Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sapogenin
go back to main search page
Accession:CHEBI:26606 term browser browse the term
Definition:Any organic polycyclic compound that is the aglycon moiety of a saponin; sapogenins may be steroids or triterpenoids.
Synonyms:related_synonym: sapogenins


show annotations for term's descendants           Sort by:
(20R)-protopanaxadiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:29133030 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Bcl2l1 BCL2-like 1 increases expression ISO protopanaxadiol results in increased expression of BCL2L1 mRNA CTD PMID:31805304 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression ISO protopanaxadiol affects the expression of BIRC5 protein CTD PMID:31805304 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Casp3 caspase 3 increases expression
affects cleavage		 ISO protopanaxadiol results in increased expression of CASP3 mRNA
protopanaxadiol affects the cleavage of CASP3 protein		 CTD PMID:31805304 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases expression
affects expression		 ISO protopanaxadiol results in increased expression of CASP9 mRNA
protopanaxadiol affects the expression of CASP9 protein		 CTD PMID:31805304 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO protopanaxadiol results in increased expression of CCNA2 mRNA CTD PMID:31805304 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO protopanaxadiol results in increased expression of CCNB1 mRNA CTD PMID:31805304 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO protopanaxadiol results in increased expression of CCND1 mRNA CTD PMID:31805304 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
increases expression		 ISO protopanaxadiol results in increased expression of and results in decreased phosphorylation of CDC25A protein
protopanaxadiol results in increased expression of CDC25A mRNA		 CTD PMID:31805304 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963 		JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions		 ISO protopanaxadiol results in increased expression of CDC25C mRNA
protopanaxadiol affects the expression of and affects the phosphorylation of CDC25C protein		 CTD PMID:31805304 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression ISO protopanaxadiol results in increased expression of CDK1 mRNA CTD PMID:31805304 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO protopanaxadiol results in increased expression of CDK2 mRNA CTD PMID:31805304 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 increases expression ISO protopanaxadiol results in increased expression of CDK4 mRNA; protopanaxadiol results in increased expression of CDK4 protein CTD PMID:31805304 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:29133030 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases activity		 ISO protopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR protein
protopanaxadiol results in decreased activity of EGFR protein		 CTD PMID:31805304 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] CTD PMID:29133030 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein] CTD PMID:29133030 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein] CTD PMID:29133030 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases expression ISO protopanaxadiol results in increased expression of MAP2K1 mRNA CTD PMID:31805304 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK1 protein CTD PMID:31805304 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK3 protein CTD PMID:31805304 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression ISO protopanaxadiol results in increased expression of PARP1 mRNA CTD PMID:31805304 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 increases phosphorylation ISO protopanaxadiol results in increased phosphorylation of RAF1 protein CTD PMID:31805304 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase polypeptide 1 increases expression ISO protopanaxadiol results in increased expression of RPS6KA1 mRNA CTD PMID:31805304 NCBI chr 4:133,574,601...133,615,466
Ensembl chr 4:133,574,601...133,615,108 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO protopanaxadiol affects the expression of STAT3 protein CTD PMID:31805304 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO protopanaxadiol results in increased expression of TP53 mRNA; protopanaxadiol results in increased expression of TP53 protein CTD PMID:31805304 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
(20S)-ginsenoside Rg3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
decreases expression		 ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA] CTD PMID:31916386 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein] CTD PMID:27387537 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007 		JBrowse link
G Ar androgen receptor increases degradation
multiple interactions		 ISO ginsenoside Rg3 results in increased degradation of AR protein
ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein]		 CTD PMID:22101440 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Areg amphiregulin decreases expression ISO ginsenoside Rg3 results in decreased expression of AREG mRNA CTD PMID:31916386 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of BAX protein] CTD PMID:26427350 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of BCL2 protein] CTD PMID:26427350 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO
EXP		 [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP
ISO		 ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]		 CTD PMID:34423507 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein] CTD PMID:27387537 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ginsenoside Rg3 results in decreased expression of BIRC5 mRNA; ginsenoside Rg3 results in decreased expression of BIRC5 protein CTD PMID:19778801 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]] CTD PMID:27387537 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]] CTD PMID:27387537 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein] CTD PMID:34423507 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO ginsenoside Rg3 results in increased cleavage of CASP3 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP3 protein]		 CTD PMID:22101440 PMID:26427350 PMID:31916386 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein] CTD PMID:26427350 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP9 protein] CTD PMID:26427350 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO ginsenoside Rg3 inhibits the reaction [dimethoxon results in decreased activity of CAT protein] CTD PMID:26240163 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of CCN1 mRNA CTD PMID:31916386 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of CCN2 mRNA CTD PMID:31916386 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:24793912 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions EXP [Xiao-Ke-An results in increased abundance of ginsenoside Rg3] which results in decreased activity of DPP4 protein CTD PMID:32535096 NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]] CTD PMID:25824408 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
affects phosphorylation		 ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]; ginsenoside Rg3 results in decreased expression of and affects the localization of EGFR protein CTD PMID:25824408 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO ginsenoside Rg3 results in decreased expression of EPCAM mRNA CTD PMID:31916386 NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557 		JBrowse link
G Fut4 fucosyltransferase 4 multiple interactions
decreases expression		 ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of FUT4 protein]
ginsenoside Rg3 results in decreased expression of FUT4 protein		 CTD PMID:26427350 NCBI chr 9:14,659,755...14,663,418
Ensembl chr 9:14,659,616...14,663,689 		JBrowse link
G Hsf1 heat shock factor 1 multiple interactions
decreases expression		 ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]
ginsenoside Rg3 results in decreased expression of HSF1 protein		 CTD PMID:26427350 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO
EXP		 ginsenoside Rg3 results in increased expression of IL1B protein
ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]		 CTD PMID:14534150 PMID:33050067 PMID:34423507 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO ginsenoside Rg3 results in decreased expression of KIT mRNA CTD PMID:31916386 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382 		JBrowse link
G Klf4 Kruppel-like transcription factor 4 (gut) decreases expression ISO ginsenoside Rg3 results in decreased expression of KLF4 mRNA CTD PMID:31916386 NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466 		JBrowse link
G Lats1 large tumor suppressor increases expression ISO ginsenoside Rg3 results in increased expression of LATS1 mRNA CTD PMID:31916386 NCBI chr10:7,556,964...7,592,225
Ensembl chr10:7,556,978...7,592,224 		JBrowse link
G Lats2 large tumor suppressor 2 increases expression ISO ginsenoside Rg3 results in increased expression of LATS2 mRNA CTD PMID:31916386 NCBI chr14:57,927,119...57,983,669
Ensembl chr14:57,927,119...57,995,845
Ensembl chr14:57,927,119...57,995,845 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP ginsenoside Rg3 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO [ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein CTD PMID:31916386 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] CTD PMID:24793912 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased activity of MPO protein] CTD PMID:26240163 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO ginsenoside Rg3 results in decreased expression of MYC mRNA CTD PMID:31916386 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO ginsenoside Rg3 results in decreased expression of NANOG mRNA CTD PMID:31916386 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
increases activity		 ISO [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein
ginsenoside Rg3 results in increased activity of NFKB1 protein		 CTD PMID:14534150 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein; [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein CTD PMID:14534150 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:34423507 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression		 ISO Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]
ginsenoside Rg3 results in increased expression of NOS2 mRNA		 CTD PMID:14534150 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions ISO
EXP		 [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]		 CTD PMID:24394491 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions		 ISO ginsenoside Rg3 results in increased cleavage of PARP1 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of PARP1 protein]		 CTD PMID:22101440 PMID:24793912 PMID:26427350 PMID:31916386 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic increases expression ISO ginsenoside Rg3 results in increased expression of PCK1 mRNA CTD PMID:30144466 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of POU5F1 mRNA CTD PMID:31916386 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO ginsenoside Rg3 results in increased expression of PPARGC1A mRNA CTD PMID:30144466 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions		 ISO ginsenoside Rg3 results in decreased expression of PROM1 mRNA
XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]		 CTD PMID:31916386 NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO		 ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]		 CTD PMID:34423507 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP		 [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; ginsenoside Rg3 affects the localization of and results in increased activity of RELA protein
ginsenoside Rg3 results in decreased expression of and results in decreased phosphorylation of RELA protein		 CTD PMID:14534150 PMID:33050067 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]] CTD PMID:27387537 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Sall4 spalt like transcription factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of SALL4 mRNA CTD PMID:31916386 NCBI chr 2:168,590,252...168,609,121
Ensembl chr 2:168,590,252...168,609,863 		JBrowse link
G Sirt1 sirtuin 1 increases activity ISO ginsenoside Rg3 results in increased activity of SIRT1 protein CTD PMID:30144466 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 multiple interactions EXP [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A2 protein] CTD PMID:24394491 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions EXP [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein] CTD PMID:24394491 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:24793912 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of SOX2 mRNA CTD PMID:31916386 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein] CTD PMID:26427350 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO
EXP		 3-methyladenine affects the reaction [ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]]; ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]
ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein]		 CTD PMID:34423507 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Stk3 serine/threonine kinase 3 increases expression ISO ginsenoside Rg3 results in increased expression of STK3 mRNA CTD PMID:31916386 NCBI chr15:34,875,645...35,155,990
Ensembl chr15:34,875,642...35,179,067 		JBrowse link
G Stk4 serine/threonine kinase 4 increases expression ISO ginsenoside Rg3 results in increased expression of STK4 mRNA CTD PMID:31916386 NCBI chr 2:163,916,033...163,997,444
Ensembl chr 2:163,912,242...163,997,444 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thy1 thymus cell antigen 1, theta decreases expression ISO ginsenoside Rg3 results in decreased expression of THY1 mRNA CTD PMID:31916386 NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 ginsenoside Rg3 results in increased expression of TNF protein
ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased expression of TNF protein]
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; ginsenoside Rg3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]		 CTD PMID:14534150 PMID:26240163 PMID:33050067 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]] CTD PMID:27387537 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Vim vimentin multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:24793912 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of WWTR1 mRNA CTD PMID:31916386 NCBI chr 3:57,363,065...57,483,331
Ensembl chr 3:57,363,070...57,483,331 		JBrowse link
G Yap1 yes-associated protein 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of YAP1 mRNA CTD PMID:31916386 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597 		JBrowse link
(20S)-ginsenoside Rh1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos FBJ osteosarcoma oncogene increases expression ISO ginsenoside Rh1 results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA] CTD PMID:16557482 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 decreases expression EXP ginsenoside Rh1 results in decreased expression of IL4 CTD PMID:22855946 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga4 integrin alpha 4 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467 		JBrowse link
G Itgal integrin alpha L multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310 		JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Jun jun proto-oncogene decreases activity EXP ginsenoside Rh1 results in decreased activity of JUN protein CTD PMID:22855946 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Lpl lipoprotein lipase increases secretion EXP ginsenoside Rh1 results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rh1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein] CTD PMID:32623698 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] CTD PMID:16557482 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Rh1 results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
decreases expression		 ISO
EXP		 ginsenoside Rh1 results in decreased susceptibility to TNF protein
ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 results in decreased expression of TNF		 CTD PMID:16557482 PMID:21875580 PMID:22855946 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of AKT1 protein CTD PMID:32762018 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 PMID:32762018 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 PMID:32762018 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases expression		 ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein
ginsenoside Rh2 results in decreased expression of CASP3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 decreases expression ISO ginsenoside Rh2 results in decreased expression of CASP9 protein CTD PMID:32762018 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK1 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
increases phosphorylation		 ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK3 protein		 CTD PMID:26482938 PMID:32762018 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MTOR protein CTD PMID:32762018 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases expression ISO ginsenoside Rh2 results in increased expression of NFKBIA protein CTD PMID:32762018 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO ginsenoside Rh2 results in increased expression of and results in decreased phosphorylation of RELA protein CTD PMID:32762018 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
16alpha,17beta-Estriol 17-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
Aescin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions
increases expression		 EXP
ISO		 ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]; Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]
Escin results in increased expression of ACACA mRNA
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of ACACA mRNA]		 CTD PMID:36905866 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO
EXP		 Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of ACOX1 mRNA]
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]		 CTD PMID:36905866 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 EXP
ISO		 ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]; ATG5 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG5 protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of ATG5 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG5 protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of ATG5 protein]
Escin results in increased expression of ATG5 protein		 CTD PMID:36905866 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atg7 autophagy related 7 multiple interactions EXP
ISO		 Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG7 protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG7 protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of ATG7 protein]		 CTD PMID:36905866 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression		 EXP
ISO		 Escin inhibits the reaction [Dietary Fats results in decreased expression of BECN1 protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of BECN1 protein]]
Escin results in increased expression of BECN1 protein		 CTD PMID:36905866 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression
multiple interactions		 ISO
EXP		 Escin results in increased expression of CPT1A mRNA
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]		 CTD PMID:36905866 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP
ISO		 ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of CPT2 mRNA]		 CTD PMID:36905866 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression 		ISO Aescin increased activity of cyp1a2 protein enzyme in rat plasma
Aescin increased expression of Cyp1a2 mRNA in rat liver		 RGD PMID:24252494 PMID:24252494 RGD:401900603, RGD:401900603 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression		 EXP ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]; Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]
Escin results in decreased expression of FAS mRNA		 CTD PMID:36905866 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 EXP
ISO		 Escin results in increased expression of GCLC protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein]
Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein]]		 CTD PMID:36905866 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
increases expression		 EXP
ISO		 Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLM protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLM protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLM protein]
Escin results in increased expression of GCLM protein		 CTD PMID:36905866 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]; Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; Escin inhibits the reaction [tyloxapol results in increased expression of GPT protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]] CTD PMID:36905866 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 Escin results in increased expression of HMOX1 protein
Escin inhibits the reaction [Dietary Fats results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of HMOX1 protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of HMOX1 protein]		 CTD PMID:36905866 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions
increases expression		 EXP
ISO		 Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]; Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]]
Escin results in increased expression of KEAP1 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein]		 CTD PMID:36905866 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 EXP
ISO		 ATG5 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]; Escin inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]; Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]; NFE2L2 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]
Escin results in increased lipidation of MAP1LC3B protein		 CTD PMID:36905866 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Myl9 myosin, light polypeptide 9, regulatory multiple interactions ISO [Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein; [Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein]; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein] CTD PMID:29660437 NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions		 EXP
ISO		 Escin results in increased expression of NFE2L2 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of NFE2L2 protein]; Escin results in increased expression of and affects the localization of NFE2L2 protein
Escin inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG5 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG7 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of BECN1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLM protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]; NFE2L2 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]		 CTD PMID:36905866 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions		 ISO
EXP		 Escin results in increased expression of NQO1 protein
Escin inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of NQO1 protein]		 CTD PMID:36905866 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of PPARA protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]] CTD PMID:36905866 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 ISO Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of PPARG protein]
Escin results in increased expression of PPARG protein		 CTD PMID:36905866 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein] CTD PMID:29660437 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP
ISO		 ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]; Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]; Escin inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SQSTM1 protein]		 CTD PMID:36905866 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 EXP
ISO		 Escin results in increased expression of SREBF1 mRNA; Escin results in increased expression of SREBF1 protein
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]; Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]; Escin inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SREBF1 mRNA]; Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SREBF1 protein]		 CTD PMID:36905866 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
alpha-Chaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions EXP alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:25913072 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:25913072 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and affects the localization of JUN protein]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of JUN protein modified form] CTD PMID:25913072 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP2K7 protein] CTD PMID:25913072 NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein] CTD PMID:25913072 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] CTD PMID:25913072 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK9 protein] CTD PMID:25913072 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:25913072 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:25913072 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:25913072 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
alpha-Solamarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD protein] CTD PMID:35350913 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 protein] CTD PMID:35350913 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BDNF protein] CTD PMID:35350913 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of CASP3 mRNA] CTD PMID:35350913 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of CREB1 protein] CTD PMID:35350913 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein] CTD PMID:35350913 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of FOXO3 protein] CTD PMID:35350913 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLM mRNA] CTD PMID:35350913 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA] CTD PMID:35350913 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein] CTD PMID:35350913 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of IL1B mRNA] CTD PMID:35350913 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 protein] CTD PMID:35350913 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein] CTD PMID:35350913 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Prrx1 paired related homeobox 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of PRRX1 protein] CTD PMID:35350913 NCBI chr 1:163,072,688...163,142,714
Ensembl chr 1:163,072,688...163,141,279 		JBrowse link
G Sypl1 synaptophysin like 1 multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL1 protein] CTD PMID:35350913 NCBI chr12:33,003,874...33,029,503
Ensembl chr12:33,003,890...33,029,859 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of TNF mRNA] CTD PMID:35350913 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Anemoside B4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:32991863 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:32991863 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BECN1 protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BECN1 protein] CTD PMID:34051206 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:32991863 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:32991863 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions EXP 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein] CTD PMID:34051206 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO anemoside B4 results in decreased secretion of CCL2 protein CTD PMID:36084722 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of CHUK protein] CTD PMID:32991863 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of IKBKB protein] CTD PMID:32991863 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; anemoside B4 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:32991863 PMID:34051206 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:34051206 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 decreases phosphorylation ISO anemoside B4 results in decreased phosphorylation of ITPR1 protein CTD PMID:36084722 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:32991863 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:32991863 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein] CTD PMID:32991863 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] CTD PMID:32991863 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:32991863 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Plcg1 phospholipase C, gamma 1 decreases phosphorylation ISO anemoside B4 results in decreased phosphorylation of PLCG1 protein CTD PMID:36084722 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] CTD PMID:32991863 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:32991863 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein] CTD PMID:34051206 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO anemoside B4 results in decreased phosphorylation of STAT3 protein CTD PMID:36084722 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion		 EXP
ISO		 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; anemoside B4 inhibits the reaction [Cisplatin results in increased expression of TNF protein]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
anemoside B4 results in decreased secretion of TNF protein		 CTD PMID:32991863 PMID:34051206 PMID:36084722 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Asiaticoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor increases expression
multiple interactions		 ISO asiaticoside results in increased expression of BDNF mRNA
asiaticoside inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]		 CTD PMID:28238857 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Cat catalase multiple interactions ISO asiaticoside inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:28238857 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO asiaticoside results in decreased activity of CYP2C19 protein CTD PMID:21349323 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO asiaticoside inhibits the reaction [Rotenone results in decreased expression of MAPK14 protein] CTD PMID:28238857 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [asiaticoside co-treated with Rotenone] results in decreased expression of MTOR protein CTD PMID:28238857 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions		 ISO asiaticoside results in increased expression of NGF protein
asiaticoside inhibits the reaction [Rotenone results in decreased expression of NGF protein]		 CTD PMID:28238857 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 multiple interactions ISO asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 mRNA]; asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 protein] CTD PMID:28238857 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions ISO asiaticoside inhibits the reaction [Rotenone results in increased expression of PEBP1 mRNA] CTD PMID:28238857 NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 multiple interactions ISO asiaticoside inhibits the reaction [Rotenone results in decreased expression of PIK3R6 mRNA] CTD PMID:28238857 NCBI chr11:68,393,845...68,443,524
Ensembl chr11:68,393,845...68,443,524 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions ISO asiaticoside inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28238857 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Stx1a syntaxin 1A (brain) multiple interactions ISO [Rotenone co-treated with asiaticoside] results in decreased expression of STX1A mRNA CTD PMID:28238857 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954 		JBrowse link
G Synj1 synaptojanin 1 multiple interactions ISO [asiaticoside co-treated with Rotenone] results in decreased expression of SYNJ1 mRNA CTD PMID:28238857 NCBI chr16:90,732,980...90,810,543
Ensembl chr16:90,732,980...90,808,196 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [asiaticoside co-treated with Rotenone] results in decreased expression of TH protein CTD PMID:28238857 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
astragaloside IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32344236 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aqp9 aquaporin 9 increases expression EXP astragaloside A results in increased expression of AQP9 mRNA; astragaloside A results in increased expression of AQP9 protein CTD PMID:37918281 NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 multiple interactions ISO astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA] CTD PMID:17509559 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein] CTD PMID:22278385 PMID:33285147 PMID:36322813 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein] CTD PMID:33285147 PMID:36322813 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCS1L protein] CTD PMID:22278385 NCBI chr 1:74,627,448...74,631,602
Ensembl chr 1:74,627,448...74,631,602 		JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CASP3 protein modified form]
astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]		 CTD PMID:22278385 PMID:30842369 PMID:33285147 PMID:36322813 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP astragaloside A results in increased expression of CCND1 protein CTD PMID:37918281 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression
multiple interactions		 EXP
ISO		 astragaloside IV decreases expression Dusp5 mRNA and protein in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate increases expression of DUSP5 mRNA and protein in Vascular smooth muscle cells]		 RGD PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA CTD PMID:32344236 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] CTD PMID:33285147 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Gja4 gap junction protein, alpha 4 multiple interactions ISO astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of GJA4 protein] CTD PMID:36322813 NCBI chr 4:127,205,213...127,207,832
Ensembl chr 4:127,205,214...127,207,832 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO astragaloside A inhibits the reaction [bisphenol A results in decreased activity of GLUL protein] CTD PMID:34434659 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein] CTD PMID:30842369 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) multiple interactions ISO astragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2A mRNA] CTD PMID:34434659 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions ISO astragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2B mRNA] CTD PMID:34434659 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G H19 H19, imprinted maternally expressed transcript increases expression
multiple interactions		 EXP
ISO		 astragaloside IV increases expression H19 RNA in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate decreases expression of H19 RNA in Vascular smooth muscle cells]		 RGD PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,133,957 		JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HDAC9 protein] CTD PMID:36322813 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
astragaloside A results in increased expression of HMOX1 mRNA; astragaloside A results in increased expression of HMOX1 protein		 CTD PMID:25422538 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; astragaloside A inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein] CTD PMID:25604657 PMID:30842369 PMID:32344236 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]		 CTD PMID:25604657 PMID:32344236 PMID:33285147 PMID:36322813 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 decreases expression
multiple interactions		 EXP
ISO		 astragaloside IV decreases expression of Khdrbs1 protein in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate astragaloside IV increases expression of KHDRBS1 protein in Vascular smooth muscle cells]		 RGD PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 4:129,596,143...129,637,402
Ensembl chr 4:129,596,957...129,636,096 		JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO astragaloside A inhibits the reaction [bisphenol A results in increased expression of MAOA protein] CTD PMID:33666843 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] CTD PMID:33285147 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] CTD PMID:33285147 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein CTD PMID:32344236 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO astragaloside A inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein] CTD PMID:25604657 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation		 ISO
EXP		 [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA
astragaloside IV inhibits the reaction [beta-Glycerophosphate decreases phoshorylation of MTOR protein in Vascular smooth muscle cells]
astragaloside IV increases phosphorylation Mtor protein in thoracic aorta		 CTD
RGD		 PMID:32344236 PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein CTD PMID:32344236 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Muc5b mucin 5, subtype B, tracheobronchial multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA CTD PMID:32344236 NCBI chr 7:141,392,796...141,426,826
Ensembl chr 7:141,392,807...141,426,821 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects localization		 EXP [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
astragaloside A affects the localization of NFE2L2 protein		 CTD PMID:25422538 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]		 CTD PMID:25604657 PMID:33285147 PMID:36322813 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta multiple interactions ISO astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein] CTD PMID:25604657 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:30842369 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP astragaloside A results in increased expression of PCNA protein CTD PMID:37918281 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pln phospholamban multiple interactions ISO astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:17509559 NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression ISO Astragaloside IV increases expression of Ptpn1 protein in the hypothalamus RGD PMID:29562733 RGD:401976390 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO astragaloside A inhibits the reaction [Taurocholic Acid affects the localization of RELA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]		 CTD PMID:25604657 PMID:33285147 PMID:36322813 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rho rhodopsin multiple interactions EXP astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 6:115,903,741...115,916,999
Ensembl chr 6:115,908,709...115,916,997 		JBrowse link
G Rpe65 retinal pigment epithelium 65 multiple interactions EXP astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 3:159,304,712...159,330,944
Ensembl chr 3:159,304,812...159,330,958 		JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 protein] CTD PMID:25604657 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO astragaloside A promotes the reaction [Taurocholic Acid results in decreased expression of SOD2 protein]; astragaloside A promotes the reaction [Taurocholic Acid results in increased expression of SOD2 mRNA] CTD PMID:25604657 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO astragaloside A inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein] CTD PMID:30842369 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein CTD PMID:32344236 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]		 CTD PMID:25604657 PMID:32344236 PMID:33285147 PMID:36322813 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions ISO astragaloside A affects the reaction [bisphenol A affects the expression of TPH2 mRNA] CTD PMID:33666843 NCBI chr10:114,914,546...115,020,927
Ensembl chr10:114,914,546...115,020,927 		JBrowse link
Bacoside a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein] CTD PMID:27899289 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein] CTD PMID:27899289 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Cat catalase increases activity
multiple interactions		 ISO bacoside A results in increased activity of CAT protein
bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]		 CTD PMID:16226278 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CP protein] CTD PMID:16226278 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA] CTD PMID:20821261 NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions ISO bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA] CTD PMID:20821261 NCBI chr 7:57,057,417...57,240,808
Ensembl chr 7:57,057,420...57,159,807 		JBrowse link
G Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta multiple interactions ISO bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA] CTD PMID:20821261 NCBI chr 4:155,469,437...155,482,528
Ensembl chr 4:155,469,437...155,482,569 		JBrowse link
G Gsr glutathione reductase increases activity
multiple interactions		 ISO bacoside A results in increased activity of GSR protein
bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of GSR protein]		 CTD PMID:16226278 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO bacoside A inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased activity of MMP2 protein] CTD PMID:20084675 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO bacoside A inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:20084675 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
Beta-Solamarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO beta-solamarine results in increased expression of BAX protein
beta-solamarine promotes the reaction [Cisplatin results in increased expression of BAX protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO beta-solamarine results in decreased expression of BCL2 protein CTD PMID:17619073 PMID:20647040 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO beta-solamarine results in decreased expression of BCL2L1 protein CTD PMID:17619073 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions		 ISO beta-solamarine results in increased cleavage of CASP3 protein
beta-solamarine results in increased activity of CASP3 protein
beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP3 protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein]
beta-solamarine results in increased activity of CASP8 protein		 CTD PMID:17619073 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions		 ISO beta-solamarine results in increased activity of CASP9 protein
beta-solamarine results in increased cleavage of CASP9 protein
beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP9 protein]		 CTD PMID:17619073 PMID:20647040 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ctsb cathepsin B affects localization ISO beta-solamarine affects the localization of CTSB protein CTD PMID:20647040 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO beta-solamarine results in increased expression of FADD protein CTD PMID:17619073 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO beta-solamarine results in increased expression of FAS protein CTD PMID:17619073 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a increases expression ISO beta-solamarine results in increased expression of TNFRSF1A protein CTD PMID:17619073 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO beta-solamarine results in increased expression of TRADD protein CTD PMID:17619073 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241 		JBrowse link
Chikusetsusaponin-IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO araloside A results in decreased expression of BCL2 protein CTD PMID:31004595 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Il1b interleukin 1 beta decreases expression
decreases secretion		 ISO araloside A results in decreased expression of IL1B mRNA
araloside A results in decreased secretion of IL1B protein		 CTD PMID:31004595 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 decreases secretion
decreases expression		 ISO araloside A results in decreased secretion of IL6 protein
araloside A results in decreased expression of IL6 mRNA		 CTD PMID:31004595 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation ISO araloside A results in decreased phosphorylation of NFKBIA protein CTD PMID:31004595 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases phosphorylation ISO araloside A results in decreased phosphorylation of RELA protein CTD PMID:31004595 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
Chikusetsusaponin-V term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:25073091 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:25073091 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP12 mRNA] CTD PMID:25073091 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions EXP [Xiao-Ke-An results in increased abundance of ginsenoside Ro] which results in decreased activity of DPP4 protein CTD PMID:32535096 NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP ginsenoside Ro results in increased phosphorylation of GSK3B protein CTD PMID:32535096 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein] CTD PMID:25073091 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Lpl lipoprotein lipase increases secretion EXP ginsenoside Ro results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] CTD PMID:25073091 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 mRNA] CTD PMID:25073091 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
cycloastragenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 increases expression EXP cycloastragenol results in increased expression of AQP9 mRNA; cycloastragenol results in increased expression of AQP9 protein CTD PMID:37918281 NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964 		JBrowse link
G Arhgap17 Rho GTPase activating protein 17 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Arhgap17 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 7:122,878,372...122,969,171
Ensembl chr 7:122,878,441...122,969,138 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Bax protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP cycloastragenol results in increased expression of CCND1 protein CTD PMID:37918281 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions EXP cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of CXCL15 protein] CTD PMID:37579952 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Dsc2 desmocollin 2 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Dsc2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:20,163,690...20,192,611
Ensembl chr18:20,163,690...20,192,611 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Gsk3b protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Ifng interferon gamma multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Ifng protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Ikbkg protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il10 protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il17 protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il1b protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Il4 protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il6 protein in spleenocytes and peripheral blood]
cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of IL6 protein]		 CTD
RGD		 PMID:37579952 PMID:32068187 RGD:267358468 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of MMP9 protein] CTD PMID:37579952 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Mt-co2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP cycloastragenol results in increased expression of PCNA protein CTD PMID:37918281 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Plcg1 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Rhoa protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rit2 Ras-like without CAAX 2 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Rit2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:31,107,367...31,450,181
Ensembl chr18:31,106,542...31,450,343 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TERT protein]; cycloastragenol inhibits the reaction [Benzo(a)pyrene results in decreased expression of TERT protein] CTD PMID:37579952 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Tnf protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Zeb1 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467 		JBrowse link
digitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 increases expression EXP Digitonin results in increased expression of CCNB1 protein CTD PMID:36030841 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Digitonin results in increased expression of CCND1 protein CTD PMID:36030841 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] CTD PMID:31404653 NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A decreases expression EXP Digitonin results in decreased expression of CDKN1A protein CTD PMID:36030841 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B decreases expression EXP Digitonin results in decreased expression of CDKN1B protein CTD PMID:36030841 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression EXP Digitonin results in increased expression of CYP2B10 protein CTD PMID:36030841 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression EXP Digitonin results in increased expression of CYP3A11 protein CTD PMID:36030841 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Etv2 ets variant 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 7:30,333,041...30,335,934
Ensembl chr 7:30,333,041...30,335,277 		JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Hexb hexosaminidase B multiple interactions
increases activity		 EXP 1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [Digitonin results in increased activity of HEXB protein] CTD PMID:36860548 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit decreases expression ISO Digitonin results in decreased expression of HIF1A protein CTD PMID:34717917 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 increases expression EXP Digitonin results in increased expression of NEK2 protein CTD PMID:36030841 NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression EXP Digitonin results in decreased expression of RBL2 protein CTD PMID:36030841 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Digitonin results in increased expression of SLCO1A4 protein CTD PMID:36030841 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Spn sialophorin multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995 		JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8b ATP-binding cassette, sub-family A member 8b multiple interactions ISO Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr11:109,823,016...109,886,642
Ensembl chr11:109,823,016...109,886,671 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases uptake
affects uptake
increases uptake
multiple interactions
increases export
increases transport
affects secretion
affects binding
affects abundance
increases expression
affects transport		 ISO
EXP		 ABCB1 protein results in decreased uptake of Digoxin
ABCB1A protein affects the uptake of Digoxin
ABCB1 protein results in increased uptake of Digoxin
18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Plant Extracts results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; ABCB1 protein binds to and affects the metabolism of Digoxin; abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; cyazofamid affects the reaction [ABCB1 protein results in increased uptake of Digoxin]; dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]; gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Digoxin; Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin]
ABCB1A protein results in increased uptake of Digoxin
ABCB1 protein affects the secretion of Digoxin
Digoxin binds to ABCB1 protein
ABCB1 gene SNP affects the abundance of Digoxin
Digoxin results in increased expression of ABCB1 mRNA; Digoxin results in increased expression of ABCB1 protein
ABCB1 gene SNP affects the transport of Digoxin; ABCB1 protein affects the transport of Digoxin		 CTD PMID:10527640 PMID:10562306 PMID:10617675 PMID:10997946 PMID:11231118 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects uptake EXP ABCB1B protein affects the uptake of Digoxin CTD PMID:10562306 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases activity ISO Digoxin results in decreased activity of ABCG2 protein CTD PMID:15365089 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of ALPL protein] CTD PMID:36329302 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide decreases expression
multiple interactions		 ISO Digoxin results in decreased expression of ATP1A2 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]		 CTD PMID:19687166 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide decreases expression
multiple interactions		 ISO Digoxin results in decreased expression of ATP1A3 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A3 mRNA]		 CTD PMID:19687166 NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digoxin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digoxin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Digoxin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 protein] CTD PMID:36329302 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases expression
increases expression		 ISO Digoxin results in decreased expression of CXCL8 protein
Digoxin results in increased expression of CXCL8 mRNA		 CTD PMID:20116850 PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 protein] CTD PMID:36329302 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein] CTD PMID:36329302 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 protein] CTD PMID:36329302 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Fancd2 Fanconi anemia, complementation group D2 multiple interactions ISO Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 6:113,508,622...113,573,981
Ensembl chr 6:113,508,643...113,573,978 		JBrowse link
G Fanci Fanconi anemia, complementation group I multiple interactions ISO Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 7:79,042,056...79,100,013
Ensembl chr 7:79,041,677...79,100,012 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases activity ISO Digoxin results in decreased activity of G6PD protein CTD PMID:26820767 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Digoxin results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein] CTD PMID:36329302 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GPT protein] CTD PMID:36329302 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase decreases activity ISO Digoxin results in decreased activity of GSR protein CTD PMID:26820767 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
increases activity
affects localization		 ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein]; Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein; KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]
Digoxin results in increased activity of HIF1A protein		 CTD PMID:19647009 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of ICAM1 mRNA] CTD PMID:36329302 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]; Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A protein] CTD PMID:22292739 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il23r interleukin 23 receptor multiple interactions EXP Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL23R mRNA] CTD PMID:22292739 NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839 		JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Digoxin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Ins2 insulin II decreases response to substance ISO INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions
affects response to substance
decreases expression
decreases activity		 ISO Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]
KCNH2 gene affects the susceptibility to Digoxin
Digoxin results in decreased expression of KCNH2 protein modified form		 CTD PMID:19139152 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK1 protein] CTD PMID:19687166 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Digoxin results in increased phosphorylation of MAPK3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19687166 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases response to substance EXP NOS3 protein results in decreased susceptibility to Digoxin CTD PMID:11761419 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nppa natriuretic peptide type A multiple interactions
increases expression		 ISO N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA] CTD PMID:19687166 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nppb natriuretic peptide type B increases expression ISO Digoxin results in increased expression of NPPB protein CTD PMID:16032632 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO Digoxin results in decreased activity of PGD protein CTD PMID:26820767 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228 		JBrowse link
G Rorc RAR-related orphan receptor gamma decreases activity
multiple interactions		 EXP Digoxin results in decreased activity of RORC protein
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC protein]		 CTD PMID:21441909 PMID:36329302 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions ISO Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591 		JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 increases expression
multiple interactions		 ISO Digoxin results in increased expression of SLC9A1 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA]		 CTD PMID:19687166 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases activity
affects transport		 EXP
ISO		 Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite]; Elacridar affects the reaction [SLCO1A4 protein affects the transport of Digoxin]
SLCO1A4 protein results in increased uptake of Digoxin
Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
Digoxin results in decreased activity of SLCO1A4 protein		 CTD PMID:11883641 PMID:19833843 PMID:34619012 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions EXP Digoxin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1B2 mRNA] CTD PMID:36329302 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Digoxin inhibits the reaction [TARDBP protein binds to TARDBP protein] CTD PMID:23891805 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digoxin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
dioscin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions ISO dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] CTD PMID:27317372 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases expression ISO dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein CTD PMID:24680847 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions ISO dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] CTD PMID:27317372 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] CTD PMID:24146112 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Acads acyl-Coenzyme A dehydrogenase, short chain multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] CTD PMID:24146112 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:24146112 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] CTD PMID:24146112 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] CTD PMID:24146112 NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions EXP dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] CTD PMID:35481609 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression		 ISO
EXP		 dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA		 CTD PMID:25111127 PMID:29990575 PMID:35481609 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase family 7, member A1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] CTD PMID:24146112 NCBI chr18:56,657,794...56,706,112
Ensembl chr18:56,642,759...56,706,023 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO dioscin results in decreased expression of APAF1 mRNA CTD PMID:33359023 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] CTD PMID:24146112 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO dioscin results in increased expression of BAD mRNA CTD PMID:33359023 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression		 EXP
ISO		 dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein		 CTD PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 EXP
ISO		 dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein		 CTD PMID:22334414 PMID:22939915 PMID:33359023 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein CTD PMID:29990575 PMID:33359023 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
decreases expression		 EXP
ISO		 dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in increased expression of BCL2 protein
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein		 CTD PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 EXP
ISO		 [Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein		 CTD PMID:22334414 PMID:22939915 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO dioscin results in increased expression of BIRC5 mRNA CTD PMID:29990575 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
increases activity		 ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
dioscin results in increased activity of CASP3 protein		 CTD PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases expression ISO dioscin results in increased expression of CASP7 mRNA CTD PMID:29990575 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 increases activity
decreases expression
multiple interactions
increases expression		 ISO dioscin results in increased activity of CASP8 protein
dioscin results in decreased expression of CASP8 mRNA
dioscin results in decreased expression of and results in increased cleavage of CASP8 protein
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein		 CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression
increases expression		 ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein		 CTD PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein CTD PMID:33359023 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein CTD PMID:29990575 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression		 ISO dioscin results in increased expression of CCND1 mRNA
dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein		 CTD PMID:29990575 PMID:33359023 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein CTD PMID:33359023 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression ISO dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein CTD PMID:29990575 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein CTD PMID:33359023 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO dioscin results in decreased expression of CDK4 mRNA CTD PMID:33359023 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdk6 cyclin dependent kinase 6 decreases expression ISO dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein CTD PMID:33359023 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein CTD PMID:29990575 PMID:33359023 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein CTD PMID:33359023 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression ISO dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein CTD PMID:33359023 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein CTD PMID:33359023 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein CTD PMID:29990575 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:24146112 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 EXP
ISO		 fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]
dioscin results in increased expression of CTNNB1 protein
dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein		 CTD PMID:24742230 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO dioscin results in increased expression of CYCS mRNA CTD PMID:33359023 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases expression ISO dioscin results in increased expression of CYP2C9 mRNA CTD PMID:29990575 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] CTD PMID:24146112 NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] CTD PMID:24146112 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO dioscin results in increased expression of DIABLO mRNA CTD PMID:29990575 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases expression
multiple interactions		 EXP
ISO		 dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]		 CTD PMID:24742230 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) increases expression
multiple interactions		 ISO
EXP		 dioscin results in increased expression of ESR2 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein]		 CTD PMID:24742230 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein CTD PMID:22334414 PMID:33359023 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand increases expression ISO dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein CTD PMID:22334414 PMID:29990575 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO dioscin results in increased expression of FOXO1 mRNA CTD PMID:33359023 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] CTD PMID:27317372 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] CTD PMID:24146112 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:24146112 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein] CTD PMID:35481609 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein] CTD PMID:35481609 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein] CTD PMID:35481609 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]		 CTD
RGD		 PMID:24146112 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:25111127 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Krt18 keratin 18 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] CTD PMID:22939915 PMID:24146112 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462 		JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 multiple interactions
increases expression		 EXP fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] CTD PMID:24742230 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24146112 PMID:25111127 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:24146112 PMID:25111127 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO dioscin results in increased expression of MAPK8 mRNA CTD PMID:29990575 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO dioscin results in increased expression of MAPK9 mRNA CTD PMID:29990575 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) multiple interactions EXP dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] CTD PMID:22939915 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO dioscin results in decreased expression of MTOR mRNA CTD PMID:29990575 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions EXP dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] CTD PMID:35481609 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases degradation ISO dioscin results in decreased degradation of NFKBIA protein CTD PMID:24680847 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression		 ISO dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA		 CTD PMID:27317372 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein
dioscin results in increased expression of PARP1 mRNA		 CTD PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta decreases expression ISO dioscin results in decreased expression of PIK3CB mRNA CTD PMID:29990575 NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674 		JBrowse link
G Pnp2 purine-nucleoside phosphorylase 2 multiple interactions EXP dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] CTD PMID:22939915 NCBI chr14:51,193,598...51,202,206
Ensembl chr14:51,193,449...51,202,206 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:24146112 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions EXP dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] CTD PMID:22939915 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit increases expression ISO dioscin results in increased expression of PRKAB1 mRNA CTD PMID:29990575 NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] CTD PMID:25111127 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] CTD PMID:28082111 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rgn regucalcin multiple interactions EXP dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] CTD PMID:22939915 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases expression ISO dioscin results in decreased expression of RPS6KB1 mRNA CTD PMID:29990575 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 multiple interactions ISO dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:27317372 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO dioscin results in increased expression of SLCO1A2 mRNA CTD PMID:27317372 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions
increases expression		 ISO dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA		 CTD PMID:27317372 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Suox sulfite oxidase multiple interactions EXP dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] CTD PMID:22939915 NCBI chr10:128,505,756...128,509,787
Ensembl chr10:128,505,763...128,509,942 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein]
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:35481609 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]		 CTD
RGD		 PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 More... RGD:15090820 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions
increases expression		 EXP fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA] CTD PMID:24742230 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a increases expression ISO dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 increases expression ISO dioscin results in increased expression of TNFRSF25 mRNA CTD PMID:29990575 PMID:33359023 NCBI chr 4:152,199,985...152,204,568
Ensembl chr 4:152,200,391...152,204,576 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 decreases expression
multiple interactions		 EXP dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]		 CTD PMID:24742230 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO dioscin results in increased expression of TRADD mRNA CTD PMID:29990575 PMID:33359023 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO dioscin results in increased expression of TRAF1 protein CTD PMID:22334414 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression		 EXP
ISO		 dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein		 CTD PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wee1 WEE 1 homolog 1 (S. pombe) increases expression ISO dioscin results in increased expression of WEE1 mRNA CTD PMID:29990575 NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493 		JBrowse link
diosgenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions
increases expression		 ISO [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA
Diosgenin results in increased expression of ABCC2 mRNA		 CTD PMID:16105132 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression
multiple interactions		 ISO Diosgenin results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC3 mRNA		 CTD PMID:16105132 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
multiple interactions		 ISO
EXP		 Diosgenin results in increased expression of ABCG5 mRNA
[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA
Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]		 CTD PMID:12963437 PMID:15611112 PMID:16105132 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions
increases expression		 ISO
EXP		 [Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA
Diosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]		 CTD PMID:12963437 PMID:15611112 PMID:16105132 NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression ISO Diosgenin results in decreased expression of ACACA mRNA CTD PMID:32347045 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:16331273 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 multiple interactions ISO Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 protein] CTD PMID:35305976 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] CTD PMID:16331273 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] CTD PMID:35149085 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:28106847 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Diosgenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
Diosgenin results in decreased expression of BCL2 protein		 CTD PMID:16331273 PMID:28106847 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression
multiple interactions		 ISO Diosgenin results in decreased expression of BCL2A1 protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]		 CTD PMID:16331273 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions		 ISO Diosgenin results in decreased expression of BCL2L1 protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]		 CTD PMID:16331273 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression		 ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Diosgenin results in decreased expression of BIRC2 protein		 CTD PMID:16331273 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP3 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]		 CTD PMID:28106847 PMID:35149085 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased expression of CASP9 protein] CTD PMID:35149085 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 EXP Diosgenin results in decreased expression of CCL2 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]		 CTD PMID:26408789 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:16331273 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 protein] CTD PMID:33383043 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions		 ISO Diosgenin results in decreased expression of CFLAR protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]		 CTD PMID:16331273 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP Diosgenin results in decreased expression of CTNNB1 mRNA CTD PMID:26408789 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA] CTD PMID:33383043 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression EXP Diosgenin results in increased expression of CYP3A11 mRNA CTD PMID:15611112 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein] CTD PMID:12963437 PMID:33383043 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Diosgenin affects the reaction [alpha-Chlorohydrin affects the localization of DNM1L protein]
Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of DNM1L protein]		 CTD PMID:35149085 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:35149085 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
increases expression		 EXP Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of ESR2 protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein]
Diosgenin results in increased expression of ESR2 protein		 CTD PMID:26408789 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression
multiple interactions		 EXP Diosgenin results in decreased expression of FABP4 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; rosiglitazone inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]		 CTD PMID:26408789 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Diosgenin results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fgf15 fibroblast growth factor 15 multiple interactions ISO Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA] CTD PMID:33383043 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein] CTD PMID:35149085 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B protein] CTD PMID:35305976 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 EXP
ISO		 Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
Diosgenin results in decreased expression of IL6 mRNA		 CTD PMID:26408789 PMID:35305976 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO Diosgenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; Diosgenin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:24001619 PMID:35305976 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Lipc lipase, hepatic increases activity ISO Diosgenin results in increased activity of LIPC protein CTD PMID:20149787 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases lipidation
multiple interactions		 ISO Diosgenin results in decreased lipidation of MAP1LC3B protein
[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]
3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; [alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased lipidation of MAP1LC3B protein]		 CTD PMID:35149085 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mesp1 mesoderm posterior 1 decreases expression ISO Diosgenin results in decreased expression of MESP1 mRNA; Diosgenin results in decreased expression of MESP1 protein CTD PMID:34806916 NCBI chr 7:79,441,989...79,443,338
Ensembl chr 7:79,441,989...79,443,536 		JBrowse link
G Mest mesoderm specific transcript multiple interactions
decreases expression		 EXP Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
Diosgenin results in decreased expression of MEST mRNA		 CTD PMID:26408789 NCBI chr 6:30,733,505...30,783,580
Ensembl chr 6:30,723,546...30,748,464 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN1 protein] CTD PMID:35149085 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein] CTD PMID:35149085 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression		 ISO Diosgenin results in increased activity of MMP2 protein
Diosgenin results in increased expression of MMP2 mRNA		 CTD PMID:21814480 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity		 ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
Diosgenin results in decreased expression of MMP9 mRNA
Diosgenin results in decreased activity of MMP9 protein		 CTD PMID:16331273 PMID:21814480 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein] CTD PMID:35149085 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:16331273 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:16331273 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:16331273 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 protein] CTD PMID:33383043 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP Diosgenin results in increased activity of NR1I2 protein CTD PMID:15611112 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
decreases response to substance
decreases expression
multiple interactions		 EXP
ISO		 Diosgenin results in increased expression of PPARG protein
Diosgenin results in increased expression of PPARG mRNA
PPARG protein results in decreased susceptibility to Diosgenin
Diosgenin results in decreased expression of PPARG mRNA
[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]		 CTD PMID:24001619 PMID:26408789 PMID:32347045 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:16331273 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
Diosgenin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]		 CTD PMID:16331273 PMID:35305976 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 multiple interactions ISO Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 protein] CTD PMID:35305976 NCBI chr11:116,488,991...116,517,786
Ensembl chr11:116,488,991...116,517,845 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:35149085 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein] CTD PMID:26408789 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 protein] CTD PMID:33383043 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased phosphorylation of STK11 protein] CTD PMID:35149085 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Diosgenin results in decreased activity of TNF protein		 CTD PMID:16331273 PMID:35305976 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions
decreases activity		 EXP Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
Diosgenin results in decreased activity of TNFSF11 protein		 CTD PMID:16331273 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Ulk1 unc-51 like kinase 1 multiple interactions ISO 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein CTD PMID:35149085 NCBI chr 5:110,932,355...110,957,991
Ensembl chr 5:110,932,354...110,957,963 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein] CTD PMID:16331273 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wnt10b wingless-type MMTV integration site family, member 10B decreases expression EXP Diosgenin results in decreased expression of WNT10B mRNA CTD PMID:26408789 NCBI chr15:98,668,593...98,676,093
Ensembl chr15:98,668,593...98,676,031 		JBrowse link
ginsenoside C-K term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:21875580 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein] CTD PMID:21875580 NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma decreases expression EXP ginsenoside M1 results in decreased expression of IFNG mRNA CTD PMID:15914323 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP ginsenoside M1 results in decreased expression of IL1B mRNA CTD PMID:15914323 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 decreases expression EXP ginsenoside M1 results in decreased expression of IL4 mRNA CTD PMID:15914323 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside M1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga4 integrin alpha 4 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467 		JBrowse link
G Itgal integrin alpha L multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310 		JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO ginsenoside M1 results in decreased secretion of MMP9 protein CTD PMID:21875580 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO ginsenoside M1 results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15802804 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO ginsenoside M1 results in decreased expression of and results in decreased activity of NOS2 protein CTD PMID:15802804 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions ISO [ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 decreases response to substance EXP P2RX7 gene mutant form results in decreased susceptibility to ginsenoside M1 CTD PMID:30545933 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP
ISO		 ginsenoside M1 results in decreased expression of PTGS2 mRNA
ginsenoside M1 results in decreased expression of PTGS2 protein		 CTD PMID:15802804 PMID:15914323 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO ginsenoside M1 results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15802804 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance		 ISO
EXP		 ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
ginsenoside M1 results in decreased expression of TNF mRNA
ginsenoside M1 results in decreased susceptibility to TNF protein		 CTD PMID:15914323 PMID:21875580 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
ginsenoside F1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose results in increased expression of CXCL8 mRNA]; ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of CXCL8 protein] CTD PMID:29412148 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein] CTD PMID:29412148 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
ginsenoside F2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:24380838 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
ginsenoside Rb1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein] CTD PMID:19781563 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1A mRNA] CTD PMID:34812491 NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068 		JBrowse link
G Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1B2 mRNA] CTD PMID:34812491 NCBI chr 8:69,541,388...69,566,370
Ensembl chr 8:69,541,298...69,566,363 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression		 ISO ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of BMP2 mRNA]
ginsenoside Rb1 results in increased expression of BMP2 mRNA		 CTD PMID:27470910 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO		 ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]		 CTD PMID:38373586 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] CTD PMID:19781563 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Clcn7 chloride channel, voltage-sensitive 7 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CLCN7 mRNA] CTD PMID:34812491 NCBI chr17:25,352,353...25,381,077
Ensembl chr17:25,352,365...25,381,078 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSB mRNA] CTD PMID:34812491 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSD mRNA] CTD PMID:34812491 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:22386813 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gsdmd gasdermin D multiple interactions EXP
ISO		 ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]		 CTD PMID:38373586 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein		 CTD PMID:19781563 PMID:25422538 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression		 ISO ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]
ginsenoside Rb1 results in increased expression of IGF1 mRNA		 CTD PMID:27470910 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP
ISO		 ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL18 protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL18 protein]		 CTD PMID:38373586 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL1B protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL1B protein]		 CTD PMID:38373586 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:17655881 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgam integrin alpha M multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:17655881 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein] CTD PMID:17655881 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 increases expression ISO ginsenoside Rb1 results in increased expression of KCNE1 CTD PMID:24615935 NCBI chr16:92,142,889...92,156,356
Ensembl chr16:92,142,870...92,156,356 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 affects activity ISO ginsenoside Rb1 affects the activity of KCNH2 protein CTD PMID:15842772 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of LAMP1 mRNA] CTD PMID:34812491 NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Chloroquine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein] CTD PMID:38373586 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP
ISO		 ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]]; ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]		 CTD PMID:38373586 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP ginsenoside Rb1 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions EXP ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:22386813 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects localization
increases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; [ginsenoside Rb1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; ginsenoside Rb1 results in increased activity of and results in increased localization of NFE2L2 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
ginsenoside Rb1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
ginsenoside Rb1 results in increased expression of NFE2L2 mRNA		 CTD PMID:19781563 PMID:22780686 PMID:25422538 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein] CTD PMID:38373586 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions ISO ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rb1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP
ISO		 ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]		 CTD PMID:38373586 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]] CTD PMID:38373586 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein] CTD PMID:22386813 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Runx2 runt related transcription factor 2 increases expression
multiple interactions		 ISO ginsenoside Rb1 results in increased expression of RUNX2 mRNA
ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of RUNX2 mRNA]		 CTD PMID:27470910 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein CTD PMID:25297453 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 ISO ginsenoside Rb1 results in decreased expression of SQSTM1 protein
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]		 CTD PMID:34812491 PMID:38373586 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tfeb transcription factor EB multiple interactions ISO
EXP		 [ginsenoside Rb1 co-treated with alpha-Chlorohydrin] affects the localization of TFEB protein; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of TFEB mRNA]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of and affects the localization of TFEB protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]		 CTD PMID:34812491 PMID:38373586 NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of TGFB1 mRNA]
ginsenoside Rb1 results in increased expression of TGFB1 mRNA		 CTD PMID:27470910 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA] CTD PMID:22386813 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions
decreases response to substance		 EXP ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]
ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein		 CTD PMID:22386813 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
ginsenoside Rb2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression ISO ginsenoside Rb2 results in increased expression of ABCC2 mRNA CTD PMID:23835644 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179