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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amrinone
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Accession:CHEBI:2686 term browser browse the term
Definition:A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Synonyms:exact_synonym: 5-amino[3,4'-bipyridin]-6(1H)-one
 related_synonym: 3-amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone;   3-amino-5-(4-pyridinyl)-2(1H)-pyridinone;   3-amino-5-pyridin-4-yl-1H-pyridin-2-one;   5-amino-1,6-dihydro-6-oxo-[3,4'-bipyridine];   Formula=C10H9N3O;   InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14);   InChIKey=RNLQIBCLLYYYFJ-UHFFFAOYSA-N;   SMILES=C1=CN=CC=C1C2=CNC(=O)C(=C2)N;   WIN 40680;   amrinona;   amrinonum;   inamrinone
 alt_id: CHEBI:95269
 xref: CAS:60719-84-8;   DrugBank:DB01427;   Drug_Central:201;   HMDB:HMDB0015496;   KEGG:D00231;   LINCS:LSM-6600
 xref_mesh: MESH:D000676
 xref: PMID:10513074;   PMID:10835763;   PMID:10919416;   PMID:10969688;   PMID:10972600;   PMID:12076859;   PMID:12111179;   PMID:12354747;   PMID:14754535;   PMID:15064331;   PMID:15892406;   PMID:15972057;   PMID:16154150;   PMID:16236146;   PMID:17582263;   PMID:18468627;   PMID:23112975;   PMID:23184630;   PMID:23908328;   PMID:28166217;   PMID:29764757;   PMID:31194440;   PMID:3764113;   PMID:3916118;   PMID:39684;   PMID:7379253;   Wikipedia:Amrinone


show annotations for term's descendants           Sort by:
amrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Amrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:9004165 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Amrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:9004165 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pharmaceutical 19548
          drug 19548
            cardiovascular drug 8654
              amrinone 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organonitrogen heterocyclic compound 18176
                                    bipyridines 4319
                                      amrinone 2
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