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

Wnt family member 5A

decreases expression

ISO

tributyltin results in decreased expression of WNT5A mRNA

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860

G

WRN helicase interacting protein 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of WRNIP1 mRNA

NCBI chr17:31,830,159...31,850,408
Ensembl chr17:31,830,160...31,850,408

G

X-box binding protein 1

increases splicing

ISO

tributyltin results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

XPA, DNA damage recognition and repair factor

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of XPA mRNA

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425

G

yippee-like 2

decreases expression

ISO

tributyltin results in decreased expression of YPEL2 mRNA

NCBI chr10:72,243,591...72,301,124
Ensembl chr10:72,243,591...72,301,124

G

zinc finger and BTB domain containing 16

decreases expression

ISO

tributyltin results in decreased expression of ZBTB16 mRNA

NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507

G

zinc finger and BTB domain containing 39

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ZBTB39 mRNA

NCBI chr 7:65,462,255...65,469,806
Ensembl chr 7:65,462,018...65,485,601

G

zinc finger and BTB domain containing 7B

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ZBTB7B mRNA

NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:177,095,185...177,109,031

G

zinc finger and BTB domain containing 7C

decreases expression

ISO

tributyltin results in decreased expression of ZBTB7C mRNA

NCBI chr18:71,716,586...72,045,831
Ensembl chr18:71,716,623...72,040,339

G

zinc finger DHHC-type palmitoyltransferase 2

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ZDHHC2 mRNA

NCBI chr16:58,511,931...58,581,530
Ensembl chr16:58,511,934...58,581,516

G

zinc finger protein 24

decreases expression

EXP

tributyltin results in decreased expression of ZFP24 mRNA

NCBI chr18:15,573,031...15,583,432
Ensembl chr18:15,574,762...15,582,290

G

zinc finger protein 281

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ZFP281 mRNA

NCBI chr13:50,647,750...50,655,912
Ensembl chr13:50,588,874...50,675,781

G

zinc finger protein 36

increases expression

EXP

tributyltin results in increased expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 423

increases expression

ISO

tributyltin results in increased expression of ZFP423 mRNA

NCBI chr19:35,282,149...35,580,775
Ensembl chr19:35,282,110...35,580,773

G

zinc finger protein 68

increases expression
multiple interactions

EXP

tributyltin results in increased expression of ZFP300 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of ZFP300 mRNA

NCBI chr12:21,139,838...21,154,775
Ensembl chr12:21,139,868...21,154,769

G

zinc finger protein 74

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ZFP74 mRNA

NCBI chr 1:94,285,571...94,310,896
Ensembl chr 1:94,286,403...94,296,347

G

zinc finger protein 800

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ZFP800 mRNA

NCBI chr 4:57,763,789...57,977,318
Ensembl chr 4:57,767,506...57,814,209

G

zinc finger with KRAB and SCAN domains 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in increased expression of ZKSCAN1 mRNA

NCBI chr12:22,080,319...22,101,389
Ensembl chr12:22,080,324...22,101,387

G

zinc finger with KRAB and SCAN domains 7

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ZKSCAN7 mRNA

NCBI chr 8:131,379,514...131,397,065
Ensembl chr 8:131,378,013...131,397,065

G

zinc finger, matrin-type 1

multiple interactions

EXP

[bisphenol A co-treated with tributyltin] results in decreased expression of ZMAT1 mRNA

NCBI chr X:102,461,621...102,520,818
Ensembl chr X:102,461,919...102,520,758

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

allograft inflammatory factor 1

increases expression
multiple interactions

ISO

trimethyltin results in increased expression of AIF1 mRNA; trimethyltin results in increased expression of AIF1 protein
magnolol inhibits the reaction [trimethyltin results in increased expression of AIF1 protein]

PMID:24002884 PMID:26756313

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

arginase 1

multiple interactions

EXP

[trimethyltin chloride results in increased abundance of trimethyltin] which results in decreased expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

activating transcription factor 3

increases expression

ISO

trimethyltin results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

BCL2-associated agonist of cell death

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]

PMID:25895139 PMID:26756313

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; magnolol inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]

PMID:25895139 PMID:26756313

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

complement C1q A chain

increases expression

ISO

trimethyltin results in increased expression of C1QA mRNA

NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732

G

complement C1q B chain

increases expression

ISO

trimethyltin results in increased expression of C1QB mRNA

PMID:21435392 PMID:24002884

NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840

G

caspase 3

multiple interactions
increases activity
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]; magnolol inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
trimethyltin results in increased expression of CASP3 mRNA; trimethyltin results in increased expression of CASP3 protein modified form

PMID:20886113 PMID:21435392 PMID:22634143 PMID:24002884 PMID:25895139 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 2

increases expression

ISO

trimethyltin results in increased expression of CCL2 mRNA

PMID:21435392 PMID:24002884

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases expression

ISO

trimethyltin results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

increases expression

ISO

trimethyltin results in increased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

CD44 molecule

increases expression

ISO

trimethyltin results in increased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

CD86 molecule

multiple interactions

EXP

[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

CASP8 and FADD-like apoptosis regulator

increases expression

ISO

trimethyltin results in increased expression of CFLAR mRNA

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

ISO

trimethyltin results in increased expression of CHUK mRNA

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

C-X-C motif chemokine ligand 1

multiple interactions

EXP

[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

cytochrome c, somatic

decreases expression

ISO

trimethyltin results in decreased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

EXP

trimethyltin results in decreased expression of CYP11A1 mRNA
trimethyltin results in decreased expression of and results in decreased activity of CYP11A1 protein

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

Fas cell surface death receptor

increases expression

ISO

trimethyltin results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

trimethyltin results in increased expression of FASL mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fibroblast growth factor 21

increases expression

ISO

trimethyltin results in increased expression of FGF21 mRNA

NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO

trimethyltin results in increased expression of GCLC mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glial fibrillary acidic protein

increases expression
multiple interactions

ISO

trimethyltin results in increased expression of GFAP mRNA; trimethyltin results in increased expression of GFAP protein
magnolol inhibits the reaction [trimethyltin results in increased expression of GFAP protein]

PMID:24002884 PMID:26756313 PMID:27729293

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

growth factor receptor bound protein 2

increases expression

ISO

trimethyltin results in increased expression of GRB2 mRNA

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

ISO

trimethyltin results in decreased expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate metabotropic receptor 3

decreases expression

ISO

trimethyltin results in decreased expression of GRM3 mRNA

NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:25,319,942...25,564,764

G

hypoxia inducible factor 1 subunit alpha

increases expression

ISO

trimethyltin results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

increases expression
multiple interactions

ISO

trimethyltin results in increased expression of HMOX1 protein
trimethyltin results in increased expression of HMOX1 mRNA
magnolol inhibits the reaction [trimethyltin results in increased expression of HMOX1 protein]

PMID:26756313 PMID:27729293

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

HR, lysine demethylase and nuclear receptor corepressor

affects response to substance
multiple interactions

ISO

HR protein affects the susceptibility to trimethyltin
HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]

NCBI chr15:52,036,540...52,056,019
Ensembl chr15:52,036,540...52,056,015

G

HRas proto-oncogene, GTPase

increases expression

ISO

trimethyltin results in increased expression of HRAS mRNA

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

ISO
EXP

1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; [[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased activity of HSD11B1 protein; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

EXP

trimethyltin results in decreased expression of and results in decreased activity of HSD17B3 protein
trimethyltin results in decreased expression of HSD17B3 mRNA

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

interferon gamma

increases expression

ISO

trimethyltin results in increased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1

increases expression

ISO

trimethyltin results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

interleukin 10

increases expression

ISO

trimethyltin results in increased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 alpha

increases expression

ISO

trimethyltin results in increased expression of IL1A mRNA

PMID:20833246 PMID:21435392 PMID:24002884

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 receptor type 1

increases expression

ISO

trimethyltin results in increased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 1 receptor antagonist

increases expression

ISO

trimethyltin results in increased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 6

increases expression
multiple interactions
decreases expression
decreases response to substance

ISO
EXP

trimethyltin results in increased expression of IL6 mRNA; trimethyltin results in increased expression of IL6 protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased secretion of IL6 protein; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Dexamethasone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; INS1 protein inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
trimethyltin results in decreased expression of IL6 mRNA
IL6 results in decreased susceptibility to trimethyltin

PMID:20833246 PMID:21435392 PMID:24002884 PMID:30993381

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

increases expression

ISO

trimethyltin results in increased expression of IL6RA protein

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interleukin 6 cytokine family signal transducer

increases expression

ISO

trimethyltin results in increased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

insulin 1

multiple interactions

ISO

INS1 protein inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions

EXP

[trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

integrin subunit alpha M

increases expression
multiple interactions

ISO
EXP

trimethyltin results in increased expression of ITGAM mRNA
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of ITGAM mRNA

PMID:24002884 PMID:30993381

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

Janus kinase 1

increases expression

ISO

trimethyltin results in increased expression of JAK1 mRNA

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

trimethyltin results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lipocalin 2

increases expression

ISO

trimethyltin results in increased expression of LCN2 mRNA

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

Ly6/neurotoxin 1

decreases expression

ISO

trimethyltin results in decreased expression of LYNX1 mRNA

NCBI chr 7:108,521,783...108,527,012
Ensembl chr 7:108,521,780...108,527,130

G

microtubule-associated protein 1 light chain 3 beta

decreases degradation

EXP

trimethyltin results in decreased degradation of MAP1LC3B protein modified form

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase kinase 1

increases expression

ISO

trimethyltin results in increased expression of MAP2K1 mRNA

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen-activated protein kinase kinase 6

decreases expression

ISO

trimethyltin results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen activated protein kinase 1

increases expression

ISO

trimethyltin results in increased expression of MAPK1 mRNA

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases expression

ISO

trimethyltin results in increased expression of MAPK3 mRNA

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

ISO

trimethyltin results in increased phosphorylation of MAPK8 protein
magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

ISO

magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

marker of proliferation Ki-67

increases expression

ISO

trimethyltin results in increased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

mannose receptor, C type 1

multiple interactions

EXP

[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of MRC1 mRNA

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

MYD88, innate immune signal transduction adaptor

increases expression

ISO

trimethyltin results in increased expression of MYD88 mRNA

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

neurofilament heavy chain

multiple interactions

EXP

[trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA]

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

neurofilament light chain

increases secretion

EXP

trimethyltin results in increased secretion of NEFL protein

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]; trimethyltin affects the localization of and results in increased activity of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions
increases phosphorylation

ISO

magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA; magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]

PMID:26756313 PMID:30993381

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

EXP

trimethyltin results in decreased expression of NR5A1 mRNA; trimethyltin results in decreased expression of NR5A1 protein

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

neurotrophin 3

decreases expression

ISO

trimethyltin results in decreased expression of NTF3 mRNA

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

neurotrophic receptor tyrosine kinase 3

decreases expression

ISO

trimethyltin results in decreased expression of NTRK3 mRNA

NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004

G

protein kinase C, delta

multiple interactions

ISO

rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]; trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein tyrosine phosphatase, non-receptor type 11

increases expression

ISO

trimethyltin results in increased expression of PTPN11 mRNA

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

ISO

trimethyltin results in increased expression of PTPN6 mRNA

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

Rac family small GTPase 1

increases expression

ISO

trimethyltin results in increased expression of RAC1 mRNA

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression

ISO

trimethyltin results in increased expression of RAF1 mRNA

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RAS related 2

increases expression

ISO

trimethyltin results in increased expression of RRAS2 mRNA

NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:177,668,144...177,737,551

G

SHC adaptor protein 1

increases expression

ISO

trimethyltin results in increased expression of SHC1 mRNA

NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914

G

SOS Ras/Rac guanine nucleotide exchange factor 1

increases expression

ISO

trimethyltin results in increased expression of SOS1 mRNA

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

secreted phosphoprotein 1

increases expression

ISO

trimethyltin results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sequestosome 1

decreases degradation

EXP

trimethyltin results in decreased degradation of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

serum response factor

decreases expression

ISO

trimethyltin results in decreased expression of SRF mRNA

NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:21,924,076...21,933,337

G

steroidogenic acute regulatory protein

decreases expression

EXP

trimethyltin results in decreased expression of STAR mRNA; trimethyltin results in decreased expression of STAR protein

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

increases expression

ISO

trimethyltin results in increased expression of STAT3 mRNA; trimethyltin results in increased expression of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

increases expression

ISO

trimethyltin results in increased expression of TGFB1 mRNA

PMID:21435392 PMID:24002884

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

increases expression
multiple interactions
increases secretion

ISO
EXP

trimethyltin results in increased expression of TNF mRNA
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of TNF mRNA
magnolol inhibits the reaction [trimethyltin results in increased secretion of TNF protein]

PMID:21435392 PMID:24002884 PMID:26756313 PMID:30993381

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

increases expression

ISO

trimethyltin results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 1A

increases expression

ISO

trimethyltin results in increased expression of TNFRSF1A mRNA

PMID:21435392 PMID:24002884

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 25

increases expression

ISO

trimethyltin results in increased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:167,904,786...167,909,052

G

toll interacting protein

increases expression

ISO

trimethyltin results in increased expression of TOLLIP mRNA

NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988

G

tumor protein p53

increases activity

ISO

trimethyltin results in increased activity of TRP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

triphenylstannane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

ISO

[triphenyltin chloride results in increased abundance of triphenyltin] which results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

actin, beta

decreases expression

ISO

triphenyltin analog results in decreased expression of ACTB protein

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

angiotensin II receptor, type 1a

increases expression

EXP

triphenyltin results in increased expression of AGTR1 mRNA; triphenyltin results in increased expression of AGTR1 protein

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

EXP
ISO

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the phosphorylation of AKT1 protein
triphenyltin results in decreased phosphorylation of AKT1 protein

PMID:30772500 PMID:31765896

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the phosphorylation of AKT2 protein

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

aldolase, fructose-bisphosphate A

decreases expression

ISO

triphenyltin analog results in decreased expression of ALDOA protein

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

alkaline phosphatase, biomineralization associated

decreases expression

ISO

triphenyltin results in decreased expression of ALPL protein

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

anti-Mullerian hormone

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of AMH mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of AMH protein

NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867

G

annexin A2

decreases expression

ISO

triphenyltin analog results in decreased expression of ANXA2 protein

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

annexin A5

decreases expression

ISO

triphenyltin analog results in decreased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

BCL2, apoptosis regulator

decreases expression

ISO

triphenyltin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

complement C8 gamma chain

multiple interactions
affects binding

ISO

tributyltin inhibits the reaction [triphenyltin binds to C8G protein]
C8G protein binds to triphenyltin
[dibutyldichlorotin results in increased abundance of di-n-butyltin] affects the reaction [C8G protein binds to triphenyltin]; [diphenyltin chloride results in increased abundance of diphenyltin] affects the reaction [C8G protein binds to triphenyltin]; tributyltin inhibits the reaction [C8G protein binds to triphenyltin]; triphenyllead chloride inhibits the reaction [C8G protein binds to triphenyltin]

PMID:32879257 PMID:38614317

NCBI chr 3:28,718,648...28,720,232

G

calmodulin 1

multiple interactions

EXP

CALM1 protein inhibits the reaction [triphenyltin results in decreased activity of NOS1 protein]; triphenyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calreticulin

increases expression

ISO

triphenyltin analog results in increased expression of CALR protein

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

coiled-coil domain containing 154

decreases expression

ISO

triphenyltin analog results in decreased expression of CCDC154 protein

NCBI chr10:14,681,938...14,691,757
Ensembl chr10:14,681,923...14,691,759

G

C-C motif chemokine ligand 2

increases expression

ISO

triphenyltin results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

chaperonin containing TCP1 subunit 3

decreases expression

ISO

triphenyltin analog results in decreased expression of CCT3 protein

NCBI chr 2:176,063,529...176,088,180
Ensembl chr 2:176,063,526...176,089,925

G

CD14 molecule

increases expression

ISO

triphenyltin results in increased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD44 molecule

decreases expression

ISO

triphenyltin analog results in decreased expression of CD44 protein

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd70 molecule

decreases expression

ISO

triphenyltin analog results in decreased expression of CD70 protein

NCBI chr 9:2,093,540...2,096,692
Ensembl chr 9:2,086,848...2,096,692

G

colony stimulating factor 3 receptor

increases expression

ISO

triphenyltin results in increased expression of CSF3R mRNA

NCBI chr 5:143,583,126...143,604,382
Ensembl chr 5:143,583,213...143,602,411

G

C-X-C motif chemokine ligand 12

decreases expression

EXP
ISO

triphenyltin results in decreased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

cytochrome b-245 alpha chain

increases expression

ISO

triphenyltin results in increased expression of CYBA protein

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of CYP11A1 mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of CYP11A1 protein
triphenyltin results in decreased expression of CYP11A1 mRNA; triphenyltin results in decreased expression of CYP11A1 protein

PMID:30772500 PMID:31765896 PMID:35489455

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 11, subfamily b, polypeptide 2

decreases expression

EXP
ISO

triphenyltin results in decreased expression of CYP11B1 mRNA; triphenyltin results in decreased expression of CYP11B1 protein

PMID:29549738 PMID:31765896

NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

ISO

triphenyltin results in increased expression of CYP11B2 mRNA

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of CYP17A1 mRNA

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects activity
decreases expression

EXP
ISO

triphenyltin affects the activity of CYP19A1 protein
triphenyltin results in decreased expression of CYP19A1 mRNA

PMID:20708649 PMID:29549738

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 21, subfamily a, polypeptide 1

decreases expression

EXP

triphenyltin results in decreased expression of CYP21A1 mRNA

NCBI chr20:4,028,323...4,031,549
Ensembl chr20:4,028,391...4,031,543

G

DEAD-box helicase 4

decreases expression

EXP

triphenyltin results in decreased expression of DDX4 mRNA

NCBI chr 2:45,961,174...46,016,097
Ensembl chr 2:45,961,174...46,015,951

G

desmin

decreases expression

ISO

triphenyltin analog results in decreased expression of DES protein

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

desert hedgehog signaling molecule

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of DHH mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of DHH protein

NCBI chr 7:131,929,857...131,935,352
Ensembl chr 7:131,929,857...131,935,352

G

dentin matrix acidic phosphoprotein 1

decreases expression

ISO

triphenyltin results in decreased expression of DMP1 mRNA

NCBI chr14:5,833,111...5,867,154
Ensembl chr14:5,833,111...5,843,993

G

eukaryotic translation elongation factor 1 alpha 1

decreases expression

ISO

triphenyltin analog results in decreased expression of EEF1A1 protein

NCBI chr 8:88,221,839...88,225,688
Ensembl chr 8:88,221,843...88,225,072

G

enolase 1

decreases expression

ISO

triphenyltin analog results in decreased expression of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

ETS variant transcription factor 5

decreases expression

EXP
ISO

triphenyltin results in decreased expression of ETV5 mRNA

NCBI chr11:92,113,171...92,170,758
Ensembl chr11:92,113,224...92,170,767

G

fatty acid binding protein 4

increases expression

ISO

triphenyltin results in increased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fibroblast growth factor 2

decreases expression

ISO
EXP

triphenyltin results in decreased expression of FGF2 mRNA

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

filamin A

decreases expression

ISO

triphenyltin analog results in decreased expression of FLNA protein

NCBI chr X:157,159,051...157,185,559
Ensembl chr X:157,159,051...157,182,343

G

follicle stimulating hormone receptor

multiple interactions
decreases expression

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of FSHR mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of FSHR protein
triphenyltin results in decreased expression of FSHR mRNA

PMID:30772500 PMID:35489455

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

ISO

triphenyltin analog results in decreased expression of GAPDH protein

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

glial cell derived neurotrophic factor

decreases expression

ISO
EXP

triphenyltin results in decreased expression of GDNF mRNA

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240

G

HCK proto-oncogene, Src family tyrosine kinase

increases expression

ISO

triphenyltin results in increased expression of HCK protein

NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

EXP

triphenyltin results in decreased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

EXP

triphenyltin results in decreased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases expression

ISO

triphenyltin analog results in increased expression of HNRNPA2B1 protein

NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions
decreases expression

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of HSD11B1 mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of HSD11B1 protein
triphenyltin results in decreased expression of HSD11B1 mRNA; triphenyltin results in decreased expression of HSD11B1 protein

PMID:30772500 PMID:31765896

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity
increases expression

ISO
EXP

triphenyltin results in decreased activity of HSD11B2 protein
triphenyltin results in increased expression of HSD11B2 mRNA; triphenyltin results in increased expression of HSD11B2 protein

PMID:16184081 PMID:22796344 PMID:31765896

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of HSD17B3 mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of HSD17B3 protein

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

hydroxysteroid (17-beta) dehydrogenase 7

decreases expression

EXP

triphenyltin results in decreased expression of HSD17B7 mRNA

NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions
decreases expression

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of HSD3B1 mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of HSD3B1 protein
triphenyltin results in decreased expression of HSD3B1 mRNA; triphenyltin results in decreased expression of HSD3B1 protein

PMID:30772500 PMID:31765896 PMID:32504733

NCBI chr 2:188,858,574...188,864,694

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases expression

ISO

triphenyltin results in decreased expression of HSD3B2 mRNA

NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569

G

heat shock protein 90 alpha family class A member 1

decreases expression

ISO

triphenyltin analog results in decreased expression of HSP90AA1 protein

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

decreases expression

ISO

triphenyltin analog results in decreased expression of HSP90AB1 protein

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 2

decreases expression

ISO

triphenyltin analog results in decreased expression of HSPA2 protein

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

triphenyltin analog results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family A (Hsp70) member 8

decreases expression

ISO

triphenyltin analog results in decreased expression of HSPA8 protein

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

insulin-like growth factor 1

decreases expression

EXP
ISO

triphenyltin results in decreased expression of IGF1 mRNA

PMID:32504733 PMID:35489455

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

inhibin subunit beta B

decreases expression

EXP
ISO

triphenyltin results in decreased expression of INHBB mRNA

NCBI chr13:33,083,671...33,089,373
Ensembl chr13:33,083,671...33,089,609

G

insulin-like 3

decreases expression

EXP
ISO

triphenyltin results in decreased expression of INSL3 mRNA

NCBI chr16:18,432,668...18,434,539

G

integrin subunit beta 2

increases expression

ISO

triphenyltin results in increased expression of ITGB2 mRNA; triphenyltin results in increased expression of ITGB2 protein

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

keratin 10

increases expression

ISO

triphenyltin analog results in increased expression of KRT10 protein

NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,834,840...84,839,160

G

lactate dehydrogenase B

decreases expression

ISO

triphenyltin analog results in decreased expression of LDHB protein

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

low density lipoprotein receptor

decreases expression

EXP

triphenyltin results in decreased expression of LDLR mRNA; triphenyltin results in decreased expression of LDLR protein

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

luteinizing hormone subunit beta

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of LHCGR mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of LHCGR protein

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061

G

mitogen activated protein kinase 1

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

ISO

triphenyltin results in increased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

marker of proliferation Ki-67

decreases expression

EXP

triphenyltin results in decreased expression of MKI67 mRNA; triphenyltin results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

moesin

increases expression

ISO

triphenyltin analog results in increased expression of MSN protein

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:65,005,458...65,075,129

G

nicotinamide phosphoribosyltransferase

decreases expression

ISO

triphenyltin analog results in decreased expression of NAMPT protein

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

neutrophil cytosolic factor 1

increases expression

ISO

triphenyltin results in increased expression of NCF1 mRNA; triphenyltin results in increased expression of NCF1 protein

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

neutrophil cytosolic factor 2

increases expression

ISO

triphenyltin results in increased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

triphenyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NME/NM23 nucleoside diphosphate kinase 1

decreases expression

ISO

triphenyltin analog results in decreased expression of NME1 protein

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

NME/NM23 nucleoside diphosphate kinase 2

decreases expression

ISO

triphenyltin analog results in decreased expression of NME2 protein

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

nitric oxide synthase 1

multiple interactions
decreases activity

EXP

CALM1 protein inhibits the reaction [triphenyltin results in decreased activity of NOS1 protein]; triphenyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

notch receptor 1

decreases expression

ISO

triphenyltin results in decreased expression of NOTCH1 mRNA

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

nucleophosmin 1

increases expression

ISO

triphenyltin analog results in increased expression of NPM1 protein

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

EXP

triphenyltin results in decreased expression of NR4A1 mRNA; triphenyltin results in decreased expression of NR4A1 protein

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

decreases expression
increases expression

EXP

triphenyltin results in decreased expression of NR4A2 mRNA
triphenyltin results in increased expression of NR4A2 mRNA; triphenyltin results in increased expression of NR4A2 protein

PMID:31765896 PMID:32504733

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

EXP

triphenyltin results in decreased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

EXP

triphenyltin results in decreased expression of NR5A1 mRNA

PMID:32504733 PMID:35489455

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046

G

proliferating cell nuclear antigen

decreases expression

EXP

triphenyltin results in decreased expression of PCNA mRNA; triphenyltin results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

protein disulfide isomerase family A, member 6

increases expression

ISO

triphenyltin analog results in increased expression of PDIA6 protein

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

profilin 1

decreases expression

ISO

triphenyltin analog results in decreased expression of PFN1 protein

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

pyruvate kinase M1/2

decreases expression

ISO

triphenyltin analog results in decreased expression of PKM protein

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

perilipin 1

increases expression

ISO

triphenyltin results in increased expression of PLIN1 mRNA

NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206

G

proopiomelanocortin

decreases expression

EXP

triphenyltin results in decreased expression of POMC protein

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

peroxisome proliferator-activated receptor delta

decreases expression

EXP

triphenyltin results in decreased expression of PPARD mRNA; triphenyltin results in decreased expression of PPARD protein

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression
increases activity
affects binding

ISO
EXP

triphenyltin binds to and results in increased activity of PPARG protein
triphenyltin results in decreased expression of PPARG mRNA
triphenyltin results in increased activity of PPARG protein
triphenyltin binds to PPARG protein

PMID:24786373 PMID:25314719 PMID:25777084 PMID:27725436 PMID:32504733

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

decreases expression

EXP
ISO

triphenyltin results in decreased expression of PPARGC1A protein

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

peroxiredoxin 1

decreases expression

ISO

triphenyltin analog results in decreased expression of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

protein tyrosine phosphatase, non-receptor type 7

decreases expression

ISO

triphenyltin results in decreased expression of PTPN7 mRNA

NCBI chr13:49,122,679...49,136,096
Ensembl chr13:49,122,609...49,136,094

G

retinoid X receptor alpha

increases activity
affects binding
multiple interactions

ISO

triphenyltin results in increased activity of RXRA protein
triphenyltin binds to RXRA protein
triphenylphosphine oxide affects the reaction [triphenyltin binds to RXRA protein]

PMID:27725436 PMID:27894914

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

scavenger receptor class B, member 1

multiple interactions
decreases expression

EXP

[triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of SCARB1 mRNA; [triphenyltin co-treated with ethylene dimethanesulfonate] affects the expression of SCARB1 protein
triphenyltin results in decreased expression of SCARB1 mRNA; triphenyltin results in decreased expression of SCARB1 protein

PMID:30772500 PMID:31765896 PMID:32504733

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sirtuin 1

decreases expression

EXP
ISO

triphenyltin results in decreased expression of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

SRY-box transcription factor 9

increases expression

EXP

triphenyltin results in increased expression of SOX9 mRNA

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

Sp7 transcription factor

decreases expression

ISO

triphenyltin results in decreased expression of SP7 mRNA

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

steroid 5 alpha-reductase 2

decreases activity

ISO

triphenyltin results in decreased activity of SRD5A2 protein

NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[triphenyltin chloride results in increased abundance of triphenyltin] which results in increased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

steroidogenic acute regulatory protein

decreases expression

ISO
EXP

triphenyltin results in decreased expression of STAR mRNA
triphenyltin results in decreased expression of STAR mRNA; triphenyltin results in decreased expression of STAR protein

PMID:29549738 PMID:31765896 PMID:35489455

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

stathmin 1

decreases expression

ISO

triphenyltin analog results in decreased expression of STMN1 protein

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

TNF superfamily member 11

multiple interactions

ISO

triphenyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

tumor protein p53

increases expression

ISO

triphenyltin results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tropomyosin 4

decreases expression

ISO

triphenyltin analog results in decreased expression of TPM4 protein

NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494

G

tubulin, alpha 1A

decreases expression

ISO

triphenyltin analog results in decreased expression of TUBA1A protein

NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035

G

tubulin, beta 1 class VI

increases expression

ISO

triphenyltin analog results in increased expression of TUBB1 protein

NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:183,666,242...183,674,795

G

vimentin

multiple interactions
decreases expression

ISO

[Tretinoin co-treated with triphenyltin analog] results in decreased expression of VIM mRNA; Tretinoin promotes the reaction [triphenyltin analog results in decreased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

WT1 transcription factor

decreases expression

EXP

triphenyltin results in decreased expression of WT1 mRNA

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

ISO

triphenyltin analog results in decreased expression of YWHAB protein

NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

decreases expression

ISO

triphenyltin analog results in decreased expression of YWHAQ protein

NCBI chr 6:46,664,358...46,694,875
Ensembl chr 6:46,664,358...46,694,875

G

zinc finger and BTB domain containing 16

decreases expression

EXP

triphenyltin results in decreased expression of ZBTB16 mRNA

NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507

G

zinc finger AN1-type containing 3

decreases expression

ISO

triphenyltin analog results in decreased expression of ZFAND3 protein

NCBI chr20:8,083,407...8,279,617
Ensembl chr20:8,084,299...8,281,094

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
molecular entity	20859
main group molecular entity	20781
p-block molecular entity	20781
carbon group molecular entity	20715
tin molecular entity	1286
elemental tin +	17
organotin compound +	1279
tin coordination entity +	0
tin hydride +	90
tin oxide +	0
tin(II) chloride (anhydrous) +	14
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
main group molecular entity	20781
p-block molecular entity	20781
carbon group molecular entity	20715
tin molecular entity	1286
elemental tin +	17
organotin compound +	1279
tin coordination entity +	0
tin hydride +	90
tin oxide +	0
tin(II) chloride (anhydrous) +	14

paths to the root