sapogenin - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	sapogenin	go back to main search page
Accession:	CHEBI:26606	browse the term
Definition:	Any organic polycyclic compound that is the aglycon moiety of a saponin; sapogenins may be steroids or triterpenoids.
Synonyms:	related_synonym:	sapogenins

show annotations for term's descendants Sort by:
Rat (536) Mouse (538) Human (541) Chinchilla (0) Bonobo (0) Dog (16) Squirrel (0) Pig (11) Green Monkey (0) Naked Mole-rat (0) All
Genes (541)

<

(20R)-protopanaxadiol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase (Yt blood group)

multiple interactions

protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

BCL2 like 1

increases expression

protopanaxadiol results in increased expression of BCL2L1 mRNA

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

baculoviral IAP repeat containing 5

affects expression

protopanaxadiol affects the expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 3

affects cleavage
increases expression

protopanaxadiol affects the cleavage of CASP3 protein
protopanaxadiol results in increased expression of CASP3 mRNA

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

increases expression
affects expression

protopanaxadiol results in increased expression of CASP9 mRNA
protopanaxadiol affects the expression of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cyclin A2

increases expression

protopanaxadiol results in increased expression of CCNA2 mRNA

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

increases expression

protopanaxadiol results in increased expression of CCNB1 mRNA

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

increases expression

protopanaxadiol results in increased expression of CCND1 mRNA

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cell division cycle 25A

multiple interactions
increases expression

protopanaxadiol results in increased expression of and results in decreased phosphorylation of CDC25A protein
protopanaxadiol results in increased expression of CDC25A mRNA

NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417

G

cell division cycle 25C

increases expression
multiple interactions

protopanaxadiol results in increased expression of CDC25C mRNA
protopanaxadiol affects the expression of and affects the phosphorylation of CDC25C protein

NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355

G

cyclin dependent kinase 1

increases expression

protopanaxadiol results in increased expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 2

increases expression

protopanaxadiol results in increased expression of CDK2 mRNA

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase 4

increases expression

protopanaxadiol results in increased expression of CDK4 mRNA; protopanaxadiol results in increased expression of CDK4 protein

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

choline O-acetyltransferase

multiple interactions

protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]

NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942

G

epidermal growth factor receptor

multiple interactions
decreases activity

protopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR protein
protopanaxadiol results in decreased activity of EGFR protein

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions

protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

mitogen-activated protein kinase kinase 1

increases expression

protopanaxadiol results in increased expression of MAP2K1 mRNA

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

mitogen-activated protein kinase 1

decreases phosphorylation

protopanaxadiol results in decreased phosphorylation of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

decreases phosphorylation

protopanaxadiol results in decreased phosphorylation of MAPK3 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

poly(ADP-ribose) polymerase 1

increases expression

protopanaxadiol results in increased expression of PARP1 mRNA

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

Raf-1 proto-oncogene, serine/threonine kinase

increases phosphorylation

protopanaxadiol results in increased phosphorylation of RAF1 protein

NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201

G

ribosomal protein S6 kinase A1

increases expression

protopanaxadiol results in increased expression of RPS6KA1 mRNA

NCBI chr 1:26,529,761...26,575,025
Ensembl chr 1:26,529,761...26,575,030

G

signal transducer and activator of transcription 3

affects expression

protopanaxadiol affects the expression of STAT3 protein

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

tumor protein p53

increases expression

protopanaxadiol results in increased expression of TP53 mRNA; protopanaxadiol results in increased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

(20S)-ginsenoside Rg3

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2 (JR blood group)

multiple interactions
decreases expression

XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA]

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

acid phosphatase 5, tartrate resistant

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]

NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993

G

androgen receptor

increases degradation
multiple interactions

ginsenoside Rg3 results in increased degradation of AR protein
ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein]

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

amphiregulin

decreases expression

ginsenoside Rg3 results in decreased expression of AREG mRNA

NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005

G

BCL2 associated X, apoptosis regulator

multiple interactions

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of BCL2 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

brain derived neurotrophic factor

multiple interactions

[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

beclin 1

multiple interactions

ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

bone gamma-carboxyglutamate protein

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein]

NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317

G

baculoviral IAP repeat containing 5

decreases expression

ginsenoside Rg3 results in decreased expression of BIRC5 mRNA; ginsenoside Rg3 results in decreased expression of BIRC5 protein

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

bone morphogenetic protein 2

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

G

bone morphogenetic protein receptor type 1A

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]

NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,755,786...86,932,825

G

caspase 1

multiple interactions

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

increases cleavage
multiple interactions

ginsenoside Rg3 results in increased cleavage of CASP3 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP3 protein]

PMID:22101440 PMID:26427350 PMID:31916386

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP9 protein]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions

ginsenoside Rg3 inhibits the reaction [dimethoxon results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cellular communication network factor 1

decreases expression

ginsenoside Rg3 results in decreased expression of CCN1 mRNA

NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589

G

cellular communication network factor 2

decreases expression

ginsenoside Rg3 results in decreased expression of CCN2 mRNA

NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372

G

cadherin 1

multiple interactions

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]

NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537

G

dipeptidyl peptidase 4

multiple interactions

[Xiao-Ke-An results in increased abundance of ginsenoside Rg3] which results in decreased activity of DPP4 protein

NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394

G

epidermal growth factor

multiple interactions

EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions
affects phosphorylation

EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]; ginsenoside Rg3 results in decreased expression of and affects the localization of EGFR protein

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

epithelial cell adhesion molecule

decreases expression

ginsenoside Rg3 results in decreased expression of EPCAM mRNA

NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601

G

fucosyltransferase 4

multiple interactions
decreases expression

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of FUT4 protein]
ginsenoside Rg3 results in decreased expression of FUT4 protein

NCBI chr11:94,543,921...94,549,895
Ensembl chr11:94,543,921...94,549,895

G

heat shock transcription factor 1

multiple interactions
decreases expression

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]
ginsenoside Rg3 results in decreased expression of HSF1 protein

NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720

G

interleukin 1 beta

increases expression
multiple interactions

ginsenoside Rg3 results in increased expression of IL1B protein
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

PMID:14534150 PMID:33050067 PMID:34423507

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

KIT proto-oncogene, receptor tyrosine kinase

decreases expression

ginsenoside Rg3 results in decreased expression of KIT mRNA

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

G

KLF transcription factor 4

decreases expression

ginsenoside Rg3 results in decreased expression of KLF4 mRNA

NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482

G

kallikrein related peptidase 3

multiple interactions

ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 mRNA]; ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 protein]

NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764

G

large tumor suppressor kinase 1

increases expression

ginsenoside Rg3 results in increased expression of LATS1 mRNA

NCBI chr 6:149,658,153...149,718,101
Ensembl chr 6:149,658,153...149,718,105

G

large tumor suppressor kinase 2

increases expression

ginsenoside Rg3 results in increased expression of LATS2 mRNA

NCBI chr13:20,973,036...21,061,586
Ensembl chr13:20,973,036...21,061,586

G

microtubule associated protein 2

increases expression

ginsenoside Rg3 results in increased expression of MAP2 mRNA

NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147

G

marker of proliferation Ki-67

multiple interactions

[ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

matrix metallopeptidase 2

multiple interactions

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

myeloperoxidase

multiple interactions

ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ginsenoside Rg3 results in decreased expression of MYC mRNA

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

Nanog homeobox

decreases expression

ginsenoside Rg3 results in decreased expression of NANOG mRNA

NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146

G

nuclear factor kappa B subunit 1

multiple interactions
increases activity

[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein
ginsenoside Rg3 results in increased activity of NFKB1 protein

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions

[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein; [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NLR family pyrin domain containing 3

multiple interactions

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]
3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108

G

noggin

multiple interactions

NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]]

NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611

G

nitric oxide synthase 2

multiple interactions
increases expression

Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]
ginsenoside Rg3 results in increased expression of NOS2 mRNA

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]

NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751

G

poly(ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ginsenoside Rg3 results in increased cleavage of PARP1 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of PARP1 protein]

PMID:22101440 PMID:24793912 PMID:26427350 PMID:31916386

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

phosphoenolpyruvate carboxykinase 1

increases expression

ginsenoside Rg3 results in increased expression of PCK1 mRNA

NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121

G

POU class 5 homeobox 1

decreases expression

ginsenoside Rg3 results in decreased expression of POU5F1 mRNA

NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731

G

PPARG coactivator 1 alpha

increases expression

ginsenoside Rg3 results in increased expression of PPARGC1A mRNA

NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089

G

prominin 1

decreases expression
multiple interactions

ginsenoside Rg3 results in decreased expression of PROM1 mRNA
XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]

NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378

G

PYD and CARD domain containing

multiple interactions

3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]

NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; ginsenoside Rg3 affects the localization of and results in increased activity of RELA protein
ginsenoside Rg3 results in decreased expression of and results in decreased phosphorylation of RELA protein

PMID:14534150 PMID:33050067

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

RUNX family transcription factor 2

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

spalt like transcription factor 4

decreases expression

ginsenoside Rg3 results in decreased expression of SALL4 mRNA

NCBI chr20:51,782,331...51,802,521
Ensembl chr20:51,782,331...51,802,521

G

sirtuin 1

increases activity

ginsenoside Rg3 results in increased activity of SIRT1 protein

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

solute carrier family 6 member 2

multiple interactions

[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A2 protein]

NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645

G

solute carrier family 6 member 3

multiple interactions

[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]

NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440

G

SMAD family member 2

multiple interactions

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146

G

snail family transcriptional repressor 1

multiple interactions

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]

NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886

G

SRY-box transcription factor 2

decreases expression

ginsenoside Rg3 results in decreased expression of SOX2 mRNA

NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436

G

Sp1 transcription factor

multiple interactions

ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein]

NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446

G

sequestosome 1

multiple interactions

ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein]
3-methyladenine affects the reaction [ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]]; ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

serine/threonine kinase 3

increases expression

ginsenoside Rg3 results in increased expression of STK3 mRNA

NCBI chr 8:98,343,975...98,942,610
Ensembl chr 8:98,371,228...98,942,827

G

serine/threonine kinase 4

increases expression

ginsenoside Rg3 results in increased expression of STK4 mRNA

NCBI chr20:44,966,512...45,080,021
Ensembl chr20:44,966,494...45,084,214

G

transforming growth factor beta 1

multiple interactions

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

Thy-1 cell surface antigen

decreases expression

ginsenoside Rg3 results in decreased expression of THY1 mRNA

NCBI chr11:119,415,476...119,424,985
Ensembl chr11:119,415,476...119,424,985

G

tumor necrosis factor

increases expression
multiple interactions

ginsenoside Rg3 results in increased expression of TNF protein
ginsenoside Rg3 inhibits the reaction [dimethoxon results in increased expression of TNF protein]
ginsenoside Rg3 inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; ginsenoside Rg3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:14534150 PMID:26240163 PMID:33050067

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 11b

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF superfamily member 11

multiple interactions

ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]]

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

G

vimentin

multiple interactions

ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

WW domain containing transcription regulator 1

decreases expression

ginsenoside Rg3 results in decreased expression of WWTR1 mRNA

NCBI chr 3:149,517,235...149,724,788
Ensembl chr 3:149,517,235...149,736,714

G

Yes1 associated transcriptional regulator

decreases expression

ginsenoside Rg3 results in decreased expression of YAP1 mRNA

NCBI chr11:102,110,447...102,233,424
Ensembl chr11:102,110,447...102,233,424

(20S)-ginsenoside Rh1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ginsenoside Rh1 results in increased expression of FOS mRNA

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

intercellular adhesion molecule 1

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 1 beta

multiple interactions

ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 4

decreases expression

ginsenoside Rh1 results in decreased expression of IL4

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

multiple interactions

ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit alpha 4

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940

G

integrin subunit alpha L

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567

G

integrin subunit beta 1

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 2

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases activity

ginsenoside Rh1 results in decreased activity of JUN protein

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

lipoprotein lipase

increases secretion

ginsenoside Rh1 results in increased secretion of LPL protein

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

progesterone receptor

increases expression

ginsenoside Rh1 results in increased expression of PGR protein

NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813

G

peroxisome proliferator activated receptor gamma

multiple interactions

ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

selectin E

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705

G

trefoil factor 1

increases expression

ginsenoside Rh1 results in increased expression of TFF1 mRNA

NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535

G

tumor necrosis factor

multiple interactions
decreases response to substance
decreases expression

ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 results in decreased susceptibility to TNF protein
ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 results in decreased expression of TNF

PMID:16557482 PMID:21875580 PMID:22855946

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

vascular cell adhesion molecule 1

multiple interactions

ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

(20S)-ginsenoside Rh2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ginsenoside Rh2 results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

BCL2 associated X, apoptosis regulator

increases expression

ginsenoside Rh2 results in increased expression of BAX protein

PMID:26482938 PMID:32762018

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

ginsenoside Rh2 results in decreased expression of BCL2 protein

PMID:26482938 PMID:32762018

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

increases cleavage
decreases expression

ginsenoside Rh2 results in increased cleavage of CASP3 protein
ginsenoside Rh2 results in decreased expression of CASP3 protein

PMID:26482938 PMID:32762018

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

decreases expression

ginsenoside Rh2 results in decreased expression of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cyclin D1

decreases expression

ginsenoside Rh2 results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

histone deacetylase 1

decreases expression

ginsenoside Rh2 results in decreased expression of HDAC1 protein

NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635

G

histone deacetylase 2

decreases expression

ginsenoside Rh2 results in decreased expression of HDAC2 protein

NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308

G

histone deacetylase 6

decreases expression

ginsenoside Rh2 results in decreased expression of HDAC6 protein

NCBI chr X:48,801,398...48,824,982
Ensembl chr X:48,801,377...48,824,982

G

interleukin 6

multiple interactions

ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

mitogen-activated protein kinase 1

decreases phosphorylation
increases phosphorylation

ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK1 protein

PMID:26482938 PMID:32762018

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

decreases phosphorylation
increases phosphorylation

ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein
ginsenoside Rh2 results in increased phosphorylation of MAPK3 protein

PMID:26482938 PMID:32762018

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mechanistic target of rapamycin kinase

decreases phosphorylation

ginsenoside Rh2 results in decreased phosphorylation of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

NFKB inhibitor alpha

increases expression

ginsenoside Rh2 results in increased expression of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ginsenoside Rh2 results in increased expression of and results in decreased phosphorylation of RELA protein

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

16alpha,17beta-Estriol 17-(beta-D-glucuronide)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions

estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

Aescin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

increases expression
multiple interactions

Escin results in increased expression of ACACA mRNA
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of ACACA mRNA]
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]; Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acyl-CoA oxidase 1

multiple interactions

ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of ACOX1 mRNA]

NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177

G

autophagy related 5

multiple interactions
increases expression

ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]; ATG5 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG5 protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of ATG5 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG5 protein]]
Escin results in increased expression of ATG5 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of ATG5 protein]

NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791

G

autophagy related 7

multiple interactions

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of ATG7 protein]
Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG7 protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG7 protein]]

NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665

G

beclin 1

multiple interactions
increases expression

Escin inhibits the reaction [Dietary Fats results in decreased expression of BECN1 protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of BECN1 protein]]
Escin results in increased expression of BECN1 protein

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

carnitine palmitoyltransferase 1A

multiple interactions
increases expression

ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]
Escin results in increased expression of CPT1A mRNA

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

carnitine palmitoyltransferase 2

multiple interactions

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of CPT2 mRNA]
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]

NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197

G

cytochrome P450 family 1 subfamily A member 2

increases activity
increases expression

Aescin increased activity of cyp1a2 protein enzyme in rat plasma
Aescin increased expression of Cyp1a2 mRNA in rat liver

RGD

PMID:24252494 PMID:24252494

RGD:401900603, RGD:401900603

NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607

G

Fas cell surface death receptor

decreases expression
multiple interactions

Escin results in decreased expression of FAS mRNA
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]; Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

glutamate-cysteine ligase catalytic subunit

multiple interactions
increases expression

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLC protein]
Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein]]
Escin results in increased expression of GCLC protein

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

multiple interactions
increases expression

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GCLM protein]
Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLM protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLM protein]]
Escin results in increased expression of GCLM protein

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glutamic--pyruvic transaminase

multiple interactions

ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]; Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; Escin inhibits the reaction [tyloxapol results in increased expression of GPT protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

heme oxygenase 1

increases expression
multiple interactions

Escin results in increased expression of HMOX1 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of HMOX1 protein]
Escin inhibits the reaction [Dietary Fats results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of HMOX1 protein]]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

kelch like ECH associated protein 1

multiple interactions
increases expression

Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]; Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]]
Escin results in increased expression of KEAP1 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein]

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

microtubule associated protein 1 light chain 3 beta

multiple interactions
increases lipidation

ATG5 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]; Escin inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]; Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]; NFE2L2 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]
Escin results in increased lipidation of MAP1LC3B protein

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

myosin light chain 9

multiple interactions

[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein; [Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein]; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Calcium] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]

NCBI chr20:36,541,519...36,551,447
Ensembl chr20:36,541,497...36,551,447

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

Escin inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG5 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of ATG7 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of BECN1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of CPT2 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLC protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of GCLM protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]; NFE2L2 protein affects the reaction [Escin promotes the reaction [Dietary Fats results in increased lipidation of MAP1LC3B protein]]
Escin results in increased expression of NFE2L2 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of NFE2L2 protein]; Escin results in increased expression of and affects the localization of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

Escin inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of NQO1 protein]]
Escin results in increased expression of NQO1 protein
Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of NQO1 protein]

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

peroxisome proliferator activated receptor alpha

multiple interactions

ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]; Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]; Escin inhibits the reaction [tyloxapol results in decreased expression of PPARA protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]]

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

peroxisome proliferator activated receptor gamma

multiple interactions
increases expression

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of PPARG protein]
Escin results in increased expression of PPARG protein

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

ras homolog family member A

multiple interactions

[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein]

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

sequestosome 1

multiple interactions

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SQSTM1 protein]
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]; Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]; Escin inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SREBF1 mRNA]; Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of SREBF1 protein]
Escin results in increased expression of SREBF1 mRNA; Escin results in increased expression of SREBF1 protein
ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; ATG5 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]; Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]; Escin inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]]; NFE2L2 protein affects the reaction [Escin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]]

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

alpha-Chaconine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

multiple interactions

alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and affects the localization of JUN protein]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of JUN protein modified form]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

mitogen-activated protein kinase kinase 7

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP2K7 protein]

NCBI chr19:7,903,877...7,914,478
Ensembl chr19:7,903,843...7,914,478

G

mitogen-activated protein kinase kinase kinase 7

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein]

NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086

G

mitogen-activated protein kinase 8

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK9 protein]

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

nitric oxide synthase 2

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

prostaglandin-endoperoxide synthase 2

multiple interactions

alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

tumor necrosis factor

multiple interactions

alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; alpha-chaconine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

alpha-Solamarine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated agonist of cell death

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD protein]

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BCL2 like 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 protein]

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

brain derived neurotrophic factor

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BDNF protein]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

caspase 3

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of CASP3 mRNA]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

cAMP responsive element binding protein 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of CREB1 protein]

NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988

G

discs large MAGUK scaffold protein 4

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]

NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836

G

forkhead box O3

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of FOXO3 protein]

NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774

G

glutamate-cysteine ligase catalytic subunit

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein]

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLM mRNA]

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

high mobility group box 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA]

NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597

G

heme oxygenase 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

interleukin 1 beta

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of IL1B mRNA]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 protein]

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein]

NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751

G

paired related homeobox 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of PRRX1 protein]

NCBI chr 1:170,662,768...170,739,421
Ensembl chr 1:170,662,728...170,739,421

G

synaptophysin like 1

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL1 protein]

NCBI chr 7:106,090,505...106,112,576
Ensembl chr 7:106,090,505...106,112,589

G

tumor necrosis factor

multiple interactions

alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of TNF mRNA]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

Anemoside B4

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

beclin 1

multiple interactions

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BECN1 protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BECN1 protein]

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

caspase 3

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

decreases secretion

anemoside B4 results in decreased secretion of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of CHUK protein]

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of IKBKB protein]

NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460

G

interleukin 1 beta

multiple interactions

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; anemoside B4 inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:32991863 PMID:34051206

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inositol 1,4,5-trisphosphate receptor type 1

decreases phosphorylation

anemoside B4 results in decreased phosphorylation of ITPR1 protein

NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506

G

mitogen-activated protein kinase 1

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

NFKB inhibitor alpha

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nitric oxide synthase 2

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

phospholipase C gamma 1

decreases phosphorylation

anemoside B4 results in decreased phosphorylation of PLCG1 protein

NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801

G

prostaglandin-endoperoxide synthase 2

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

sequestosome 1

multiple interactions

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein]]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

signal transducer and activator of transcription 3

decreases phosphorylation

anemoside B4 results in decreased phosphorylation of STAT3 protein

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

tumor necrosis factor

multiple interactions
decreases secretion

3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; anemoside B4 inhibits the reaction [Cisplatin results in increased expression of TNF protein]; anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
anemoside B4 results in decreased secretion of TNF protein

PMID:32991863 PMID:34051206 PMID:36084722

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

Asiaticoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain derived neurotrophic factor

increases expression
multiple interactions

asiaticoside results in increased expression of BDNF mRNA
asiaticoside inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

catalase

multiple interactions

asiaticoside inhibits the reaction [Rotenone results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cytochrome P450 family 2 subfamily C member 19

decreases activity

asiaticoside results in decreased activity of CYP2C19 protein

NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547

G

cytochrome P450 family 3 subfamily A member 4

decreases activity

asiaticoside results in decreased activity of CYP3A4 protein

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

mitogen-activated protein kinase 14

multiple interactions

asiaticoside inhibits the reaction [Rotenone results in decreased expression of MAPK14 protein]

NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511

G

mechanistic target of rapamycin kinase

multiple interactions

[asiaticoside co-treated with Rotenone] results in decreased expression of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

nerve growth factor

multiple interactions
increases expression

asiaticoside inhibits the reaction [Rotenone results in decreased expression of NGF protein]
asiaticoside results in increased expression of NGF protein

NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770

G

3-phosphoinositide dependent protein kinase 1

multiple interactions

asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 mRNA]; asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 protein]

NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,190

G

phosphatidylethanolamine binding protein 1

multiple interactions

asiaticoside inhibits the reaction [Rotenone results in increased expression of PEBP1 mRNA]

NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584

G

phosphoinositide-3-kinase regulatory subunit 6

multiple interactions

asiaticoside inhibits the reaction [Rotenone results in decreased expression of PIK3R6 mRNA]

NCBI chr17:8,802,722...8,867,677
Ensembl chr17:8,802,722...8,867,677

G

solute carrier family 18 member A2

multiple interactions

asiaticoside inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA]

NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430

G

syntaxin 1A

multiple interactions

[Rotenone co-treated with asiaticoside] results in decreased expression of STX1A mRNA

NCBI chr 7:73,699,210...73,719,669
Ensembl chr 7:73,699,206...73,719,672

G

synaptojanin 1

multiple interactions

[asiaticoside co-treated with Rotenone] results in decreased expression of SYNJ1 mRNA

NCBI chr21:32,628,759...32,728,394
Ensembl chr21:32,628,759...32,728,040

G

tyrosine hydroxylase

multiple interactions

[asiaticoside co-treated with Rotenone] results in decreased expression of TH protein

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

astragaloside IV

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

aquaporin 9

increases expression

astragaloside A results in increased expression of AQP9 mRNA; astragaloside A results in increased expression of AQP9 protein

NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA]

NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093

G

BCL2 associated X, apoptosis regulator

multiple interactions

astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]

PMID:22278385 PMID:33285147 PMID:36322813

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]

PMID:33285147 PMID:36322813

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

multiple interactions

astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCS1L protein]

NCBI chr 2:218,658,743...218,663,443
Ensembl chr 2:218,658,764...218,663,443

G

calcium voltage-gated channel subunit alpha1 C

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein]

NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950

G

caspase 3

multiple interactions

astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CASP3 protein modified form]
astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]

PMID:22278385 PMID:30842369 PMID:33285147 PMID:36322813

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

cyclin D1

increases expression

astragaloside A results in increased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

dual specificity phosphatase 5

decreases expression
multiple interactions

astragaloside IV decreases expression Dusp5 mRNA and protein in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate increases expression of DUSP5 mRNA and protein in Vascular smooth muscle cells]

RGD

PMID:30529164 PMID:30529164

RGD:243048424, RGD:243048424

NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533

G

epidermal growth factor receptor

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

ferritin heavy chain 1

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]

NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634

G

gap junction protein alpha 4

multiple interactions

astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of GJA4 protein]

NCBI chr 1:34,792,999...34,795,747
Ensembl chr 1:34,792,999...34,795,747

G

glutamate-ammonia ligase

multiple interactions

astragaloside A inhibits the reaction [bisphenol A results in decreased activity of GLUL protein]

NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206

G

glutamic--pyruvic transaminase

multiple interactions

astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

astragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2A mRNA]

NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,183,337

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

astragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2B mRNA]

NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002

G

H19 imprinted maternally expressed transcript

increases expression
multiple interactions

astragaloside IV increases expression H19 RNA in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate decreases expression of H19 RNA in Vascular smooth muscle cells]

RGD

PMID:30529164 PMID:30529164

RGD:243048424, RGD:243048424

NCBI chr11:1,995,176...2,001,266
Ensembl chr11:1,995,165...2,004,552

G

histone deacetylase 9

multiple interactions

astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HDAC9 protein]

NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416

G

heme oxygenase 1

multiple interactions
increases expression

[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
astragaloside A results in increased expression of HMOX1 mRNA; astragaloside A results in increased expression of HMOX1 protein

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

interleukin 1 beta

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; astragaloside A inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein]

PMID:25604657 PMID:30842369 PMID:32344236

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]

PMID:25604657 PMID:32344236 PMID:33285147 PMID:36322813

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression
multiple interactions

astragaloside IV decreases expression of Khdrbs1 protein in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate astragaloside IV increases expression of KHDRBS1 protein in Vascular smooth muscle cells]

RGD

PMID:30529164 PMID:30529164

RGD:243048424, RGD:243048424

NCBI chr 1:32,013,868...32,060,850
Ensembl chr 1:32,013,868...32,060,850

G

monoamine oxidase A

multiple interactions

astragaloside A inhibits the reaction [bisphenol A results in increased expression of MAOA protein]

NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817

G

mitogen-activated protein kinase 1

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

matrix metallopeptidase 9

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

myeloperoxidase

multiple interactions

astragaloside A inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein]

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

mechanistic target of rapamycin kinase

multiple interactions
increases phosphorylation

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA
astragaloside IV inhibits the reaction [beta-Glycerophosphate decreases phoshorylation of MTOR protein in Vascular smooth muscle cells]
astragaloside IV increases phosphorylation Mtor protein in thoracic aorta

CTD
RGD

PMID:32344236 PMID:30529164 PMID:30529164

RGD:243048424, RGD:243048424

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

mucin 5B, oligomeric mucus/gel-forming

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA

NCBI chr11:1,223,066...1,262,172
Ensembl chr11:1,223,066...1,262,172

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
astragaloside A affects the localization of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NFKB inhibitor alpha

multiple interactions

astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]

PMID:25604657 PMID:33285147 PMID:36322813

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NFKB inhibitor beta

multiple interactions

astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein]

NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893

G

NLR family pyrin domain containing 3

multiple interactions

astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108

G

proliferating cell nuclear antigen

increases expression

astragaloside A results in increased expression of PCNA protein

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

phospholamban

multiple interactions

astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]

NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716

G

protein tyrosine phosphatase non-receptor type 1

increases expression

Astragaloside IV increases expression of Ptpn1 protein in the hypothalamus

RGD

NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

astragaloside A inhibits the reaction [Taurocholic Acid affects the localization of RELA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]

PMID:25604657 PMID:33285147 PMID:36322813

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

rhodopsin

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA]

NCBI chr 3:129,528,639...129,535,344
Ensembl chr 3:129,528,639...129,535,344

G

retinoid isomerohydrolase RPE65

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA]

NCBI chr 1:68,428,822...68,449,954
Ensembl chr 1:68,428,822...68,451,103

G

solute carrier family 11 member 2

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein]

NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566

G

superoxide dismutase 1

multiple interactions

astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 protein]

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

multiple interactions

astragaloside A promotes the reaction [Taurocholic Acid results in decreased expression of SOD2 protein]; astragaloside A promotes the reaction [Taurocholic Acid results in increased expression of SOD2 mRNA]

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

sequestosome 1

multiple interactions

astragaloside A inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein]

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

transferrin receptor

multiple interactions

astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein

NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789

G

tumor necrosis factor

multiple interactions

[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]

PMID:25604657 PMID:32344236 PMID:33285147 PMID:36322813

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

tryptophan hydroxylase 2

multiple interactions

astragaloside A affects the reaction [bisphenol A affects the expression of TPH2 mRNA]

NCBI chr12:71,938,845...72,032,440
Ensembl chr12:71,938,845...72,186,618

Bacoside a

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase (Yt blood group)

multiple interactions

[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

butyrylcholinesterase

multiple interactions

[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]

NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462

G

catalase

increases activity
multiple interactions

bacoside A results in increased activity of CAT protein
bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

ceruloplasmin

multiple interactions

bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CP protein]

NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829

G

gamma-aminobutyric acid type A receptor subunit alpha1

multiple interactions

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]

NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981

G

gamma-aminobutyric acid type A receptor subunit alpha5

multiple interactions

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]

NCBI chr15:26,866,719...26,949,208
Ensembl chr15:26,866,911...26,949,208

G

gamma-aminobutyric acid type A receptor subunit delta

multiple interactions

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]

NCBI chr 1:2,019,345...2,030,758
Ensembl chr 1:2,019,329...2,030,758

G

glutathione-disulfide reductase

multiple interactions
increases activity

bacoside A inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of GSR protein]
bacoside A results in increased activity of GSR protein

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

matrix metallopeptidase 2

multiple interactions

bacoside A inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased activity of MMP2 protein]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions

bacoside A inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased activity of MMP9 protein]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

Beta-Solamarine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

beta-solamarine promotes the reaction [Cisplatin results in increased expression of BAX protein]
beta-solamarine results in increased expression of BAX protein

PMID:17619073 PMID:20647040

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

decreases expression

beta-solamarine results in decreased expression of BCL2 protein

PMID:17619073 PMID:20647040

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression

beta-solamarine results in decreased expression of BCL2L1 protein

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

caspase 3

increases activity
increases cleavage
multiple interactions

beta-solamarine results in increased activity of CASP3 protein
beta-solamarine results in increased cleavage of CASP3 protein
beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP3 protein]

PMID:17619073 PMID:20647040

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

increases activity
multiple interactions

beta-solamarine results in increased activity of CASP8 protein
beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP8 protein]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases activity
increases cleavage

beta-solamarine promotes the reaction [Cisplatin results in increased activity of CASP9 protein]
beta-solamarine results in increased activity of CASP9 protein
beta-solamarine results in increased cleavage of CASP9 protein

PMID:17619073 PMID:20647040

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cathepsin B

affects localization

beta-solamarine affects the localization of CTSB protein

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

Fas associated via death domain

increases expression

beta-solamarine results in increased expression of FADD protein

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas cell surface death receptor

increases expression

beta-solamarine results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

TNF receptor superfamily member 1A

increases expression

beta-solamarine results in increased expression of TNFRSF1A protein

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNFRSF1A associated via death domain

increases expression

beta-solamarine results in increased expression of TRADD protein

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

Chikusetsusaponin-IV

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 apoptosis regulator

decreases expression

araloside A results in decreased expression of BCL2 protein

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

interleukin 1 beta

decreases expression
decreases secretion

araloside A results in decreased expression of IL1B mRNA
araloside A results in decreased secretion of IL1B protein

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

decreases secretion
decreases expression

araloside A results in decreased secretion of IL6 protein
araloside A results in decreased expression of IL6 mRNA

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

NFKB inhibitor alpha

decreases phosphorylation

araloside A results in decreased phosphorylation of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

RELA proto-oncogene, NF-kB subunit

decreases phosphorylation

araloside A results in decreased phosphorylation of RELA protein

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

Chikusetsusaponin-V

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 12 (gene/pseudogene)

multiple interactions

chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP12 mRNA]

NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670

G

dipeptidyl peptidase 4

multiple interactions

[Xiao-Ke-An results in increased abundance of ginsenoside Ro] which results in decreased activity of DPP4 protein

NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394

G

glycogen synthase kinase 3 beta

increases phosphorylation

ginsenoside Ro results in increased phosphorylation of GSK3B protein

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

heat shock protein family A (Hsp70) member 5

multiple interactions

chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

lipoprotein lipase

increases secretion

ginsenoside Ro results in increased secretion of LPL protein

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

sirtuin 1

multiple interactions

chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein]

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

superoxide dismutase 2

multiple interactions

chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 mRNA]

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

cycloastragenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 9

increases expression

cycloastragenol results in increased expression of AQP9 mRNA; cycloastragenol results in increased expression of AQP9 protein

NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911

G

Rho GTPase activating protein 17

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Arhgap17 protein in myocardium]

RGD

NCBI chr16:24,919,389...25,015,369
Ensembl chr16:24,919,389...25,015,666

G

BCL2 associated X, apoptosis regulator

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Bax protein in myocardium]

RGD

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

cyclin D1

increases expression

cycloastragenol results in increased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

C-X-C motif chemokine ligand 8

multiple interactions

cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of CXCL15 protein]

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

desmocollin 2

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Dsc2 protein in myocardium]

RGD

NCBI chr18:31,058,840...31,102,421
Ensembl chr18:31,058,545...31,102,600

G

glycogen synthase kinase 3 beta

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Gsk3b protein in myocardium]

RGD

NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994

G

interferon gamma

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Ifng protein in spleen]

RGD

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Ikbkg protein in myocardium]

RGD

NCBI chr X:154,541,238...154,565,046
Ensembl chr X:154,541,199...154,565,046

G

interleukin 10

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il10 protein in spleenocytes and peripheral blood]

RGD

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 17A

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il17 protein in spleenocytes and peripheral blood]

RGD

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 1 beta

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il1b protein in spleenocytes and peripheral blood]

RGD

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 4

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Il4 protein in spleen]

RGD

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il6 protein in spleenocytes and peripheral blood]
cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of IL6 protein]

CTD
RGD

PMID:37579952 PMID:32068187

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

matrix metallopeptidase 9

multiple interactions

cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of MMP9 protein]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Mt-co2 protein in myocardium]

RGD

NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269

G

proliferating cell nuclear antigen

increases expression

cycloastragenol results in increased expression of PCNA protein

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

phospholipase C gamma 1

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Plcg1 protein in myocardium]

RGD

NCBI chr20:41,137,543...41,177,626
Ensembl chr20:41,136,960...41,196,801

G

ras homolog family member A

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Rhoa protein in myocardium]

RGD

NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998

G

Ras like without CAAX 2

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Rit2 protein in myocardium]

RGD

NCBI chr18:42,743,227...43,115,685
Ensembl chr18:42,743,227...43,115,691

G

telomerase reverse transcriptase

multiple interactions

cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TERT protein]; cycloastragenol inhibits the reaction [Benzo(a)pyrene results in decreased expression of TERT protein]

NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068

G

tumor necrosis factor

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Tnf protein in spleen]

RGD

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

zinc finger E-box binding homeobox 1

multiple interactions

cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Zeb1 protein in myocardium]

RGD

NCBI chr10:31,318,417...31,529,804
Ensembl chr10:31,318,495...31,529,814

digitonin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin B1

increases expression

Digitonin results in increased expression of CCNB1 protein

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

increases expression

Digitonin results in increased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cadherin 5

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]

NCBI chr16:66,366,691...66,404,784
Ensembl chr16:66,366,690...66,404,784

G

cyclin dependent kinase inhibitor 1A

decreases expression

Digitonin results in decreased expression of CDKN1A protein

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397

G

cyclin dependent kinase inhibitor 1B

decreases expression

Digitonin results in decreased expression of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cytochrome P450 family 2 subfamily B member 6

increases expression

Digitonin results in increased expression of CYP2B10 protein

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

ETS variant transcription factor 2

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]

NCBI chr19:35,641,745...35,644,871
Ensembl chr19:35,641,745...35,644,871

G

GATA binding protein 2

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]

NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201

G

hexosaminidase subunit beta

multiple interactions
increases activity

1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [Digitonin results in increased activity of HEXB protein]

NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Digitonin results in decreased expression of HIF1A protein

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

NIMA related kinase 2

increases expression

Digitonin results in increased expression of NEK2 protein

NCBI chr 1:211,658,256...211,675,621
Ensembl chr 1:211,658,657...211,675,630

G

RB transcriptional corepressor like 2

decreases expression

Digitonin results in decreased expression of RBL2 protein

NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648

G

solute carrier family 22 member 2

multiple interactions

Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

sialophorin

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]

NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876

digoxin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 8

multiple interactions

Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr17:68,867,289...68,955,392
Ensembl chr17:68,867,289...68,955,392

G

ATP binding cassette subfamily B member 1

decreases uptake
affects uptake
increases uptake
multiple interactions
increases export
increases transport
affects secretion
affects binding
affects abundance
increases expression
affects transport

ABCB1 protein results in decreased uptake of Digoxin
ABCB1A protein affects the uptake of Digoxin
ABCB1 protein results in increased uptake of Digoxin
18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [citronellal results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; [Plant Extracts results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [Verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; ABCB1 protein binds to and affects the metabolism of Digoxin; abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Amiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Capsaicin affects the reaction [ABCB1 protein results in increased export of Digoxin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; citronellal inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; cyazofamid affects the reaction [ABCB1 protein results in increased uptake of Digoxin]; dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]; Diltiazem inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Doxazosin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]; gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; manidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Propranolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; rhodioloside affects the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Verapamil inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Digoxin; Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of Digoxin]
ABCB1A protein results in increased uptake of Digoxin
ABCB1 protein affects the secretion of Digoxin
Digoxin binds to ABCB1 protein
ABCB1 gene SNP affects the abundance of Digoxin
Digoxin results in increased expression of ABCB1 mRNA; Digoxin results in increased expression of ABCB1 protein
ABCB1 gene SNP affects the transport of Digoxin; ABCB1 protein affects the transport of Digoxin

PMID:10527640 PMID:10562306 PMID:10617675 PMID:10997946 PMID:11231118 More...

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily G member 2 (JR blood group)

decreases activity

Digoxin results in decreased activity of ABCG2 protein

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

alkaline phosphatase, biomineralization associated

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of ALPL protein]

NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression
multiple interactions

Digoxin results in decreased expression of ATP1A2 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]

NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression
multiple interactions

Digoxin results in decreased expression of ATP1A3 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A3 mRNA]

NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497

G

C-C motif chemokine ligand 2

decreases expression

Digoxin results in decreased expression of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 4

decreases expression

Digoxin results in decreased expression of CCL4 protein

NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621

G

C-C motif chemokine ligand 5

decreases expression

Digoxin results in decreased expression of CCL5 protein

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

C-X-C motif chemokine ligand 10

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL10 protein]

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 8

decreases expression
increases expression

Digoxin results in decreased expression of CXCL8 protein
Digoxin results in increased expression of CXCL8 mRNA

PMID:20116850 PMID:29594315

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

C-X-C motif chemokine ligand 9

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCL9 protein]

NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509

G

C-X-C motif chemokine receptor 3

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein]

NCBI chr X:71,615,919...71,618,511
Ensembl chr X:71,615,916...71,618,511

G

early growth response 1

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of EGR1 protein]

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

FA complementation group D2

multiple interactions

Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]

NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932

G

FA complementation group I

multiple interactions

Digoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261

G

glucose-6-phosphate dehydrogenase

decreases activity

Digoxin results in decreased activity of G6PD protein

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

glial fibrillary acidic protein

increases expression

Digoxin results in increased expression of GFAP mRNA

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

glutamic-oxaloacetic transaminase 1

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GOT1 protein]

NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624

G

glutamic--pyruvic transaminase

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased secretion of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione-disulfide reductase

decreases activity

Digoxin results in decreased activity of GSR protein

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases activity
affects localization

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Digoxin affects the localization of HIF1A protein]; Digoxin results in increased phosphorylation of and results in increased expression of HIF1A protein; KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]
Digoxin results in increased activity of HIF1A protein

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

intercellular adhesion molecule 1

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of ICAM1 mRNA]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interferon gamma

multiple interactions

[Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 17A

multiple interactions

Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]; Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A protein]

NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638

G

interleukin 2

multiple interactions

[Digoxin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 23 receptor

multiple interactions

Digoxin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL23R mRNA]

NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979

G

interleukin 6 receptor

decreases expression

Digoxin results in decreased expression of IL6R protein modified form

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

insulin

decreases response to substance

INS protein results in decreased susceptibility to Digoxin

NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
affects response to substance
decreases expression
decreases activity

Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]
KCNH2 gene affects the susceptibility to Digoxin
Digoxin results in decreased expression of KCNH2 protein modified form

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Digoxin results in increased phosphorylation of MAPK3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

nitric oxide synthase 3

decreases response to substance

NOS3 protein results in decreased susceptibility to Digoxin

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

natriuretic peptide A

multiple interactions
increases expression

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of NPPA mRNA]

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

natriuretic peptide B

increases expression

Digoxin results in increased expression of NPPB protein

NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945

G

nuclear receptor subfamily 1 group H member 4

multiple interactions

Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414

G

phosphogluconate dehydrogenase

decreases activity

Digoxin results in decreased activity of PGD protein

NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511

G

RAR related orphan receptor C

decreases activity
multiple interactions

Digoxin results in decreased activity of RORC protein
Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC protein]

PMID:21441909 PMID:36329302

NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845

G

solute carrier family 22 member 1

multiple interactions

Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718

G

solute carrier family 22 member 3

multiple interactions

Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577

G

solute carrier family 9 member A1

increases expression
multiple interactions

Digoxin results in increased expression of SLC9A1 mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA]

NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981

G

solute carrier organic anion transporter family member 1A2

increases uptake
multiple interactions
decreases activity

SLCO1A4 protein results in increased uptake of Digoxin
Digoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
Digoxin results in decreased activity of SLCO1A4 protein

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

solute carrier organic anion transporter family member 1B3

multiple interactions

Digoxin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1B2 mRNA]

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

TAR DNA binding protein

multiple interactions

Digoxin inhibits the reaction [TARDBP protein binds to TARDBP protein]

NCBI chr 1:11,012,654...11,030,528
Ensembl chr 1:11,012,344...11,030,528

G

vascular endothelial growth factor A

decreases expression

Digoxin results in decreased expression of VEGFA protein

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

dioscin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

decreases expression

dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

multiple interactions

dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily C member 2

multiple interactions

dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein]

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

acyl-CoA dehydrogenase medium chain

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein]

NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575

G

acyl-CoA dehydrogenase short chain

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein]

NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008

G

acyl-CoA oxidase 1

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA]

NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177

G

acyl-CoA synthetase long chain family member 1

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]

NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818

G

acyl-CoA synthetase long chain family member 5

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein]

NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379

G

actin alpha 2, smooth muscle

multiple interactions

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA

PMID:25111127 PMID:29990575 PMID:35481609

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

aldehyde dehydrogenase 7 family member A1

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein]

NCBI chr 5:126,541,841...126,595,219
Ensembl chr 5:126,531,200...126,595,362

G

apoptotic peptidase activating factor 1

decreases expression

dioscin results in decreased expression of APAF1 mRNA

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433

G

activating transcription factor 6

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein]

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

BCL2 associated agonist of cell death

increases expression

dioscin results in increased expression of BAD mRNA

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BCL2 antagonist/killer 1

multiple interactions
increases expression

dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein

PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein

PMID:22334414 PMID:22939915 PMID:33359023

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 binding component 3

increases expression

dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein

PMID:29990575 PMID:33359023

NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766

G

BCL2 apoptosis regulator

multiple interactions
increases expression
decreases expression

dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in increased expression of BCL2 protein
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein

PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

decreases expression

dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BH3 interacting domain death agonist

multiple interactions
decreases expression

[Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein

PMID:22334414 PMID:22939915

NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770

G

baculoviral IAP repeat containing 5

increases expression

dioscin results in increased expression of BIRC5 mRNA

NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636

G

caspase 10

increases expression

dioscin results in increased expression of CASP10 mRNA

PMID:29990575 PMID:33359023

NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428

G

caspase 3

multiple interactions
decreases expression
increases expression
increases activity

dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
dioscin results in increased activity of CASP3 protein

PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 7

increases expression

dioscin results in increased expression of CASP7 mRNA

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 8

increases activity
multiple interactions
decreases expression
increases expression

dioscin results in increased activity of CASP8 protein
dioscin results in decreased expression of and results in increased cleavage of CASP8 protein
dioscin results in decreased expression of CASP8 mRNA
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
decreases expression
increases expression

dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein

PMID:24146112 PMID:29990575 PMID:33359023

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cyclin A2

decreases expression

dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

decreases expression

dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin D1

increases expression
decreases expression

dioscin results in increased expression of CCND1 mRNA
dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein

PMID:29990575 PMID:33359023

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin E1

decreases expression

dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

cyclin dependent kinase 1

decreases expression

dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 2

decreases expression

dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein

NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789

G

cyclin dependent kinase 4

decreases expression

dioscin results in decreased expression of CDK4 mRNA

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase 6

decreases expression

dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein

NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573

G

cyclin dependent kinase inhibitor 1A

increases expression

dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein

PMID:29990575 PMID:33359023

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397

G

cyclin dependent kinase inhibitor 1B

increases expression

dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cyclin dependent kinase inhibitor 2A

increases expression

dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

checkpoint kinase 1

decreases expression

dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

decreases expression

dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

carnitine palmitoyltransferase 1A

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

catenin beta 1

increases expression
multiple interactions

dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cytochrome c, somatic

increases expression

dioscin results in increased expression of CYCS mRNA

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 2 subfamily C member 9

increases expression

dioscin results in increased expression of CYP2C9 mRNA

NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]

PMID:22939915 PMID:24146112

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

diacylglycerol O-acyltransferase 1

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA]

NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910

G

diacylglycerol O-acyltransferase 2

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA]

NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535

G

diablo IAP-binding mitochondrial protein

increases expression

dioscin results in increased expression of DIABLO mRNA

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

estrogen receptor 1

increases expression
multiple interactions

dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

estrogen receptor 2

multiple interactions
increases expression

fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein]

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

Fas associated via death domain

increases expression

dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390

G

Fas cell surface death receptor

increases expression

dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein

PMID:22334414 PMID:33359023

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression

dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein

PMID:22334414 PMID:29990575

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

forkhead box O1

increases expression

dioscin results in increased expression of FOXO1 mRNA

NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641

G

glutamic--pyruvic transaminase

multiple interactions

dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione-disulfide reductase

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein]

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

high mobility group box 1

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597

G

heme oxygenase 1

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heat shock protein family A (Hsp70) member 5

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

intercellular adhesion molecule 1

multiple interactions

dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver]

RGD

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interleukin 13

multiple interactions

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein]

NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110

G

interleukin 1 beta

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 4

multiple interactions

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 5

multiple interactions

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein]

NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838

G

interleukin 6

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]

CTD
RGD

PMID:24146112 PMID:28082111 PMID:29091898

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

kinase insert domain receptor

multiple interactions

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

kelch like ECH associated protein 1

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein]

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

keratin 18

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein]

PMID:22939915 PMID:24146112

NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906

G

LDL receptor related protein 5

increases expression
multiple interactions

dioscin results in increased expression of LRP5 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]

NCBI chr11:68,298,412...68,449,275
Ensembl chr11:68,312,591...68,449,275

G

mitogen-activated protein kinase 1

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]

PMID:24146112 PMID:25111127

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]

PMID:24146112 PMID:25111127

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

increases expression

dioscin results in increased expression of MAPK8 mRNA

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

increases expression

dioscin results in increased expression of MAPK9 mRNA

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

malate dehydrogenase 1

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein]

NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197

G

mechanistic target of rapamycin kinase

decreases expression

dioscin results in decreased expression of MTOR mRNA

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA]

NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138

G

NFE2 like bZIP transcription factor 2

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

multiple interactions

dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver]

RGD

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

decreases degradation

dioscin results in decreased degradation of NFKBIA protein

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver]

RGD

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 0 group B member 2

multiple interactions
increases expression

dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA

NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975

G

nuclear receptor subfamily 1 group H member 4

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414

G

poly(ADP-ribose) polymerase 1

multiple interactions
decreases expression
increases expression

dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein
dioscin results in increased expression of PARP1 mRNA

PMID:24146112 PMID:29990575 PMID:33359023

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

decreases expression

dioscin results in decreased expression of PIK3CB mRNA

NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,336...138,834,928

G

purine nucleoside phosphorylase

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein]

NCBI chr14:20,469,406...20,477,089
Ensembl chr14:20,461,992...20,477,094

G

peroxisome proliferator activated receptor alpha

multiple interactions

dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein]

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

peroxiredoxin 1

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein]

NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver]

RGD

NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374

G

protein kinase AMP-activated non-catalytic subunit beta 1

increases expression

dioscin results in increased expression of PRKAB1 mRNA

NCBI chr12:119,667,952...119,681,619
Ensembl chr12:119,667,864...119,681,624

G

prostaglandin-endoperoxide synthase 2

multiple interactions

dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver]

RGD

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine kinase 2

multiple interactions

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]

NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

regucalcin

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein]

NCBI chr X:47,078,443...47,093,313
Ensembl chr X:47,078,355...47,093,314

G

ribosomal protein S6 kinase B1

decreases expression

dioscin results in decreased expression of RPS6KB1 mRNA

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

solute carrier family 10 member 1

multiple interactions

dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier organic anion transporter family member 1A2

increases expression

dioscin results in increased expression of SLCO1A2 mRNA

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

solute carrier organic anion transporter family member 1B3

multiple interactions
increases expression

dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]

NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050

G

sulfite oxidase

multiple interactions

dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein]

NCBI chr12:55,997,276...56,005,525
Ensembl chr12:55,997,180...56,006,641

G

transforming growth factor beta 1

multiple interactions

dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions
increases expression

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]

CTD
RGD

PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF receptor superfamily member 10b

increases expression

dioscin results in increased expression of TNFRSF10B mRNA

PMID:29990575 PMID:33359023

NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031

G

TNF receptor superfamily member 11b

increases expression
multiple interactions

dioscin results in increased expression of TNFRSF11B mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF receptor superfamily member 1A

increases expression

dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF receptor superfamily member 25

increases expression

dioscin results in increased expression of TNFRSF25 mRNA

PMID:29990575 PMID:33359023

NCBI chr 1:6,460,786...6,466,173
Ensembl chr 1:6,460,786...6,466,175

G

TNF superfamily member 11

decreases expression
multiple interactions

dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

G

tumor protein p53

multiple interactions
increases expression

dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein

PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

TNFRSF1A associated via death domain

increases expression

dioscin results in increased expression of TRADD mRNA

PMID:29990575 PMID:33359023

NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909

G

TNF receptor associated factor 1

increases expression

dioscin results in increased expression of TRAF1 protein

NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173

G

vascular endothelial growth factor A

multiple interactions

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

WEE1 G2 checkpoint kinase

increases expression

dioscin results in increased expression of WEE1 mRNA

NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457

diosgenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA
Diosgenin results in increased expression of ABCC2 mRNA

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions

Diosgenin results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC3 mRNA

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily G member 5

increases expression
multiple interactions

Diosgenin results in increased expression of ABCG5 mRNA
[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA
Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]

PMID:12963437 PMID:15611112 PMID:16105132

NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865

G

ATP binding cassette subfamily G member 8

increases expression
multiple interactions

Diosgenin results in increased expression of ABCG8 mRNA
[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA
Diosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]

PMID:12963437 PMID:15611112 PMID:16105132

NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988

G

acetyl-CoA carboxylase alpha

decreases expression

Diosgenin results in decreased expression of ACACA mRNA

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acid phosphatase 5, tartrate resistant

multiple interactions

Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]

NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993

G

ADAM metallopeptidase domain 17

multiple interactions

Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 protein]

NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732

G

AKT serine/threonine kinase 1

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

apoptotic peptidase activating factor 1

multiple interactions

3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433

G

BCL2 associated X, apoptosis regulator

multiple interactions

[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of BAX protein]

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Diosgenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
Diosgenin results in decreased expression of BCL2 protein

PMID:16331273 PMID:28106847

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 related protein A1

multiple interactions
decreases expression

Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]
Diosgenin results in decreased expression of BCL2A1 protein

NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196

G

BCL2 like 1

decreases expression
multiple interactions

Diosgenin results in decreased expression of BCL2L1 protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

baculoviral IAP repeat containing 2

multiple interactions
decreases expression

Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Diosgenin results in decreased expression of BIRC2 protein

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

caspase 3

multiple interactions

Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP3 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]

PMID:28106847 PMID:35149085

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 9

multiple interactions

3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased expression of CASP9 protein]

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

Diosgenin results in decreased expression of CCL2 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cyclin D1

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

carboxylesterase 1

multiple interactions

Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 protein]

NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337

G

CASP8 and FADD like apoptosis regulator

decreases expression
multiple interactions

Diosgenin results in decreased expression of CFLAR protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]

NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687

G

catenin beta 1

decreases expression

Diosgenin results in decreased expression of CTNNB1 mRNA

NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096

G

cytochrome P450 family 27 subfamily A member 1

multiple interactions

Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA]

NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein]

PMID:12963437 PMID:33383043

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

dynamin 1 like

multiple interactions

Diosgenin affects the reaction [alpha-Chlorohydrin affects the localization of DNM1L protein]
Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of DNM1L protein]

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365

G

estrogen receptor 2

multiple interactions
increases expression

Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of ESR2 protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein]
Diosgenin results in increased expression of ESR2 protein

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

fatty acid binding protein 4

decreases expression
multiple interactions

Diosgenin results in decreased expression of FABP4 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; rosiglitazone inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]

NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236

G

Fas cell surface death receptor

decreases expression

Diosgenin results in decreased expression of FAS mRNA

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

fibroblast growth factor 19

multiple interactions

Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA]

NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022

G

fission, mitochondrial 1

multiple interactions

Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein]

NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316

G

interleukin 1 beta

multiple interactions

Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions
decreases expression

Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
Diosgenin results in decreased expression of IL6 mRNA

PMID:26408789 PMID:35305976

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

INS-IGF2 readthrough

multiple interactions

Diosgenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; Diosgenin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

PMID:24001619 PMID:35305976

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

G

lipase C, hepatic type

increases activity

Diosgenin results in increased activity of LIPC protein

NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844

G

microtubule associated protein 1 light chain 3 beta

decreases lipidation
multiple interactions

Diosgenin results in decreased lipidation of MAP1LC3B protein
3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; [alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased lipidation of MAP1LC3B protein]

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

mesoderm posterior bHLH transcription factor 1

decreases expression

Diosgenin results in decreased expression of MESP1 mRNA; Diosgenin results in decreased expression of MESP1 protein

NCBI chr15:89,732,446...89,751,249
Ensembl chr15:89,749,875...89,751,249

G

mesoderm specific transcript

multiple interactions
decreases expression

Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
Diosgenin results in decreased expression of MEST mRNA

NCBI chr 7:130,486,175...130,506,465
Ensembl chr 7:130,486,171...130,506,465

G

mitofusin 1

multiple interactions

Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN1 protein]

NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936

G

mitofusin 2

multiple interactions

Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein]

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

matrix metallopeptidase 2

increases activity
increases expression

Diosgenin results in increased activity of MMP2 protein
Diosgenin results in increased expression of MMP2 mRNA

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions
decreases expression
decreases activity

Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
Diosgenin results in decreased expression of MMP9 mRNA
Diosgenin results in decreased activity of MMP9 protein

PMID:16331273 PMID:21814480

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

mechanistic target of rapamycin kinase

multiple interactions

3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein]

NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951

G

nuclear factor kappa B subunit 1

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

nuclear receptor subfamily 1 group H member 4

multiple interactions

Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 protein]

NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414

G

nuclear receptor subfamily 1 group I member 2

increases activity

Diosgenin results in increased activity of NR1I2 protein

NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487

G

peroxisome proliferator activated receptor gamma

increases expression
decreases response to substance
decreases expression
multiple interactions

Diosgenin results in increased expression of PPARG protein
Diosgenin results in increased expression of PPARG mRNA
PPARG protein results in decreased susceptibility to Diosgenin
Diosgenin results in decreased expression of PPARG mRNA
[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]

PMID:24001619 PMID:26408789 PMID:32347045

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
Diosgenin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]

PMID:16331273 PMID:35305976

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

rhomboid 5 homolog 2

multiple interactions

Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 protein]

NCBI chr17:76,470,893...76,501,427
Ensembl chr17:76,470,891...76,501,790

G

ribosomal protein S6 kinase B1

multiple interactions

3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

retinoid X receptor alpha

multiple interactions

[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein]

NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585

G

scavenger receptor class B member 1

multiple interactions

Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 protein]

NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668

G

serine/threonine kinase 11

multiple interactions

Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased phosphorylation of STK11 protein]

NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431

G

tumor necrosis factor

multiple interactions
decreases activity

Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Diosgenin results in decreased activity of TNF protein

PMID:16331273 PMID:35305976

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF superfamily member 11

multiple interactions
decreases activity

Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
Diosgenin results in decreased activity of TNFSF11 protein

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

G

unc-51 like autophagy activating kinase 1

multiple interactions

3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein

NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150

G

vascular endothelial growth factor A

multiple interactions

Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]

NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487

G

Wnt family member 10B

decreases expression

Diosgenin results in decreased expression of WNT10B mRNA

NCBI chr12:48,965,340...48,971,735
Ensembl chr12:48,965,340...48,971,735

ginsenoside C-K

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

C-X-C motif chemokine receptor 1

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]

NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962

G

intercellular adhesion molecule 1

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615

G

interferon gamma

decreases expression

ginsenoside M1 results in decreased expression of IFNG mRNA

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

interleukin 1 beta

decreases expression

ginsenoside M1 results in decreased expression of IL1B mRNA

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 4

decreases expression

ginsenoside M1 results in decreased expression of IL4 mRNA

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

multiple interactions

ginsenoside M1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit alpha 4

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940

G

integrin subunit alpha L

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567

G

integrin subunit beta 1

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 2

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]

NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989

G

matrix metallopeptidase 9

decreases secretion

ginsenoside M1 results in decreased secretion of MMP9 protein

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

nuclear factor kappa B subunit 1

multiple interactions

ginsenoside M1 results in decreased activity of [NFKB1 protein binds to RELA protein]

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

nitric oxide synthase 2

multiple interactions

ginsenoside M1 results in decreased expression of and results in decreased activity of NOS2 protein

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

purinergic receptor P2X 4

multiple interactions

[ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

NCBI chr12:121,210,129...121,234,106
Ensembl chr12:121,210,065...121,234,106

G

purinergic receptor P2X 7

decreases response to substance

P2RX7 gene mutant form results in decreased susceptibility to ginsenoside M1

NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032

G

prostaglandin-endoperoxide synthase 2

decreases expression

ginsenoside M1 results in decreased expression of PTGS2 mRNA
ginsenoside M1 results in decreased expression of PTGS2 protein

PMID:15802804 PMID:15914323

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ginsenoside M1 results in decreased activity of [NFKB1 protein binds to RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

selectin E

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705

G

tumor necrosis factor

multiple interactions
decreases expression
decreases response to substance

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; ginsenoside M1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
ginsenoside M1 results in decreased expression of TNF mRNA
ginsenoside M1 results in decreased susceptibility to TNF protein

PMID:15914323 PMID:21875580

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

vascular cell adhesion molecule 1

multiple interactions

ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045

ginsenoside F1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

multiple interactions

ginsenoside F1 inhibits the reaction [Galactose results in increased expression of CXCL8 mRNA]; ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of CXCL8 protein]

NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716

G

interleukin 6

multiple interactions

ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ginsenoside F1 inhibits the reaction [Galactose affects the localization of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

ginsenoside F2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions

ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

ginsenoside Rb1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

ATPase H+ transporting V1 subunit A

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1A mRNA]

NCBI chr 3:113,747,035...113,812,056
Ensembl chr 3:113,746,770...113,812,056

G

ATPase H+ transporting V1 subunit B2

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6V1B2 mRNA]

NCBI chr 8:20,197,381...20,221,696
Ensembl chr 8:20,197,381...20,230,399

G

bone morphogenetic protein 2

multiple interactions
increases expression

ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of BMP2 mRNA]
ginsenoside Rb1 results in increased expression of BMP2 mRNA

NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246

G

caspase 1

multiple interactions

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP1 protein]

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions

ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

chloride voltage-gated channel 7

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CLCN7 mRNA]

NCBI chr16:1,444,935...1,475,028
Ensembl chr16:1,444,934...1,475,077

G

cathepsin B

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSB mRNA]

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cathepsin D

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of CTSD mRNA]

NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

gasdermin D

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]

NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062

G

heme oxygenase 1

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein

PMID:19781563 PMID:25422538

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

insulin like growth factor 1

multiple interactions
increases expression

ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]
ginsenoside Rb1 results in increased expression of IGF1 mRNA

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

interleukin 18

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL18 protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL18 protein]

NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096

G

interleukin 1 beta

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased secretion of IL1B protein]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of IL1B protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

integrin subunit alpha M

multiple interactions

ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

integrin subunit beta 2

multiple interactions

ginsenoside Rb1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]

NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989

G

potassium voltage-gated channel subfamily E regulatory subunit 1

increases expression

ginsenoside Rb1 results in increased expression of KCNE1

NCBI chr21:34,446,688...34,512,210
Ensembl chr21:34,446,688...34,512,214

G

potassium voltage-gated channel subfamily H member 2

affects activity

ginsenoside Rb1 affects the activity of KCNH2 protein

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

lysosomal associated membrane protein 1

multiple interactions

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of LAMP1 mRNA]

NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672

G

lactate dehydrogenase A

multiple interactions

Chloroquine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]

NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]]; ginsenoside Rb1 promotes the reaction [alpha-Chlorohydrin results in increased lipidation of and results in increased localization of MAP1LC3B protein]

NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779

G

microtubule associated protein 2

increases expression

ginsenoside Rb1 results in increased expression of MAP2 mRNA

NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147

G

nuclear factor of activated T cells 1

multiple interactions

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]

NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; [ginsenoside Rb1 co-treated with ginsenoside 20S-protopanaxatriol] results in increased expression of NFE2L2 protein; fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; ginsenoside Rb1 results in increased activity of and results in increased localization of NFE2L2 protein; Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]
ginsenoside Rb1 affects the localization of NFE2L2 protein
[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
ginsenoside Rb1 results in increased expression of NFE2L2 mRNA

PMID:19781563 PMID:22780686 PMID:25422538

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NLR family pyrin domain containing 3

multiple interactions

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein]

NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108

G

purinergic receptor P2X 4

multiple interactions

ginsenoside Rb1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]

NCBI chr12:121,210,129...121,234,106
Ensembl chr12:121,210,065...121,234,106

G

progesterone receptor

increases expression

ginsenoside Rb1 results in increased expression of PGR protein

NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813

G

PTEN induced kinase 1

multiple interactions

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]

NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]

NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

RUNX family transcription factor 2

increases expression
multiple interactions

ginsenoside Rb1 results in increased expression of RUNX2 mRNA
ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of RUNX2 mRNA]

NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349

G

solute carrier organic anion transporter family member 1B3

multiple interactions

ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

G

sequestosome 1

multiple interactions
decreases expression

ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]
Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]
ginsenoside Rb1 results in decreased expression of SQSTM1 protein

PMID:34812491 PMID:38373586

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

transcription factor EB

multiple interactions

[ginsenoside Rb1 co-treated with alpha-Chlorohydrin] affects the localization of TFEB protein; ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of TFEB mRNA]
ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of and affects the localization of TFEB protein]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PARK protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in decreased expression of PINK1 protein]]; TFEB protein promotes the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]]

PMID:34812491 PMID:38373586

NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259

G

transforming growth factor beta 1

multiple interactions
increases expression

ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of TGFB1 mRNA]
ginsenoside Rb1 results in increased expression of TGFB1 mRNA

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF superfamily member 11

multiple interactions
decreases response to substance

ginsenoside Rb1 inhibits the reaction [TNFSF11 protein affects the localization of RELA protein]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of TNF mRNA]
ginsenoside Rb1 results in decreased susceptibility to TNFSF11 protein

NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013

ginsenoside Rb2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

ginsenoside Rb2 results in increased expression of ABCC2 mRNA

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

lipoprotein lipase

increases secretion
decreases secretion

ginsenoside Rb2 results in increased secretion of LPL protein
ginsenoside Rb2 results in decreased secretion of LPL protein

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

ginsenoside Rc

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1B3

multiple interactions

ginsenoside Rc binds to and results in decreased activity of SLCO1B3 protein

NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911

ginsenoside Rd

term browser

Symbol

Object Name

Qualifiers

Evidence