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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ammothamnine
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Accession:CHEBI:2672 term browser browse the term
Definition:An alkaloid that has formula C15H24N2O2.
Synonyms:related_synonym: Formula=C15H24N2O2;   InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1;   InChIKey=XVPBINOPNYFXID-LHDUFFHYSA-N;   Matrine N-oxide;   Oxymatrine;   SMILES=C1[C@]2(CN3[C@@]([C@]4(CCC[N+](CC1)([C@@]24[H])[O-])[H])(CCCC3=O)[H])[H]
 xref: CAS:16837-52-8;   KEGG:C10749;   KNApSAcK:C00007758
 xref_mesh: MESH:C037573


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Ammothamnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan multiple interactions ISO oxymatrine inhibits the reaction [IL1B protein results in decreased expression of ACAN protein] CTD PMID:37196756 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO oxymatrine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]
oxymatrine inhibits the reaction [SNHG6 results in increased expression of ACTA2 protein]		 CTD PMID:33241020 PMID:35785413 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 multiple interactions ISO oxymatrine inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein] CTD PMID:37196756 NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions ISO oxymatrine inhibits the reaction [sodium arsenite results in decreased expression of ATP2A1 mRNA] CTD PMID:33241020 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [oxymatrine co-treated with sodium arsenite] results in decreased expression of ATP2A2 protein CTD PMID:33241020 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO oxymatrine analog inhibits the reaction [TNF protein results in decreased expression of BAX protein]
oxymatrine results in increased expression of BAX protein		 CTD PMID:34459104 PMID:39419199 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of BCL2 protein]
oxymatrine results in decreased expression of BCL2 protein		 CTD PMID:34459104 PMID:39419199 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions		 ISO oxymatrine results in increased expression of CAPN2 protein
oxymatrine promotes the reaction [sodium arsenite results in increased expression of CAPN2 protein]		 CTD PMID:33241020 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO oxymatrine results in increased cleavage of CASP3 protein CTD PMID:39419199 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO oxymatrine results in increased cleavage of CASP9 protein CTD PMID:39419199 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP oxymatrine inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein] CTD PMID:27713174 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of CCN2 protein] CTD PMID:35785413 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO oxymatrine results in increased expression of CDH1 protein CTD PMID:39419199 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cldn2 claudin 2 multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein] CTD PMID:35290143 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of COL1A1 protein] CTD PMID:35785413 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of CREBBP mRNA] CTD PMID:18395914 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO oxymatrine results in decreased expression of CTNNB1 protein CTD PMID:39419199 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:23568217 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
decreases expression		 ISO oxymatrine results in increased expression of DDIT3 mRNA
oxymatrine inhibits the reaction [sodium arsenite results in increased expression of DDIT3 protein]; oxymatrine promotes the reaction [sodium arsenite results in increased expression of DDIT3 mRNA]
oxymatrine results in decreased expression of DDIT3 protein		 CTD PMID:33241020 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of FN1 protein] CTD PMID:35785413 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:15603720 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO		 oxymatrine promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
NFE2L2 protein promotes the reaction [oxymatrine promotes the reaction [IL1B protein results in increased expression of HMOX1 protein]]; oxymatrine promotes the reaction [IL1B protein results in increased expression of HMOX1 protein]		 CTD PMID:27713174 PMID:37196756 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
multiple interactions		 ISO oxymatrine results in decreased expression of HSPA5 mRNA
oxymatrine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 mRNA]; oxymatrine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]		 CTD PMID:33241020 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IFNG protein] CTD PMID:15603720 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein] CTD PMID:15603720 PMID:35290143 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 [oxymatrine co-treated with IL1B protein] results in decreased expression of NFE2L2 protein; NFE2L2 protein promotes the reaction [oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]]; NFE2L2 protein promotes the reaction [oxymatrine promotes the reaction [IL1B protein results in increased expression of HMOX1 protein]]; oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; oxymatrine inhibits the reaction [IL1B protein results in decreased expression of ACAN protein]; oxymatrine inhibits the reaction [IL1B protein results in decreased expression of NFKBIA protein]; oxymatrine inhibits the reaction [IL1B protein results in increased abundance of Nitrites]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of TNF protein]; oxymatrine inhibits the reaction [IL1B protein results in increased secretion of LDHA protein]; oxymatrine promotes the reaction [IL1B protein results in increased expression of HMOX1 protein]; oxymatrine promotes the reaction [IL1B protein results in increased expression of NFE2L2 protein]
oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL1B protein]
oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]		 CTD PMID:23568217 PMID:34459104 PMID:35290143 PMID:37196756 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2 protein] CTD PMID:15603720 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]		 CTD PMID:23568217 PMID:34459104 PMID:35290143 PMID:37196756 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
increases expression		 ISO oxymatrine inhibits the reaction [arsenic trioxide results in decreased localization of KCNH2 protein]
oxymatrine results in increased expression of KCNH2 protein		 CTD PMID:23103450 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased stability of and results in increased localization of NFE2L2 protein; oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein] CTD PMID:37196756 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO oxymatrine inhibits the reaction [IL1B protein results in increased secretion of LDHA protein] CTD PMID:37196756 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [oxymatrine results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [oxymatrine results in decreased phosphorylation of MAPK3 protein]; oxymatrine results in decreased phosphorylation of and results in increased stability of MAP2K1 protein CTD PMID:39419199 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO MAP2K1 protein inhibits the reaction [oxymatrine results in decreased phosphorylation of MAPK1 protein] CTD PMID:39419199 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO oxymatrine results in decreased phosphorylation of MAPK3 protein
MAP2K1 protein inhibits the reaction [oxymatrine results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:39419199 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP1 protein] CTD PMID:34459104 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
oxymatrine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]		 CTD PMID:34459104 PMID:37196756 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein] CTD PMID:35290143 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO		 oxymatrine promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]
[oxymatrine co-treated with IL1B protein] results in decreased expression of NFE2L2 protein; [oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased stability of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]]; NFE2L2 protein promotes the reaction [oxymatrine promotes the reaction [IL1B protein results in increased expression of HMOX1 protein]]; oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; oxymatrine promotes the reaction [IL1B protein results in increased expression of NFE2L2 protein]		 CTD PMID:27713174 PMID:37196756 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO oxymatrine inhibits the reaction [IL1B protein results in decreased expression of NFKBIA protein] CTD PMID:37196756 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
oxymatrine inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]		 CTD PMID:34459104 PMID:37196756 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ocln occludin multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein] CTD PMID:35290143 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Ptgis prostaglandin I2 synthase increases expression EXP Oxymatrine increases expression of Ptgis protein in the heart left ventricle RGD PMID:27802898 RGD:401960097 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
oxymatrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]		 CTD PMID:34459104 PMID:37196756 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 EXP
ISO		 oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
oxymatrine analog inhibits the reaction [TNF protein results in increased expression of RELA protein modified form]
NFE2L2 protein promotes the reaction [oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]
oxymatrine results in decreased expression of RELA protein		 CTD PMID:23568217 PMID:34459104 PMID:35290143 PMID:37196756 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions
increases expression		 ISO oxymatrine promotes the reaction [sodium arsenite results in increased expression of RYR1 mRNA]
oxymatrine results in increased expression of RYR1 mRNA		 CTD PMID:33241020 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Smad2 SMAD family member 2 decreases expression ISO oxymatrine results in decreased expression of SMAD2 protein CTD PMID:35785413 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression		 ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]
oxymatrine results in decreased expression of SMAD3 protein		 CTD PMID:18395914 PMID:35785413 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 increases expression ISO oxymatrine results in increased expression of SMAD7 mRNA CTD PMID:18395914 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
oxymatrine inhibits the reaction [sodium arsenite results in increased secretion of TGFB1 protein]		 CTD PMID:18395914 PMID:33241020 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633229 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein] CTD PMID:35290143 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein] CTD PMID:35290143 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 oxymatrine inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; oxymatrine inhibits the reaction [IL1B protein results in increased expression of TNF protein]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
oxymatrine analog inhibits the reaction [TNF protein results in decreased expression of BAX protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL1B protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP1 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of RELA protein modified form]		 CTD PMID:15603720 PMID:23568217 PMID:34459104 PMID:35290143 PMID:37196756 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of VIM protein]
oxymatrine results in decreased expression of VIM protein		 CTD PMID:35785413 PMID:39419199 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          metabolite 19561
            alkaloid 8026
              Ammothamnine 54
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            inorganic hydride 18183
                              pnictogen hydride 18173
                                nitrogen hydride 18086
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        tertiary amino compound 10159
                                          tertiary amine oxide 59
                                            Ammothamnine 54
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