steroid lactone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	steroid lactone	go back to main search page
Accession:	CHEBI:26766	browse the term
Synonyms:	related_synonym:	steroid lactones
	xref:	kegg.compound:C15507

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Rat (722 ) Mouse (736 ) Human (798 ) Chinchilla (0 ) Bonobo (0 ) Dog (22 ) Squirrel (0 ) Pig (2 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (722)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AE binding protein 1

multiple interactions
decreases expression

ISO

[Dactinomycin co-treated with arenobufagin] results in decreased stability of AEBP1 mRNA; AEBP1 protein inhibits the reaction [MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of GPX4 protein]]; AEBP1 protein inhibits the reaction [MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of SLC7A11 protein]]; MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of AEBP1 protein]
arenobufagin results in decreased expression of AEBP1 mRNA; arenobufagin results in decreased expression of AEBP1 protein

NCBI chr14:84,951,577...84,962,840
Ensembl chr14:84,952,822...84,962,843

G

glutathione peroxidase 4

decreases expression
multiple interactions

ISO

arenobufagin results in decreased expression of GPX4 protein
AEBP1 protein inhibits the reaction [MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of GPX4 protein]]; MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of GPX4 protein]

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

solute carrier family 7 member 11

multiple interactions
decreases expression

ISO

AEBP1 protein inhibits the reaction [MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of SLC7A11 protein]]; MIR149 mRNA promotes the reaction [arenobufagin results in decreased expression of SLC7A11 protein]

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

thymidylate synthetase

decreases expression

ISO

arenobufagin results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions
increases metabolic processing
increases activity

ISO

bufogenin results in increased expression of CYP3A4 mRNA
bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]
bufogenin results in increased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

thymidylate synthetase

decreases expression

ISO

bufogenin results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

decreases expression

ISO

bufotalin results in decreased expression of ABO mRNA

NCBI chr 3:30,560,172...30,604,758

G

abraxas 1, BRCA1 A complex subunit

decreases expression

ISO

bufotalin results in decreased expression of ABRAXAS1 mRNA

NCBI chr14:9,100,650...9,115,012
Ensembl chr14:9,100,671...9,115,011

G

1-aminocyclopropane-1-carboxylate synthase

decreases expression

ISO

bufotalin results in decreased expression of ACCS mRNA

NCBI chr 3:100,261,940...100,276,400
Ensembl chr 3:100,261,941...100,296,514

G

actin alpha 2, smooth muscle

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

activin A receptor type 1B

increases expression

ISO

bufotalin results in increased expression of ACVR1B mRNA

NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:134,164,991...134,208,388

G

ADAM metallopeptidase domain 11

increases expression

ISO

bufotalin results in increased expression of ADAM11 mRNA

NCBI chr10:88,224,185...88,242,865
Ensembl chr10:88,224,347...88,242,864

G

ADAM metallopeptidase with thrombospondin type 1 motif, 10

decreases expression

ISO

bufotalin results in decreased expression of ADAMTS10 mRNA

NCBI chr 7:15,033,859...15,063,800
Ensembl chr 7:15,033,934...15,063,800

G

ArfGAP with dual PH domains 1

decreases expression

ISO

bufotalin results in decreased expression of ADAP1 mRNA

NCBI chr12:20,438,091...20,489,961
Ensembl chr12:20,438,063...20,495,020

G

adhesion G protein-coupled receptor D1

decreases expression

ISO

bufotalin results in decreased expression of ADGRD1 mRNA

NCBI chr12:33,124,981...33,239,778
Ensembl chr12:33,125,915...33,272,509

G

angiotensin II receptor-associated protein

decreases expression

ISO

bufotalin results in decreased expression of AGTRAP mRNA

NCBI chr 5:163,790,565...163,802,174
Ensembl chr 5:163,791,887...163,802,174

G

AKT serine/threonine kinase 1

multiple interactions

ISO

bufotalin results in decreased expression of and results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

anaphase-promoting complex subunit 5

increases expression

ISO

bufotalin results in increased expression of ANAPC5 mRNA

NCBI chr12:39,409,519...39,442,518
Ensembl chr12:39,385,399...39,442,762

G

annexin A4

decreases expression

ISO

bufotalin results in decreased expression of ANXA4 mRNA

NCBI chr 4:120,741,750...120,798,534
Ensembl chr 4:120,741,750...120,798,513

G

aldehyde oxidase 1

increases expression

ISO

bufotalin results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

adenine phosphoribosyl transferase

increases expression

ISO

bufotalin results in increased expression of APRT mRNA

NCBI chr19:67,534,737...67,537,027

G

Rho guanine nucleotide exchange factor 40

decreases expression

ISO

bufotalin results in decreased expression of ARHGEF40 mRNA

NCBI chr15:27,146,155...27,170,012
Ensembl chr15:27,146,197...27,170,012

G

ARVCF, delta catenin family member

increases expression

ISO

bufotalin results in increased expression of ARVCF mRNA

NCBI chr11:96,092,451...96,150,144
Ensembl chr11:96,092,451...96,150,163

G

ATP synthase F1 subunit alpha

decreases expression

ISO

bufotalin results in decreased expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATP synthase membrane subunit f

increases expression

ISO

bufotalin results in increased expression of ATP5MF mRNA

NCBI chr12:14,535,435...14,542,007
Ensembl chr12:14,522,832...14,542,709

G

ATP synthase peripheral stalk-membrane subunit b

decreases expression

ISO

bufotalin results in decreased expression of ATP5PB mRNA

NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387

G

ATPase H+ transporting V0 subunit B

increases expression

ISO

bufotalin results in increased expression of ATP6V0B mRNA

NCBI chr 5:136,708,823...136,710,339
Ensembl chr 5:136,708,823...136,716,828

G

ATPase copper transporting beta

decreases expression

ISO

bufotalin results in decreased expression of ATP7B mRNA

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

ATP synthase c subunit lysine N-methyltransferase

decreases expression

ISO

bufotalin results in decreased expression of ATPSCKMT mRNA

NCBI chr 2:84,313,991...84,329,195
Ensembl chr 2:84,313,921...84,329,194

G

aurora kinase A

decreases expression

ISO

bufotalin results in decreased expression of AURKA protein

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

bufotalin results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

bufotalin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 10

multiple interactions

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased expression of BCL2L10 protein

NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:84,987,833...84,993,872

G

BCL9, transcription coactivator

decreases expression

ISO

bufotalin results in decreased expression of BCL9 mRNA

NCBI chr 2:187,449,425...187,475,241
Ensembl chr 2:187,449,425...187,475,241

G

BCL9 like

increases expression

ISO

bufotalin results in increased expression of BCL9L mRNA

NCBI chr 8:53,708,770...53,738,880
Ensembl chr 8:53,708,770...53,737,395

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

ISO

bufotalin results in decreased expression of BDH1 mRNA

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

BH3 interacting domain death agonist

multiple interactions

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased expression of BID protein; bufotalin affects the reaction [TNF protein affects the expression of BID protein]; bufotalin affects the reaction [TNFSF10 protein affects the expression of BID protein]

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

baculoviral IAP repeat-containing 5

multiple interactions

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BRCA1, DNA repair associated

increases expression

ISO

bufotalin results in increased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

similar to human chromosome 2 open reading frame 92

increases expression

ISO

bufotalin results in increased expression of C2ORF92 mRNA

NCBI chr 9:46,439,554...46,480,735
Ensembl chr 9:46,440,408...46,480,733

G

calcyphosine 2

decreases expression

ISO

bufotalin results in decreased expression of CAPS2 mRNA

NCBI chr 7:49,467,320...49,525,465
Ensembl chr 7:49,464,885...49,525,465

G

caspase 12

multiple interactions

ISO

benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bufotalin results in increased activity of CASP12 protein]; bufotalin results in increased activity of and results in increased cleavage of CASP12 protein

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases cleavage
multiple interactions

ISO

bufotalin results in increased cleavage of CASP3 protein
bufotalin promotes the reaction [TNF protein results in increased cleavage of CASP3 protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]

PMID:21887462 PMID:22841670 PMID:37836626

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions

ISO

bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions

ISO

bufotalin promotes the reaction [TNF protein results in increased cleavage of CASP8 protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage

ISO

bufotalin results in increased cleavage of CASP9 protein

PMID:22841670 PMID:37836626

Ensembl chr 5:159,391,188...159,409,648

G

cystathionine beta synthase

decreases expression

ISO

bufotalin results in decreased expression of CBS mRNA

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066

G

coiled-coil domain containing 17

increases expression

ISO

bufotalin results in increased expression of CCDC17 mRNA

NCBI chr 5:135,288,799...135,293,339
Ensembl chr 5:135,289,576...135,293,336

G

cellular communication network factor 2

multiple interactions

ISO

bufotalin inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]
bufotalin inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A1

decreases expression

ISO

bufotalin results in decreased expression of CCNA1 protein

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin B1

decreases expression

ISO

bufotalin results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin G1

increases expression

ISO

bufotalin results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

Cd82 molecule

decreases expression

ISO

bufotalin results in decreased expression of CD82 mRNA

NCBI chr 3:99,842,748...99,887,298
Ensembl chr 3:99,842,757...99,886,744

G

cell division cycle 25A

decreases expression

ISO

bufotalin results in decreased expression of CDC25A protein

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

CDC42 small effector 2

decreases expression

ISO

bufotalin results in decreased expression of CDC42SE2 mRNA

NCBI chr10:39,337,269...39,405,772
Ensembl chr 1:100,424,547...100,424,801
Ensembl chr10:100,424,547...100,424,801

G

cadherin 1

multiple interactions
increases expression

ISO

bufotalin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
bufotalin results in increased expression of CDH1 protein

PMID:37836626 PMID:38158113

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 2

decreases expression

ISO

bufotalin results in decreased expression of CDH2 protein

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase 1

decreases expression

ISO

bufotalin results in decreased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 20

decreases expression

ISO

bufotalin results in decreased expression of CDK20 mRNA

NCBI chr17:706,863...717,828
Ensembl chr17:706,865...713,567

G

CDK5 regulatory subunit associated protein 1

affects expression

ISO

bufotalin affects the expression of CDK5RAP1 mRNA

NCBI chr 3:163,189,435...163,333,003
Ensembl chr 3:163,191,056...163,332,908

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

bufotalin results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

centromere protein T

increases expression

ISO

bufotalin results in increased expression of CENPT mRNA

NCBI chr19:50,644,548...50,651,048
Ensembl chr19:50,634,368...50,651,037

G

ceramide synthase 2

increases expression

ISO

bufotalin results in increased expression of CERS2 mRNA

NCBI chr 2:185,579,511...185,587,789
Ensembl chr 2:185,579,119...185,588,839

G

craniofacial development protein 1

increases expression

ISO

bufotalin results in increased expression of CFDP1 mRNA

NCBI chr19:56,627,596...56,733,099
Ensembl chr19:56,626,963...56,733,098

G

chromodomain helicase DNA binding protein 4

increases expression

ISO

bufotalin results in increased expression of CHD4 mRNA

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

creatine kinase B

increases expression

ISO

bufotalin results in increased expression of CKB mRNA

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

calmin

decreases expression

ISO

bufotalin results in decreased expression of CLMN mRNA

NCBI chr 6:129,470,613...129,572,079
Ensembl chr 6:129,478,149...129,572,027

G

carboxymethylenebutenolidase homolog

decreases expression

ISO

bufotalin results in decreased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

collagen type I alpha 1 chain

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

carnitine palmitoyltransferase 1c

decreases expression

ISO

bufotalin results in decreased expression of CPT1C mRNA

NCBI chr 1:104,579,297...104,593,824
Ensembl chr 1:104,579,298...104,593,763

G

colony stimulating factor 2 receptor subunit alpha

increases expression

ISO

bufotalin results in increased expression of CSF2RA mRNA

NCBI chr14:113,219...118,808
Ensembl chr14:113,225...118,117

G

casein kinase 2 alpha 1

increases expression

ISO

bufotalin results in increased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

CTD small phosphatase 1

decreases expression

ISO

bufotalin results in decreased expression of CTDSP1 mRNA

NCBI chr 9:83,422,755...83,428,411
Ensembl chr 9:83,423,051...83,428,412

G

catenin beta 1

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cullin 9

increases expression

ISO

bufotalin results in increased expression of CUL9 mRNA

NCBI chr 9:21,933,699...21,977,145
Ensembl chr 9:21,933,803...21,977,145

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation

ISO

CYP3A4 protein results in increased hydroxylation of bufotalin

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases hydroxylation

ISO

CYP3A5 protein results in increased hydroxylation of bufotalin

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily f, polypeptide 18

decreases expression

ISO

bufotalin results in decreased expression of CYP4F3 mRNA

NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958

G

cytohesin 1

increases expression

ISO

bufotalin results in increased expression of CYTH1 mRNA

NCBI chr10:103,901,376...103,984,496
Ensembl chr10:103,864,804...103,984,383

G

DAB adaptor protein 2

increases expression

ISO

bufotalin results in increased expression of DAB2 mRNA

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888

G

discoidin, CUB and LCCL domain containing 1

decreases expression

ISO

bufotalin results in decreased expression of DCBLD1 mRNA

NCBI chr20:32,161,241...32,254,391
Ensembl chr20:32,161,254...32,281,176

G

DNA-damage inducible transcript 3

increases expression

ISO

bufotalin results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DEAD-box helicase 3, X-linked

increases expression

ISO

bufotalin results in increased expression of DDX3X mRNA

NCBI chr X:12,152,346...12,165,983
Ensembl chr X:12,152,346...12,165,983

G

DEAD-box helicase 56

decreases expression

ISO

bufotalin results in decreased expression of DDX56 mRNA

NCBI chr14:85,325,942...85,336,262
Ensembl chr14:85,325,942...85,336,262

G

desmin

decreases expression

ISO

bufotalin results in decreased expression of DES mRNA

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

DIO3 opposite strand upstream RNA

increases expression

ISO

bufotalin results in increased expression of DIO3OS mRNA

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

ISO

bufotalin results in increased expression of DKK1 mRNA

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

delta like canonical Notch ligand 4

increases expression

ISO

bufotalin results in increased expression of DLL4 mRNA

NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:126,770,794...126,780,763

G

doublesex and mab-3 related transcription factor 1

increases expression

ISO

bufotalin results in increased expression of DMRT1 mRNA

NCBI chr 1:232,569,179...232,667,646
Ensembl chr 1:232,569,072...232,668,370

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

ISO

bufotalin results in decreased expression of DNAJB14 mRNA

NCBI chr 2:229,032,415...229,075,905
Ensembl chr 2:229,032,286...229,075,922

G

dynein heavy chain domain 1

decreases expression

ISO

bufotalin results in decreased expression of DNHD1 mRNA

NCBI chr 1:169,402,615...169,486,684
Ensembl chr 1:169,394,884...169,487,646

G

DOP1 leucine zipper like protein A

increases expression

ISO

bufotalin results in increased expression of DOP1A mRNA

NCBI chr 8:96,295,302...96,397,951
Ensembl chr 8:96,295,328...96,398,652

G

dipeptidase 1

decreases expression

ISO

bufotalin results in decreased expression of DPEP1 mRNA

NCBI chr19:68,118,270...68,143,781
Ensembl chr19:68,118,453...68,143,775

G

enoyl CoA hydratase domain containing 2

decreases expression

ISO

bufotalin results in decreased expression of ECHDC2 mRNA

NCBI chr 5:128,144,241...128,163,611
Ensembl chr 5:128,144,425...128,163,610

G

estrogen-induced osteoclastogenesis regulator 1

increases expression

ISO

bufotalin results in increased expression of FAM102A mRNA

NCBI chr 3:36,220,170...36,252,377
Ensembl chr 3:36,211,730...36,252,378

G

EF-hand calcium binding domain 2

decreases expression

ISO

bufotalin results in decreased expression of EFCAB2 mRNA

NCBI chr13:92,683,182...92,769,939
Ensembl chr13:92,684,086...92,782,558

G

ephrin A1

increases expression

ISO

bufotalin results in increased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

ISO

bufotalin results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2B subunit epsilon

increases expression

ISO

bufotalin results in increased expression of EIF2B5 mRNA

NCBI chr11:93,898,814...93,909,431
Ensembl chr11:93,898,814...93,908,800

G

eukaryotic translation initiation factor 4, gamma 2

decreases expression

ISO

bufotalin results in decreased expression of EIF4G2 mRNA

NCBI chr 1:174,616,102...174,628,252
Ensembl chr 1:174,616,103...174,628,252

G

ELOVL fatty acid elongase 1

affects expression

ISO

bufotalin affects the expression of ELOVL1 mRNA

NCBI chr 5:137,246,781...137,251,351
Ensembl chr 5:137,246,849...137,251,352

G

elongator acetyltransferase complex subunit 3

increases expression

ISO

bufotalin results in increased expression of ELP3 mRNA

NCBI chr15:43,930,234...43,992,065
Ensembl chr15:43,930,234...43,992,214

G

endosome associated trafficking regulator 1

decreases expression

ISO

bufotalin results in decreased expression of ENTR1 mRNA

NCBI chr 3:29,599,059...29,605,780
Ensembl chr 3:29,599,059...29,605,898

G

epoxide hydrolase 2

decreases expression

ISO

bufotalin results in decreased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

ETS transcription factor ERG

decreases expression

ISO

bufotalin results in decreased expression of ERG mRNA

NCBI chr11:48,148,149...48,370,472
Ensembl chr11:48,148,153...48,370,688

G

ERH, mRNA splicing and mitosis factor

increases expression

ISO

bufotalin results in increased expression of ERH mRNA

NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:106,012,255...106,022,623

G

endoplasmic reticulum metallopeptidase 1

decreases expression

ISO

bufotalin results in decreased expression of ERMP1 mRNA

NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:236,801,466...236,839,197

G

endoplasmic reticulum to nucleus signaling 1

increases phosphorylation

ISO

bufotalin results in increased phosphorylation of ERN1 protein

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

exosome component 2

decreases expression

ISO

bufotalin results in decreased expression of EXOSC2 mRNA

NCBI chr 3:35,360,652...35,370,948
Ensembl chr 3:35,360,666...35,371,373

G

fumarylacetoacetate hydrolase

decreases expression

ISO

bufotalin results in decreased expression of FAH mRNA

NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:147,957,935...147,981,046

G

family with sequence similarity 98, member C

decreases expression

ISO

bufotalin results in decreased expression of FAM98C mRNA

NCBI chr 1:93,580,286...93,583,894
Ensembl chr 1:93,580,287...93,583,831

G

FANCD2 and FANCI associated nuclease 1

decreases expression

ISO

bufotalin results in decreased expression of FAN1 mRNA

NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:127,330,016...127,356,400

G

Fas cell surface death receptor

increases expression

ISO

bufotalin results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box and leucine-rich repeat protein 2

increases expression

ISO

bufotalin results in increased expression of FBXL2 mRNA

NCBI chr 8:122,794,870...122,843,265
Ensembl chr 8:122,794,870...122,854,798

G

farnesyl diphosphate synthase

decreases expression

ISO

bufotalin results in decreased expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

FOXF1 adjacent non-coding developmental regulatory RNA

affects expression

ISO

bufotalin affects the expression of FENDRR mRNA

NCBI chr19:66,035,910...66,061,466
Ensembl chr19:66,036,856...66,044,268

G

FGGY carbohydrate kinase domain containing

decreases expression

ISO

bufotalin results in decreased expression of FGGY mRNA

NCBI chr 5:115,514,573...115,901,713
Ensembl chr 5:115,472,211...115,901,714

G

fibronectin 1

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

forkhead box P2

decreases expression

ISO

bufotalin results in decreased expression of FOXP2 mRNA

NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696

G

fibronectin type III and SPRY domain containing 1

decreases expression

ISO

bufotalin results in decreased expression of FSD1 mRNA

NCBI chr 9:905,418...908,938
Ensembl chr 9:905,430...915,364

G

FTX transcript, XIST regulator

decreases expression

ISO

bufotalin results in decreased expression of FTX mRNA

NCBI chr X:72,654,112...72,696,097

G

GINS complex subunit 3

increases expression

ISO

bufotalin results in increased expression of GINS3 mRNA

NCBI chr19:9,426,140...9,435,192
Ensembl chr19:9,399,759...9,434,679

G

glutamate-ammonia ligase

decreases expression

ISO

bufotalin results in decreased expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

N-acetylglucosamine-1-phosphate transferase subunit gamma

increases expression

ISO

bufotalin results in increased expression of GNPTG mRNA

NCBI chr10:14,756,685...14,761,636

G

glutathione peroxidase 8

increases expression

ISO

bufotalin results in increased expression of GPX8 mRNA

NCBI chr 2:46,409,646...46,413,401
Ensembl chr 2:46,409,139...46,413,406

G

glutamate receptor interacting protein 2

decreases expression

ISO

bufotalin results in decreased expression of GRIP2 mRNA

NCBI chr 4:125,828,609...125,913,693
Ensembl chr 4:125,828,609...125,913,750

G

GrpE-like 2, mitochondrial

increases expression

ISO

bufotalin results in increased expression of GRPEL2 mRNA

NCBI chr18:57,438,168...57,450,408
Ensembl chr18:57,438,168...57,450,717

G

glycogen synthase kinase 3 beta

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione S-transferase mu 4

decreases expression

ISO

bufotalin results in decreased expression of GSTM4 mRNA

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638

G

glutathione S-transferase pi 1

increases expression

ISO

bufotalin results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

general transcription factor 2A subunit 2

increases expression

ISO

bufotalin results in increased expression of GTF2A2 mRNA

NCBI chr 8:79,542,682...79,556,484
Ensembl chr 8:79,547,307...79,565,408

G

guanylate kinase 1

increases expression

ISO

bufotalin results in increased expression of GUK1 mRNA

NCBI chr10:44,471,075...44,488,332
Ensembl chr10:44,471,085...44,479,355

G

heparin binding growth factor

increases expression

ISO

bufotalin results in increased expression of HDGF mRNA

NCBI chr 2:175,668,290...175,677,614
Ensembl chr 2:175,668,324...175,677,225

G

homeostatic iron regulator

decreases expression

ISO

bufotalin results in decreased expression of HFE mRNA

NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,841,252...41,851,208

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

ISO

bufotalin results in increased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

HIVEP zinc finger 3

increases expression

ISO

bufotalin results in increased expression of HIVEP3 mRNA

NCBI chr 5:138,610,592...139,013,058
Ensembl chr 5:138,943,312...139,010,430

G

hydroxysteroid (17-beta) dehydrogenase 7

decreases expression

ISO

bufotalin results in decreased expression of HSD17B7 mRNA

NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754

G

heat shock protein family A (Hsp70) member 8

increases expression

ISO

bufotalin results in increased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

increases expression

ISO

bufotalin results in increased expression of IDH3A mRNA

NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:63,867,820...63,887,223

G

interferon gamma

decreases secretion

ISO

bufotalin results in decreased secretion of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

intraflagellar transport 140

increases expression

ISO

bufotalin results in increased expression of IFT140 mRNA

NCBI chr10:14,537,134...14,624,926
Ensembl chr10:14,537,466...14,624,926

G

interleukin 10

decreases secretion
multiple interactions

ISO

bufotalin results in decreased secretion of IL10 protein
bufotalin inhibits the reaction [Bleomycin results in increased expression of IL10 protein]; bufotalin inhibits the reaction [Ovalbumin results in increased secretion of IL10 protein]
bufotalin inhibits the reaction [TGFB1 protein results in increased expression of IL10 mRNA]

PMID:31950221 PMID:36455750 PMID:38158113

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 13

multiple interactions

ISO

bufotalin inhibits the reaction [Bleomycin results in increased expression of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 17A

decreases secretion

ISO

bufotalin results in decreased secretion of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17 receptor C

decreases expression

ISO

bufotalin results in decreased expression of IL17RC mRNA

NCBI chr 4:148,174,573...148,187,071
Ensembl chr 4:148,174,578...148,187,068

G

interleukin 1 beta

decreases secretion
multiple interactions

ISO

bufotalin results in decreased secretion of IL1B protein
bufotalin inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; bufotalin inhibits the reaction [Ovalbumin results in increased secretion of IL1B protein]

PMID:31950221 PMID:36455750 PMID:38158113

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

decreases secretion

ISO

bufotalin results in decreased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol monophosphatase 1

increases expression

ISO

bufotalin results in increased expression of IMPA1 mRNA

NCBI chr 2:93,370,200...93,391,474
Ensembl chr 2:93,370,299...93,391,468

G

interferon stimulated exonuclease gene 20

decreases expression

ISO

bufotalin results in decreased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401

G

ISY1 splicing factor homolog

increases expression

ISO

bufotalin results in increased expression of ISY1 mRNA

NCBI chr 4:121,833,870...121,854,561
Ensembl chr 4:121,806,992...121,854,561

G

integrin subunit alpha 6

decreases expression

ISO

bufotalin results in decreased expression of ITGA6 protein

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

Janus kinase 3

decreases expression

ISO

bufotalin results in decreased expression of JAK3 mRNA

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222

G

junctophilin 3

decreases expression

ISO

bufotalin results in decreased expression of JPH3 mRNA

NCBI chr19:66,702,497...66,763,948
Ensembl chr19:66,702,680...66,763,937

G

lysine acetyltransferase 6A

increases expression

ISO

bufotalin results in increased expression of KAT6A mRNA

NCBI chr16:75,787,411...75,868,584
Ensembl chr16:75,787,411...75,866,099

G

lysine demethylase 3A

increases expression

ISO

bufotalin results in increased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

lysine demethylase 5B

decreases expression

ISO

bufotalin results in decreased expression of KDM5B mRNA

NCBI chr13:48,554,367...48,625,721
Ensembl chr13:48,554,420...48,626,423

G

kinesin family member 17

increases expression

ISO

bufotalin results in increased expression of KIF17 mRNA

NCBI chr 5:155,765,592...155,802,941
Ensembl chr 5:155,765,592...155,803,247

G

kynurenine aminotransferase 3

decreases expression

ISO

bufotalin results in decreased expression of KYAT3 mRNA

NCBI chr 2:234,362,306...234,407,646
Ensembl chr 2:234,362,322...234,407,878

G

L3MBTL histone methyl-lysine binding protein 2

decreases expression

ISO

bufotalin results in decreased expression of L3MBTL2 mRNA

NCBI chr 7:115,066,427...115,087,625
Ensembl chr 7:115,066,486...115,087,598

G

laminin subunit alpha 1

increases expression

ISO

bufotalin results in increased expression of LAMA1 mRNA

NCBI chr 9:115,139,548...115,263,620
Ensembl chr 9:115,139,548...115,264,251

G

La ribonucleoprotein 1B

decreases expression

ISO

bufotalin results in decreased expression of LARP1B mRNA

NCBI chr 2:125,860,935...125,897,189
Ensembl chr 2:125,863,997...125,897,189

G

lipoprotein lipase

increases expression

ISO

bufotalin results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine rich repeat containing 29

decreases expression

ISO

bufotalin results in decreased expression of LRRC29 mRNA

NCBI chr19:50,098,274...50,113,488
Ensembl chr19:50,098,275...50,113,437

G

mitogen-activated protein kinase 12

increases expression

ISO

bufotalin results in increased expression of MAPK12 mRNA

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen-activated protein kinase 15

decreases expression

ISO

bufotalin results in decreased expression of MAPK15 mRNA

NCBI chr 7:109,575,619...109,595,339
Ensembl chr 7:109,575,561...109,595,346

G

mitogen-activated protein kinase 8 interacting protein 3

increases expression

ISO

bufotalin results in increased expression of MAPK8IP3 mRNA

NCBI chr10:14,422,936...14,463,387
Ensembl chr10:14,422,936...14,462,812

G

methyl-CpG binding domain protein 5

decreases expression

ISO

bufotalin results in decreased expression of MBD5 mRNA

NCBI chr 3:53,742,458...54,147,970
Ensembl chr 3:54,075,084...54,139,389

G

malic enzyme 2

decreases expression

ISO

bufotalin results in decreased expression of ME2 mRNA

NCBI chr18:69,626,073...69,676,218
Ensembl chr18:69,626,087...69,676,218

G

muskelin 1

increases expression

ISO

bufotalin results in increased expression of MKLN1 mRNA

NCBI chr 4:60,939,239...61,095,214
Ensembl chr 4:60,937,817...61,095,210

G

matrix metallopeptidase 2

decreases expression

ISO

bufotalin results in decreased expression of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 7

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

matrix metallopeptidase 9

decreases expression

ISO

bufotalin results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

maestro heat-like repeat family member 6

decreases expression

ISO

bufotalin results in decreased expression of MROH6 mRNA

NCBI chr 7:109,448,738...109,456,034
Ensembl chr 7:109,449,268...109,455,087

G

mitochondrial ribosomal protein S16

decreases expression

ISO

bufotalin results in decreased expression of MRPS16 mRNA

NCBI chr15:3,967,809...3,970,211
Ensembl chr15:3,968,054...3,970,185

G

myotubularin related protein 11

decreases expression

ISO

bufotalin results in decreased expression of MTMR11 mRNA

NCBI chr 2:186,410,851...186,421,024
Ensembl chr 2:186,412,291...186,421,026

G

mitochondrial translation release factor 1 like

increases expression

ISO

bufotalin results in increased expression of MTRF1L mRNA

NCBI chr 1:44,614,162...44,626,367
Ensembl chr 1:44,615,921...44,626,178

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

increases expression

ISO

bufotalin results in increased expression of MTRR mRNA

NCBI chr 1:36,695,376...36,727,341
Ensembl chr 1:36,695,460...36,727,807

G

murinoglobulin 6

decreases expression

ISO

bufotalin results in decreased expression of CPAMD8 mRNA

NCBI chr 4:157,004,905...157,085,187
Ensembl chr 4:157,004,905...157,085,250

G

myosin binding protein H-like

decreases expression

ISO

bufotalin results in decreased expression of MYBPHL mRNA

NCBI chr 2:198,692,857...198,706,953
Ensembl chr 2:198,693,101...198,705,738

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of MYC mRNA]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin X

decreases expression

ISO

bufotalin results in decreased expression of MYO10 mRNA

NCBI chr 2:77,831,532...78,036,137
Ensembl chr 2:77,831,532...78,036,137

G

myosin XVIIIa

increases expression

ISO

bufotalin results in increased expression of MYO18A mRNA

NCBI chr10:63,152,303...63,253,543
Ensembl chr10:63,152,103...63,253,543

G

NADH:ubiquinone oxidoreductase subunit B5

decreases expression

ISO

bufotalin results in decreased expression of NDUFB5 mRNA

NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:117,447,035...117,461,590

G

nebulette

decreases expression

ISO

bufotalin results in decreased expression of NEBL mRNA

NCBI chr17:85,022,953...85,374,848
Ensembl chr17:85,022,963...85,374,172

G

NEDD8 ubiquitin like modifier

increases expression

ISO

bufotalin results in increased expression of NEDD8 mRNA

NCBI chr15:33,123,505...33,135,522
Ensembl chr15:33,123,505...33,135,522

G

neuraminidase 1

increases expression

ISO

bufotalin results in increased expression of NEU1 mRNA

NCBI chr20:3,902,120...3,906,383
Ensembl chr20:3,902,120...3,906,383

G

neuronal guanine nucleotide exchange factor

decreases expression

ISO

bufotalin results in decreased expression of NGEF mRNA

NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:95,594,823...95,692,251

G

nitrilase 1

decreases expression

ISO

bufotalin results in decreased expression of NIT1 mRNA

NCBI chr13:86,302,334...86,305,770
Ensembl chr13:86,298,387...86,305,770

G

NLR family member X1

decreases expression

ISO

bufotalin results in decreased expression of NLRX1 mRNA

NCBI chr 8:53,486,866...53,503,498
Ensembl chr 8:53,486,867...53,503,523

G

NME/NM23 family member 7

decreases expression

ISO

bufotalin results in decreased expression of NME7 mRNA

NCBI chr13:79,190,462...79,319,890
Ensembl chr13:79,190,334...79,319,890

G

N-myristoyltransferase 1

increases expression

ISO

bufotalin results in increased expression of NMT1 mRNA

NCBI chr10:88,488,918...88,525,496
Ensembl chr10:88,488,990...88,522,729

G

N-acetylneuraminate pyruvate lyase

decreases expression

ISO

bufotalin results in decreased expression of NPL mRNA

NCBI chr13:68,205,602...68,247,940
Ensembl chr13:68,205,603...68,247,999

G

nuclear receptor subfamily 1, group H, member 3

decreases expression

ISO

bufotalin results in decreased expression of NR1H3 mRNA

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor binding protein 2

decreases expression

ISO

bufotalin results in decreased expression of NRBP2 mRNA

NCBI chr 7:109,679,330...109,685,656
Ensembl chr 7:109,679,330...109,685,588

G

nardilysin convertase

decreases expression

ISO

bufotalin results in decreased expression of NRDC mRNA

NCBI chr 5:128,983,395...129,047,578
Ensembl chr 5:128,984,446...129,050,141

G

neuropilin 2

decreases expression

ISO

bufotalin results in decreased expression of NRP2 mRNA

NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871

G

NSE1 homolog, SMC5-SMC6 complex component

decreases expression

ISO

bufotalin results in decreased expression of NSMCE1 mRNA

NCBI chr 1:189,462,801...189,489,188
Ensembl chr 1:189,462,677...189,491,432

G

nuclear mitotic apparatus protein 1

decreases expression

ISO

bufotalin results in decreased expression of NUMA1 mRNA

NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848

G

nucleoporin 35

increases expression

ISO

bufotalin results in increased expression of NUP35 mRNA

NCBI chr 3:85,965,907...85,991,659
Ensembl chr 3:85,945,080...85,992,027

G

ornithine decarboxylase antizyme 3

increases expression

ISO

bufotalin results in increased expression of OAZ3 mRNA

NCBI chr 2:184,762,242...184,765,176
Ensembl chr 2:184,762,245...184,771,428

G

OIP5 antisense RNA 1

decreases expression

ISO

bufotalin results in decreased expression of OIP5-AS1 mRNA

NCBI chr 3:127,032,122...127,045,658

G

origin recognition complex, subunit 6

increases expression

ISO

bufotalin results in increased expression of ORC6 mRNA

NCBI chr19:37,931,085...37,938,856
Ensembl chr19:37,931,090...37,938,856

G

otogelin

decreases expression

ISO

bufotalin results in decreased expression of OTOG mRNA

NCBI chr 1:105,882,747...105,951,825
Ensembl chr 1:105,882,747...105,951,824

G

oxidoreductase-like domain containing 1

decreases expression

ISO

bufotalin results in decreased expression of OXLD1 mRNA

NCBI chr10:106,227,633...106,229,027
Ensembl chr10:106,226,793...106,229,559

G

prolyl 4-hydroxylase subunit beta

affects expression

ISO

bufotalin affects the expression of P4HB mRNA

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

palladin, cytoskeletal associated protein

decreases expression

ISO

bufotalin results in decreased expression of PALLD mRNA

NCBI chr16:33,238,943...33,632,236
Ensembl chr16:33,238,956...33,632,232

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

bufotalin results in increased cleavage of PARP1 protein
bufotalin promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]

PMID:21259053 PMID:21887462 PMID:22841670 PMID:37836626

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

PATJ, crumbs cell polarity complex component

decreases expression

ISO

bufotalin results in decreased expression of PATJ mRNA

NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:118,177,565...118,480,301

G

phosphodiesterase 10A

decreases expression

ISO

bufotalin results in decreased expression of PDE10A mRNA

NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051

G

platelet derived growth factor subunit B

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of PDGFB mRNA]

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

PDZ domain containing 2

decreases expression

ISO

bufotalin results in decreased expression of PDZD2 mRNA

NCBI chr 2:63,111,650...63,497,520
Ensembl chr 2:63,111,650...63,497,478

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression

ISO

bufotalin results in increased expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

protein-glucosylgalactosylhydroxylysine glucosidase

decreases expression

ISO

bufotalin results in decreased expression of PGGHG mRNA

NCBI chr 1:205,467,179...205,474,185
Ensembl chr 1:205,467,993...205,474,183

G

PHD finger protein 14

increases expression

ISO

bufotalin results in increased expression of PHF14 mRNA

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043

G

phosphatidylinositol glycan anchor biosynthesis, class Z

decreases expression

ISO

bufotalin results in decreased expression of PIGZ mRNA

NCBI chr11:82,336,821...82,357,743
Ensembl chr11:82,336,823...82,340,684

G

polycystin 1 like 2

increases expression

ISO

bufotalin results in increased expression of PKD1L2 mRNA

NCBI chr19:61,958,351...62,045,324
Ensembl chr19:61,958,415...62,044,358

G

protein kinase, membrane associated tyrosine/threonine 1

increases expression

ISO

bufotalin results in increased expression of PKMYT1 mRNA

NCBI chr10:13,252,805...13,263,584
Ensembl chr10:13,252,816...13,264,263

G

protein kinase N3

increases expression

ISO

bufotalin results in increased expression of PKN3 mRNA

NCBI chr 3:33,747,610...33,761,405
Ensembl chr 3:33,747,867...33,761,405

G

pleckstrin homology and RhoGEF domain containing G5

decreases expression

ISO

bufotalin results in decreased expression of PLEKHG5 mRNA

NCBI chr 5:167,860,730...167,904,229
Ensembl chr 5:167,860,794...167,904,229

G

patatin-like phospholipase domain containing 2

increases expression

ISO

bufotalin results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

POU class 5 homeobox 1

increases expression

ISO

bufotalin results in increased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

protein phosphatase with EF-hand domain 1

decreases expression

ISO

bufotalin results in decreased expression of PPEF1 mRNA

NCBI chr X:37,803,204...37,960,378
Ensembl chr X:37,830,055...37,960,375

G

periphilin 1

decreases expression

ISO

bufotalin results in decreased expression of PPHLN1 mRNA

NCBI chr 7:126,418,042...126,509,430
Ensembl chr 7:126,417,555...126,509,430

G

protein phosphatase, Mg2+/Mn2+ dependent, 1B

decreases expression

ISO

bufotalin results in decreased expression of PPM1B mRNA

NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:15,399,562...15,460,756

G

protein phosphatase 1, regulatory subunit 36

decreases expression

ISO

bufotalin results in decreased expression of PPP1R36 mRNA

NCBI chr 6:100,874,397...100,894,764
Ensembl chr 6:100,874,374...100,894,756

G

prominin 2

decreases expression

ISO

bufotalin results in decreased expression of PROM2 mRNA

NCBI chr 3:135,200,944...135,215,130
Ensembl chr 3:135,200,944...135,215,077

G

proline and serine rich 3

decreases expression

ISO

bufotalin results in decreased expression of PROSER3 mRNA

NCBI chr 1:94,920,802...94,934,126
Ensembl chr 1:94,920,817...94,933,296

G

prostaglandin D2 synthase

decreases expression

ISO

bufotalin results in decreased expression of PTGDS mRNA

NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:28,680,044...28,682,978

G

prostaglandin reductase 2

decreases expression

ISO

bufotalin results in decreased expression of PTGR2 mRNA

NCBI chr 6:109,662,469...109,694,232
Ensembl chr 6:109,662,498...109,694,232

G

Pvt1 oncogene

increases expression

ISO

bufotalin results in increased expression of PVT1 mRNA

NCBI chr 7:95,545,916...95,769,306

G

R3H domain and coiled-coil containing 1-like

increases expression

ISO

bufotalin results in increased expression of R3HCC1L mRNA

NCBI chr 1:251,266,438...251,344,495
Ensembl chr 1:251,266,493...251,344,495

G

R3H domain containing 2

decreases expression

ISO

bufotalin results in decreased expression of R3HDM2 mRNA

NCBI chr 7:65,097,685...65,225,863
Ensembl chr 7:65,097,923...65,225,862

G

RAB10, member RAS oncogene family

decreases expression

ISO

bufotalin results in decreased expression of RAB10 mRNA

NCBI chr 6:31,974,858...32,039,554
Ensembl chr 6:31,986,921...32,039,733

G

Rab geranylgeranyltransferase subunit alpha

decreases expression

ISO

bufotalin results in decreased expression of RABGGTA mRNA

NCBI chr15:33,176,268...33,183,320
Ensembl chr15:33,176,099...33,183,271

G

RAB, member of RAS oncogene family-like 3

decreases expression

ISO

bufotalin results in decreased expression of RABL3 mRNA

NCBI chr11:76,658,723...76,687,681
Ensembl chr11:76,658,723...76,687,940

G

ral guanine nucleotide dissociation stimulator

decreases expression

ISO

bufotalin results in decreased expression of RALGDS mRNA

NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:32,237,786...32,278,045

G

ral guanine nucleotide dissociation stimulator like 3

decreases expression

ISO

bufotalin results in decreased expression of RGL3 mRNA

NCBI chr 8:28,775,187...28,796,765
Ensembl chr 8:28,776,909...28,796,771

G

RANBP2-type and C3HC4-type zinc finger containing 1

decreases expression

ISO

bufotalin results in decreased expression of RBCK1 mRNA

NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:161,249,390...161,266,032

G

radixin

decreases expression

ISO

bufotalin results in decreased expression of RDX mRNA

NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:61,274,460...61,333,967

G

required for excision 1-B domain containing

decreases expression

ISO

bufotalin results in decreased expression of REX1BD mRNA

NCBI chr16:18,956,023...18,958,494
Ensembl chr16:18,955,969...18,958,494

G

RNA exonuclease 1 homolog

increases expression

ISO

bufotalin results in increased expression of REXO1 mRNA

NCBI chr 7:9,804,740...9,824,717
Ensembl chr 7:9,804,754...9,824,712

G

REX4 homolog, 3'-5' exonuclease

increases expression

ISO

bufotalin results in increased expression of REXO4 mRNA

NCBI chr 3:30,678,729...30,692,376
Ensembl chr 3:30,678,740...30,689,059

G

RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

decreases expression

ISO

bufotalin results in decreased expression of RFNG mRNA

NCBI chr10:106,545,543...106,548,644
Ensembl chr10:106,545,543...106,548,644

G

regulator of G-protein signaling 11

decreases expression

ISO

bufotalin results in decreased expression of RGS11 mRNA

NCBI chr10:15,727,279...15,735,536
Ensembl chr10:15,727,279...15,735,536

G

regulator of G-protein signaling 5

increases expression

ISO

bufotalin results in increased expression of RGS5 mRNA

NCBI chr13:84,381,077...84,417,875
Ensembl chr13:84,380,910...84,421,352

G

rhophilin, Rho GTPase binding protein 1

decreases expression

ISO

bufotalin results in decreased expression of RHPN1 mRNA

NCBI chr 7:109,272,676...109,283,444
Ensembl chr 7:109,272,715...109,283,444

G

ring finger protein 212

decreases expression

ISO

bufotalin results in decreased expression of RNF212 mRNA

NCBI chr14:1,090,752...1,132,242
Ensembl chr14:1,093,759...1,169,966

G

roundabout guidance receptor 3

decreases expression

ISO

bufotalin results in decreased expression of ROBO3 mRNA

NCBI chr 8:45,322,323...45,340,466
Ensembl chr 8:45,323,344...45,340,222

G

RAR-related orphan receptor C

decreases expression

ISO

bufotalin results in decreased expression of RORC mRNA

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

G

RT1 class I, locus CE5

decreases expression

ISO

bufotalin results in decreased expression of HLA-F mRNA

NCBI chr20:3,407,880...3,484,130

G

RWD domain containing 3

decreases expression

ISO

bufotalin results in decreased expression of RWDD3 mRNA

NCBI chr 2:211,918,361...211,933,644
Ensembl chr 2:211,918,361...211,933,592

G

scaffold attachment factor B

increases expression

ISO

bufotalin results in increased expression of SAFB mRNA

NCBI chr 9:1,504,657...1,525,545
Ensembl chr 9:1,504,456...1,525,781

G

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

decreases expression

ISO

bufotalin results in decreased expression of SAMHD1 mRNA

NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:166,181,588...166,214,410

G

secretory carrier membrane protein 3

increases expression

ISO

bufotalin results in increased expression of SCAMP3 mRNA

NCBI chr 2:176,880,873...176,886,750
Ensembl chr 2:176,880,909...176,886,748

G

short coiled-coil protein

increases expression

ISO

bufotalin results in increased expression of SCOC mRNA

NCBI chr19:41,564,166...41,593,932
Ensembl chr19:41,564,112...41,597,912

G

succinate dehydrogenase complex flavoprotein subunit A

increases expression

ISO

bufotalin results in increased expression of SDHA mRNA

NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121

G

SECIS binding protein 2

affects expression

ISO

bufotalin affects the expression of SECISBP2 mRNA

NCBI chr17:13,690,263...13,721,303
Ensembl chr17:13,690,264...13,721,250

G

selenium binding protein 1

decreases expression

ISO

bufotalin results in decreased expression of SELENBP1 mRNA

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:185,183,004...185,194,295

G

selenoprotein M

decreases expression

ISO

bufotalin results in decreased expression of SELENOM mRNA

NCBI chr14:82,619,453...82,622,056
Ensembl chr14:82,619,436...82,622,054

G

Set nuclear proto-oncogene

decreases expression

ISO

bufotalin results in decreased expression of SET mRNA

NCBI chr 3:33,732,319...33,743,433

G

SET domain containing 5

decreases expression

ISO

bufotalin results in decreased expression of SETD5 mRNA

NCBI chr 4:147,772,955...147,850,669
Ensembl chr 4:147,773,028...147,850,667

G

SH2 domain containing 2A

decreases expression

ISO

bufotalin results in decreased expression of SH2D2A mRNA

NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:175,609,874...175,616,685

G

SH2 domain containing 5

increases expression

ISO

bufotalin results in increased expression of SH2D5 mRNA

NCBI chr 5:155,753,087...155,763,936
Ensembl chr 5:155,750,803...155,763,936

G

SH3 domain binding glutamate rich protein like

decreases expression

ISO

bufotalin results in decreased expression of SH3BGRL mRNA

NCBI chr X:78,242,704...78,343,633
Ensembl chr X:78,242,405...78,343,634

G

SH3 domain and tetratricopeptide repeats 1

increases expression

ISO

bufotalin results in increased expression of SH3TC1 mRNA

NCBI chr14:79,230,322...79,274,622
Ensembl chr14:79,230,371...79,274,620

G

signal-induced proliferation-associated 1 like 1

decreases expression

ISO

bufotalin results in decreased expression of SIPA1L1 mRNA

NCBI chr 6:107,570,569...107,849,613
Ensembl chr 6:107,737,392...107,848,160

G

SLAM family member 7

increases expression

ISO

bufotalin results in increased expression of SLAMF7 mRNA

NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341

G

solute carrier family 1 member 7

decreases expression

ISO

bufotalin results in decreased expression of SLC1A7 mRNA

NCBI chr 5:127,959,769...128,003,899
Ensembl chr 5:127,959,769...128,003,899

G

solute carrier family 37 member 4

decreases expression

ISO

bufotalin results in decreased expression of SLC37A4 mRNA

NCBI chr 8:53,619,952...53,626,110
Ensembl chr 8:53,620,141...53,626,110

G

solute carrier family 38, member 2

increases expression

ISO

bufotalin results in increased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 1

increases expression

ISO

bufotalin results in increased expression of SLC39A1 mRNA

NCBI chr 2:178,001,052...178,006,689
Ensembl chr 2:178,001,119...178,006,689

G

solute carrier family 39, member 11

decreases expression

ISO

bufotalin results in decreased expression of SLC39A11 mRNA

NCBI chr10:98,775,155...99,196,302
Ensembl chr10:98,776,525...99,107,368

G

solute carrier family 48 member 1

decreases expression

ISO

bufotalin results in decreased expression of SLC48A1 mRNA

NCBI chr 7:130,794,233...130,802,119
Ensembl chr 7:130,794,245...130,803,022

G

solute carrier organic anion transporter family, member 2a1

decreases expression

ISO

bufotalin results in decreased expression of SLCO2A1 mRNA

NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921

G

solute carrier organic anion transporter family, member 3a1

decreases expression

ISO

bufotalin results in decreased expression of SLCO3A1 mRNA

NCBI chr 1:137,516,037...137,797,836
Ensembl chr 1:137,505,158...137,797,836

G

SLX4 structure-specific endonuclease subunit

decreases expression

ISO

bufotalin results in decreased expression of SLX4 mRNA

NCBI chr10:12,032,131...12,055,685
Ensembl chr10:12,033,048...12,055,650

G

smoothelin

increases expression

ISO

bufotalin results in increased expression of SMTN mRNA

NCBI chr14:82,622,223...82,644,525
Ensembl chr14:82,621,375...82,644,514

G

SET and MYND domain containing 3

decreases expression

ISO

bufotalin results in decreased expression of SMYD3 mRNA

NCBI chr13:93,241,274...93,798,221
Ensembl chr13:93,241,279...93,798,237

G

snail family transcriptional repressor 1

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]

NCBI chr 3:176,667,476...176,671,965

G

synuclein, gamma

decreases expression

ISO

bufotalin results in decreased expression of SNCG mRNA

NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,706,753...9,712,076

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

decreases expression

ISO

bufotalin results in decreased expression of SPOCK2 mRNA

NCBI chr20:28,580,262...28,607,198
Ensembl chr20:28,580,226...28,608,409

G

signal transducer and activator of transcription 1

multiple interactions

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased phosphorylation of STAT1 protein

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 2

decreases expression

ISO

bufotalin results in decreased expression of STAT2 mRNA

NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:1,287,024...1,303,459

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased phosphorylation of STAT3 protein
bufotalin results in decreased phosphorylation of STAT3 protein

PMID:21887462 PMID:37836626

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

STN1 subunit of CST complex

decreases expression

ISO

bufotalin results in decreased expression of STN1 mRNA

NCBI chr 1:256,336,916...256,371,143
Ensembl chr 1:256,315,367...256,370,736

G

SUB1 regulator of transcription

increases expression

ISO

bufotalin results in increased expression of SUB1 mRNA

NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:62,732,736...62,747,679

G

Sad1 and UNC84 domain containing 2

increases expression

ISO

bufotalin results in increased expression of SUN2 mRNA

NCBI chr 7:113,155,766...113,172,950
Ensembl chr 7:113,155,766...113,172,940

G

spectrin repeat containing nuclear envelope protein 1

increases expression

ISO

bufotalin results in increased expression of SYNE1 mRNA

NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721

G

synergin, gamma

increases expression

ISO

bufotalin results in increased expression of SYNRG mRNA

NCBI chr10:69,346,154...69,428,714
Ensembl chr10:69,322,114...69,428,714

G

transport and golgi organization 2 homolog

decreases expression

ISO

bufotalin results in decreased expression of TANGO2 mRNA

NCBI chr11:96,150,292...96,196,883
Ensembl chr11:96,150,266...96,196,881

G

TRAF family member-associated NFKB activator

increases expression

ISO

bufotalin results in increased expression of TANK mRNA

NCBI chr 3:66,522,834...66,598,864
Ensembl chr 3:66,537,175...66,598,864

G

TBC1 domain family, member 5

decreases expression

ISO

bufotalin results in decreased expression of TBC1D5 mRNA

NCBI chr 9:3,740,032...4,256,971
Ensembl chr 9:3,750,325...4,253,581

G

tubulin folding cofactor E

decreases expression

ISO

bufotalin results in decreased expression of TBCE mRNA

NCBI chr17:55,983,627...56,031,578
Ensembl chr17:55,985,707...56,032,302

G

testis associated actin remodelling kinase 1

increases expression

ISO

bufotalin results in increased expression of TESK1 mRNA

NCBI chr 5:62,487,763...62,493,492
Ensembl chr 5:62,487,763...62,493,492

G

transforming growth factor, beta 1

multiple interactions

ISO

bufotalin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
bufotalin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of CTNNB1 protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of CCND1 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of IL10 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of MYC mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of PDGFB mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of WNT10B mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of WNT3 mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased expression of WNT5B mRNA]; bufotalin inhibits the reaction [TGFB1 protein results in increased phosphorylation of GSK3B protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

THO complex subunit 7

decreases expression

ISO

bufotalin results in decreased expression of THOC7 mRNA

NCBI chr15:13,692,855...13,707,692
Ensembl chr15:13,693,396...13,707,704

G

thrombospondin type 1 domain containing 8

decreases expression

ISO

bufotalin results in decreased expression of THSD8 mRNA

G

triokinase and FMN cyclase

decreases expression

ISO

bufotalin results in decreased expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:216,661,477...216,677,928

G

transmembrane protein 150A

decreases expression

ISO

bufotalin results in decreased expression of TMEM150A mRNA

NCBI chr 4:105,968,526...105,972,822
Ensembl chr 4:105,968,702...105,972,822

G

transmembrane protein 167A

increases expression

ISO

bufotalin results in increased expression of TMEM167A mRNA

NCBI chr 2:22,933,027...22,951,974
Ensembl chr Y:3,291,213...3,291,891
Ensembl chr 2:3,291,213...3,291,891

G

transmembrane protein 175

decreases expression

ISO

bufotalin results in decreased expression of TMEM175 mRNA

NCBI chr14:1,217,911...1,234,236
Ensembl chr14:1,217,914...1,234,018

G

transmembrane protein 266

decreases expression

ISO

bufotalin results in decreased expression of TMEM266 mRNA

NCBI chr 8:64,603,199...64,716,770
Ensembl chr 8:64,603,186...64,716,769

G

transmembrane protein 39b

decreases expression

ISO

bufotalin results in decreased expression of TMEM39B mRNA

NCBI chr 5:147,308,616...147,330,895
Ensembl chr 5:147,308,621...147,336,496

G

tumor necrosis factor

increases response to substance
multiple interactions
decreases secretion

ISO

bufotalin results in increased susceptibility to TNF protein
bufotalin affects the reaction [TNF protein affects the expression of BID protein]; bufotalin promotes the reaction [TNF protein results in increased cleavage of CASP3 protein]; bufotalin promotes the reaction [TNF protein results in increased cleavage of CASP8 protein]; bufotalin promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]
bufotalin results in decreased secretion of TNF protein

PMID:21887462 PMID:31950221

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 14

increases expression

ISO

bufotalin results in increased expression of TNFRSF14 mRNA

NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:170,768,416...170,776,046

G

TNF superfamily member 10

increases response to substance
multiple interactions

ISO

bufotalin results in increased susceptibility to TNFSF10 protein
[bufotalin co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; [bufotalin co-treated with TNFSF10 protein] results in decreased expression of BCL2L10 protein; [bufotalin co-treated with TNFSF10 protein] results in decreased expression of BID protein; [bufotalin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein; [bufotalin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [bufotalin co-treated with TNFSF10 protein] results in decreased phosphorylation of STAT1 protein; [bufotalin co-treated with TNFSF10 protein] results in decreased phosphorylation of STAT3 protein; [bufotalin co-treated with TNFSF10 protein] results in increased expression of TNFRSF10B protein; [chan su results in increased abundance of bufotalin] which results in increased susceptibility to TNFSF10 protein; bufotalin affects the reaction [TNFSF10 protein affects the expression of BID protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP7 protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; bufotalin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [bufotalin results in increased expression of TNFRSF10B mRNA]

PMID:21259053 PMID:21887462

NCBI chr 2:112,136,550...112,155,903

G

tumor protein p53

increases expression

ISO

bufotalin results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p73

increases expression

ISO

bufotalin results in increased expression of TP73 mRNA

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

tropomyosin 1

decreases expression

ISO

bufotalin results in decreased expression of TPM1 mRNA

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468

G

tropomyosin 4

decreases expression

ISO

bufotalin results in decreased expression of TPM4 mRNA

NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,717,230...17,732,494

G

Tnf receptor associated factor 4

decreases expression

ISO

bufotalin results in decreased expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,552,253...63,558,356

G

TNF receptor-associated protein 1

increases expression

ISO

bufotalin results in increased expression of TRAP1 mRNA

NCBI chr10:11,971,259...12,005,306
Ensembl chr10:11,970,995...12,005,355

G

tripartite motif-containing 28

increases expression

ISO

bufotalin results in increased expression of TRIM28 mRNA

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tRNA isopentenyltransferase 1

increases expression

ISO

bufotalin results in increased expression of TRIT1 mRNA

NCBI chr 5:140,578,459...140,623,881
Ensembl chr 5:140,580,453...140,623,881

G

tRNA methyltransferase 9B (putative)

decreases expression

ISO

bufotalin results in decreased expression of TRMT9B mRNA

NCBI chr16:62,439,625...62,495,526
Ensembl chr16:62,446,393...62,495,518

G

transient receptor potential cation channel, subfamily M, member 4

decreases expression

ISO

bufotalin results in decreased expression of TRPM4 mRNA

NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:104,918,462...104,948,653

G

tetraspanin 17

decreases expression

ISO

bufotalin results in decreased expression of TSPAN17 mRNA

NCBI chr17:9,824,353...9,831,985
Ensembl chr17:9,823,990...9,831,974

G

tetratricopeptide repeat domain 7A

increases expression

ISO

bufotalin results in increased expression of TTC7A mRNA

NCBI chr 6:12,912,822...13,015,374
Ensembl chr 6:12,905,527...13,015,374

G

tubulin tyrosine ligase like 5

increases expression

ISO

bufotalin results in increased expression of TTLL5 mRNA

NCBI chr 6:111,214,048...111,431,892
Ensembl chr 6:111,214,103...111,431,891

G

thymidylate synthetase

decreases expression

ISO

bufotalin results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

trypsin like peroxisomal matrix peptidase 1

decreases expression

ISO

bufotalin results in decreased expression of TYSND1 mRNA

NCBI chr20:30,180,878...30,188,239
Ensembl chr20:30,181,090...30,188,236

G

ubiquitin conjugating enzyme E2 V2

increases expression

ISO

bufotalin results in increased expression of UBE2V2 mRNA

NCBI chr11:98,808,681...98,842,583
Ensembl chr11:98,807,538...98,843,211

G

UBX domain protein 1

increases expression

ISO

bufotalin results in increased expression of UBXN1 mRNA

NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:215,174,216...215,198,343

G

uncoupling protein 2

decreases expression

ISO

bufotalin results in decreased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

ubiquitin specific peptidase 54

increases expression

ISO

bufotalin results in increased expression of USP54 mRNA

NCBI chr15:3,706,013...3,806,935
Ensembl chr15:3,741,311...3,806,932

G

vinculin

increases expression

ISO

bufotalin results in increased expression of VCL mRNA

NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163

G

vimentin

multiple interactions
decreases expression

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
bufotalin results in decreased expression of VIM protein

PMID:37836626 PMID:38158113

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

VPS39 subunit of HOPS complex

decreases expression

ISO

bufotalin results in decreased expression of VPS39 mRNA

NCBI chr 3:127,721,076...127,758,658
Ensembl chr 3:127,721,076...127,758,768

G

VPS53 subunit of GARP complex

increases expression

ISO

bufotalin results in increased expression of VPS53 mRNA

NCBI chr10:61,418,076...61,536,912
Ensembl chr10:61,418,076...61,531,760

G

WD repeat domain 20

increases expression

ISO

bufotalin results in increased expression of WDR20 mRNA

NCBI chr 6:135,572,502...135,642,688
Ensembl chr 6:135,572,893...135,642,688

G

WD repeat domain 44

decreases expression

ISO

bufotalin results in decreased expression of WDR44 mRNA

NCBI chr X:119,286,802...119,392,240
Ensembl chr X:119,287,142...119,392,232

G

Wnt family member 10B

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of WNT10B mRNA]

NCBI chr 7:131,801,046...131,806,850
Ensembl chr 7:131,801,046...131,806,850

G

Wnt family member 2B

increases expression

ISO

bufotalin results in increased expression of WNT2B mRNA

NCBI chr 2:195,142,573...195,156,945
Ensembl chr 2:195,135,176...195,157,144

G

Wnt family member 3

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of WNT3 mRNA]

NCBI chr10:89,180,224...89,224,195
Ensembl chr10:89,216,801...89,224,195

G

Wnt family member 5B

multiple interactions

ISO

bufotalin inhibits the reaction [TGFB1 protein results in increased expression of WNT5B mRNA]

NCBI chr 4:154,281,852...154,406,081
Ensembl chr 4:154,281,852...154,405,681

G

X-linked inhibitor of apoptosis

multiple interactions

ISO

[bufotalin co-treated with TNFSF10 protein] results in decreased expression of XIAP protein

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

Yes1 associated transcriptional regulator

increases expression

ISO

bufotalin results in increased expression of YAP1 mRNA

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437

G

zinc finger and BTB domain containing 20

decreases expression

ISO

bufotalin results in decreased expression of ZBTB20 mRNA

NCBI chr11:70,558,010...71,297,039
Ensembl chr11:70,580,930...70,736,237

G

zinc finger E-box binding homeobox 1

decreases expression

ISO

bufotalin results in decreased expression of ZEB1 mRNA

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger protein 518A

increases expression

ISO

bufotalin results in increased expression of ZNF518A mRNA

NCBI chr 1:249,668,815...249,694,401
Ensembl chr 1:249,657,809...249,695,569

G

zinc finger protein 598

increases expression

ISO

bufotalin results in increased expression of ZNF598 mRNA

NCBI chr10:14,198,763...14,210,773
Ensembl chr10:14,185,611...14,210,772

G

zinc finger protein 90

decreases expression

ISO

bufotalin results in decreased expression of ZFP90 mRNA

NCBI chr19:51,231,748...51,243,039
Ensembl chr19:51,231,794...51,243,038

G

zinc finger MYM-type containing 1

increases expression

ISO

bufotalin results in increased expression of ZMYM1 mRNA

NCBI chr 5:144,649,238...144,666,334
Ensembl chr 5:144,649,238...144,666,323

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

Cardenolides inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

annexin A1

increases expression

ISO

cinobufagin results in increased expression of ANXA1 mRNA

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

cinobufagin results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

cinobufagin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

basic helix-loop-helix family, member e40

increases expression

ISO

cinobufagin results in increased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

cinobufagin results in decreased expression of BIRC2 protein

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

cinobufagin results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

cyclin A2

decreases expression

ISO

cinobufagin results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

chaperonin containing TCP1 subunit 3

decreases expression

ISO

cinobufagin results in decreased expression of CCT3 mRNA

NCBI chr 2:176,063,529...176,088,180
Ensembl chr 2:176,063,526...176,089,925

G

cyclin dependent kinase 2

decreases expression
multiple interactions

ISO

cinobufagin results in decreased expression of CDK2 mRNA; cinobufagin results in decreased expression of CDK2 protein
cinobufagin results in decreased expression of and results in decreased phosphorylation of CDK2 protein

PMID:21215801 PMID:34619160

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 9

increases expression

ISO

cinobufagin results in increased expression of CDK9 mRNA

NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:36,394,169...36,399,528

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ISO

cinobufagin results in decreased expression of CDKN1A mRNA; cinobufagin results in decreased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases metabolic processing
multiple interactions

ISO

cinobufagin results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased metabolism of cinobufagin
cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; cinobufagin results in increased expression of and results in increased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

dCTP pyrophosphatase 1

decreases expression

ISO

cinobufagin results in decreased expression of DCTPP1 mRNA

NCBI chr 1:191,307,933...191,311,326
Ensembl chr 1:191,307,935...191,313,405

G

epidermal growth factor receptor

decreases expression

ISO

cinobufagin results in decreased expression of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

cinobufagin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutamate-rich WD repeat containing 1

decreases expression

ISO

cinobufagin results in decreased expression of GRWD1 mRNA

NCBI chr 1:105,437,708...105,443,410
Ensembl chr 1:105,437,709...105,443,825

G

glycogen synthase kinase 3 beta

increases expression
multiple interactions
affects response to substance

ISO

cinobufagin results in increased expression of GSK3B protein modified form
GSK3B protein mutant form inhibits the reaction [cinobufagin results in decreased expression of RELA protein]; GSK3B protein mutant form inhibits the reaction [cinobufagin results in increased expression of PARP1 protein modified form]; SB 216763 inhibits the reaction [cinobufagin results in increased expression of GSK3B protein modified form]
GSK3B protein affects the susceptibility to cinobufagin

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

H2A.X variant histone

increases expression

ISO

cinobufagin results in increased expression of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

heat shock protein 90 alpha family class B member 1

decreases expression

ISO

cinobufagin results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

cinobufagin results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

cinobufagin results in increased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

KLF transcription factor 10

increases expression

ISO

cinobufagin results in increased expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ISO

cinobufagin results in decreased expression of MYC mRNA; cinobufagin results in decreased expression of MYC protein

PMID:21215801 PMID:35447139

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

ornithine decarboxylase 1

decreases expression

ISO

cinobufagin results in decreased expression of ODC1 mRNA

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

poly (ADP-ribose) polymerase 1

increases expression
multiple interactions

ISO

cinobufagin results in increased expression of PARP1 protein modified form
GSK3B protein mutant form inhibits the reaction [cinobufagin results in increased expression of PARP1 protein modified form]; SB 216763 promotes the reaction [cinobufagin results in increased expression of PARP1 protein modified form]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

decreases expression

ISO

cinobufagin results in decreased expression of PCNA mRNA; cinobufagin results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions

ISO

cinobufagin results in decreased expression of RELA protein
GSK3B protein mutant form inhibits the reaction [cinobufagin results in decreased expression of RELA protein]; SB 216763 promotes the reaction [cinobufagin results in decreased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ribosomal protein L6

decreases expression

ISO

cinobufagin results in decreased expression of RPL6 mRNA

NCBI chr12:41,008,142...41,012,756
Ensembl chr12:41,008,142...41,025,733

G

ribosomal RNA processing 9, U3 small nucleolar RNA binding protein

decreases expression

ISO

cinobufagin results in decreased expression of RRP9 mRNA

NCBI chr 8:115,995,119...116,004,832
Ensembl chr 8:115,996,169...116,004,824

G

RUNX family transcription factor 1

increases expression

ISO

cinobufagin results in increased expression of RUNX1 mRNA

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

spermidine/spermine N1-acetyl transferase 1

increases expression

ISO

cinobufagin results in increased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

transcription factor B2, mitochondrial

decreases expression

ISO

cinobufagin results in decreased expression of TFB2M mRNA

NCBI chr13:93,810,859...93,828,678
Ensembl chr13:93,810,731...93,828,594

G

transforming growth factor, beta 1

increases expression

ISO

cinobufagin results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta receptor 1

increases expression

ISO

cinobufagin results in increased expression of TGFBR1 mRNA

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

TIMP metallopeptidase inhibitor 2

increases expression

ISO

cinobufagin results in increased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

tumor necrosis factor

increases expression

ISO

cinobufagin results in increased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin interacting protein

increases expression

ISO

cinobufagin results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thymidylate synthetase

multiple interactions
decreases expression

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cinobufagin results in decreased expression of TYMS protein]; cinobufagin promotes the reaction [Cycloheximide results in decreased expression of TYMS protein]

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

X-linked inhibitor of apoptosis

decreases expression

ISO

cinobufagin results in decreased expression of XIAP protein

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

ISO

cinobufotalin results in decreased phosphorylation of AKT1 protein
MIR2110 affects the reaction [cinobufotalin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

increases activity

ISO

cinobufotalin results in increased activity of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BH3 interacting domain death agonist

increases activity

ISO

cinobufotalin results in increased activity of BID protein

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

caspase 2

increases cleavage

ISO

cinobufotalin results in increased cleavage of CASP2 protein

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases cleavage

ISO

cinobufotalin results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases cleavage

ISO

cinobufotalin results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage

ISO

cinobufotalin results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

Fas cell surface death receptor

increases expression

ISO

cinobufotalin results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

cinobufotalin results in decreased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

thymidylate synthetase

decreases expression

ISO

cinobufotalin results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

Cymarine inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases transport

ISO

Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin

PMID:23104431 PMID:26708294

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

androgen receptor

multiple interactions

ISO

Digitoxin binds to and results in decreased activity of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

caspase 3

decreases expression
multiple interactions

ISO

Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]

PMID:22037315 PMID:34717917

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases cleavage
multiple interactions

ISO

Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]

PMID:22037315 PMID:34717917

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage

ISO

Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

C-C motif chemokine ligand 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin B1

multiple interactions
decreases expression

ISO

Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression

ISO

Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]
Digitoxin results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase 1

decreases expression
multiple interactions

ISO

Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ISO

Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases expression

ISO

Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

checkpoint kinase 1

decreases expression

ISO

Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

decreases expression

ISO

Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

cytochrome c, somatic

increases expression

ISO

Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases phosphorylation

ISO

Digitoxin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF4EBP1 protein]
Digitoxin results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

estrogen receptor 1

multiple interactions

ISO

Digitoxin binds to and results in decreased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions

ISO

Digitoxin binds to and results in decreased activity of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

FA complementation group D2

multiple interactions

ISO

Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

FA complementation group I

multiple interactions

ISO

Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:142,736,653...142,792,999

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Digitoxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

interleukin 1 beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

mitogen activated protein kinase 1

multiple interactions

ISO

Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

decreases phosphorylation

ISO

Digitoxin results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 3

multiple interactions
increases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

progesterone receptor

multiple interactions

ISO

Digitoxin binds to and results in decreased activity of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

protein inhibitor of activated STAT, 3

increases expression

ISO

Digitoxin results in increased expression of PIAS3 protein

NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:186,921,428...186,936,714

G

phosphatase and tensin homolog

increases expression

ISO

Digitoxin results in increased expression of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

ISO

Digitoxin results in increased expression of PTPN6 protein

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

ISO

Digitoxin results in decreased phosphorylation of RPS6KB1 protein
[Digitoxin co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

signal transducer and activator of transcription 3

multiple interactions

ISO

[Digitoxin co-treated with Oxygen deficiency] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; Digitoxin results in decreased expression of and results in decreased phosphorylation of STAT3 protein; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

thyroid hormone receptor alpha

multiple interactions

ISO

Digitoxin binds to and results in decreased activity of THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor beta

multiple interactions

ISO

Digitoxin binds to and results in decreased activity of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

tumor protein p53

decreases expression

ISO

Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

vascular cell adhesion molecule 1

multiple interactions

ISO

Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 8

multiple interactions

ISO

Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr10:95,416,984...95,490,647
Ensembl chr10:95,416,205...95,490,452

G

ATP binding cassette subfamily B member 1A

affects abundance
affects uptake
increases uptake
multiple interactions
increases export
increases transport
affects secretion
increases expression
affects binding
decreases uptake
affects transport

ISO
EXP

ABCB1 gene SNP affects the abundance of Digoxin
ABCB1A protein affects the uptake of Digoxin
ABCB1 protein results in increased uptake of Digoxin
18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Plant Extracts results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; ABCB1 protein binds to and affects the metabolism of Digoxin; abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; cyazofamid affects the reaction [ABCB1 protein results in increased uptake of Digoxin]; dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]; gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Digoxin; Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin]
ABCB1A protein results in increased uptake of Digoxin
ABCB1 protein affects the secretion of Digoxin
Digoxin results in increased expression of ABCB1 mRNA; Digoxin results in increased expression of ABCB1 protein
Digoxin binds to ABCB1 protein
ABCB1 protein results in decreased uptake of Digoxin
ABCB1 gene SNP affects the transport of Digoxin; ABCB1 protein affects the transport of Digoxin

PMID:10527640 PMID:10562306 PMID:10617675 PMID:10997946 PMID:11231118 More...

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

affects uptake

ISO

ABCB1B protein affects the uptake of Digoxin

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily G member 2

decreases activity

ISO

Digoxin results in decreased activity of ABCG2 protein

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression
multiple interactions

EXP

Digoxin results in decreased expression of ATP1A2 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression
multiple interactions

EXP

Digoxin results in decreased expression of ATP1A3 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A3 mRNA]

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825

G

C-C motif chemokine ligand 2

decreases expression

ISO

Digoxin results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 4

decreases expression

ISO

Digoxin results in decreased expression of CCL4 protein

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

decreases expression

ISO

Digoxin results in decreased expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 protein]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 9

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 protein]

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

C-X-C motif chemokine receptor 3

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein]

NCBI chr X:70,884,293...70,886,944
Ensembl chr X:70,883,958...70,886,871

G

early growth response 1

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 protein]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

FA complementation group D2

multiple interactions

ISO

Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

FA complementation group I

multiple interactions

ISO

Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:142,736,653...142,792,999

G

glucose-6-phosphate dehydrogenase

decreases activity

EXP

Digoxin results in decreased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glial fibrillary acidic protein

increases expression

EXP

Digoxin results in increased expression of GFAP mRNA

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glutamic-oxaloacetic transaminase 1

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

decreases activity

EXP

Digoxin results in decreased activity of GSR protein

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases activity
affects localization

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein]; Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein; KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]
Digoxin results in increased activity of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

intercellular adhesion molecule 1

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions

ISO

[Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 17A

multiple interactions

ISO

Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]; Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A protein]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 2

multiple interactions

ISO

[Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 23 receptor

multiple interactions

ISO

Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL23R mRNA]

NCBI chr 4:97,910,230...98,003,759
Ensembl chr 4:97,909,972...98,004,110

G

interleukin 6 receptor

decreases expression

ISO

Digoxin results in decreased expression of IL6R protein modified form

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

insulin 2

decreases response to substance

ISO
EXP

INS protein results in decreased susceptibility to Digoxin

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
affects response to substance
decreases expression
decreases activity

ISO

Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]
KCNH2 gene affects the susceptibility to Digoxin
Digoxin results in decreased expression of KCNH2 protein modified form

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

EXP

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

EXP

Digoxin results in increased phosphorylation of MAPK3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

nitric oxide synthase 3

decreases response to substance

ISO

NOS3 protein results in decreased susceptibility to Digoxin

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

natriuretic peptide A

multiple interactions
increases expression

EXP

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

increases expression

ISO

Digoxin results in increased expression of NPPB protein

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

phosphogluconate dehydrogenase

decreases activity

EXP

Digoxin results in decreased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

RAR-related orphan receptor C

decreases activity
multiple interactions

ISO

Digoxin results in decreased activity of RORC protein
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC protein]

PMID:21441909 PMID:36329302

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

G

solute carrier family 22 member 1

multiple interactions

ISO

Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 3

multiple interactions

ISO

Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 9 member A1

increases expression
multiple interactions

EXP

Digoxin results in increased expression of SLC9A1 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA]

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

solute carrier organic anion transporter family, member 1a4

multiple interactions
increases uptake
decreases activity
affects transport

ISO
EXP

Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite]; Elacridar affects the reaction [SLCO1A4 protein affects the transport of Digoxin]
SLCO1A4 protein results in increased uptake of Digoxin
Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
Digoxin results in decreased activity of SLCO1A4 protein

PMID:11883641 PMID:19833843 PMID:34619012

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

Digoxin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1B2 mRNA]

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

TAR DNA binding protein

multiple interactions

ISO

Digoxin inhibits the reaction [TARDBP protein binds to TARDBP protein]

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

vascular endothelial growth factor A

decreases expression

ISO

Digoxin results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

ISO

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
dihydroouabain results in increased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

interleukin 17A

multiple interactions

ISO

dihydroouabain results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17F

multiple interactions

ISO

dihydroouabain results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:30,686,538...30,697,918

G

neuronal PAS domain protein 2

increases expression
multiple interactions

ISO

dihydroouabain results in increased expression of NPAS2 mRNA
dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

RAR-related orphan receptor C

multiple interactions
increases expression

ISO

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

drospirenone results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

androgen receptor

multiple interactions
affects localization

ISO

drospirenone binds to and results in increased activity of AR protein
drospirenone affects the localization of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

ISO

[Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

ISO

drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO

[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

nitric oxide synthase 2

multiple interactions

ISO

[Ethinyl Estradiol co-treated with drospirenone] results in decreased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 3, group C, member 2

affects binding

EXP

drospirenone binds to NR3C2 protein

PMID:1493716 PMID:14667981

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

progesterone receptor

affects binding

ISO

drospirenone binds to PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

serpin family A member 6

multiple interactions

ISO

[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SERPINA6 protein

NCBI chr 6:128,544,828...128,555,064
Ensembl chr 6:128,544,831...128,555,139

G

sex hormone binding globulin

multiple interactions

ISO

[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

ATM serine/threonine kinase

increases phosphorylation

ISO

hellebrigenin results in increased phosphorylation of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

BCL2 associated X, apoptosis regulator

affects localization

ISO

hellebrigenin affects the localization of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

cyclin B1

increases expression

ISO

hellebrigenin results in increased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cell division cycle 25C

decreases phosphorylation

ISO

hellebrigenin results in decreased phosphorylation of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

increases phosphorylation

ISO

hellebrigenin results in increased phosphorylation of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

checkpoint kinase 2

increases phosphorylation

ISO

hellebrigenin results in increased phosphorylation of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

poly (ADP-ribose) polymerase 1

increases activity

ISO

hellebrigenin results in increased activity of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RAR-related orphan receptor C

increases expression

ISO

helveticoside results in increased expression of RORC mRNA

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

decreases expression

ISO

lanatoside C results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 4

decreases expression

ISO

lanatoside C results in decreased expression of CCL4 protein

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

decreases expression

ISO

lanatoside C results in decreased expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

interleukin 6 receptor

decreases expression

ISO

lanatoside C results in decreased expression of IL6R protein modified form

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

TAR DNA binding protein

multiple interactions

ISO

lanatoside C inhibits the reaction [TARDBP protein binds to TARDBP protein]

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

vascular endothelial growth factor A

decreases expression

ISO

lanatoside C results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

ISO

oleandrin results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity

ISO

oleandrin results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

C-X-C motif chemokine receptor 1

increases expression

ISO

oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872

G

C-X-C motif chemokine receptor 2

increases expression

ISO

oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein

NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602

G

C-X-C motif chemokine receptor 4

increases expression

ISO

oleandrin results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

affects expression

ISO

Ouabain affects the expression of A2M protein

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acetyl-CoA acyltransferase 2

affects expression

ISO

Ouabain affects the expression of ACAA2 protein

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

angiotensin I converting enzyme

affects expression

EXP

Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

actin alpha 2, smooth muscle

affects expression

ISO

Ouabain affects the expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

ISO

Ouabain affects the expression of ADH1C protein

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

angiotensinogen

affects expression
increases expression

EXP

Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein

PMID:11768735 PMID:16565308

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

decreases expression
affects expression

EXP

Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Ouabain results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

annexin A1

affects expression

ISO

Ouabain affects the expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A2

affects expression

ISO

Ouabain affects the expression of ANXA2 protein

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

apoptotic peptidase activating factor 1

increases expression

ISO

Ouabain results in increased expression of APAF1 protein

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

ISO

Ouabain results in decreased expression of ARAF mRNA

NCBI chr X:3,780,932...3,845,919
Ensembl chr X:3,780,932...3,792,611

G

ariadne RBR E3 ubiquitin protein ligase 1

decreases expression

ISO

Ouabain results in decreased expression of ARIH1 mRNA

NCBI chr 8:68,673,199...68,775,648
Ensembl chr 8:68,673,200...68,775,572

G

actin related protein 2/3 complex, subunit 5

affects expression

ISO

Ouabain affects the expression of ARPC5 protein

NCBI chr13:67,454,379...67,463,288
Ensembl chr13:67,437,027...67,463,283

G

arrestin, beta 1

increases expression

ISO

Ouabain results in increased expression of ARRB1 mRNA

NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859

G

N-acylsphingosine amidohydrolase 1

affects expression

ISO

Ouabain affects the expression of ASAH1 protein

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

activating transcription factor 6 beta

increases expression

ISO

Ouabain results in increased expression of ATF6B protein

NCBI chr20:4,095,534...4,103,534
Ensembl chr20:4,095,534...4,106,032

G

ATM serine/threonine kinase

increases phosphorylation

ISO

Ouabain results in increased phosphorylation of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase H+/K+ transporting non-gastric alpha2 subunit

multiple interactions

ISO
EXP

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]
Ouabain results in decreased activity of [ATP12A protein binds to ATP1B1 protein]

PMID:8853415 PMID:16046397

NCBI chr15:34,559,209...34,583,866
Ensembl chr15:34,559,209...34,583,866

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression
affects expression
affects binding

ISO
EXP

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein

PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding

ISO
EXP

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein

PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More...

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
multiple interactions
decreases expression
affects expression
affects binding

ISO
EXP

Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein

PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More...

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions
increases expression

EXP

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Ouabain results in decreased activity of [ATP12A protein binds to ATP1B1 protein]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]

PMID:11204457 PMID:16046397

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATPase H+/K+ transporting subunit beta

multiple interactions

ISO

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr16:82,846,329...82,855,242
Ensembl chr16:82,846,329...82,855,242

G

ATP synthase F1 subunit alpha

affects expression

ISO

Ouabain affects the expression of ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATR serine/threonine kinase

decreases phosphorylation

ISO

Ouabain results in decreased phosphorylation of ATR protein

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

bromo adjacent homology domain containing 1

decreases expression

ISO

Ouabain results in decreased expression of BAHD1 mRNA

NCBI chr 3:126,341,853...126,368,281
Ensembl chr 3:126,345,371...126,368,278

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

ISO

Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]

PMID:17096883 PMID:18247327 PMID:31436044

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Ouabain results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

Ouabain results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

EXP

Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

BRCA1, DNA repair associated

decreases expression

ISO

Ouabain results in decreased expression of BRCA1 protein

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

calbindin 1

decreases expression

EXP

Ouabain results in decreased expression of CALB1 protein

NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160

G

calmodulin-like 5

affects expression

ISO

Ouabain affects the expression of CALML5 protein

NCBI chr17:71,304,326...71,305,245
Ensembl chr17:71,304,326...71,305,245

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

ISO

Ouabain results in increased expression of CAMK2B protein

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calnexin

increases expression

ISO

Ouabain results in increased expression of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 3

increases expression
multiple interactions
increases activity

ISO
EXP

Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein

PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases expression

ISO

Ouabain results in increased expression of CASP4 protein

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 8

multiple interactions

ISO

Ouabain results in increased expression of and results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

Ouabain results in increased expression of and results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity

EXP

Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

decreases expression

ISO

Ouabain results in decreased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

coiled-coil domain containing 14

decreases expression

ISO

Ouabain results in decreased expression of CCDC14 mRNA

NCBI chr11:79,557,267...79,593,128
Ensembl chr11:79,557,274...79,593,285

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

EXP

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin A1

decreases expression

ISO

Ouabain results in decreased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin A2

decreases expression

ISO

Ouabain results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin D1

decreases expression

ISO

Ouabain results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cadherin 1

decreases expression
increases expression

ISO

Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 2

decreases expression

ISO

Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin dependent kinase 2

decreases expression

ISO

Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein

PMID:20460749 PMID:21215801 PMID:31436044

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 6

decreases expression

ISO

Ouabain results in decreased expression of CDK6 protein

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

decreases expression
increases expression

ISO

Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein

PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

creatine kinase B

decreases activity

EXP

Ouabain results in decreased activity of CKB protein

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

claudin 1

decreases expression

ISO

Ouabain results in decreased expression of CLDN1 protein

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

canopy FGF signaling regulator 2

affects expression

ISO

Ouabain affects the expression of CNPY2 protein

NCBI chr 7:1,332,293...1,338,081
Ensembl chr 7:1,334,335...1,340,333

G

collagen type I alpha 1 chain

multiple interactions
increases expression

EXP

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

citrate synthase

decreases activity

EXP

Ouabain results in decreased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

cytochrome c-1

multiple interactions

ISO

Ouabain results in decreased expression of and affects the localization of CYC1 protein

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657

G

DNA-damage inducible transcript 3

increases expression

ISO

Ouabain results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

decreases expression

ISO

Ouabain results in decreased expression of DDOST mRNA

NCBI chr 5:155,805,612...155,812,728
Ensembl chr 5:155,805,454...155,813,121

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

ISO

Ouabain results in increased expression of DNAJA3 mRNA

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599

G

dopamine receptor D1

multiple interactions
decreases expression

ISO
EXP

Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA

PMID:19626329 PMID:20132239

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

desmoglein 1

affects expression

ISO

Ouabain affects the expression of DSG1 protein

NCBI chr18:11,948,098...11,980,455
Ensembl chr18:11,949,488...11,980,451

G

deoxyuridine triphosphatase

affects expression

ISO

Ouabain affects the expression of DUT protein

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

endothelin converting enzyme 1

increases expression

ISO

Ouabain results in increased expression of ECE1 protein

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

enoyl-CoA hydratase, short chain 1

affects expression

ISO

Ouabain affects the expression of ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

endothelin 1

increases expression
decreases expression

EXP
ISO

Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA

PMID:15477225 PMID:28795476

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

increases expression

EXP

Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein

PMID:15477225 PMID:16982439

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

epidermal growth factor receptor

decreases phosphorylation

ISO

Ouabain results in decreased phosphorylation of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

eukaryotic translation initiation factor 2A

increases expression

ISO

Ouabain results in increased expression of EIF2A protein

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

ISO

Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 3, subunit K

affects expression

ISO

Ouabain affects the expression of EIF3K protein

NCBI chr 1:93,387,628...93,397,551
Ensembl chr 1:93,387,628...93,397,802

G

endonuclease G

increases expression

ISO

Ouabain results in increased expression of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

ERCC excision repair 4, endonuclease catalytic subunit

decreases expression

ISO

Ouabain results in decreased expression of ERCC4 mRNA

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,920,455...2,955,539

G

ETS proto-oncogene 1, transcription factor

decreases expression

ISO

Ouabain results in decreased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

Fas associated via death domain

increases expression

ISO

Ouabain results in increased expression of FADD protein

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

FA complementation group D2

multiple interactions
decreases expression

ISO

Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

FA complementation group F

decreases expression

ISO

Ouabain results in decreased expression of FANCF mRNA

NCBI chr 1:110,585,054...110,587,870
Ensembl chr 1:110,576,389...110,587,863

G

FA complementation group I

decreases expression
multiple interactions

ISO

Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:142,736,653...142,792,999

G

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

ISO

Ouabain results in increased expression of FARS2 mRNA

NCBI chr17:28,524,737...28,951,818
Ensembl chr17:28,524,738...28,951,591

G

Fas cell surface death receptor

increases expression

ISO

Ouabain results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

Ouabain results in increased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box protein 32

multiple interactions

ISO

Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]

NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491

G

fumarate hydratase

affects expression

ISO

Ouabain affects the expression of FH protein

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

FKBP prolyl isomerase 7

increases expression

ISO

Ouabain results in increased expression of FKBP7 mRNA

NCBI chr 3:82,016,647...82,030,913
Ensembl chr 3:82,016,513...82,028,573

G

fibronectin 1

decreases expression

ISO

Ouabain results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

GC, vitamin D binding protein

affects expression

ISO

Ouabain affects the expression of GC protein

NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673

G

glycine receptor, beta

increases expression

ISO

Ouabain results in increased expression of GLRB mRNA

NCBI chr 2:168,432,736...168,505,614
Ensembl chr 2:168,432,736...168,505,614

G

growth factor receptor bound protein 2

decreases expression

ISO

Ouabain results in decreased expression of GRB2 protein

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

glutamate ionotropic receptor NMDA type subunit 1

affects expression

EXP

Ouabain affects the expression of GRIN1 protein

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

EXP

Ouabain results in decreased expression of GRIN2A protein

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

EXP

Ouabain results in decreased expression of GRIN2B protein

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

EXP

Ouabain results in decreased expression of GRIN2C protein

NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression

EXP

Ouabain results in increased expression of GRIN2D protein

NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:105,444,813...105,481,236

G

GTP binding protein 6 (putative)

increases expression

ISO

Ouabain results in increased expression of GTPBP6 mRNA

NCBI chr12:52,234,646...52,238,578
Ensembl chr12:52,234,572...52,238,578

G

H2A.X variant histone

increases phosphorylation

ISO

Ouabain results in increased phosphorylation of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

ISO

Ouabain results in increased expression of HEY1 mRNA

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624

G

hepatocyte growth factor

multiple interactions

EXP

Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
affects localization
increases activity

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heterogeneous nuclear ribonucleoprotein A2/B1

affects expression

ISO

Ouabain affects the expression of HNRNPA2B1 protein

NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572

G

heterogeneous nuclear ribonucleoprotein D-like

decreases expression

ISO

Ouabain results in decreased expression of HNRNPDL mRNA

NCBI chr14:9,861,716...9,867,945
Ensembl chr14:9,861,716...9,867,945

G

hippocalcin-like 1

affects expression

ISO

Ouabain affects the expression of HPCAL1 protein

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

histidine-rich glycoprotein

affects expression

ISO

Ouabain affects the expression of HRG protein

NCBI chr11:91,559,087...91,573,982
Ensembl chr11:91,559,091...91,573,982

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Ouabain results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family D (Hsp60) member 1

affects expression
multiple interactions

ISO

Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein

PMID:17268060 PMID:18247327

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

inhibitor of DNA binding 2

increases expression

ISO

Ouabain results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

interleukin 2 receptor subunit alpha

decreases expression

ISO

Ouabain results in decreased expression of IL2RA mRNA

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 2 receptor subunit beta

decreases expression

ISO

Ouabain results in decreased expression of IL2RB

NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537

G

interleukin 6

increases secretion
increases expression

ISO

Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

increases expression

ISO

Ouabain results in increased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

integrin-linked kinase

decreases expression

ISO

Ouabain results in decreased expression of ILK mRNA

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

integrin subunit alpha V

decreases expression

ISO

Ouabain results in decreased expression of ITGAV mRNA

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
decreases phosphorylation

ISO

Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel subfamily D member 2

increases expression

ISO
EXP

Ouabain results in increased expression of KCND2 mRNA

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium voltage-gated channel subfamily H member 2

decreases expression
decreases activity
multiple interactions

ISO

Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:19139152 PMID:21158687

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

lymphoid enhancer binding factor 1

decreases expression

ISO

Ouabain results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

galectin 1

affects expression
increases expression

ISO

Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein

PMID:17268060 PMID:18247327

NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800

G

LIM domain kinase 1

decreases expression

ISO

Ouabain results in decreased expression of LIMK1 mRNA

NCBI chr12:27,663,177...27,697,085
Ensembl chr12:27,663,018...27,697,209

G

lanosterol synthase

increases abundance

ISO

LSS protein results in increased abundance of Ouabain

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

mitogen-activated protein kinase kinase 6

increases expression

ISO

Ouabain results in increased expression of MAP2K6 mRNA

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein

PMID:19687166 PMID:28795476

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein

PMID:19687166 PMID:28795476

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 7

multiple interactions

ISO

Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein]

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

malate dehydrogenase 2

affects expression

ISO

Ouabain affects the expression of MDH2 protein

NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841

G

MDM2 proto-oncogene

multiple interactions

ISO

Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

O-6-methylguanine-DNA methyltransferase

decreases expression

ISO

Ouabain results in decreased expression of MGMT protein

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microRNA 29b-1

multiple interactions
decreases expression

EXP

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA

NCBI chr 4:60,618,334...60,618,414

G

matrix metallopeptidase 13

decreases expression

ISO

Ouabain results in decreased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

decreases expression
multiple interactions

ISO

Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

decreases expression

ISO

Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein

PMID:28795476 PMID:33760381

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

muscle RAS oncogene homolog

decreases expression

ISO

Ouabain results in decreased expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911

G

myocardin related transcription factor A

decreases expression

ISO

Ouabain results in decreased expression of MRTFA mRNA

NCBI chr 7:114,424,481...114,594,594
Ensembl chr 7:114,424,481...114,594,594

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression

ISO

Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein

PMID:9653513 PMID:21215801

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin light chain 12A

increases expression

ISO

Ouabain results in increased expression of MYL12A protein

NCBI chr 9:118,338,592...118,346,277
Ensembl chr 9:118,338,604...118,342,634

G

myosin light chain kinase

decreases expression

ISO

Ouabain results in decreased expression of MYLK mRNA

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659

G

nectin cell adhesion molecule 3

decreases expression

ISO

Ouabain results in decreased expression of NECTIN3 mRNA

NCBI chr11:67,825,296...67,931,999
Ensembl chr11:67,827,137...67,871,383

G

nectin cell adhesion molecule 4

increases expression

ISO

Ouabain results in increased expression of NECTIN4 mRNA

NCBI chr13:86,335,027...86,354,152
Ensembl chr13:86,335,831...86,353,967

G

neurofilament light chain

decreases expression

ISO

Ouabain results in decreased expression of NEFL mRNA

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

nitric oxide synthase 1

affects expression
increases expression

EXP

Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein

PMID:12384489 PMID:15097235

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 3

multiple interactions
affects expression
increases expression

EXP

5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein

PMID:12384489 PMID:15477225

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NPC intracellular cholesterol transporter 2

decreases expression

ISO

Ouabain results in decreased expression of NPC2 mRNA

NCBI chr 6:110,128,325...110,149,245
Ensembl chr 6:110,128,325...110,150,004

G

natriuretic peptide A

increases expression
multiple interactions

EXP

Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:17266992 PMID:19687166

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

NRAS proto-oncogene, GTPase

decreases expression

ISO

Ouabain results in decreased expression of NRAS mRNA

NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543

G

Parkinsonism associated deglycase

affects response to substance

ISO

PARK7 affects the susceptibility to Ouabain

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein]

PMID:24124520 PMID:31436044

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

decreases expression

ISO

Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein

PMID:20460749 PMID:21215801

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

programmed cell death 6

increases expression

ISO

Ouabain results in increased expression of PDCD6 protein

NCBI chr 1:30,795,105...30,810,771
Ensembl chr 1:30,795,040...30,810,773

G

prefoldin subunit 5

affects expression

ISO

Ouabain affects the expression of PFDN5 protein

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099

G

profilin 1

affects expression
decreases expression

ISO

Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein

PMID:17268060 PMID:18247327

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

plasminogen activator, urokinase receptor

decreases expression

ISO

Ouabain results in decreased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase C, gamma 1

decreases expression

ISO

Ouabain results in decreased expression of PLCG1 mRNA

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

palmitoyl-protein thioesterase 2

decreases expression

ISO

Ouabain results in decreased expression of PPT2 mRNA

NCBI chr20:4,117,088...4,137,382
Ensembl chr20:4,127,164...4,137,381

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

ISO

Ouabain results in decreased expression of PRKDC protein

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

proteasome 20S subunit beta 6

affects expression

ISO

Ouabain affects the expression of PSMB6 protein

NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP

[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 2

decreases expression

ISO

Ouabain results in decreased expression of PTPN2 mRNA

NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481

G

RAB11B, member RAS oncogene family

increases expression

ISO

Ouabain results in increased expression of RAB11B protein

NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

ISO

Ouabain results in decreased expression of RAF1 mRNA

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RAS protein-specific guanine nucleotide-releasing factor 1

decreases expression

ISO

Ouabain results in decreased expression of RASGRF1 mRNA

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

regulator of G-protein signaling 2

decreases expression

ISO

Ouabain results in decreased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

ras homolog family member H

increases expression

ISO

Ouabain results in increased expression of RHOH mRNA

NCBI chr14:42,694,860...42,725,690
Ensembl chr14:42,693,413...42,749,967

G

Rho-associated coiled-coil containing protein kinase 1

increases cleavage
multiple interactions

ISO

Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

multiple interactions
increases cleavage

ISO

benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

replication protein A3

affects expression

ISO

Ouabain affects the expression of RPA3 protein

NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:37,270,966...37,274,183

G

Rpgrip1-like

decreases expression

ISO

Ouabain results in decreased expression of RPGRIP1L mRNA

NCBI chr19:31,865,050...31,957,930
Ensembl chr19:31,865,231...31,957,930

G

ribosomal protein S6 kinase B1

affects expression

EXP

Ouabain affects the expression of RPS6KB1 mRNA

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ryanodine receptor 2

multiple interactions
increases response to substance

ISO

K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705

G

S100 calcium binding protein A13

affects expression

ISO

Ouabain affects the expression of S100A13 protein

NCBI chr 2:178,297,020...178,303,514
Ensembl chr 2:178,296,917...178,303,507

G

S100 calcium binding protein B

increases expression

EXP

Ouabain results in increased expression of S100B protein

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression

ISO

Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA

PMID:12590200 PMID:28795476

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

serum/glucocorticoid regulated kinase 2

multiple interactions

ISO

Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]

NCBI chr 3:172,063,625...172,089,000
Ensembl chr 3:172,063,776...172,089,011

G

serum/glucocorticoid regulated kinase family, member 3

multiple interactions

ISO

Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium]

NCBI chr 5:14,128,628...14,255,099
Ensembl chr 5:14,126,257...14,198,331

G

SHC adaptor protein 3

increases expression

ISO

Ouabain results in increased expression of SHC3 mRNA

NCBI chr17:13,803,980...13,924,433
Ensembl chr17:13,803,781...13,924,433

G

solute carrier family 16 member 1

multiple interactions

ISO

Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 22 member 12

multiple interactions

ISO

Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380

G

solute carrier family 5 member 5

multiple interactions

ISO

Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

solute carrier family 5 member 6

multiple interactions

ISO

Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:31,040,017...31,051,670

G

solute carrier family 8 member A1

affects response to substance
increases expression
multiple interactions

ISO
EXP

SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]

PMID:16166162 PMID:19897708

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964

G

solute carrier family 9 member A1

multiple interactions
increases expression

EXP

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA]

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

SMAD family member 4

decreases expression

ISO

Ouabain results in decreased expression of SMAD4 mRNA

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684

G

snail family transcriptional repressor 1

decreases expression

ISO

Ouabain results in decreased expression of SNAI1 mRNA

NCBI chr 3:176,667,476...176,671,965

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

ISO

Ouabain results in decreased expression of SOS1 protein

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

SOS Ras/Rho guanine nucleotide exchange factor 2

decreases expression

ISO

Ouabain results in decreased expression of SOS2 mRNA

NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811

G

sphingosine kinase 1

decreases expression

ISO

Ouabain results in decreased expression of SPHK1 mRNA

NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082

G

transforming growth factor, beta 1

decreases expression

ISO

Ouabain results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

decreases expression

ISO

Ouabain results in decreased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

decreases expression

ISO

Ouabain results in decreased expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transforming growth factor beta receptor 3

increases expression

ISO

Ouabain results in increased expression of TGFBR3 mRNA

NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,634,188...2,810,271

G

talin 1

decreases expression

ISO

Ouabain results in decreased expression of TLN1 mRNA

NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:62,583,731...62,613,687

G

talin 2

decreases expression

ISO

Ouabain results in decreased expression of TLN2 mRNA

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361

G

TNF receptor superfamily member 10b

increases expression

ISO

Ouabain results in increased expression of TNFRSF10A protein

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

tumor protein p53

multiple interactions

ISO

Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

triosephosphate isomerase 1

affects expression

ISO

Ouabain affects the expression of TPI1 protein

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

tumor protein, translationally-controlled 1

affects expression

ISO

Ouabain affects the expression of TPT1 protein

NCBI chr15:57,562,217...57,568,968
Ensembl chr15:57,566,067...57,569,554

G

tripartite motif containing 63

multiple interactions

ISO

[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA

NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

EXP

Ouabain results in increased expression of TRPC1 protein

NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:105,142,931...105,193,826

G

transient receptor potential cation channel, subfamily C, member 6

increases expression
multiple interactions

EXP

Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304

G

twist family bHLH transcription factor 1

increases expression

ISO

Ouabain results in increased expression of TWIST1 mRNA

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965

G

thioredoxin 1

affects expression

ISO

Ouabain affects the expression of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

vimentin

decreases expression

ISO

Ouabain results in decreased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

zinc finger homeobox 3

decreases expression

ISO

Ouabain results in decreased expression of ZFHX3 mRNA

NCBI chr19:52,789,146...53,795,664
Ensembl chr19:53,551,488...53,795,664

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

cannogenin thevetoside inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
increases metabolic processing

ISO

rutaevin results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of rutaevin

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Spironolactone results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

ISO

Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

EXP

[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]
Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein

PMID:15652244 PMID:17686906 PMID:19766108

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

ISO
EXP

[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA
Spironolactone results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein

PMID:15833929 PMID:17686906

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily G member 5

decreases expression

EXP

Spironolactone results in decreased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

ATP binding cassette subfamily G member 8

decreases expression

EXP

Spironolactone results in decreased expression of ABCG8 mRNA

NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730

G

angiotensin I converting enzyme

multiple interactions
affects expression
decreases expression

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]
Spironolactone affects the expression of ACE protein
Spironolactone results in decreased expression of ACE protein

PMID:15932931 PMID:18586661 PMID:30734886

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

angiotensin converting enzyme 2

increases expression
affects expression

EXP

Spironolactone results in increased expression of ACE2 protein
Spironolactone affects the expression of ACE2 protein

PMID:18586661 PMID:30734886

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

actin alpha 2, smooth muscle

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]; Spironolactone inhibits the reaction [Angiotensin II results in increased expression of ACTA2 mRNA]

PMID:25204689 PMID:39218321

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO
EXP

Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]

PMID:29782964 PMID:33359182

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

angiotensinogen

decreases expression
multiple interactions
increases expression

EXP
ISO

Spironolactone results in decreased expression of AGT protein modified form
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]
Spironolactone results in increased expression of AGT protein modified form

PMID:7357812 PMID:9595286 PMID:19114643 PMID:23288202

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

decreases expression

EXP

Spironolactone results in decreased expression of AGTR1 protein

PMID:18586661 PMID:19114643

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

angiotensin II receptor, type 2

increases expression

EXP

Spironolactone results in increased expression of AGTR2 protein

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

aryl hydrocarbon receptor

increases expression

ISO

Spironolactone results in increased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldehyde dehydrogenase 1 family, member A1

increases expression

ISO

Spironolactone results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member B1

increases expression

ISO

Spironolactone results in increased expression of ALDH1B1 mRNA

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365

G

aldehyde dehydrogenase 4 family, member A1

increases expression

ISO

Spironolactone results in increased expression of ALDH4A1 mRNA

NCBI chr 5:157,163,189...157,188,673
Ensembl chr 5:157,162,945...157,188,673

G

aldehyde dehydrogenase 8 family, member A1

increases expression

ISO

Spironolactone results in increased expression of ALDH8A1 mRNA

NCBI chr 1:18,003,507...18,022,952
Ensembl chr 1:18,003,514...18,023,883

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

aquaporin 2

multiple interactions

EXP

[Spironolactone co-treated with Lithium] affects the expression of AQP2 protein

NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319

G

androgen receptor

affects binding
multiple interactions

ISO
EXP

Spironolactone binds to AR protein
Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]

PMID:10053169 PMID:14565775 PMID:14751673 PMID:15589981 PMID:18324785 More...

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

BCL2-associated agonist of cell death

increases phosphorylation
decreases expression

EXP

Spironolactone results in increased phosphorylation of BAD protein
Spironolactone results in decreased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2, apoptosis regulator

increases expression

EXP

Spironolactone results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

increases expression

EXP

Spironolactone results in increased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

beclin 1

increases expression

EXP

Spironolactone results in increased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 3

multiple interactions
increases activity
decreases activity

EXP
ISO

Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]
Spironolactone results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein]
Spironolactone results in decreased activity of CASP3 protein

PMID:19114643 PMID:20609311 PMID:22700542

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions
increases activity

ISO

Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions

EXP

Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

EXP

Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]

Ensembl chr 5:159,391,188...159,409,648

G

cellular communication network factor 2

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein]

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

EXP

Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA]

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

carboxylesterase 2C

increases expression

ISO

Spironolactone results in increased expression of CES2C mRNA

NCBI chr 1:270,377,201...270,384,768
Ensembl chr 1:270,374,913...270,384,801

G

collagen type I alpha 1 chain

multiple interactions

EXP

Spironolactone inhibits the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

decreases expression
multiple interactions

ISO
EXP

Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form
Spironolactone inhibits the reaction [Angiotensin II results in increased expression of COL3A1 mRNA]

PMID:9302344 PMID:11300427 PMID:15842549 PMID:39218321

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

citrate synthase

multiple interactions

EXP

[[Dexamethasone co-treated with Spironolactone] results in increased abundance of Glucocorticoids] which results in increased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

colony stimulating factor 2

multiple interactions

ISO

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

cardiotrophin 1

multiple interactions

EXP

Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein]

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395

G

C-X-C motif chemokine ligand 1

decreases expression

EXP

Spironolactone results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

cytochrome b-245 beta chain

decreases expression

EXP

Spironolactone results in decreased expression of CYBB protein

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

EXP

Spironolactone results in increased expression of CYP11B2 mRNA

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

ISO

Spironolactone results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

ISO

Spironolactone results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

EXP

NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450 family 7 subfamily A member 1

decreases activity

EXP

Spironolactone results in decreased activity of CYP7A1 protein

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

ETS proto-oncogene 1, transcription factor

increases expression

EXP

Spironolactone results in increased expression of ETS1 protein

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

fatty acid binding protein 4

multiple interactions

ISO

Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

growth arrest specific 6

multiple interactions
affects expression

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]
Spironolactone affects the expression of GAS6 protein

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]

PMID:24512358 PMID:25204689

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

gamma-glutamyltransferase 1

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased activity of GGT1 protein]

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [Spironolactone results in increased expression of GREB1 mRNA]

NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126

G

glutathione-disulfide reductase

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase mu 1

increases expression

ISO

Spironolactone results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

increases expression

ISO

Spironolactone results in increased expression of GSTM2 mRNA; Spironolactone results in increased expression of GSTM5 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase, mu 5

increases expression

ISO

Spironolactone results in increased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

hypoxia inducible factor 1 subunit alpha

increases expression

EXP

Spironolactone results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

increases expression
multiple interactions

EXP

Spironolactone results in increased expression of HMOX1 mRNA; Spironolactone results in increased expression of HMOX1 protein
Spironolactone inhibits the reaction [Angiotensin II results in decreased expression of HMOX1 mRNA]

PMID:21263376 PMID:39218321

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heparanase

multiple interactions

EXP

[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]

NCBI chr14:9,200,971...9,241,377
Ensembl chr14:9,188,275...9,241,754

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

ISO

Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

EXP

Spironolactone results in decreased expression of HSD11B2 mRNA

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

interferon gamma

multiple interactions

ISO

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

ISO

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 18

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions
increases expression

ISO

[Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein
Spironolactone results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 6

multiple interactions

ISO
EXP

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein]
Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]

PMID:17051331 PMID:30993381 PMID:33359182 PMID:37328115

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions

ISO

Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

Janus kinase 2

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

lactate dehydrogenase A

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased activity of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

luteinizing hormone subunit beta

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

microtubule-associated protein 1 light chain 3 beta

increases expression

EXP

Spironolactone results in increased expression of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microsomal glutathione S-transferase 1

increases expression

ISO

Spironolactone results in increased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

matrix metallopeptidase 2

multiple interactions

EXP

Spironolactone inhibits the reaction [Angiotensin II results in increased expression of MMP2 mRNA]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

myeloperoxidase

multiple interactions

EXP

Spironolactone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallothionein 1A

multiple interactions

EXP

Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]

PMID:17616752 PMID:19333130

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metal-regulatory transcription factor 1

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]

NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810

G

MYB proto-oncogene like 1

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [Spironolactone results in increased expression of MYBL1 mRNA]

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

neutrophil cytosolic factor 2

decreases expression

EXP

Spironolactone results in decreased expression of NCF2 protein

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

NFE2 like bZIP transcription factor 2

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Spironolactone inhibits the reaction [Angiotensin II results in decreased expression of NFE2L2 mRNA]

PMID:25204689 PMID:39218321

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NLR family, pyrin domain containing 3

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NPHS1 adhesion molecule, nephrin

multiple interactions

ISO

Spironolactone inhibits reaction [sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney]

RGD

NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:94,848,261...94,876,521

G

NPHS2 stomatin family member, podocin

increases expression

EXP

Spironolactone results in increased expression of NPHS2 protein

NCBI chr13:70,993,622...71,011,585
Ensembl chr13:70,999,186...71,011,572

G

natriuretic peptide A

decreases expression
multiple interactions

ISO
EXP

Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form
Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:9595286 PMID:11300427 PMID:19966502 PMID:23288202

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

decreases expression
multiple interactions

ISO

Spironolactone results in decreased expression of NPPB protein
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein

PMID:11300427 PMID:21378469

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression

ISO
EXP

[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein
NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein
Spironolactone results in increased expression of NR1I2 mRNA
NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]

PMID:11752103 PMID:15833929 PMID:15919853 PMID:16054614 PMID:17627975 More...

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 3, group C, member 2

decreases expression
multiple interactions
increases activity

EXP
ISO

Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein
Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Spironolactone results in increased activity of NR3C2 protein
Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]

PMID:15780662 PMID:17587755 PMID:19114643 PMID:19966502 PMID:22798426 More...

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

oxidized low density lipoprotein receptor 1

multiple interactions

ISO

Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein]

NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598

G

proprotein convertase subtilisin/kexin type 9

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased expression of and results in increased secretion of PCSK9 protein]

NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507

G

plasminogen activator, tissue type

increases expression

ISO

Spironolactone results in increased expression of PLAT protein

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

proopiomelanocortin

multiple interactions

EXP

Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

paraoxonase 3

increases hydrolysis

ISO

PON3 protein results in increased hydrolysis of Spironolactone

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

Spironolactone results in increased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

prolactin

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein]

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

Rac family small GTPase 1

decreases expression

EXP

Spironolactone results in decreased expression of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

renin

multiple interactions
decreases response to substance
increases expression

ISO

[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
REN protein results in decreased susceptibility to Spironolactone
Spironolactone results in increased expression of REN protein

PMID:6998872 PMID:9595286 PMID:12014310 PMID:20016520

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

serpin family E member 1

decreases expression

ISO

Spironolactone results in decreased expression of SERPINE1 protein

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serum/glucocorticoid regulated kinase 1

multiple interactions
increases expression

EXP
ISO

Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA]

PMID:19429930 PMID:33405908

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

sex hormone binding globulin

multiple interactions

EXP

Spironolactone inhibits the reaction [Letrozole results in decreased secretion of SHBG protein]

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

solute carrier family 12 member 2

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein]

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470

G

solute carrier family 22 member 1

multiple interactions

ISO

Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Spironolactone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

multiple interactions

ISO

Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 22 member 4

multiple interactions

ISO

Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,634,098...38,679,920

G

solute carrier family 22 member 5

multiple interactions

ISO

Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 30 member 1

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA]

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 39 member 1

multiple interactions

EXP

Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA]

NCBI chr 2:178,001,052...178,006,689
Ensembl chr 2:178,001,119...178,006,689

G

solute carrier organic anion transporter family, member 1a4

increases expression

ISO

Spironolactone results in increased expression of SLCO1A4 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

solute carrier organic anion transporter family member 1B2

decreases expression

ISO

Spironolactone results in decreased expression of SLCO1B2 mRNA

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

solute carrier organic anion transporter family, member 2a1

decreases expression

ISO

Spironolactone results in decreased expression of SLCO2A1 mRNA

NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921

G

solute carrier organic anion transporter family, member 2b1

decreases expression

ISO

Spironolactone results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279

G

superoxide dismutase 1

multiple interactions

EXP

Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]

PMID:17616752 PMID:19333130

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

trefoil factor 1

increases expression

ISO

Spironolactone results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

transforming growth factor, beta 1

decreases expression
multiple interactions

EXP

Spironolactone results in decreased expression of TGFB1 protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]; Spironolactone inhibits the reaction [Angiotensin II results in increased expression of TGFB1 mRNA]

PMID:15130897 PMID:16928621 PMID:25204689 PMID:39218321

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tenascin C

multiple interactions

EXP

Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

multiple interactions

ISO
EXP

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]

PMID:16528473 PMID:17051331 PMID:33359182

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

UDP glucuronosyltransferase family 1 member A1

increases expression
increases activity

EXP
ISO

Spironolactone results in increased expression of UGT1A1 mRNA
Spironolactone results in increased activity of UGT1A1 protein

PMID:12818378 PMID:19144771

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ISO

Spironolactone results in increased expression of UGT1A2 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression
increases activity

EXP

Spironolactone results in increased expression of UGT1A5 mRNA
Spironolactone results in increased activity of UGT1A5 protein

NCBI chr 9:96,228,134...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases expression

ISO

Spironolactone results in increased expression of UGT1A5 mRNA

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases expression
increases activity
multiple interactions

EXP

Spironolactone results in increased expression of UGT1A7 protein
Spironolactone results in increased activity of UGT1A7 protein
[Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein

NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases expression

ISO

Spironolactone results in increased expression of UGT1A9 mRNA

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

vascular endothelial growth factor A

increases expression

EXP

Spironolactone results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WT1 transcription factor

increases expression

EXP

Spironolactone results in increased expression of WT1 protein

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ISO

ABCB1 protein results in increased transport of Strophanthidin

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

ISO

Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

interleukin 17A

multiple interactions

ISO

Strophanthidin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17F

multiple interactions

ISO

Strophanthidin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:30,686,538...30,697,918

G

neuronal PAS domain protein 2

increases expression
multiple interactions

ISO

Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

RAR-related orphan receptor C

multiple interactions
increases expression

ISO

RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

Telocinobufagin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymidylate synthetase

decreases expression

ISO

telocinobufagin results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA]

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

ADAM metallopeptidase domain 17

multiple interactions

ISO

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

AKT serine/threonine kinase 1

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arachidonate 15-lipoxygenase

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein]

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

activating transcription factor 4

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

BCL2-associated agonist of cell death

multiple interactions

ISO

withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

withaferin A results in decreased expression of BCL2 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]

PMID:20438634 PMID:21256832 PMID:21964475 PMID:35734936

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

multiple interactions

ISO

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 11

decreases expression
multiple interactions

ISO
EXP

withaferin A results in decreased expression of BCL2L11 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]

PMID:20438634 PMID:35734936

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

caspase 3

multiple interactions

EXP
ISO

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]
withaferin A inhibits the reaction [Elements, Radioactive results in increased activity of CASP3 protein]

PMID:35734936 PMID:36716864

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
increases expression

EXP
ISO

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein]
withaferin A results in increased expression of CAT protein

PMID:35734936 PMID:36716864

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

multiple interactions

ISO

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cadherin 1

increases expression
multiple interactions

ISO

withaferin A results in increased expression of CDH1 protein
VIM protein mutant form inhibits the reaction [withaferin A results in increased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 2

multiple interactions
decreases expression

ISO

VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of CDH2 protein]

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase inhibitor 1A

affects binding
multiple interactions
increases expression

ISO

withaferin A binds to CDKN1A protein
withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CDKN2A interacting protein

decreases expression

ISO

withaferin A results in decreased expression of CDKN2AIP protein

NCBI chr16:51,266,613...51,274,051
Ensembl chr16:51,268,896...51,274,049

G

claudin 1

decreases response to substance
decreases expression

ISO

CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

ceruloplasmin

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein]

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

carnitine palmitoyltransferase 1c

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA]

NCBI chr 1:104,579,297...104,593,824
Ensembl chr 1:104,579,298...104,593,763

G

C-reactive protein

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein]

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

DNA-damage inducible transcript 3

affects response to substance
multiple interactions
increases expression

ISO

DDIT3 mRNA affects the susceptibility to withaferin A
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DNA methyltransferase 1

decreases expression

ISO

withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

decreases expression

ISO

withaferin A results in decreased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

DNA methyltransferase 3 beta

decreases expression

ISO

withaferin A results in decreased expression of DNMT3B mRNA

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

EGF like repeats and discoidin domains 3

decreases expression

ISO

withaferin A results in decreased expression of EDIL3 mRNA

NCBI chr 2:21,625,604...22,140,380
Ensembl chr 2:21,625,596...22,140,379

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

multiple interactions

ISO

withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA]

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 2A

increases phosphorylation

ISO

withaferin A results in increased phosphorylation of EIF2A protein

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201

G

ezrin

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

Fas cell surface death receptor

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fatty acid synthase

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

withaferin A results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

ISO

withaferin A results in decreased expression of G6PC1 protein

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamic--pyruvic transaminase

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

ISO

withaferin A binds to and affects the localization of GSR protein

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

histone deacetylase 1

decreases expression

ISO

withaferin A results in decreased expression of HDAC1 protein

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

heme oxygenase 1

increases expression

ISO

withaferin A results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

heat shock transcription factor 1

increases activity

ISO

withaferin A results in increased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein family A (Hsp70) member 9

affects binding
multiple interactions

ISO

withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]

PMID:22973447 PMID:25236891

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

interleukin 1 beta

multiple interactions

ISO

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:24632454 PMID:37467946

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO
EXP

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]

PMID:20438634 PMID:35734936

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

keratin 13

decreases expression

ISO

withaferin A results in decreased expression of KRT13 mRNA

NCBI chr10:85,552,287...85,556,499
Ensembl chr10:85,552,287...85,556,499

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]

PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation

ISO

withaferin A results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
increases expression

ISO

MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

methyl CpG binding protein 2

decreases expression

ISO

withaferin A results in decreased expression of MECP2 protein

NCBI chr X:156,932,481...156,995,981
Ensembl chr X:156,941,234...156,943,560

G

matrix metallopeptidase 2

multiple interactions
decreases expression

ISO

[withanone co-treated with withaferin A] results in decreased expression of MMP2 protein; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP2 protein]

PMID:25236891 PMID:39613173

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

decreases expression
multiple interactions

ISO

withaferin A results in decreased expression of MMP9 protein
VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

neural precursor cell expressed, developmentally down-regulated 9

multiple interactions
decreases expression

ISO

[withaferin A results in increased phosphorylation of VIM protein] inhibits the reaction [NEDD9 protein binds to VIM protein]; withaferin A inhibits the reaction [NEDD9 protein binds to VIM protein]
withaferin A results in decreased expression of NEDD9 protein

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668

G

NFE2 like bZIP transcription factor 2

affects binding
increases phosphorylation

ISO

withaferin A binds to NFE2L2 protein
withaferin A results in increased phosphorylation of NFE2L2 protein

PMID:22973447 PMID:36716864

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

EXP

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

5' nucleotidase, ecto

increases expression

ISO

withaferin A results in increased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]

PMID:20438634 PMID:24019090

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

peroxiredoxin 2

increases expression

ISO

withaferin A results in increased expression of PRDX2 protein

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

protein C receptor

multiple interactions

ISO

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]

NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

serpin family A member 6

decreases expression

ISO

withaferin A results in decreased expression of SERPINA6 protein

NCBI chr 6:128,544,828...128,555,064
Ensembl chr 6:128,544,831...128,555,139

G

solute carrier organic anion transporter family, member 4a1

increases expression

ISO

withaferin A results in increased expression of SLCO4A1 mRNA

NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:187,936,820...187,955,871

G

snail family transcriptional repressor 1

decreases expression

ISO

withaferin A results in decreased expression of SNAI1 protein

NCBI chr 3:176,667,476...176,671,965

G

superoxide dismutase 2

multiple interactions
increases expression

ISO

SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]
withaferin A results in increased expression of SOD2 protein

PMID:24019090 PMID:36716864

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sterol regulatory element binding transcription factor 2

multiple interactions

ISO

withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA]

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

signal transducer and activator of transcription 1

multiple interactions

ISO

withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions

ISO

withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tyrosine aminotransferase

decreases expression

ISO

withaferin A results in decreased expression of TAT protein

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

thiol methyltransferase 1A

decreases expression

ISO

withaferin A results in decreased expression of TMT1A mRNA

NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:133,330,447...133,338,959

G

tumor necrosis factor

multiple interactions
decreases activity

ISO
EXP

withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]
withaferin A results in decreased activity of TNF protein

PMID:20438634 PMID:24632454 PMID:35734936 PMID:37467946

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

tumor protein p53

increases expression
affects binding
multiple interactions

ISO

withaferin A results in increased expression of TP53 mRNA
withaferin A binds to TP53 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tubulin, alpha 1A

decreases expression

ISO

withaferin A results in decreased expression of TUBA1A mRNA

NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035

G

tubulin, beta 5 class I

decreases expression

ISO

withaferin A results in decreased expression of TUBB mRNA

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

vascular endothelial growth factor A

multiple interactions
decreases expression

ISO

[withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein

PMID:20438634 PMID:25236891

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vimentin

multiple interactions
increases phosphorylation

ISO

[withaferin A results in increased phosphorylation of VIM protein] inhibits the reaction [NEDD9 protein binds to VIM protein]; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of CDH2 protein]; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP2 protein]; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP9 protein]; VIM protein mutant form inhibits the reaction [withaferin A results in increased expression of CDH1 protein]; withaferin A inhibits the reaction [NEDD9 protein binds to VIM protein]
[withaferin A results in increased phosphorylation of VIM protein] inhibits the reaction [NEDD9 protein binds to VIM protein]; withaferin A inhibits the reaction [NEDD9 protein binds to VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

X-box binding protein 1

increases expression
increases splicing

ISO

withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aurora kinase A

multiple interactions

ISO

withanone inhibits the reaction [TPX2 protein binds to AURKA protein]

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

baculoviral IAP repeat-containing 5

multiple interactions

ISO

withanone binds to and results in decreased activity of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO

withanone results in increased expression of CDKN1A mRNA
withanone inhibits the reaction [methoxyacetic acid results in increased expression of CDKN1A protein]; withanone results in increased expression of and affects the localization of and results in increased activity of CDKN1A protein

PMID:21573189 PMID:22973447

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

ISO

withanone inhibits the reaction [methoxyacetic acid results in increased expression of CDKN2A protein]

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

ezrin

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573

G

growth associated protein 43

multiple interactions

ISO

withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

glial fibrillary acidic protein

multiple interactions

ISO

withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withanone binds to and results in decreased activity of HNRNPK protein

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

heat shock protein family A (Hsp70) member 9

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; [withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]

PMID:22155302 PMID:25236891

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

microtubule-associated protein 2

multiple interactions

ISO

withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase 1

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

matrix metallopeptidase 2

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased expression of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

neurofilament heavy chain

multiple interactions

ISO

withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

ISO

withanone results in increased expression of NFE2L2 protein
withanone inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]; withanone inhibits the reaction [methoxyacetic acid results in decreased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

RB transcriptional corepressor 1

multiple interactions

ISO

withanone inhibits the reaction [methoxyacetic acid results in increased phosphorylation of RB1 protein]

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

tumor protein p53

multiple interactions
increases expression

ISO

[withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withanone inhibits the reaction [HSPA9 protein binds to TP53 protein]; withanone inhibits the reaction [methoxyacetic acid results in increased expression of TP53 protein]
withanone results in increased expression of TP53 mRNA

PMID:21573189 PMID:22155302 PMID:22973447

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TPX2, microtubule nucleation factor

multiple interactions

ISO

withanone inhibits the reaction [TPX2 protein binds to AURKA protein]

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:161,778,742...161,820,724

G

vascular endothelial growth factor A

multiple interactions

ISO

[withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
atom	20872
nonmetal atom	20781
carbon atom	20706
organic molecular entity	20706
lipid	17852
steroid	15237
steroid lactone	722
(1S,3aR,3bR,5aS,9aS,9bR,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one	0
(2beta,3beta,5beta)-2,3-diacetoxy-5,14-dihydroxy-19-oxobufa-20,22-dienolide	0
(3beta,9xi)-3,14-Dihydroxycarda-5,20(22)-dienolide	0
(5-Acetyloxy-9,18-dihydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-6-yl)methyl acetate	0
(9S,14S)-10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione	0
1,2-dihydro-16-O-deacetylhelvolic acid 21,16-lactone	0
1,2-dihydro-6,16-O-dideacetylhelvolic acid 21,16-lactone	0
1,7,11-trideacetyl-pyripyropene A	0
10,13-dimethyl-7-methylsulfinylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione	0
10,13-dimethylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione	0
15-hydroxydecaturin A	0
16-O-deacetylhelvolic acid 21,16-lactone	0
17-Hydroxy-3-oxo-17alpha-pregna-1,4-diene-21-carboxylic acid, gamma-lactone	0
17-Hydroxy-3-oxo-19-nor-5alpha,17alpha-pregnane-21-carboxylic acid, gamma-lactone	0
17-Hydroxy-3-oxo-19-nor-5beta,17alpha-pregnane-21-carboxylic acid, gamma-lactone	0
17beta-Acetyl-1,2,3,4,6alpha,7alpha,10,12,13,14alpha,16,17-dodecahydro-3beta-hydroxy-10beta,13beta-dimethyl-5beta,8beta-etheno-15H-cyclopenta[a]phenanthrene-6,7-dicarboxylic anhydride acetate	0
17beta-Hydroxy-2-oxa-5alpha-androstan-3-one	0
17beta-Hydroxy-4-oxa-5alpha-androstan-3-one acetate	0
24-epi-6beta,16beta-diacetoxy-25-hydroxy-3,7-dioxo-29-nordammara-1,17(20)-diene-21,24-lactone	0
3,14-Dihydroxycarda-5,20(22)-dienolide	0
3-hydroxy-9a,11a-dimethyl-3,3a,3b,8,9,9b,10,11-octahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
3-oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	0
4-methanesulfonyl-9a,11a-dimethyl-3,3a,3b,4,5,8,9,9b,10,11-decahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one	0
5-[14-hydroxy-10,13-dimethyl-3-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxy]-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-pyranone	0
5-hydroxy-4-methanesulfinyl-9a,11a-dimethyl-3,3a,3b,4,5,8,9,9b,10,11-decahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
5-hydroxy-4-methanesulfonyl-9a,11a-dimethyl-3,3a,3b,4,5,8,9,9b,10,11-decahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
5beta-hydroxybufotalin	0
6,7-dihydrocanrenone	0
6-O-propionyl-6,16-O-dideacetylhelvolic acid 21,16-lactone	0
6-hydroxy-7-(thiomethyl)spironolactone	0
7 -thiospironolactone	0
7-Acetoxy-6-hydroxylimonin	0
7-deacetylpyripyropene A	0
7-nor-ergosterolide	0
7-thiomethylspironolactone	0
7alpha-Hydroxyparavallarine	0
Aperterpene O	0
Arenobufagin	4
Aspermeroterpene B	0
Aspermeroterpene C	0
Asperterpene M	0
Bryophyllin A	0
Bufotalin	339
Bufotalin 3-succinoylarginine ester	0
Calamin	0
Cinobufagin	39
Cinobufotalin	10
Cyclocalamin	0
D-Homo-A-nor-17a-oxaandrost-3(5)-ene-2,17-dione	0
Daturilinol	0
Deacetylnomilinic acid	0
Deacetylspironolactone	0
Desoxylimonin	0
Dhilirolide K	0
Dicirenone	0
Eurycomalactone	0
Gamabufogenin	0
Glucoscilliroside	0
Hawaiinolide A	0
Hawaiinolide C	0
Hawaiinolide D	0
Hellebrigenin 3-acetate	0
Hellebrigenin glucoside	0
Icacine	0
Isocyclocalamin	0
Isolimonic acid 16->17-lactone	0
Jangomolide	0
Kibalaurifenone	0
LSM-1524	0
Lanceotoxin A	0
Lanceotoxin B	0
Lycopersiconolide	0
Neriantogenin	0
Nomilinic acid	0
Obacunoic acid	0
Pyripyropene T	0
Rutaevin	1
Scillipheosidin 3-[glucosyl-(1->2)-rhamnoside]	0
Sonolisib	0
Sonomolide A	0
Telocinobufagin	1
Terretonin A	0
Terretonin B	0
Terretonin C	0
Terretonin E	0
Terretonin F	0
Terretonin M	0
Terretonin N	0
Terreusterpene C	0
Terreustoxin A	0
Terreustoxin B	0
Terreustoxin C	0
Terreustoxin E	0
Terreustoxin F	0
Terreustoxin H	0
Terreustoxin I	0
Terreustoxin L	0
Tetrahydroaldosterone	0
Withanone	19
Wortmannine E	0
Zythiostromolid	0
abrusoside A	0
ajugalactone	0
asterasterol A	0
bufadienolides +	0
bufanolide +	0
bufogenin	2
calcitriol 26,23-lactone	0
canrenone	0
cardanolide +	0
cardenolides +	261
cardiac glycoside +	261
convallatoxin	0
cyasterone	0
drospirenone	10
elaeodendroside B	0
elaeodendroside F	0
elaeodendroside G	0
elaeodendroside T	0
elaeodendroside V	0
elaeodendroside W	0
ethanethioic acid S-(10,13-dimethyl-3,5'-dioxo-7-spiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]yl) ester	0
hellebrigenin	8
helveticoside	1
lucibufagin C	0
meproscillarin	0
methyl (E)-3-[18-acetyloxy-7-(furan-3-yl)-17-hydroxy-1,8,15,15-tetramethyl-5-oxo-3,6,14-trioxapentacyclo[9.7.0.02,4.02,8.012,16]octadecan-12-yl]prop-2-enoate	0
resibufagenin	0
sarmentologenin	0
scillirosidin	0
spironolactone	124
testololactone	0
withalongolide F	0
withanolide +	85
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
heteroorganic entity	20201
organochalcogen compound	19822
organooxygen compound	19713
ester	17841
carboxylic ester	17347
lactone	13231
steroid lactone	722
(1S,3aR,3bR,5aS,9aS,9bR,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one	0
(2beta,3beta,5beta)-2,3-diacetoxy-5,14-dihydroxy-19-oxobufa-20,22-dienolide	0
(3beta,9xi)-3,14-Dihydroxycarda-5,20(22)-dienolide	0
(5-Acetyloxy-9,18-dihydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-6-yl)methyl acetate	0
(9S,14S)-10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione	0
1,2-dihydro-16-O-deacetylhelvolic acid 21,16-lactone	0
1,2-dihydro-6,16-O-dideacetylhelvolic acid 21,16-lactone	0
1,7,11-trideacetyl-pyripyropene A	0
10,13-dimethyl-7-methylsulfinylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione	0
10,13-dimethylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione	0
15-hydroxydecaturin A	0
16-O-deacetylhelvolic acid 21,16-lactone	0
17-Hydroxy-3-oxo-17alpha-pregna-1,4-diene-21-carboxylic acid, gamma-lactone	0
17-Hydroxy-3-oxo-19-nor-5alpha,17alpha-pregnane-21-carboxylic acid, gamma-lactone	0
17-Hydroxy-3-oxo-19-nor-5beta,17alpha-pregnane-21-carboxylic acid, gamma-lactone	0
17beta-Acetyl-1,2,3,4,6alpha,7alpha,10,12,13,14alpha,16,17-dodecahydro-3beta-hydroxy-10beta,13beta-dimethyl-5beta,8beta-etheno-15H-cyclopenta[a]phenanthrene-6,7-dicarboxylic anhydride acetate	0
17beta-Hydroxy-2-oxa-5alpha-androstan-3-one	0
17beta-Hydroxy-4-oxa-5alpha-androstan-3-one acetate	0
24-epi-6beta,16beta-diacetoxy-25-hydroxy-3,7-dioxo-29-nordammara-1,17(20)-diene-21,24-lactone	0
3,14-Dihydroxycarda-5,20(22)-dienolide	0
3-hydroxy-9a,11a-dimethyl-3,3a,3b,8,9,9b,10,11-octahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
3-oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	0
4-methanesulfonyl-9a,11a-dimethyl-3,3a,3b,4,5,8,9,9b,10,11-decahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one	0
5-[14-hydroxy-10,13-dimethyl-3-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxy]-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-pyranone	0
5-hydroxy-4-methanesulfinyl-9a,11a-dimethyl-3,3a,3b,4,5,8,9,9b,10,11-decahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
5-hydroxy-4-methanesulfonyl-9a,11a-dimethyl-3,3a,3b,4,5,8,9,9b,10,11-decahydro-2H-spiro[cyclopenta[a]phenanthrene-1,2'-oxolane]-5',7-dione	0
5beta-hydroxybufotalin	0
6,7-dihydrocanrenone	0
6-O-propionyl-6,16-O-dideacetylhelvolic acid 21,16-lactone	0
6-hydroxy-7-(thiomethyl)spironolactone	0
7 -thiospironolactone	0
7-Acetoxy-6-hydroxylimonin	0
7-deacetylpyripyropene A	0
7-nor-ergosterolide	0
7-thiomethylspironolactone	0
7alpha-Hydroxyparavallarine	0
Aperterpene O	0
Arenobufagin	4
Aspermeroterpene B	0
Aspermeroterpene C	0
Asperterpene M	0
Bryophyllin A	0
Bufotalin	339
Bufotalin 3-succinoylarginine ester	0
Calamin	0
Cinobufagin	39
Cinobufotalin	10
Cyclocalamin	0
D-Homo-A-nor-17a-oxaandrost-3(5)-ene-2,17-dione	0
Daturilinol	0
Deacetylnomilinic acid	0
Deacetylspironolactone	0
Desoxylimonin	0
Dhilirolide K	0
Dicirenone	0
Eurycomalactone	0
Gamabufogenin	0
Glucoscilliroside	0
Hawaiinolide A	0
Hawaiinolide C	0
Hawaiinolide D	0
Hellebrigenin 3-acetate	0
Hellebrigenin glucoside	0
Icacine	0
Isocyclocalamin	0
Isolimonic acid 16->17-lactone	0
Jangomolide	0
Kibalaurifenone	0
LSM-1524	0
Lanceotoxin A	0
Lanceotoxin B	0
Lycopersiconolide	0
Neriantogenin	0
Nomilinic acid	0
Obacunoic acid	0
Pyripyropene T	0
Rutaevin	1
Scillipheosidin 3-[glucosyl-(1->2)-rhamnoside]	0
Sonolisib	0
Sonomolide A	0
Telocinobufagin	1
Terretonin A	0
Terretonin B	0
Terretonin C	0
Terretonin E	0
Terretonin F	0
Terretonin M	0
Terretonin N	0
Terreusterpene C	0
Terreustoxin A	0
Terreustoxin B	0
Terreustoxin C	0
Terreustoxin E	0
Terreustoxin F	0
Terreustoxin H	0
Terreustoxin I	0
Terreustoxin L	0
Tetrahydroaldosterone	0
Withanone	19
Wortmannine E	0
Zythiostromolid	0
abrusoside A	0
ajugalactone	0
asterasterol A	0
bufadienolides +	0
bufanolide +	0
bufogenin	2
calcitriol 26,23-lactone	0
canrenone	0
cardanolide +	0
cardenolides +	261
cardiac glycoside +	261
convallatoxin	0
cyasterone	0
drospirenone	10
elaeodendroside B	0
elaeodendroside F	0
elaeodendroside G	0
elaeodendroside T	0
elaeodendroside V	0
elaeodendroside W	0
ethanethioic acid S-(10,13-dimethyl-3,5'-dioxo-7-spiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]yl) ester	0
hellebrigenin	8
helveticoside	1
lucibufagin C	0
meproscillarin	0
methyl (E)-3-[18-acetyloxy-7-(furan-3-yl)-17-hydroxy-1,8,15,15-tetramethyl-5-oxo-3,6,14-trioxapentacyclo[9.7.0.02,4.02,8.012,16]octadecan-12-yl]prop-2-enoate	0
resibufagenin	0
sarmentologenin	0
scillirosidin	0
spironolactone	124
testololactone	0
withalongolide F	0
withanolide +	85

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