tetraterpenoid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tetraterpenoid	go back to main search page
Accession:	CHEBI:26935	browse the term
Definition:	Any terpenoid derived from a tetraterpene. The term includes compounds in which the C40 skeleton of the parent tetraterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
Synonyms:	exact_synonym:	tetraterpenoids
	related_synonym:	C40 isoprenoids; tetraterpenoides
	xref:	LIPID_MAPS_class:LMPR0107

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Rat (600) Mouse (613) Human (609) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (613)

8'-apo-beta,psi-caroten-8'-al

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-Coenzyme A dehydrogenase, medium chain

increases expression

apocarotenal results in increased expression of ACADM mRNA

NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269

G

alcohol dehydrogenase 5 (class III), chi polypeptide

increases expression

apocarotenal results in increased expression of ADH5 mRNA

NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

apocarotenal results in decreased expression of ALDH1B1 mRNA

NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604

G

aldehyde dehydrogenase 3 family, member B1

decreases expression

apocarotenal results in decreased expression of ALDH3B1 mRNA

NCBI chr19:3,963,491...3,980,898
Ensembl chr19:3,963,491...3,979,808

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

apocarotenal results in decreased expression of ALDH4A1 mRNA

NCBI chr 4:139,348,404...139,377,002
Ensembl chr 4:139,350,177...139,377,001

G

ankyrin 2, brain

increases expression

apocarotenal results in increased expression of ANK2 mRNA

NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999

G

ankyrin 3, epithelial

increases expression

apocarotenal results in increased expression of ANK3 mRNA

NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268

G

N-acylsphingosine amidohydrolase 1

increases expression

apocarotenal results in increased expression of ASAH1 mRNA

NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810

G

ankyrin repeat and SOCS box-containing 1

increases expression

apocarotenal results in increased expression of ASB1 mRNA

NCBI chr 1:91,467,725...91,487,312
Ensembl chr 1:91,468,266...91,487,311

G

ankyrin repeat and SOCS box-containing 9

increases expression

apocarotenal results in increased expression of ASB9 mRNA

NCBI chr X:163,280,899...163,322,748
Ensembl chr X:163,289,323...163,322,748

G

BCL2-associated X protein

decreases expression

apocarotenal results in decreased expression of BAX mRNA

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

beta-carotene oxygenase 2

multiple interactions

[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite

NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481

G

caspase 8 associated protein 2

increases expression

apocarotenal results in increased expression of CASP8AP2 mRNA

NCBI chr 4:32,615,462...32,653,271
Ensembl chr 4:32,615,451...32,653,265

G

cadherin 1

increases expression

apocarotenal results in increased expression of CDH1 mRNA

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

claudin 10

increases expression

apocarotenal results in increased expression of CLDN10 mRNA

NCBI chr14:119,025,283...119,111,937
Ensembl chr14:119,025,320...119,112,901

G

claudin 18

increases expression

apocarotenal results in increased expression of CLDN18 mRNA

NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320

G

collagen, type I, alpha 1

decreases expression

apocarotenal results in decreased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type IV, alpha 1

decreases expression

apocarotenal results in decreased expression of COL4A1 mRNA

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type IV, alpha 2

decreases expression

apocarotenal results in decreased expression of COL4A2 mRNA

NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287

G

cellular retinoic acid binding protein II

decreases expression

apocarotenal results in decreased expression of CRABP2 mRNA

NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683

G

cathepsin B

decreases expression

apocarotenal results in decreased expression of CTSB mRNA

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

C-X-C motif chemokine ligand 12

increases expression

apocarotenal results in increased expression of CXCL12 mRNA

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

C-X-C motif chemokine ligand 5

increases expression

apocarotenal results in increased expression of CXCL6 mRNA

NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483

G

C-X-C motif chemokine ligand 9

increases expression

apocarotenal results in increased expression of CXCL9 mRNA

NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938

G

C-X-C motif chemokine receptor 4

increases expression

apocarotenal results in increased expression of CXCR4 mRNA

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome P450, family 2, subfamily c, polypeptide 65

increases expression

apocarotenal results in increased expression of CYP2C9 mRNA

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

distal-less homeobox 2

increases expression

apocarotenal results in increased expression of DLX2 mRNA

NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098

G

distal-less homeobox 4

increases expression

apocarotenal results in increased expression of DLX4 mRNA

NCBI chr11:95,031,273...95,037,116
Ensembl chr11:95,031,273...95,037,089

G

excision repair cross-complementing rodent repair deficiency, complementation group 2

decreases expression

apocarotenal results in decreased expression of ERCC2 mRNA

NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619

G

E26 avian leukemia oncogene 1, 5' domain

decreases expression

apocarotenal results in decreased expression of ETS1 mRNA

NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116

G

Fas cell surface death receptor

increases expression

apocarotenal results in increased expression of FAS mRNA

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

fatty acid synthase

decreases expression

apocarotenal results in decreased expression of FASN mRNA

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

GATA binding protein 6

increases expression

apocarotenal results in increased expression of GATA6 mRNA

NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635

G

guanylate binding protein 2b

increases expression

apocarotenal results in increased expression of GBP1 mRNA

NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940

G

glutathione S-transferase kappa 1

decreases expression

apocarotenal results in decreased expression of GSTK1 mRNA

NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381

G

glutathione S-transferase, mu 2

decreases expression

apocarotenal results in decreased expression of GSTM2 mRNA

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

glutathione S-transferase, mu 4

decreases expression

apocarotenal results in decreased expression of GSTM4 mRNA

NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210

G

glutathione transferase zeta 1 (maleylacetoacetate isomerase)

decreases expression

apocarotenal results in decreased expression of GSTZ1 mRNA

NCBI chr12:87,192,102...87,211,497
Ensembl chr12:87,193,939...87,211,497

G

homeobox A7

increases expression

apocarotenal results in increased expression of HOXA7 mRNA

NCBI chr 6:52,191,471...52,198,757
Ensembl chr 6:52,191,471...52,198,834

G

homeobox B6

increases expression

apocarotenal results in increased expression of HOXB6 mRNA

NCBI chr11:96,183,647...96,192,395
Ensembl chr11:96,183,302...96,192,395

G

homeobox C10

increases expression

apocarotenal results in increased expression of HOXC10 mRNA

NCBI chr15:102,875,231...102,880,333
Ensembl chr15:102,875,231...102,880,328

G

interferon regulatory factor 8

increases expression

apocarotenal results in increased expression of IRF8 mRNA

NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433

G

Iroquois homeobox 4

decreases expression

apocarotenal results in decreased expression of IRX4 mRNA

NCBI chr13:73,407,708...73,417,741
Ensembl chr13:73,408,598...73,417,727

G

integrin beta 4

decreases expression

apocarotenal results in decreased expression of ITGB4 mRNA

NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238

G

involucrin

increases expression

apocarotenal results in increased expression of IVL mRNA

NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042

G

keratin 17

decreases expression

apocarotenal results in decreased expression of KRT17 mRNA

NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855

G

keratin 2

increases expression

apocarotenal results in increased expression of KRT2 mRNA

NCBI chr15:101,719,124...101,727,391
Ensembl chr15:101,719,124...101,726,604

G

keratin 7

affects expression

apocarotenal affects the expression of KRT7 mRNA

NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194

G

LIM homeobox protein 3

increases expression

apocarotenal results in increased expression of LHX3 mRNA

NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301

G

myeloid cell leukemia sequence 1

affects expression

apocarotenal affects the expression of MCL1 mRNA

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

Meis homeobox 2

increases expression

apocarotenal results in increased expression of MEIS2 mRNA

NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320

G

mesenchyme homeobox 1

increases expression

apocarotenal results in increased expression of MEOX1 mRNA

NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200

G

motor neuron and pancreas homeobox 1

increases expression

apocarotenal results in increased expression of MNX1 mRNA

NCBI chr 5:29,678,821...29,683,468
Ensembl chr 5:29,678,032...29,683,468

G

mutS homolog 5

increases expression

apocarotenal results in increased expression of MSH5 mRNA

NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721

G

mucin 5, subtypes A and C, tracheobronchial/gastric

increases expression

apocarotenal results in increased expression of MUC5AC mRNA

NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968

G

nitric oxide synthase 1, neuronal

increases expression

apocarotenal results in increased expression of NOS1 mRNA

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

oxidized low density lipoprotein (lectin-like) receptor 1

increases expression

apocarotenal results in increased expression of OLR1 mRNA

NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128

G

protocadherin gamma subfamily C, 3

increases expression

apocarotenal results in increased expression of PCDHGC3 mRNA

NCBI chr18:37,939,463...37,974,926
Ensembl chr18:37,939,417...37,974,926

G

phospholipid scramblase 1

increases expression

apocarotenal results in increased expression of PLSCR1 mRNA

NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331

G

phospholipid scramblase 3

increases expression

apocarotenal results in increased expression of PLSCR3 mRNA

NCBI chr11:69,734,937...69,742,884
Ensembl chr11:69,737,202...69,742,884

G

phospholipid scramblase 4

increases expression

apocarotenal results in increased expression of PLSCR4 mRNA

NCBI chr 9:92,339,431...92,374,509
Ensembl chr 9:92,339,426...92,374,509

G

RAD51 associated protein 1

increases expression

apocarotenal results in increased expression of RAD51AP1 mRNA

NCBI chr 6:126,900,378...126,916,664
Ensembl chr 6:126,900,013...126,916,550

G

RAD51 paralog D

increases expression

apocarotenal results in increased expression of RAD51D mRNA

NCBI chr11:82,762,786...82,781,571
Ensembl chr11:82,767,260...82,781,440

G

retinoic acid receptor, alpha

decreases expression

apocarotenal results in decreased expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

retinoic acid receptor, beta

increases expression

apocarotenal results in increased expression of RARB mRNA

NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924

G

retinoic acid receptor responder (tazarotene induced) 1

increases expression

apocarotenal results in increased expression of RARRES1 mRNA

NCBI chr 3:67,386,219...67,422,856
Ensembl chr 3:67,386,305...67,422,856

G

sine oculis-related homeobox 6

increases expression

apocarotenal results in increased expression of SIX6 mRNA

NCBI chr12:72,986,656...72,991,673
Ensembl chr12:72,986,666...72,991,673

G

superoxide dismutase 1, soluble

decreases expression

apocarotenal results in decreased expression of SOD1 mRNA

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

serine palmitoyltransferase, long chain base subunit 2

affects expression

apocarotenal affects the expression of SPTLC2 mRNA

NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129

G

sterol regulatory element binding transcription factor 1

increases expression

apocarotenal results in increased expression of SREBF1 mRNA

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

transglutaminase 4 (prostate)

increases expression

apocarotenal results in increased expression of TGM4 mRNA

NCBI chr 9:122,863,806...122,896,623
Ensembl chr 9:122,863,791...122,896,626

G

tumor necrosis factor receptor superfamily, member 9

increases expression

apocarotenal results in increased expression of TNFRSF9 mRNA

NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559

G

tumor necrosis factor (ligand) superfamily, member 10

increases expression

apocarotenal results in increased expression of TNFSF10 mRNA

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

thioredoxin domain containing 9

increases expression

apocarotenal results in increased expression of TXNDC9 mRNA

NCBI chr 1:38,022,385...38,036,324
Ensembl chr 1:38,024,270...38,036,974

G

X-ray repair complementing defective repair in Chinese hamster cells 3

increases expression

apocarotenal results in increased expression of XRCC3 mRNA

NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307

9'-cis-neoxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-inducing factor, mitochondrion-associated 1

affects localization

neoxanthin affects the localization of AIFM1 protein

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

caspase 3

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases activity

neoxanthin results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

all-trans-neoxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-inducing factor, mitochondrion-associated 1

affects localization

neoxanthin affects the localization of AIFM1 protein

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

caspase 3

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases activity

neoxanthin results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

alpha-carotene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

O-6-methylguanine-DNA methyltransferase

affects response to substance

MGMT gene SNP affects the susceptibility to alpha-carotene

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

astaxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-inducing factor, mitochondrion-associated 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

thymoma viral proto-oncogene 1

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

multiple interactions

astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein]

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

amyloid beta precursor protein

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

arginase, liver

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of ARG1 mRNA]

NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382

G

autophagy related 12

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG12 mRNA]

NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647

G

autophagy related 14

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG14 mRNA]

NCBI chr14:47,778,350...47,805,891
Ensembl chr14:47,778,350...47,808,106

G

BCL2-associated X protein

multiple interactions

astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

beclin 1, autophagy related

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 mRNA]; astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 protein]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

complement component 1, q subcomponent, alpha polypeptide

decreases expression

astaxanthine results in decreased expression of C1QA mRNA

NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114

G

caspase 3

multiple interactions

astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]
astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein]

PMID:16964424 PMID:34564187

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cyclin N-terminal domain containing 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]

NCBI chr11:101,170,029...101,179,527
Ensembl chr11:101,169,838...101,187,143

G

collagen, type II, alpha 1

multiple interactions

astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]

NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576

G

cytochrome c oxidase assembly protein 15

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]

NCBI chr19:43,721,693...43,741,439
Ensembl chr19:43,721,693...43,741,439

G

cytochrome c oxidase subunit 5A

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]

NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709

G

cytochrome c oxidase subunit 5B

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]

NCBI chr 1:36,730,568...36,732,469
Ensembl chr 1:36,730,530...36,732,762

G

cytochrome c oxidase, subunit 6B1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]

NCBI chr 7:30,316,396...30,325,539
Ensembl chr 7:30,316,286...30,325,576

G

cytochrome c oxidase subunit 6C

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]

NCBI chr15:35,932,122...35,938,392
Ensembl chr15:35,926,032...35,938,392

G

component of Sp100-rs

decreases expression

astaxanthine results in decreased expression of CSPRS mRNA

G

cathepsin S

decreases expression

astaxanthine results in decreased expression of CTSS mRNA

NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714

G

cytochrome b-245, beta polypeptide

multiple interactions
decreases expression

astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]
astaxanthine results in decreased expression of CYBB mRNA

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

forkhead box O3

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]

NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751

G

glucose-6-phosphate dehydrogenase X-linked

increases activity
multiple interactions

astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein

PMID:28665548 PMID:29975440

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

glial fibrillary acidic protein

decreases expression

astaxanthine results in decreased expression of GFAP mRNA

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gap junction protein, alpha 1

increases expression
multiple interactions

astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

guanine nucleotide binding protein, alpha 13

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]

NCBI chr11:109,253,620...109,292,195
Ensembl chr11:109,253,657...109,292,195

G

glutamic pyruvic transaminase, soluble

multiple interactions

astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 3

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutathione peroxidase 4

multiple interactions
increases expression

astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]
astaxanthine results in increased expression of GPX4 protein
astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein]

PMID:36084724 PMID:37648051

NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

multiple interactions

[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

granulin

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]

NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874

G

glutathione reductase

multiple interactions

astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein]

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, mu 2

multiple interactions
increases expression

[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

high mobility group box 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]
astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA]

PMID:16964424 PMID:34564187

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

heme oxygenase 1

increases expression
multiple interactions
decreases expression

astaxanthine results in increased expression of HMOX1 protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]

PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

homeobox A9

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]

NCBI chr 6:52,200,077...52,203,169
Ensembl chr 6:52,200,080...52,208,069

G

isocitrate dehydrogenase 1 (NADP+), soluble

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]

NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659

G

interferon gamma

increases expression

astaxanthine results in increased expression of IFNG protein

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 10

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of IL10 mRNA]
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein]

PMID:33008094 PMID:34564187

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 11

increases expression

astaxanthine results in increased expression of IL11 protein

NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858

G

interleukin 1 beta

decreases expression
multiple interactions

astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of P53 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein]
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]

PMID:21621527 PMID:33008094 PMID:34564187 PMID:36084724

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

decreases expression
multiple interactions

astaxanthine results in decreased expression of IL6 mRNA
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL6 mRNA]

PMID:21621527 PMID:33008094

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

decreases expression

astaxanthine results in decreased expression of INS1 protein

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

leptin receptor

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

mitogen-activated protein kinase 1

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK8 protein]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

matrix metallopeptidase 13

multiple interactions

astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

NADH dehydrogenase 6, mitochondrial

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]

NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070

G

NADH:ubiquinone oxidoreductase subunit A1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]

NCBI chr X:36,451,241...36,454,891
Ensembl chr X:36,451,241...36,454,816

G

NADH:ubiquinone oxidoreductase subunit A5

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]

NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012

G

NADH:ubiquinone oxidoreductase subunit C2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]

NCBI chr 7:97,049,210...97,057,007
Ensembl chr 7:97,049,210...97,057,009

G

NADH:ubiquinone oxidoreductase core subunit V2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]

NCBI chr17:66,385,790...66,408,554
Ensembl chr17:66,385,633...66,408,554

G

nuclear factor, erythroid derived 2, like 2

increases expression
multiple interactions

astaxanthine results in increased expression of NFE2L2 protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA; astaxanthine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]

PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]

NCBI chr11:93,840,640...93,847,082
Ensembl chr11:93,840,640...93,847,085

G

nitric oxide synthase 2, inducible

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 protein]
astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA]

PMID:33008094 PMID:34564187 PMID:36084724

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases expression

[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of NQO1 mRNA]
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein

PMID:20038455 PMID:24157545 PMID:33212048

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

phenylalanine hydroxylase

decreases expression

astaxanthine results in decreased expression of PAH mRNA

NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998

G

phosphogluconate dehydrogenase

increases activity

astaxanthine results in increased activity of PGD protein

PMID:28665548 PMID:29975440

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

cytochrome p450 oxidoreductase

decreases activity
increases expression

astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein

NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180

G

protein phosphatase 1 catalytic subunit beta

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]

NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777

G

peroxiredoxin 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]

NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019

G

phosphatase and tensin homolog

multiple interactions

astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA]

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

astaxanthine results in decreased expression of PTGS2 mRNA
astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PTGS2 mRNA]

PMID:21621527 PMID:33008094 PMID:36084724

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ribosomal protein S2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]

NCBI chr17:24,939,037...24,940,901
Ensembl chr17:24,937,090...24,940,903

G

src family associated phosphoprotein 2

decreases expression

astaxanthine results in decreased expression of SKAP2 mRNA

NCBI chr 6:51,836,145...51,989,529
Ensembl chr 6:51,834,402...51,989,529

G

superoxide dismutase 1, soluble

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

trans-acting transcription factor 1

multiple interactions

[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

secreted phosphoprotein 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

transglutaminase 2, C polypeptide

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]

NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356

G

transketolase

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]

NCBI chr14:30,271,088...30,296,681
Ensembl chr14:30,270,316...30,296,677

G

toll-like receptor 2

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR2 mRNA]

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

toll-like receptor 4

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 mRNA]

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

astaxanthine results in decreased expression of TNF protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA]
astaxanthine results in increased expression of TNF protein

PMID:21621527 PMID:33008094 PMID:33132140

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

triggering receptor expressed on myeloid cells 2

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TREM2 mRNA]

NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175

G

transformation related protein 53

multiple interactions

astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein]

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

ubiquitin B

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]

NCBI chr11:62,442,329...62,444,037
Ensembl chr11:62,441,997...62,444,039

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]

NCBI chr13:67,048,640...67,053,414
Ensembl chr13:67,048,681...67,053,442

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]

NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747

beta-carotene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-Coenzyme A dehydrogenase family, member 9

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA

NCBI chr 3:36,120,128...36,147,006
Ensembl chr 3:36,120,128...36,147,002

G

alcohol dehydrogenase 5 (class III), chi polypeptide

increases expression

beta Carotene results in increased expression of ADH5 mRNA

NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260

G

adiponectin, C1Q and collagen domain containing

decreases expression

beta Carotene results in decreased expression of ADIPOQ mRNA

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

AE binding protein 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA

NCBI chr11:5,806,085...5,822,248
Ensembl chr11:5,811,947...5,822,088

G

thymoma viral proto-oncogene 1

decreases phosphorylation
decreases expression

beta Carotene results in decreased phosphorylation of AKT1 protein
beta Carotene results in decreased expression of AKT1 mRNA

PMID:26733226 PMID:36819991

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aminolevulinate, delta-, dehydratase

multiple interactions

beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein]

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

aldehyde dehydrogenase 3 family, member B1

decreases expression

beta Carotene results in decreased expression of ALDH3B1 mRNA

NCBI chr19:3,963,491...3,980,898
Ensembl chr19:3,963,491...3,979,808

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

beta Carotene results in decreased expression of ALDH4A1 mRNA

NCBI chr 4:139,348,404...139,377,002
Ensembl chr 4:139,350,177...139,377,001

G

ankyrin 2, brain

increases expression

beta Carotene results in increased expression of ANK2 mRNA

NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999

G

ankyrin 3, epithelial

increases expression

beta Carotene results in increased expression of ANK3 mRNA

NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268

G

amyloid beta precursor protein binding protein 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA

NCBI chr11:85,082,134...85,125,946
Ensembl chr11:85,078,088...85,125,956

G

Rho GTPase activating protein 26

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA

NCBI chr18:38,734,531...39,509,338
Ensembl chr18:39,126,198...39,509,337
Ensembl chr18:39,126,198...39,509,337

G

N-acylsphingosine amidohydrolase 1

increases expression

beta Carotene results in increased expression of ASAH1 mRNA

NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810

G

ankyrin repeat and SOCS box-containing 1

increases expression

beta Carotene results in increased expression of ASB1 mRNA

NCBI chr 1:91,467,725...91,487,312
Ensembl chr 1:91,468,266...91,487,311

G

ankyrin repeat and SOCS box-containing 9

increases expression

beta Carotene results in increased expression of ASB9 mRNA

NCBI chr X:163,280,899...163,322,748
Ensembl chr X:163,289,323...163,322,748

G

ATPase, class I, type 8B, member 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA

NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338

G

BCL2-associated athanogene 3

decreases expression

beta Carotene results in decreased expression of BAG3 mRNA

NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705

G

BCL2-associated athanogene 4

decreases expression

beta Carotene results in decreased expression of BAG4 mRNA

NCBI chr 8:26,254,566...26,275,237
Ensembl chr 8:26,254,566...26,275,315

G

BCL2-associated athanogene 5

decreases expression

beta Carotene results in decreased expression of BAG5 mRNA

NCBI chr12:111,675,922...111,679,690
Ensembl chr12:111,675,922...111,679,691

G

BCL2-associated X protein

decreases expression
increases expression

beta Carotene results in decreased expression of BAX mRNA
beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein

PMID:15949688 PMID:17034753 PMID:26733226

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

beta Carotene results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

beta-carotene oxygenase 1

multiple interactions
affects response to substance
increases oxidation
increases expression

beta Carotene results in increased expression of and results in increased activity of BCO1 protein
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA
BCO1 protein results in increased oxidation of beta Carotene
beta Carotene results in increased expression of BCO1 mRNA
Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]

PMID:9526112 PMID:16186334 PMID:24657404

NCBI chr 8:117,822,590...117,860,459
Ensembl chr 8:117,822,593...117,860,459

G

beta-carotene oxygenase 2

multiple interactions
increases metabolic processing

[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal

NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481

G

caspase 3

multiple interactions
increases activity

alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]
beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein

PMID:17618090 PMID:26733226

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions

[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]

PMID:9306888 PMID:12500499 PMID:25542264 PMID:31022331

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

decreases expression

beta Carotene results in decreased expression of CAV1 protein

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

cyclin D1

decreases expression

beta Carotene results in decreased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cell division cycle associated 8

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA

NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104

G

cadherin 1

increases expression

beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein

PMID:17034753 PMID:26733226

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

CCAAT/enhancer binding protein alpha

decreases expression

beta Carotene results in decreased expression of CEBPA mRNA

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

centromere protein E

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA

NCBI chr 3:134,918,324...134,979,301
Ensembl chr 3:134,918,298...134,979,372

G

CASP8 and FADD-like apoptosis regulator

increases expression

beta Carotene results in increased expression of CFLAR mRNA

NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043

G

chloride channel, voltage-sensitive 3

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA

NCBI chr 8:61,363,423...61,436,351
Ensembl chr 8:61,363,423...61,436,334

G

claudin 10

increases expression

beta Carotene results in increased expression of CLDN10 mRNA

NCBI chr14:119,025,283...119,111,937
Ensembl chr14:119,025,320...119,112,901

G

claudin 18

increases expression

beta Carotene results in increased expression of CLDN18 mRNA

NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320

G

collagen, type I, alpha 1

decreases expression

beta Carotene results in decreased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type IV, alpha 1

decreases expression

beta Carotene results in decreased expression of COL4A1 mRNA

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type IV, alpha 2

decreases expression

beta Carotene results in decreased expression of COL4A2 mRNA

NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287

G

demethyl-Q 7

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA

NCBI chr 7:118,108,881...118,132,529
Ensembl chr 7:118,108,882...118,132,579

G

carnitine palmitoyltransferase 1b, muscle

decreases expression

beta Carotene results in decreased expression of CPT1B mRNA

NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066

G

CASP2 and RIPK1 domain containing adaptor with death domain

increases expression

beta Carotene results in increased expression of CRADD mRNA

NCBI chr10:95,010,601...95,160,000
Ensembl chr10:95,010,608...95,159,995

G

catenin alpha like 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA

NCBI chr 4:56,810,935...56,865,370
Ensembl chr 4:56,810,935...56,865,188

G

cathepsin B

decreases expression

beta Carotene results in decreased expression of CTSB mRNA

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

C-X-C motif chemokine ligand 12

increases expression

beta Carotene results in increased expression of CXCL12 mRNA

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

C-X-C motif chemokine ligand 15

multiple interactions

beta Carotene promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 5

increases expression

beta Carotene results in increased expression of CXCL6 mRNA

NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483

G

C-X-C motif chemokine ligand 9

increases expression

beta Carotene results in increased expression of CXCL9 mRNA

NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938

G

C-X-C motif chemokine receptor 4

increases expression

beta Carotene results in increased expression of CXCR4 mRNA

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]]

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

beta Carotene results in increased expression of CYP26A1 mRNA

PMID:16186334 PMID:22542753

NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984

G

cytochrome P450, family 2, subfamily c, polypeptide 65

increases expression

beta Carotene results in increased expression of CYP2C9 mRNA

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

dihydrofolate reductase

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA

NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561

G

distal-less homeobox 2

increases expression

beta Carotene results in increased expression of DLX2 mRNA

NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098

G

distal-less homeobox 4

increases expression

beta Carotene results in increased expression of DLX4 mRNA

NCBI chr11:95,031,273...95,037,116
Ensembl chr11:95,031,273...95,037,089

G

dipeptidylpeptidase 4

multiple interactions

[Xiao-Ke-An results in increased abundance of beta Carotene] which results in decreased activity of DPP4 protein

NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575

G

DTW domain containing 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA

NCBI chr18:49,829,212...49,890,255
Ensembl chr18:49,829,212...49,888,668

G

endothelin 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

eukaryotic translation initiation factor 2, subunit 1 alpha

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

excision repair cross-complementing rodent repair deficiency, complementation group 2

decreases expression

beta Carotene results in decreased expression of ERCC2 mRNA

NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619

G

estrogen receptor 1 (alpha)

multiple interactions

beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA]

PMID:17051425 PMID:19340624

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen receptor 2 (beta)

multiple interactions

beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein]

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

fatty acid binding protein 4, adipocyte

decreases expression

beta Carotene results in decreased expression of FABP4 mRNA

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

Fas apoptotic inhibitory molecule 2

increases expression

beta Carotene results in increased expression of FAIM2 mRNA

NCBI chr15:99,394,886...99,432,757
Ensembl chr15:99,394,893...99,426,046

G

Fas cell surface death receptor

increases expression

beta Carotene results in increased expression of FAS mRNA

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

fos-like antigen 1

increases expression

beta Carotene results in increased expression of FOSL1 protein

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

G

forkhead box A1

increases expression

beta Carotene results in increased expression of FOXA1 mRNA

NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702

G

forkhead box M1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA

NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109

G

frizzled class receptor 6

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA

NCBI chr15:38,869,673...38,901,587
Ensembl chr15:38,869,429...38,901,583

G

GATA binding protein 6

increases expression

beta Carotene results in increased expression of GATA6 mRNA

NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635

G

guanylate binding protein 2b

increases expression

beta Carotene results in increased expression of GBP1 mRNA

NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940

G

gap junction protein, alpha 1

multiple interactions
increases expression

beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]
beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]

PMID:16091010 PMID:27154496

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

glutathione reductase

multiple interactions

beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein]

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase kappa 1

decreases expression

beta Carotene results in decreased expression of GSTK1 mRNA

NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381

G

glutathione S-transferase, mu 2

increases expression

beta Carotene results in increased expression of GSTM2 mRNA

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

glutathione S-transferase, mu 4

decreases expression

beta Carotene results in decreased expression of GSTM4 mRNA

NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210

G

glutathione transferase zeta 1 (maleylacetoacetate isomerase)

decreases expression

beta Carotene results in decreased expression of GSTZ1 mRNA

NCBI chr12:87,192,102...87,211,497
Ensembl chr12:87,193,939...87,211,497

G

homeobox A7

increases expression

beta Carotene results in increased expression of HOXA7 mRNA

NCBI chr 6:52,191,471...52,198,757
Ensembl chr 6:52,191,471...52,198,834

G

homeobox B6

increases expression

beta Carotene results in increased expression of HOXB6 mRNA

NCBI chr11:96,183,647...96,192,395
Ensembl chr11:96,183,302...96,192,395

G

homeobox C10

increases expression

beta Carotene results in increased expression of HOXC10 mRNA

NCBI chr15:102,875,231...102,880,333
Ensembl chr15:102,875,231...102,880,328

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions

beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]

NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536

G

insulin-like growth factor binding protein 5

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA

NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043

G

interleukin 1 beta

multiple interactions

beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interferon regulatory factor 8

increases expression

beta Carotene results in increased expression of IRF8 mRNA

NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433

G

Iroquois homeobox 4

decreases expression
multiple interactions

beta Carotene results in decreased expression of IRX4 mRNA
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA

PMID:17034753 PMID:24657404

NCBI chr13:73,407,708...73,417,741
Ensembl chr13:73,408,598...73,417,727

G

integrin beta 1 (fibronectin receptor beta)

decreases expression

beta Carotene results in decreased expression of ITGB1 mRNA

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

integrin beta 4

decreases expression

beta Carotene results in decreased expression of ITGB4 mRNA

NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238

G

integral membrane protein 2A

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA

NCBI chr X:106,440,801...106,446,966
Ensembl chr X:106,440,705...106,446,982

G

involucrin

increases expression

beta Carotene results in increased expression of IVL mRNA

NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042

G

jun proto-oncogene

increases expression

beta Carotene results in increased expression of JUN protein

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

kinesin family member 11

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA

NCBI chr19:37,364,830...37,410,311
Ensembl chr19:37,364,851...37,410,307

G

keratin 18

increases expression

beta Carotene results in increased expression of KRT18 mRNA

NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462

G

keratin 19

increases expression

beta Carotene results in increased expression of KRT19 mRNA

NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491

G

keratin 2

increases expression

beta Carotene results in increased expression of KRT2 mRNA

NCBI chr15:101,719,124...101,727,391
Ensembl chr15:101,719,124...101,726,604

G

keratin 7

affects expression

beta Carotene affects the expression of KRT7 mRNA

NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194

G

keratin 8

decreases expression

beta Carotene results in decreased expression of KRT8 mRNA

NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917

G

LanC (bacterial lantibiotic synthetase component C)-like 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA

NCBI chr 1:67,039,676...67,078,049
Ensembl chr 1:67,039,676...67,078,031

G

LIM homeobox protein 3

increases expression

beta Carotene results in increased expression of LHX3 mRNA

NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301

G

lamin B2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA

NCBI chr10:80,737,197...80,754,079
Ensembl chr10:80,737,037...80,754,079

G

lipoprotein lipase

decreases expression

beta Carotene results in decreased expression of LPL mRNA

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

beta Carotene results in increased phosphorylation of MAPK1 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

PMID:16206275 PMID:27154496

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

beta Carotene results in increased phosphorylation of MAPK3 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

PMID:16206275 PMID:27154496

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mannose-binding lectin (protein C) 2

multiple interactions

MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene]

NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087

G

myeloid cell leukemia sequence 1

affects expression

beta Carotene affects the expression of MCL1 mRNA

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

Meis homeobox 2

increases expression

beta Carotene results in increased expression of MEIS2 mRNA

NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320

G

mesenchyme homeobox 1

increases expression

beta Carotene results in increased expression of MEOX1 mRNA

NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200

G

methyltransferase 21A, HSPA lysine

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA

NCBI chr 1:64,645,632...64,661,926
Ensembl chr 1:64,645,632...64,656,401

G

methyltransferase like 9

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA

NCBI chr 7:120,631,717...120,676,058
Ensembl chr 7:120,633,668...120,677,552

G

O-6-methylguanine-DNA methyltransferase

affects response to substance

MGMT gene SNP affects the susceptibility to beta Carotene

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

antigen identified by monoclonal antibody Ki 67

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

motor neuron and pancreas homeobox 1

increases expression

beta Carotene results in increased expression of MNX1 mRNA

NCBI chr 5:29,678,821...29,683,468
Ensembl chr 5:29,678,032...29,683,468

G

myeloperoxidase

multiple interactions

[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

mitochondrial ribosomal protein L57

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA

NCBI chr14:58,063,662...58,066,544
Ensembl chr14:58,063,691...58,066,753

G

mutS homolog 5

increases expression

beta Carotene results in increased expression of MSH5 mRNA

NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721

G

mitochondrial carrier 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA

NCBI chr 2:90,677,434...90,697,154
Ensembl chr 2:90,677,499...90,697,154

G

mucin 5, subtypes A and C, tracheobronchial/gastric

increases expression

beta Carotene results in increased expression of MUC5AC mRNA

NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968

G

NCK-associated protein 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA

NCBI chr 2:80,330,856...80,411,526
Ensembl chr 2:80,330,856...80,411,724

G

nucleolar protein with MIF4G domain 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA

NCBI chr 5:29,637,338...29,658,504
Ensembl chr 5:29,639,662...29,662,841

G

nitric oxide synthase 1, neuronal

increases expression

beta Carotene results in increased expression of NOS1 mRNA

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 2, inducible

multiple interactions

[Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
beta Carotene results in increased activity of NR1I2 protein

PMID:15949683 PMID:16632523

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

oxidized low density lipoprotein (lectin-like) receptor 1

increases expression

beta Carotene results in increased expression of OLR1 mRNA

NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128

G

par-6 family cell polarity regulator alpha

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA

NCBI chr 8:106,427,780...106,430,126
Ensembl chr 8:106,427,780...106,430,128

G

protocadherin 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA

NCBI chr18:38,318,967...38,345,023
Ensembl chr18:38,318,967...38,345,106

G

protocadherin gamma subfamily C, 3

increases expression

beta Carotene results in increased expression of PCDHGC3 mRNA

NCBI chr18:37,939,463...37,974,926
Ensembl chr18:37,939,417...37,974,926

G

platelet derived growth factor receptor, beta polypeptide

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

phosphoinositide-3-kinase regulatory subunit 5

increases expression

beta Carotene results in increased expression of PIK3R5 protein

NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675

G

plasminogen activator, tissue

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

phospholipid scramblase 1

increases expression

beta Carotene results in increased expression of PLSCR1 mRNA

NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331

G

phospholipid scramblase 3

increases expression

beta Carotene results in increased expression of PLSCR3 mRNA

NCBI chr11:69,734,937...69,742,884
Ensembl chr11:69,737,202...69,742,884

G

phospholipid scramblase 4

increases expression

beta Carotene results in increased expression of PLSCR4 mRNA

NCBI chr 9:92,339,431...92,374,509
Ensembl chr 9:92,339,426...92,374,509

G

peroxisome proliferator activated receptor alpha

decreases expression

beta Carotene results in decreased expression of PPARA mRNA

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activated receptor gamma

decreases expression

beta Carotene results in decreased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

prolactin family 2, subfamily c, member 3

increases expression

beta Carotene results in increased expression of PRL2C3 protein

NCBI chr13:12,805,705...12,814,982
Ensembl chr13:12,805,705...12,814,968

G

RAD51 associated protein 1

decreases expression

beta Carotene results in decreased expression of RAD51AP1 mRNA

NCBI chr 6:126,900,378...126,916,664
Ensembl chr 6:126,900,013...126,916,550

G

RAD51 paralog D

increases expression

beta Carotene results in increased expression of RAD51D mRNA

NCBI chr11:82,762,786...82,781,571
Ensembl chr11:82,767,260...82,781,440

G

retinoic acid receptor, alpha

decreases expression

beta Carotene results in decreased expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

retinoic acid receptor, beta

increases expression

beta Carotene results in increased expression of RARB mRNA

NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924

G

retinoic acid receptor responder (tazarotene induced) 1

increases expression

beta Carotene results in increased expression of RARRES1 mRNA

NCBI chr 3:67,386,219...67,422,856
Ensembl chr 3:67,386,305...67,422,856

G

retinol binding protein 4, plasma

multiple interactions

beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein

NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

decreases phosphorylation

beta Carotene results in decreased phosphorylation of RELA protein

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ribonuclease P 14 subunit

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA

NCBI chr14:14,377,927...14,389,460
Ensembl chr14:14,377,939...14,389,406

G

ribonucleotide reductase M1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA

NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978

G

retinoid X receptor alpha

multiple interactions

beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

scavenger receptor class B, member 1

increases transport

SCARB1 protein results in increased transport of beta Carotene

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

sine oculis-related homeobox 6

increases expression

beta Carotene results in increased expression of SIX6 mRNA

NCBI chr12:72,986,656...72,991,673
Ensembl chr12:72,986,666...72,991,673

G

solute carrier family 2 (facilitated glucose transporter), member 4

decreases expression

beta Carotene results in decreased expression of SLC2A4 mRNA

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

superoxide dismutase 1, soluble

decreases expression

beta Carotene results in decreased expression of SOD1 mRNA

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]

PMID:18779489 PMID:23859036

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

serine palmitoyltransferase, long chain base subunit 2

affects expression

beta Carotene affects the expression of SPTLC2 mRNA

NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129

G

sterol regulatory element binding transcription factor 1

increases expression

beta Carotene results in increased expression of SREBF1 mRNA

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

transcription factor CP2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA

NCBI chr15:100,395,083...100,449,896
Ensembl chr15:100,395,893...100,449,889

G

transglutaminase 2, C polypeptide

increases expression

beta Carotene results in increased expression of TGM2 mRNA

NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356

G

transglutaminase 4 (prostate)

increases expression

beta Carotene results in increased expression of TGM4 mRNA

NCBI chr 9:122,863,806...122,896,623
Ensembl chr 9:122,863,791...122,896,626

G

THO complex 7

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA

NCBI chr14:8,507,911...8,520,751
Ensembl chr14:8,507,911...8,520,751

G

transmembrane protein 209

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA

NCBI chr 6:30,480,806...30,509,786
Ensembl chr 6:30,479,052...30,509,782

G

tumor necrosis factor

multiple interactions

beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]
beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:19135038 PMID:21447443

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 9

increases expression

beta Carotene results in increased expression of TNFRSF9 mRNA

NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559

G

tumor necrosis factor (ligand) superfamily, member 10

increases expression

beta Carotene results in increased expression of TNFSF10 mRNA

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

tetratricopeptide repeat domain 21B

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA

NCBI chr 2:66,014,131...66,087,144
Ensembl chr 2:66,014,671...66,086,961

G

twinfilin actin binding protein 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA

NCBI chr15:94,475,829...94,487,727
Ensembl chr15:94,475,832...94,487,770

G

thioredoxin domain containing 9

increases expression

beta Carotene results in increased expression of TXNDC9 mRNA

NCBI chr 1:38,022,385...38,036,324
Ensembl chr 1:38,024,270...38,036,974

G

thymidine phosphorylase

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA

NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242

G

vascular endothelial growth factor A

decreases expression

beta Carotene results in decreased expression of VEGFA mRNA

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

X-ray repair complementing defective repair in Chinese hamster cells 3

increases expression

beta Carotene results in increased expression of XRCC3 mRNA

NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307

G

YTH domain containing 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA

NCBI chr18:44,961,521...45,022,782
Ensembl chr18:44,960,813...45,022,791

G

zinc finger, DHHC domain containing 3

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA

NCBI chr 9:122,895,224...122,942,269
Ensembl chr 9:122,895,225...122,942,270

bixin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear factor, erythroid derived 2, like 2

decreases ubiquitination

bixin results in decreased ubiquitination of NFE2L2 protein

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

canthaxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Canthaxanthin results in increased expression of CYP1A1 mRNA

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Canthaxanthin results in increased expression of CYP1A2 mRNA

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

capsanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein, alpha 1

multiple interactions

capsanthin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

mitogen-activated protein kinase 1

multiple interactions

capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

carotenoid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

beta-carotene oxygenase 2

decreases metabolic processing
multiple interactions

BCO2 gene mutant form results in decreased metabolism of Carotenoids
[[BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids] which results in increased expression of SOD2 protein; [BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids; BCO2 protein results in increased oxidation of and results in increased cleavage of Carotenoids

NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481

G

catalase

increases activity

Carotenoids results in increased activity of CAT protein

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects response to substance

CYP1A2 protein polymorphism affects the susceptibility to Carotenoids

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

N-acetyl transferase 1

affects response to substance

NAT1 protein polymorphism affects the susceptibility to Carotenoids

NCBI chr 8:67,943,620...67,945,183
Ensembl chr 8:67,933,573...67,944,756

G

N-acetyltransferase 2 (arylamine N-acetyltransferase)

affects response to substance

NAT2 protein polymorphism affects the susceptibility to Carotenoids

NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236

G

peroxisome proliferator activated receptor gamma

decreases expression

Carotenoids results in decreased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

retinoic acid receptor, gamma

increases expression

Carotenoids results in increased expression of RARG mRNA

NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952

G

superoxide dismutase 2, mitochondrial

multiple interactions
increases expression

[[BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids] which results in increased expression of SOD2 protein
Carotenoids results in increased expression of SOD2 protein

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

crocin-1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 5, tartrate resistant

multiple interactions

crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007

G

actin alpha 2, smooth muscle, aorta

multiple interactions

crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

thymoma viral proto-oncogene 2

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]

NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251

G

autophagy related 5

multiple interactions

crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

BMP and activin membrane-bound inhibitor

multiple interactions

crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA]

NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404

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BCL2-associated X protein

multiple interactions
increases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein]
crocin results in increased expression of BAX mRNA
crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein]

PMID:23523949 PMID:26231423 PMID:27353299 PMID:32886819 PMID:32920515 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

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B cell leukemia/lymphoma 2

multiple interactions
decreases expression

[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA; crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein]
crocin results in decreased expression of BCL2 mRNA
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]

PMID:26231423 PMID:31911963 PMID:32886819 PMID:32920515

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

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brain derived neurotrophic factor

increases expression

crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

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beclin 1, autophagy related

multiple interactions

crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]; crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of BECN1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

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baculoviral IAP repeat-containing 5

decreases expression

crocin results in decreased expression of BIRC5 mRNA

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

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caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]
crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
crocin results in increased expression of CASP3 mRNA

PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

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caspase 8

increases activity

crocin results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

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caspase 9

multiple interactions
increases activity

crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
crocin results in increased activity of CASP9 protein

PMID:27353299 PMID:32886819 PMID:35274200

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

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catalase

multiple interactions
increases activity
decreases activity

crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
crocin results in increased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein]
crocin results in decreased activity of CAT protein

PMID:25899501 PMID:26231423 PMID:26584762 PMID:29409856 PMID:32886819 More...

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

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cyclin D1

decreases expression

crocin results in decreased expression of CCND1 mRNA

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

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creatine kinase, muscle

multiple interactions

crocin inhibits the reaction [Diazinon results in increased activity of CKM protein]

NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766

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collagen, type II, alpha 1

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]

NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576

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cAMP responsive element binding protein 1

multiple interactions

crocin results in increased expression of and results in increased phosphorylation of CREB1 protein

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

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cytochrome c, somatic

multiple interactions

crocin inhibits the reaction [Diazinon affects the localization of CYCS protein]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

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cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]
crocin results in decreased activity of CYP2E1 protein

PMID:25899501 PMID:32633567

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

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forkhead box P2

increases expression

crocin results in increased expression of FOXP2 protein

NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976

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glyoxalase 1

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]

NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845

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glutamic pyruvic transaminase, soluble

multiple interactions

crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein]
crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein]

PMID:26231423 PMID:32259551 PMID:32633567

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

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heme oxygenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

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heat shock protein 1-like

multiple interactions

crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261

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interleukin 10

multiple interactions

crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

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interleukin 1 beta

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]

PMID:24709313 PMID:26807765

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

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interleukin 6

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
crocin results in decreased expression of IL6 mRNA

PMID:25637687 PMID:25899501 PMID:29409856 PMID:32633567 PMID:32886819 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

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insulin I

multiple interactions

crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

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Janus kinase 2

multiple interactions

crocin affects the expression of and affects the phosphorylation of JAK2 protein

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

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kelch-like ECH-associated protein 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein]

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

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low density lipoprotein receptor

multiple interactions

crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]

NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215

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microtubule-associated protein 1 light chain 3 beta

multiple interactions

[Quercetin co-treated with crocin] inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]]

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

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mitogen-activated protein kinase 1

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein]
crocin results in decreased phosphorylation of MAPK1 protein

PMID:24132704 PMID:28689058 PMID:32886819

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

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mitogen-activated protein kinase 3

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein]
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]
crocin results in decreased phosphorylation of MAPK3 protein

PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

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microRNA 122

multiple interactions
decreases expression

crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA]
crocin results in decreased expression of MIR122

PMID:28689058 PMID:36988377

NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997

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microRNA 29b-1

multiple interactions
increases expression

Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]

NCBI chr 6:31,039,958...31,040,028
Ensembl chr 6:31,039,958...31,040,028

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microRNA 34a

multiple interactions

MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]

NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012

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myeloperoxidase

multiple interactions

crocin inhibits the reaction [Ethanol results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

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myelocytomatosis oncogene

decreases expression

crocin results in decreased expression of MYC mRNA

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

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v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

multiple interactions
decreases response to substance
decreases expression

crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
MYCN results in decreased susceptibility to crocin
crocin results in decreased expression of MYCN protein

NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915

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myeloid differentiation primary response gene 88

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein]

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

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nuclear factor, erythroid derived 2, like 2

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]

PMID:32259551 PMID:32920515

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

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NAD(P)H dehydrogenase, quinone 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

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osteopetrosis associated transmembrane protein 1

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]

NCBI chr10:42,554,912...42,578,458
Ensembl chr10:42,459,818...42,578,455

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poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases cleavage

MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

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peroxisome proliferator activated receptor gamma

multiple interactions

crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

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protein kinase, AMP-activated, beta 1 non-catalytic subunit

multiple interactions

crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]

NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567

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prostaglandin-endoperoxide synthase 2

decreases expression

crocin results in decreased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

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protein tyrosine phosphatase, non-receptor type 4

multiple interactions
increases expression

MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]

NCBI chr 1:119,580,197...119,765,281
Ensembl chr 1:119,580,197...119,765,343

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v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein]

PMID:29409856 PMID:32920515

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

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SMAD family member 2

multiple interactions
decreases expression

Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]

NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034

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synuclein, alpha

multiple interactions

crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

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sprouty RTK signaling antagonist 2

increases expression

crocin results in increased expression of SPRY2 protein

NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253

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sequestosome 1

multiple interactions

crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

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signal transducer and activator of transcription 3

multiple interactions

crocin affects the expression of and affects the phosphorylation of STAT3 protein

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

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transforming growth factor, beta 1

multiple interactions

crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]

PMID:29409856 PMID:32259551 PMID:32633567 PMID:33021114

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

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transforming growth factor, beta receptor I

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]

NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931

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toll-like receptor 4

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein]

PMID:29409856 PMID:32259551

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

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tumor necrosis factor

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]
crocin results in decreased expression of TNF mRNA

PMID:25637687 PMID:25899501 PMID:26807765 PMID:32633567 PMID:32886819 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

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tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

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troponin T2, cardiac

multiple interactions

crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]

NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998

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TNF receptor-associated factor 6

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]

NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014

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transformation related protein 53

multiple interactions

crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein]

PMID:26231423 PMID:31911963

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

VGF nerve growth factor inducible

increases expression

crocin results in increased expression of VGF protein

NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205

fucoxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-Coenzyme A oxidase 1, palmitoyl

increases expression

fucoxanthin results in increased expression of ACOX1 mRNA

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

actin alpha 1, skeletal muscle

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ACTA1 mRNA]

NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490

G

adenylate cyclase 7

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased methylation of ADCY7 gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of ADCY7 mRNA]

NCBI chr 8:88,998,818...89,056,593
Ensembl chr 8:88,999,031...89,056,590

G

adenylate kinase 8

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of AK8 mRNA]

NCBI chr 2:28,588,287...28,703,177
Ensembl chr 2:28,590,176...28,703,177

G

thymoma viral proto-oncogene 1

multiple interactions
decreases expression

fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of AKT1 protein]
fucoxanthin results in decreased expression of AKT1 mRNA

PMID:26418808 PMID:35266250

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

activated leukocyte cell adhesion molecule

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ALCAM mRNA]

NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437

G

ankyrin repeat domain 61

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ANKRD61 mRNA]

NCBI chr 5:143,827,455...143,831,885
Ensembl chr 5:143,827,559...143,834,503

G

Rho, GDP dissociation inhibitor beta

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ARHGDIB mRNA]

NCBI chr 6:136,900,653...136,918,895
Ensembl chr 6:136,900,653...136,918,897

G

armadillo repeat containing, X-linked 6

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ARMCX6 mRNA]

NCBI chr X:133,649,204...133,657,236
Ensembl chr X:133,649,210...133,652,166

G

autophagy related 10

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ATG10 mRNA]

NCBI chr13:91,083,467...91,372,189
Ensembl chr13:91,083,475...91,372,087

G

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ATP2A1 mRNA]

NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280

G

BMP and activin membrane-bound inhibitor

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of BAMBI mRNA]

NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404

G

butyrylcholinesterase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of BCHE mRNA]

NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748

G

B cell leukemia/lymphoma 2

decreases expression

fucoxanthin results in decreased expression of BCL2 mRNA; fucoxanthin results in decreased expression of BCL2 protein

PMID:35266250 PMID:38444163

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]; BCL2L1 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]

PMID:20594983 PMID:38444163

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

baculoviral IAP repeat-containing 5

decreases expression

fucoxanthin results in decreased expression of BIRC5 protein

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

bone morphogenetic protein 8b

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of BMP8B mRNA]

NCBI chr 4:122,998,101...123,019,887
Ensembl chr 4:122,998,958...123,025,892

G

caspase 3

increases cleavage
multiple interactions

fucoxanthin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein]

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

castor zinc finger 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CASZ1 mRNA]

NCBI chr 4:148,888,823...149,039,350
Ensembl chr 4:148,888,886...149,039,346

G

catalase

multiple interactions

fucoxanthin inhibits the reaction [Carrageenan results in decreased activity of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

coiled-coil domain containing 116

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CCDC116 mRNA]

NCBI chr16:16,956,928...16,965,459
Ensembl chr16:16,956,928...16,965,093

G

C-C motif chemokine receptor 10

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CCR10 mRNA]

NCBI chr11:101,063,824...101,066,269
Ensembl chr11:101,063,823...101,066,269

G

CD1d1 antigen

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CD1D1 mRNA]

NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748

G

cadherin, EGF LAG seven-pass G-type receptor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CELSR1 mRNA]

NCBI chr15:85,782,959...85,918,424
Ensembl chr15:85,783,130...85,918,404

G

cell migration inducing protein, hyaluronan binding

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CEMIP mRNA]

NCBI chr 7:83,582,065...83,735,893
Ensembl chr 7:83,582,065...83,735,710

G

complement factor properdin

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CFP mRNA]

NCBI chr X:20,791,693...20,797,794
Ensembl chr X:20,791,693...20,797,794

G

calponin 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CNN1 mRNA]

NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926

G

collagen, type VII, alpha 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of COL7A1 mRNA]

NCBI chr 9:108,782,654...108,813,943
Ensembl chr 9:108,782,654...108,813,943

G

carboxypeptidase Q

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CPQ mRNA]

NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698

G

cytokine receptor-like factor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CRLF1 mRNA]

NCBI chr 8:70,945,798...70,956,728
Ensembl chr 8:70,945,808...70,956,731

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CYP2E1 mRNA]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

diazepam binding inhibitor-like 5

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of DBIL5 mRNA]

NCBI chr11:76,108,439...76,109,491
Ensembl chr11:76,108,434...76,109,492

G

dispatched RND transporter family member 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of DISP2 mRNA]

NCBI chr 2:118,610,183...118,625,656
Ensembl chr 2:118,610,200...118,641,774

G

dematin actin binding protein

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of DMTN mRNA]

NCBI chr14:70,839,624...70,873,488
Ensembl chr14:70,838,703...70,873,418

G

dopamine receptor D3

increases activity

fucoxanthin results in increased activity of DRD3 protein

NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295

G

dopamine receptor D4

increases activity

fucoxanthin results in increased activity of DRD4 protein

NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377

G

dual specificity phosphatase 13B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of DUSP13B mRNA]

NCBI chr14:21,783,463...21,792,947
Ensembl chr14:21,783,462...21,792,947

G

endosome-lysosome associated apoptosis and autophagy regulator 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ELAPOR1 mRNA]

NCBI chr 3:108,362,995...108,444,064
Ensembl chr 3:108,363,010...108,443,852

G

epithelial splicing regulatory protein 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ESRP1 mRNA]

NCBI chr 4:11,331,933...11,386,783
Ensembl chr 4:11,331,933...11,386,783

G

family with sequence similarity 78, member B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM78B mRNA]

NCBI chr 1:166,827,456...166,918,871
Ensembl chr 1:166,828,986...166,918,871

G

family with sequence similarity 83, member C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of FAM83C mRNA]

NCBI chr 2:155,671,103...155,676,772
Ensembl chr 2:155,669,468...155,676,774

G

family with sequence similarity 98, member C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM98C mRNA]

NCBI chr 7:28,851,935...28,855,653
Ensembl chr 7:28,851,935...28,855,659

G

fructose bisphosphatase 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FBP2 mRNA]

NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236

G

FCH domain only 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FCHO1 mRNA]

NCBI chr 8:72,161,031...72,181,980
Ensembl chr 8:72,161,031...72,178,360

G

fibroblast growth factor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FGF1 mRNA]

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

fibrinogen-like protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of FGL2 mRNA]

NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372

G

filaggrin

decreases expression

fucoxanthin results in decreased expression of FLG mRNA

NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993

G

Friend virus susceptibility 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of FV1 mRNA]

NCBI chr 4:147,953,436...147,954,815
Ensembl chr 4:147,953,436...147,954,815

G

glucose-6-phosphate dehydrogenase 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of G6PD2 mRNA]

NCBI chr 5:61,966,186...61,967,820
Ensembl chr 5:61,966,159...61,968,506

G

golgi associated kinase 1B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GASK1B mRNA]

NCBI chr 3:79,791,795...79,853,585
Ensembl chr 3:79,791,840...79,853,587

G

guanylate-binding protein 8

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GBP8 mRNA]

NCBI chr 5:105,160,379...105,201,475
Ensembl chr 5:105,162,016...105,287,406

G

gap junction protein, alpha 1

increases expression

fucoxanthin results in increased expression of GJA1 mRNA; fucoxanthin results in increased expression of GJA1 protein

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

gap junction protein, beta 1

increases expression

fucoxanthin results in increased expression of GJB1 mRNA; fucoxanthin results in increased expression of GJB1 protein

NCBI chr X:100,419,982...100,429,235
Ensembl chr X:100,419,984...100,429,235

G

guanine nucleotide binding protein (G protein), gamma 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of GNG2 mRNA]

NCBI chr14:19,922,626...20,027,893
Ensembl chr14:19,922,627...20,027,695

G

glycoprotein m6b

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GPM6B mRNA]

NCBI chr X:165,021,911...165,172,028
Ensembl chr X:165,021,907...165,171,984

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GRIN1 mRNA]

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

gulonolactone (L-) oxidase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GULO mRNA]

NCBI chr14:66,224,235...66,246,703
Ensembl chr14:66,224,235...66,246,656

G

glycophorin C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of GYPC mRNA]

NCBI chr18:32,661,373...32,693,087
Ensembl chr18:32,661,375...32,693,087

G

hedgehog acyltransferase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of HHAT mRNA]

NCBI chr 1:192,195,133...192,453,546
Ensembl chr 1:192,179,019...192,453,531

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

decreases activity

fucoxanthin results in decreased activity of HMGCR protein

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

heme oxygenase 1

increases expression

fucoxanthin results in increased expression of HMOX1 protein

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hormonally upregulated Neu-associated kinase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of HUNK mRNA]

NCBI chr16:90,182,550...90,296,443
Ensembl chr16:90,182,901...90,296,441

G

islet cell autoantigen 1-like

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICA1L mRNA]

NCBI chr 1:60,024,955...60,082,646
Ensembl chr 1:60,021,649...60,082,343

G

intercellular adhesion molecule 5, telencephalin

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICAM5 mRNA]

NCBI chr 9:20,943,372...20,950,331
Ensembl chr 9:20,943,369...20,950,332

G

interferon-induced protein 44

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of IFI44 mRNA]

NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597

G

interferon inducible GTPase 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of IIGP1 mRNA]

NCBI chr18:60,506,688...60,525,706
Ensembl chr18:60,509,099...60,525,706

G

interleukin 1 beta

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]

PMID:22735499 PMID:35616142

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 23 receptor

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL23R mRNA]

NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839

G

interleukin 24

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL24 mRNA]

NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191

G

interleukin 6

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]
fucoxanthin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:22735499 PMID:35616142 PMID:38444163

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

inositol 1,4,5-triphosphate receptor associated 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of IRAG1 mRNA]

NCBI chr 7:110,467,464...110,582,116
Ensembl chr 7:110,467,473...110,581,668

G

interferon regulatory factor 7

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of IRF7 mRNA]

NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394

G

Janus kinase 2

decreases phosphorylation

fucoxanthin results in decreased phosphorylation of JAK2 protein

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

kidney androgen regulated protein

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of KAP mRNA]

NCBI chr 6:133,826,818...133,830,630
Ensembl chr 6:133,826,814...133,830,725

G

Kv channel-interacting protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of KCNIP2 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of KCNIP2 gene]

NCBI chr19:45,780,785...45,804,948
Ensembl chr19:45,780,278...45,804,500

G

lysophosphatidylcholine acyltransferase 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of LPCAT1 mRNA]

NCBI chr13:73,615,332...73,664,539
Ensembl chr13:73,615,316...73,664,541

G

leucine rich repeat containing 61

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of LRRC61 mRNA]

NCBI chr 6:48,531,732...48,547,656
Ensembl chr 6:48,531,730...48,547,656

G

leukotriene C4 synthase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of LTC4S mRNA]

NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443

G

lymphocyte antigen 96

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of LY96 mRNA]

NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835

G

male germ cell-associated kinase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAK mRNA]

NCBI chr13:41,178,483...41,233,182
Ensembl chr13:41,178,484...41,233,182

G

MAM domain containing 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAMDC2 mRNA]

NCBI chr19:23,279,973...23,425,855
Ensembl chr19:23,279,973...23,425,806

G

monoamine oxidase A

decreases activity

fucoxanthin results in decreased activity of MAOA protein

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

monoamine oxidase B

decreases activity

fucoxanthin results in decreased activity of MAOB protein

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

mitogen-activated protein kinase kinase kinase 13

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAP3K13 mRNA]

NCBI chr16:21,643,923...21,752,189
Ensembl chr16:21,613,096...21,752,189

G

mitogen-activated protein kinase 1

multiple interactions

fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK1 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:26418808 PMID:35616142

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK3 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

PMID:26418808 PMID:35616142

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

myeloid cell leukemia sequence 1

decreases expression

fucoxanthin results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

major facilitator superfamily domain containing 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of MFSD3 mRNA]

NCBI chr15:76,585,742...76,588,439
Ensembl chr15:76,585,665...76,588,439

G

mechanistic target of rapamycin kinase

decreases expression

fucoxanthin results in decreased expression of MTOR mRNA

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

myosin VIIB

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MYO7B mRNA]

NCBI chr18:32,092,287...32,169,984
Ensembl chr18:32,092,287...32,170,014

G

naked cuticle 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA]

NCBI chr13:73,966,653...73,995,750
Ensembl chr13:73,966,653...73,995,750

G

nitric oxide synthase 2, inducible

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]

PMID:22735499 PMID:26418808

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nuclear receptor binding protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of NRBP2 mRNA]

NCBI chr15:75,957,364...75,963,539
Ensembl chr15:75,957,367...75,963,476

G

neurotrimin

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of NTM mRNA]

NCBI chr 9:28,906,045...29,874,565
Ensembl chr 9:28,906,046...29,874,437

G

neurexophilin and PC-esterase domain family, member 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of NXPE4 mRNA]

NCBI chr 9:48,073,302...48,311,325
Ensembl chr 9:48,073,321...48,311,325

G

2'-5' oligoadenylate synthetase 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of OAS3 mRNA]

NCBI chr 5:120,891,163...120,915,755
Ensembl chr 5:120,891,163...120,915,726

G

olfactory receptor family 1 subfamily O member 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of OR1O4 mRNA]

NCBI chr17:37,590,392...37,591,309
Ensembl chr17:37,589,934...37,594,351

G

protein kinase C and casein kinase substrate in neurons 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PACSIN1 mRNA]

NCBI chr17:27,874,565...27,930,092
Ensembl chr17:27,874,483...27,930,456

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage
multiple interactions

fucoxanthin results in increased cleavage of PARP1 protein
BCL2L1 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

protocadherin 17

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDH17 mRNA]

NCBI chr14:84,680,626...84,775,005
Ensembl chr14:84,681,003...84,776,442

G

protocadherin gamma subfamily B, 6

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDHGB6 mRNA]

NCBI chr18:37,875,147...37,974,926
Ensembl chr18:37,875,147...37,974,926

G

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased methylation of PIP5K1B gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of PIP5K1B mRNA]

NCBI chr19:24,272,158...24,533,236
Ensembl chr19:24,272,158...24,533,236

G

PITPNM family member 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of PITPNM3 mRNA]

NCBI chr11:71,938,354...72,026,715
Ensembl chr11:71,938,354...72,026,604

G

peroxisome proliferator activated receptor alpha

increases expression

fucoxanthin results in increased expression of PPARA mRNA

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activated receptor gamma

decreases expression

fucoxanthin results in decreased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

presenilin 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of PSEN2 mRNA]

NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003

G

prostaglandin-endoperoxide synthase 2

multiple interactions

fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]

PMID:22735499 PMID:26418808

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

prostaglandin-endoperoxide synthase 2, opposite strand

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA]

NCBI chr 1:149,950,624...149,975,625
Ensembl chr 1:149,909,888...149,975,714

G

Rab40B, member RAS oncogene family

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of RAB40B mRNA]

NCBI chr11:121,246,951...121,279,080
Ensembl chr11:121,246,951...121,279,077

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

resistin

decreases expression

fucoxanthin results in decreased expression of RETN protein

NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110

G

ras homolog family member A

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased activity of RHOA protein]

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

G

receptor transporter protein 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of RTP4 mRNA]

NCBI chr16:23,338,976...23,432,972
Ensembl chr16:23,339,041...23,432,972

G

SHC (Src homology 2 domain containing) family, member 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA]

NCBI chr 2:125,469,359...125,566,085
Ensembl chr 2:125,469,367...125,566,068

G

solute carrier family 16 (monocarboxylic acid transporters), member 5

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC16A5 mRNA]

NCBI chr11:115,353,231...115,365,224
Ensembl chr11:115,353,300...115,365,224

G

solute carrier family 18 (vesicular monoamine), member 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC18A2 mRNA]

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 6 (neurotransmitter transporter), member 18

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of SLC6A18 mRNA]

NCBI chr13:73,809,869...73,826,142
Ensembl chr13:73,809,871...73,826,142

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

fucoxanthin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]
fucoxanthin results in decreased phosphorylation of STAT3 protein

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

striatin interacting protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of STRIP2 mRNA]

NCBI chr 6:29,916,975...29,959,680
Ensembl chr 6:29,917,011...29,959,680

G

synapsin I

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYN1 mRNA]

NCBI chr X:20,726,750...20,787,157
Ensembl chr X:20,726,750...20,787,243

G

synaptopodin 2-like

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYNPO2L mRNA]

NCBI chr14:20,709,013...20,718,422
Ensembl chr14:20,709,014...20,718,422

G

transforming growth factor beta 1 induced transcript 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TGFB1I1 mRNA]

NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871

G

thrombospondin, type I, domain containing 7A

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA]

NCBI chr 6:12,311,607...12,749,252
Ensembl chr 6:12,311,609...12,749,409

G

transmembrane protein with EGF-like and two follistatin-like domains 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEFF1 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of TMEFF1 gene]

NCBI chr 4:48,585,064...48,663,136
Ensembl chr 4:48,585,174...48,663,131

G

transmembrane protein 229B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEM229B mRNA]

NCBI chr12:79,008,569...79,054,333
Ensembl chr12:79,008,569...79,054,401

G

tumor necrosis factor

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]

PMID:22735499 PMID:35616142

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor (ligand) superfamily, member 13

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TNFSF13 mRNA]

NCBI chr11:69,573,403...69,576,380
Ensembl chr11:69,573,672...69,576,610

G

tetratricopeptide repeat domain 21A

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TTC21A mRNA]

NCBI chr 9:119,766,656...119,798,496
Ensembl chr 9:119,766,672...119,796,859

G

wingless-type MMTV integration site family, member 7B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of WNT7B mRNA]

NCBI chr15:85,419,638...85,466,022
Ensembl chr15:85,419,638...85,466,674

G

zinc finger protein 521

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA]

NCBI chr18:13,820,070...14,105,812
Ensembl chr18:13,820,070...14,105,844

G

zinc finger protein 566

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ZFP566 mRNA]

NCBI chr 7:29,776,762...29,789,935
Ensembl chr 7:29,776,762...29,789,952

G

ZXD family zinc finger C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZXDA mRNA]

NCBI chr 6:90,346,460...90,380,472
Ensembl chr 6:90,346,474...90,380,472

lutein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alsin Rho guanine nucleotide exchange factor

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA
Lutein results in decreased expression of ALS2 mRNA

NCBI chr 1:59,201,915...59,276,390
Ensembl chr 1:59,202,085...59,276,390

G

APC, WNT signaling pathway regulator

multiple interactions

[Cisplatin co-treated with Lutein] results in increased expression of APC mRNA

NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605

G

aquarius

decreases expression
multiple interactions

Lutein results in decreased expression of AQR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA

NCBI chr 2:113,931,642...114,005,788
Ensembl chr 2:113,931,651...114,017,505

G

ataxia telangiectasia and Rad3 related

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA
Lutein results in decreased expression of ATR mRNA

NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834

G

BCL2-associated X protein

increases expression

Lutein results in increased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

Lutein results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

increases expression

Lutein results in increased expression of BCL2L1 protein

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

beta-carotene oxygenase 2

increases metabolic processing
affects metabolic processing
multiple interactions

BCO2 protein results in increased metabolism of Lutein
BCO2 protein affects the metabolism of Lutein
[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite

NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481

G

catalase

multiple interactions

Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cyclin D1

decreases expression

Lutein results in decreased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

copper chaperone for superoxide dismutase

increases expression

Lutein results in increased expression of CCS mRNA

NCBI chr19:4,875,394...4,889,326
Ensembl chr19:4,875,394...4,889,360

G

complement factor D

decreases expression
decreases secretion

Lutein results in decreased expression of CFD mRNA
Lutein results in decreased secretion of CFD protein

NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489

G

creatine kinase, brain

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein]

NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772

G

cathepsin B

increases expression
multiple interactions

Lutein results in increased expression of CTSB mRNA
Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cytochrome b-245, alpha polypeptide

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA
Lutein results in decreased expression of CYBA mRNA

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

desmin

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein]

NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223

G

excision repair cross-complementing rodent repair deficiency, complementation group 2

decreases expression
multiple interactions

Lutein results in decreased expression of ERCC2 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA

NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619

G

excision repair cross-complementing rodent repair deficiency, complementation group 6

decreases expression

Lutein results in decreased expression of ERCC6 mRNA

NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947

G

flavin containing monooxygenase 2

decreases expression

Lutein results in decreased expression of FMO2 mRNA

NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295

G

growth factor receptor bound protein 2-associated protein 1

decreases expression
multiple interactions

Lutein results in decreased expression of GAB1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA

NCBI chr 8:81,491,060...81,607,151
Ensembl chr 8:81,491,063...81,607,148

G

glutathione peroxidase 1

multiple interactions
increases expression

Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]

PMID:22040935 PMID:24865317

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 2

multiple interactions

[Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA

NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273

G

glutathione peroxidase 3

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutathione reductase

increases expression
multiple interactions

Lutein results in increased expression of GSR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase kappa 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA

NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381

G

hemoglobin, theta 1A

increases expression

Lutein results in increased expression of HBQ1A mRNA

NCBI chr11:32,250,069...32,250,873
Ensembl chr11:32,250,069...32,250,873

G

heme oxygenase 1

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein

PMID:25815309 PMID:26187899

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

isocitrate dehydrogenase 1 (NADP+), soluble

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA
Lutein results in decreased expression of IDH1 mRNA

NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659

G

intraflagellar transport 172

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA
Lutein results in decreased expression of IFT172 mRNA

NCBI chr 5:31,410,623...31,448,458
Ensembl chr 5:31,410,621...31,448,460

G

insulin I

decreases expression
multiple interactions

Lutein results in decreased expression of INS1 protein
[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein; [Lutein co-treated with Ascorbic Acid] results in decreased expression of INS1 protein

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

kinesin family member 9

multiple interactions
increases expression

Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA]
Lutein results in increased expression of KIF9 mRNA

NCBI chr 9:110,306,062...110,354,242
Ensembl chr 9:110,306,026...110,354,247

G

myoglobin

increases expression

Lutein results in increased expression of MB mRNA

NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870

G

microsomal glutathione S-transferase 1

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA]

PMID:25815309 PMID:26187899

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

myocardial infarction associated transcript (non-protein coding)

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT]

NCBI chr 5:112,361,094...112,376,814
Ensembl chr 5:112,361,094...112,377,261

G

microRNA 200a

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA]

NCBI chr 4:156,139,353...156,139,442
Ensembl chr 4:156,139,353...156,139,442

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression

Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein
Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]
Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein

PMID:25815309 PMID:26187899 PMID:34435724

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

neuroglobin

increases expression

Lutein results in increased expression of NGB mRNA

NCBI chr12:87,144,305...87,149,313
Ensembl chr12:87,144,305...87,149,313

G

NADPH oxidase 4

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA
Lutein results in decreased expression of NOX4 mRNA

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

NADPH oxidase organizer 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA

NCBI chr17:24,915,208...24,919,504
Ensembl chr17:24,915,208...24,919,503

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases expression

[Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]
Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein

PMID:24865317 PMID:25815309 PMID:26187899

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nudix hydrolase 15

decreases expression
multiple interactions

Lutein results in decreased expression of NUDT15 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA

NCBI chr14:73,756,320...73,785,682
Ensembl chr14:73,756,317...73,785,682

G

nucleoredoxin

increases expression
multiple interactions

Lutein results in increased expression of NXN mRNA
Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]

NCBI chr11:76,148,052...76,289,967
Ensembl chr11:76,148,024...76,289,966

G

Parkinson disease (autosomal recessive, early onset) 7

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA

NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894

G

protein phosphatase 1, regulatory subunit 15B

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA
Lutein results in decreased expression of PPP1R15B mRNA

NCBI chr 1:133,058,904...133,067,538
Ensembl chr 1:133,058,881...133,067,521

G

peroxiredoxin 4

increases expression

Lutein results in increased expression of PRDX4 mRNA

NCBI chr X:154,106,914...154,125,268
Ensembl chr X:154,106,914...154,123,750

G

peroxiredoxin 5

decreases expression

Lutein results in decreased expression of PRDX5 mRNA

NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474

G

peroxiredoxin 6

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA
Lutein results in decreased expression of PRDX6 mRNA

NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789

G

peroxiredoxin 6B

decreases expression
multiple interactions

Lutein results in decreased expression of PRDX6B mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of PRDX6B mRNA

NCBI chr 2:80,122,814...80,125,702
Ensembl chr 2:80,122,816...80,125,700

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

stearoyl-Coenzyme A desaturase 1

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SCD1 mRNA
Lutein results in decreased expression of SCD1 mRNA

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

superoxide dismutase 1, soluble

multiple interactions
increases expression

Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA]
Lutein results in increased expression of SOD1 mRNA

PMID:22040935 PMID:24865317

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]
Lutein results in decreased expression of SOD2 mRNA

PMID:22040935 PMID:24865317

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA
Lutein results in decreased expression of SOD3 mRNA

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

sulfiredoxin 1 homolog (S. cerevisiae)

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA
Lutein results in decreased expression of SRXN1 mRNA

NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296

G

troponin T2, cardiac

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein]

NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998

G

thioredoxin 1

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of TXN protein]

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin interacting protein

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased expression of TXNIP protein]

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thioredoxin reductase 1

decreases expression
multiple interactions

Lutein results in decreased expression of TXNRD1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

uncoupling protein 3 (mitochondrial, proton carrier)

increases expression

Lutein results in increased expression of UCP3 mRNA

NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639

G

vimentin

increases expression

Lutein results in increased expression of VIM mRNA

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

xin actin-binding repeat containing 1

increases expression

Lutein results in increased expression of XIRP1 mRNA

NCBI chr 9:119,842,821...119,852,660
Ensembl chr 9:119,842,821...119,852,664

lycopene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

Lycopene inhibits the reaction [bisphenol A results in decreased activity of ACE protein]

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

acetylcholinesterase

multiple interactions

Lycopene inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of ACHE protein]

PMID:22192907 PMID:26900785

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

activin receptor IIB

decreases expression

Lycopene results in decreased expression of SCGB2A2 mRNA

NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061

G

adducin 1

decreases expression

lycopene results in decreased expression of ADD1 mRNA

NCBI chr 5:34,731,008...34,789,652
Ensembl chr 5:34,731,008...34,789,652

G

advanced glycosylation end product-specific receptor

multiple interactions

lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

aryl-hydrocarbon receptor

decreases expression
multiple interactions

lycopene results in decreased expression of AHR mRNA
[Lycopene co-treated with Atrazine] results in increased expression of AHR mRNA; Lycopene inhibits the reaction [Atrazine results in increased expression of AHR protein]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AHR mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of and results in increased localization of AHR protein]

PMID:16886892 PMID:36216167 PMID:36403809

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

allograft inflammatory factor 1

multiple interactions

lycopene inhibits the reaction [Galactose results in increased expression of AIF1 protein]

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

thymoma viral proto-oncogene 1

decreases phosphorylation

lycopene results in decreased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

aminolevulinate, delta-, dehydratase

multiple interactions

lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]
lycopene inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]

PMID:17516994 PMID:25682699

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

aquaporin 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of AQP1 mRNA]

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

aquaporin 11

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP11 mRNA]

NCBI chr 7:97,375,586...97,387,454
Ensembl chr 7:97,373,213...97,387,496

G

aquaporin 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP2 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of AQP2 protein]

NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428

G

aquaporin 4

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP4 mRNA]

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

aquaporin 6

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP6 mRNA]

NCBI chr15:99,495,891...99,503,359
Ensembl chr15:99,499,281...99,503,358

G

aquaporin 7

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP7 mRNA]

NCBI chr 4:41,033,074...41,048,237
Ensembl chr 4:41,033,074...41,048,139

G

androgen receptor

decreases expression

lycopene results in decreased expression of AR mRNA

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
increases expression

Lycopene inhibits the reaction [Atrazine results in increased expression of ARNT mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ARNT mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ARNT protein]
Lycopene results in increased expression of ARNT mRNA

PMID:36216167 PMID:36403809

NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551

G

activating transcription factor 6

multiple interactions

Lycopene inhibits the reaction [Oxaliplatin results in increased expression of ATF6 mRNA]

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

autophagy related 10

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG10 mRNA]

NCBI chr13:91,083,467...91,372,189
Ensembl chr13:91,083,475...91,372,087

G

autophagy related 13

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG13 mRNA]

NCBI chr 2:91,504,957...91,540,947
Ensembl chr 2:91,504,963...91,540,921

G

autophagy related 14

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG14 mRNA]

NCBI chr14:47,778,350...47,805,891
Ensembl chr14:47,778,350...47,808,106

G

autophagy related 16 like 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG16L1 mRNA]

NCBI chr 1:87,683,730...87,720,150
Ensembl chr 1:87,683,592...87,720,150

G

autophagy related 16 like 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG16L2 mRNA]

NCBI chr 7:100,935,521...100,951,474
Ensembl chr 7:100,912,241...100,951,458

G

autophagy related 2B

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG2B mRNA]

NCBI chr12:105,579,798...105,651,554
Ensembl chr12:105,582,395...105,651,470

G

autophagy related 3

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG3 mRNA]

NCBI chr16:44,979,192...45,008,901
Ensembl chr16:44,979,148...45,008,901

G

autophagy related 4A, cysteine peptidase

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG4A mRNA]

NCBI chr X:139,854,594...139,947,190
Ensembl chr X:139,857,656...139,947,266

G

autophagy related 4B, cysteine peptidase

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG4B mRNA]

NCBI chr 1:93,682,627...93,717,328
Ensembl chr 1:93,679,222...93,718,332

G

autophagy related 4C, cysteine peptidase

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG4C mRNA]

NCBI chr 4:99,077,181...99,185,495
Ensembl chr 4:99,082,171...99,148,024

G

autophagy related 5

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG5 mRNA]
[Glucose co-treated with Lycopene] results in increased expression of ATG5 mRNA

PMID:30360616 PMID:38444079

NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287

G

autophagy related 7

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG7 mRNA]

NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575

G

autophagy related 9A

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG9A mRNA]

NCBI chr 1:75,157,509...75,168,654
Ensembl chr 1:75,157,504...75,168,840

G

autophagy related 9B

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG9B mRNA]

NCBI chr 5:24,589,179...24,597,141
Ensembl chr 5:24,589,179...24,597,141

G

ATPase, Na+/K+ transporting, alpha 1 polypeptide

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP1A1 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP1A1 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000

G

ATPase, Na+/K+ transporting, alpha 2 polypeptide

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A2 mRNA]

PMID:27112537 PMID:33960999

NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631

G

ATPase, Na+/K+ transporting, alpha 3 polypeptide

multiple interactions

lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A3 mRNA]

NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383

G

ATPase, Na+/K+ transporting, alpha 4 polypeptide

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP1A4 mRNA]

PMID:26476475 PMID:27112537

NCBI chr 1:172,051,075...172,085,991
Ensembl chr 1:172,051,080...172,085,981

G

ATPase, Na+/K+ transporting, beta 1 polypeptide

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B1 mRNA]

PMID:27112537 PMID:33960999

NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924

G

ATPase, Na+/K+ transporting, beta 2 polypeptide

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP1B2 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B2 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768

G

ATPase, Na+/K+ transporting, beta 3 polypeptide

multiple interactions

lycopene inhibits the reaction [Atrazine affects the expression of ATP1B3 mRNA]

NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495

G

ATPase Na+/K+ transporting, beta 4 polypeptide

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B4 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP1B4 mRNA]

PMID:26476475 PMID:33960999

NCBI chr X:37,404,999...37,425,661
Ensembl chr X:37,405,061...37,425,646

G

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2A1 mRNA]

NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280

G

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2A2 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2A2 mRNA]

PMID:27112537 PMID:33960999

NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288

G

ATPase, Ca++ transporting, ubiquitous

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2A3 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2A3 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870

G

ATPase, Ca++ transporting, plasma membrane 1

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2B1 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2B1 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005

G

ATPase, Ca++ transporting, plasma membrane 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B2 mRNA]

PMID:26476475 PMID:27112537

NCBI chr 6:113,720,803...114,019,574
Ensembl chr 6:113,720,792...114,019,574

G

ATPase, Ca++ transporting, plasma membrane 3

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B3 mRNA]

PMID:26476475 PMID:27112537

NCBI chr X:72,546,356...72,632,267
Ensembl chr X:72,546,692...72,614,611

G

ATPase, Ca++ transporting, plasma membrane 4

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2B4 mRNA]

PMID:26476475 PMID:27112537

NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779

G

ATPase, Ca++-sequestering

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2C1 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr 9:105,288,561...105,398,456
Ensembl chr 9:105,280,738...105,404,518

G

ATPase, Ca++ transporting, type 2C, member 2

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2C2 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C2 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr 8:120,426,748...120,484,457
Ensembl chr 8:120,426,748...120,484,456

G

BTB and CNC homology 1, basic leucine zipper transcription factor 1

increases expression

lycopene results in increased expression of BACH1 mRNA

NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234

G

BCL2-antagonist/killer 1

multiple interactions

Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAK1 protein]

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

Brca1 associated protein 1

increases expression

lycopene results in increased expression of BAP1 mRNA

NCBI chr14:30,973,358...30,981,887
Ensembl chr14:30,973,407...30,981,901

G

BCL2-associated X protein

multiple interactions

Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Lycopene inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Sodium Glutamate results in increased expression of BAX mRNA]
Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]

PMID:26900785 PMID:27871895 PMID:31568845 PMID:32153214 PMID:36583613

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

butyrylcholinesterase

multiple interactions

Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of BCHE protein]

NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748

G

B cell leukemia/lymphoma 2

multiple interactions
increases expression

[Glucose co-treated with Lycopene] results in increased expression of BCL2 mRNA; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]; Lycopene inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Sodium Glutamate results in decreased expression of BCL2 mRNA]
Lycopene results in increased expression of BCL2 mRNA
lycopene inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]

PMID:16030430 PMID:26900785 PMID:27871895 PMID:31568845 PMID:32153214 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

beta-carotene oxygenase 1

multiple interactions

BCO1 affects the reaction [lycopene results in decreased abundance of Testosterone]

NCBI chr 8:117,822,590...117,860,459
Ensembl chr 8:117,822,593...117,860,459

G

brain derived neurotrophic factor

multiple interactions

Lycopene inhibits the reaction [Galactose results in decreased expression of BDNF mRNA]; Lycopene inhibits the reaction [Galactose results in decreased expression of BDNF protein]
Lycopene inhibits the reaction [bisphenol A results in decreased expression of BDNF protein]; Lycopene inhibits the reaction [Oxaliplatin results in decreased expression of BDNF protein]

PMID:28974442 PMID:32153214 PMID:32544411

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

beclin 1, autophagy related

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of BECN1 mRNA]
[Glucose co-treated with Lycopene] results in increased expression of BECN1 mRNA

PMID:30360616 PMID:38444079

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112