CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | steroid lactone |
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Accession: | CHEBI:26766
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browse the term
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Synonyms: | related_synonym: | steroid lactones |
| xref: | KEGG:C15507 |
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Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
bufalin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] |
CTD |
PMID:23104431 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Actb |
actin, beta |
increases expression |
ISO |
bufalin results in increased expression of ACTB protein |
CTD |
PMID:23091618 |
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NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Actg1 |
actin, gamma 1 |
increases expression |
ISO |
bufalin results in increased expression of ACTG1 protein |
CTD |
PMID:23091618 |
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NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232 Ensembl chr 3:105,619,737...105,624,232
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
bufalin results in increased phosphorylation of and results in decreased expression of AKT1 protein bufalin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:23949904 PMID:36924737 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
bufalin results in increased expression of APAF1 protein |
CTD |
PMID:27444971 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
bufalin results in decreased expression of BCL2 mRNA; bufalin results in decreased expression of BCL2 protein |
CTD |
PMID:7658701 PMID:27444971 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
bufalin results in increased expression of BCL2L11 protein |
CTD |
PMID:36924737 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Casp3 |
caspase 3 |
increases expression increases activity |
ISO |
bufalin results in increased expression of CASP3 mRNA; bufalin results in increased expression of CASP3 protein modified form bufalin results in increased activity of CASP3 protein |
CTD |
PMID:27444971 PMID:36924737 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9 |
caspase 9 |
increases activity |
ISO |
bufalin results in increased activity of CASP9 protein |
CTD |
PMID:27444971 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cope |
COPI coat complex subunit epsilon |
decreases expression |
ISO |
bufalin results in decreased expression of COPE protein |
CTD |
PMID:23091618 |
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NCBI chr16:19,114,871...19,125,076
Ensembl chr16:19,114,871...19,128,907
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Cycs |
cytochrome c, somatic |
multiple interactions increases expression |
ISO |
bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]] bufalin results in increased expression of CYCS protein |
CTD |
PMID:23091618 PMID:27444971 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing multiple interactions increases expression |
ISO |
CYP3A4 protein results in increased metabolism of bufalin bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; bufalin results in increased expression of and results in increased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin] bufalin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:22178124 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
bufalin results in increased expression of DDIT3 mRNA |
CTD |
PMID:27444971 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
increases expression |
ISO |
bufalin results in increased expression of DNAJB11 protein |
CTD |
PMID:23091618 |
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NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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Dut |
deoxyuridine triphosphatase |
decreases expression |
ISO |
bufalin results in decreased expression of DUT protein |
CTD |
PMID:23091618 |
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NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
decreases phosphorylation |
ISO |
bufalin results in decreased phosphorylation of EIF2AK3 protein |
CTD |
PMID:23949904 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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Endog |
endonuclease G |
increases expression |
ISO |
bufalin results in increased expression of ENDOG mRNA; bufalin results in increased expression of ENDOG protein |
CTD |
PMID:27444971 |
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NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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Eno1 |
enolase 1 |
decreases expression |
ISO |
bufalin results in decreased expression of ENO1 protein |
CTD |
PMID:23091618 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Fas |
Fas cell surface death receptor |
increases expression |
ISO |
bufalin results in increased expression of FAS protein |
CTD |
PMID:27444971 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg |
Fas ligand |
increases expression |
ISO |
bufalin results in increased expression of FASLG protein |
CTD |
PMID:27444971 PMID:36924737 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of FOS mRNA] |
CTD |
PMID:10712238 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
bufalin results in increased expression of and results in decreased phosphorylation of FOXO1 protein |
CTD |
PMID:36924737 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
bufalin results in decreased expression of GRB2 protein |
CTD |
PMID:23949904 |
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NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
bufalin results in decreased expression of GSTP1 protein |
CTD |
PMID:23091618 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
decreases expression |
ISO |
bufalin results in decreased expression of HNRNPH1 protein |
CTD |
PMID:23091618 |
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NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
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Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
decreases expression |
ISO |
bufalin results in decreased expression of HNRNPK protein |
CTD |
PMID:23091618 |
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NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
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Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression |
ISO |
bufalin results in decreased expression of HSPA5 mRNA |
CTD |
PMID:27444971 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions decreases response to substance decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein]; bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]; HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein] HSPB1 protein results in decreased susceptibility to bufalin |
CTD |
PMID:23091618 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; SB 203580 promotes the reaction [bufalin results in increased expression of IL1B mRNA] |
CTD |
PMID:10712238 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation |
ISO |
bufalin results in decreased phosphorylation of JUN protein |
CTD |
PMID:23949904 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Krt18 |
keratin 18 |
increases expression |
ISO |
bufalin results in increased expression of KRT18 protein |
CTD |
PMID:23091618 |
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NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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Map2k7 |
mitogen activated protein kinase kinase 7 |
decreases expression |
ISO |
bufalin results in decreased expression of MAP2K7 protein |
CTD |
PMID:23949904 |
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NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
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Map3k3 |
mitogen activated protein kinase kinase kinase 3 |
decreases expression |
ISO |
bufalin results in decreased expression of MAP3K3 protein |
CTD |
PMID:23949904 |
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NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
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Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation decreases activity increases phosphorylation |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK1 protein] bufalin results in decreased phosphorylation of MAPK1 protein bufalin results in decreased activity of MAPK1 protein |
CTD |
PMID:10712238 PMID:21922632 PMID:36924737 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation decreases activity increases phosphorylation |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK3 protein] bufalin results in decreased phosphorylation of MAPK3 protein bufalin results in decreased activity of MAPK3 protein |
CTD |
PMID:10712238 PMID:21922632 PMID:36924737 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8 |
mitogen-activated protein kinase 8 |
decreases activity |
ISO |
bufalin results in decreased activity of MAPK8 protein |
CTD |
PMID:21922632 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9 |
mitogen-activated protein kinase 9 |
decreases activity |
ISO |
bufalin results in decreased activity of MAPK9 protein |
CTD |
PMID:21922632 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
bufalin co-treated with osimertinib decreases expression of MCL1 protein in lung Bufalin decreases expression of MCL1 protein in lung |
RGD |
PMID:31301315 PMID:28419994 |
RGD:151356917, RGD:151356918 |
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
bufalin results in decreased expression of MKI67 protein |
CTD |
PMID:36924737 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp1 |
matrix metallopeptidase 1 |
decreases expression |
ISO |
bufalin results in decreased expression of MMP1 protein |
CTD |
PMID:23949904 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases secretion decreases expression |
ISO |
bufalin results in decreased expression of and results in decreased activity of MMP2 protein bufalin results in decreased secretion of MMP2 protein bufalin results in decreased expression of MMP2 mRNA |
CTD |
PMID:21922632 PMID:23949904 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9 |
matrix metallopeptidase 9 |
decreases activity decreases secretion multiple interactions decreases expression |
ISO |
bufalin results in decreased activity of MMP9 protein bufalin results in decreased secretion of MMP9 protein bufalin results in decreased expression of and results in decreased activity of MMP9 protein bufalin results in decreased expression of MMP9 mRNA |
CTD |
PMID:21922632 PMID:23949904 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
bufalin results in decreased expression of MYC mRNA |
CTD |
PMID:7658701 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nos2 |
nitric oxide synthase 2 |
decreases expression |
ISO |
bufalin results in decreased expression of NOS2 protein |
CTD |
PMID:23949904 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
bufalin results in increased cleavage of PARP1 protein HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein] |
CTD |
PMID:23091618 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Ppa1 |
inorganic pyrophosphatase 1 |
decreases expression |
ISO |
bufalin results in decreased expression of PPA1 protein |
CTD |
PMID:23091618 |
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NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
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Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
ISO |
bufalin results in decreased expression of PPP2CB protein |
CTD |
PMID:23091618 |
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NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Psma3 |
proteasome 20S subunit alpha 3 |
decreases expression |
ISO |
bufalin results in decreased expression of PSMA3 protein |
CTD |
PMID:23091618 |
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NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
bufalin results in decreased expression of PTGS2 protein |
CTD |
PMID:23949904 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptk2 |
protein tyrosine kinase 2 |
decreases expression |
ISO |
bufalin results in decreased expression of PTK2 protein |
CTD |
PMID:23949904 |
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NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression multiple interactions affects localization |
ISO |
bufalin results in decreased expression of RELA protein HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein] |
CTD |
PMID:23091618 PMID:23949904 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rhoa |
ras homolog family member A |
decreases expression |
ISO |
bufalin results in decreased expression of RHOA protein |
CTD |
PMID:23949904 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
decreases expression |
ISO |
bufalin results in decreased expression of ROCK1 protein |
CTD |
PMID:23949904 |
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NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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Rplp0 |
ribosomal protein lateral stalk subunit P0 |
decreases expression |
ISO |
bufalin results in decreased expression of RPLP0 protein |
CTD |
PMID:23091618 |
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NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
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Rpsa |
ribosomal protein SA |
increases expression |
ISO |
bufalin results in increased expression of RPSA protein |
CTD |
PMID:23091618 |
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NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
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Sarnp |
SAP domain containing ribonucleoprotein |
increases expression |
ISO |
bufalin results in increased expression of SARNP protein |
CTD |
PMID:23091618 |
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NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332
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Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
decreases expression |
ISO |
bufalin results in decreased expression of SOS1 protein |
CTD |
PMID:23949904 |
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NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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Tardbp |
TAR DNA binding protein |
decreases expression |
ISO |
bufalin results in decreased expression of TARDBP protein |
CTD |
PMID:23091618 |
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NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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Tcp1 |
t-complex 1 |
decreases expression |
ISO |
bufalin results in decreased expression of TCP1 protein |
CTD |
PMID:23091618 |
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NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
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Tmod3 |
tropomodulin 3 |
decreases expression |
ISO |
bufalin results in decreased expression of TMOD3 protein |
CTD |
PMID:23091618 |
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NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977
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Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO |
bufalin results in increased expression of TNF mRNA SB 203580 promotes the reaction [bufalin results in increased expression of TNF mRNA] |
CTD |
PMID:10712238 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tpi1 |
triosephosphate isomerase 1 |
decreases expression |
ISO |
bufalin results in decreased expression of TPI1 protein |
CTD |
PMID:23091618 |
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NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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Tpt1 |
tumor protein, translationally-controlled 1 |
decreases expression |
ISO |
bufalin results in decreased expression of TPT1 protein |
CTD |
PMID:23091618 |
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NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
bufalin results in decreased expression of VEGFA protein |
CTD |
PMID:23949904 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression multiple interactions increases metabolic processing increases activity |
ISO |
bufogenin results in increased expression of CYP3A4 mRNA bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin] bufogenin results in increased activity of CYP3A4 protein |
CTD |
PMID:22178124 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Cardenolides inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] |
CTD |
PMID:23104431 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Anxa1 |
annexin A1 |
increases expression |
ISO |
cinobufagin results in increased expression of ANXA1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
cinobufagin results in increased expression of BAX protein |
CTD |
PMID:23164673 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
cinobufagin results in decreased expression of BCL2 protein |
CTD |
PMID:23164673 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
increases expression |
ISO |
cinobufagin results in increased expression of BHLHE40 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
cinobufagin results in decreased expression of BIRC2 protein |
CTD |
PMID:23164673 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
cinobufagin results in decreased expression of BIRC5 protein |
CTD |
PMID:23164673 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
cinobufagin results in decreased expression of CCNA2 mRNA |
CTD |
PMID:21215801 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Cct3 |
chaperonin containing TCP1 subunit 3 |
decreases expression |
ISO |
cinobufagin results in decreased expression of CCT3 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
cinobufagin results in decreased expression of CDK2 mRNA; cinobufagin results in decreased expression of CDK2 protein cinobufagin results in decreased expression of and results in decreased phosphorylation of CDK2 protein |
CTD |
PMID:21215801 PMID:34619160 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk9 |
cyclin-dependent kinase 9 |
increases expression |
ISO |
cinobufagin results in increased expression of CDK9 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
cinobufagin results in decreased expression of CDKN1A mRNA; cinobufagin results in decreased expression of CDKN1A protein |
CTD |
PMID:21215801 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression increases metabolic processing multiple interactions |
ISO |
cinobufagin results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased metabolism of cinobufagin cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; cinobufagin results in increased expression of and results in increased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin] |
CTD |
PMID:22178124 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dctpp1 |
dCTP pyrophosphatase 1 |
decreases expression |
ISO |
cinobufagin results in decreased expression of DCTPP1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839
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G |
Egfr |
epidermal growth factor receptor |
decreases expression |
ISO |
cinobufagin results in decreased expression of EGFR protein |
CTD |
PMID:34619160 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
cinobufagin results in increased expression of FOS mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Grwd1 |
glutamate-rich WD repeat containing 1 |
decreases expression |
ISO |
cinobufagin results in decreased expression of GRWD1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases expression multiple interactions affects response to substance |
ISO |
cinobufagin results in increased expression of GSK3B protein modified form GSK3B protein mutant form inhibits the reaction [cinobufagin results in decreased expression of RELA protein]; GSK3B protein mutant form inhibits the reaction [cinobufagin results in increased expression of PARP1 protein modified form]; SB 216763 inhibits the reaction [cinobufagin results in increased expression of GSK3B protein modified form] GSK3B protein affects the susceptibility to cinobufagin |
CTD |
PMID:23164673 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
cinobufagin results in increased expression of H2AX protein |
CTD |
PMID:35427566 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
decreases expression |
ISO |
cinobufagin results in decreased expression of HSP90AB1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
cinobufagin results in increased expression of JUN mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
cinobufagin results in increased expression of JUNB mRNA |
CTD |
PMID:35447139 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Klf10 |
KLF transcription factor 10 |
increases expression |
ISO |
cinobufagin results in increased expression of KLF10 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
cinobufagin results in decreased expression of MYC mRNA; cinobufagin results in decreased expression of MYC protein |
CTD |
PMID:21215801 PMID:35447139 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Odc1 |
ornithine decarboxylase 1 |
decreases expression |
ISO |
cinobufagin results in decreased expression of ODC1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression multiple interactions |
ISO |
cinobufagin results in increased expression of PARP1 protein modified form GSK3B protein mutant form inhibits the reaction [cinobufagin results in increased expression of PARP1 protein modified form]; SB 216763 promotes the reaction [cinobufagin results in increased expression of PARP1 protein modified form] |
CTD |
PMID:23164673 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
cinobufagin results in decreased expression of PCNA mRNA; cinobufagin results in decreased expression of PCNA protein |
CTD |
PMID:21215801 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression multiple interactions |
ISO |
cinobufagin results in decreased expression of RELA protein GSK3B protein mutant form inhibits the reaction [cinobufagin results in decreased expression of RELA protein]; SB 216763 promotes the reaction [cinobufagin results in decreased expression of RELA protein] |
CTD |
PMID:23164673 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rpl6 |
ribosomal protein L6 |
decreases expression |
ISO |
cinobufagin results in decreased expression of RPL6 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
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G |
Rrp9 |
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein |
decreases expression |
ISO |
cinobufagin results in decreased expression of RRP9 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 8:107,116,411...107,126,123
Ensembl chr 8:107,117,471...107,126,123
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G |
Runx1 |
RUNX family transcription factor 1 |
increases expression |
ISO |
cinobufagin results in increased expression of RUNX1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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G |
Sat1 |
spermidine/spermine N1-acetyl transferase 1 |
increases expression |
ISO |
cinobufagin results in increased expression of SAT1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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G |
Tfb2m |
transcription factor B2, mitochondrial |
decreases expression |
ISO |
cinobufagin results in decreased expression of TFB2M mRNA |
CTD |
PMID:35447139 |
|
NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
cinobufagin results in increased expression of TGFB1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
increases expression |
ISO |
cinobufagin results in increased expression of TGFBR1 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
cinobufagin results in increased expression of TIMP2 mRNA |
CTD |
PMID:35447139 |
|
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
cinobufagin results in increased expression of TNF mRNA |
CTD |
PMID:35447139 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Txnip |
thioredoxin interacting protein |
increases expression |
ISO |
cinobufagin results in increased expression of TXNIP mRNA |
CTD |
PMID:35447139 |
|
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Tyms |
thymidylate synthetase |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cinobufagin results in decreased expression of TYMS protein]; cinobufagin promotes the reaction [Cycloheximide results in decreased expression of TYMS protein] |
CTD |
PMID:35427566 |
|
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
cinobufagin results in decreased expression of XIAP protein |
CTD |
PMID:23164673 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
cinobufotalin results in decreased phosphorylation of AKT1 protein MIR2110 affects the reaction [cinobufotalin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:38477013 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases activity |
ISO |
cinobufotalin results in increased activity of BAX protein |
CTD |
PMID:22898211 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bid |
BH3 interacting domain death agonist |
increases activity |
ISO |
cinobufotalin results in increased activity of BID protein |
CTD |
PMID:22898211 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Casp2 |
caspase 2 |
increases cleavage |
ISO |
cinobufotalin results in increased cleavage of CASP2 protein |
CTD |
PMID:22898211 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
cinobufotalin results in increased cleavage of CASP3 protein |
CTD |
PMID:22898211 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
cinobufotalin results in increased cleavage of CASP8 protein |
CTD |
PMID:22898211 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
cinobufotalin results in increased cleavage of CASP9 protein |
CTD |
PMID:22898211 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
cinobufotalin results in increased expression of FAS protein |
CTD |
PMID:22898211 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
cinobufotalin results in decreased expression of JUN protein |
CTD |
PMID:38477013 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Cymarine inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] |
CTD |
PMID:23104431 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
Digitoxigenin results in decreased expression of CCL2 protein |
CTD |
PMID:20116850 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
decreases expression |
ISO |
Digitoxigenin results in decreased expression of CCL4 protein |
CTD |
PMID:20116850 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
ISO |
Digitoxigenin results in decreased expression of CCL5 protein |
CTD |
PMID:20116850 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Il6r |
interleukin 6 receptor |
decreases expression |
ISO |
Digitoxigenin results in decreased expression of IL6R protein modified form |
CTD |
PMID:20116850 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Digitoxigenin results in decreased expression of VEGFA protein |
CTD |
PMID:20116850 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases transport |
ISO |
Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] ABCB1 protein results in increased transport of Digitoxin |
CTD |
PMID:23104431 PMID:26708294 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Digitoxin binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein |
CTD |
PMID:22037315 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
decreases expression multiple interactions |
ISO |
Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]] |
CTD |
PMID:22037315 PMID:34717917 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage multiple interactions |
ISO |
Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]] |
CTD |
PMID:22037315 PMID:34717917 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein |
CTD |
PMID:22037315 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] |
CTD |
PMID:19446813 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnb1 |
cyclin B1 |
multiple interactions decreases expression |
ISO |
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein] Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein |
CTD |
PMID:22037315 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]] Digitoxin results in decreased expression of CCND1 protein |
CTD |
PMID:34717917 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression multiple interactions |
ISO |
Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein] |
CTD |
PMID:22037315 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein |
CTD |
PMID:22037315 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein |
CTD |
PMID:22037315 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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|
G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein |
CTD |
PMID:22037315 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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|
G |
Chek2 |
checkpoint kinase 2 |
decreases expression |
ISO |
Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein |
CTD |
PMID:22037315 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein |
CTD |
PMID:22037315 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases phosphorylation |
ISO |
Digitoxin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF4EBP1 protein] Digitoxin results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:34717917 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Digitoxin binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
Digitoxin binds to and results in decreased activity of ESR2 protein |
CTD |
PMID:25752796 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions |
ISO |
Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] |
CTD |
PMID:24124520 |
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NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fanci |
FA complementation group I |
multiple interactions |
ISO |
Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] |
CTD |
PMID:24124520 |
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NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Digitoxin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]] |
CTD |
PMID:34717917 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] |
CTD |
PMID:19446813 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] |
CTD |
PMID:19446813 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] |
CTD |
PMID:19446813 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] |
CTD |
PMID:19446813 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
decreases phosphorylation |
ISO |
Digitoxin results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:15136726 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases activity |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] |
CTD |
PMID:19446813 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
Digitoxin binds to and results in decreased activity of PGR protein |
CTD |
PMID:25752796 |
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Pias3 |
protein inhibitor of activated STAT, 3 |
increases expression |
ISO |
Digitoxin results in increased expression of PIAS3 protein |
CTD |
PMID:34717917 |
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NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
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G |
Pten |
phosphatase and tensin homolog |
increases expression |
ISO |
Digitoxin results in increased expression of PTEN protein |
CTD |
PMID:34717917 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptpn6 |
protein tyrosine phosphatase, non-receptor type 6 |
increases expression |
ISO |
Digitoxin results in increased expression of PTPN6 protein |
CTD |
PMID:34717917 |
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NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation multiple interactions |
ISO |
Digitoxin results in decreased phosphorylation of RPS6KB1 protein [Digitoxin co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:34717917 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[Digitoxin co-treated with Oxygen deficiency] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]; Digitoxin results in decreased expression of and results in decreased phosphorylation of STAT3 protein; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP3 protein]]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; HIF1A protein affects the reaction [Digitoxin promotes the reaction [STAT3 protein affects the expression of CCND1 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin promotes the reaction [HIF1A protein affects the expression of CCND1 protein]] |
CTD |
PMID:34717917 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Digitoxin binds to and results in decreased activity of THRA protein |
CTD |
PMID:25752796 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions |
ISO |
Digitoxin binds to and results in decreased activity of THRB protein |
CTD |
PMID:25752796 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Tp53 |
tumor protein p53 |
decreases expression |
ISO |
Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein |
CTD |
PMID:22037315 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] |
CTD |
PMID:19446813 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport |
ISO |
ABCB1 protein results in increased transport of Digoxigenin |
CTD |
PMID:26708294 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
Digoxigenin results in decreased expression of CCL2 protein |
CTD |
PMID:20116850 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
decreases expression |
ISO |
Digoxigenin results in decreased expression of CCL4 protein |
CTD |
PMID:20116850 |
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NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions increases expression |
ISO |
Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter] Digoxigenin results in increased expression of G6PC1 mRNA |
CTD |
PMID:29981919 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Digoxigenin results in increased expression of and results in increased secretion of IL17A protein |
CTD |
PMID:29981919 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17f |
interleukin 17F |
multiple interactions |
ISO |
Digoxigenin results in increased expression of and results in increased secretion of IL17F protein |
CTD |
PMID:29981919 |
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NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
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G |
Il6r |
interleukin 6 receptor |
decreases expression |
ISO |
Digoxigenin results in decreased expression of IL6R protein modified form |
CTD |
PMID:20116850 |
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NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Npas2 |
neuronal PAS domain protein 2 |
increases expression multiple interactions |
ISO |
Digoxigenin results in increased expression of NPAS2 mRNA Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
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NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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G |
Rorc |
RAR-related orphan receptor C |
increases expression multiple interactions |
ISO |
Digoxigenin results in increased expression of RORC mRNA Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA] |
CTD |
PMID:29981919 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Digoxigenin results in decreased expression of VEGFA protein |
CTD |
PMID:20116850 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Abca8 |
ATP binding cassette subfamily A member 8 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:12379217 |
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NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects abundance affects uptake increases uptake multiple interactions increases export increases transport affects secretion increases expression affects binding decreases uptake affects transport |
ISO EXP |
ABCB1 gene SNP affects the abundance of Digoxin ABCB1A protein affects the uptake of Digoxin ABCB1 protein results in increased uptake of Digoxin 18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Plant Extracts results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; ABCB1 protein binds to and affects the metabolism of Digoxin; abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; cyazofamid affects the reaction [ABCB1 protein results in increased uptake of Digoxin]; dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]; gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] [P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Digoxin; Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin] ABCB1A protein results in increased uptake of Digoxin ABCB1 protein affects the secretion of Digoxin Digoxin results in increased expression of ABCB1 mRNA; Digoxin results in increased expression of ABCB1 protein Digoxin binds to ABCB1 protein ABCB1 protein results in decreased uptake of Digoxin ABCB1 gene SNP affects the transport of Digoxin; ABCB1 protein affects the transport of Digoxin |
CTD |
PMID:10527640 PMID:10562306 PMID:10617675 PMID:10997946 PMID:11231118 PMID:11895100 PMID:15276087 PMID:15856409 PMID:15890377 PMID:15969931 PMID:16221533 PMID:16671962 PMID:16674925 PMID:16904803 PMID:17365992 PMID:18385293 PMID:19505989 PMID:19647009 PMID:19958760 PMID:21240898 PMID:21311904 PMID:21321059 PMID:21341280 PMID:23104431 PMID:23976943 PMID:24380838 PMID:25844889 PMID:26888941 PMID:30790579 PMID:31756430 PMID:32003934 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
affects uptake |
ISO |
ABCB1B protein affects the uptake of Digoxin |
CTD |
PMID:10562306 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases activity |
ISO |
Digoxin results in decreased activity of ABCG2 protein |
CTD |
PMID:15365089 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of ALPL protein] |
CTD |
PMID:36329302 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
decreases expression multiple interactions |
EXP |
Digoxin results in decreased expression of ATP1A2 mRNA N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA] |
CTD |
PMID:19687166 |
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NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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G |
Atp1a3 |
ATPase Na+/K+ transporting subunit alpha 3 |
decreases expression multiple interactions |
EXP |
Digoxin results in decreased expression of ATP1A3 mRNA N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A3 mRNA] |
CTD |
PMID:19687166 |
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NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
Digoxin results in decreased expression of CCL2 protein |
CTD |
PMID:20116850 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
decreases expression |
ISO |
Digoxin results in decreased expression of CCL4 protein |
CTD |
PMID:20116850 |
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NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
ISO |
Digoxin results in decreased expression of CCL5 protein |
CTD |
PMID:20116850 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 protein] |
CTD |
PMID:36329302 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 protein] |
CTD |
PMID:36329302 |
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NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein] |
CTD |
PMID:36329302 |
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NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 protein] |
CTD |
PMID:36329302 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] |
CTD |
PMID:24124520 |
|
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fanci |
FA complementation group I |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] |
CTD |
PMID:24124520 |
|
NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity |
EXP |
Digoxin results in decreased activity of G6PD protein |
CTD |
PMID:26820767 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gfap |
glial fibrillary acidic protein |
increases expression |
EXP |
Digoxin results in increased expression of GFAP mRNA |
CTD |
PMID:22954530 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein] |
CTD |
PMID:36329302 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GPT protein] |
CTD |
PMID:36329302 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
EXP |
Digoxin results in decreased activity of GSR protein |
CTD |
PMID:26820767 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases activity affects localization |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein]; Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein; KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein] Digoxin results in increased activity of HIF1A protein |
CTD |
PMID:19647009 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of ICAM1 mRNA] |
CTD |
PMID:36329302 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA |
CTD |
PMID:29594315 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]; Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A protein] |
CTD |
PMID:22292739 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
[Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA |
CTD |
PMID:29594315 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
|
|
G |
Il23r |
interleukin 23 receptor |
multiple interactions |
ISO |
Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL23R mRNA] |
CTD |
PMID:22292739 |
|
NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021
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G |
Il6r |
interleukin 6 receptor |
decreases expression |
ISO |
Digoxin results in decreased expression of IL6R protein modified form |
CTD |
PMID:20116850 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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|
G |
Ins2 |
insulin 2 |
decreases response to substance |
ISO EXP |
INS protein results in decreased susceptibility to Digoxin |
CTD |
PMID:22562035 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions affects response to substance decreases expression decreases activity |
ISO |
Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein] KCNH2 gene affects the susceptibility to Digoxin Digoxin results in decreased expression of KCNH2 protein modified form |
CTD |
PMID:19139152 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
|
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:19687166 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
EXP |
Digoxin results in increased phosphorylation of MAPK3 protein N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:19687166 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nos3 |
nitric oxide synthase 3 |
decreases response to substance |
ISO |
NOS3 protein results in decreased susceptibility to Digoxin |
CTD |
PMID:11761419 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppa |
natriuretic peptide A |
multiple interactions increases expression |
EXP |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA] |
CTD |
PMID:19687166 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
increases expression |
ISO |
Digoxin results in increased expression of NPPB protein |
CTD |
PMID:16032632 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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|
G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] |
CTD |
PMID:25257666 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Pgd |
phosphogluconate dehydrogenase |
decreases activity |
EXP |
Digoxin results in decreased activity of PGD protein |
CTD |
PMID:26820767 |
|
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Rorc |
RAR-related orphan receptor C |
decreases activity multiple interactions |
ISO |
Digoxin results in decreased activity of RORC protein Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC protein] |
CTD |
PMID:21441909 PMID:36329302 |
|
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
|
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc9a1 |
solute carrier family 9 member A1 |
increases expression multiple interactions |
EXP |
Digoxin results in increased expression of SLC9A1 mRNA N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA] |
CTD |
PMID:19687166 |
|
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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|
G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions increases uptake decreases activity affects transport |
ISO EXP |
Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite]; Elacridar affects the reaction [SLCO1A4 protein affects the transport of Digoxin] SLCO1A4 protein results in increased uptake of Digoxin Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin] Digoxin results in decreased activity of SLCO1A4 protein |
CTD |
PMID:11883641 PMID:19833843 PMID:34619012 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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|
G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
Digoxin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1B2 mRNA] |
CTD |
PMID:36329302 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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|
G |
Tardbp |
TAR DNA binding protein |
multiple interactions |
ISO |
Digoxin inhibits the reaction [TARDBP protein binds to TARDBP protein] |
CTD |
PMID:23891805 |
|
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Digoxin results in decreased expression of VEGFA protein |
CTD |
PMID:20116850 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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|
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions increases expression |
ISO |
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter] dihydroouabain results in increased expression of G6PC1 mRNA |
CTD |
PMID:29981919 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
dihydroouabain results in increased expression of and results in increased secretion of IL17A protein |
CTD |
PMID:29981919 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
|
|
G |
Il17f |
interleukin 17F |
multiple interactions |
ISO |
dihydroouabain results in increased expression of and results in increased secretion of IL17F protein |
CTD |
PMID:29981919 |
|
NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
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G |
Npas2 |
neuronal PAS domain protein 2 |
increases expression multiple interactions |
ISO |
dihydroouabain results in increased expression of NPAS2 mRNA dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
|
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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G |
Rorc |
RAR-related orphan receptor C |
multiple interactions increases expression |
ISO |
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA] |
CTD |
PMID:29981919 |
|
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
drospirenone results in decreased activity of ABCB11 protein |
CTD |
PMID:23956101 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Ar |
androgen receptor |
multiple interactions affects localization |
ISO |
drospirenone binds to and results in increased activity of AR protein drospirenone affects the localization of AR protein |
CTD |
PMID:28478275 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein |
CTD |
PMID:17418832 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
|
|
G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
multiple interactions |
ISO |
drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] |
CTD |
PMID:28257955 |
|
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of HSPD1 mRNA |
CTD |
PMID:19631796 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with drospirenone] results in decreased expression of NOS2 mRNA |
CTD |
PMID:19631796 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
affects binding |
EXP |
drospirenone binds to NR3C2 protein |
CTD |
PMID:1493716 PMID:14667981 |
|
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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G |
Pgr |
progesterone receptor |
affects binding |
ISO |
drospirenone binds to PGR protein |
CTD |
PMID:14667981 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Serpina6 |
serpin family A member 6 |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SERPINA6 protein |
CTD |
PMID:11245553 |
|
NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349
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G |
Shbg |
sex hormone binding globulin |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein |
CTD |
PMID:11245553 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein |
CTD |
PMID:24954031 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation |
ISO |
hellebrigenin results in increased phosphorylation of ATM protein |
CTD |
PMID:24954031 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
|
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects localization |
ISO |
hellebrigenin affects the localization of BAX protein |
CTD |
PMID:24954031 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
hellebrigenin results in increased expression of CCNB1 protein |
CTD |
PMID:24954031 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Cdc25c |
cell division cycle 25C |
decreases phosphorylation |
ISO |
hellebrigenin results in decreased phosphorylation of CDC25C protein |
CTD |
PMID:24954031 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases phosphorylation |
ISO |
hellebrigenin results in increased phosphorylation of CDK1 protein |
CTD |
PMID:24954031 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
|
|
G |
Chek2 |
checkpoint kinase 2 |
increases phosphorylation |
ISO |
hellebrigenin results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:24954031 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases activity |
ISO |
hellebrigenin results in increased activity of PARP1 protein |
CTD |
PMID:24954031 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
|
G |
Rorc |
RAR-related orphan receptor C |
increases expression |
ISO |
helveticoside results in increased expression of RORC mRNA |
CTD |
PMID:29981919 |
|
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
|
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
lanatoside C results in decreased expression of CCL2 protein |
CTD |
PMID:20116850 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
decreases expression |
ISO |
lanatoside C results in decreased expression of CCL4 protein |
CTD |
PMID:20116850 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
ISO |
lanatoside C results in decreased expression of CCL5 protein |
CTD |
PMID:20116850 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Il6r |
interleukin 6 receptor |
decreases expression |
ISO |
lanatoside C results in decreased expression of IL6R protein modified form |
CTD |
PMID:20116850 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
|
|
G |
Tardbp |
TAR DNA binding protein |
multiple interactions |
ISO |
lanatoside C inhibits the reaction [TARDBP protein binds to TARDBP protein] |
CTD |
PMID:23891805 |
|
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
|
|
G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
lanatoside C results in decreased expression of VEGFA protein |
CTD |
PMID:20116850 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression |
EXP |
marinobufagenin results in increased expression of COL1A1 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Mir101a |
microRNA 101a |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR101A mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410
|
|
G |
Mir106b |
microRNA 106b |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR106B mRNA |
CTD |
PMID:26702050 |
|
NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
|
|
G |
Mir122 |
microRNA 122 |
increases expression |
EXP |
marinobufagenin results in increased expression of MIR122 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr18:58,758,703...58,758,787
|
|
G |
Mir130a |
microRNA 130a |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR130A mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
|
|
G |
Mir140 |
microRNA 140 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR140 mRNA |
CTD |
PMID:26702050 |
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NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
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G |
Mir141 |
microRNA 141 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR141 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
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G |
Mir142 |
microRNA 142 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR142 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
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G |
Mir144 |
microRNA 144 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR144 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
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G |
Mir185 |
microRNA 185 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR185 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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G |
Mir18a |
microRNA 18a |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR18A mRNA |
CTD |
PMID:26702050 |
|
NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
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G |
Mir196a |
microRNA 196a |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR196A mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509
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G |
Mir196b |
microRNA 196b |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR196B mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571
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G |
Mir210 |
microRNA 210 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR210 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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G |
Mir222 |
microRNA 222 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR222 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006
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G |
Mir23a |
microRNA 23a |
increases expression |
EXP |
marinobufagenin results in increased expression of MIR23A mRNA |
CTD |
PMID:26702050 |
|
NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
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G |
Mir29b1 |
microRNA 29b-1 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR29B1 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
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G |
Mir32 |
microRNA 32 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR32 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152
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G |
Mir320a |
microRNA 320a |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR320A mRNA |
CTD |
PMID:26702050 |
|
NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
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G |
Mir322 |
microRNA 322 |
increases expression |
EXP |
marinobufagenin results in increased expression of MIR322 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr X:132,806,594...132,806,688
Ensembl chr X:132,806,594...132,806,688
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G |
Mir324 |
microRNA 324 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR324 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766
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G |
Mir375 |
microRNA 375 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR375 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
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G |
Mir423 |
microRNA 423 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR423 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
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G |
Mir93 |
microRNA 93 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR93 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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G |
Mir96 |
microRNA 96 |
decreases expression |
EXP |
marinobufagenin results in decreased expression of MIR96 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
oleandrin results in increased activity of CASP3 protein |
CTD |
PMID:24172227 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
oleandrin results in increased activity of CASP8 protein |
CTD |
PMID:24172227 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
increases expression |
ISO |
oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein |
CTD |
PMID:24172227 |
|
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
increases expression |
ISO |
oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein |
CTD |
PMID:24172227 |
|
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
ISO |
oleandrin results in increased expression of CXCR4 mRNA |
CTD |
PMID:24172227 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
A2m |
alpha-2-macroglobulin |
affects expression |
ISO |
Ouabain affects the expression of A2M protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases expression |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein |
CTD |
PMID:19647009 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acaa2 |
acetyl-CoA acyltransferase 2 |
affects expression |
ISO |
Ouabain affects the expression of ACAA2 protein |
CTD |
PMID:17268060 |
|
NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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G |
Ace |
angiotensin I converting enzyme |
affects expression |
EXP |
Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein |
CTD |
PMID:16565308 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Acta2 |
actin alpha 2, smooth muscle |
affects expression |
ISO |
Ouabain affects the expression of ACTA2 protein |
CTD |
PMID:17268060 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
affects expression |
ISO |
Ouabain affects the expression of ADH1C protein |
CTD |
PMID:17268060 |
|
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Agt |
angiotensinogen |
affects expression increases expression |
EXP |
Ouabain affects the expression of AGT protein Ouabain results in increased expression of AGT protein |
CTD |
PMID:11768735 PMID:16565308 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression affects expression |
EXP |
Ouabain results in decreased expression of AGTR1A protein Ouabain affects the expression of AGTR1A mRNA |
CTD |
PMID:16565308 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
ISO |
Ouabain results in increased expression of AIFM1 protein |
CTD |
PMID:31436044 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Anxa1 |
annexin A1 |
affects expression |
ISO |
Ouabain affects the expression of ANXA1 protein |
CTD |
PMID:17268060 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa2 |
annexin A2 |
affects expression |
ISO |
Ouabain affects the expression of ANXA2 protein |
CTD |
PMID:17268060 |
|
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
Ouabain results in increased expression of APAF1 protein |
CTD |
PMID:31436044 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Araf |
A-Raf proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of ARAF mRNA |
CTD |
PMID:16412265 |
|
NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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G |
Arih1 |
ariadne RBR E3 ubiquitin protein ligase 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of ARIH1 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
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G |
Arpc5 |
actin related protein 2/3 complex, subunit 5 |
affects expression |
ISO |
Ouabain affects the expression of ARPC5 protein |
CTD |
PMID:17268060 |
|
NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410
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G |
Arrb1 |
arrestin, beta 1 |
increases expression |
ISO |
Ouabain results in increased expression of ARRB1 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
affects expression |
ISO |
Ouabain affects the expression of ASAH1 protein |
CTD |
PMID:17268060 |
|
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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G |
Atf6b |
activating transcription factor 6 beta |
increases expression |
ISO |
Ouabain results in increased expression of ATF6B protein |
CTD |
PMID:31436044 |
|
NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
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G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation |
ISO |
Ouabain results in increased phosphorylation of ATM protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp12a |
ATPase H+/K+ transporting non-gastric alpha2 subunit |
multiple interactions |
ISO |
Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] |
CTD |
PMID:8853415 |
|
NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229
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G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
multiple interactions increases expression affects expression affects binding |
ISO EXP |
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein] Ouabain affects the expression of ATP1A1 protein Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein Ouabain binds to ATP1A1 protein |
CTD |
PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221 |
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NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
multiple interactions increases expression decreases expression affects expression decreases activity affects response to substance affects binding |
ISO EXP |
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] Ouabain results in increased expression of ATP1A2 protein Ouabain results in decreased expression of ATP1A2 mRNA Ouabain affects the expression of ATP1A2 protein N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA] Ouabain results in decreased activity of ATP1A2 protein Ouabain binds to and results in decreased activity of ATP1A2 protein ATP1A2 protein affects the susceptibility to Ouabain Ouabain binds to ATP1A2 protein |
CTD |
PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 PMID:18487447 PMID:19687166 PMID:19897708 PMID:19995221 More...
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NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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G |
Atp1a3 |
ATPase Na+/K+ transporting subunit alpha 3 |
increases expression multiple interactions decreases expression affects expression affects binding |
ISO EXP |
Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain] Ouabain results in decreased expression of ATP1A3 mRNA Ouabain affects the expression of ATP1A3 protein N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA] ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein |
CTD |
PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 PMID:24631656 More...
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NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
multiple interactions increases expression |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] |
CTD |
PMID:11204457 |
|
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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G |
Atp4b |
ATPase H+/K+ transporting subunit beta |
multiple interactions |
ISO |
Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] |
CTD |
PMID:8853415 |
|
NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
affects expression |
ISO |
Ouabain affects the expression of ATP5F1A protein |
CTD |
PMID:17268060 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atr |
ATR serine/threonine kinase |
decreases phosphorylation |
ISO |
Ouabain results in decreased phosphorylation of ATR protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Bahd1 |
bromo adjacent homology domain containing 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of BAHD1 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects localization increases expression multiple interactions |
ISO |
Ouabain affects the localization of BAX protein Ouabain results in increased expression of BAX protein Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein] |
CTD |
PMID:17096883 PMID:18247327 PMID:31436044 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Ouabain results in decreased expression of BCL2 protein |
CTD |
PMID:31436044 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of BCL2L1 protein |
CTD |
PMID:31436044 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions decreases expression |
EXP |
Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] |
CTD |
PMID:19954800 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression |
ISO |
Ouabain results in decreased expression of BRCA1 protein |
CTD |
PMID:31436044 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Calb1 |
calbindin 1 |
decreases expression |
EXP |
Ouabain results in decreased expression of CALB1 protein |
CTD |
PMID:20105455 |
|
NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Calml5 |
calmodulin-like 5 |
affects expression |
ISO |
Ouabain affects the expression of CALML5 protein |
CTD |
PMID:17268060 |
|
NCBI chr17:66,394,433...66,395,352
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|
G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
increases expression |
ISO |
Ouabain results in increased expression of CAMK2B protein |
CTD |
PMID:31436044 |
|
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Canx |
calnexin |
increases expression |
ISO |
Ouabain results in increased expression of CANX protein |
CTD |
PMID:18247327 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions increases activity |
ISO EXP |
Ouabain results in increased expression of CASP3 protein Ouabain results in increased activity of and results in increased cleavage of CASP3 protein Ouabain results in increased activity of CASP3 protein |
CTD |
PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases expression |
ISO |
Ouabain results in increased expression of CASP4 protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Ouabain results in increased expression of and results in increased activity of CASP8 protein |
CTD |
PMID:31436044 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Ouabain results in increased expression of and results in increased activity of CASP9 protein |
CTD |
PMID:31436044 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity |
EXP |
Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] |
CTD |
PMID:20627318 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CAV1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccdc14 |
coiled-coil domain containing 14 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCDC14 mRNA |
CTD |
PMID:16412265 |
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NCBI chr11:66,052,063...66,087,915
Ensembl chr11:66,052,620...66,087,956
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein] Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein |
CTD |
PMID:11340305 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCNA1 mRNA |
CTD |
PMID:20460749 |
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NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCNA2 mRNA |
CTD |
PMID:21215801 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCND1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
decreases expression increases expression |
ISO |
Ouabain results in decreased expression of CDH1 protein Ouabain results in increased expression of CDH1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein |
CTD |
PMID:28795476 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein |
CTD |
PMID:20460749 PMID:21215801 PMID:31436044 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
Ouabain results in decreased expression of CDK6 protein |
CTD |
PMID:31436044 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression increases expression |
ISO |
Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein |
CTD |
PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ckb |
creatine kinase B |
decreases activity |
EXP |
Ouabain results in decreased activity of CKB protein |
CTD |
PMID:19911114 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Cldn1 |
claudin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CLDN1 protein |
CTD |
PMID:18247327 |
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NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Cnpy2 |
canopy FGF signaling regulator 2 |
affects expression |
ISO |
Ouabain affects the expression of CNPY2 protein |
CTD |
PMID:17268060 |
|
NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
EXP |
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] |
CTD |
PMID:26702050 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Cs |
citrate synthase |
decreases activity |
EXP |
Ouabain results in decreased activity of CS protein |
CTD |
PMID:20372980 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Cyc1 |
cytochrome c-1 |
multiple interactions |
ISO |
Ouabain results in decreased expression of and affects the localization of CYC1 protein |
CTD |
PMID:18247327 |
|
NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Ouabain results in increased expression of DDIT3 protein |
CTD |
PMID:31436044 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
decreases expression |
ISO |
Ouabain results in decreased expression of DDOST mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
increases expression |
ISO |
Ouabain results in increased expression of DNAJA3 mRNA |
CTD |
PMID:28795476 |
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NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions decreases expression |
ISO EXP |
Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein Ouabain results in decreased expression of DRD1 mRNA |
CTD |
PMID:19626329 PMID:20132239 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Dsg1 |
desmoglein 1 |
affects expression |
ISO |
Ouabain affects the expression of DSG1 protein |
CTD |
PMID:17268060 |
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NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443
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G |
Dut |
deoxyuridine triphosphatase |
affects expression |
ISO |
Ouabain affects the expression of DUT protein |
CTD |
PMID:17268060 |
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NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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G |
Ece1 |
endothelin converting enzyme 1 |
increases expression |
ISO |
Ouabain results in increased expression of ECE1 protein |
CTD |
PMID:18247327 |
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NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
affects expression |
ISO |
Ouabain affects the expression of ECHS1 protein |
CTD |
PMID:17268060 |
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NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Edn1 |
endothelin 1 |
increases expression decreases expression |
EXP ISO |
Ouabain results in increased expression of EDN1 mRNA Ouabain results in decreased expression of EDN1 mRNA |
CTD |
PMID:15477225 PMID:28795476 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Ednra |
endothelin receptor type A |
increases expression |
EXP |
Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein |
CTD |
PMID:15477225 PMID:16982439 |
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NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
Ouabain results in decreased phosphorylation of EGFR protein |
CTD |
PMID:28795476 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases expression |
ISO |
Ouabain results in increased expression of EIF2A protein |
CTD |
PMID:31436044 |
|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:31436044 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif3k |
eukaryotic translation initiation factor 3, subunit K |
affects expression |
ISO |
Ouabain affects the expression of EIF3K protein |
CTD |
PMID:17268060 |
|
NCBI chr 1:84,260,127...84,270,051
Ensembl chr 1:84,259,673...84,270,302
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G |
Endog |
endonuclease G |
increases expression |
ISO |
Ouabain results in increased expression of ENDOG protein |
CTD |
PMID:31436044 |
|
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Ercc4 |
ERCC excision repair 4, endonuclease catalytic subunit |
decreases expression |
ISO |
Ouabain results in decreased expression of ERCC4 mRNA |
CTD |
PMID:24124520 |
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NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
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G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
decreases expression |
ISO |
Ouabain results in decreased expression of ETS1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
Ouabain results in increased expression of FADD protein |
CTD |
PMID:31436044 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions decreases expression |
ISO |
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]] Ouabain results in decreased expression of FANCD2 mRNA |
CTD |
PMID:24124520 |
|
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fancf |
FA complementation group F |
decreases expression |
ISO |
Ouabain results in decreased expression of FANCF mRNA |
CTD |
PMID:24124520 |
|
NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923
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G |
Fanci |
FA complementation group I |
decreases expression multiple interactions |
ISO |
Ouabain results in decreased expression of FANCI mRNA Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] |
CTD |
PMID:24124520 |
|
NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Fars2 |
phenylalanyl-tRNA synthetase 2, mitochondrial |
increases expression |
ISO |
Ouabain results in increased expression of FARS2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Ouabain results in increased expression of FAS protein |
CTD |
PMID:31436044 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
ISO |
Ouabain results in increased expression of FASLG protein |
CTD |
PMID:31436044 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fbxo32 |
F-box protein 32 |
multiple interactions |
ISO |
Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] |
CTD |
PMID:21139329 |
|
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fh |
fumarate hydratase |
affects expression |
ISO |
Ouabain affects the expression of FH protein |
CTD |
PMID:17268060 |
|
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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G |
Fkbp7 |
FKBP prolyl isomerase 7 |
increases expression |
ISO |
Ouabain results in increased expression of FKBP7 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280
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G |
Fn1 |
fibronectin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of FN1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Gc |
GC, vitamin D binding protein |
affects expression |
ISO |
Ouabain affects the expression of GC protein |
CTD |
PMID:17268060 |
|
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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G |
Glrb |
glycine receptor, beta |
increases expression |
ISO |
Ouabain results in increased expression of GLRB mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489
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G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of GRB2 protein |
CTD |
PMID:28795476 |
|
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Gtpbp6 |
GTP binding protein 6 (putative) |
increases expression |
ISO |
Ouabain results in increased expression of GTPBP6 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation |
ISO |
Ouabain results in increased phosphorylation of H2AX protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
increases expression |
ISO |
Ouabain results in increased expression of HEY1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
EXP |
Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:18031729 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions affects localization increases activity |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein Ouabain results in increased activity of HIF1A protein |
CTD |
PMID:19647009 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hnrnpa2b1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
affects expression |
ISO |
Ouabain affects the expression of HNRNPA2B1 protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
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G |
Hnrnpdl |
heterogeneous nuclear ribonucleoprotein D-like |
decreases expression |
ISO |
Ouabain results in decreased expression of HNRNPDL mRNA |
CTD |
PMID:16412265 |
|
NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
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G |
Hpcal1 |
hippocalcin-like 1 |
affects expression |
ISO |
Ouabain affects the expression of HPCAL1 protein |
CTD |
PMID:17268060 |
|
NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687
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G |
Hrg |
histidine-rich glycoprotein |
affects expression |
ISO |
Ouabain affects the expression of HRG protein |
CTD |
PMID:17268060 |
|
NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Ouabain results in increased expression of HSPA5 protein |
CTD |
PMID:31436044 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
affects expression multiple interactions |
ISO |
Ouabain affects the expression of HSPD1 protein Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein |
CTD |
PMID:17268060 PMID:18247327 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
ISO |
Ouabain results in increased expression of ID2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
decreases expression |
ISO |
Ouabain results in decreased expression of IL2RA mRNA |
CTD |
PMID:7593202 |
|
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il2rb |
interleukin 2 receptor subunit beta |
decreases expression |
ISO |
Ouabain results in decreased expression of IL2RB |
CTD |
PMID:7593202 |
|
NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
|
|
G |
Il6 |
interleukin 6 |
increases secretion increases expression |
ISO |
Ouabain results in increased secretion of IL6 protein Ouabain results in increased expression of IL6 mRNA |
CTD |
PMID:33760381 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Il6r |
interleukin 6 receptor |
increases expression |
ISO |
Ouabain results in increased expression of IL6R mRNA |
CTD |
PMID:33760381 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
|
|
G |
Ilk |
integrin-linked kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of ILK mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
|
|
G |
Itgav |
integrin subunit alpha V |
decreases expression |
ISO |
Ouabain results in decreased expression of ITGAV mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression decreases phosphorylation |
ISO |
Ouabain results in decreased expression of JUN mRNA Ouabain results in decreased phosphorylation of JUN protein |
CTD |
PMID:28795476 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Kcnd2 |
potassium voltage-gated channel subfamily D member 2 |
increases expression |
ISO EXP |
Ouabain results in increased expression of KCND2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases expression decreases activity multiple interactions |
ISO |
Ouabain results in decreased expression of KCNH2 protein modified form Ouabain results in decreased activity of KCNH2 protein Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:19139152 PMID:21158687 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
|
|
G |
Lef1 |
lymphoid enhancer binding factor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of LEF1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
|
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G |
Lgals1 |
galectin 1 |
affects expression increases expression |
ISO |
Ouabain affects the expression of LGALS1 protein Ouabain results in increased expression of LGALS1 protein |
CTD |
PMID:17268060 PMID:18247327 |
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NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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G |
Limk1 |
LIM domain kinase 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of LIMK1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606
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G |
Lss |
lanosterol synthase |
increases abundance |
ISO |
LSS protein results in increased abundance of Ouabain |
CTD |
PMID:21106941 |
|
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
increases expression |
ISO |
Ouabain results in increased expression of MAP2K6 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein] Ouabain results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:19687166 PMID:28795476 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein] Ouabain results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:19687166 PMID:28795476 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk7 |
mitogen-activated protein kinase 7 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] |
CTD |
PMID:19716839 |
|
NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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G |
Mdh2 |
malate dehydrogenase 2 |
affects expression |
ISO |
Ouabain affects the expression of MDH2 protein |
CTD |
PMID:17268060 |
|
NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
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G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
ISO |
Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein |
CTD |
PMID:31436044 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases expression |
ISO |
Ouabain results in decreased expression of MGMT protein |
CTD |
PMID:31436044 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mir29b1 |
microRNA 29b-1 |
multiple interactions decreases expression |
EXP |
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] Ouabain results in decreased expression of MIR29B1 mRNA |
CTD |
PMID:26702050 |
|
NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
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G |
Mmp13 |
matrix metallopeptidase 13 |
decreases expression |
ISO |
Ouabain results in decreased expression of MMP13 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions |
ISO |
Ouabain results in decreased expression of MMP2 mRNA Ouabain results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:28795476 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein |
CTD |
PMID:28795476 PMID:33760381 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mras |
muscle RAS oncogene homolog |
decreases expression |
ISO |
Ouabain results in decreased expression of MRAS mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
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G |
Mrtfa |
myocardin related transcription factor A |
decreases expression |
ISO |
Ouabain results in decreased expression of MRTFA mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 7:112,544,305...112,714,418
Ensembl chr 7:112,544,312...112,714,418
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression increases expression |
ISO |
Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein Ouabain results in increased expression of MYC protein |
CTD |
PMID:9653513 PMID:21215801 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myl12a |
myosin light chain 12A |
increases expression |
ISO |
Ouabain results in increased expression of MYL12A protein |
CTD |
PMID:17268060 |
|
NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
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G |
Mylk |
myosin light chain kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of MYLK mRNA |
CTD |
PMID:28795476 |
|
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Nectin3 |
nectin cell adhesion molecule 3 |
decreases expression |
ISO |
Ouabain results in decreased expression of NECTIN3 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519
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G |
Nectin4 |
nectin cell adhesion molecule 4 |
increases expression |
ISO |
Ouabain results in increased expression of NECTIN4 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709
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G |
Nefl |
neurofilament light chain |
decreases expression |
ISO |
Ouabain results in decreased expression of NEFL mRNA |
CTD |
PMID:28795476 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nos1 |
nitric oxide synthase 1 |
affects expression increases expression |
EXP |
Ouabain affects the expression of NOS1 protein Ouabain results in increased expression of NOS1 protein |
CTD |
PMID:12384489 PMID:15097235 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions affects expression increases expression |
EXP |
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein] Ouabain affects the expression of NOS3 protein |
CTD |
PMID:12384489 PMID:15477225 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Npc2 |
NPC intracellular cholesterol transporter 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of NPC2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155
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G |
Nppa |
natriuretic peptide A |
increases expression multiple interactions |
EXP |
Ouabain results in increased expression of NPPA mRNA N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:17266992 PMID:19687166 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nras |
NRAS proto-oncogene, GTPase |
decreases expression |
ISO |
Ouabain results in decreased expression of NRAS mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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G |
Park7 |
Parkinsonism associated deglycase |
affects response to substance |
ISO |
PARK7 affects the susceptibility to Ouabain |
CTD |
PMID:16624565 |
|
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] |
CTD |
PMID:24124520 PMID:31436044 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein |
CTD |
PMID:20460749 PMID:21215801 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Pdcd6 |
programmed cell death 6 |
increases expression |
ISO |
Ouabain results in increased expression of PDCD6 protein |
CTD |
PMID:18247327 |
|
NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189
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G |
Pfdn5 |
prefoldin subunit 5 |
affects expression |
ISO |
Ouabain affects the expression of PFDN5 protein |
CTD |
PMID:17268060 |
|
NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
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|
G |
Pfn1 |
profilin 1 |
affects expression decreases expression |
ISO |
Ouabain affects the expression of PFN1 protein Ouabain results in decreased expression of PFN1 protein |
CTD |
PMID:17268060 PMID:18247327 |
|
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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G |
Plaur |
plasminogen activator, urokinase receptor |
decreases expression |
ISO |
Ouabain results in decreased expression of PLAUR mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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G |
Plcg1 |
phospholipase C, gamma 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of PLCG1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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G |
Ppt2 |
palmitoyl-protein thioesterase 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of PPT2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774
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G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
decreases expression |
ISO |
Ouabain results in decreased expression of PRKDC protein |
CTD |
PMID:31436044 |
|
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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G |
Psmb6 |
proteasome 20S subunit beta 6 |
affects expression |
ISO |
Ouabain affects the expression of PSMB6 protein |
CTD |
PMID:17268060 |
|
NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide |
CTD |
PMID:18976649 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of PTPN2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
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G |
Rab11b |
RAB11B, member RAS oncogene family |
increases expression |
ISO |
Ouabain results in increased expression of RAB11B protein |
CTD |
PMID:18247327 |
|
NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of RAF1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rasgrf1 |
RAS protein-specific guanine nucleotide-releasing factor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of RASGRF1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
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G |
Rgs2 |
regulator of G-protein signaling 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of RGS2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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G |
Rhoh |
ras homolog family member H |
increases expression |
ISO |
Ouabain results in increased expression of RHOH mRNA |
CTD |
PMID:28795476 |
|
NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369
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G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
increases cleavage multiple interactions |
ISO |
Ouabain results in increased cleavage of ROCK1 protein benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein] |
CTD |
PMID:20661774 |
|
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
multiple interactions increases cleavage |
ISO |
benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] |
CTD |
PMID:20661774 |
|
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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|
G |
Rpa3 |
replication protein A3 |
affects expression |
ISO |
Ouabain affects the expression of RPA3 protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
|
|
G |
Rpgrip1l |
Rpgrip1-like |
decreases expression |
ISO |
Ouabain results in decreased expression of RPGRIP1L mRNA |
CTD |
PMID:16412265 |
|
NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083
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|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
affects expression |
EXP |
Ouabain affects the expression of RPS6KB1 mRNA |
CTD |
PMID:28099878 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Ryr2 |
ryanodine receptor 2 |
multiple interactions increases response to substance |
ISO |
K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] |
CTD |
PMID:20080988 |
|
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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|
G |
S100a13 |
S100 calcium binding protein A13 |
affects expression |
ISO |
Ouabain affects the expression of S100A13 protein |
CTD |
PMID:17268060 |
|
NCBI chr 2:175,999,439...176,005,933
|
|
G |
S100b |
S100 calcium binding protein B |
increases expression |
EXP |
Ouabain results in increased expression of S100B protein |
CTD |
PMID:15581912 |
|
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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|
G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions decreases expression |
ISO |
Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium] Ouabain results in decreased expression of SGK1 mRNA |
CTD |
PMID:12590200 PMID:28795476 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] |
CTD |
PMID:12590200 |
|
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
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G |
Sgk3 |
serum/glucocorticoid regulated kinase family, member 3 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] |
CTD |
PMID:12590200 |
|
NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476
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G |
Shc3 |
SHC adaptor protein 3 |
increases expression |
ISO |
Ouabain results in increased expression of SHC3 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710
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|
G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] |
CTD |
PMID:15804185 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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|
G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:15284287 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
|
|
G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] |
CTD |
PMID:12541134 |
|
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
|
|
G |
Slc5a6 |
solute carrier family 5 member 6 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
CTD |
PMID:15561972 |
|
NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
|
|
G |
Slc8a1 |
solute carrier family 8 member A1 |
affects response to substance increases expression multiple interactions |
ISO EXP |
SLC8A1 affects the susceptibility to Ouabain Ouabain results in increased expression of SLC8A1 protein SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein] |
CTD |
PMID:16166162 PMID:19897708 |
|
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
|
|
G |
Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions increases expression |
EXP |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] |
CTD |
PMID:19687166 |
|
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
|
|
G |
Smad4 |
SMAD family member 4 |
decreases expression |
ISO |
Ouabain results in decreased expression of SMAD4 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of SNAI1 mRNA |
CTD |
PMID:33760381 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
|
|
G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of SOS1 protein |
CTD |
PMID:28795476 |
|
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
|
|
G |
Sos2 |
SOS Ras/Rho guanine nucleotide exchange factor 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of SOS2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
|
|
G |
Sphk1 |
sphingosine kinase 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of SPHK1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of TGFB1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tgfb2 |
transforming growth factor, beta 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of TGFB2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tgfb3 |
transforming growth factor, beta 3 |
decreases expression |
ISO |
Ouabain results in decreased expression of TGFB3 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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G |
Tgfbr3 |
transforming growth factor beta receptor 3 |
increases expression |
ISO |
Ouabain results in increased expression of TGFBR3 mRNA |
CTD |
PMID:28795476 |
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NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
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G |
Tln1 |
talin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of TLN1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900
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G |
Tln2 |
talin 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of TLN2 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression |
ISO |
Ouabain results in increased expression of TNFRSF10A protein |
CTD |
PMID:31436044 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein |
CTD |
PMID:31436044 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpi1 |
triosephosphate isomerase 1 |
affects expression |
ISO |
Ouabain affects the expression of TPI1 protein |
CTD |
PMID:17268060 |
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NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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G |
Tpt1 |
tumor protein, translationally-controlled 1 |
affects expression |
ISO |
Ouabain affects the expression of TPT1 protein |
CTD |
PMID:17268060 |
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NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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G |
Trim63 |
tripartite motif containing 63 |
multiple interactions |
ISO |
[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA |
CTD |
PMID:21139329 |
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NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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G |
Trpc1 |
transient receptor potential cation channel, subfamily C, member 1 |
increases expression |
EXP |
Ouabain results in increased expression of TRPC1 protein |
CTD |
PMID:19897708 |
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NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
increases expression multiple interactions |
EXP |
Ouabain results in increased expression of TRPC6 protein SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein] |
CTD |
PMID:19897708 |
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NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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G |
Twist1 |
twist family bHLH transcription factor 1 |
increases expression |
ISO |
Ouabain results in increased expression of TWIST1 mRNA |
CTD |
PMID:33760381 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Txn1 |
thioredoxin 1 |
affects expression |
ISO |
Ouabain affects the expression of TXN protein |
CTD |
PMID:17268060 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Vim |
vimentin |
decreases expression |
ISO |
Ouabain results in decreased expression of VIM mRNA |
CTD |
PMID:33760381 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Zfhx3 |
zinc finger homeobox 3 |
decreases expression |
ISO |
Ouabain results in decreased expression of ZFHX3 mRNA |
CTD |
PMID:16412265 |
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NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
cannogenin thevetoside inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] |
CTD |
PMID:23104431 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity increases metabolic processing |
ISO |
rutaevin results in decreased activity of CYP3A4 protein CYP3A4 protein results in increased metabolism of rutaevin |
CTD |
PMID:33305580 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Spironolactone results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions |
ISO |
Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein] |
CTD |
PMID:21459122 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases expression |
EXP |
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA] Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein |
CTD |
PMID:15652244 PMID:17686906 PMID:19766108 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions increases expression |
ISO EXP |
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA Spironolactone results in increased expression of ABCC3 mRNA [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein |
CTD |
PMID:15833929 PMID:17686906 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
decreases expression |
EXP |
Spironolactone results in decreased expression of ABCG5 mRNA |
CTD |
PMID:15683829 |
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NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Abcg8 |
ATP binding cassette subfamily G member 8 |
decreases expression |
EXP |
Spironolactone results in decreased expression of ABCG8 mRNA |
CTD |
PMID:15683829 |
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NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions decreases expression affects expression |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] Spironolactone results in decreased expression of ACE protein Spironolactone affects the expression of ACE protein |
CTD |
PMID:15932931 PMID:18586661 PMID:30734886 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression affects expression |
EXP |
Spironolactone results in increased expression of ACE2 protein Spironolactone affects the expression of ACE2 protein |
CTD |
PMID:18586661 PMID:30734886 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] |
CTD |
PMID:25204689 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO EXP |
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein] |
CTD |
PMID:29782964 PMID:33359182 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Agt |
angiotensinogen |
decreases expression increases expression multiple interactions |
EXP ISO |
Spironolactone results in decreased expression of AGT protein modified form Spironolactone results in increased expression of AGT protein modified form Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA] |
CTD |
PMID:7357812 PMID:9595286 PMID:19114643 PMID:23288202 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
EXP |
Spironolactone results in decreased expression of AGTR1 protein |
CTD |
PMID:18586661 PMID:19114643 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Agtr2 |
angiotensin II receptor, type 2 |
increases expression |
EXP |
Spironolactone results in increased expression of AGTR2 protein |
CTD |
PMID:18586661 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
Spironolactone results in increased expression of AHR mRNA |
CTD |
PMID:17627975 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH1B1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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G |
Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH4A1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
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G |
Aldh8a1 |
aldehyde dehydrogenase 8 family, member A1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH8A1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] |
CTD |
PMID:29149346 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Aqp2 |
aquaporin 2 |
multiple interactions |
EXP |
[Spironolactone co-treated with Lithium] affects the expression of AQP2 protein |
CTD |
PMID:16159898 |
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NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
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G |
Ar |
androgen receptor |
affects binding multiple interactions |
ISO EXP |
Spironolactone binds to AR protein Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] |
CTD |
PMID:10053169 PMID:14565775 PMID:14751673 PMID:15589981 PMID:18324785 PMID:29162470 PMID:33049310 More...
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bad |
BCL2-associated agonist of cell death |
increases phosphorylation decreases expression |
EXP |
Spironolactone results in increased phosphorylation of BAD protein Spironolactone results in decreased expression of BAD protein |
CTD |
PMID:19114643 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Spironolactone results in increased expression of BCL2 protein |
CTD |
PMID:19114643 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression |
EXP |
Spironolactone results in increased expression of BCL2L1 protein |
CTD |
PMID:19114643 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Becn1 |
beclin 1 |
increases expression |
EXP |
Spironolactone results in increased expression of BECN1 protein |
CTD |
PMID:30734886 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
multiple interactions decreases activity increases activity |
EXP ISO |
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]] Spironolactone results in decreased activity of CASP3 protein Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein] |
CTD |
PMID:19114643 PMID:20609311 PMID:22700542 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]] |
CTD |
PMID:20609311 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]] |
CTD |
PMID:20609311 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein] |
CTD |
PMID:17278980 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] |
CTD |
PMID:18504326 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Ces2c |
carboxylesterase 2C |
increases expression |
ISO |
Spironolactone results in increased expression of CES2C mRNA |
CTD |
PMID:22429928 |
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NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
ISO |
Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form |
CTD |
PMID:9302344 PMID:11300427 PMID:15842549 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cs |
citrate synthase |
multiple interactions |
EXP |
[[Dexamethasone co-treated with Spironolactone] results in increased abundance of Glucocorticoids] which results in increased activity of CS protein |
CTD |
PMID:1328298 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] |
CTD |
PMID:17051331 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Ctf1 |
cardiotrophin 1 |
multiple interactions |
EXP |
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] |
CTD |
PMID:23288202 |
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NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression |
EXP |
Spironolactone results in decreased expression of CXCL1 mRNA |
CTD |
PMID:21135038 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cybb |
cytochrome b-245 beta chain |
decreases expression |
EXP |
Spironolactone results in decreased expression of CYBB protein |
CTD |
PMID:19114643 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases expression |
EXP |
Spironolactone results in increased expression of CYP11B2 mRNA |
CTD |
PMID:15218317 |
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NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
Spironolactone results in decreased activity of CYP2C8 protein |
CTD |
PMID:15601807 |
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
Spironolactone results in increased expression of CYP3A4 mRNA |
CTD |
PMID:12505310 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions increases expression |
EXP |
NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA] |
CTD |
PMID:11752103 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases activity |
EXP |
Spironolactone results in decreased activity of CYP7A1 protein |
CTD |
PMID:15652244 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
increases expression |
EXP |
Spironolactone results in increased expression of ETS1 protein |
CTD |
PMID:20228418 |
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NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] |
CTD |
PMID:29782964 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein] |
CTD |
PMID:31295448 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gas6 |
growth arrest specific 6 |
multiple interactions affects expression |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein] Spironolactone affects the expression of GAS6 protein |
CTD |
PMID:19564549 |
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NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] |
CTD |
PMID:24512358 PMID:25204689 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased activity of GGT1 protein] |
CTD |
PMID:37328115 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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|
G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of GREB1 mRNA] |
CTD |
PMID:33405908 |
|
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein] |
CTD |
PMID:31295448 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
Spironolactone results in increased expression of GSTM1 mRNA |
CTD |
PMID:18723825 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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|
G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
ISO |
Spironolactone results in increased expression of GSTM2 mRNA; Spironolactone results in increased expression of GSTM5 mRNA |
CTD |
PMID:18723825 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO |
Spironolactone results in increased expression of GSTM3 mRNA |
CTD |
PMID:18723825 |
|
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
EXP |
Spironolactone results in increased expression of HIF1A protein |
CTD |
PMID:20228418 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
Spironolactone results in increased expression of HMOX1 mRNA; Spironolactone results in increased expression of HMOX1 protein |
CTD |
PMID:21263376 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hpse |
heparanase |
multiple interactions |
EXP |
[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] |
CTD |
PMID:19429930 |
|
NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
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|
G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]] |
CTD |
PMID:30993381 |
|
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases expression |
EXP |
Spironolactone results in decreased expression of HSD11B2 mRNA |
CTD |
PMID:17587755 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein] |
CTD |
PMID:17051331 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein] |
CTD |
PMID:17051331 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] |
CTD |
PMID:18660453 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
[Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein Spironolactone results in increased expression of IL1B protein |
CTD |
PMID:16528473 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein] |
CTD |
PMID:17051331 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein] Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]] Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein] |
CTD |
PMID:17051331 PMID:30993381 PMID:33359182 PMID:37328115 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein] |
CTD |
PMID:33359182 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] |
CTD |
PMID:29782964 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:15932931 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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|
G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased activity of LDHA protein] |
CTD |
PMID:37328115 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein] |
CTD |
PMID:31295448 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression |
EXP |
Spironolactone results in increased expression of MAP1LC3B protein |
CTD |
PMID:30734886 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
Spironolactone results in increased expression of MGST1 mRNA |
CTD |
PMID:18723825 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:24101390 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] |
CTD |
PMID:17616752 PMID:19333130 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] |
CTD |
PMID:19333130 |
|
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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|
G |
Mybl1 |
MYB proto-oncogene like 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of MYBL1 mRNA] |
CTD |
PMID:33405908 |
|
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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G |
Ncf2 |
neutrophil cytosolic factor 2 |
decreases expression |
EXP |
Spironolactone results in decreased expression of NCF2 protein |
CTD |
PMID:19114643 |
|
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] |
CTD |
PMID:25204689 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of NLRP3 protein] |
CTD |
PMID:37328115 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
ISO |
Spironolactone inhibits reaction [sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney] |
RGD |
PMID:24108235 |
RGD:38599161 |
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
increases expression |
EXP |
Spironolactone results in increased expression of NPHS2 protein |
CTD |
PMID:30734886 |
|
NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
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G |
Nppa |
natriuretic peptide A |
decreases expression multiple interactions |
ISO EXP |
Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:9595286 PMID:11300427 PMID:19966502 PMID:23288202 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
decreases expression multiple interactions |
ISO |
Spironolactone results in decreased expression of NPPB protein [carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein |
CTD |
PMID:11300427 PMID:21378469 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases expression |
ISO EXP |
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein Spironolactone results in increased expression of NR1I2 mRNA NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA] |
CTD |
PMID:11752103 PMID:15833929 PMID:15919853 PMID:16054614 PMID:17627975 PMID:21459122 PMID:33049310 More...
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|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
decreases expression multiple interactions increases activity |
EXP ISO |
Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein] Spironolactone results in increased activity of NR3C2 protein Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] |
CTD |
PMID:15780662 PMID:17587755 PMID:19114643 PMID:19966502 PMID:22798426 PMID:29149346 More...
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|
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein] |
CTD |
PMID:20508287 |
|
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of and results in increased secretion of PCSK9 protein] |
CTD |
PMID:37328115 |
|
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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G |
Plat |
plasminogen activator, tissue type |
increases expression |
ISO |
Spironolactone results in increased expression of PLAT protein |
CTD |
PMID:12424430 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium] |
CTD |
PMID:10100081 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Pon3 |
paraoxonase 3 |
increases hydrolysis |
ISO |
PON3 protein results in increased hydrolysis of Spironolactone |
CTD |
PMID:15772423 |
|
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression |
ISO |
Spironolactone results in increased expression of PPARA mRNA |
CTD |
PMID:17627975 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Prl |
prolactin |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein] |
CTD |
PMID:33359182 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Rac1 |
Rac family small GTPase 1 |
decreases expression |
EXP |
Spironolactone results in decreased expression of RAC1 protein |
CTD |
PMID:19114643 |
|
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Ren |
renin |
multiple interactions decreases response to substance increases expression |
ISO |
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein REN protein results in decreased susceptibility to Spironolactone Spironolactone results in increased expression of REN protein |
CTD |
PMID:6998872 PMID:9595286 PMID:12014310 PMID:20016520 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Serpine1 |
serpin family E member 1 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SERPINE1 protein |
CTD |
PMID:12424430 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions increases expression |
EXP ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA] Spironolactone results in increased expression of SGK1 mRNA Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA] |
CTD |
PMID:19429930 PMID:33405908 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Shbg |
sex hormone binding globulin |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in decreased secretion of SHBG protein] |
CTD |
PMID:37328115 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Slc12a2 |
solute carrier family 12 member 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] |
CTD |
PMID:12668585 |
|
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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|
G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
|
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
|
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:21641380 |
|
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc30a1 |
solute carrier family 30 member 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] |
CTD |
PMID:19333130 |
|
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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|
G |
Slc39a1 |
solute carrier family 39 member 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] |
CTD |
PMID:19333130 |
|
NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
ISO |
Spironolactone results in increased expression of SLCO1A4 mRNA |
CTD |
PMID:15919853 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SLCO1B2 mRNA |
CTD |
PMID:15919853 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Slco2a1 |
solute carrier organic anion transporter family, member 2a1 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SLCO2A1 mRNA |
CTD |
PMID:15919853 |
|
NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
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G |
Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SLCO2B1 mRNA |
CTD |
PMID:15919853 |
|
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] |
CTD |
PMID:17616752 PMID:19333130 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
Spironolactone results in increased expression of TFF1 mRNA |
CTD |
PMID:35307500 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions |
EXP |
Spironolactone results in decreased expression of TGFB1 protein Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein] |
CTD |
PMID:15130897 PMID:16928621 PMID:25204689 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnc |
tenascin C |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA] |
CTD |
PMID:21135038 |
|
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein] |
CTD |
PMID:16528473 PMID:17051331 PMID:33359182 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression increases activity |
EXP ISO |
Spironolactone results in increased expression of UGT1A1 mRNA Spironolactone results in increased activity of UGT1A1 protein |
CTD |
PMID:12818378 PMID:19144771 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A2 mRNA |
CTD |
PMID:19144771 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a3 |
UDP glycosyltransferase 1 family, polypeptide A3 |
increases expression increases activity |
EXP |
Spironolactone results in increased expression of UGT1A5 mRNA Spironolactone results in increased activity of UGT1A5 protein |
CTD |
PMID:12818378 |
|
NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A5 mRNA |
CTD |
PMID:19144771 |
|
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A6 mRNA |
CTD |
PMID:19144771 |
|
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a7c |
UDP glucuronosyltransferase 1 family, polypeptide A7C |
increases expression increases activity multiple interactions |
EXP |
Spironolactone results in increased expression of UGT1A7 protein Spironolactone results in increased activity of UGT1A7 protein [Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein |
CTD |
PMID:17686906 |
|
NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A9 mRNA |
CTD |
PMID:19144771 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
EXP |
Spironolactone results in increased expression of VEGFA protein |
CTD |
PMID:21263376 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Wt1 |
WT1 transcription factor |
increases expression |
EXP |
Spironolactone results in increased expression of WT1 protein |
CTD |
PMID:30734886 |
|
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport |
ISO |
ABCB1 protein results in increased transport of Strophanthidin |
CTD |
PMID:26708294 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
increases expression multiple interactions |
ISO |
Strophanthidin results in increased expression of G6PC1 mRNA Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter] |
CTD |
PMID:29981919 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Strophanthidin results in increased expression of and results in increased secretion of IL17A protein |
CTD |
PMID:29981919 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17f |
interleukin 17F |
multiple interactions |
ISO |
Strophanthidin results in increased expression of and results in increased secretion of IL17F protein |
CTD |
PMID:29981919 |
|
NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
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G |
Npas2 |
neuronal PAS domain protein 2 |
increases expression multiple interactions |
ISO |
Strophanthidin results in increased expression of NPAS2 mRNA Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
|
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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G |
Rorc |
RAR-related orphan receptor C |
multiple interactions increases expression |
ISO |
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
|
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] |
CTD |
PMID:20438634 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA] |
CTD |
PMID:34995708 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] |
CTD |
PMID:24632454 |
|
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein] |
CTD |
PMID:35734936 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alox15 |
arachidonate 15-lipoxygenase |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein] |
CTD |
PMID:35734936 |
|
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] |
CTD |
PMID:21266191 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
ISO |
withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein |
CTD |
PMID:20438634 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein] |
CTD |
PMID:35734936 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
withaferin A results in decreased expression of BCL2 protein withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein] |
CTD |
PMID:20438634 PMID:21256832 PMID:21964475 PMID:35734936 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l11 |
Bcl2-like 11 |
decreases expression multiple interactions |
ISO EXP |
withaferin A results in decreased expression of BCL2L11 protein withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein] |
CTD |
PMID:20438634 PMID:35734936 |
|
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein] withaferin A inhibits the reaction [Elements, Radioactive results in increased activity of CASP3 protein] |
CTD |
PMID:35734936 PMID:36716864 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein] |
CTD |
PMID:35734936 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases expression |
EXP ISO |
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein] withaferin A results in increased expression of CAT protein |
CTD |
PMID:35734936 PMID:36716864 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
affects binding multiple interactions increases expression |
ISO |
withaferin A binds to CDKN1A protein withaferin A results in increased expression of and affects the localization of CDKN1A protein withaferin A results in increased expression of CDKN1A mRNA |
CTD |
PMID:22973447 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn2aip |
CDKN2A interacting protein |
decreases expression |
ISO |
withaferin A results in decreased expression of CDKN2AIP protein |
CTD |
PMID:22973447 |
|
NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033
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G |
Cldn1 |
claudin 1 |
decreases response to substance decreases expression |
ISO |
CLDN1 protein results in decreased susceptibility to withaferin A withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein |
CTD |
PMID:33665778 |
|
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Cp |
ceruloplasmin |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein] |
CTD |
PMID:35734936 |
|
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpt1c |
carnitine palmitoyltransferase 1c |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA] |
CTD |
PMID:34995708 |
|
NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
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G |
Crp |
C-reactive protein |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein] |
CTD |
PMID:35734936 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
affects response to substance multiple interactions increases expression |
ISO |
DDIT3 mRNA affects the susceptibility to withaferin A Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein] |
CTD |
PMID:21266191 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] |
CTD |
PMID:21266191 |
|
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression |
ISO |
withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein |
CTD |
PMID:23593078 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
ISO |
withaferin A results in decreased expression of DNMT3A mRNA |
CTD |
PMID:23593078 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
ISO |
withaferin A results in decreased expression of DNMT3B mRNA |
CTD |
PMID:23593078 |
|
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Edil3 |
EGF like repeats and discoidin domains 3 |
decreases expression |
ISO |
withaferin A results in decreased expression of EDIL3 mRNA |
CTD |
PMID:33665778 |
|
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
multiple interactions |
ISO |
withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA] |
CTD |
PMID:34995708 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases phosphorylation |
ISO |
withaferin A results in increased phosphorylation of EIF2A protein |
CTD |
PMID:21266191 |
|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Ezr |
ezrin |
multiple interactions |
ISO |
[withanone co-treated with withaferin A] results in decreased expression of EZR protein |
CTD |
PMID:25236891 |
|
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein] |
CTD |
PMID:35734936 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA] |
CTD |
PMID:34995708 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
withaferin A results in increased expression of FOSL1 mRNA |
CTD |
PMID:33665778 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
withaferin A results in decreased expression of G6PC1 protein |
CTD |
PMID:37467946 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] |
CTD |
PMID:34995708 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein] |
CTD |
PMID:34995708 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
withaferin A binds to and affects the localization of GSR protein |
CTD |
PMID:37467946 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Hdac1 |
histone deacetylase 1 |
decreases expression |
ISO |
withaferin A results in decreased expression of HDAC1 protein |
CTD |
PMID:23593078 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
withaferin A results in increased expression of HMOX1 protein |
CTD |
PMID:36716864 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
multiple interactions |
ISO |
[withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein |
CTD |
PMID:25236891 |
|
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
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|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
withaferin A results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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|
G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
affects binding multiple interactions |
ISO |
withaferin A binds to HSPA9 protein [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein] |
CTD |
PMID:22973447 PMID:25236891 |
|
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:24632454 PMID:37467946 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein] |
CTD |
PMID:20438634 PMID:35734936 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Krt13 |
keratin 13 |
decreases expression |
ISO |
withaferin A results in decreased expression of KRT13 mRNA |
CTD |
PMID:33665778 |
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NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
ISO |
withaferin A results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:21964475 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases expression |
ISO |
MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] withaferin A results in increased expression of MCL1 protein |
CTD |
PMID:24019090 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mecp2 |
methyl CpG binding protein 2 |
decreases expression |
ISO |
withaferin A results in decreased expression of MECP2 protein |
CTD |
PMID:23593078 |
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NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
[withanone co-treated with withaferin A] results in decreased expression of MMP2 protein |
CTD |
PMID:25236891 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein] |
CTD |
PMID:35734936 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects binding increases phosphorylation |
ISO |
withaferin A binds to NFE2L2 protein withaferin A results in increased phosphorylation of NFE2L2 protein |
CTD |
PMID:22973447 PMID:36716864 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] |
CTD |
PMID:20438634 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein] |
CTD |
PMID:35734936 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA] |
CTD |
PMID:34995708 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nt5e |
5' nucleotidase, ecto |
increases expression |
ISO |
withaferin A results in increased expression of NT5E mRNA |
CTD |
PMID:33665778 |
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NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] |
CTD |
PMID:20438634 PMID:24019090 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Prdx2 |
peroxiredoxin 2 |
increases expression |
ISO |
withaferin A results in increased expression of PRDX2 protein |
CTD |
PMID:36716864 |
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NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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G |
Procr |
protein C receptor |
multiple interactions |
ISO |
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] |
CTD |
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