Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sphingolipid
go back to main search page
Accession:CHEBI:26739 term browser browse the term
Definition:Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.
Synonyms:related_synonym: sphingolipids


show annotations for term's descendants           Sort by:
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Il12b interleukin 12B increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases chemical synthesis		 ISO Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide] CTD PMID:14662772 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]] CTD PMID:16819191 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide] CTD PMID:16819191 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
alpha-galactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of GATA3 mRNA CTD PMID:30803854 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein CTD PMID:30993380 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion		 ISO [Alcohols co-treated with alpha-galactosylceramide] results in increased expression of IFNG protein; [Ovalbumin co-treated with alpha-galactosylceramide] results in increased secretion of IFNG protein
alpha-galactosylceramide results in increased secretion of IFNG protein		 CTD PMID:12482940 PMID:25499027 PMID:30803854 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL10 protein CTD PMID:30803854 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL13 protein CTD PMID:30803854 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL17A protein CTD PMID:30803854 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions		 ISO alpha-galactosylceramide results in increased secretion of IL4 protein
[Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL4 protein		 CTD PMID:12482940 PMID:30803854 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased secretion of IL5 protein CTD PMID:30803854 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Klrb1b killer cell lectin like receptor B1B decreases expression ISO alpha-galactosylceramide results in decreased expression of KLRB1C protein CTD PMID:30993380 NCBI chr 4:161,948,259...161,961,537
Ensembl chr 4:161,890,577...161,961,675 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in decreased expression of RORC mRNA alternative form CTD PMID:30803854 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO [Ovalbumin co-treated with alpha-galactosylceramide] results in increased expression of TBX21 mRNA CTD PMID:30803854 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos2 nitric oxide synthase 2 multiple interactions ISO ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites] CTD PMID:31202640 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
ceramide 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cerk ceramide kinase affects abundance ISO CERK protein affects the abundance of ceramide 1-phosphate CTD PMID:15899891 NCBI chr 7:117,225,855...117,269,436
Ensembl chr 7:117,225,855...117,268,759 		JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule multiple interactions EXP CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide] CTD PMID:16651628 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP G(M1) Ganglioside results in increased expression of CDKN1A protein CTD PMID:15654767 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression EXP G(M1) Ganglioside results in decreased expression of CDKN1B protein CTD PMID:15654767 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects localization ISO NPC1 affects the localization of G(M1) Ganglioside CTD PMID:12183525 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions EXP G(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]; G(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein] CTD PMID:25545984 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Pld1 phospholipase D1 multiple interactions EXP PLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP PLD2 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression EXP G(M1) Ganglioside results in increased expression of SLC18A2 mRNA CTD PMID:14552908 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression EXP G(M1) Ganglioside results in increased expression of SLC6A3 mRNA CTD PMID:14552908 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Th tyrosine hydroxylase increases activity EXP G(M1) Ganglioside results in increased activity of TH protein CTD PMID:14552908 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP G(M1) Ganglioside results in decreased expression of TLR4 protein CTD PMID:16651628 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
myriocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO thermozymocidin inhibits the reaction [Dexamethasone results in increased expression of ACACA mRNA] CTD PMID:31053639 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO thermozymocidin results in increased expression of ANGPTL4 mRNA CTD PMID:31053639 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO thermozymocidin inhibits the reaction [Dronabinol results in increased activity of CASP3 protein]; thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein] CTD PMID:15596715 PMID:16818650 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of DDIT3 protein]; thermozymocidin inhibits the reaction [Resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 PMID:31891755 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO thermozymocidin inhibits the reaction [[sorafenib co-treated with vorinostat] affects the localization of and results in increased activity of FAS protein] CTD PMID:18787411 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [thermozymocidin results in increased susceptibility to Dexamethasone] which results in decreased expression of FASN mRNA CTD PMID:31053639 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein] CTD PMID:31891755 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO thermozymocidin inhibits the reaction [Dronabinol results in increased expression of and affects the localization of and affects the lipidation of MAP1LC3B protein] CTD PMID:27635674 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO
EXP		 thermozymocidin inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA] CTD PMID:16616335 PMID:16818650 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in decreased activity of ODC1 protein] CTD PMID:17521618 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO thermozymocidin inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prkcz protein kinase C, zeta decreases activity ISO thermozymocidin results in decreased activity of PRKCZ protein CTD PMID:31053639 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
N,N-dimethylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein CTD PMID:21195056 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C5 complement C5 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21195056 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:21998146 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein CTD PMID:21195056 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein CTD PMID:21195056 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sphk1 sphingosine kinase 1 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 N,N-dimethylsphingosine results in decreased activity of SPHK1 protein
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]
N,N-dimethylsphingosine results in decreased expression of SPHK1 protein		 CTD PMID:17065523 PMID:19284563 PMID:21195056 PMID:21998146 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
N-acetylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO N-acetylsphingosine results in increased expression of ABCB1 CTD PMID:11573427 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein
N-acetylsphingosine results in decreased phosphorylation of AKT1 protein		 CTD PMID:12640124 PMID:16215670 PMID:21821001 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions		 ISO N-acetylsphingosine results in decreased phosphorylation of BAD protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein]		 CTD PMID:24420784 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of BAX mRNA
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein]		 CTD PMID:24420784 PMID:33959992 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]
N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein		 CTD PMID:9295281 PMID:16215670 PMID:24420784 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases degradation		 ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] CTD PMID:21821001 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO [C2-ceramide cotreated with paclitaxel] decreases expression of BIRC2 mRNA in non-small cell lung cancer cells RGD PMID:20624405 RGD:152999014 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO [C2-ceramide cotreated with paclitaxel] decreases expression of BIRC3 mRNA in non-small cell lung cancer cells RGD PMID:20624405 RGD:152999014 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein
N-acetylsphingosine results in increased activity of CASP3 protein		 CTD PMID:10919278 PMID:16215670 PMID:21259059 PMID:28052715 PMID:33959992 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:12640124 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases localization		 EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] CTD PMID:15319326 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO N-acetylsphingosine results in increased activity of CFTR protein CTD PMID:15474513 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO N-acetylsphingosine results in decreased expression of CLDN4 mRNA; N-acetylsphingosine results in decreased expression of CLDN4 protein CTD PMID:28052715 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO N-acetylsphingosine results in increased expression of CLK1 mRNA CTD PMID:18270325 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Ctsd cathepsin D increases secretion EXP N-acetylsphingosine results in increased secretion of CTSD protein CTD PMID:15040013 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Dapk1 death associated protein kinase 1 increases activity ISO
EXP		 N-acetylsphingosine results in increased activity of DAPK1 protein CTD PMID:17087515 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dffb DNA fragmentation factor subunit beta increases activity EXP N-acetylsphingosine results in increased activity of DFFB protein CTD PMID:15040013 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dnm1l dynamin 1-like increases expression EXP N-acetylsphingosine results in increased expression of DNM1L protein CTD PMID:18006463 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression		 ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]
N-acetylsphingosine results in increased expression of F3 protein		 CTD PMID:27556861 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP N-acetylsphingosine results in increased expression of FIS1 protein CTD PMID:18006463 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GOT1 protein] CTD PMID:33959992 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:33959992 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of GPX3 protein] CTD PMID:33959992 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation ISO N-acetylsphingosine results in decreased phosphorylation of GSK3A protein CTD PMID:21821001 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions		 ISO N-acetylsphingosine results in decreased phosphorylation of GSK3B protein
N-acetylsphingosine results in decreased expression of GSK3B protein modified form
GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]		 CTD PMID:21821001 PMID:24420784 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of and results in increased secretion of GSTA1 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of GSTA1 mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of GSTA1 protein] CTD PMID:31385618 PMID:33959992 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
decreases expression		 EXP N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]
N-acetylsphingosine results in decreased expression of GSTA2 protein		 CTD PMID:15155840 PMID:15319326 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA3 protein CTD PMID:15155840 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA5 protein CTD PMID:15155840 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO N-acetylsphingosine results in decreased expression of HMOX1 mRNA CTD PMID:18270325 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions
decreases ubiquitination		 EXP
ISO		 N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A protein]
N-acetylsphingosine results in decreased ubiquitination of HNF1A protein		 CTD PMID:15155840 PMID:31385618 PMID:33959992 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of HRK mRNA
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]		 CTD PMID:24420784 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO N-acetylsphingosine results in decreased expression of ID2 mRNA CTD PMID:18270325 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Il16 interleukin 16 increases expression ISO N-acetylsphingosine results in increased expression of IL16 mRNA CTD PMID:18270325 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] CTD PMID:27556861 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of JUN protein] CTD PMID:33959992 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]		 CTD PMID:15313899 PMID:15741222 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Klf6 KLF transcription factor 6 increases expression ISO N-acetylsphingosine results in increased expression of KLF6 mRNA CTD PMID:18270325 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Lgals3 galectin 3 multiple interactions
increases expression
decreases response to substance		 ISO 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to N-acetylsphingosine		 CTD PMID:21821001 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] CTD PMID:18270325 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity EXP N-acetylsphingosine results in increased activity of MAPK1 protein CTD PMID:10700234 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity EXP N-acetylsphingosine results in increased activity of MAPK3 protein CTD PMID:10700234 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] CTD PMID:33959992 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:18270325 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases degradation		 ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] CTD PMID:21821001 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mfn2 mitofusin 2 decreases response to substance EXP MFN2 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:18006463 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir15b microRNA 15b decreases expression ISO N-acetylsphingosine results in decreased expression of MIR15B mRNA CTD PMID:20145152 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir20a microRNA 20a decreases expression ISO N-acetylsphingosine results in decreased expression of MIR20A mRNA CTD PMID:20145152 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir25 microRNA 25 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR25 mRNA CTD PMID:20145152 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015 		JBrowse link
G Mir93 microRNA 93 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR93 mRNA CTD PMID:20145152 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7B mRNA CTD PMID:20145152 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7D mRNA CTD PMID:20145152 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7I mRNA CTD PMID:20145152 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases localization		 EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] CTD PMID:15319326 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] CTD PMID:12381813 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Ocln occludin decreases expression ISO N-acetylsphingosine results in decreased expression of OCLN mRNA; N-acetylsphingosine results in decreased expression of OCLN protein CTD PMID:28052715 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO N-acetylsphingosine results in decreased activity of ODC1 protein CTD PMID:17521618 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO N-acetylsphingosine results in increased activity of PARP1 protein CTD PMID:24420784 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases response to substance ISO PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases activity EXP N-acetylsphingosine results in increased activity of RAF1 protein CTD PMID:10700234 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects activity ISO N-acetylsphingosine affects the activity of RELA protein CTD PMID:12853972 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhob ras homolog family member B increases expression ISO N-acetylsphingosine results in increased expression of RHOB mRNA CTD PMID:18270325 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein CTD PMID:11107162 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:33959992 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO
EXP		 N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]		 CTD PMID:9535218 PMID:10428046 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein CTD PMID:29945972 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO N-acetylsphingosine results in increased expression of TGIF1 mRNA CTD PMID:18270325 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO N-acetylsphingosine results in decreased expression of TJP1 mRNA; N-acetylsphingosine results in decreased expression of TJP1 protein CTD PMID:28052715 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]
N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein		 CTD PMID:9535218 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 decreases activity
multiple interactions		 ISO N-acetylsphingosine results in decreased activity of TXN protein
TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]		 CTD PMID:18270325 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of TXNIP protein
N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein
TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]		 CTD PMID:18270325 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
N-acylsphinganine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression ISO dihydroceramide analog results in increased expression of ATF4 protein CTD PMID:32397857 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP3 protein CTD PMID:17586710 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP6 protein CTD PMID:17586710 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP9 protein CTD PMID:17586710 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 multiple interactions ISO [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in decreased activity of DEGS1 protein] which results in decreased reduction of dihydroceramide CTD PMID:27635674 NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO dihydroceramide analog results in increased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:32397857 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO dihydroceramide analog results in increased expression of TRIB3 protein CTD PMID:32397857 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
N-hexadecanoylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:15946935 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of ATF4 mRNA
ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]		 CTD PMID:28223344 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of ATF6 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]		 CTD PMID:28223344 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Cs citrate synthase decreases expression
multiple interactions		 ISO N-palmitoylsphingosine results in decreased expression of CS mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA]		 CTD PMID:28223344 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] CTD PMID:28223344 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] CTD PMID:28223344 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance		 ISO (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:27556861 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases expression		 ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of ITPR2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]		 CTD PMID:28223344 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of MFN2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]		 CTD PMID:28223344 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression
multiple interactions		 ISO N-palmitoylsphingosine results in increased expression of PACS2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA]		 CTD PMID:28223344 NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583 		JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Tnf tumor necrosis factor increases abundance
multiple interactions		 ISO TNF protein results in increased abundance of N-palmitoylsphingosine
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]		 CTD PMID:15946935 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
phytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions		 ISO phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]		 CTD PMID:15486061 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects localization		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine results in increased expression of BAX protein
phytosphingosine affects the localization of BAX protein		 CTD PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO phytosphingosine results in increased expression of BCL2 protein CTD PMID:36334778 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]
phytosphingosine results in increased expression of CASP3 protein		 CTD PMID:17237268 PMID:36334778 PMID:37956922 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]
phytosphingosine results in increased expression of CASP9 protein		 CTD PMID:17237268 PMID:37956922 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO phytosphingosine results in decreased expression of CCNB1 protein CTD PMID:37956922 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO phytosphingosine results in decreased expression of CDK1 protein CTD PMID:37956922 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO phytosphingosine results in increased expression of CYCS protein CTD PMID:36334778 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein CTD PMID:17237268 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] CTD PMID:17237268 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein CTD PMID:17237268 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases activity		 ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased cleavage of PARP1 protein
phytosphingosine results in increased activity of PARP1 protein		 CTD PMID:15486061 PMID:17237268 PMID:37956922 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases expression ISO phytosphingosine results in decreased expression of PINK1 protein CTD PMID:36334778 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
rosuvastatin calcium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions		 ISO Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]		 CTD PMID:18192897 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium		 CTD PMID:15901796 PMID:19853032 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
affects secretion		 ISO
EXP		 ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium		 CTD PMID:19853032 PMID:23562342 PMID:24909372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Rosuvastatin Calcium results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA CTD PMID:18192897 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity		 EXP
ISO		 [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein		 CTD PMID:19853032 PMID:30083819 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein] CTD PMID:28441890 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Rosuvastatin Calcium affects the phosphorylation of AKT1 protein CTD PMID:27815113 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression		 ISO Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] CTD PMID:12767421 PMID:15539964 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B decreases expression ISO Rosuvastatin Calcium results in decreased expression of APOB protein CTD PMID:15539964 PMID:18702965 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:32007421 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Rosuvastatin Calcium results in decreased expression of BCL2 protein CTD PMID:20852871 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C3 complement C3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of C3 mRNA CTD PMID:32771489 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein		 CTD PMID:21478229 PMID:32771489 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]		 CTD PMID:20146376 PMID:32007421 PMID:35130744 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rosuvastatin Calcium results in decreased expression of CCL2 mRNA CTD PMID:15681303 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Rosuvastatin Calcium results in decreased expression of CREB5 mRNA CTD PMID:18192897 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325 		JBrowse link
G Crp C-reactive protein multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] CTD PMID:21562509 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression		 EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species		 CTD PMID:16633368 PMID:21562509 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ESR1 protein CTD PMID:32771489 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA		 CTD PMID:18154958 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] CTD PMID:18192897 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G Gzmk granzyme K multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] CTD PMID:18192897 NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Rosuvastatin Calcium CTD PMID:27160211 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression
multiple interactions		 ISO Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]		 CTD PMID:18192897 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Rosuvastatin Calcium results in decreased expression of IL1B mRNA CTD PMID:15681303 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 decreases expression ISO Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA CTD PMID:18192897 NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mb myoglobin affects expression EXP Rosuvastatin Calcium affects the expression of MB protein CTD PMID:27815113 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Mstn myostatin increases expression ISO Rosuvastatin Calcium results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] CTD PMID:32007421 PMID:35130744 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]		 CTD PMID:21443142 PMID:32007421 PMID:35130744 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects response to substance		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium		 CTD PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] CTD PMID:18192897 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Selp selectin P decreases expression EXP Rosuvastatin Calcium results in decreased expression of SELP mRNA CTD PMID:15681303 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases expression
affects transport		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium		 CTD PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:26888941 PMID:31299240 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases uptake
multiple interactions		 ISO SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:24285294 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of TFF1 mRNA CTD PMID:32771489 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA		 CTD PMID:15681303 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 EXP Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]		 CTD PMID:15681303 PMID:32007421 PMID:35130744 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32007421 PMID:35130744 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Vnn3 vanin 3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of VNN3P mRNA CTD PMID:18192897 NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626 		JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Rosuvastatin Calcium results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
sphinganine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]
dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA; dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein		 CTD PMID:18612546 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate decreases abundance ISO SPNS2 protein results in decreased abundance of dihydrosphingosine 1-phosphate CTD PMID:29772789 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 multiple interactions EXP Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Sphingosine results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] CTD PMID:9398635 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tert telomerase reverse transcriptase affects activity ISO Sphingosine affects the activity of TERT protein CTD PMID:9434777 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 protein]
sphingosine 1-phosphate results in increased expression of ACTA2 mRNA; sphingosine 1-phosphate results in increased expression of ACTA2 protein		 CTD PMID:37169277 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein		 CTD PMID:15946935 PMID:16365044 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of ATG5 mRNA; sphingosine 1-phosphate results in increased expression of ATG5 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 protein]		 CTD PMID:37169277 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 ISO sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24399507 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507 PMID:24420784 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of BECN1 mRNA; sphingosine 1-phosphate results in increased expression of BECN1 protein
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 protein]		 CTD PMID:37169277 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of and results in increased cleavage of CASP1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of CASP1 mRNA] CTD PMID:37169277 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of COL1A1 mRNA; sphingosine 1-phosphate results in increased expression of COL1A1 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of COL1A1 mRNA]		 CTD PMID:37169277 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]		 CTD PMID:18612546 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]		 CTD PMID:26518876 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of FN1 protein] CTD PMID:21998146 PMID:22406263 PMID:37169277 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] CTD PMID:25769802 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]] CTD PMID:25769802 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507 PMID:24420784 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO sphingosine 1-phosphate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of IL18 protein] CTD PMID:37169277 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion		 ISO sphingosine 1-phosphate results in increased expression of IL1B mRNA
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein CTD PMID:32401414 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of MAP1LC3B mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein
sphingosine 1-phosphate results in increased expression of MAP1LC3B mRNA		 CTD PMID:37169277 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein		 CTD PMID:26518876 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein		 CTD PMID:25980589 PMID:26518876 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 protein] CTD PMID:37169277 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression
multiple interactions		 ISO sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]		 CTD PMID:25980589 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein		 CTD PMID:18612546 PMID:26518876 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases response to substance
affects binding
multiple interactions
increases expression		 EXP
ISO		 S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
S1PR1 protein binds to sphingosine 1-phosphate
S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein		 CTD PMID:20844107 PMID:24399507 PMID:32401414 PMID:35412894 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions
increases expression
increases uptake
increases activity		 ISO
EXP		 S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased expression of S1PR2 protein
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR2 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of S1PR2 protein]		 CTD PMID:18612546 PMID:22406263 PMID:26518876 PMID:37169277 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546 PMID:25980589 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 multiple interactions ISO Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein CTD PMID:30102254 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795 		JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation EXP sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein CTD PMID:37169277 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Sphk1 sphingosine kinase 1 increases chemical synthesis
multiple interactions		 ISO SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]		 CTD PMID:22251058 PMID:24399507 PMID:26045781 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate increases secretion
multiple interactions		 ISO SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]		 CTD PMID:29772789 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP sphingosine 1-phosphate results in decreased expression of SQSTM1 protein CTD PMID:37169277 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 PMID:26518876 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          nitrogen atom 19025
            nitrogen molecular entity 19025
              organonitrogen compound 18846
                sphingolipid 218
                  (+)-Prosopinine 0
                  1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-D-xylo-phytosphingosine 0
                  L-erythro-N-acylsphingosine + 0
                  L-erythro-N-dodecanoylsphingosine 0
                  N-acyl-3-ketodihydrosphingosine + 0
                  Sphingosine 1-phosphate (d19:1-P) 0
                  ceramide + 128
                  glycosphingolipid + 41
                  hexadecasphinganine-based sphingolipid 0
                  hexadecasphingosine-based sphingolipid 0
                  phosphonosphingolipid + 0
                  phosphosphingolipid + 98
                  sphinganine-based sphingolipid + 7
                  sphingoid + 196
                  sphingosine-based sphingolipid + 93
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  sphingolipid 218
                                    (+)-Prosopinine 0
                                    1-O-(alpha-D-galactopyranosyl)-N-hexacosanoyl-D-xylo-phytosphingosine 0
                                    L-erythro-N-acylsphingosine + 0
                                    L-erythro-N-dodecanoylsphingosine 0
                                    N-acyl-3-ketodihydrosphingosine + 0
                                    Sphingosine 1-phosphate (d19:1-P) 0
                                    ceramide + 128
                                    glycosphingolipid + 41
                                    hexadecasphinganine-based sphingolipid 0
                                    hexadecasphingosine-based sphingolipid 0
                                    phosphonosphingolipid + 0
                                    phosphosphingolipid + 98
                                    sphinganine-based sphingolipid + 7
                                    sphingoid + 196
                                    sphingosine-based sphingolipid + 93
paths to the root