CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | amiodarone |
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Accession: | CHEBI:2663
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browse the term
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Definition: | A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. |
Synonyms: | exact_synonym: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone |
| related_synonym: | 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran; Formula=C25H29I2NO3; InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3; InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N; SMILES=CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1; amiodarona; amiodaronum |
| xref: | Beilstein:1271711; CAS:1951-25-3; DrugBank:DB01118; Drug_Central:176; HMDB:HMDB0015250; KEGG:C06823; KEGG:D02910; LINCS:LSM-2379 |
| xref_mesh: | MESH:D000638 |
| xref: | PMID:10188629; PMID:16479044; PMID:18368867; Patent:CA2826272; Patent:TW201400111; Wikipedia:Amiodarone |
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AADAT |
aminoadipate aminotransferase |
affects expression |
ISO |
Amiodarone affects the expression of AADAT mRNA |
CTD |
PMID:18355885 |
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NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699
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ABCA1 |
ATP binding cassette subfamily A member 1 |
decreases expression |
EXP |
Amiodarone results in decreased expression of ABCA1 mRNA |
CTD |
PMID:29248575 |
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NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
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ABCA2 |
ATP binding cassette subfamily A member 2 |
increases expression |
EXP |
Amiodarone results in increased expression of ABCA2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915
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ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions affects expression affects response to substance decreases activity |
EXP ISO |
Amiodarone inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] Amiodarone affects the expression of ABCB1 mRNA; Amiodarone affects the expression of ABCB1A mRNA Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] ABCB1A protein affects the susceptibility to Amiodarone Amiodarone results in decreased activity of ABCB1 protein |
CTD |
PMID:11231118 PMID:12235267 PMID:15502009 PMID:18355885 PMID:19483382 |
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NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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ABCB11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases expression decreases activity |
EXP ISO |
Amiodarone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Amiodarone results in decreased expression of ABCB11 mRNA Amiodarone results in decreased activity of ABCB11 protein |
CTD |
PMID:20829430 PMID:24014644 PMID:27765674 |
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NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
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ABCB4 |
ATP binding cassette subfamily B member 4 |
increases expression decreases expression |
ISO |
Amiodarone results in increased expression of ABCB4 mRNA Amiodarone results in decreased expression of ABCB4 mRNA |
CTD |
PMID:24489787 PMID:27765674 |
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NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
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ABCC11 |
ATP binding cassette subfamily C member 11 |
increases expression |
EXP |
Amiodarone results in increased expression of ABCC11 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:48,164,819...48,247,539
Ensembl chr16:48,165,773...48,247,568
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ABCC2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
Amiodarone results in increased expression of ABCC2 mRNA |
CTD |
PMID:27765674 |
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NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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ABCC3 |
ATP binding cassette subfamily C member 3 |
increases expression decreases expression |
ISO |
Amiodarone results in increased expression of ABCC3 mRNA Amiodarone results in decreased expression of ABCC3 mRNA |
CTD |
PMID:24489787 PMID:27765674 |
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NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
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ABCC4 |
ATP binding cassette subfamily C member 4 (PEL blood group) |
decreases expression |
ISO |
Amiodarone results in decreased expression of ABCC4 mRNA |
CTD |
PMID:27765674 |
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NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
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ABCC6 |
ATP binding cassette subfamily C member 6 |
affects expression |
ISO |
Amiodarone affects the expression of ABCC6 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522
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ABCD3 |
ATP binding cassette subfamily D member 3 |
increases expression |
ISO |
Amiodarone results in increased expression of ABCD3 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 1:94,385,131...94,518,663
Ensembl chr 1:94,418,389...94,518,666
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ABCD4 |
ATP binding cassette subfamily D member 4 |
increases expression |
ISO |
Amiodarone results in increased expression of ABCD4 mRNA |
CTD |
PMID:24489787 |
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NCBI chr14:74,285,269...74,302,934
Ensembl chr14:74,285,269...74,303,055
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ABCG5 |
ATP binding cassette subfamily G member 5 |
affects expression increases expression |
ISO |
Amiodarone affects the expression of ABCG5 mRNA Amiodarone results in increased expression of ABCG5 mRNA |
CTD |
PMID:19483382 PMID:27765674 |
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NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865
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ABHD1 |
abhydrolase domain containing 1 |
affects expression |
ISO |
Amiodarone affects the expression of ABHD1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 2:27,123,815...27,130,812
Ensembl chr 2:27,123,789...27,130,812
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ABHD14B |
abhydrolase domain containing 14B |
affects expression |
ISO |
Amiodarone affects the expression of ABHD14B mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:51,968,510...51,974,630
Ensembl chr 3:51,968,510...51,983,409
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ABHD17A |
abhydrolase domain containing 17A, depalmitoylase |
affects expression |
ISO |
Amiodarone affects the expression of ABHD17A mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:1,876,810...1,885,496
Ensembl chr19:1,876,810...1,885,496
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ABL1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
increases expression |
EXP |
Amiodarone results in increased expression of ABL1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675
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ACAA1 |
acetyl-CoA acyltransferase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of ACAA1 mRNA |
CTD |
PMID:15265979 |
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NCBI chr 3:38,122,715...38,137,127
Ensembl chr 3:38,103,129...38,137,242
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ACACA |
acetyl-CoA carboxylase alpha |
affects expression increases expression |
ISO EXP |
Amiodarone affects the expression of ACACA mRNA Amiodarone results in increased expression of ACACA mRNA |
CTD |
PMID:19483382 PMID:19774075 |
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NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
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ACACB |
acetyl-CoA carboxylase beta |
increases expression |
ISO |
Amiodarone results in increased expression of ACACB mRNA |
CTD |
PMID:19224547 PMID:24489787 |
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NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226
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ACAD10 |
acyl-CoA dehydrogenase family member 10 |
increases expression |
ISO |
Amiodarone results in increased expression of ACAD10 mRNA |
CTD |
PMID:24535564 |
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NCBI chr12:111,686,053...111,757,099
Ensembl chr12:111,686,053...111,757,107
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ACAD9 |
acyl-CoA dehydrogenase family member 9 |
increases expression |
ISO |
Amiodarone results in increased expression of ACAD9 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 3:128,879,620...128,913,114
Ensembl chr 3:128,879,596...128,924,003
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ACADL |
acyl-CoA dehydrogenase long chain |
affects expression |
ISO |
Amiodarone affects the expression of ACADL mRNA |
CTD |
PMID:19483382 |
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NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
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ACADM |
acyl-CoA dehydrogenase medium chain |
increases expression |
ISO |
Amiodarone results in increased expression of ACADM mRNA |
CTD |
PMID:24489787 |
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NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575
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ACAT1 |
acetyl-CoA acetyltransferase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of ACAT1 mRNA |
CTD |
PMID:24489787 |
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NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,148,957
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ACAT2 |
acetyl-CoA acetyltransferase 2 |
increases expression |
ISO |
Amiodarone results in increased expression of ACAT2 mRNA |
CTD |
PMID:32084307 |
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NCBI chr 6:159,762,045...159,779,112
Ensembl chr 6:159,762,045...159,779,112
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ACER2 |
alkaline ceramidase 2 |
increases expression |
ISO |
Amiodarone results in increased expression of ACER2 mRNA |
CTD |
PMID:25580480 |
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NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505
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ACLY |
ATP citrate lyase |
increases expression |
EXP ISO |
Amiodarone results in increased expression of ACLY mRNA |
CTD |
PMID:32084307 PMID:32535746 |
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NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542
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ACO1 |
aconitase 1 |
affects expression |
ISO |
Amiodarone affects the expression of ACO1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
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ACO2 |
aconitase 2 |
affects expression |
ISO |
Amiodarone affects the expression of ACO2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273
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ACOT1 |
acyl-CoA thioesterase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of ACOT1 mRNA |
CTD |
PMID:24489787 PMID:24535564 PMID:30685923 PMID:32084307 |
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NCBI chr14:73,490,933...73,543,796
Ensembl chr14:73,537,143...73,543,796
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ACOT12 |
acyl-CoA thioesterase 12 |
affects expression increases expression |
ISO |
Amiodarone affects the expression of ACOT12 mRNA Amiodarone results in increased expression of ACOT12 mRNA |
CTD |
PMID:19483382 PMID:24489787 |
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NCBI chr 5:81,308,609...81,394,134
Ensembl chr 5:81,329,996...81,394,179
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ACOT2 |
acyl-CoA thioesterase 2 |
increases expression |
ISO |
Amiodarone results in increased expression of ACOT2 mRNA |
CTD |
PMID:24489787 PMID:24535564 PMID:30685923 |
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NCBI chr14:73,567,620...73,575,658
Ensembl chr14:73,567,620...73,575,658
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ACOT4 |
acyl-CoA thioesterase 4 |
affects expression |
ISO |
Amiodarone affects the expression of ACOT4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr14:73,591,873...73,595,766
Ensembl chr14:73,591,873...73,595,766
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ACOT8 |
acyl-CoA thioesterase 8 |
increases expression |
EXP |
Amiodarone results in increased expression of ACOT8 mRNA |
CTD |
PMID:19774075 |
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NCBI chr20:45,841,721...45,857,392
Ensembl chr20:45,841,721...45,857,405
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ACOX1 |
acyl-CoA oxidase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of ACOX1 mRNA |
CTD |
PMID:15265979 PMID:30685923 |
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NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
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ACOX2 |
acyl-CoA oxidase 2 |
increases expression |
ISO |
Amiodarone results in increased expression of ACOX2 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 3:58,505,136...58,537,190
Ensembl chr 3:58,505,136...58,537,283
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ACSF3 |
acyl-CoA synthetase family member 3 |
increases expression |
EXP |
Amiodarone results in increased expression of ACSF3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:89,093,852...89,156,233
Ensembl chr16:89,088,375...89,164,121
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ACSL3 |
acyl-CoA synthetase long chain family member 3 |
increases expression |
ISO |
Amiodarone results in increased expression of ACSL3 mRNA |
CTD |
PMID:32084307 |
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NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
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ACSS2 |
acyl-CoA synthetase short chain family member 2 |
increases expression |
ISO |
Amiodarone results in increased expression of ACSS2 mRNA |
CTD |
PMID:24535564 PMID:32084307 |
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NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962
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ACTA2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Amiodarone results in increased expression of ACTA2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Amiodarone results in increased expression of ACTA2 protein]; SB 203580 inhibits the reaction [Amiodarone results in increased expression of ACTA2 mRNA]; SB 203580 inhibits the reaction [Amiodarone results in increased expression of ACTA2 protein] Amiodarone results in increased expression of ACTA2 mRNA; Amiodarone results in increased expression of ACTA2 protein |
CTD |
PMID:31071512 |
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NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
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ACTR3B |
actin related protein 3B |
increases expression |
EXP |
Amiodarone results in increased expression of ACTR3B mRNA |
CTD |
PMID:19774075 |
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NCBI chr 7:152,759,752...152,855,378
Ensembl chr 7:152,759,749...152,855,378
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ACVR1B |
activin A receptor type 1B |
increases expression |
EXP |
Amiodarone results in increased expression of ACVR1B mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078
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ACYP1 |
acylphosphatase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of ACYP1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr14:75,053,243...75,069,490
Ensembl chr14:75,053,237...75,069,483
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ADA2 |
adenosine deaminase 2 |
increases expression |
EXP |
Amiodarone results in increased expression of ADA2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:17,178,790...17,221,848
Ensembl chr22:17,178,790...17,258,235
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ADAM15 |
ADAM metallopeptidase domain 15 |
affects expression |
ISO |
Amiodarone affects the expression of ADAM15 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:155,051,316...155,062,775
Ensembl chr 1:155,050,566...155,062,775
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ADD1 |
adducin 1 |
affects expression |
ISO |
Amiodarone affects the expression of ADD1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 4:2,843,844...2,930,062
Ensembl chr 4:2,843,844...2,930,076
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ADGRD1 |
adhesion G protein-coupled receptor D1 |
increases expression |
EXP |
Amiodarone results in increased expression of ADGRD1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:130,953,907...131,141,469
Ensembl chr12:130,953,907...131,141,469
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ADGRF1 |
adhesion G protein-coupled receptor F1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ADGRF1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 6:46,997,708...47,042,332
Ensembl chr 6:46,997,708...47,042,350
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ADH4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
affects expression |
ISO |
Amiodarone affects the expression of ADH4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792
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ADM2 |
adrenomedullin 2 |
multiple interactions |
EXP |
ADM2 protein inhibits the reaction [Amiodarone results in decreased activity of CAT protein]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of CAT mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of GPX1 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 protein]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of SOD1 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of SOD2 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 protein]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B protein]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased activity of CAT protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of CAT mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of GPX1 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of SOD1 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of SOD2 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF mRNA]] |
CTD |
PMID:34434487 |
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NCBI chr22:50,481,543...50,486,437
Ensembl chr22:50,481,543...50,486,440
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ADORA3 |
adenosine A3 receptor |
increases expression |
EXP |
Amiodarone results in increased expression of ADORA3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
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ADRA2A |
adrenoceptor alpha 2A |
increases expression |
EXP |
Amiodarone results in increased expression of ADRA2A mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907
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ADRB1 |
adrenoceptor beta 1 |
decreases expression |
EXP |
Amiodarone results in decreased expression of ADRB1 protein |
CTD |
PMID:1653643 |
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NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
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G |
ADRB2 |
adrenoceptor beta 2 |
decreases expression |
EXP |
Amiodarone results in decreased expression of ADRB2 protein |
CTD |
PMID:1653643 |
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NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
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G |
ADRB3 |
adrenoceptor beta 3 |
multiple interactions |
ISO |
Amiodarone inhibits the reaction [Triiodothyronine results in decreased expression of ADRB3 protein] |
CTD |
PMID:10217540 |
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NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
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ADTRP |
androgen dependent TFPI regulating protein |
affects expression |
ISO |
Amiodarone affects the expression of ADTRP mRNA |
CTD |
PMID:19483382 |
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NCBI chr 6:11,713,523...11,778,803
Ensembl chr 6:11,712,054...11,807,046
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AFM |
afamin |
affects expression |
ISO |
Amiodarone affects the expression of AFM mRNA |
CTD |
PMID:19483382 |
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NCBI chr 4:73,481,745...73,504,001
Ensembl chr 4:73,481,745...73,504,001
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AFP |
alpha fetoprotein |
increases expression |
ISO |
Amiodarone results in increased expression of AFP mRNA |
CTD |
PMID:24489787 |
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NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
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AGT |
angiotensinogen |
increases expression affects expression multiple interactions |
EXP ISO |
Amiodarone results in increased expression of AGT mRNA; Amiodarone results in increased expression of AGT protein Amiodarone affects the expression of AGT mRNA [FOS protein co-treated with JUN protein] promotes the reaction [Amiodarone results in increased expression of AGT mRNA]; Dactinomycin inhibits the reaction [Amiodarone results in increased expression of AGT mRNA] |
CTD |
PMID:17214612 PMID:19483382 |
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NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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G |
AGTR1 |
angiotensin II receptor type 1 |
affects expression |
ISO |
Amiodarone affects the expression of AGTR1A mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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G |
AHNAK |
AHNAK nucleoprotein |
increases expression |
EXP |
Amiodarone results in increased expression of AHNAK mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:62,433,544...62,546,806
Ensembl chr11:62,433,542...62,556,235
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G |
AHR |
aryl hydrocarbon receptor |
affects expression |
EXP |
Amiodarone affects the expression of AHR mRNA |
CTD |
PMID:35641671 |
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NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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G |
AIFM1 |
apoptosis inducing factor mitochondria associated 1 |
increases expression |
ISO |
Amiodarone results in increased expression of AIFM1 mRNA |
CTD |
PMID:24489787 |
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NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879
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G |
AK4 |
adenylate kinase 4 |
increases expression |
ISO |
Amiodarone results in increased expression of AK4 protein |
CTD |
PMID:16538043 |
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NCBI chr 1:65,147,552...65,232,145
Ensembl chr 1:65,147,549...65,232,145
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G |
AKR1A1 |
aldo-keto reductase family 1 member A1 |
affects expression |
ISO |
Amiodarone affects the expression of AKR1A1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049
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G |
AKR1C1 |
aldo-keto reductase family 1 member C1 |
increases expression |
EXP |
Amiodarone results in increased expression of AKR1C1 mRNA |
CTD |
PMID:21163907 |
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NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
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G |
AKR7A2 |
aldo-keto reductase family 7 member A2 |
affects expression |
ISO |
Amiodarone affects the expression of AKR7A2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144
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G |
AKR7A3 |
aldo-keto reductase family 7 member A3 |
affects expression |
ISO |
Amiodarone affects the expression of AKR7A3 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770
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G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
EXP ISO |
Amiodarone results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:23912912 PMID:26515726 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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G |
ALAS1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of ALAS1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
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G |
ALAS2 |
5'-aminolevulinate synthase 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ALAS2 mRNA |
CTD |
PMID:24535564 |
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NCBI chr X:55,009,055...55,030,977
Ensembl chr X:55,009,055...55,030,977
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G |
ALB |
albumin |
increases expression |
EXP |
Amiodarone results in increased expression of ALB mRNA |
CTD |
PMID:19774075 PMID:36586010 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
ALDH1A1 |
aldehyde dehydrogenase 1 family member A1 |
affects expression |
ISO |
Amiodarone affects the expression of ALDH1A1 mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
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G |
ALDH2 |
aldehyde dehydrogenase 2 family member |
affects expression |
ISO |
Amiodarone affects the expression of ALDH2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
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G |
ALDH3A2 |
aldehyde dehydrogenase 3 family member A2 |
increases expression |
ISO |
Amiodarone results in increased expression of ALDH3A2 mRNA |
CTD |
PMID:24535564 |
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NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760
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G |
ALDH6A1 |
aldehyde dehydrogenase 6 family member A1 |
increases expression |
ISO |
Amiodarone results in increased expression of ALDH6A1 mRNA |
CTD |
PMID:17991464 |
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NCBI chr14:74,056,847...74,084,453
Ensembl chr14:74,056,847...74,084,492
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G |
ALG12 |
ALG12 alpha-1,6-mannosyltransferase |
increases expression |
EXP |
Amiodarone results in increased expression of ALG12 mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:49,859,311...49,918,438
Ensembl chr22:49,900,229...49,918,438
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G |
ALG2 |
ALG2 alpha-1,3/1,6-mannosyltransferase |
increases expression |
EXP |
Amiodarone results in increased expression of ALG2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:99,216,425...99,221,942
Ensembl chr 9:99,216,425...99,221,942
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G |
ALK |
ALK receptor tyrosine kinase |
increases expression |
EXP |
Amiodarone results in increased expression of ALK mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:29,192,774...29,921,586
Ensembl chr 2:29,192,774...29,921,586
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G |
ALKAL1 |
ALK and LTK ligand 1 |
increases expression |
EXP |
Amiodarone results in increased expression of ALKAL1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:52,534,037...52,565,430
Ensembl chr 8:52,534,037...52,565,430
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G |
ALKBH7 |
alkB homolog 7 |
affects expression |
ISO |
Amiodarone affects the expression of ALKBH7 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:6,372,794...6,375,250
Ensembl chr19:6,372,794...6,375,250
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G |
AMIGO1 |
adhesion molecule with Ig like domain 1 |
increases expression |
EXP |
Amiodarone results in increased expression of AMIGO1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:109,504,178...109,509,727
Ensembl chr 1:109,504,178...109,509,738
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G |
ANGPTL3 |
angiopoietin like 3 |
decreases expression |
EXP |
Amiodarone results in decreased expression of ANGPTL3 mRNA |
CTD |
PMID:27089845 |
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NCBI chr 1:62,597,520...62,606,313
Ensembl chr 1:62,597,520...62,606,313
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G |
ANGPTL4 |
angiopoietin like 4 |
increases expression |
ISO |
Amiodarone results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:24489787 |
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NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370
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G |
ANXA4 |
annexin A4 |
increases expression |
EXP |
Amiodarone results in increased expression of ANXA4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
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G |
AOX3P |
aldehyde oxidase 3, pseudogene |
decreases expression |
ISO |
Amiodarone results in decreased expression of AOX3 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 2:200,695,723...200,738,781
Ensembl chr 2:200,678,233...200,732,539
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G |
AP1S1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression increases expression |
EXP |
Amiodarone results in decreased expression of AP1S1 mRNA Amiodarone results in increased expression of AP1S1 mRNA |
CTD |
PMID:17175557 PMID:17567588 PMID:29248575 |
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NCBI chr 7:101,154,476...101,161,276
Ensembl chr 7:101,154,456...101,161,596
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G |
AP2M1 |
adaptor related protein complex 2 subunit mu 1 |
affects expression |
ISO |
Amiodarone affects the expression of AP2M1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,214
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G |
APCS |
amyloid P component, serum |
affects expression |
ISO |
Amiodarone affects the expression of APCS mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:159,587,826...159,588,865
Ensembl chr 1:159,587,826...159,588,865
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G |
APOA4 |
apolipoprotein A4 |
affects expression |
ISO |
Amiodarone affects the expression of APOA4 mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
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G |
APOA5 |
apolipoprotein A5 |
increases expression |
ISO |
Amiodarone results in increased expression of APOA5 mRNA |
CTD |
PMID:24489787 |
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NCBI chr11:116,789,367...116,792,420
Ensembl chr11:116,789,367...116,792,420
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G |
APOB |
apolipoprotein B |
decreases expression |
EXP |
Amiodarone results in decreased expression of APOB mRNA |
CTD |
PMID:29248575 |
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NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
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G |
APOC2 |
apolipoprotein C2 |
increases expression |
ISO |
Amiodarone results in increased expression of APOC2 mRNA |
CTD |
PMID:24489787 |
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NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,946,035...44,949,565
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G |
APOE |
apolipoprotein E |
decreases expression |
ISO |
Amiodarone results in decreased expression of APOE mRNA |
CTD |
PMID:17991464 |
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NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
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G |
APOH |
apolipoprotein H |
affects expression |
ISO |
Amiodarone affects the expression of APOH mRNA |
CTD |
PMID:19483382 |
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NCBI chr17:66,212,033...66,229,415
Ensembl chr17:66,212,033...66,256,525
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G |
APOOL |
apolipoprotein O like |
affects expression |
ISO |
Amiodarone affects the expression of APOOL mRNA |
CTD |
PMID:19483382 |
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NCBI chr X:85,003,877...85,093,315
Ensembl chr X:85,003,877...85,093,315
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G |
ARC |
activity regulated cytoskeleton associated protein |
increases expression |
EXP |
Amiodarone results in increased expression of ARC mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
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G |
ARG1 |
arginase 1 |
affects expression |
ISO |
Amiodarone affects the expression of ARG1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
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G |
ARHGAP15 |
Rho GTPase activating protein 15 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGAP15 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:143,129,419...143,768,352
Ensembl chr 2:143,091,362...143,768,352
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G |
ARHGAP35 |
Rho GTPase activating protein 35 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGAP35 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:46,860,997...47,005,077
Ensembl chr19:46,860,997...47,005,077
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G |
ARHGAP4 |
Rho GTPase activating protein 4 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGAP4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:153,907,378...153,926,264
Ensembl chr X:153,907,367...153,934,999
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G |
ARHGAP45 |
Rho GTPase activating protein 45 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGAP45 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:1,065,959...1,086,628
Ensembl chr19:1,065,923...1,086,628
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G |
ARHGAP9 |
Rho GTPase activating protein 9 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGAP9 mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:57,472,269...57,488,824
Ensembl chr12:57,472,264...57,488,814
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G |
ARHGEF10L |
Rho guanine nucleotide exchange factor 10 like |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGEF10L mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:17,513,435...17,697,875
Ensembl chr 1:17,539,698...17,697,874
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G |
ARHGEF7 |
Rho guanine nucleotide exchange factor 7 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGEF7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737
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G |
ARHGEF9 |
Cdc42 guanine nucleotide exchange factor 9 |
increases expression |
EXP |
Amiodarone results in increased expression of ARHGEF9 mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:63,634,967...63,785,214
Ensembl chr X:63,634,967...63,809,274
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G |
ARID5A |
AT-rich interaction domain 5A |
increases expression |
EXP |
Amiodarone results in increased expression of ARID5A mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:96,536,752...96,552,638
Ensembl chr 2:96,536,743...96,552,638
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G |
ARL6IP1 |
ARL6 interacting reticulophagy regulator 1 |
affects expression |
ISO |
Amiodarone affects the expression of ARL6IP1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:18,791,667...18,801,549
Ensembl chr16:18,791,609...18,801,572
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G |
ARMC9 |
armadillo repeat containing 9 |
increases expression |
EXP |
Amiodarone results in increased expression of ARMC9 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:231,198,631...231,376,848
Ensembl chr 2:231,198,546...231,376,848
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G |
ARPC4 |
actin related protein 2/3 complex subunit 4 |
increases expression |
EXP |
Amiodarone results in increased expression of ARPC4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:9,792,518...9,807,101
Ensembl chr 3:9,792,495...9,807,101
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G |
ASAH1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO EXP |
Amiodarone results in increased expression of ASAH1 mRNA |
CTD |
PMID:15342952 PMID:17567588 PMID:19224547 |
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NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
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G |
ASB7 |
ankyrin repeat and SOCS box containing 7 |
increases expression |
EXP |
Amiodarone results in increased expression of ASB7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:100,602,589...100,651,701
Ensembl chr15:100,602,589...100,651,701
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G |
ASGR2 |
asialoglycoprotein receptor 2 |
affects expression |
ISO |
Amiodarone affects the expression of ASGR2 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr17:7,101,322...7,115,146
Ensembl chr17:7,101,322...7,115,700
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G |
ASNS |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
EXP |
Amiodarone results in increased expression of ASNS mRNA |
CTD |
PMID:17175557 PMID:17567588 PMID:36586010 |
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NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
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G |
ATF3 |
activating transcription factor 3 |
increases expression multiple interactions |
EXP ISO |
Amiodarone results in increased expression of ATF3 mRNA 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone promotes the reaction [Amiodarone results in increased expression of ATF3 mRNA] |
CTD |
PMID:19774075 PMID:34259586 PMID:36586010 |
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NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
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G |
ATF4 |
activating transcription factor 4 |
increases expression decreases expression multiple interactions |
EXP ISO |
Amiodarone results in increased expression of ATF4 mRNA; Amiodarone results in increased expression of ATF4 protein Amiodarone results in decreased expression of ATF4 mRNA 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of ATF4 mRNA] |
CTD |
PMID:21292685 PMID:28962527 PMID:34259586 PMID:35641671 PMID:36586010 |
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NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,686
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G |
ATF5 |
activating transcription factor 5 |
affects expression |
ISO |
Amiodarone affects the expression of ATF5 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr19:49,928,906...49,933,935
Ensembl chr19:49,928,702...49,933,935
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G |
ATF6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Amiodarone results in increased expression of and affects the localization of ATF6 protein |
CTD |
PMID:28962527 |
|
NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
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G |
ATF6B |
activating transcription factor 6 beta |
increases expression |
EXP |
Amiodarone results in increased expression of ATF6B mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253
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G |
ATG5 |
autophagy related 5 |
affects response to substance |
EXP |
ATG5 protein affects the susceptibility to Amiodarone |
CTD |
PMID:32651653 |
|
NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791
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G |
ATG7 |
autophagy related 7 |
increases expression affects response to substance multiple interactions |
EXP |
Amiodarone results in increased expression of ATG7 protein ATG7 protein affects the susceptibility to Amiodarone ATG7 protein affects the reaction [Amiodarone results in increased cleavage of CASP3 protein] |
CTD |
PMID:23912912 PMID:32651653 |
|
NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665
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G |
ATOH1 |
atonal bHLH transcription factor 1 |
increases expression |
EXP |
Amiodarone results in increased expression of ATOH1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 4:93,828,753...93,830,964
Ensembl chr 4:93,828,753...93,830,964
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G |
ATP11C |
ATPase phospholipid transporting 11C |
increases expression |
EXP |
Amiodarone results in increased expression of ATP11C mRNA |
CTD |
PMID:19774075 |
|
NCBI chr X:139,726,348...139,936,903
Ensembl chr X:139,726,346...139,945,276
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G |
ATP1A1 |
ATPase Na+/K+ transporting subunit alpha 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ATP1A1 protein |
CTD |
PMID:8071999 |
|
NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261
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G |
ATP1A2 |
ATPase Na+/K+ transporting subunit alpha 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ATP1A2 mRNA; Amiodarone results in decreased expression of ATP1A2 protein |
CTD |
PMID:7573397 PMID:8071999 PMID:12479229 |
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NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
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ATP1B1 |
ATPase Na+/K+ transporting subunit beta 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ATP1B1 protein |
CTD |
PMID:8071999 |
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NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992
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ATP1B2 |
ATPase Na+/K+ transporting subunit beta 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ATP1B2 mRNA |
CTD |
PMID:8071999 |
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NCBI chr17:7,646,627...7,657,770
Ensembl chr17:7,646,627...7,657,770
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ATP2A2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of ATP2A2 mRNA |
CTD |
PMID:17535870 |
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NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093
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ATP5F1B |
ATP synthase F1 subunit beta |
increases expression |
ISO |
Amiodarone results in increased expression of ATP5F1B mRNA |
CTD |
PMID:17991464 |
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NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984
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ATP5F1E |
ATP synthase F1 subunit epsilon |
affects expression |
ISO |
Amiodarone affects the expression of ATP5F1E mRNA |
CTD |
PMID:19483382 |
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NCBI chr20:59,025,475...59,032,335
Ensembl chr20:59,025,475...59,032,345
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ATP6AP2 |
ATPase H+ transporting accessory protein 2 |
affects expression |
ISO |
Amiodarone affects the expression of ATP6AP2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr X:40,580,970...40,606,848
Ensembl chr X:40,579,372...40,606,848
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ATP6V1A |
ATPase H+ transporting V1 subunit A |
affects expression |
ISO |
Amiodarone affects the expression of ATP6V1A mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:113,747,035...113,812,056
Ensembl chr 3:113,746,770...113,812,056
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ATP6V1F |
ATPase H+ transporting V1 subunit F |
affects expression |
ISO |
Amiodarone affects the expression of ATP6V1F mRNA |
CTD |
PMID:19483382 |
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NCBI chr 7:128,862,856...128,865,847
Ensembl chr 7:128,862,856...128,865,847
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BAAT |
bile acid-CoA:amino acid N-acyltransferase |
affects expression |
ISO |
Amiodarone affects the expression of BAAT mRNA |
CTD |
PMID:19483382 |
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NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400
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G |
BAG1 |
BAG cochaperone 1 |
increases expression |
EXP |
Amiodarone results in increased expression of BAG1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:33,252,471...33,264,708
Ensembl chr 9:33,247,820...33,264,720
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G |
BAG3 |
BAG cochaperone 3 |
decreases expression |
ISO |
Amiodarone results in decreased expression of BAG3 mRNA |
CTD |
PMID:17991464 |
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NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,380...119,677,819
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BAIAP2L1 |
BAR/IMD domain containing adaptor protein 2 like 1 |
increases expression |
EXP |
Amiodarone results in increased expression of BAIAP2L1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 7:98,291,650...98,401,090
Ensembl chr 7:98,291,650...98,401,090
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
Amiodarone results in increased expression of BAX mRNA; Amiodarone results in increased expression of BAX protein ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]] |
CTD |
PMID:12084619 PMID:34434487 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BBC3 |
BCL2 binding component 3 |
increases expression |
EXP |
Amiodarone results in increased expression of BBC3 mRNA |
CTD |
PMID:36586010 |
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NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
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BBOX1 |
gamma-butyrobetaine hydroxylase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of BBOX1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:27,040,815...27,127,809
Ensembl chr11:27,040,725...27,127,809
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BCKDHA |
branched chain keto acid dehydrogenase E1 subunit alpha |
increases expression |
ISO |
Amiodarone results in increased expression of BCKDHA protein |
CTD |
PMID:16538043 |
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NCBI chr19:41,397,818...41,425,002
Ensembl chr19:41,397,808...41,425,002
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BCL2 |
BCL2 apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Amiodarone results in decreased expression of BCL2 protein Amiodarone results in decreased expression of BCL2 mRNA; Amiodarone results in decreased expression of BCL2 protein [3-methyladenine co-treated with Amiodarone] results in decreased expression of BCL2 protein; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]] |
CTD |
PMID:21224497 PMID:23912912 PMID:34434487 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BCL2L11 |
BCL2 like 11 |
increases expression |
EXP |
Amiodarone results in increased expression of BCL2L11 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444
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G |
BCL3 |
BCL3 transcription coactivator |
increases expression |
ISO |
Amiodarone results in increased expression of BCL3 mRNA |
CTD |
PMID:22015988 |
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NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044
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G |
BCL6B |
BCL6B transcription repressor |
affects expression |
ISO |
Amiodarone affects the expression of BCL6B mRNA |
CTD |
PMID:19483382 |
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NCBI chr17:7,023,050...7,029,644
Ensembl chr17:7,023,050...7,030,290
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G |
BCO1 |
beta-carotene oxygenase 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of BCO1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr16:81,238,689...81,291,142
Ensembl chr16:81,238,689...81,291,142
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G |
BDNF |
brain derived neurotrophic factor |
affects expression |
ISO |
Amiodarone affects the expression of BDNF mRNA |
CTD |
PMID:31324950 |
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NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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G |
BHLHE40 |
basic helix-loop-helix family member e40 |
increases expression |
EXP |
Amiodarone results in increased expression of BHLHE40 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:4,979,437...4,985,323
Ensembl chr 3:4,979,437...4,985,323
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G |
BHMT |
betaine--homocysteine S-methyltransferase |
affects expression |
ISO |
Amiodarone affects the expression of BHMT mRNA |
CTD |
PMID:18355885 |
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NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
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G |
BID |
BH3 interacting domain death agonist |
multiple interactions |
EXP |
[TNFSF10 co-treated with Amiodarone] results in increased cleavage of BID protein |
CTD |
PMID:21292685 |
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NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
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G |
BIRC5 |
baculoviral IAP repeat containing 5 |
decreases expression |
ISO |
Amiodarone results in decreased expression of BIRC5 protein |
CTD |
PMID:21224497 |
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NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
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G |
BLTP3B |
bridge-like lipid transfer protein family member 3B |
affects expression |
ISO |
Amiodarone affects the expression of BLTP3B mRNA |
CTD |
PMID:19483382 |
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NCBI chr12:100,037,072...100,142,874
Ensembl chr12:100,028,455...100,142,874
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BMF |
Bcl2 modifying factor |
affects expression |
ISO |
Amiodarone affects the expression of BMF mRNA |
CTD |
PMID:19483382 |
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NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892
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G |
BMP2K |
BMP2 inducible kinase |
increases expression |
EXP |
Amiodarone results in increased expression of BMP2K mRNA |
CTD |
PMID:19774075 |
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NCBI chr 4:78,776,350...78,916,365
Ensembl chr 4:78,776,342...78,916,365
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G |
BNIP3 |
BCL2 interacting protein 3 |
affects expression |
ISO |
Amiodarone affects the expression of BNIP3 mRNA |
CTD |
PMID:19483382 |
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NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
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G |
BOLA2 |
bolA family member 2 |
increases expression |
EXP |
Amiodarone results in increased expression of BOLA2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:29,453,588...29,454,964
Ensembl chr16:30,192,932...30,194,306 Ensembl chr16:30,192,932...30,194,306
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BOLL |
boule homolog, RNA binding protein |
increases expression |
EXP |
Amiodarone results in increased expression of BOLL mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:197,726,890...197,786,206
Ensembl chr 2:197,726,879...197,786,762
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G |
BRCA1 |
BRCA1 DNA repair associated |
increases expression |
ISO |
Amiodarone results in increased expression of BRCA1 mRNA |
CTD |
PMID:24489787 |
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NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245
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G |
BRCC3 |
BRCA1/BRCA2-containing complex subunit 3 |
increases expression |
EXP |
Amiodarone results in increased expression of BRCC3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:155,071,508...155,123,077
Ensembl chr X:155,071,420...155,123,077
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G |
BRPF1 |
bromodomain and PHD finger containing 1 |
increases expression |
EXP |
Amiodarone results in increased expression of BRPF1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:9,731,735...9,748,015
Ensembl chr 3:9,731,729...9,748,019
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BSG |
basigin (Ok blood group) |
increases expression |
EXP |
Amiodarone results in increased expression of BSG mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,494
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G |
BTF3 |
basic transcription factor 3 |
affects expression |
ISO |
Amiodarone affects the expression of BTF3 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 5:73,498,442...73,505,667
Ensembl chr 5:73,498,408...73,505,667
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G |
C11orf16 |
chromosome 11 open reading frame 16 |
increases expression |
EXP |
Amiodarone results in increased expression of C11ORF16 mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:8,920,076...8,932,947
Ensembl chr11:8,920,076...8,933,006
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C16orf74 |
chromosome 16 open reading frame 74 |
increases expression |
EXP |
Amiodarone results in increased expression of C16ORF74 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:85,707,517...85,751,096
Ensembl chr16:85,690,084...85,751,129
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G |
C1QBP |
complement C1q binding protein |
affects expression |
ISO |
Amiodarone affects the expression of C1QBP mRNA |
CTD |
PMID:19483382 |
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NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830
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C1S |
complement C1s |
affects expression |
ISO |
Amiodarone affects the expression of C1S mRNA |
CTD |
PMID:19483382 |
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NCBI chr12:7,060,718...7,071,032
Ensembl chr12:6,988,259...7,071,032
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C21orf91 |
chromosome 21 open reading frame 91 |
increases expression |
EXP |
Amiodarone results in increased expression of C21ORF91 mRNA |
CTD |
PMID:19774075 |
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NCBI chr21:17,788,974...17,819,356
Ensembl chr21:17,788,974...17,819,386
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C2CD2 |
C2 calcium dependent domain containing 2 |
affects expression |
ISO |
Amiodarone affects the expression of C2CD2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr21:41,885,112...41,954,018
Ensembl chr21:41,885,112...41,954,018
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C2CD4B |
C2 calcium dependent domain containing 4B |
increases expression |
EXP |
Amiodarone results in increased expression of NLF2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:62,163,535...62,165,285
Ensembl chr15:62,163,535...62,165,285
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G |
C3orf18 |
chromosome 3 open reading frame 18 |
increases expression |
EXP |
Amiodarone results in increased expression of C3ORF18 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:50,558,025...50,574,700
Ensembl chr 3:50,558,025...50,571,027
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C3orf33 |
chromosome 3 open reading frame 33 |
increases expression |
EXP |
Amiodarone results in increased expression of C3ORF33 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:155,762,617...155,806,278
Ensembl chr 3:155,762,617...155,806,278
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G |
C4BPA |
complement component 4 binding protein alpha |
affects expression |
ISO |
Amiodarone affects the expression of C4BPA mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:207,104,233...207,144,972
Ensembl chr 1:207,104,233...207,144,972
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C6orf141 |
chromosome 6 open reading frame 141 |
increases expression |
EXP |
Amiodarone results in increased expression of C6ORF141 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:49,550,668...49,561,916
Ensembl chr 6:49,550,666...49,561,907
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C7 |
complement C7 |
affects expression |
ISO |
Amiodarone affects the expression of C7 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,492...41,020,216
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C8B |
complement C8 beta chain |
affects expression decreases expression |
ISO |
Amiodarone affects the expression of C8B mRNA Amiodarone results in decreased expression of C8B mRNA |
CTD |
PMID:19483382 PMID:24535564 |
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NCBI chr 1:56,929,207...56,966,015
Ensembl chr 1:56,929,207...56,974,383
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CA2 |
carbonic anhydrase 2 |
affects expression |
ISO |
Amiodarone affects the expression of CA2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
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G |
CA3 |
carbonic anhydrase 3 |
affects expression increases expression |
ISO |
Amiodarone affects the expression of CAR3 mRNA Amiodarone results in increased expression of CAR3 protein |
CTD |
PMID:16538043 PMID:19483382 |
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NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
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CACNA1C |
calcium voltage-gated channel subunit alpha1 C |
decreases expression |
ISO |
Amiodarone results in decreased expression of CACNA1C mRNA |
CTD |
PMID:15520326 |
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NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950
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CADPS2 |
calcium dependent secretion activator 2 |
affects expression |
ISO |
Amiodarone affects the expression of CADPS2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 7:122,318,411...122,886,460
Ensembl chr 7:122,318,411...122,886,759
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CALR |
calreticulin |
increases expression |
EXP |
Amiodarone results in increased expression of CALR mRNA |
CTD |
PMID:36586010 |
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NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489
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G |
CAMK2A |
calcium/calmodulin dependent protein kinase II alpha |
increases expression |
EXP |
Amiodarone results in increased expression of CAMK2A mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
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CAPN11 |
calpain 11 |
increases expression |
EXP |
Amiodarone results in increased expression of CAPN11 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:44,158,820...44,184,401
Ensembl chr 6:44,158,811...44,184,401
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CAPN3 |
calpain 3 |
increases expression |
EXP |
Amiodarone results in increased expression of CAPN3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:42,359,501...42,412,317
Ensembl chr15:42,359,498...42,412,949
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CAPRIN1 |
cell cycle associated protein 1 |
affects expression |
ISO |
Amiodarone affects the expression of CAPRIN1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr11:34,051,731...34,102,610
Ensembl chr11:34,051,731...34,102,610
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G |
CARD9 |
caspase recruitment domain family member 9 |
increases expression |
EXP |
Amiodarone results in increased expression of CARD9 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:136,363,956...136,373,669
Ensembl chr 9:136,363,956...136,373,681
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CASKIN2 |
CASK interacting protein 2 |
increases expression |
EXP |
Amiodarone results in increased expression of CASKIN2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:75,500,261...75,515,537
Ensembl chr17:75,500,261...75,515,537
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G |
CASP3 |
caspase 3 |
affects expression increases cleavage increases activity increases expression decreases expression multiple interactions |
ISO EXP |
Amiodarone affects the expression of CASP3 mRNA Amiodarone results in increased cleavage of CASP3 protein Amiodarone results in increased activity of CASP3 protein Amiodarone results in increased expression of CASP3 mRNA Amiodarone results in decreased expression of CASP3 protein modified form 3-methyladenine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; [TNFSF10 co-treated with Amiodarone] results in increased cleavage of CASP3 protein; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; Amiodarone results in increased activity of and results in increased cleavage of CASP3 protein; ATG7 protein affects the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]]; TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein] Amiodarone results in increased expression of CASP3 mRNA; Amiodarone results in increased expression of CASP3 protein |
CTD |
PMID:12084619 PMID:12747577 PMID:19483382 PMID:19815060 PMID:21224497 PMID:21292685 PMID:23042730 PMID:23135547 PMID:23912912 PMID:28526448 PMID:32651653 PMID:34434487 More...
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP7 |
caspase 7 |
multiple interactions increases expression increases activity |
EXP ISO |
alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]; TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein] Amiodarone results in increased expression of CASP7 mRNA |
CTD |
PMID:23042730 PMID:23135547 PMID:24489787 |
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NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
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G |
CASP8 |
caspase 8 |
multiple interactions increases expression |
EXP ISO |
[TNFSF10 co-treated with Amiodarone] results in increased cleavage of CASP8 protein Amiodarone results in increased expression of CASP8 protein modified form |
CTD |
PMID:21224497 PMID:21292685 |
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NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
CASP9 |
caspase 9 |
increases expression multiple interactions |
EXP ISO |
Amiodarone results in increased expression of CASP9 mRNA [Amiodarone co-treated with TNF protein] results in increased activity of CASP9 protein [TNFSF10 co-treated with Amiodarone] results in increased cleavage of CASP9 protein |
CTD |
PMID:19774075 PMID:21292685 PMID:23042730 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CAT |
catalase |
multiple interactions decreases expression decreases activity |
ISO EXP |
Amiodarone inhibits the reaction [Indomethacin results in increased activity of CAT protein] ADM2 protein inhibits the reaction [Amiodarone results in decreased activity of CAT protein]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of CAT mRNA]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased activity of CAT protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of CAT mRNA]] |
CTD |
PMID:18087811 PMID:34434487 |
|
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CAV3 |
caveolin 3 |
increases expression |
EXP |
Amiodarone results in increased expression of CAV3 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 3:8,733,802...8,746,758
Ensembl chr 3:8,733,802...8,841,808
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CBR1 |
carbonyl reductase 1 |
affects expression |
ISO |
Amiodarone affects the expression of CBR1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
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G |
CCDC134 |
coiled-coil domain containing 134 |
increases expression |
EXP |
Amiodarone results in increased expression of CCDC134 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr22:41,800,679...41,832,164
Ensembl chr22:41,800,679...41,832,164
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G |
CCDC17 |
coiled-coil domain containing 17 |
increases expression |
EXP |
Amiodarone results in increased expression of CCDC17 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:45,620,044...45,624,054
Ensembl chr 1:45,620,044...45,624,057
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G |
CCDC197 |
coiled-coil domain containing 197 |
increases expression |
EXP |
Amiodarone results in increased expression of CCDC197 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr14:93,987,225...94,011,695
Ensembl chr14:93,987,225...94,008,863
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G |
CCDC9 |
coiled-coil domain containing 9 |
increases expression |
EXP |
Amiodarone results in increased expression of CCDC9 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr19:47,256,525...47,275,723
Ensembl chr19:47,255,980...47,273,701
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G |
CCL2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
EXP ISO |
Amiodarone inhibits the reaction [CRP protein results in increased expression of CCL2 protein] [Amiodarone co-treated with Dexamethasone] results in increased expression of CCL2 mRNA Amiodarone results in increased expression of CCL2 mRNA |
CTD |
PMID:19225199 PMID:23397585 PMID:25900201 |
|
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CCN2 |
cellular communication network factor 2 |
increases expression |
ISO |
Amiodarone results in increased expression of CCN2 mRNA |
CTD |
PMID:32909452 |
|
NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
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G |
CCNT1 |
cyclin T1 |
increases expression |
EXP |
Amiodarone results in increased expression of CCNT1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998
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G |
CCR9 |
C-C motif chemokine receptor 9 |
increases expression |
EXP |
Amiodarone results in increased expression of CCR9 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 3:45,886,064...45,903,174
Ensembl chr 3:45,884,425...45,903,174
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G |
CD320 |
CD320 molecule |
increases expression |
EXP |
Amiodarone results in increased expression of CD320 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:8,302,127...8,308,358
Ensembl chr19:8,302,127...8,308,358
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G |
CD36 |
CD36 molecule (CD36 blood group) |
increases expression decreases expression |
ISO EXP |
Amiodarone results in increased expression of CD36 mRNA; Amiodarone results in increased expression of CD36 protein Amiodarone results in decreased expression of CD36 mRNA |
CTD |
PMID:24535564 PMID:29248575 PMID:32535746 PMID:34259586 |
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NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
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G |
CD86 |
CD86 molecule |
multiple interactions |
EXP |
[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CD86 protein |
CTD |
PMID:22785256 |
|
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
CDA |
cytidine deaminase |
increases expression |
ISO |
Amiodarone results in increased expression of CDA mRNA |
CTD |
PMID:24535564 |
|
NCBI chr 1:20,589,097...20,618,903
Ensembl chr 1:20,589,086...20,618,903
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G |
CDC25A |
cell division cycle 25A |
increases expression |
EXP |
Amiodarone results in increased expression of CDC25A mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
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G |
CDC42SE1 |
CDC42 small effector 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CDC42SE1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:151,050,985...151,059,622
Ensembl chr 1:151,050,971...151,070,325
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G |
CDH1 |
cadherin 1 |
increases expression multiple interactions |
ISO EXP |
Amiodarone results in increased expression of CDH1 protein 6-bromoindirubin-3'-oxime inhibits the reaction [Amiodarone results in increased expression of CDH1 protein] |
CTD |
PMID:26515726 |
|
NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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G |
CDH15 |
cadherin 15 |
increases expression |
EXP |
Amiodarone results in increased expression of CDH15 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr16:89,171,748...89,195,492
Ensembl chr16:89,171,748...89,195,492
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G |
CDH2 |
cadherin 2 |
decreases expression |
ISO EXP |
Amiodarone results in decreased expression of CDH2 protein |
CTD |
PMID:26515726 |
|
NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946
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G |
CDH26 |
cadherin 26 |
increases expression |
EXP |
Amiodarone results in increased expression of CDH26 mRNA |
CTD |
PMID:19774075 |
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NCBI chr20:59,958,423...60,035,934
Ensembl chr20:59,958,423...60,034,011
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G |
CDK17 |
cyclin dependent kinase 17 |
increases expression |
EXP |
Amiodarone results in increased expression of CDK17 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr12:96,278,225...96,400,439
Ensembl chr12:96,278,261...96,400,480
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G |
CDKN2C |
cyclin dependent kinase inhibitor 2C |
affects expression |
ISO |
Amiodarone affects the expression of CDKN2C mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 1:50,960,745...50,974,634
Ensembl chr 1:50,960,745...50,974,634
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G |
CDO1 |
cysteine dioxygenase type 1 |
affects expression |
ISO |
Amiodarone affects the expression of CDO1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 5:115,804,733...115,816,659
Ensembl chr 5:115,804,733...115,816,659
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G |
CEBPB |
CCAAT enhancer binding protein beta |
increases expression |
EXP ISO |
Amiodarone results in increased expression of CEBPB mRNA |
CTD |
PMID:19774075 PMID:25580480 |
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NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,734...50,192,690
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G |
CELF6 |
CUGBP Elav-like family member 6 |
increases expression |
EXP |
Amiodarone results in increased expression of CELF6 mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:72,284,727...72,320,157
Ensembl chr15:72,284,727...72,320,157
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G |
CEPT1 |
choline/ethanolamine phosphotransferase 1 |
affects expression |
ISO |
Amiodarone affects the expression of CEPT1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:111,139,499...111,185,104
Ensembl chr 1:111,139,479...111,185,104
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G |
CES1 |
carboxylesterase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CES1 mRNA |
CTD |
PMID:21163907 |
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NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337
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G |
CES2 |
carboxylesterase 2 |
affects expression |
ISO |
Amiodarone affects the expression of CES2 mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
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G |
CFAP184 |
cilia and flagella associated protein 184 |
increases expression |
EXP |
Amiodarone results in increased expression of CFAP184 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 4:7,040,849...7,043,001
Ensembl chr 4:7,040,849...7,043,001
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G |
CFI |
complement factor I |
affects expression |
ISO |
Amiodarone affects the expression of CFI mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 4:109,730,982...109,801,999
Ensembl chr 4:109,731,008...109,802,150
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G |
CFLAR |
CASP8 and FADD like apoptosis regulator |
decreases expression |
ISO |
Amiodarone results in decreased expression of CFLAR protein |
CTD |
PMID:21224497 |
|
NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
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G |
CGA |
glycoprotein hormones, alpha polypeptide |
increases expression |
ISO |
Amiodarone results in increased expression of CGA mRNA |
CTD |
PMID:3427795 |
|
NCBI chr 6:87,085,498...87,095,106
Ensembl chr 6:87,085,498...87,095,106
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G |
CHAC1 |
ChaC glutathione specific gamma-glutamylcyclotransferase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CHAC1 mRNA |
CTD |
PMID:19774075 PMID:36586010 |
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NCBI chr15:40,953,471...40,956,512
Ensembl chr15:40,952,962...40,956,512
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G |
CHAF1A |
chromatin assembly factor 1 subunit A |
decreases expression |
ISO |
Amiodarone results in decreased expression of CHAF1A mRNA |
CTD |
PMID:17991464 |
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NCBI chr19:4,402,640...4,450,830
Ensembl chr19:4,402,640...4,445,018
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G |
CHAT |
choline O-acetyltransferase |
decreases expression |
ISO |
Amiodarone results in decreased expression of CHAT protein |
CTD |
PMID:25659768 |
|
NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CHGA |
chromogranin A |
increases expression |
EXP |
Amiodarone results in increased expression of CHGA mRNA |
CTD |
PMID:19774075 |
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NCBI chr14:92,922,664...92,935,285
Ensembl chr14:92,923,150...92,935,285
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G |
CHP1 |
calcineurin like EF-hand protein 1 |
affects expression |
ISO |
Amiodarone affects the expression of CHP1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr15:41,231,268...41,281,887
Ensembl chr15:41,230,839...41,281,887
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G |
CHRNB3 |
cholinergic receptor nicotinic beta 3 subunit |
increases expression |
EXP |
Amiodarone results in increased expression of CHRNB3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:42,697,366...42,737,407
Ensembl chr 8:42,697,366...42,737,407
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G |
CHST6 |
carbohydrate sulfotransferase 6 |
increases expression |
EXP |
Amiodarone results in increased expression of CHST6 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:75,472,042...75,495,441
Ensembl chr16:75,472,052...75,495,445
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G |
CIDEA |
cell death inducing DFFA like effector a |
multiple interactions increases expression |
ISO |
1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of CIDEA mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEA mRNA] |
CTD |
PMID:28962527 |
|
NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595
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G |
CIDEC |
cell death inducing DFFA like effector c |
increases expression multiple interactions |
ISO |
Amiodarone results in increased expression of CIDEC mRNA; Amiodarone results in increased expression of CIDEC protein 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEC protein] |
CTD |
PMID:28962527 |
|
NCBI chr 3:9,866,710...9,880,253
Ensembl chr 3:9,866,711...9,880,255
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G |
CIMAP3 |
ciliary microtubule associated protein 3 |
increases expression |
EXP |
Amiodarone results in increased expression of CIMAP3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:111,324,663...111,353,017
Ensembl chr 1:111,346,600...111,353,013
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G |
CISD1 |
CDGSH iron sulfur domain 1 |
affects expression |
ISO |
Amiodarone affects the expression of CISD1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr10:58,269,162...58,289,586
Ensembl chr10:58,269,162...58,289,586
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G |
CLCN4 |
chloride voltage-gated channel 4 |
affects expression |
ISO |
Amiodarone affects the expression of CLCN4 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr X:10,156,975...10,237,660
Ensembl chr X:10,156,975...10,237,660
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G |
CLCN5 |
chloride voltage-gated channel 5 |
increases expression |
EXP |
Amiodarone results in increased expression of CLCN5 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr X:49,922,596...50,099,230
Ensembl chr X:49,922,596...50,099,235
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G |
CLCN6 |
chloride voltage-gated channel 6 |
increases expression |
EXP |
Amiodarone results in increased expression of CLCN6 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:11,806,191...11,843,130
Ensembl chr 1:11,806,096...11,848,079
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G |
CLPP |
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
affects expression |
ISO |
Amiodarone affects the expression of CLPP mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:6,361,531...6,370,242
Ensembl chr19:6,361,427...6,370,242
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G |
CLPTM1L |
CLPTM1 like |
affects expression |
ISO |
Amiodarone affects the expression of CLPTM1L mRNA |
CTD |
PMID:19483382 |
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NCBI chr 5:1,317,752...1,345,099
Ensembl chr 5:1,317,752...1,345,099
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G |
CLPX |
caseinolytic mitochondrial matrix peptidase chaperone subunit X |
increases expression |
ISO |
Amiodarone results in increased expression of CLPX mRNA |
CTD |
PMID:24535564 |
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NCBI chr15:65,148,219...65,185,342
Ensembl chr15:65,148,219...65,185,342
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G |
CLTCL1 |
clathrin heavy chain like 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CLTCL1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:19,179,473...19,291,719
Ensembl chr22:19,179,473...19,291,719
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G |
CLVS2 |
clavesin 2 |
increases expression |
EXP |
Amiodarone results in increased expression of CLVS2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:122,996,235...123,072,925
Ensembl chr 6:122,996,235...123,072,925
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G |
CMBL |
carboxymethylenebutenolidase homolog |
affects expression increases expression |
ISO |
Amiodarone affects the expression of CMBL mRNA Amiodarone results in increased expression of CMBL mRNA |
CTD |
PMID:19483382 PMID:24535564 |
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NCBI chr 5:10,277,595...10,307,902
Ensembl chr 5:10,275,875...10,307,902
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G |
CMPK1 |
cytidine/uridine monophosphate kinase 1 |
affects expression |
ISO |
Amiodarone affects the expression of CMPK1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,790...47,394,866
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G |
CMTM6 |
CKLF like MARVEL transmembrane domain containing 6 |
affects expression |
ISO |
Amiodarone affects the expression of CMTM6 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 3:32,481,312...32,502,852
Ensembl chr 3:32,481,312...32,502,852
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G |
CMTM7 |
CKLF like MARVEL transmembrane domain containing 7 |
increases expression |
EXP |
Amiodarone results in increased expression of CMTM7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:32,391,853...32,455,528
Ensembl chr 3:32,391,698...32,483,067
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G |
CMYA5 |
cardiomyopathy associated 5 |
increases expression |
EXP |
Amiodarone results in increased expression of CMYA5 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:79,689,836...79,800,222
Ensembl chr 5:79,689,836...79,800,240
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G |
CNIH3 |
cornichon family AMPA receptor auxiliary protein 3 |
increases expression |
EXP |
Amiodarone results in increased expression of CNIH3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:224,434,640...224,740,554
Ensembl chr 1:224,434,660...224,740,554
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G |
CNNM2 |
cyclin and CBS domain divalent metal cation transport mediator 2 |
increases expression |
EXP |
Amiodarone results in increased expression of CNNM2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr10:102,918,294...103,090,222
Ensembl chr10:102,918,294...103,090,222
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G |
CNOT7 |
CCR4-NOT transcription complex subunit 7 |
increases expression |
EXP |
Amiodarone results in increased expression of CNOT7 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 8:17,224,966...17,246,857
Ensembl chr 8:17,224,966...17,246,878
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G |
CNP |
2',3'-cyclic nucleotide 3' phosphodiesterase |
increases expression |
EXP |
Amiodarone results in increased expression of CNP mRNA |
CTD |
PMID:19774075 |
|
NCBI chr17:41,966,795...41,977,740
Ensembl chr17:41,966,763...41,977,740
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G |
COL11A1 |
collagen type XI alpha 1 chain |
increases expression |
EXP |
Amiodarone results in increased expression of COL11A1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872
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G |
COL1A1 |
collagen type I alpha 1 chain |
increases expression |
ISO |
Amiodarone results in increased expression of COL1A1 mRNA |
CTD |
PMID:32909452 |
|
NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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G |
COL27A1 |
collagen type XXVII alpha 1 chain |
increases expression |
EXP |
Amiodarone results in increased expression of COL27A1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 9:114,154,098...114,312,511
Ensembl chr 9:114,155,537...114,312,511
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G |
COL8A2 |
collagen type VIII alpha 2 chain |
increases expression |
EXP |
Amiodarone results in increased expression of COL8A2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:36,095,239...36,125,222
Ensembl chr 1:36,095,239...36,125,222
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G |
COPG1 |
COPI coat complex subunit gamma 1 |
affects expression |
ISO |
Amiodarone affects the expression of COPG1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 3:129,249,606...129,277,773
Ensembl chr 3:129,249,606...129,277,773
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G |
COPS4 |
COP9 signalosome subunit 4 |
affects expression |
ISO |
Amiodarone affects the expression of COPS4 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 4:83,035,183...83,075,818
Ensembl chr 4:83,034,447...83,075,818
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G |
COPZ2 |
COPI coat complex subunit zeta 2 |
increases expression |
ISO |
Amiodarone results in increased expression of COPZ2 mRNA |
CTD |
PMID:24535564 |
|
NCBI chr17:48,026,167...48,048,053
Ensembl chr17:48,026,167...48,038,030
|
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G |
COQ2 |
coenzyme Q2, polyprenyltransferase |
increases expression |
ISO |
Amiodarone results in increased expression of COQ2 mRNA |
CTD |
PMID:24489787 |
|
NCBI chr 4:83,263,824...83,285,134
Ensembl chr 4:83,261,536...83,284,914
|
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G |
COQ3 |
coenzyme Q3, methyltransferase |
affects expression increases expression |
ISO |
Amiodarone affects the expression of COQ3 mRNA Amiodarone results in increased expression of COQ3 mRNA |
CTD |
PMID:19483382 PMID:24489787 |
|
NCBI chr 6:99,369,401...99,394,195
Ensembl chr 6:99,369,401...99,394,195
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G |
CORO2A |
coronin 2A |
increases expression |
EXP |
Amiodarone results in increased expression of CORO2A mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 9:98,120,975...98,192,637
Ensembl chr 9:98,120,975...98,192,637
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G |
CORT |
cortistatin |
affects expression |
ISO |
Amiodarone affects the expression of CORT mRNA |
CTD |
PMID:31324950 |
|
NCBI chr 1:10,450,031...10,451,998
Ensembl chr 1:10,450,031...10,451,998
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G |
COX15 |
cytochrome c oxidase assembly homolog COX15 |
increases expression |
ISO |
Amiodarone results in increased expression of COX15 mRNA |
CTD |
PMID:24489787 |
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NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127
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G |
COX17 |
cytochrome c oxidase copper chaperone COX17 |
increases expression |
ISO |
Amiodarone results in increased expression of COX17 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 3:119,663,975...119,677,406
Ensembl chr 3:119,654,513...119,677,454
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G |
COX4I1 |
cytochrome c oxidase subunit 4I1 |
affects expression |
ISO |
Amiodarone affects the expression of COX4I1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
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G |
COX6B2 |
cytochrome c oxidase subunit 6B2 |
increases expression |
ISO |
Amiodarone results in increased expression of COX6B2 mRNA |
CTD |
PMID:24535564 |
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NCBI chr19:55,349,704...55,354,719
Ensembl chr19:55,349,306...55,354,719
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G |
CPLX2 |
complexin 2 |
increases expression |
EXP |
Amiodarone results in increased expression of CPLX2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:175,796,533...175,884,021
Ensembl chr 5:175,796,310...175,884,021
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G |
CPN1 |
carboxypeptidase N subunit 1 |
affects expression |
ISO |
Amiodarone affects the expression of CPN1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr10:100,042,193...100,081,869
Ensembl chr10:100,042,193...100,081,869
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G |
CPPED1 |
calcineurin like phosphoesterase domain containing 1 |
affects expression |
ISO |
Amiodarone affects the expression of CPPED1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr16:12,659,799...12,803,887
Ensembl chr16:12,659,799...12,803,887
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G |
CPQ |
carboxypeptidase Q |
affects expression |
ISO |
Amiodarone affects the expression of CPQ mRNA |
CTD |
PMID:19483382 |
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NCBI chr 8:96,645,242...97,143,501
Ensembl chr 8:96,645,242...97,149,654
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G |
CPT1A |
carnitine palmitoyltransferase 1A |
increases expression decreases expression affects expression |
ISO EXP |
Amiodarone results in increased expression of CPT1A mRNA Amiodarone results in decreased expression of CPT1A mRNA Amiodarone affects the expression of CPT1A mRNA |
CTD |
PMID:24489787 PMID:29248575 PMID:32084307 |
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NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
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G |
CPT2 |
carnitine palmitoyltransferase 2 |
increases expression decreases expression |
ISO |
Amiodarone results in increased expression of CPT2 mRNA Amiodarone results in decreased expression of CPT2 mRNA |
CTD |
PMID:24489787 PMID:30685923 PMID:32084307 |
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NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197
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G |
CRB3 |
crumbs cell polarity complex component 3 |
increases expression |
EXP |
Amiodarone results in increased expression of CRB3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:6,463,777...6,467,221
Ensembl chr19:6,463,777...6,467,221
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G |
CREM |
cAMP responsive element modulator |
affects expression |
ISO |
Amiodarone affects the expression of CREM mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958
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G |
CROT |
carnitine O-octanoyltransferase |
decreases expression |
EXP |
Amiodarone results in decreased expression of CROT mRNA |
CTD |
PMID:27089845 |
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NCBI chr 7:87,345,664...87,399,794
Ensembl chr 7:87,345,664...87,399,794
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G |
CRP |
C-reactive protein |
multiple interactions |
EXP |
Amiodarone inhibits the reaction [CRP protein results in increased expression of CCL2 protein]; Amiodarone inhibits the reaction [CRP protein results in increased expression of TNF protein] |
CTD |
PMID:19225199 |
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NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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G |
CRTC1 |
CREB regulated transcription coactivator 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of CRTC1 mRNA |
CTD |
PMID:17991464 |
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NCBI chr19:18,683,680...18,782,333
Ensembl chr19:18,683,678...18,782,333
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G |
CSNK2B |
casein kinase 2 beta |
affects expression |
ISO |
Amiodarone affects the expression of CSNK2B mRNA |
CTD |
PMID:19483382 |
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NCBI chr 6:31,666,080...31,670,067
Ensembl chr 6:31,665,227...31,670,343
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G |
CSRP1 |
cysteine and glycine rich protein 1 |
affects expression |
ISO |
Amiodarone affects the expression of CSRP1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:201,483,530...201,507,123
Ensembl chr 1:201,483,530...201,509,456
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G |
CSRP3 |
cysteine and glycine rich protein 3 |
increases expression |
ISO |
Amiodarone results in increased expression of CSRP3 mRNA |
CTD |
PMID:24535564 |
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NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
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G |
CST6 |
cystatin E/M |
increases expression |
EXP |
Amiodarone results in increased expression of CST6 mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:66,012,008...66,013,505
Ensembl chr11:66,012,008...66,013,505
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G |
CST7 |
cystatin F |
increases expression |
EXP |
Amiodarone results in increased expression of CST7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr20:24,949,269...24,959,928
Ensembl chr20:24,949,269...24,959,928
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G |
CTC1 |
CST telomere replication complex component 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CTC1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:8,224,815...8,248,056
Ensembl chr17:8,224,815...8,248,058
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G |
CTLA4 |
cytotoxic T-lymphocyte associated protein 4 |
increases expression |
EXP |
Amiodarone results in increased expression of CTLA4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
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G |
CTNNA1 |
catenin alpha 1 |
affects expression |
ISO |
Amiodarone affects the expression of CTNNA1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
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G |
CTNNB1 |
catenin beta 1 |
multiple interactions |
EXP |
ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein]; Amiodarone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of BCL2 protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of BAX protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 mRNA]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of CASP3 protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 protein]]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of TNF protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of and results in decreased phosphorylation of CTNNB1 protein]] |
CTD |
PMID:34434487 |
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NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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G |
CTSB |
cathepsin B |
affects cleavage |
EXP |
Amiodarone affects the cleavage of CTSB protein |
CTD |
PMID:25881747 |
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NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
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G |
CTSD |
cathepsin D |
affects cleavage |
EXP |
Amiodarone affects the cleavage of CTSD protein |
CTD |
PMID:25881747 |
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NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
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G |
CTSL |
cathepsin L |
affects cleavage |
EXP |
Amiodarone affects the cleavage of CTSL protein |
CTD |
PMID:25881747 |
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NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469
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G |
CXCL2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Amiodarone inhibits the reaction [Dexamethasone results in increased expression of CXCL2 mRNA] |
CTD |
PMID:25900201 |
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NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA; [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of CXCL8 protein; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA] |
CTD |
PMID:22785256 |
|
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
increases expression decreases activity increases response to substance multiple interactions |
ISO EXP |
Amiodarone results in increased expression of CYP1A1 mRNA Amiodarone results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased susceptibility to Amiodarone Amiodarone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:19224547 PMID:20362646 PMID:26477383 PMID:32084307 PMID:33814510 PMID:34181028 More...
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
decreases activity multiple interactions decreases response to substance |
EXP |
Amiodarone results in decreased activity of CYP1A2 protein [Amiodarone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin CYP1A2 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:16449812 PMID:26477383 PMID:26599973 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP1B1 |
cytochrome P450 family 1 subfamily B member 1 |
decreases response to substance decreases activity |
EXP |
CYP1B1 protein results in decreased susceptibility to Amiodarone Amiodarone results in decreased activity of CYP1B1 protein |
CTD |
PMID:26477383 PMID:33814510 |
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NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
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G |
CYP26A1 |
cytochrome P450 family 26 subfamily A member 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CYP26A1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
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G |
CYP2A13 |
cytochrome P450 family 2 subfamily A member 13 |
affects expression increases expression |
ISO |
Amiodarone affects the expression of CYP2A1 mRNA Amiodarone results in increased expression of CYP2A1 mRNA |
CTD |
PMID:18355885 PMID:19483382 PMID:32084307 |
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NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195
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G |
CYP2A6 |
cytochrome P450 family 2 subfamily A member 6 |
decreases response to substance |
EXP |
CYP2A6 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:26477383 |
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NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
affects expression decreases response to substance increases expression |
ISO EXP |
Amiodarone affects the expression of CYP2B3 mRNA CYP2B6 protein results in decreased susceptibility to Amiodarone Amiodarone results in increased expression of CYP2B10 mRNA |
CTD |
PMID:19483382 PMID:24535564 PMID:26477383 |
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NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP2C18 |
cytochrome P450 family 2 subfamily C member 18 |
decreases response to substance decreases expression |
EXP ISO |
CYP2C18 protein results in decreased susceptibility to Amiodarone Amiodarone results in decreased expression of CYP2C11 mRNA |
CTD |
PMID:26477383 PMID:32084307 |
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NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
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G |
CYP2C19 |
cytochrome P450 family 2 subfamily C member 19 |
decreases response to substance |
EXP |
CYP2C19 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:26477383 |
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NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
decreases activity decreases response to substance multiple interactions increases metabolic processing |
EXP |
Amiodarone results in decreased activity of CYP2C8 protein CYP2C8 protein results in decreased susceptibility to Amiodarone torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein] CYP2C8 protein results in increased metabolism of Amiodarone |
CTD |
PMID:15304522 PMID:15716363 PMID:26477383 |
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NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
multiple interactions increases expression decreases response to substance decreases activity |
EXP |
[Amiodarone results in decreased activity of CYP2C9 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Amiodarone results in decreased activity of CYP2C9 protein] which results in decreased chemical synthesis of Aconitine metabolite; Amiodarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Amiodarone promotes the reaction [CYP2C9 protein affects the metabolism of Naproxen]; Amiodarone promotes the reaction [CYP2C9 protein results in increased metabolism of Coumarins] Amiodarone results in increased expression of CYP2C9 mRNA CYP2C9 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:14557374 PMID:16081671 PMID:16449812 PMID:21277363 PMID:26477383 PMID:36586010 More...
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NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) |
decreases activity affects expression multiple interactions increases expression |
EXP ISO |
Amiodarone results in decreased activity of CYP2D6 protein Amiodarone affects the expression of CYP2D4 mRNA CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol] Amiodarone results in increased expression of CYP2D6 mRNA |
CTD |
PMID:15541258 PMID:16449812 PMID:19483382 PMID:19774075 |
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NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
decreases response to substance |
EXP |
CYP2E1 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:26477383 |
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NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP2F1 |
cytochrome P450 family 2 subfamily F member 1 |
affects expression |
ISO |
Amiodarone affects the expression of CYP2F4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:41,114,432...41,128,381
Ensembl chr19:41,114,432...41,128,381
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G |
CYP2J2 |
cytochrome P450 family 2 subfamily J member 2 |
increases expression affects expression |
EXP ISO |
Amiodarone results in increased expression of CYP2J2 mRNA Amiodarone affects the expression of CYP2J4 mRNA |
CTD |
PMID:19483382 PMID:19774075 |
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NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773
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G |
CYP2R1 |
cytochrome P450 family 2 subfamily R member 1 |
increases expression |
EXP |
Amiodarone results in increased expression of CYP2R1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:14,877,440...14,892,443
Ensembl chr11:14,877,440...14,892,231
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G |
CYP2U1 |
cytochrome P450 family 2 subfamily U member 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of CYP2U1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 4:107,931,549...107,953,461
Ensembl chr 4:107,931,549...107,953,461
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G |
CYP39A1 |
cytochrome P450 family 39 subfamily A member 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of CYP39A1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
decreases ethylation increases degradation increases expression increases response to substance increases metabolic processing decreases activity multiple interactions |
EXP ISO |
CYP3A4 protein results in decreased ethylation of Amiodarone CYP3A4 protein results in increased degradation of Amiodarone Amiodarone results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased susceptibility to Amiodarone CYP3A4 protein results in increased metabolism of Amiodarone Amiodarone results in decreased activity of CYP3A4 protein [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of CD86 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA; [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of CXCL8 protein; [Amiodarone co-treated with CYP3A4 protein] results in increased secretion of TNF protein; [CYP3A4 protein results in increased metabolism of Amiodarone] which results in increased abundance of mono-N-desethylamiodarone; Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Amiodarone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] |
CTD |
PMID:7905403 PMID:8445979 PMID:15304522 PMID:15869686 PMID:16449812 PMID:19224547 PMID:19299527 PMID:21540358 PMID:22652334 PMID:22785256 PMID:26477383 PMID:27485346 PMID:32305697 PMID:34273450 More...
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
CYP3A5 |
cytochrome P450 family 3 subfamily A member 5 |
affects expression decreases response to substance |
ISO EXP |
Amiodarone affects the expression of CYP3A9 mRNA CYP3A5 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:19483382 PMID:26477383 |
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NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996
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G |
CYP3A7 |
cytochrome P450 family 3 subfamily A member 7 |
decreases response to substance |
EXP |
CYP3A7 protein results in decreased susceptibility to Amiodarone |
CTD |
PMID:26477383 |
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NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
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G |
CYP4A22 |
cytochrome P450 family 4 subfamily A member 22 |
increases expression |
ISO |
Amiodarone results in increased expression of CYP4A1 mRNA Amiodarone results in increased expression of CYP4A31 mRNA |
CTD |
PMID:12883083 PMID:24535564 |
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NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727
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G |
CYP4F8 |
cytochrome P450 family 4 subfamily F member 8 |
affects expression |
ISO |
Amiodarone affects the expression of CYP4F6 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:15,615,218...15,630,639
Ensembl chr19:15,615,218...15,630,639
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G |
CYP7A1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression increases expression |
ISO |
Amiodarone results in decreased expression of CYP7A1 mRNA Amiodarone results in increased expression of CYP7A1 mRNA |
CTD |
PMID:19224547 PMID:22291062 |
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NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
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G |
CYP7B1 |
cytochrome P450 family 7 subfamily B member 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of CYP7B1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737
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G |
DACT1 |
dishevelled binding antagonist of beta catenin 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of DACT1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr14:58,634,061...58,648,321
Ensembl chr14:58,633,967...58,648,321
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G |
DAPK2 |
death associated protein kinase 2 |
increases expression |
EXP |
Amiodarone results in increased expression of DAPK2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:63,907,036...64,046,485
Ensembl chr15:63,907,036...64,072,033
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G |
DBI |
diazepam binding inhibitor, acyl-CoA binding protein |
affects expression |
ISO |
Amiodarone affects the expression of DBI mRNA |
CTD |
PMID:19483382 |
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NCBI chr 2:119,366,977...119,372,543
Ensembl chr 2:119,366,924...119,372,550
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G |
DBN1 |
drebrin 1 |
increases expression |
EXP |
Amiodarone results in increased expression of DBN1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:177,456,610...177,473,634
Ensembl chr 5:177,456,608...177,474,401
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G |
DBNDD1 |
dysbindin domain containing 1 |
increases expression |
EXP |
Amiodarone results in increased expression of DBNDD1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:90,004,871...90,019,890
Ensembl chr16:90,004,871...90,019,890
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DCAF11 |
DDB1 and CUL4 associated factor 11 |
affects expression |
ISO |
Amiodarone affects the expression of DCAF11 mRNA |
CTD |
PMID:19483382 |
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NCBI chr14:24,114,777...24,125,242
Ensembl chr14:24,114,195...24,125,242
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DCAF8 |
DDB1 and CUL4 associated factor 8 |
affects expression |
ISO |
Amiodarone affects the expression of DCAF8 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:160,215,720...160,262,549
Ensembl chr 1:160,215,715...160,262,549
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DCST2 |
DC-STAMP domain containing 2 |
increases expression |
EXP |
Amiodarone results in increased expression of DCST2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:155,018,527...155,033,781
Ensembl chr 1:155,018,520...155,033,781
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DCTN1 |
dynactin subunit 1 |
increases expression |
EXP |
Amiodarone results in increased expression of DCTN1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:74,361,155...74,391,866
Ensembl chr 2:74,361,154...74,392,087
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DCXR |
dicarbonyl and L-xylulose reductase |
affects expression |
ISO |
Amiodarone affects the expression of DCXR mRNA |
CTD |
PMID:19483382 |
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NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
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DDC |
dopa decarboxylase |
increases expression |
ISO |
Amiodarone results in increased expression of DDC mRNA |
CTD |
PMID:24489787 |
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NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405
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DDIT3 |
DNA damage inducible transcript 3 |
increases expression decreases response to substance multiple interactions |
EXP ISO |
[Amiodarone results in increased expression of DDIT3 mRNA] which results in increased expression of TNFRSF10B mRNA; [Amiodarone results in increased expression of DDIT3 protein] which results in increased expression of TNFRSF10B protein; Amiodarone results in increased expression of DDIT3 mRNA; Amiodarone results in increased expression of DDIT3 protein DDIT3 gene mutant form results in decreased susceptibility to Amiodarone 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of DDIT3 mRNA]; Amiodarone results in increased expression of and affects the localization of DDIT3 protein; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEA mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEC protein]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased splicing of XBP1 mRNA] 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DDIT3 protein]; DDIT3 mutant form inhibits the reaction [Amiodarone results in increased expression of TNFRSF10B]; Egtazic Acid inhibits the reaction [Amiodarone results in increased expression of DDIT3] |
CTD |
PMID:19774075 PMID:21292685 PMID:25295624 PMID:28962527 PMID:32651653 PMID:34259586 PMID:36586010 More...
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NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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DDIT4 |
DNA damage inducible transcript 4 |
increases expression |
EXP |
Amiodarone results in increased expression of DDIT4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036
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DDX17 |
DEAD-box helicase 17 |
increases expression |
EXP |
Amiodarone results in increased expression of DDX17 mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:38,483,438...38,506,311
Ensembl chr22:38,483,438...38,507,660
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DDX31 |
DEAD-box helicase 31 |
increases expression |
EXP |
Amiodarone results in increased expression of DDX31 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:132,592,997...132,669,983
Ensembl chr 9:132,592,997...132,670,401
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DDX39A |
DExD-box helicase 39A |
increases expression |
EXP |
Amiodarone results in increased expression of DDX39A mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:14,408,798...14,419,383
Ensembl chr19:14,408,798...14,419,383
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DDX49 |
DEAD-box helicase 49 |
increases expression |
EXP |
Amiodarone results in increased expression of DDX49 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:18,919,715...18,928,630
Ensembl chr19:18,919,705...18,929,189
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DECR1 |
2,4-dienoyl-CoA reductase 1 |
affects expression |
ISO |
Amiodarone affects the expression of DECR1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 8:90,001,477...90,053,633
Ensembl chr 8:90,001,405...90,053,633
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DEDD |
death effector domain containing |
increases expression |
EXP |
Amiodarone results in increased expression of DEDD mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:161,120,974...161,132,667
Ensembl chr 1:161,120,974...161,132,688
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DEPP1 |
DEPP autophagy regulator 1 |
increases expression |
EXP |
Amiodarone results in increased expression of DEPP1 mRNA |
CTD |
PMID:17175557 |
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NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809
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DEPTOR |
DEP domain containing MTOR interacting protein |
increases expression |
EXP |
Amiodarone results in increased expression of DEPTOR mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:119,873,722...120,050,918
Ensembl chr 8:119,873,717...120,050,918
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DEXI |
Dexi homolog |
affects expression |
ISO |
Amiodarone affects the expression of DEXI mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:10,928,891...10,942,468
Ensembl chr16:10,928,891...10,942,468
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DGAT1 |
diacylglycerol O-acyltransferase 1 |
affects expression increases expression |
ISO EXP |
Amiodarone affects the expression of DGAT1 mRNA Amiodarone results in increased expression of DGAT1 mRNA |
CTD |
PMID:19483382 PMID:32651653 |
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NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
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DGAT2 |
diacylglycerol O-acyltransferase 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of DGAT2 mRNA |
CTD |
PMID:28962527 |
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NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
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DHCR24 |
24-dehydrocholesterol reductase |
affects expression |
ISO |
Amiodarone affects the expression of DHCR24 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195
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DHCR7 |
7-dehydrocholesterol reductase |
increases expression |
ISO |
Amiodarone results in increased expression of DHCR7 mRNA |
CTD |
PMID:22291062 |
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NCBI chr11:71,427,287...71,449,043
Ensembl chr11:71,428,193...71,452,868
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DHRS2 |
dehydrogenase/reductase 2 |
increases expression |
EXP |
Amiodarone results in increased expression of DHRS2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr14:23,630,115...23,645,639
Ensembl chr14:23,630,115...23,645,639
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DHRS4 |
dehydrogenase/reductase 4 |
affects expression |
ISO |
Amiodarone affects the expression of DHRS4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr14:23,953,770...23,969,279
Ensembl chr14:23,953,734...23,969,279
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DHRS7B |
dehydrogenase/reductase 7B |
affects expression |
ISO |
Amiodarone affects the expression of DHRS7B mRNA |
CTD |
PMID:19483382 |
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NCBI chr17:21,126,964...21,191,420
Ensembl chr17:21,123,364...21,193,265
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DHX16 |
DEAH-box helicase 16 |
affects expression |
ISO |
Amiodarone affects the expression of DHX16 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 6:30,653,127...30,673,006
Ensembl chr 6:30,653,119...30,673,006
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DHX57 |
DExH-box helicase 57 |
increases expression |
EXP |
Amiodarone results in increased expression of DHX57 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:38,797,729...38,875,934
Ensembl chr 2:38,797,729...38,875,934
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DIO1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO EXP |
Amiodarone results in decreased activity of DIO1 protein |
CTD |
PMID:12538616 PMID:16131326 |
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NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
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DLG4 |
discs large MAGUK scaffold protein 4 |
increases expression |
EXP |
Amiodarone results in increased expression of DLG4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836
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DLK2 |
delta like non-canonical Notch ligand 2 |
increases expression |
EXP |
Amiodarone results in increased expression of DLK2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:43,450,352...43,456,632
Ensembl chr 6:43,450,352...43,456,632
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DMAC2L |
distal membrane arm assembly component 2 like |
affects expression |
ISO |
Amiodarone affects the expression of DMAC2L mRNA |
CTD |
PMID:19483382 |
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NCBI chr14:50,311,516...50,327,957
Ensembl chr14:50,312,324...50,335,558
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DNAAF3 |
dynein axonemal assembly factor 3 |
increases expression |
EXP |
Amiodarone results in increased expression of DNAAF3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:55,158,661...55,166,722
Ensembl chr19:55,158,661...55,166,722
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DNAH7 |
dynein axonemal heavy chain 7 |
increases expression |
EXP |
Amiodarone results in increased expression of DNAH7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:195,737,703...196,068,837
Ensembl chr 2:195,737,703...196,068,837
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DNAJB11 |
DnaJ heat shock protein family (Hsp40) member B11 |
decreases expression |
ISO |
Amiodarone results in decreased expression of DNAJB11 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 3:186,570,720...186,585,793
Ensembl chr 3:186,567,403...186,585,800
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DNAJB12 |
DnaJ heat shock protein family (Hsp40) member B12 |
increases expression |
EXP |
Amiodarone results in increased expression of DNAJB12 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:72,332,863...72,354,919
Ensembl chr10:72,332,830...72,355,149
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DNAJB7 |
DnaJ heat shock protein family (Hsp40) member B7 |
increases expression |
EXP |
Amiodarone results in increased expression of DNAJB7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:40,859,549...40,862,113
Ensembl chr22:40,859,549...40,862,113
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DNAJB9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression multiple interactions |
EXP ISO |
Amiodarone results in increased expression of DNAJB9 mRNA Amiodarone results in increased expression of DNAJB9 mRNA; Amiodarone results in increased expression of DNAJB9 protein 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA] |
CTD |
PMID:19774075 PMID:28962527 PMID:34259586 PMID:36586010 |
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NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
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DNAJC3 |
DnaJ heat shock protein family (Hsp40) member C3 |
affects expression multiple interactions increases expression |
ISO |
Amiodarone affects the expression of DNAJC3 mRNA 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of DNAJC3 mRNA] |
CTD |
PMID:19483382 PMID:28962527 PMID:34259586 |
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NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988
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DNASE1 |
deoxyribonuclease 1 |
increases expression |
EXP |
Amiodarone results in increased expression of DNASE1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:3,611,760...3,665,461
Ensembl chr16:3,611,728...3,680,143
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DOCK5 |
dedicator of cytokinesis 5 |
increases expression |
EXP |
Amiodarone results in increased expression of DOCK5 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:25,184,689...25,415,711
Ensembl chr 8:25,184,689...25,418,082
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DPM2 |
dolichyl-phosphate mannosyltransferase subunit 2, regulatory |
increases expression |
EXP |
Amiodarone results in increased expression of DPM2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:127,935,099...127,937,854
Ensembl chr 9:127,935,099...127,937,854
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DPP4 |
dipeptidyl peptidase 4 |
affects expression |
ISO |
Amiodarone affects the expression of DPP4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394
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DPYD |
dihydropyrimidine dehydrogenase |
affects expression |
ISO |
Amiodarone affects the expression of DPYD mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
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DRC7 |
dynein regulatory complex subunit 7 |
increases expression |
EXP |
Amiodarone results in increased expression of DRC7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:57,694,806...57,731,805
Ensembl chr16:57,694,793...57,731,805
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DUSP1 |
dual specificity phosphatase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of DUSP1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
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DUSP10 |
dual specificity phosphatase 10 |
increases expression |
EXP |
Amiodarone results in increased expression of DUSP10 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:221,701,424...221,742,089
Ensembl chr 1:221,701,424...221,742,089
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DUT |
deoxyuridine triphosphatase |
increases expression |
EXP |
Amiodarone results in increased expression of DUT mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373
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EAF2 |
ELL associated factor 2 |
increases expression |
EXP |
Amiodarone results in increased expression of EAF2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:121,835,209...121,886,526
Ensembl chr 3:121,835,183...121,886,526
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EARS2 |
glutamyl-tRNA synthetase 2, mitochondrial |
affects expression |
ISO |
Amiodarone affects the expression of EARS2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:23,520,754...23,557,375
Ensembl chr16:23,520,754...23,557,731
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EBP |
EBP cholestenol delta-isomerase |
increases expression |
ISO |
Amiodarone results in increased expression of EBP mRNA |
CTD |
PMID:22291062 |
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NCBI chr X:48,521,808...48,528,716
Ensembl chr X:48,521,799...48,528,716
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ECH1 |
enoyl-CoA hydratase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of ECH1 mRNA |
CTD |
PMID:24535564 |
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NCBI chr19:38,815,422...38,831,794
Ensembl chr19:38,815,422...38,831,841
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ECHS1 |
enoyl-CoA hydratase, short chain 1 |
affects expression |
ISO |
Amiodarone affects the expression of ECHS1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354
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ECI1 |
enoyl-CoA delta isomerase 1 |
affects expression |
ISO |
Amiodarone affects the expression of ECI1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:2,239,402...2,251,587
Ensembl chr16:2,239,402...2,252,300
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ECI2 |
enoyl-CoA delta isomerase 2 |
affects expression |
ISO |
Amiodarone affects the expression of ECI2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 6:4,115,706...4,135,575
Ensembl chr 6:4,115,693...4,135,597
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ECPAS |
Ecm29 proteasome adaptor and scaffold |
decreases expression |
ISO |
Amiodarone results in decreased expression of ECPAS mRNA |
CTD |
PMID:17991464 |
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NCBI chr 9:111,360,685...111,484,383
Ensembl chr 9:111,360,685...111,484,745
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EED |
embryonic ectoderm development |
increases expression |
EXP |
Amiodarone results in increased expression of EED mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:86,244,753...86,287,615
Ensembl chr11:86,201,212...86,279,807
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EEF1G |
eukaryotic translation elongation factor 1 gamma |
affects expression |
ISO |
Amiodarone affects the expression of EEF1G mRNA |
CTD |
PMID:19483382 |
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NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086
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EEPD1 |
endonuclease/exonuclease/phosphatase family domain containing 1 |
increases expression |
EXP |
Amiodarone results in increased expression of EEPD1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 7:36,153,254...36,301,538
Ensembl chr 7:36,153,254...36,301,538
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EFCAB5 |
EF-hand calcium binding domain 5 |
increases expression |
EXP |
Amiodarone results in increased expression of EFCAB5 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:29,929,903...30,108,452
Ensembl chr17:29,929,200...30,108,452
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EFCC1 |
EF-hand and coiled-coil domain containing 1 |
increases expression |
EXP |
Amiodarone results in increased expression of EFCC1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:129,001,304...129,040,742
Ensembl chr 3:129,001,304...129,040,742
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EGF |
epidermal growth factor |
multiple interactions |
EXP |
Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]] |
CTD |
PMID:26515726 |
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NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
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EGFL6 |
EGF like domain multiple 6 |
increases expression |
EXP |
Amiodarone results in increased expression of EGFL6 mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:13,569,601...13,633,575
Ensembl chr X:13,569,601...13,633,575
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EGFR |
epidermal growth factor receptor |
decreases expression multiple interactions decreases phosphorylation |
ISO EXP |
Amiodarone results in decreased expression of EGFR mRNA Amiodarone affects the reaction [VCAN protein alternative form affects the phosphorylation of EGFR protein] Amiodarone results in decreased phosphorylation of EGFR protein Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]] |
CTD |
PMID:24535564 PMID:26515726 |
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NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
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EGR1 |
early growth response 1 |
increases expression |
EXP |
Amiodarone results in increased expression of EGR1 mRNA |
CTD |
PMID:19774075 PMID:36586010 |
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NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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EGR2 |
early growth response 2 |
increases expression |
EXP |
Amiodarone results in increased expression of EGR2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167
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EHHADH |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
affects expression decreases expression increases expression |
ISO EXP |
Amiodarone affects the expression of EHHADH mRNA Amiodarone results in decreased expression of EHHADH mRNA Amiodarone results in increased expression of EHHADH mRNA |
CTD |
PMID:15265979 PMID:19483382 PMID:24489787 PMID:24535564 PMID:27089845 |
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NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990
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G |
EHMT1 |
euchromatic histone lysine methyltransferase 1 |
increases expression |
EXP |
Amiodarone results in increased expression of EHMT1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:137,619,005...137,836,127
Ensembl chr 9:137,618,992...137,870,016
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G |
EIF2A |
eukaryotic translation initiation factor 2A |
increases phosphorylation |
EXP ISO |
Amiodarone results in increased phosphorylation of EIF2A protein |
CTD |
PMID:21292685 PMID:28962527 |
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NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
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G |
EIF2AK3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases expression |
EXP |
Amiodarone results in increased expression of EIF2AK3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
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EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
EXP ISO |
Amiodarone results in increased phosphorylation of EIF2S1 protein 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:25295624 PMID:32651653 PMID:34259586 |
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NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
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G |
EIF4A2 |
eukaryotic translation initiation factor 4A2 |
affects expression |
ISO |
Amiodarone affects the expression of EIF4A2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897
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EIF4B |
eukaryotic translation initiation factor 4B |
affects expression |
ISO |
Amiodarone affects the expression of EIF4B mRNA |
CTD |
PMID:18355885 |
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NCBI chr12:53,006,456...53,042,215
Ensembl chr12:53,006,282...53,042,215
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EIF4E |
eukaryotic translation initiation factor 4E |
multiple interactions |
EXP |
Amiodarone promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:19771169 |
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NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,879,276...98,929,133
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G |
EIF4EBP1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases phosphorylation affects expression |
EXP ISO |
Amiodarone inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Amiodarone promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] Amiodarone results in decreased phosphorylation of EIF4EBP1 protein Amiodarone affects the expression of EIF4EBP1 mRNA |
CTD |
PMID:19483382 PMID:19771169 PMID:23912912 |
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NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
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G |
EIF4H |
eukaryotic translation initiation factor 4H |
affects expression |
ISO |
Amiodarone affects the expression of EIF4H mRNA |
CTD |
PMID:19483382 |
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NCBI chr 7:74,174,356...74,197,096
Ensembl chr 7:74,174,231...74,197,122
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G |
EIF5 |
eukaryotic translation initiation factor 5 |
increases expression |
EXP |
Amiodarone results in increased expression of EIF5 mRNA |
CTD |
PMID:19774075 |
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NCBI chr14:103,334,237...103,345,025
Ensembl chr14:103,333,544...103,345,025
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ELMO3 |
engulfment and cell motility 3 |
increases expression |
EXP |
Amiodarone results in increased expression of ELMO3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:67,199,131...67,204,004
Ensembl chr16:67,199,111...67,204,029
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ELOVL6 |
ELOVL fatty acid elongase 6 |
increases expression decreases expression |
ISO EXP |
Amiodarone results in increased expression of ELOVL6 mRNA Amiodarone results in decreased expression of ELOVL6 mRNA; Amiodarone results in decreased expression of ELOVL6 protein |
CTD |
PMID:24489787 PMID:29248575 PMID:34259586 |
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NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199
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ELP1 |
elongator acetyltransferase complex subunit 1 |
increases expression |
EXP |
Amiodarone results in increased expression of ELP1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:108,867,517...108,934,124
Ensembl chr 9:108,866,898...108,934,328
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G |
ENC1 |
ectodermal-neural cortex 1 |
affects expression |
ISO |
Amiodarone affects the expression of ENC1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424
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ENHO |
energy homeostasis associated |
decreases expression |
ISO |
Amiodarone results in decreased expression of ENHO mRNA |
CTD |
PMID:24535564 |
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NCBI chr 9:34,521,043...34,522,990
Ensembl chr 9:34,521,043...34,522,990
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G |
ENO1 |
enolase 1 |
affects expression |
ISO |
Amiodarone affects the expression of ENO1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
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G |
ENPEP |
glutamyl aminopeptidase |
affects expression |
ISO |
Amiodarone affects the expression of ENPEP mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285
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G |
ENPP1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
affects expression |
ISO |
Amiodarone affects the expression of ENPP1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155
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G |
ENPP7 |
ectonucleotide pyrophosphatase/phosphodiesterase 7 |
increases expression |
EXP |
Amiodarone results in increased expression of ENPP7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,730,943...79,742,219
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G |
EPC1 |
enhancer of polycomb homolog 1 |
increases expression |
EXP |
Amiodarone results in increased expression of EPC1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:32,267,751...32,378,769
Ensembl chr10:32,267,751...32,378,798
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G |
EPC2 |
enhancer of polycomb homolog 2 |
increases expression |
EXP |
Amiodarone results in increased expression of EPC2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:148,644,751...148,787,569
Ensembl chr 2:148,644,440...148,788,495
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G |
EPCAM |
epithelial cell adhesion molecule |
affects expression |
ISO |
Amiodarone affects the expression of EPCAM mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601
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G |
EPHX1 |
epoxide hydrolase 1 |
affects expression |
ISO |
Amiodarone affects the expression of EPHX1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
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G |
ERI2 |
ERI1 exoribonuclease family member 2 |
increases expression |
EXP |
Amiodarone results in increased expression of ERI2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr16:20,780,193...20,806,472
Ensembl chr16:20,780,193...20,900,349
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ERMN |
ermin |
increases expression |
EXP |
Amiodarone results in increased expression of ERMN mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:157,318,631...157,327,712
Ensembl chr 2:157,318,631...157,327,713
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G |
ERN1 |
endoplasmic reticulum to nucleus signaling 1 |
increases phosphorylation |
ISO EXP |
Amiodarone results in increased phosphorylation of ERN1 protein |
CTD |
PMID:28962527 PMID:32651653 PMID:34259586 |
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NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819
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G |
ERO1B |
endoplasmic reticulum oxidoreductase 1 beta |
decreases expression |
ISO |
Amiodarone results in decreased expression of ERO1B mRNA |
CTD |
PMID:24535564 |
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NCBI chr 1:236,215,101...236,281,958
Ensembl chr 1:236,214,681...236,282,019
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G |
ERP29 |
endoplasmic reticulum protein 29 |
affects expression |
ISO |
Amiodarone affects the expression of ERP29 mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr12:112,013,426...112,023,449
Ensembl chr12:112,013,348...112,023,449
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G |
ESD |
esterase D |
affects expression |
ISO |
Amiodarone affects the expression of ESD mRNA |
CTD |
PMID:19483382 |
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NCBI chr13:46,771,256...46,797,700
Ensembl chr13:46,771,256...46,797,420
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G |
ETFB |
electron transfer flavoprotein subunit beta |
affects expression |
ISO |
Amiodarone affects the expression of ETFB mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:51,345,155...51,366,388
Ensembl chr19:51,345,169...51,366,388
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G |
ETFDH |
electron transfer flavoprotein dehydrogenase |
increases expression |
ISO |
Amiodarone results in increased expression of ETFDH mRNA |
CTD |
PMID:24489787 |
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NCBI chr 4:158,672,296...158,709,623
Ensembl chr 4:158,671,968...158,710,742
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G |
ETV7 |
ETS variant transcription factor 7 |
increases expression |
EXP |
Amiodarone results in increased expression of ETV7 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:36,354,088...36,387,669
Ensembl chr 6:36,354,091...36,387,800
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G |
EXO1 |
exonuclease 1 |
increases expression |
EXP |
Amiodarone results in increased expression of EXO1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148
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G |
F11 |
coagulation factor XI |
decreases expression |
ISO |
Amiodarone results in decreased expression of F11 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 4:186,266,189...186,289,681
Ensembl chr 4:186,266,189...186,289,681
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
EXP |
Amiodarone inhibits the reaction [F2 protein results in increased expression of and results in increased activity of F3 protein] |
CTD |
PMID:18974383 |
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NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions decreases activity |
EXP ISO |
Amiodarone inhibits the reaction [F2 protein results in increased expression of and results in increased activity of F3 protein]; Amiodarone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of F3 protein]; Amiodarone inhibits the reaction [TNF protein results in increased expression of F3 mRNA]; Amiodarone inhibits the reaction [TNF protein results in increased expression of F3 protein] Amiodarone results in decreased activity of F3 protein |
CTD |
PMID:18974383 PMID:23305835 |
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NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
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G |
FAAH |
fatty acid amide hydrolase |
affects expression |
ISO |
Amiodarone affects the expression of FAAH mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848
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G |
FABP1 |
fatty acid binding protein 1 |
increases expression decreases expression |
EXP ISO |
Amiodarone results in increased expression of FABP1 mRNA Amiodarone results in decreased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17567588 PMID:28962527 |
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NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
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G |
FABP4 |
fatty acid binding protein 4 |
increases expression |
ISO |
Amiodarone results in increased expression of FABP4 mRNA |
CTD |
PMID:34259586 |
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NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
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G |
FADS1 |
fatty acid desaturase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of FADS1 mRNA |
CTD |
PMID:19224547 PMID:22291062 |
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NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
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G |
FADS2 |
fatty acid desaturase 2 |
multiple interactions affects expression increases expression |
EXP ISO |
[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of FADS2 mRNA]; FADS2 protein affects the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine] Amiodarone affects the expression of FADS2 mRNA |
CTD |
PMID:19483382 PMID:21123845 PMID:29248575 |
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NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
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FAM153A |
family with sequence similarity 153 member A |
increases expression |
EXP |
Amiodarone results in increased expression of FAM153A mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:177,694,247...177,783,425
Ensembl chr 5:177,707,981...177,784,435
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G |
FAM81A |
family with sequence similarity 81 member A |
increases expression |
EXP |
Amiodarone results in increased expression of FAM81A mRNA |
CTD |
PMID:19774075 |
|
NCBI chr15:59,397,981...59,523,555
Ensembl chr15:59,372,693...59,523,555
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G |
FAM89A |
family with sequence similarity 89 member A |
increases expression |
EXP |
Amiodarone results in increased expression of FAM89A mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:231,018,958...231,040,254
Ensembl chr 1:231,018,958...231,040,254
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FANCA |
FA complementation group A |
increases expression |
EXP |
Amiodarone results in increased expression of FANCA mRNA |
CTD |
PMID:19774075 |
|
NCBI chr16:89,737,549...89,816,647
Ensembl chr16:89,726,683...89,816,977
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G |
FARP2 |
FERM, ARH/RhoGEF and pleckstrin domain protein 2 |
increases expression |
EXP |
Amiodarone results in increased expression of FARP2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:241,356,285...241,494,841
Ensembl chr 2:241,356,285...241,494,841
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G |
FASN |
fatty acid synthase |
increases expression decreases expression affects expression |
ISO EXP |
Amiodarone results in increased expression of FASN mRNA Amiodarone results in decreased expression of FASN mRNA; Amiodarone results in decreased expression of FASN protein Amiodarone affects the expression of FASN mRNA |
CTD |
PMID:22291062 PMID:24489787 PMID:29248575 PMID:32084307 PMID:34259586 |
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NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
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G |
FBP1 |
fructose-bisphosphatase 1 |
affects expression |
ISO |
Amiodarone affects the expression of FBP1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249
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G |
FBXO16 |
F-box protein 16 |
increases expression |
EXP |
Amiodarone results in increased expression of FBXO16 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 8:28,428,412...28,490,229
Ensembl chr 8:28,348,287...28,490,278
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G |
FBXO32 |
F-box protein 32 |
increases expression |
EXP |
Amiodarone results in increased expression of FBXO32 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
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G |
FCGR2B |
Fc gamma receptor IIb |
increases expression |
ISO |
Amiodarone results in increased expression of FCGR2B mRNA |
CTD |
PMID:25580480 |
|
NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654
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G |
FCRL1 |
Fc receptor like 1 |
increases expression |
EXP |
Amiodarone results in increased expression of FCRL1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:157,794,403...157,820,120
Ensembl chr 1:157,792,249...157,820,120
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G |
FCRL2 |
Fc receptor like 2 |
increases expression |
EXP |
Amiodarone results in increased expression of FCRL2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:157,745,733...157,777,132
Ensembl chr 1:157,745,733...157,777,132
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G |
FCRL3 |
Fc receptor like 3 |
increases expression |
EXP |
Amiodarone results in increased expression of FCRL3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:157,676,481...157,700,956
Ensembl chr 1:157,674,321...157,700,769
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G |
FDFT1 |
farnesyl-diphosphate farnesyltransferase 1 |
affects expression increases expression |
ISO |
Amiodarone affects the expression of FDFT1 mRNA Amiodarone results in increased expression of FDFT1 mRNA |
CTD |
PMID:19483382 PMID:22291062 |
|
NCBI chr 8:11,795,582...11,839,298
Ensembl chr 8:11,795,573...11,839,395
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G |
FDPS |
farnesyl diphosphate synthase |
affects expression increases expression |
ISO |
Amiodarone affects the expression of FDPS mRNA Amiodarone results in increased expression of FDPS mRNA |
CTD |
PMID:19483382 PMID:22291062 |
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NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666
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G |
FDX2 |
ferredoxin 2 |
affects expression |
ISO |
Amiodarone affects the expression of FDX2 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr19:10,310,045...10,316,015
Ensembl chr19:10,309,916...10,316,015
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G |
FFAR3 |
free fatty acid receptor 3 |
increases expression |
EXP |
Amiodarone results in increased expression of FFAR3 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr19:35,358,151...35,360,489
Ensembl chr19:35,358,460...35,360,489
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G |
FGD4 |
FYVE, RhoGEF and PH domain containing 4 |
increases expression |
EXP |
Amiodarone results in increased expression of FGD4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:32,399,558...32,646,050
Ensembl chr12:32,399,558...32,646,050
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G |
FGD5 |
FYVE, RhoGEF and PH domain containing 5 |
increases expression |
EXP |
Amiodarone results in increased expression of FGD5 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 3:14,810,688...14,934,571
Ensembl chr 3:14,810,853...14,934,571
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G |
FGF21 |
fibroblast growth factor 21 |
increases expression |
ISO |
Amiodarone results in increased expression of FGF21 mRNA |
CTD |
PMID:24489787 |
|
NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333
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G |
FGF7 |
fibroblast growth factor 7 |
increases expression |
ISO |
Amiodarone results in increased expression of FGF7 protein |
CTD |
PMID:32909452 |
|
NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775
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G |
FGFR1OP2 |
FGFR1 oncogene partner 2 |
increases expression |
EXP |
Amiodarone results in increased expression of FGFR1OP2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr12:26,938,470...26,966,648
Ensembl chr12:26,938,470...26,966,650
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G |
FIBCD1 |
fibrinogen C domain containing 1 |
increases expression |
EXP |
Amiodarone results in increased expression of FIBCD1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 9:130,902,440...130,940,709
Ensembl chr 9:130,902,438...130,939,286
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G |
FKBP10 |
FKBP prolyl isomerase 10 |
increases expression |
EXP |
Amiodarone results in increased expression of FKBP10 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr17:41,813,004...41,823,213
Ensembl chr17:41,812,680...41,823,213
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G |
FKBP11 |
FKBP prolyl isomerase 11 |
decreases expression |
ISO |
Amiodarone results in decreased expression of FKBP11 mRNA |
CTD |
PMID:24535564 |
|
NCBI chr12:48,921,963...48,939,034
Ensembl chr12:48,921,518...48,926,474
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FLCN |
folliculin |
increases expression |
EXP |
Amiodarone results in increased expression of FLCN mRNA |
CTD |
PMID:19774075 |
|
NCBI chr17:17,212,212...17,237,330
Ensembl chr17:17,212,212...17,237,188
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G |
FMO1 |
flavin containing dimethylaniline monoxygenase 1 |
affects expression |
ISO |
Amiodarone affects the expression of FMO1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 1:171,248,494...171,285,978
Ensembl chr 1:171,248,471...171,285,978
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G |
FNDC4 |
fibronectin type III domain containing 4 |
increases expression |
EXP |
Amiodarone results in increased expression of FNDC4 mRNA |
CTD |
PMID:17175557 PMID:17567588 |
|
NCBI chr 2:27,491,883...27,495,200
Ensembl chr 2:27,491,883...27,495,200
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Amiodarone results in increased expression of FOS mRNA [FOS protein co-treated with JUN protein] promotes the reaction [Amiodarone results in increased expression of AGT mRNA] |
CTD |
PMID:17214612 PMID:19774075 PMID:36586010 |
|
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190
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G |
FOSB |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Amiodarone results in increased expression of FOSB mRNA |
CTD |
PMID:19774075 |
|
NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
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G |
FOXA1 |
forkhead box A1 |
decreases expression |
EXP |
Amiodarone results in decreased expression of FOXA1 mRNA |
CTD |
PMID:27089845 |
|
NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
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G |
FOXA3 |
forkhead box A3 |
decreases expression |
ISO |
Amiodarone results in decreased expression of FOXA3 mRNA |
CTD |
PMID:17991464 PMID:24535564 |
|
NCBI chr19:45,864,326...45,873,797
Ensembl chr19:45,863,989...45,873,797
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G |
FOXP3 |
forkhead box P3 |
increases expression |
EXP |
Amiodarone results in increased expression of FOXP3 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800
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G |
FRAS1 |
Fraser extracellular matrix complex subunit 1 |
increases expression |
EXP |
Amiodarone results in increased expression of FRAS1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 4:78,057,323...78,544,269
Ensembl chr 4:78,057,323...78,544,269
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G |
FRMD3 |
FERM domain containing 3 |
increases expression |
EXP |
Amiodarone results in increased expression of FRMD3 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 9:83,242,992...83,585,794
Ensembl chr 9:83,242,990...83,538,546
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|
G |
FRMD5 |
FERM domain containing 5 |
increases expression |
EXP |
Amiodarone results in increased expression of FRMD5 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr15:43,870,764...44,199,473
Ensembl chr15:43,870,761...44,195,271
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G |
FTL |
ferritin light chain |
increases expression |
EXP |
Amiodarone results in increased expression of FTL mRNA |
CTD |
PMID:36586010 |
|
NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,967,896
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|
G |
FUNDC2 |
FUN14 domain containing 2 |
increases expression |
EXP |
Amiodarone results in increased expression of FUNDC2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr X:155,026,844...155,060,304
Ensembl chr X:155,025,980...155,060,304
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|
G |
FUT4 |
fucosyltransferase 4 |
decreases expression |
ISO |
Amiodarone results in decreased expression of FUT4 mRNA |
CTD |
PMID:17991464 |
|
NCBI chr11:94,543,921...94,549,895
Ensembl chr11:94,543,921...94,549,895
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|
G |
FUZ |
fuzzy planar cell polarity protein |
increases expression |
EXP |
Amiodarone results in increased expression of FUZ mRNA |
CTD |
PMID:19774075 |
|
NCBI chr19:49,806,866...49,813,553
Ensembl chr19:49,806,866...49,817,376
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G |
FXYD1 |
FXYD domain containing ion transport regulator 1 |
increases expression |
EXP |
Amiodarone results in increased expression of FXYD1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr19:35,137,188...35,143,109
Ensembl chr19:35,138,824...35,143,109
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|
G |
G6PD |
glucose-6-phosphate dehydrogenase |
increases expression |
ISO EXP |
Amiodarone results in increased expression of G6PDX mRNA Amiodarone results in increased expression of G6PD mRNA |
CTD |
PMID:19224547 PMID:19774075 |
|
NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572
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G |
GADD45A |
growth arrest and DNA damage inducible alpha |
increases expression |
EXP |
Amiodarone results in increased expression of GADD45A mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
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G |
GADD45G |
growth arrest and DNA damage inducible gamma |
increases expression |
EXP |
Amiodarone results in increased expression of GADD45G mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 9:89,605,012...89,606,555
Ensembl chr 9:89,605,012...89,606,555
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|
G |
GAL |
galanin and GMAP prepropeptide |
increases expression |
ISO |
Amiodarone results in increased expression of GAL mRNA |
CTD |
PMID:25580480 |
|
NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
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|
G |
GAL3ST3 |
galactose-3-O-sulfotransferase 3 |
increases expression |
EXP |
Amiodarone results in increased expression of GAL3ST3 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr11:66,040,765...66,049,161
Ensembl chr11:66,040,765...66,049,161
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|
G |
GALNT17 |
polypeptide N-acetylgalactosaminyltransferase 17 |
increases expression |
EXP |
Amiodarone results in increased expression of GALNT17 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 7:71,132,144...71,713,599
Ensembl chr 7:71,132,144...71,713,600
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G |
GAMT |
guanidinoacetate N-methyltransferase |
affects expression |
ISO |
Amiodarone affects the expression of GAMT mRNA |
CTD |
PMID:19483382 |
|
NCBI chr19:1,397,026...1,401,542
Ensembl chr19:1,397,026...1,401,570
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|
G |
GAPDH |
glyceraldehyde-3-phosphate dehydrogenase |
affects expression |
ISO |
Amiodarone affects the expression of GAPDH mRNA |
CTD |
PMID:19483382 |
|
NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
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|
G |
GATA2 |
GATA binding protein 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of GATA2 mRNA |
CTD |
PMID:17991464 |
|
NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
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G |
GATB |
glutamyl-tRNA amidotransferase subunit B |
increases expression |
ISO |
Amiodarone results in increased expression of GATB mRNA |
CTD |
PMID:24535564 |
|
NCBI chr 4:151,670,504...151,761,007
Ensembl chr 4:151,670,504...151,761,007
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|
G |
GBE1 |
1,4-alpha-glucan branching enzyme 1 |
affects expression |
ISO |
Amiodarone affects the expression of GBE1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 3:81,489,703...81,761,645
Ensembl chr 3:81,489,703...81,761,645
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|
G |
GBP2 |
guanylate binding protein 2 |
increases expression |
EXP |
Amiodarone results in increased expression of GBP2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:89,106,132...89,126,114
Ensembl chr 1:89,106,132...89,150,456
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G |
GCHFR |
GTP cyclohydrolase I feedback regulator |
affects expression |
ISO |
Amiodarone affects the expression of GCHFR mRNA |
CTD |
PMID:19483382 |
|
NCBI chr15:40,764,068...40,767,708
Ensembl chr15:40,764,068...40,767,708
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|
G |
GCKR |
glucokinase regulator |
affects expression |
ISO |
Amiodarone affects the expression of GCKR mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 2:27,496,839...27,523,684
Ensembl chr 2:27,496,839...27,523,684
|
|
G |
GCLM |
glutamate-cysteine ligase modifier subunit |
increases expression |
EXP |
Amiodarone results in increased expression of GCLM mRNA |
CTD |
PMID:36586010 |
|
NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
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|
G |
GDF15 |
growth differentiation factor 15 |
increases expression |
EXP |
Amiodarone results in increased expression of GDF15 mRNA |
CTD |
PMID:19774075 PMID:36586010 |
|
NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
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G |
GDF5 |
growth differentiation factor 5 |
increases expression |
EXP |
Amiodarone results in increased expression of GDF5 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr20:35,433,347...35,454,749
Ensembl chr20:35,433,347...35,454,746
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G |
GDPD3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
EXP |
Amiodarone results in increased expression of GDPD3 mRNA |
CTD |
PMID:17175557 PMID:17567588 |
|
NCBI chr16:30,104,810...30,113,537
Ensembl chr16:30,104,810...30,113,537
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G |
GEM |
GTP binding protein overexpressed in skeletal muscle |
increases expression |
EXP |
Amiodarone results in increased expression of GEM mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 8:94,249,253...94,262,319
Ensembl chr 8:94,249,253...94,262,350
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G |
GFAP |
glial fibrillary acidic protein |
increases expression |
ISO |
Amiodarone results in increased expression of GFAP mRNA |
CTD |
PMID:22954530 PMID:25659768 |
|
NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GFOD1 |
Gfo/Idh/MocA-like oxidoreductase domain containing 1 |
increases expression |
EXP |
Amiodarone results in increased expression of GFOD1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 6:13,357,830...13,487,600
Ensembl chr 6:13,357,830...13,487,662
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G |
GGH |
gamma-glutamyl hydrolase |
affects expression |
ISO |
Amiodarone affects the expression of GGH mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 8:63,015,079...63,038,806
Ensembl chr 8:63,014,881...63,039,407
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G |
GH1 |
growth hormone 1 |
multiple interactions |
ISO |
Amiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA] |
CTD |
PMID:2910914 |
|
NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
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|
G |
GINS1 |
GINS complex subunit 1 |
increases expression |
EXP |
Amiodarone results in increased expression of GINS1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr20:25,407,673...25,448,563
Ensembl chr20:25,391,008...25,452,700
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G |
GJA1 |
gap junction protein alpha 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of GJA1 mRNA |
CTD |
PMID:15520326 |
|
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
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G |
GJA5 |
gap junction protein alpha 5 |
increases expression |
EXP |
Amiodarone results in increased expression of GJA5 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
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G |
GJB1 |
gap junction protein beta 1 |
affects expression |
ISO |
Amiodarone affects the expression of GJB1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr X:71,215,239...71,225,516
Ensembl chr X:71,212,811...71,225,516
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G |
GJD3 |
gap junction protein delta 3 |
increases expression |
EXP |
Amiodarone results in increased expression of GJD3 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737
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G |
GK5 |
glycerol kinase 5 |
increases expression |
EXP |
Amiodarone results in increased expression of GK5 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 3:142,157,527...142,225,585
Ensembl chr 3:142,157,527...142,225,592
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G |
GKAP1 |
G kinase anchoring protein 1 |
increases expression |
EXP |
Amiodarone results in increased expression of GKAP1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 9:83,739,425...83,817,769
Ensembl chr 9:83,739,425...83,829,516
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G |
GLS2 |
glutaminase 2 |
affects expression |
ISO |
Amiodarone affects the expression of GLS2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr12:56,470,952...56,488,161
Ensembl chr12:56,470,944...56,488,414
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G |
GLUD1 |
glutamate dehydrogenase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of GLUD1 protein |
CTD |
PMID:16538043 |
|
NCBI chr10:87,050,202...87,094,843
Ensembl chr10:87,050,202...87,094,843
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G |
GNAS |
GNAS complex locus |
increases expression |
EXP |
Amiodarone results in increased expression of GNAS mRNA |
CTD |
PMID:19774075 |
|
NCBI chr20:58,839,748...58,911,192
Ensembl chr20:58,839,718...58,911,192
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G |
GNL1 |
G protein nucleolar 1 (putative) |
decreases expression |
ISO |
Amiodarone results in decreased expression of GNL1 mRNA |
CTD |
PMID:17991464 |
|
NCBI chr 6:30,541,381...30,556,489
Ensembl chr 6:30,541,381...30,556,489
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G |
GNPAT |
glyceronephosphate O-acyltransferase |
increases expression |
ISO |
Amiodarone results in increased expression of GNPAT mRNA |
CTD |
PMID:22291062 |
|
NCBI chr 1:231,241,212...231,277,973
Ensembl chr 1:231,241,207...231,277,973
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G |
GON4L |
gon-4 like |
increases expression |
EXP |
Amiodarone results in increased expression of GON4L mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 1:155,745,112...155,859,431
Ensembl chr 1:155,749,659...155,859,400
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G |
GOT2 |
glutamic-oxaloacetic transaminase 2 |
affects expression |
ISO |
Amiodarone affects the expression of GOT2 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
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G |
GPAM |
glycerol-3-phosphate acyltransferase, mitochondrial |
increases expression |
ISO |
Amiodarone results in increased expression of GPAM mRNA |
CTD |
PMID:19224547 |
|
NCBI chr10:112,149,865...112,227,677
Ensembl chr10:112,149,865...112,215,377
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G |
GPAT3 |
glycerol-3-phosphate acyltransferase 3 |
increases expression |
ISO |
Amiodarone results in increased expression of GPAT3 mRNA |
CTD |
PMID:24535564 |
|
NCBI chr 4:83,535,587...83,605,875
Ensembl chr 4:83,535,914...83,605,875
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G |
GPLD1 |
glycosylphosphatidylinositol specific phospholipase D1 |
affects expression |
ISO |
Amiodarone affects the expression of GPLD1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 6:24,423,969...24,495,287
Ensembl chr 6:24,424,565...24,495,205
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G |
GPRC5C |
G protein-coupled receptor class C group 5 member C |
increases expression |
EXP |
Amiodarone results in increased expression of GPRC5C mRNA |
CTD |
PMID:19774075 |
|
NCBI chr17:74,432,088...74,451,658
Ensembl chr17:74,424,851...74,451,653
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G |
GPT |
glutamic--pyruvic transaminase |
increases expression multiple interactions increases activity |
EXP ISO |
Amiodarone results in increased expression of GPT protein 1-aminobenzotriazole promotes the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]; [Dexamethasone results in increased susceptibility to Amiodarone] which results in increased expression of GPT protein; Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]; gadolinium chloride inhibits the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]] Amiodarone results in increased activity of GPT protein |
CTD |
PMID:8522712 PMID:22291062 PMID:24685772 PMID:25900201 PMID:32084307 PMID:34259586 More...
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|
NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
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G |
GPT2 |
glutamic--pyruvic transaminase 2 |
increases expression |
ISO |
Amiodarone results in increased expression of GPT2 mRNA |
CTD |
PMID:24489787 |
|
NCBI chr16:46,884,362...46,931,289
Ensembl chr16:46,884,362...46,931,289
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G |
GPX1 |
glutathione peroxidase 1 |
affects expression decreases expression multiple interactions |
ISO EXP |
Amiodarone affects the expression of GPX1 mRNA Amiodarone results in decreased expression of GPX1 mRNA ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of GPX1 mRNA]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of GPX1 mRNA]] |
CTD |
PMID:19483382 PMID:34434487 |
|
NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
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G |
GPX4 |
glutathione peroxidase 4 |
affects expression |
ISO |
Amiodarone affects the expression of GPX4 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
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G |
GRB14 |
growth factor receptor bound protein 14 |
affects expression |
ISO |
Amiodarone affects the expression of GRB14 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 2:164,492,417...164,621,482
Ensembl chr 2:164,492,417...164,621,482
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G |
GRINA |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
affects expression |
ISO |
Amiodarone affects the expression of GRINA mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 8:143,990,056...143,993,415
Ensembl chr 8:143,990,056...143,993,415
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G |
GRM2 |
glutamate metabotropic receptor 2 |
increases expression |
EXP |
Amiodarone results in increased expression of GRM2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 3:51,707,068...51,718,613
Ensembl chr 3:51,707,068...51,718,613
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G |
GRPEL1 |
GrpE like 1, mitochondrial |
affects expression |
ISO |
Amiodarone affects the expression of GRPEL1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 4:7,058,895...7,068,064
Ensembl chr 4:7,058,671...7,068,085
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G |
GSK3B |
glycogen synthase kinase 3 beta |
decreases phosphorylation |
EXP ISO |
Amiodarone results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:26515726 |
|
NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
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G |
GSN |
gelsolin |
increases expression |
ISO |
Amiodarone results in increased expression of GSN mRNA |
CTD |
PMID:17991464 |
|
NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843
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G |
GSTA2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
Amiodarone results in increased expression of GSTA2 mRNA |
CTD |
PMID:36586010 |
|
NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
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G |
GSTO2 |
glutathione S-transferase omega 2 |
increases expression |
EXP |
Amiodarone results in increased expression of GSTO2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr10:104,269,184...104,304,950
Ensembl chr10:104,268,873...104,304,950
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G |
GSTT1 |
glutathione S-transferase theta 1 |
affects expression |
ISO |
Amiodarone affects the expression of GSTT1 mRNA |
CTD |
PMID:19483382 |
|
|
|
G |
GSTT2B |
glutathione S-transferase theta 2B |
increases expression |
ISO |
Amiodarone results in increased expression of GSTT2 mRNA |
CTD |
PMID:24535564 |
|
NCBI chr22:23,957,414...23,961,206
Ensembl chr22:23,957,414...23,961,195
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G |
GSTT3P |
glutathione S-transferase theta 3, pseudogene |
increases expression |
ISO |
Amiodarone results in increased expression of GSTT3 mRNA |
CTD |
PMID:24535564 |
|
|
|
G |
GSTZ1 |
glutathione S-transferase zeta 1 |
increases expression |
EXP |
Amiodarone results in increased expression of GSTZ1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597
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|
G |
GTF2H5 |
general transcription factor IIH subunit 5 |
affects expression |
ISO |
Amiodarone affects the expression of GTF2H5 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 6:158,168,350...158,199,344
Ensembl chr 6:158,168,350...158,199,344
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|
G |
GUCY1A2 |
guanylate cyclase 1 soluble subunit alpha 2 |
increases expression |
EXP |
Amiodarone results in increased expression of GUCY1A2 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr11:106,674,019...107,018,476
Ensembl chr11:106,674,019...107,018,476
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|
G |
GUCY1B1 |
guanylate cyclase 1 soluble subunit beta 1 |
increases expression |
EXP |
Amiodarone results in increased expression of GUCY1B1 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811
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|
G |
GZMA |
granzyme A |
affects expression |
ISO |
Amiodarone affects the expression of GZMA mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 5:55,102,646...55,110,252
Ensembl chr 5:55,102,646...55,110,252
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|
G |
H2AC17 |
H2A clustered histone 17 |
increases expression |
EXP |
Amiodarone results in increased expression of H2AC17 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 6:27,892,699...27,893,185
Ensembl chr 6:27,892,699...27,893,185
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G |
H2AJ |
H2A.J histone |
increases expression |
EXP |
Amiodarone results in increased expression of H2AJ mRNA |
CTD |
PMID:19774075 |
|
NCBI chr12:14,774,405...14,778,002
Ensembl chr12:14,774,405...14,778,002
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|
G |
H2BC6 |
H2B clustered histone 6 |
increases expression |
EXP |
Amiodarone results in increased expression of H2BC6 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 6:26,183,761...26,184,230
Ensembl chr 6:26,172,059...26,184,655
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|
G |
H3-3B |
H3.3 histone B |
affects expression |
ISO |
Amiodarone affects the expression of H3F3B mRNA |
CTD |
PMID:19483382 |
|
NCBI chr17:75,776,434...75,779,779
Ensembl chr17:75,776,434...75,785,893
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|
G |
H3C11 |
H3 clustered histone 11 |
increases expression |
EXP |
Amiodarone results in increased expression of H3C11 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 6:27,871,845...27,872,346
Ensembl chr 6:27,871,845...27,872,346
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|
G |
H3C12 |
H3 clustered histone 12 |
increases expression |
EXP |
Amiodarone results in increased expression of H3C12 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:27,890,315...27,890,826
Ensembl chr 6:27,890,315...27,893,106
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G |
H4C8 |
H4 clustered histone 8 |
increases expression |
EXP |
Amiodarone results in increased expression of H4C8 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:26,285,126...26,285,534
Ensembl chr 6:26,277,609...26,285,638
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G |
HAL |
histidine ammonia-lyase |
affects expression |
ISO |
Amiodarone affects the expression of HAL mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365
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G |
HAO2 |
hydroxyacid oxidase 2 |
affects expression |
ISO |
Amiodarone affects the expression of HAO2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:119,368,785...119,394,130
Ensembl chr 1:119,368,779...119,394,130
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G |
HBA1 |
hemoglobin subunit alpha 1 |
affects expression |
ISO |
Amiodarone affects the expression of HBA-A2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
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G |
HBB |
hemoglobin subunit beta |
affects expression |
ISO |
Amiodarone affects the expression of HBB mRNA |
CTD |
PMID:19483382 |
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NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
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G |
HCN1 |
hyperpolarization activated cyclic nucleotide gated potassium channel 1 |
increases expression |
EXP |
Amiodarone results in increased expression of HCN1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498
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G |
HCN2 |
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of HCN2 mRNA |
CTD |
PMID:17711693 |
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NCBI chr19:589,881...617,159
Ensembl chr19:589,881...617,159
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G |
HCN4 |
hyperpolarization activated cyclic nucleotide gated potassium channel 4 |
decreases expression |
ISO |
Amiodarone results in decreased expression of HCN4 mRNA |
CTD |
PMID:17711693 |
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NCBI chr15:73,319,859...73,368,958
Ensembl chr15:73,319,859...73,368,958
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G |
HDC |
histidine decarboxylase |
affects expression |
ISO |
Amiodarone affects the expression of HDC mRNA |
CTD |
PMID:19483382 |
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NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965
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G |
HDX |
highly divergent homeobox |
increases expression |
EXP |
Amiodarone results in increased expression of HDX mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:84,317,878...84,502,453
Ensembl chr X:84,317,874...84,502,479
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G |
HELB |
DNA helicase B |
increases expression |
EXP |
Amiodarone results in increased expression of HELB mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:66,302,493...66,343,643
Ensembl chr12:66,302,493...66,343,643
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G |
HERPUD1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
EXP |
Amiodarone results in increased expression of HERPUD1 mRNA |
CTD |
PMID:19774075 PMID:36586010 |
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NCBI chr16:56,932,142...56,944,864
Ensembl chr16:56,932,142...56,944,864
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G |
HES6 |
hes family bHLH transcription factor 6 |
decreases expression |
ISO |
Amiodarone results in decreased expression of HES6 mRNA |
CTD |
PMID:17991464 |
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NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662
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G |
HEXA |
hexosaminidase subunit alpha |
multiple interactions increases expression |
EXP |
Amiodarone results in increased activity of and results in increased secretion of HEXA protein Amiodarone results in increased expression of HEXA mRNA |
CTD |
PMID:25881747 |
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NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,924...72,376,420
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G |
HEXB |
hexosaminidase subunit beta |
multiple interactions |
EXP |
Amiodarone results in increased activity of and results in increased secretion of HEXB protein |
CTD |
PMID:25881747 |
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NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
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G |
HEXIM1 |
HEXIM P-TEFb complex subunit 1 |
increases expression |
EXP |
Amiodarone results in increased expression of HEXIM1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:45,148,475...45,152,099
Ensembl chr17:45,148,475...45,152,099
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G |
HGD |
homogentisate 1,2-dioxygenase |
affects expression |
ISO |
Amiodarone affects the expression of HGD mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:120,628,172...120,682,239
Ensembl chr 3:120,628,172...120,682,269
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G |
HGFAC |
HGF activator |
increases expression |
EXP |
Amiodarone results in increased expression of HGFAC mRNA |
CTD |
PMID:19774075 |
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NCBI chr 4:3,441,005...3,449,486
Ensembl chr 4:3,441,968...3,449,486
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
EXP |
Amiodarone results in decreased expression of HIF1A mRNA |
CTD |
PMID:35641671 |
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NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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G |
HIRA |
histone cell cycle regulator |
increases expression |
EXP |
Amiodarone results in increased expression of HIRA mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:19,330,698...19,431,733
Ensembl chr22:19,330,698...19,447,450
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G |
HJV |
hemojuvelin BMP co-receptor |
increases expression |
ISO |
Amiodarone results in increased expression of HJV mRNA |
CTD |
PMID:24535564 |
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NCBI chr 1:146,017,470...146,021,735
Ensembl chr 1:146,017,468...146,036,746
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G |
HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
increases expression |
EXP |
Amiodarone results in increased expression of HLA-DPB1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696
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G |
HMGB2 |
high mobility group box 2 |
affects expression |
ISO |
Amiodarone affects the expression of HMGB2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
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G |
HMGCR |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
ISO |
Amiodarone results in increased expression of HMGCR mRNA |
CTD |
PMID:24489787 |
|
NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
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G |
HMGCS1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of HMGCS1 mRNA |
CTD |
PMID:22291062 |
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NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512
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G |
HMGN1 |
high mobility group nucleosome binding domain 1 |
affects expression |
ISO |
Amiodarone affects the expression of HMGN1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr21:39,342,315...39,349,088
Ensembl chr21:39,342,315...39,349,647
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G |
HMGXB4 |
HMG-box containing 4 |
increases expression |
EXP |
Amiodarone results in increased expression of HMGXB4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:35,241,536...35,295,807
Ensembl chr22:35,257,452...35,295,807
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G |
HMOX1 |
heme oxygenase 1 |
increases expression affects expression |
EXP ISO |
Amiodarone results in increased expression of HMOX1 mRNA Amiodarone affects the expression of HMOX1 mRNA |
CTD |
PMID:18020914 PMID:19224547 PMID:19774075 PMID:25659768 PMID:31324950 PMID:36586010 More...
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HNF4A |
hepatocyte nuclear factor 4 alpha |
increases expression |
ISO |
Amiodarone results in increased expression of HNF4A mRNA |
CTD |
PMID:24489787 |
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NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845
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G |
HNF4G |
hepatocyte nuclear factor 4 gamma |
increases expression |
EXP |
Amiodarone results in increased expression of HNF4G mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:75,407,649...75,566,834
Ensembl chr 8:75,407,914...75,566,834
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G |
HNRNPA1 |
heterogeneous nuclear ribonucleoprotein A1 |
increases expression |
EXP |
Amiodarone results in increased expression of HNRNPA1 mRNA |
CTD |
PMID:21163907 |
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NCBI chr12:54,280,726...54,287,087
Ensembl chr12:54,280,193...54,287,088
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G |
HOXB6 |
homeobox B6 |
increases expression |
EXP |
Amiodarone results in increased expression of HOXB6 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:48,595,751...48,604,986
Ensembl chr17:48,595,751...48,604,992
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G |
HOXC4 |
homeobox C4 |
increases expression |
EXP |
Amiodarone results in increased expression of HOXC4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:54,016,888...54,056,030
Ensembl chr12:54,016,931...54,056,030
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G |
HPN |
hepsin |
increases expression |
EXP |
Amiodarone results in increased expression of HPN mRNA |
CTD |
PMID:15342952 PMID:17567588 |
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NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,573
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G |
HPRT1 |
hypoxanthine phosphoribosyltransferase 1 |
affects expression |
ISO |
Amiodarone affects the expression of HPRT1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513
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G |
HPS5 |
HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 |
affects expression |
ISO |
Amiodarone affects the expression of HPS5 mRNA |
CTD |
PMID:19483382 |
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NCBI chr11:18,278,670...18,322,174
Ensembl chr11:18,278,668...18,322,198
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G |
HRK |
harakiri, BCL2 interacting protein |
increases expression |
EXP |
Amiodarone results in increased expression of HRK mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:116,856,144...116,881,441
Ensembl chr12:116,856,144...116,881,441
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G |
HSCB |
HscB mitochondrial iron-sulfur cluster cochaperone |
increases expression |
ISO |
Amiodarone results in increased expression of HSCB mRNA |
CTD |
PMID:24535564 |
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NCBI chr22:28,742,032...28,757,510
Ensembl chr22:28,742,039...28,757,515
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G |
HSD17B11 |
hydroxysteroid 17-beta dehydrogenase 11 |
increases expression |
ISO |
Amiodarone results in increased expression of HSD17B11 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 4:87,336,515...87,391,188
Ensembl chr 4:87,336,515...87,391,188
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G |
HSD17B4 |
hydroxysteroid 17-beta dehydrogenase 4 |
affects expression |
ISO |
Amiodarone affects the expression of HSD17B4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 5:119,452,497...119,542,332
Ensembl chr 5:119,452,465...119,637,199
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G |
HSDL2 |
hydroxysteroid dehydrogenase like 2 |
affects expression |
ISO |
Amiodarone affects the expression of HSDL2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 9:112,380,108...112,472,405
Ensembl chr 9:112,380,080...112,472,405
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
EXP ISO |
Amiodarone results in increased expression of HSPA5 mRNA; Amiodarone results in increased expression of HSPA5 protein 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of HSPA5 mRNA] 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Amiodarone results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Amiodarone results in increased expression of HSPA5 protein] |
CTD |
PMID:25295624 PMID:34259586 PMID:36586010 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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G |
HSPD1 |
heat shock protein family D (Hsp60) member 1 |
increases expression |
ISO |
Amiodarone results in increased expression of HSPD1 protein |
CTD |
PMID:16538043 |
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NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
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G |
HTATIP2 |
HIV-1 Tat interactive protein 2 |
increases expression |
ISO |
Amiodarone results in increased expression of HTATIP2 mRNA |
CTD |
PMID:24535564 |
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NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,782
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G |
HTRA1 |
HtrA serine peptidase 1 |
affects expression |
ISO |
Amiodarone affects the expression of HTRA1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr10:122,461,553...122,514,907
Ensembl chr10:122,458,551...122,514,907
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G |
HTRA2 |
HtrA serine peptidase 2 |
increases expression |
ISO |
Amiodarone results in increased expression of HTRA2 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,596...74,533,350
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G |
HUS1 |
HUS1 checkpoint clamp component |
increases expression |
EXP |
Amiodarone results in increased expression of HUS1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 7:47,963,288...47,979,615
Ensembl chr 7:47,961,882...47,979,615
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G |
ICAM1 |
intercellular adhesion molecule 1 |
increases expression multiple interactions |
EXP |
Amiodarone results in increased expression of ICAM1 mRNA [Amiodarone co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein |
CTD |
PMID:19774075 PMID:22785256 |
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NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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G |
ID2 |
inhibitor of DNA binding 2 |
increases expression |
EXP |
Amiodarone results in increased expression of ID2 mRNA |
CTD |
PMID:23397585 |
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NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
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G |
IDH2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases expression |
ISO |
Amiodarone results in increased expression of IDH2 mRNA |
CTD |
PMID:24489787 |
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NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
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G |
IFNG |
interferon gamma |
multiple interactions decreases expression |
ISO EXP |
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]; Losartan inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]; Prednisolone inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]; Vitamin D inhibits the reaction [Amiodarone results in decreased expression of IFNG protein] Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG protein] |
CTD |
PMID:25073960 PMID:34590760 |
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NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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G |
IGF1 |
insulin like growth factor 1 |
affects expression |
ISO |
Amiodarone affects the expression of IGF1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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G |
IGFALS |
insulin like growth factor binding protein acid labile subunit |
increases expression affects expression |
EXP ISO |
Amiodarone results in increased expression of IGFALS mRNA Amiodarone affects the expression of IGFALS mRNA |
CTD |
PMID:19483382 PMID:19774075 |
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NCBI chr16:1,790,413...1,794,908
Ensembl chr16:1,790,413...1,794,971
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G |
IGFBP1 |
insulin like growth factor binding protein 1 |
increases expression |
EXP |
Amiodarone results in increased expression of IGFBP1 mRNA |
CTD |
PMID:27089845 |
|
NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
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G |
IGFBP2 |
insulin like growth factor binding protein 2 |
affects expression |
ISO |
Amiodarone affects the expression of IGFBP2 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436
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G |
IGSF8 |
immunoglobulin superfamily member 8 |
increases expression |
EXP |
Amiodarone results in increased expression of IGSF8 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:160,091,339...160,099,468
Ensembl chr 1:160,091,340...160,098,943
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G |
IL10 |
interleukin 10 |
decreases expression multiple interactions |
EXP |
Amiodarone results in decreased expression of IL10 mRNA; Amiodarone results in decreased expression of IL10 protein ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in decreased expression of IL10 mRNA]] |
CTD |
PMID:34434487 |
|
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL10RA |
interleukin 10 receptor subunit alpha |
increases expression |
EXP |
Amiodarone results in increased expression of IL10RA mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:117,986,394...118,003,037
Ensembl chr11:117,986,370...118,003,037
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G |
IL18 |
interleukin 18 |
multiple interactions |
ISO |
Amiodarone promotes the reaction [Dexamethasone results in decreased expression of IL18 mRNA] |
CTD |
PMID:25900201 |
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NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
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G |
IL1A |
interleukin 1 alpha |
increases expression multiple interactions |
EXP |
Amiodarone results in increased expression of IL1A mRNA [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Amiodarone |
CTD |
PMID:19362101 PMID:19774075 |
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NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
IL1B |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
[Amiodarone co-treated with Dexamethasone] results in decreased expression of IL1B mRNA ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL1B mRNA]] Amiodarone results in increased expression of IL1B mRNA; Amiodarone results in increased expression of IL1B protein |
CTD |
PMID:25580480 PMID:25900201 PMID:34434487 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL2 |
interleukin 2 |
multiple interactions |
EXP |
Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 protein] |
CTD |
PMID:25073960 |
|
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
IL33 |
interleukin 33 |
affects expression |
ISO |
Amiodarone affects the expression of IL33 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
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G |
IL4 |
interleukin 4 |
multiple interactions |
ISO EXP |
[Vitamin D co-treated with Losartan] inhibits the reaction [Amiodarone results in increased expression of IL4 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL4 protein]; Prednisolone inhibits the reaction [Amiodarone results in increased expression of IL4 protein]; Vitamin D inhibits the reaction [Amiodarone results in increased expression of IL4 protein] Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein] |
CTD |
PMID:25073960 PMID:34590760 |
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NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL6 |
interleukin 6 |
increases expression multiple interactions increases secretion |
EXP ISO |
Amiodarone results in increased expression of IL6 mRNA; Amiodarone results in increased expression of IL6 protein [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Prednisolone inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Vitamin D inhibits the reaction [Amiodarone results in increased expression of IL6 protein] [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Amiodarone; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 mRNA]; ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; CTNNB1 protein affects the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 protein]]; IWR-1 compound inhibits the reaction [ADM2 protein inhibits the reaction [Amiodarone results in increased expression of IL6 mRNA]]; Prednisolone inhibits the reaction [Amiodarone results in increased secretion of IL6 protein] |
CTD |
PMID:11288978 PMID:19362101 PMID:34434487 PMID:34590760 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
IMPA1 |
inositol monophosphatase 1 |
affects expression |
ISO |
Amiodarone affects the expression of IMPA1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 8:81,656,914...81,686,325
Ensembl chr 8:81,656,914...81,686,331
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INHBA |
inhibin subunit beta A |
decreases expression |
ISO |
Amiodarone results in decreased expression of INHBA mRNA |
CTD |
PMID:24535564 |
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NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834
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INHBE |
inhibin subunit beta E |
affects expression increases expression |
ISO EXP |
Amiodarone affects the expression of INHBE mRNA Amiodarone results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 PMID:19483382 PMID:19774075 |
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NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
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INKA2 |
inka box actin regulator 2 |
increases expression |
EXP |
Amiodarone results in increased expression of INKA2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:111,722,064...111,755,797
Ensembl chr 1:111,680,630...111,755,824
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INS |
insulin |
multiple interactions |
ISO |
INS inhibits the reaction [Amiodarone results in increased phosphorylation of LIPE protein] |
CTD |
PMID:28962527 |
|
NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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IPPK |
inositol-pentakisphosphate 2-kinase |
increases expression |
EXP |
Amiodarone results in increased expression of IPPK mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:92,613,183...92,670,131
Ensembl chr 9:92,613,183...92,670,131
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G |
IRAK2 |
interleukin 1 receptor associated kinase 2 |
increases expression |
EXP |
Amiodarone results in increased expression of IRAK2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745
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IRF1 |
interferon regulatory factor 1 |
increases expression |
EXP |
Amiodarone results in increased expression of IRF1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719
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G |
ISX |
intestine specific homeobox |
increases expression |
EXP |
Amiodarone results in increased expression of ISX mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:35,066,158...35,087,387
Ensembl chr22:35,066,136...35,087,387
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G |
ISYNA1 |
inositol-3-phosphate synthase 1 |
affects expression |
ISO |
Amiodarone affects the expression of ISYNA1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:18,434,388...18,438,133
Ensembl chr19:18,434,388...18,438,167
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G |
ITGB5 |
integrin subunit beta 5 |
decreases expression |
EXP |
Amiodarone results in decreased expression of ITGB5 mRNA |
CTD |
PMID:23397585 |
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NCBI chr 3:124,761,948...124,901,418
Ensembl chr 3:124,761,948...124,901,418
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G |
ITIH2 |
inter-alpha-trypsin inhibitor heavy chain 2 |
increases expression |
EXP |
Amiodarone results in increased expression of ITIH2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:7,703,316...7,749,520
Ensembl chr10:7,703,316...7,749,520
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G |
ITIH4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
affects expression |
ISO |
Amiodarone affects the expression of ITIH4 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688
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G |
IVNS1ABP |
influenza virus NS1A binding protein |
increases expression |
ISO |
Amiodarone results in increased expression of IVNS1ABP mRNA |
CTD |
PMID:17991464 |
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NCBI chr 1:185,296,388...185,317,243
Ensembl chr 1:185,292,931...185,317,273
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G |
JAK1 |
Janus kinase 1 |
affects expression |
ISO |
Amiodarone affects the expression of JAK1 mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754
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G |
JAKMIP3 |
Janus kinase and microtubule interacting protein 3 |
increases expression |
EXP |
Amiodarone results in increased expression of JAKMIP3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:132,036,364...132,184,858
Ensembl chr10:132,036,336...132,184,858
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JRKL |
JRK like |
increases expression |
EXP |
Amiodarone results in increased expression of JRKL mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:96,390,013...96,393,561
Ensembl chr11:96,389,989...96,507,574
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression increases phosphorylation multiple interactions |
ISO EXP |
Amiodarone results in increased expression of JUN mRNA; Amiodarone results in increased expression of JUN protein Amiodarone results in increased phosphorylation of JUN protein [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]; Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]; Vitamin D inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein] [FOS protein co-treated with JUN protein] promotes the reaction [Amiodarone results in increased expression of AGT mRNA]; Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of JUN protein] |
CTD |
PMID:11597910 PMID:17214612 PMID:25073960 PMID:34590760 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
KCNA4 |
potassium voltage-gated channel subfamily A member 4 |
increases expression |
ISO |
Amiodarone results in increased expression of KCNA4 mRNA |
CTD |
PMID:15520326 |
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NCBI chr11:30,009,730...30,017,030
Ensembl chr11:30,009,730...30,017,030
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G |
KCNA5 |
potassium voltage-gated channel subfamily A member 5 |
decreases expression |
ISO |
Amiodarone results in decreased expression of KCNA5 mRNA |
CTD |
PMID:8973384 PMID:9302343 PMID:15520326 |
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NCBI chr12:5,043,879...5,046,788
Ensembl chr12:5,043,879...5,046,788
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G |
KCNAB1 |
potassium voltage-gated channel subfamily A regulatory beta subunit 1 |
increases expression |
ISO |
Amiodarone results in increased expression of KCNAB1 mRNA |
CTD |
PMID:15520326 |
|
NCBI chr 3:156,118,211...156,539,138
Ensembl chr 3:156,037,701...156,538,756
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G |
KCNB1 |
potassium voltage-gated channel subfamily B member 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of KCNB1 mRNA |
CTD |
PMID:15520326 |
|
NCBI chr20:49,363,877...49,483,362
Ensembl chr20:49,293,394...49,484,297
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G |
KCND2 |
potassium voltage-gated channel subfamily D member 2 |
decreases expression |
ISO |
Amiodarone results in decreased expression of KCND2 mRNA |
CTD |
PMID:15520326 |
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NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337
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G |
KCNE3 |
potassium voltage-gated channel subfamily E regulatory subunit 3 |
increases expression |
ISO |
Amiodarone results in increased expression of KCNE3 mRNA |
CTD |
PMID:15520326 |
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NCBI chr11:74,454,841...74,467,549
Ensembl chr11:74,454,841...74,467,729
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G |
KCNE5 |
potassium voltage-gated channel subfamily E regulatory subunit 5 |
increases expression |
EXP |
Amiodarone results in increased expression of KCNE5 mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:109,623,700...109,625,172
Ensembl chr X:109,623,700...109,625,172
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G |
KCNH2 |
potassium voltage-gated channel subfamily H member 2 |
affects activity increases expression decreases activity multiple interactions |
EXP ISO |
Amiodarone affects the activity of KCNH2 protein Amiodarone results in increased expression of KCNH2 mRNA Amiodarone results in decreased activity of KCNH2 protein Amiodarone binds to and results in decreased activity of KCNH2 protein; Amiodarone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Amiodarone results in decreased activity of KCNH2 protein] |
CTD |
PMID:10208308 PMID:11238279 PMID:15272206 PMID:15618689 PMID:15671647 PMID:15821840 PMID:16960444 PMID:16971508 PMID:18057881 PMID:18724381 PMID:19583963 PMID:21158687 PMID:22020101 PMID:22291062 PMID:24052561 More...
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NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
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G |
KCNJ2 |
potassium inwardly rectifying channel subfamily J member 2 |
increases expression |
EXP |
Amiodarone results in increased expression of KCNJ2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044
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G |
KCNK1 |
potassium two pore domain channel subfamily K member 1 |
increases expression |
ISO |
Amiodarone results in increased expression of KCNK1 mRNA |
CTD |
PMID:15520326 |
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NCBI chr 1:233,614,106...233,672,514
Ensembl chr 1:233,614,106...233,672,514
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G |
KCNK12 |
potassium two pore domain channel subfamily K member 12 |
increases expression |
EXP |
Amiodarone results in increased expression of KCNK12 mRNA |
CTD |
PMID:19774075 |
|
NCBI chr 2:47,509,290...47,570,985
Ensembl chr 2:47,509,290...47,570,985
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G |
KCNMA1 |
potassium calcium-activated channel subfamily M alpha 1 |
increases expression |
EXP |
Amiodarone results in increased expression of KCNMA1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr10:76,869,602...77,637,808
Ensembl chr10:76,869,601...77,638,369
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G |
KCTD14 |
potassium channel tetramerization domain containing 14 |
increases expression |
EXP |
Amiodarone results in increased expression of KCTD14 mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:78,015,715...78,046,191
Ensembl chr11:78,015,715...78,046,191
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KDELR2 |
KDEL endoplasmic reticulum protein retention receptor 2 |
affects expression |
ISO |
Amiodarone affects the expression of KDELR2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 7:6,461,089...6,484,152
Ensembl chr 7:6,445,953...6,484,190
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G |
KDR |
kinase insert domain receptor |
affects expression |
ISO |
Amiodarone affects the expression of KDR mRNA |
CTD |
PMID:19483382 |
|
NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
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G |
KEAP1 |
kelch like ECH associated protein 1 |
decreases expression |
ISO |
Amiodarone results in decreased expression of KEAP1 mRNA |
CTD |
PMID:17991464 |
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NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
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G |
KHDRBS3 |
KH RNA binding domain containing, signal transduction associated 3 |
increases expression |
ISO |
Amiodarone results in increased expression of KHDRBS3 mRNA |
CTD |
PMID:24535564 |
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NCBI chr 8:135,457,456...135,656,516
Ensembl chr 8:135,457,456...135,656,722
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G |
KIF16B |
kinesin family member 16B |
increases expression |
EXP |
Amiodarone results in increased expression of KIF16B mRNA |
CTD |
PMID:19774075 |
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NCBI chr20:16,272,104...16,573,448
Ensembl chr20:16,272,104...16,573,448
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G |
KIF17 |
kinesin family member 17 |
increases expression |
EXP |
Amiodarone results in increased expression of KIF17 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:20,661,630...20,718,007
Ensembl chr 1:20,664,014...20,718,017
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G |
KIFC1 |
kinesin family member C1 |
increases expression |
EXP |
Amiodarone results in increased expression of KIFC1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:33,391,461...33,409,896
Ensembl chr 6:33,391,823...33,409,896
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G |
KIR2DL5B |
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B |
increases expression |
EXP |
Amiodarone results in increased expression of KIR2DL5B mRNA |
CTD |
PMID:19774075 |
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KITLG |
KIT ligand |
increases expression |
EXP |
Amiodarone results in increased expression of KITLG mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851
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G |
KLF10 |
KLF transcription factor 10 |
increases expression |
EXP |
Amiodarone results in increased expression of KLF10 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
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G |
KLF15 |
KLF transcription factor 15 |
increases expression |
EXP |
Amiodarone results in increased expression of KLF15 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:126,288,125...126,357,408
Ensembl chr 3:126,342,635...126,357,408
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G |
KLF16 |
KLF transcription factor 16 |
increases expression |
EXP |
Amiodarone results in increased expression of KLF16 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:1,852,399...1,876,536
Ensembl chr19:1,852,399...1,863,579
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G |
KLF4 |
KLF transcription factor 4 |
increases expression |
EXP |
Amiodarone results in increased expression of KLF4 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
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KLHL28 |
kelch like family member 28 |
increases expression |
EXP |
Amiodarone results in increased expression of KLHL28 mRNA |
CTD |
PMID:19774075 |
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NCBI chr14:44,924,324...44,961,947
Ensembl chr14:44,924,324...45,042,322
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G |
KLK14 |
kallikrein related peptidase 14 |
increases expression |
EXP |
Amiodarone results in increased expression of KLK14 mRNA |
CTD |
PMID:19774075 |
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NCBI chr19:51,077,494...51,084,210
Ensembl chr19:51,077,495...51,084,245
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KRT17 |
keratin 17 |
increases expression |
EXP |
Amiodarone results in increased expression of KRT17 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:41,619,442...41,624,575
Ensembl chr17:41,619,442...41,624,842
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KRT23 |
keratin 23 |
increases expression |
ISO |
Amiodarone results in increased expression of KRT23 mRNA |
CTD |
PMID:24535564 |
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NCBI chr17:40,922,700...40,937,646
Ensembl chr17:40,922,700...40,937,646
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G |
KRT8 |
keratin 8 |
affects expression |
ISO |
Amiodarone affects the expression of KRT8 mRNA |
CTD |
PMID:19483382 |
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NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
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G |
L3MBTL1 |
L3MBTL histone methyl-lysine binding protein 1 |
increases expression |
EXP |
Amiodarone results in increased expression of L3MBTL1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr20:43,507,697...43,550,954
Ensembl chr20:43,489,442...43,550,954
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LACRT |
lacritin |
increases expression |
EXP |
Amiodarone results in increased expression of LACRT mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:54,630,811...54,634,895
Ensembl chr12:54,630,811...54,634,895
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LAMA2 |
laminin subunit alpha 2 |
increases expression |
ISO |
Amiodarone results in increased expression of LAMA2 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566
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G |
LARS2 |
leucyl-tRNA synthetase 2, mitochondrial |
increases expression |
ISO |
Amiodarone results in increased expression of LARS2 mRNA |
CTD |
PMID:24489787 |
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NCBI chr 3:45,388,576...45,549,407
Ensembl chr 3:45,388,561...45,554,726
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LCAT |
lecithin-cholesterol acyltransferase |
affects expression increases expression |
ISO |
Amiodarone affects the expression of LCAT mRNA Amiodarone results in increased expression of LCAT mRNA |
CTD |
PMID:19483382 PMID:22291062 |
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NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
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LCMT1 |
leucine carboxyl methyltransferase 1 |
affects expression |
ISO |
Amiodarone affects the expression of LCMT1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr16:25,111,742...25,178,228
Ensembl chr16:25,111,731...25,178,231
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LCTL |
lactase like |
increases expression |
EXP |
Amiodarone results in increased expression of LCTL mRNA |
CTD |
PMID:19774075 |
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NCBI chr15:66,547,532...66,565,998
Ensembl chr15:66,547,179...66,565,998
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G |
LDLR |
low density lipoprotein receptor |
multiple interactions decreases expression |
EXP ISO |
Amiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA] Amiodarone results in decreased expression of LDLR mRNA; Amiodarone results in decreased expression of LDLR protein Triiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein] |
CTD |
PMID:8137927 PMID:9071962 PMID:9712728 PMID:9751232 PMID:12538616 |
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NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820
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G |
LELP1 |
late cornified envelope like proline rich 1 |
increases expression |
EXP |
Amiodarone results in increased expression of LELP1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 1:153,203,430...153,205,120
Ensembl chr 1:153,203,430...153,205,120
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G |
LHCGR |
luteinizing hormone/choriogonadotropin receptor |
increases expression |
EXP |
Amiodarone results in increased expression of LHCGR mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730
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LIF |
LIF interleukin 6 family cytokine |
increases expression |
EXP |
Amiodarone results in increased expression of LIF mRNA |
CTD |
PMID:19774075 |
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NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759
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G |
LIMS3 |
LIM zinc finger domain containing 3 |
increases expression |
EXP |
Amiodarone results in increased expression of LIMS3 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 2:109,898,688...109,925,625
Ensembl chr 2:109,898,428...109,925,625
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LIN7A |
lin-7 homolog A, crumbs cell polarity complex component |
increases expression |
EXP |
Amiodarone results in increased expression of LIN7A mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:80,792,520...80,937,934
Ensembl chr12:80,792,520...80,937,934
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LINC00472 |
long intergenic non-protein coding RNA 472 |
increases expression |
EXP |
Amiodarone results in increased expression of LINC00472 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 6:71,407,864...71,420,745
Ensembl chr 6:71,187,161...71,420,745
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LINC01547 |
long intergenic non-protein coding RNA 1547 |
increases expression |
EXP |
Amiodarone results in increased expression of LINC01547 mRNA |
CTD |
PMID:19774075 |
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NCBI chr21:44,933,284...44,939,913
Ensembl chr21:44,932,814...44,939,951
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LIPC |
lipase C, hepatic type |
affects expression |
ISO |
Amiodarone affects the expression of LIPC mRNA |
CTD |
PMID:19483382 |
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NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844
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LIPE |
lipase E, hormone sensitive type |
multiple interactions increases phosphorylation |
ISO |
INS inhibits the reaction [Amiodarone results in increased phosphorylation of LIPE protein] |
CTD |
PMID:28962527 PMID:34259586 |
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NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,497...42,427,388
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LOX |
lysyl oxidase |
affects expression |
ISO |
Amiodarone affects the expression of LOX mRNA |
CTD |
PMID:18355885 PMID:19483382 |
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NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413
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G |
LPCAT3 |
lysophosphatidylcholine acyltransferase 3 |
increases expression |
ISO |
Amiodarone results in increased expression of LPCAT3 mRNA |
CTD |
PMID:24489787 |
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NCBI chr12:6,976,185...7,018,476
Ensembl chr12:6,976,185...7,018,477
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G |
LPGAT1 |
lysophosphatidylglycerol acyltransferase 1 |
increases expression |
ISO |
Amiodarone results in increased expression of LPGAT1 mRNA |
CTD |
PMID:22291062 |
|
NCBI chr 1:211,743,457...211,830,763
Ensembl chr 1:211,743,457...211,830,763
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G |
LPIN3 |
lipin 3 |
increases expression |
ISO |
Amiodarone results in increased expression of LPIN3 mRNA |
CTD |
PMID:24489787 |
|
NCBI chr20:41,340,821...41,360,582
Ensembl chr20:41,340,821...41,360,582
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G |
LRP3 |
LDL receptor related protein 3 |
affects expression |
ISO |
Amiodarone affects the expression of LRP3 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:33,194,330...33,208,864
Ensembl chr19:33,177,603...33,208,864
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LRP5 |
LDL receptor related protein 5 |
increases expression |
EXP |
Amiodarone results in increased expression of LRP5 mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:68,298,412...68,449,275
Ensembl chr11:68,312,591...68,449,275
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LSS |
lanosterol synthase |
increases expression affects expression |
ISO EXP |
Amiodarone results in increased expression of LSS mRNA Amiodarone affects the expression of LSS mRNA |
CTD |
PMID:15342952 PMID:17567588 PMID:19224547 PMID:22291062 PMID:24489787 PMID:29248575 More...
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NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
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LY6D |
lymphocyte antigen 6 family member D |
increases expression |
ISO |
Amiodarone results in increased expression of LY6D mRNA |
CTD |
PMID:24489787 |
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NCBI chr 8:142,784,882...142,786,539
Ensembl chr 8:142,784,882...142,786,539
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LYZ |
lysozyme |
increases expression |
EXP |
Amiodarone results in increased expression of LYZ mRNA |
CTD |
PMID:19774075 |
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NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234
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MACROD2 |
mono-ADP ribosylhydrolase 2 |
increases expression |
EXP |
Amiodarone results in increased expression of MACROD2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr20:13,995,516...16,053,197
Ensembl chr20:13,995,369...16,053,197
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MACROH2A1 |
macroH2A.1 histone |
affects expression |
ISO |
Amiodarone affects the expression of MACROH2A1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 5:135,334,381...135,399,887
Ensembl chr 5:135,334,381...135,399,914
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MAFF |
MAF bZIP transcription factor F |
increases expression |
EXP |
Amiodarone results in increased expression of MAFF mRNA |
CTD |
PMID:36586010 |
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NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
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MAFG |
MAF bZIP transcription factor G |
increases expression |
EXP |
Amiodarone results in increased expression of MAFG mRNA |
CTD |
PMID:19774075 PMID:36586010 |
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NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735
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MAGED4B |
MAGE family member D4B |
increases expression |
EXP |
Amiodarone results in increased expression of MAGED4B mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:52,061,827...52,069,272
Ensembl chr X:52,061,827...52,069,219
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MAN2B1 |
mannosidase alpha class 2B member 1 |
affects expression |
ISO |
Amiodarone affects the expression of MAN2B1 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:12,646,512...12,666,742
Ensembl chr19:12,643,831...12,666,742
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MANBA |
mannosidase beta |
affects expression |
ISO |
Amiodarone affects the expression of MANBA mRNA |
CTD |
PMID:18355885 |
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NCBI chr 4:102,630,770...102,760,968
Ensembl chr 4:102,630,770...102,760,994
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MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
increases lipidation multiple interactions |
EXP |
Amiodarone results in increased lipidation of MAP1LC3B protein Amiodarone results in increased expression of and results in increased lipidation of MAP1LC3B protein; Amiodarone results in increased lipidation of and results in increased localization of MAP1LC3B protein |
CTD |
PMID:25881747 PMID:32651653 PMID:37661063 |
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NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
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MAP2K1 |
mitogen-activated protein kinase kinase 1 |
multiple interactions |
ISO |
MAP2K1 protein inhibits the reaction [Amiodarone results in decreased expression of SNAI1 protein] |
CTD |
PMID:26515726 |
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NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
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MAP2K2 |
mitogen-activated protein kinase kinase 2 |
affects expression |
ISO |
Amiodarone affects the expression of MAP2K2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122
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MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation decreases phosphorylation multiple interactions |
ISO EXP |
Amiodarone results in increased phosphorylation of MAPK1 protein Amiodarone results in decreased phosphorylation of MAPK1 protein [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Vitamin D inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:26515726 PMID:31071512 PMID:34590760 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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MAPK14 |
mitogen-activated protein kinase 14 |
increases phosphorylation multiple interactions |
ISO |
Amiodarone results in increased phosphorylation of MAPK14 protein [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Vitamin D inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:34590760 |
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NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511
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MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation decreases phosphorylation multiple interactions |
ISO EXP |
Amiodarone results in increased phosphorylation of MAPK3 protein Amiodarone results in decreased phosphorylation of MAPK3 protein [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]; Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]; Vitamin D inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:26515726 PMID:31071512 PMID:34590760 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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MAPK8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO EXP |
Amiodarone results in increased phosphorylation of MAPK8 protein Amiodarone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:25073960 PMID:34259586 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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MASP1 |
MBL associated serine protease 1 |
increases expression |
EXP |
Amiodarone results in increased expression of MASP1 mRNA |
CTD |
PMID:19774075 |
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NCBI chr 3:187,217,282...187,291,737
Ensembl chr 3:187,217,282...187,291,980
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MASP2 |
MBL associated serine protease 2 |
affects expression |
ISO |
Amiodarone affects the expression of MASP2 mRNA |
CTD |
PMID:19483382 |
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NCBI chr 1:11,026,523...11,047,239
Ensembl chr 1:11,022,009...11,047,239
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MBP |
myelin basic protein |
affects expression |
ISO |
Amiodarone affects the expression of MBP mRNA |
CTD |
PMID:25659768 |
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NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
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MCAM |
melanoma cell adhesion molecule |
increases expression |
EXP |
Amiodarone results in increased expression of MCAM mRNA |
CTD |
PMID:19774075 |
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NCBI chr11:119,308,529...119,317,130
Ensembl chr11:119,308,529...119,321,521
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MCF2 |
MCF.2 cell line derived transforming sequence |
increases expression |
EXP |
Amiodarone results in increased expression of MCF2 mRNA |
CTD |
PMID:19774075 |
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NCBI chr X:139,581,770...139,708,167
Ensembl chr X:139,581,770...139,708,216
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ME1 |
malic enzyme 1 |
increases expression affects expression |
ISO |
Amiodarone results in increased expression of ME1 protein Amiodarone affects the expression of ME1 mRNA |
CTD |
PMID:16538043 PMID:19483382 |
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NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051
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MED11 |
mediator complex subunit 11 |
increases expression |
EXP |
Amiodarone results in increased expression of MED11 mRNA |
CTD |
PMID:19774075 |
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NCBI chr17:4,731,428...4,733,607
Ensembl chr17:4,731,428...4,733,608
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MEF2C |
myocyte enhancer factor 2C |
increases expression |
EXP |
Amiodarone results in increased expression of MEF2C mRNA |
CTD |
PMID:19774075 |
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NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257
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MFHAS1 |
multif | |