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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:styrenes
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Accession:CHEBI:26799 term browser browse the term
Synonyms:xref_mesh: MESH:D013343


show annotations for term's descendants           Sort by:
styrenes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 affects binding ISO Styrenes analog binds to ESR1 protein CTD PMID:11485868 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of AKT1 protein] CTD PMID:38521250 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of BAX protein CTD PMID:38521250 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of BCL2 protein CTD PMID:38521250 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein]		 CTD PMID:38521250 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP9 protein CTD PMID:38521250 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CCNB1 protein CTD PMID:38521250 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDC25C protein CTD PMID:38521250 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDK1 protein CTD PMID:38521250 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1A protein CTD PMID:38521250 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1B protein CTD PMID:38521250 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CYCS protein CTD PMID:38521250 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]		 CTD PMID:31029725 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein		 CTD PMID:31029725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31029725 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA] CTD PMID:31029725 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein] CTD PMID:38521250 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:31029725 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:31029725 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]		 CTD PMID:31029725 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein]		 CTD PMID:38521250 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]		 CTD PMID:31029725 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein] CTD PMID:31029725 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]		 CTD PMID:31029725 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]		 CTD PMID:31029725 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of PARP1 protein] CTD PMID:38521250 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of PIK3R1 protein] CTD PMID:38521250 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of SQSTM1 protein CTD PMID:38521250 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA] CTD PMID:31029725 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
2',4,4',6'-tetrahydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of naringenin chalcone CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of naringenin chalcone CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
2'-hydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions		 ISO 2'-hydroxychalcone results in decreased activity of CYP1A1 protein
2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]		 CTD PMID:15596260 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
multiple interactions		 ISO 2'-hydroxychalcone results in decreased activity of CYP1B1 protein
2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]		 CTD PMID:15596260 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 2'-hydroxychalcone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
4-hydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP 4-hydroxychalcone binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ar androgen receptor affects binding EXP 4-hydroxychalcone binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
affects chemical synthesis		 ISO
EXP		 4-hydroxychalcone results in decreased activity of CYP1A1 protein
CYP1A1 protein affects the chemical synthesis of 4-hydroxychalcone		 CTD PMID:15596260 PMID:15863696 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects chemical synthesis EXP CYP1A2 protein affects the chemical synthesis of 4-hydroxychalcone CTD PMID:15863696 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO 4-hydroxychalcone results in decreased activity of CYP1B1 protein CTD PMID:15596260 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects chemical synthesis EXP CYP2C6 protein affects the chemical synthesis of 4-hydroxychalcone CTD PMID:15863696 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO 4-hydroxychalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
4-hydroxystyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions
increases abundance		 ISO [CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of 4-vinylphenol
CYP2F2 protein results in increased abundance of 4-vinylphenol		 CTD PMID:24320693 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
4-methoxycinnamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP 4-methoxycinnamic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CAT] CTD PMID:22326950 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP 4-methoxycinnamic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of GSR] CTD PMID:22326950 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
chalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Chalcone binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ar androgen receptor affects binding EXP Chalcone binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Chalcone results in decreased activity of CA1 protein CTD PMID:30431690 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Chalcone results in decreased activity of CA2 protein CTD PMID:30431690 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO Chalcone results in increased cleavage of CASP3 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]		 CTD PMID:20620131 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions		 ISO Chalcone results in increased cleavage of CASP8 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]		 CTD PMID:20620131 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO Chalcone results in increased cleavage of CASP9 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]		 CTD PMID:20620131 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation EXP CYP1A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation EXP CYP1A2 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation EXP CYP2C6 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chalcone analog results in increased expression of GCLM mRNA; Chalcone analog results in increased expression of GCLM protein CTD PMID:31299238 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hat1 histone acetyltransferase 1 decreases activity ISO Chalcone analog results in decreased activity of HAT1 protein CTD PMID:22155221 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22155221 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22155221 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155221 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22155221 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:22155221 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
multiple interactions		 ISO MYC protein affects the susceptibility to Chalcone
Chalcone promotes the reaction [MYC protein results in increased abundance of Reactive Oxygen Species]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]		 CTD PMID:20620131 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Chalcone analog results in decreased ubiquitination of and results in decreased degradation of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione] CTD PMID:31299238 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22155221 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155221 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Chalcone analog results in increased expression of NQO1 mRNA; Chalcone analog results in increased expression of NQO1 protein CTD PMID:31299238 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Chalcone results in increased cleavage of PARP1 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]		 CTD PMID:20620131 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Chalcone analog results in increased expression of PPARG mRNA CTD PMID:28528971 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of Chalcone CTD PMID:11524419 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased phosphorylation of RELA protein] which results in increased acetylation of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22155221 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Chalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22155221 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Ethyl cinnamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ethyl cinnamate binds to and results in increased activity of ESR1 protein CTD PMID:16079615 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ethyl cinnamate binds to and results in increased activity of ESR2 protein CTD PMID:16079615 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
flavokawain B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of ADGRE1 protein] CTD PMID:38583725 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO flavokawain B results in decreased phosphorylation of AKT1 protein
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]		 CTD PMID:30025493 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein] CTD PMID:30025493 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
affects response to substance		 ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 affects response to substance
multiple interactions		 ISO ATG7 protein affects the susceptibility to flavokawain B
[ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]		 CTD PMID:30025493 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased cleavage of BAX protein]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of BAX protein] CTD PMID:38583725 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of BCL2 protein] CTD PMID:38583725 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein CTD PMID:30025493 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of CCL2 mRNA] CTD PMID:38583725 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein CTD PMID:30025493 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO flavokawain B results in increased phosphorylation of EIF2AK3 protein CTD PMID:30025493 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO flavokawain B results in increased phosphorylation of EIF2S1 protein CTD PMID:30025493 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
increases expression		 ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein
flavokawain B results in increased expression of GLB1 protein		 CTD PMID:30025493 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO flavokawain B results in increased phosphorylation of H2AX protein CTD PMID:30025493 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO flavokawain B results in increased expression of HSPA5 protein CTD PMID:30025493 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] CTD PMID:38583725 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 mRNA] CTD PMID:38583725 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of IL1B mRNA] CTD PMID:38583725 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il33 interleukin 33 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL33 mRNA] CTD PMID:38583725 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of IL6 mRNA]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased secretion of IL6 protein] CTD PMID:38583725 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAP3K7 protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased phosphorylation of MAP3K7 protein] CTD PMID:38583725 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein CTD PMID:30025493 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein] CTD PMID:30025493 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate promotes the reaction [TLR2 protein binds to MYD88 protein]] CTD PMID:38583725 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of NFKBIA protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in decreased expression of NFKBIA protein] CTD PMID:38583725 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein CTD PMID:30025493 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased phosphorylation of RELA protein] CTD PMID:38583725 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions		 ISO flavokawain B results in decreased phosphorylation of RPS6KB1 protein
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:30025493 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO flavokawain B results in increased expression of SQSTM1 protein CTD PMID:30025493 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
affects binding		 ISO flavokawain B inhibits the reaction [Dextran Sulfate promotes the reaction [TLR2 protein binds to MYD88 protein]]
flavokawain B binds to TLR2 protein		 CTD PMID:38583725 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TNF mRNA]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased secretion of TNF protein] CTD PMID:38583725 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression		 ISO ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30025493 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] CTD PMID:38583725 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
isobavachalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO Enzymes and Coenzymes inhibits the reaction [isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO isobavachalcone results in decreased activity of CES1 protein CTD PMID:26560012 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions		 EXP isobavachalcone results in decreased activity of CYP2E1 protein
isobavachalcone inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]		 CTD PMID:31870919 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 EXP isobavachalcone inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]
isobavachalcone results in decreased activity of CYP3A4 protein		 CTD PMID:31870919 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO isobavachalcone results in increased cleavage of PARP1 protein CTD PMID:30890322 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
isoliquiritigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP isoliquiritigenin binds to AFP protein CTD PMID:23013281 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein] CTD PMID:25110319 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
decreases phosphorylation		 ISO AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]
isoliquiritigenin results in decreased phosphorylation of AKT1 protein		 CTD PMID:23747687 PMID:25094029 PMID:27117918 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Arg1 arginase 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein] CTD PMID:25026504 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein CTD PMID:11055382 PMID:27702603 PMID:38311047 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases phosphorylation ISO isoliquiritigenin results in decreased phosphorylation of BCL2 protein CTD PMID:23747687 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
decreases phosphorylation		 ISO isoliquiritigenin results in decreased expression of BCL2L1 protein
isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein		 CTD PMID:11055382 PMID:15729620 PMID:23747687 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO isoliquiritigenin results in decreased expression of BIRC2 protein CTD PMID:15729620 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO isoliquiritigenin results in decreased expression of BIRC3 protein CTD PMID:15729620 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage		 ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein
isoliquiritigenin results in increased expression of CASP3 mRNA
isoliquiritigenin results in increased activity of CASP3 protein		 CTD PMID:15729620 PMID:16158945 PMID:23747687 PMID:25094029 PMID:38311047 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO isoliquiritigenin results in increased activity of CASP8 protein CTD PMID:16158945 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
increases cleavage		 ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein
isoliquiritigenin results in increased expression of CASP9 mRNA
isoliquiritigenin results in increased activity of CASP9 protein		 CTD PMID:16158945 PMID:23747687 PMID:25094029 PMID:38311047 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
increases expression		 EXP
ISO		 isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
isoliquiritigenin results in increased expression of CAT mRNA
isoliquiritigenin inhibits the reaction [Paroxetine results in decreased activity of CAT protein]		 CTD PMID:25450236 PMID:36740106 PMID:38311047 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cckar cholecystokinin A receptor multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] CTD PMID:27702603 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO isoliquiritigenin results in decreased expression of CCND2 mRNA CTD PMID:27702603 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO isoliquiritigenin results in decreased expression of CCNE2 mRNA CTD PMID:27702603 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein CTD PMID:27702603 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO isoliquiritigenin results in decreased expression of CDKN1B mRNA CTD PMID:27702603 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO isoliquiritigenin results in decreased expression of CDKN1C mRNA CTD PMID:27702603 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein] CTD PMID:27117918 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein] CTD PMID:18295200 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ctsb cathepsin B decreases expression ISO isoliquiritigenin results in decreased expression of CTSB protein CTD PMID:38311047 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA] CTD PMID:25026504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO isoliquiritigenin results in decreased expression of CYP17A1 mRNA CTD PMID:27773742 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO isoliquiritigenin results in decreased expression of CYP19A1 mRNA CTD PMID:27773742 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:25110319 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
isoliquiritigenin results in decreased activity of CYP1A2 protein		 CTD PMID:25110319 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
isoliquiritigenin results in increased expression of CYP1B1 mRNA		 CTD PMID:25110319 PMID:26134484 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO isoliquiritigenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] CTD PMID:25450236 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO isoliquiritigenin results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] CTD PMID:37561086 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of ERN1 mRNA] CTD PMID:37561086 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein] CTD PMID:27117918 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO isoliquiritigenin results in decreased expression of FOXO3 mRNA CTD PMID:38311047 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 increases expression ISO isoliquiritigenin results in increased expression of GADD45GIP1 mRNA CTD PMID:27702603 NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] CTD PMID:19834288 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO isoliquiritigenin inhibits the reaction [Paroxetine results in increased activity of GPT protein] CTD PMID:36740106 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO isoliquiritigenin results in decreased expression of GPX1 mRNA CTD PMID:38311047 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP isoliquiritigenin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:37561086 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] CTD PMID:37561086 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoliquiritigenin results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO isoliquiritigenin results in decreased expression of HSD17B1 mRNA CTD PMID:27773742 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions EXP [isoliquiritigenin co-treated with Cisplatin] results in increased expression of HSP90B1 protein CTD PMID:37561086 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP [Cisplatin co-treated with isoliquiritigenin] results in increased expression of HSPA5 mRNA
isoliquiritigenin results in increased expression of HSPA5 mRNA		 CTD PMID:37561086 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]		 CTD PMID:23942037 PMID:25026504 PMID:26134484 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein] CTD PMID:25026504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein] CTD PMID:25026504 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:18295200 PMID:25026504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] CTD PMID:27117918 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Insr insulin receptor multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] CTD PMID:27117918 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression		 ISO TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein] CTD PMID:24369695 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression ISO isoliquiritigenin results in decreased expression of MAP1LC3B protein CTD PMID:38311047 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:18295200 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:18295200 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression ISO isoliquiritigenin results in decreased expression of MELK mRNA; isoliquiritigenin results in decreased expression of MELK protein CTD PMID:36893906 NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937 		JBrowse link
G Mfn2 mitofusin 2 increases expression EXP isoliquiritigenin results in increased expression of MFN2 protein CTD PMID:37561086 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein CTD PMID:27702603 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]
isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein		 CTD PMID:25094029 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]
isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein		 CTD PMID:25094029 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein] CTD PMID:25026504 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO isoliquiritigenin results in decreased expression of NFE2L2 mRNA CTD PMID:38311047 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein] CTD PMID:18295200 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
decreases phosphorylation		 ISO isoliquiritigenin results in increased expression of NFKBIA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
isoliquiritigenin results in decreased phosphorylation of NFKBIA protein		 CTD PMID:15729620 PMID:18295200 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein] CTD PMID:18295200 PMID:19834288 PMID:25026504 PMID:26134484 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isoliquiritigenin results in increased expression of NQO1 protein CTD PMID:26473469 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression		 ISO isoliquiritigenin results in increased activity of NR1I2 protein
isoliquiritigenin results in increased expression of NR1I2 mRNA		 CTD PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO isoliquiritigenin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein]		 CTD PMID:23747687 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases phosphorylation ISO isoliquiritigenin results in decreased phosphorylation of PDK1 protein CTD PMID:25094029 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO isoliquiritigenin results in decreased expression of PLA2G5 mRNA CTD PMID:23747687 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO isoliquiritigenin results in increased expression of POU5F1 mRNA CTD PMID:38311047 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein] CTD PMID:27117918 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein CTD PMID:25094029 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO isoliquiritigenin results in decreased expression of PTGS1 mRNA CTD PMID:25094029 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO
EXP		 isoliquiritigenin results in decreased expression of PTGS2 mRNA
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]		 CTD PMID:18295200 PMID:23747687 PMID:25026504 PMID:25450236 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein] CTD PMID:27117918 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity		 ISO isoliquiritigenin affects the localization of RELA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]
isoliquiritigenin results in decreased activity of RELA protein		 CTD PMID:15729620 PMID:18295200 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO isoliquiritigenin results in increased expression of SIRT1 mRNA CTD PMID:38311047 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity		 ISO isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
isoliquiritigenin results in decreased activity of SLC2A1 protein		 CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein] CTD PMID:27117918 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:19834288 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 multiple interactions
decreases activity		 EXP [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance
increases expression		 ISO SOD2 protein affects the susceptibility to isoliquiritigenin
isoliquiritigenin results in increased expression of SOD2 mRNA		 CTD PMID:23526725 PMID:38311047 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO isoliquiritigenin results in increased expression of STAR mRNA CTD PMID:27773742 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein] CTD PMID:25026504 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein] CTD PMID:25026504 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]		 CTD PMID:18295200 PMID:25026504 PMID:25450236 PMID:26134484 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO isoliquiritigenin results in increased expression of TRP53 mRNA CTD PMID:27702603 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of XBP1 mRNA] CTD PMID:37561086 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Lucidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO lucidone results in increased expression of HMOX1 protein
[lucidone co-treated with 2,2'-azobis(2-amidinopropane)] results in increased expression of HMOX1 protein; lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; lucidone inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]		 CTD PMID:22484158 PMID:23712098 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects response to substance		 ISO [lucidone co-treated with 2,2'-azobis(2-amidinopropane)] affects the localization of and results in increased activity of NFE2L2 protein; [lucidone co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; lucidone affects the localization of and results in increased activity of NFE2L2 protein; lucidone promotes the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of NFE2L2 protein]
NFE2L2 protein affects the susceptibility to lucidone		 CTD PMID:22484158 PMID:23712098 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of NFKBIA protein] CTD PMID:23712098 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of PTGS2 protein] CTD PMID:23712098 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) affects the localization of RELA protein] CTD PMID:23712098 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lucidone inhibits the reaction [Ethanol results in increased expression of TNF] CTD PMID:22484158 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
okanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO okanin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO okanin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
phlorizin chalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO isosalipurposide results in increased expression of HMOX1 protein CTD PMID:26028482 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO MAPK1 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein] CTD PMID:26028482 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO MAPK3 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein] CTD PMID:26028482 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO isosalipurposide affects the localization of NFE2L2 protein
MAPK1 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein]; MAPK3 protein affects the reaction [isosalipurposide affects the localization of NFE2L2 protein]		 CTD PMID:26028482 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
sappanchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO sappanchalcone affects the localization of AIFM1 protein CTD PMID:32590072 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sappanchalcone results in increased expression of BAX protein CTD PMID:21963806 PMID:32590072 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sappanchalcone results in decreased expression of BCL2 protein CTD PMID:21963806 PMID:32590072 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO sappanchalcone results in increased activity of CASP3 protein
sappanchalcone results in increased cleavage of CASP3 protein		 CTD PMID:21963806 PMID:32590072 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO sappanchalcone results in increased cleavage of CASP7 protein CTD PMID:32590072 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO sappanchalcone results in increased cleavage of CASP8 protein CTD PMID:32590072 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO sappanchalcone results in increased activity of CASP9 protein
sappanchalcone results in increased cleavage of CASP9 protein		 CTD PMID:21963806 PMID:32590072 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO sappanchalcone results in increased phosphorylation of MAPK8 protein CTD PMID:21963806 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sappanchalcone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:21963806 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO sappanchalcone results in increased cleavage of PARP1 protein CTD PMID:32590072 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sappanchalcone affects the localization of RELA protein CTD PMID:21963806 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO sappanchalcone results in increased expression of TP53 protein
sappanchalcone results in increased expression of and results in increased phosphorylation of TP53 protein		 CTD PMID:21963806 PMID:32590072 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
styrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity ISO Styrene results in decreased activity of ALAD protein CTD PMID:16140629 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alb albumin increases secretion
multiple interactions		 ISO Styrene results in increased secretion of ALB protein
Styrene promotes the reaction [styrene oxide binds to ALB protein]		 CTD PMID:10511253 PMID:15895243 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [[Volatile Organic Compounds results in increased abundance of Styrene] which results in increased abundance of mandelic acid] which results in increased expression of ALPL protein CTD PMID:34668566 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Aqp9 aquaporin 9 increases expression EXP Styrene results in increased expression of AQP9 mRNA CTD PMID:17654243 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Atf3 activating transcription factor 3 affects expression ISO Styrene affects the expression of ATF3 mRNA CTD PMID:28951217 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 increases expression EXP Styrene results in increased expression of ATP6V0D2 mRNA CTD PMID:17654243 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Styrene results in decreased expression of BAX protein CTD PMID:15212811 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Styrene results in increased expression of BCL2 protein CTD PMID:15212811 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Styrene results in increased expression of BCL2L1 protein CTD PMID:16705669 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Styrene results in decreased expression of BCL6 mRNA CTD PMID:28951217 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Styrene results in increased expression of BHLHE40 mRNA CTD PMID:28951217 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 decreases expression ISO Styrene results in decreased expression of BMAL1 mRNA CTD PMID:28951217 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO Styrene results in decreased expression of BPTF mRNA CTD PMID:28951217 NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769 		JBrowse link
G Casp8 caspase 8 increases activity EXP Styrene results in increased activity of CASP8 protein CTD PMID:17420221 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity EXP Styrene results in increased activity of CASP9 protein CTD PMID:17420221 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity ISO Styrene results in decreased activity of CAT protein CTD PMID:16169704 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
affects expression		 ISO Styrene results in increased expression of CCL2 mRNA; Styrene results in increased expression of CCL2 protein
Styrene affects the expression of CCL2 mRNA		 CTD PMID:15212811 PMID:17993253 PMID:36912746 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Styrene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:36416909 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 decreases expression ISO Styrene results in decreased expression of CCR1 mRNA; Styrene results in decreased expression of CCR1 protein CTD PMID:15212811 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Clock clock circadian regulator decreases expression ISO Styrene results in decreased expression of CLOCK mRNA CTD PMID:28951217 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Clu clusterin decreases expression EXP Styrene results in decreased expression of CLU mRNA CTD PMID:17654243 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression ISO Styrene affects the expression of CXCL2 mRNA CTD PMID:36912746 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO Styrene affects the expression of CXCL1 mRNA CTD PMID:36912746 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects response to substance ISO CYP1A1 gene polymorphism affects the susceptibility to Styrene CTD PMID:12604177 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]
Styrene results in increased expression of CYP1A2 mRNA; Styrene results in increased expression of CYP1A2 protein		 CTD PMID:16418063 PMID:18202523 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression		 EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]
Styrene results in increased expression of CYP2B1 mRNA; Styrene results in increased expression of CYP2B1 protein		 CTD PMID:16418063 PMID:18202523 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
increases expression		 EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]
Styrene results in increased expression of CYP2B2 mRNA; Styrene results in increased expression of CYP2B2 protein		 CTD PMID:16418063 PMID:18202523 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Styrene results in decreased expression of CYP2C11 mRNA CTD PMID:16418063 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases metabolic processing
increases oxidation
increases metabolic processing
increases expression
affects response to substance
multiple interactions
increases response to substance
affects metabolic processing
affects oxidation		 ISO
EXP		 CYP2E1 gene polymorphism results in decreased metabolism of Styrene
CYP2E1 protein results in increased oxidation of Styrene
CYP2E1 protein results in increased metabolism of Styrene
Styrene results in increased expression of CYP2E1 mRNA
CYP2E1 gene polymorphism affects the susceptibility to Styrene
Styrene results in increased expression of CYP2E1 mRNA; Styrene results in increased expression of CYP2E1 protein
gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; [Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene
CYP2E1 protein results in increased susceptibility to Styrene
CYP2E1 protein affects the metabolism of Styrene
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene analog; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]; S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; Smoke inhibits the reaction [CYP2E1 protein affects the metabolism of Styrene]
CYP2E1 protein affects the oxidation of Styrene
CYP2E1 gene polymorphism results in increased susceptibility to Styrene; CYP2E1 protein results in increased susceptibility to Styrene
CYP2E1 gene polymorphism affects the metabolism of Styrene; CYP2E1 protein affects the metabolism of Styrene		 CTD PMID:1664256 PMID:11535253 PMID:12464798 PMID:12604177 PMID:12746132 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases response to substance
decreases response to substance
increases metabolic processing
multiple interactions		 ISO CYP2F2 protein results in increased susceptibility to Styrene
CYP2F2 gene mutant form results in decreased susceptibility to Styrene
CYP2F2 protein results in increased metabolism of Styrene
[CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of 4-vinylphenol; [CYP2F2 protein results in increased metabolism of Styrene] which results in increased abundance of styrene glycol		 CTD PMID:22386858 PMID:24320693 PMID:28962520 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 EXP gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein] CTD PMID:18202523 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Styrene results in increased expression of DBP mRNA CTD PMID:28951217 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Styrene results in increased expression of E2F8 mRNA CTD PMID:28951217 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098 		JBrowse link
G Egr1 early growth response 1 increases expression
affects expression		 ISO Styrene results in increased expression of EGR1 mRNA
Styrene affects the expression of EGR1 mRNA		 CTD PMID:24086524 PMID:28951217 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
decreases response to substance
affects response to substance		 EXP
ISO		 Styrene results in increased expression of EPHX1 mRNA
EPHX1 protein results in decreased susceptibility to Styrene
EPHX1 gene polymorphism affects the susceptibility to Styrene		 CTD PMID:14751678 PMID:16418063 PMID:22386858 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erg ETS transcription factor ERG decreases expression ISO Styrene results in decreased expression of ERG mRNA CTD PMID:28951217 NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Styrene results in decreased expression of FN1 mRNA CTD PMID:33064461 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
affects expression		 ISO Styrene results in increased expression of FOS protein
Styrene affects the expression of FOS mRNA		 CTD PMID:15212811 PMID:28951217 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gck glucokinase increases expression EXP Styrene results in increased expression of GCK mRNA CTD PMID:28678435 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity ISO Styrene results in increased activity of GCLC protein CTD PMID:16971035 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Glud1 glutamate dehydrogenase 1 affects expression EXP Styrene affects the expression of GLUD1 mRNA CTD PMID:28678435 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance
multiple interactions
affects response to substance		 ISO GSTM1 gene polymorphism results in increased susceptibility to Styrene
GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]
GSTM1 gene polymorphism affects the susceptibility to Styrene		 CTD PMID:12016165 PMID:12464798 PMID:12717779 PMID:14751678 PMID:14979085 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance
increases response to substance
multiple interactions		 ISO GSTP1 exon polymorphism affects the susceptibility to Styrene; GSTP1 gene polymorphism affects the susceptibility to Styrene
GSTP1 gene polymorphism results in increased susceptibility to Styrene
GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene]		 CTD PMID:11535253 PMID:12397415 PMID:12604177 PMID:12893075 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases response to substance
affects response to substance		 ISO GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]
GSTT1 gene polymorphism affects the susceptibility to Styrene		 CTD PMID:12016165 PMID:12717779 PMID:14751678 PMID:16424821 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 increases expression ISO Styrene results in increased expression of HES6 mRNA CTD PMID:28951217 NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559 		JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member increases expression ISO Styrene results in increased expression of HLF mRNA CTD PMID:28951217 NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO Styrene affects the expression of HMOX1 mRNA CTD PMID:36912746 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions
increases mutagenesis		 ISO GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene] CTD PMID:11535253 PMID:12893075 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Styrene results in increased expression of HSPA1A protein CTD PMID:16705669 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Styrene results in increased expression of HSPA1L mRNA CTD PMID:24086524 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Styrene results in increased expression of IL1B mRNA
Styrene results in increased expression of and results in increased secretion of IL1B protein		 CTD PMID:24086524 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Styrene results in decreased expression of IL4 protein CTD PMID:16879906 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression
affects expression
multiple interactions		 ISO Styrene results in increased expression of IL6 mRNA
Styrene affects the expression of IL6 mRNA
Styrene results in increased expression of and results in increased secretion of IL6 protein		 CTD PMID:24086524 PMID:36912746 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO Styrene affects the expression of JUN protein CTD PMID:15212811 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klf7 KLF transcription factor 7 decreases expression ISO Styrene results in decreased expression of KLF7 mRNA CTD PMID:28951217 NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS gene polymorphism results in increased susceptibility to Styrene CTD PMID:12807761 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 decreases expression ISO Styrene results in decreased expression of LCP2 mRNA; Styrene results in decreased expression of LCP2 protein CTD PMID:15212811 NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559 		JBrowse link
G Mxd3 Max dimerization protein 3 increases expression ISO Styrene results in increased expression of MXD3 mRNA CTD PMID:28951217 NCBI chr17:9,301,430...9,305,156
Ensembl chr17:9,301,399...9,305,157 		JBrowse link
G Myb MYB proto-oncogene, transcription factor affects expression ISO Styrene affects the expression of MYB mRNA CTD PMID:28951217 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated affects expression
decreases expression		 ISO Styrene affects the expression of NFIL3 mRNA
Styrene results in decreased expression of NFIL3 mRNA		 CTD PMID:28951217 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression ISO Styrene results in decreased expression of NPAS2 mRNA CTD PMID:28951217 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects response to substance ISO NQO1 gene polymorphism affects the susceptibility to Styrene CTD PMID:14979085 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression ISO Styrene results in increased expression of NR1D1 mRNA CTD PMID:28951217 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO Styrene results in increased expression of NR1D2 mRNA CTD PMID:28951217 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 affects expression ISO Styrene affects the expression of NR4A1 mRNA CTD PMID:28951217 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Styrene results in decreased expression of NR4A2 mRNA CTD PMID:28951217 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Styrene results in decreased expression of NR4A3 mRNA CTD PMID:28951217 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase affects response to substance
increases expression		 ISO OGG1 protein polymorphism affects the susceptibility to Styrene
Styrene results in increased expression of OGG1 mRNA		 CTD PMID:19563869 PMID:21030303 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 increases expression EXP Styrene results in increased expression of PACSIN3 mRNA CTD PMID:17654243 NCBI chr 3:77,227,187...77,235,820
Ensembl chr 3:77,222,710...77,235,811 		JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Styrene results in increased expression of PER2 mRNA CTD PMID:28951217 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Per3 period circadian regulator 3 increases expression ISO Styrene results in increased expression of PER3 mRNA CTD PMID:28951217 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607 		JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
increases response to substance		 ISO POR protein results in increased metabolism of Styrene
POR protein results in increased susceptibility to Styrene		 CTD PMID:22386858 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP Styrene results in increased expression of PRDX1 mRNA CTD PMID:17654243 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Styrene results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Styrene results in increased expression of PTGS2 protein] CTD PMID:21801798 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone increases response to substance ISO PTHLH gene polymorphism results in increased susceptibility to Styrene CTD PMID:12807761 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO Styrene results in increased expression of RAF1 protein CTD PMID:15212811 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rora RAR-related orphan receptor A decreases expression ISO Styrene results in decreased expression of RORA mRNA CTD PMID:28951217 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression ISO Styrene results in decreased expression of SCGB1A1 mRNA CTD PMID:19428955 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Styrene results in decreased expression of SLC2A2 mRNA CTD PMID:28678435 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Sp5 Sp5 transcription factor increases expression ISO Styrene results in increased expression of SP5 mRNA CTD PMID:28951217 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733 		JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression ISO Styrene results in increased expression of TEF mRNA CTD PMID:28951217 NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783 		JBrowse link
G Tex101 testis expressed 101 increases expression EXP Styrene results in increased expression of TEX101 mRNA CTD PMID:17654243 NCBI chr 1:80,255,076...80,259,442
Ensembl chr 1:80,255,076...80,259,442 		JBrowse link
G Tfec transcription factor EC affects expression ISO Styrene affects the expression of TFEC mRNA CTD PMID:28951217 NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression ISO Styrene affects the expression of TGFB1 mRNA CTD PMID:36912746 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression ISO Styrene affects the expression of TGFB2 mRNA; Styrene affects the expression of TGFB2 protein CTD PMID:16705669 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 affects expression ISO Styrene affects the expression of TGFBR3 mRNA; Styrene affects the expression of TGFBR3 protein CTD PMID:16705669 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tgm2 transglutaminase 2 affects expression ISO Styrene affects the expression of TGM2 mRNA CTD PMID:36912746 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
increases expression		 ISO Styrene promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Styrene results in increased expression of and results in increased secretion of TNF protein
Styrene affects the expression of TNF mRNA
Styrene results in increased expression of TNF mRNA		 CTD PMID:24086524 PMID:36416909 PMID:36912746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression
multiple interactions		 ISO Styrene results in increased expression of TNFSF10 mRNA
Styrene results in increased expression of and results in increased secretion of TNFSF10 protein		 CTD PMID:24086524 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases response to substance ISO TRPA1 results in increased susceptibility to Styrene CTD PMID:20176620 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression ISO Styrene affects the expression of VCAM1 mRNA CTD PMID:36912746 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases response to substance
increases expression
affects response to substance		 ISO XRCC1 gene polymorphism results in increased susceptibility to Styrene
Styrene results in increased expression of XRCC1 mRNA
XRCC1 protein polymorphism affects the susceptibility to Styrene		 CTD PMID:15468052 PMID:15992842 PMID:21030303 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 affects response to substance ISO XRCC3 protein polymorphism affects the susceptibility to Styrene CTD PMID:15468052 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Styrene results in decreased expression of ZBTB20 mRNA CTD PMID:28951217 NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 decreases expression ISO Styrene results in decreased expression of ZKSCAN3 mRNA CTD PMID:28951217 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827 		JBrowse link
styrene oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding		 ISO styrene oxide promotes the reaction [styrene oxide binds to ALB protein]; Styrene promotes the reaction [styrene oxide binds to ALB protein] CTD PMID:10511253 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
increases expression		 ISO
EXP		 styrene oxide affects the expression of BAX mRNA
styrene oxide results in increased expression of BAX protein		 CTD PMID:11230554 PMID:12663515 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression		 ISO
EXP		 styrene oxide affects the expression of BCL2 mRNA
styrene oxide results in decreased expression of BCL2 protein		 CTD PMID:11230554 PMID:12663515 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO styrene oxide results in increased expression of BCL2L1 protein CTD PMID:16705669 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP		 styrene oxide results in increased activity of CASP3 protein CTD PMID:11929631 PMID:12663515 PMID:17662326 PMID:19666080 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO styrene oxide affects the expression of CDKN1A mRNA CTD PMID:11230554 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis ISO CYP2E1 results in increased chemical synthesis of styrene oxide; CYP2E1 results in increased chemical synthesis of styrene oxide analog CTD PMID:22366341 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases chemical synthesis ISO CYP2F2 protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions
affects hydrolysis		 EXP
ISO		 CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]
EPHX1 protein affects the metabolism of and results in decreased activity of styrene oxide		 CTD PMID:11076696 PMID:12051674 PMID:12694745 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO styrene oxide results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases response to substance
multiple interactions
affects metabolic processing		 ISO
EXP		 GSTM1 protein results in decreased susceptibility to styrene oxide
GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
GSTM1 protein affects the metabolism of styrene oxide		 CTD PMID:1638515 PMID:2604743 PMID:11424177 PMID:11599931 PMID:14698568 More... NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing
multiple interactions		 EXP GSTM2 protein affects the metabolism of styrene oxide
GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]		 CTD PMID:1638515 PMID:2604743 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 exon polymorphism affects the susceptibility to styrene oxide CTD PMID:12694745 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases response to substance
affects response to substance		 ISO GSTT1 gene polymorphism results in increased susceptibility to styrene oxide
GSTT1 protein affects the susceptibility to styrene oxide		 CTD PMID:12016165 PMID:15468052 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hbb hemoglobin subunit beta affects binding ISO styrene oxide binds to HBB protein CTD PMID:11948819 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO styrene oxide results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity		 ISO styrene oxide results in increased expression of HMOX1 protein
styrene oxide results in increased activity of HMOX1 protein		 CTD PMID:15582351 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO styrene oxide results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO styrene oxide results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO styrene oxide results in increased expression of MYC protein CTD PMID:16705669 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO styrene oxide results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO styrene oxide results in increased cleavage of PARP1 protein CTD PMID:11929631 PMID:17662326 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO styrene oxide results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Por cytochrome p450 oxidoreductase increases chemical synthesis ISO POR protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO styrene oxide results in decreased expression of RAC1 protein CTD PMID:17662326 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression ISO styrene oxide results in decreased expression of SCGB1A1 mRNA; styrene oxide results in decreased expression of SCGB1A1 protein CTD PMID:19428955 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO styrene oxide results in increased cleavage of SPTAN1 protein CTD PMID:11929631 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Syp synaptophysin decreases expression ISO styrene oxide results in decreased expression of SYP protein CTD PMID:17662326 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression ISO styrene oxide affects the expression of TGFB2 mRNA; styrene oxide affects the expression of TGFB2 protein CTD PMID:16705669 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 affects expression ISO styrene oxide affects the expression of TGFBR3 mRNA; styrene oxide affects the expression of TGFBR3 protein CTD PMID:16705669 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO styrene oxide results in increased expression of TNFRSF9 mRNA CTD PMID:22723965 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tp53 tumor protein p53 affects expression ISO styrene oxide affects the expression of TP53 mRNA CTD PMID:11230554 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects response to substance ISO XRCC1 protein polymorphism affects the susceptibility to styrene oxide CTD PMID:15468052 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
tetrachlorvinphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tetrachlorvinphos metabolite results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO Tetrachlorvinphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Tetrachlorvinphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Tetrachlorvinphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Tetrachlorvinphos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Tetrachlorvinphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Tetrachlorvinphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
trans-chalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Chalcone binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ar androgen receptor affects binding EXP Chalcone binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Chalcone results in decreased activity of CA1 protein CTD PMID:30431690 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Chalcone results in decreased activity of CA2 protein CTD PMID:30431690 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein] CTD PMID:20620131 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein] CTD PMID:20620131 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO Chalcone results in increased cleavage of CASP9 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]		 CTD PMID:20620131 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydroxylation EXP CYP1A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation EXP CYP1A2 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation EXP CYP2C6 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Chalcone CTD PMID:15863696 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chalcone analog results in increased expression of GCLM mRNA; Chalcone analog results in increased expression of GCLM protein CTD PMID:31299238 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hat1 histone acetyltransferase 1 decreases activity ISO Chalcone analog results in decreased activity of HAT1 protein CTD PMID:22155221 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22155221 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22155221 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155221 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22155221 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:22155221 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects response to substance		 ISO Chalcone promotes the reaction [MYC protein results in increased abundance of Reactive Oxygen Species]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]
MYC protein affects the susceptibility to Chalcone		 CTD PMID:20620131 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Chalcone analog results in decreased ubiquitination of and results in decreased degradation of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione] CTD PMID:31299238 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22155221 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155221 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Chalcone analog results in increased expression of NQO1 mRNA; Chalcone analog results in increased expression of NQO1 protein CTD PMID:31299238 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Chalcone results in increased cleavage of PARP1 protein
MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein]		 CTD PMID:20620131 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Chalcone analog results in increased expression of PPARG mRNA CTD PMID:28528971 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of Chalcone CTD PMID:11524419 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased phosphorylation of RELA protein] which results in increased acetylation of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22155221 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Chalcone binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22155221 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
trans-cinnamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:30144576 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:30144576 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein] CTD PMID:30144576 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 cinnamic acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]
cinnamic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]		 CTD PMID:22285266 PMID:23959918 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO cinnamic acid analog results in decreased activity of CYP17A1 protein CTD PMID:15072549 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO cinnamic acid analog results in decreased activity of CYP2C19 protein CTD PMID:15072549 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO cinnamic acid analog results in decreased activity of CYP2C8 protein CTD PMID:15072549
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO cinnamic acid analog results in decreased activity of CYP2D6 protein CTD PMID:15072549 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO cinnamic acid analog results in decreased activity of CYP2E1 protein CTD PMID:15072549 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO cinnamic acid analog results in decreased activity of CYP3A4 protein CTD PMID:15072549 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in increased expression of DNM1L protein] CTD PMID:30144576 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in increased expression of FIS1 protein] CTD PMID:30144576 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 affects binding ISO cinnamic acid binds to HCAR2 protein CTD PMID:21167710 NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO cinnamic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO cinnamic acid analog results in decreased activity of HSD3B2 protein CTD PMID:15072549 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Il6 interleukin 6 increases expression ISO cinnamic acid results in increased expression of IL6 mRNA CTD PMID:21870829 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in decreased expression of MFN2 protein] CTD PMID:30144576 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO cinnamic acid analog binds to and results in decreased activity of MMP2 protein CTD PMID:30048736 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO cinnamic acid analog binds to and results in decreased activity of MMP9 protein CTD PMID:30048736 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO cinnamic acid results in increased expression of NOS3 mRNA CTD PMID:15740983 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in increased expression of NPPA protein] CTD PMID:30144576 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO cinnamic acid binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO cinnamic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO cinnamic acid results in increased expression of PPARG mRNA CTD PMID:21870829 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO
EXP		 cinnamic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] CTD PMID:22981274 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO cinnamic acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO cinnamic acid results in increased expression of TNF mRNA CTD PMID:21870829 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of cinnamic acid
[TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of cinnamic acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
zimeldine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Zimeldine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Zimeldine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Zimeldine results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Zimeldine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Zimeldine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Zimeldine results in increased expression of FABP1 mRNA CTD PMID:17175557 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Zimeldine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Zimeldine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Hpn hepsin increases expression ISO Zimeldine results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Zimeldine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Zimeldine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lss lanosterol synthase increases expression ISO Zimeldine results in increased expression of LSS mRNA CTD PMID:17175557 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Zimeldine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Zimeldine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Zimeldine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Tagln transgelin decreases expression ISO Zimeldine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Zimeldine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          carbon atom 19748
            organic molecular entity 19748
              olefinic compound 16965
                styrenes 253
                  (1R)-(3-ethenylphenyl)-1,2-ethanediol 0
                  (1S)-(3-Ethenylphenyl)-1,2-ethanediol 0
                  (1Z,4Z)-1,5-bis(4-hydroxyphenyl)-1,4-pentadiene 0
                  (2E)-N-(3-aminopropyl)-3-(4-hydroxyphenyl)prop-2-enimidic acid 0
                  (2E)-N-(4-amino-2,3-dihydroxybutyl)-3-(4-hydroxyphenyl)prop-2-enimidic acid 0
                  (2E,4E)-5-[2-[(1E,3E,5E,7E)-nona-1,3,5,7-tetraenyl]phenyl]penta-2,4-dienoic acid 0
                  (2E,4E,6E,8E)-9-[2-[(1E,3E)-4-carboxybuta-1,3-dienyl]phenyl]nona-2,4,6,8-tetraenoic acid 0
                  (2E,4E,6S,8R,10E)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenylundeca-2,4,10-trienamide 0
                  (2RS,5RS)-(E)-2-(2-Phenylethenyl)-1,3-dioxan-5-ol 0
                  (E)-2-phenylethenesulfonamide 0
                  (E)-3-(trifluoromethyl)cinnamic acid + 0
                  (E)-4-phenylbut-3-enamide 0
                  (R)-styrene glycol 0
                  (S)-styrene glycol 0
                  (Z)-4-(1-Propenyl)phenol 0
                  1,2-Divinylbenzene 0
                  1,3-diethenyl-Benzene 0
                  1-(2-phenylethenylsulfonyl)-2,3-dihydropyridin-6-one 0
                  1-Phenyl-1-butene 0
                  1-ethyl-6-methyl-3-(2-phenylethenyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione 0
                  2-(4-hydroxyphenyl)ethenyl hexadecanoate 0
                  2-(Styrylthio)acetic acid 0
                  2-Hydroxy-7,8-dehydrograndiflorone 0
                  2-[1-(1H-imidazol-1-yl)vinyl]phenol 0
                  2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)prop-1-enyl]pyridine 0
                  2-[2-(4-fluorophenyl)ethenyl]-5-thiophen-2-yl-1,3,4-oxadiazole 0
                  2-furanyl-[4-(3-phenylprop-2-enyl)-1-piperazinyl]methanone 0
                  2-methyl-6-(2-phenylethenyl)pyridine 0
                  3,4-Dehydrochlorambucil 0
                  3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine 0
                  3-(Styrylthio)propanoic acid 0
                  3-[3-(2-bromophenyl)-1-hydroxyprop-2-enylidene]-6-methylpyran-2,4-dione 0
                  4-(2-Pyrazinylethenyl)phenol 0
                  4-Methylstyrene 0
                  4-Vinylaniline 0
                  4-[2-(1-hexyl-2-pyridin-1-iumyl)ethenyl]-N,N-dimethylaniline 0
                  4-[2-(4-bromophenyl)ethenyl]-1-methylpyridin-1-ium 0
                  4-ethenyl-1,2-dimethylbenzene 0
                  4-styrylpyridine 0
                  4-vinylguaiacol sulfate 0
                  4-vinylphenol sulfate 0
                  5-Benzyl-2,2-dimethyl-5-(4-vinylbenzyl)-1,3-dioxane-4,6-dione 0
                  5-methyl-1-phenylhexen-3-yn-5-ol 0
                  5-phenylpenta-2,4-dienoic acid 0
                  6-hydroxy-7-(3-phenylprop-2-enyl)-3,4-dihydro-2H-pyrimido[2,1-b][1,3]thiazin-8-one 0
                  9-Methoxystrobilurin E 0
                  9-methoxystrobilurin G 0
                  9-oxostrobilurin E 0
                  9-oxostrobilurin G 0
                  9-oxostrobilurin I 0
                  9-oxostrobilurin K 0
                  9-oxostrobulirin A 0
                  Aspopyrone A 0
                  Avenalumic acid 0
                  Benzene, 1-ethenyl-4-ethyl- 0
                  Bipolarisenol 0
                  Bis-noryangonin 0
                  Bisacremine A 0
                  Bisacremine B 0
                  Bisacremine C 0
                  Bisacremine D 0
                  Butenolide 5 0
                  Cinnamalacetone 0
                  Cinnamyl butyrate 0
                  Cinnamyl formate 0
                  Cinnamyl isobutyrate 0
                  Cinnamyl phenylacetate 0
                  Cinnamylideneacetone 0
                  Coumaroylcadaverine 0
                  Crocacin C 0
                  Dienomycin A 0
                  Dienomycin B 0
                  Dienomycin C 0
                  Fuligopyrone 0
                  Gombapyrone A 0
                  Gombapyrone B 0
                  Gombapyrone C 0
                  Gombapyrone D 0
                  Gombapyrone E 0
                  Gombapyrone F 0
                  Homopyrone A 0
                  Isoallylbenzene 0
                  LSM-15094 0
                  LSM-15100 0
                  LSM-15135 0
                  LSM-15153 0
                  LSM-17524 0
                  LSM-17556 0
                  LSM-17571 0
                  LSM-17615 0
                  LSM-17646 0
                  LSM-17675 0
                  LSM-17682 0
                  LSM-17721 0
                  LSM-21391 0
                  LSM-21397 0
                  LSM-21449 0
                  LSM-21472 0
                  LSM-21491 0
                  LSM-21567 0
                  LSM-21574 0
                  LSM-25308 0
                  LSM-25309 0
                  LSM-25344 0
                  LSM-25419 0
                  LSM-25429 0
                  LSM-25439 0
                  LSM-25489 0
                  LSM-25544 0
                  LSM-28114 0
                  LSM-30968 0
                  LSM-30988 0
                  LSM-31000 0
                  LSM-31003 0
                  LSM-31009 0
                  LSM-31020 0
                  LSM-31026 0
                  LSM-31057 0
                  LSM-31072 0
                  LSM-31075 0
                  LSM-31085 0
                  LSM-31092 0
                  LSM-31103 0
                  LSM-31104 0
                  LSM-31107 0
                  LSM-31113 0
                  LSM-31161 0
                  LSM-31162 0
                  LSM-31180 0
                  LSM-31192 0
                  LSM-31195 0
                  LSM-31205 0
                  LSM-38928 0
                  LSM-39159 0
                  LSM-41763 0
                  LSM-6844 0
                  LSM-6883 0
                  LSM-6899 0
                  LSM-6923 0
                  LSM-6945 0
                  LSM-6961 0
                  LSM-7221 0
                  LSM-7235 0
                  LSM-7256 0
                  LSM-7390 0
                  LSM-7408 0
                  LSM-7438 0
                  LSM-7450 0
                  LSM-7538 0
                  LSM-7566 0
                  LSM-7625 0
                  LSM-7644 0
                  LSM-7926 0
                  LSM-8083 0
                  Lahorenoic acid C 0
                  Lorneic acid A 0
                  Lorneic acid F 0
                  Lorneic acid J 0
                  Methylstyrylpyron 0
                  Munchiwarin 0
                  N'2-cinnamoyl-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide 0
                  N-(1,5-dimethyl-4-pyrazolyl)-3-phenyl-2-propen-1-imine 0
                  N-(cinnamylideneamino)carbamic acid ethyl ester 0
                  N-Methyl-N-(2-phenylethenyl)-3-phenyl-2-oxiranecarboxamide 0
                  N-[(E)-2-(4-Hydroxyphenyl)ethenyl]-3-methylbutanamide 0
                  N-[(E)-2-(4-hydroxyphenyl)ethenyl]hexadecanamide 0
                  N-[2-[(1-methyl-5-tetrazolyl)thio]ethyl]-3-phenyl-2-propen-1-amine 0
                  Navenone B 0
                  Navenone C 0
                  Oudemansin A 0
                  Oudemansin I 0
                  P-Hydroxystyrylamine 0
                  Phenylnannolone A 0
                  Phenylnannolone B 0
                  Phenylnannolone C 0
                  Solwaric acid B 0
                  Strobilurin E 0
                  Strobilurin G 0
                  Strobilurin I 0
                  Strobilurin K 0
                  Strobilurin O 0
                  Strobilurin P 0
                  Styrolide A 0
                  Styrolide B 0
                  Tunicatachalcone 0
                  WF-5239 0
                  Youbetaoufene B3 0
                  Youbetaoufene B4 0
                  \{[(2E)-3-(3-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                  \{[(2E)-3-(4-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                  \{[(3E)-2-oxo-4-phenylbut-3-en-1-yl]oxy\}sulfonic acid 0
                  \{[3-(2-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                  \{[3-(4-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                  chalcone + 132
                  cinnamic acid + 38
                  cis-5-caffeoyl-quinic acid 0
                  methyl 5-hydroxy-7-p-hydroxyphenysl-3-keto-4Z,6E-heptadienoate 0
                  mimosifolenone 0
                  n-trans-p-coumaroyloctopamine 0
                  nigerloxin 0
                  oxantel 0
                  p-Coumaroyl spermidine 0
                  spiculoic acid A 0
                  styrene + 119
                  trans,trans-1,4-Diphenyl-1,3-butadiene 0
                  zimeldine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                carbocyclic compound 18579
                                  benzenoid aromatic compound 18003
                                    benzenes 17868
                                      styrenes 253
                                        (1R)-(3-ethenylphenyl)-1,2-ethanediol 0
                                        (1S)-(3-Ethenylphenyl)-1,2-ethanediol 0
                                        (1Z,4Z)-1,5-bis(4-hydroxyphenyl)-1,4-pentadiene 0
                                        (2E)-N-(3-aminopropyl)-3-(4-hydroxyphenyl)prop-2-enimidic acid 0
                                        (2E)-N-(4-amino-2,3-dihydroxybutyl)-3-(4-hydroxyphenyl)prop-2-enimidic acid 0
                                        (2E,4E)-5-[2-[(1E,3E,5E,7E)-nona-1,3,5,7-tetraenyl]phenyl]penta-2,4-dienoic acid 0
                                        (2E,4E,6E,8E)-9-[2-[(1E,3E)-4-carboxybuta-1,3-dienyl]phenyl]nona-2,4,6,8-tetraenoic acid 0
                                        (2E,4E,6S,8R,10E)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenylundeca-2,4,10-trienamide 0
                                        (2RS,5RS)-(E)-2-(2-Phenylethenyl)-1,3-dioxan-5-ol 0
                                        (E)-2-phenylethenesulfonamide 0
                                        (E)-3-(trifluoromethyl)cinnamic acid + 0
                                        (E)-4-phenylbut-3-enamide 0
                                        (R)-styrene glycol 0
                                        (S)-styrene glycol 0
                                        (Z)-4-(1-Propenyl)phenol 0
                                        1,2-Divinylbenzene 0
                                        1,3-diethenyl-Benzene 0
                                        1-(2-phenylethenylsulfonyl)-2,3-dihydropyridin-6-one 0
                                        1-Phenyl-1-butene 0
                                        1-ethyl-6-methyl-3-(2-phenylethenyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione 0
                                        2-(4-hydroxyphenyl)ethenyl hexadecanoate 0
                                        2-(Styrylthio)acetic acid 0
                                        2-Hydroxy-7,8-dehydrograndiflorone 0
                                        2-[1-(1H-imidazol-1-yl)vinyl]phenol 0
                                        2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)prop-1-enyl]pyridine 0
                                        2-[2-(4-fluorophenyl)ethenyl]-5-thiophen-2-yl-1,3,4-oxadiazole 0
                                        2-furanyl-[4-(3-phenylprop-2-enyl)-1-piperazinyl]methanone 0
                                        2-methyl-6-(2-phenylethenyl)pyridine 0
                                        3,4-Dehydrochlorambucil 0
                                        3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine 0
                                        3-(Styrylthio)propanoic acid 0
                                        3-[3-(2-bromophenyl)-1-hydroxyprop-2-enylidene]-6-methylpyran-2,4-dione 0
                                        4-(2-Pyrazinylethenyl)phenol 0
                                        4-Methylstyrene 0
                                        4-Vinylaniline 0
                                        4-[2-(1-hexyl-2-pyridin-1-iumyl)ethenyl]-N,N-dimethylaniline 0
                                        4-[2-(4-bromophenyl)ethenyl]-1-methylpyridin-1-ium 0
                                        4-ethenyl-1,2-dimethylbenzene 0
                                        4-styrylpyridine 0
                                        4-vinylguaiacol sulfate 0
                                        4-vinylphenol sulfate 0
                                        5-Benzyl-2,2-dimethyl-5-(4-vinylbenzyl)-1,3-dioxane-4,6-dione 0
                                        5-methyl-1-phenylhexen-3-yn-5-ol 0
                                        5-phenylpenta-2,4-dienoic acid 0
                                        6-hydroxy-7-(3-phenylprop-2-enyl)-3,4-dihydro-2H-pyrimido[2,1-b][1,3]thiazin-8-one 0
                                        9-Methoxystrobilurin E 0
                                        9-methoxystrobilurin G 0
                                        9-oxostrobilurin E 0
                                        9-oxostrobilurin G 0
                                        9-oxostrobilurin I 0
                                        9-oxostrobilurin K 0
                                        9-oxostrobulirin A 0
                                        Aspopyrone A 0
                                        Avenalumic acid 0
                                        Benzene, 1-ethenyl-4-ethyl- 0
                                        Bipolarisenol 0
                                        Bis-noryangonin 0
                                        Bisacremine A 0
                                        Bisacremine B 0
                                        Bisacremine C 0
                                        Bisacremine D 0
                                        Butenolide 5 0
                                        Cinnamalacetone 0
                                        Cinnamyl butyrate 0
                                        Cinnamyl formate 0
                                        Cinnamyl isobutyrate 0
                                        Cinnamyl phenylacetate 0
                                        Cinnamylideneacetone 0
                                        Coumaroylcadaverine 0
                                        Crocacin C 0
                                        Dienomycin A 0
                                        Dienomycin B 0
                                        Dienomycin C 0
                                        Fuligopyrone 0
                                        Gombapyrone A 0
                                        Gombapyrone B 0
                                        Gombapyrone C 0
                                        Gombapyrone D 0
                                        Gombapyrone E 0
                                        Gombapyrone F 0
                                        Homopyrone A 0
                                        Isoallylbenzene 0
                                        LSM-15094 0
                                        LSM-15100 0
                                        LSM-15135 0
                                        LSM-15153 0
                                        LSM-17524 0
                                        LSM-17556 0
                                        LSM-17571 0
                                        LSM-17615 0
                                        LSM-17646 0
                                        LSM-17675 0
                                        LSM-17682 0
                                        LSM-17721 0
                                        LSM-21391 0
                                        LSM-21397 0
                                        LSM-21449 0
                                        LSM-21472 0
                                        LSM-21491 0
                                        LSM-21567 0
                                        LSM-21574 0
                                        LSM-25308 0
                                        LSM-25309 0
                                        LSM-25344 0
                                        LSM-25419 0
                                        LSM-25429 0
                                        LSM-25439 0
                                        LSM-25489 0
                                        LSM-25544 0
                                        LSM-28114 0
                                        LSM-30968 0
                                        LSM-30988 0
                                        LSM-31000 0
                                        LSM-31003 0
                                        LSM-31009 0
                                        LSM-31020 0
                                        LSM-31026 0
                                        LSM-31057 0
                                        LSM-31072 0
                                        LSM-31075 0
                                        LSM-31085 0
                                        LSM-31092 0
                                        LSM-31103 0
                                        LSM-31104 0
                                        LSM-31107 0
                                        LSM-31113 0
                                        LSM-31161 0
                                        LSM-31162 0
                                        LSM-31180 0
                                        LSM-31192 0
                                        LSM-31195 0
                                        LSM-31205 0
                                        LSM-38928 0
                                        LSM-39159 0
                                        LSM-41763 0
                                        LSM-6844 0
                                        LSM-6883 0
                                        LSM-6899 0
                                        LSM-6923 0
                                        LSM-6945 0
                                        LSM-6961 0
                                        LSM-7221 0
                                        LSM-7235 0
                                        LSM-7256 0
                                        LSM-7390 0
                                        LSM-7408 0
                                        LSM-7438 0
                                        LSM-7450 0
                                        LSM-7538 0
                                        LSM-7566 0
                                        LSM-7625 0
                                        LSM-7644 0
                                        LSM-7926 0
                                        LSM-8083 0
                                        Lahorenoic acid C 0
                                        Lorneic acid A 0
                                        Lorneic acid F 0
                                        Lorneic acid J 0
                                        Methylstyrylpyron 0
                                        Munchiwarin 0
                                        N'2-cinnamoyl-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide 0
                                        N-(1,5-dimethyl-4-pyrazolyl)-3-phenyl-2-propen-1-imine 0
                                        N-(cinnamylideneamino)carbamic acid ethyl ester 0
                                        N-Methyl-N-(2-phenylethenyl)-3-phenyl-2-oxiranecarboxamide 0
                                        N-[(E)-2-(4-Hydroxyphenyl)ethenyl]-3-methylbutanamide 0
                                        N-[(E)-2-(4-hydroxyphenyl)ethenyl]hexadecanamide 0
                                        N-[2-[(1-methyl-5-tetrazolyl)thio]ethyl]-3-phenyl-2-propen-1-amine 0
                                        Navenone B 0
                                        Navenone C 0
                                        Oudemansin A 0
                                        Oudemansin I 0
                                        P-Hydroxystyrylamine 0
                                        Phenylnannolone A 0
                                        Phenylnannolone B 0
                                        Phenylnannolone C 0
                                        Solwaric acid B 0
                                        Strobilurin E 0
                                        Strobilurin G 0
                                        Strobilurin I 0
                                        Strobilurin K 0
                                        Strobilurin O 0
                                        Strobilurin P 0
                                        Styrolide A 0
                                        Styrolide B 0
                                        Tunicatachalcone 0
                                        WF-5239 0
                                        Youbetaoufene B3 0
                                        Youbetaoufene B4 0
                                        \{[(2E)-3-(3-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                                        \{[(2E)-3-(4-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                                        \{[(3E)-2-oxo-4-phenylbut-3-en-1-yl]oxy\}sulfonic acid 0
                                        \{[3-(2-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                                        \{[3-(4-hydroxyphenyl)prop-2-en-1-yl]oxy\}sulfonic acid 0
                                        chalcone + 132
                                        cinnamic acid + 38
                                        cis-5-caffeoyl-quinic acid 0
                                        methyl 5-hydroxy-7-p-hydroxyphenysl-3-keto-4Z,6E-heptadienoate 0
                                        mimosifolenone 0
                                        n-trans-p-coumaroyloctopamine 0
                                        nigerloxin 0
                                        oxantel 0
                                        p-Coumaroyl spermidine 0
                                        spiculoic acid A 0
                                        styrene + 119
                                        trans,trans-1,4-Diphenyl-1,3-butadiene 0
                                        zimeldine 17
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