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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sapogenin
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Accession:CHEBI:26606 term browser browse the term
Definition:Any organic polycyclic compound that is the aglycon moiety of a saponin; sapogenins may be steroids or triterpenoids.
Synonyms:related_synonym: sapogenins


show annotations for term's descendants           Sort by:
(20R)-protopanaxadiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:29133030 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO protopanaxadiol results in increased expression of BCL2L1 mRNA CTD PMID:31805304 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression ISO protopanaxadiol affects the expression of BIRC5 protein CTD PMID:31805304 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp3 caspase 3 increases expression
affects cleavage 		ISO protopanaxadiol results in increased expression of CASP3 mRNA
protopanaxadiol affects the cleavage of CASP3 protein 		CTD PMID:31805304 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases expression
affects expression 		ISO protopanaxadiol results in increased expression of CASP9 mRNA
protopanaxadiol affects the expression of CASP9 protein 		CTD PMID:31805304 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccna2 cyclin A2 increases expression ISO protopanaxadiol results in increased expression of CCNA2 mRNA CTD PMID:31805304 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO protopanaxadiol results in increased expression of CCNB1 mRNA CTD PMID:31805304 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO protopanaxadiol results in increased expression of CCND1 mRNA CTD PMID:31805304 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
increases expression 		ISO protopanaxadiol results in increased expression of and results in decreased phosphorylation of CDC25A protein
protopanaxadiol results in increased expression of CDC25A mRNA 		CTD PMID:31805304 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188 		JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions 		ISO protopanaxadiol results in increased expression of CDC25C mRNA
protopanaxadiol affects the expression of and affects the phosphorylation of CDC25C protein 		CTD PMID:31805304 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO protopanaxadiol results in increased expression of CDK1 mRNA CTD PMID:31805304 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO protopanaxadiol results in increased expression of CDK2 mRNA CTD PMID:31805304 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO protopanaxadiol results in increased expression of CDK4 mRNA; protopanaxadiol results in increased expression of CDK4 protein CTD PMID:31805304 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:29133030 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases activity 		ISO protopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR protein
protopanaxadiol results in decreased activity of EGFR protein 		CTD PMID:31805304 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] CTD PMID:29133030 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein] CTD PMID:29133030 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein] CTD PMID:29133030 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO protopanaxadiol results in increased expression of MAP2K1 mRNA CTD PMID:31805304 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK1 protein CTD PMID:31805304 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK3 protein CTD PMID:31805304 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO protopanaxadiol results in increased expression of PARP1 mRNA CTD PMID:31805304 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases phosphorylation ISO protopanaxadiol results in increased phosphorylation of RAF1 protein CTD PMID:31805304 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 increases expression ISO protopanaxadiol results in increased expression of RPS6KA1 mRNA CTD PMID:31805304 NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO protopanaxadiol affects the expression of STAT3 protein CTD PMID:31805304 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO protopanaxadiol results in increased expression of TP53 mRNA; protopanaxadiol results in increased expression of TP53 protein CTD PMID:31805304 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
cycloastragenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 increases expression ISO cycloastragenol results in increased expression of AQP9 mRNA; cycloastragenol results in increased expression of AQP9 protein CTD PMID:37918281 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Arhgap17 Rho GTPase activating protein 17 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Arhgap17 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:187,238,380...187,327,936 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Bax protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cycloastragenol results in increased expression of CCND1 protein CTD PMID:37918281 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Dsc2 desmocollin 2 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Dsc2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,725,466...11,757,466 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Gsk3b protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Ifng interferon gamma multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Ifng protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Ikbkg protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il10 protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il17 protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il1b protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Il4 protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO 		cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il6 protein in spleenocytes and peripheral blood]
cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of IL6 protein] 		CTD
RGD		 PMID:37579952 PMID:32068187 RGD:267358468 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of MMP9 protein] CTD PMID:37579952 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Mt-co2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO cycloastragenol results in increased expression of PCNA protein CTD PMID:37918281 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Plcg1 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Rhoa protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rit2 Ras-like without CAAX 2 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Rit2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:22,839,914...23,196,137
Ensembl chr18:22,839,915...23,269,823 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TERT protein]; cycloastragenol inhibits the reaction [Benzo(a)pyrene results in decreased expression of TERT protein] CTD PMID:37579952 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Tnf protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Zeb1 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745 		JBrowse link
diosgenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression 		EXP [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA
Diosgenin results in increased expression of ABCC2 mRNA 		CTD PMID:16105132 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions 		EXP Diosgenin results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC3 mRNA 		CTD PMID:16105132 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
multiple interactions 		EXP
ISO 		Diosgenin results in increased expression of ABCG5 mRNA
[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA
Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol] 		CTD PMID:12963437 PMID:15611112 PMID:16105132 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression
multiple interactions 		EXP
ISO 		Diosgenin results in increased expression of ABCG8 mRNA
[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA
Diosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol] 		CTD PMID:12963437 PMID:15611112 PMID:16105132 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Diosgenin results in decreased expression of ACACA mRNA CTD PMID:32347045 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:16331273 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]
Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]] 		CTD PMID:39059093 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of ADAM17 protein] CTD PMID:35305976 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] CTD PMID:16331273 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] CTD PMID:35149085 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:28106847 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO
EXP 		Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Diosgenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
Diosgenin results in decreased expression of BCL2 protein 		CTD PMID:16331273 PMID:28106847 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions
decreases expression 		ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]
Diosgenin results in decreased expression of BCL2A1 protein 		CTD PMID:16331273 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of BCL2L1 protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] 		CTD PMID:16331273 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression 		ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Diosgenin results in decreased expression of BIRC2 protein 		CTD PMID:16331273 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP3 protein]
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Diosgenin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein] 		CTD PMID:28106847 PMID:35149085 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]; Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased expression of CASP9 protein] CTD PMID:35149085 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of CCL2 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA] 		CTD PMID:26408789 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:16331273 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh5 cadherin 5 multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]
Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]] 		CTD PMID:39059093 NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions EXP Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of CES1 protein] CTD PMID:33383043 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of CFLAR protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein] 		CTD PMID:16331273 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of COL1A1 mRNA] CTD PMID:39059093 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of COL3A1 mRNA] CTD PMID:39059093 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Diosgenin results in decreased expression of CTNNB1 mRNA CTD PMID:26408789 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions EXP Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA] CTD PMID:33383043 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Diosgenin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein] CTD PMID:12963437 PMID:33383043 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO
EXP 		Diosgenin affects the reaction [alpha-Chlorohydrin affects the localization of DNM1L protein]
Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of DNM1L protein] 		CTD PMID:35149085 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:35149085 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression 		ISO Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of ESR2 protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein]
Diosgenin results in increased expression of ESR2 protein 		CTD PMID:26408789 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
multiple interactions 		ISO Diosgenin results in decreased expression of FABP4 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; rosiglitazone inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA] 		CTD PMID:26408789 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Diosgenin results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FASN protein] 		CTD PMID:39536891 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA] CTD PMID:33383043 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of FIS1 protein] CTD PMID:35149085 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Diosgenin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:39536891 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of HIF1A mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of HIF1A protein] 		CTD PMID:39536891 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Diosgenin co-treated with Ecdysterone] results in increased expression of IGF1 mRNA CTD PMID:39395682 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]; Diosgenin inhibits the reaction [MTOR protein promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]] 		CTD PMID:35305976 PMID:39536891 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO
EXP 		Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL6 protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL6 protein]]
Diosgenin results in decreased expression of IL6 mRNA 		CTD PMID:26408789 PMID:35305976 PMID:39059093 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Diosgenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; Diosgenin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:24001619 PMID:35305976 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of LDHA protein] CTD PMID:39059093 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lipc lipase C, hepatic type increases activity EXP Diosgenin results in increased activity of LIPC protein CTD PMID:20149787 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases lipidation 		EXP
ISO 		[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]
3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; [alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased lipidation of MAP1LC3B protein] 		CTD PMID:35149085 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 decreases expression ISO Diosgenin results in decreased expression of MESP1 mRNA; Diosgenin results in decreased expression of MESP1 protein CTD PMID:34806916 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:143,147,671...143,149,189 		JBrowse link
G Mest mesoderm specific transcript multiple interactions
decreases expression 		ISO Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
Diosgenin results in decreased expression of MEST mRNA 		CTD PMID:26408789 NCBI chr 4:60,321,814...60,332,288
Ensembl chr 4:60,316,102...60,333,509 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN1 protein] CTD PMID:35149085 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of MFN2 protein] CTD PMID:35149085 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression 		EXP Diosgenin results in increased activity of MMP2 protein
Diosgenin results in increased expression of MMP2 mRNA 		CTD PMID:21814480 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity 		ISO
EXP 		Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
Diosgenin results in decreased expression of MMP9 mRNA
Diosgenin results in decreased activity of MMP9 protein 		CTD PMID:16331273 PMID:21814480 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO
EXP 		3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of MTOR mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased phosphorylation of MTOR protein]; Diosgenin inhibits the reaction [MTOR protein promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FASN protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of HIF1A protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA protein]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MTOR mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased phosphorylation of MTOR protein] 		CTD PMID:35149085 PMID:39536891 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:16331273 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:16331273 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:16331273 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 mRNA]; Diosgenin affects the reaction [Dietary Fats affects the expression of NR1H4 protein] CTD PMID:33383043 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diosgenin results in increased activity of NR1I2 protein CTD PMID:15611112 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in increased degradation of NR3C1 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL6 protein]]
Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of NR3C1 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of CDH5 protein]]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of PECAM1 protein]]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]] 		CTD PMID:39059093 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of PECAM1 protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in decreased expression of PECAM1 protein]] CTD PMID:39059093 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression
multiple interactions 		ISO Diosgenin results in increased expression of PIK3R1 mRNA
[Diosgenin co-treated with Ecdysterone] results in increased expression of PIK3R1 mRNA 		CTD PMID:39395682 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases response to substance
decreases expression
multiple interactions 		ISO Diosgenin results in increased expression of PPARG protein
Diosgenin results in increased expression of PPARG mRNA
PPARG protein results in decreased susceptibility to Diosgenin
Diosgenin results in decreased expression of PPARG mRNA
[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA] 		CTD PMID:24001619 PMID:26408789 PMID:32347045 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:16331273 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of RELA protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of RELA protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA] 		CTD PMID:16331273 PMID:35305976 PMID:39536891 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 multiple interactions EXP Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of RHBDF2 protein] CTD PMID:35305976 NCBI chr10:102,331,991...102,359,117
Ensembl chr10:102,331,991...102,359,117 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:35149085 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein] CTD PMID:26408789 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of SCARB1 protein] CTD PMID:33383043 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO Diosgenin inhibits the reaction [alpha-Chlorohydrin results in decreased phosphorylation of STK11 protein] CTD PMID:35149085 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
G Tagln transgelin multiple interactions EXP
ISO 		Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]
Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]; NR3C1 promotes the reaction [Diosgenin inhibits the reaction [Arsenic Trioxide results in increased expression of TAGLN protein]] 		CTD PMID:39059093 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity 		ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Diosgenin inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Diosgenin results in decreased activity of TNF protein 		CTD PMID:16331273 PMID:35305976 PMID:39536891 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases activity 		ISO Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
Diosgenin results in decreased activity of TNFSF11 protein 		CTD PMID:16331273 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein]; [Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein CTD PMID:35149085 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP 		Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA mRNA]; Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA mRNA]]; MTOR protein inhibits the reaction [Diosgenin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of VEGFA protein]]
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA]; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] 		CTD PMID:16331273 PMID:39536891 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO Diosgenin results in decreased expression of WNT10B mRNA CTD PMID:26408789 NCBI chr 7:131,801,046...131,806,850
Ensembl chr 7:131,801,046...131,806,850 		JBrowse link
solasodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO solasodine results in decreased phosphorylation of AKT1 protein CTD PMID:28283413 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO solasodine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bsg basigin decreases expression ISO solasodine results in decreased expression of BSG mRNA CTD PMID:28283413 NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP3 protein CTD PMID:37121296 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP7 protein CTD PMID:37121296 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of CASP9 protein CTD PMID:37121296 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions 		ISO solasodine results in increased expression of CDH1 protein
CLDN2 protein inhibits the reaction [solasodine results in increased expression of CDH1 protein] 		CTD PMID:37121296 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions 		ISO solasodine results in decreased expression of CDH2 mRNA; solasodine results in decreased expression of CDH2 protein
CLDN2 protein inhibits the reaction [solasodine results in decreased expression of CDH2 protein] 		CTD PMID:37121296 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression 		ISO acadesine promotes the reaction [solasodine results in decreased expression of CLDN2 protein]; CLDN2 protein inhibits the reaction [solasodine results in decreased expression of CDH2 protein]; CLDN2 protein inhibits the reaction [solasodine results in decreased expression of VIM protein]; CLDN2 protein inhibits the reaction [solasodine results in increased expression of CDH1 protein]
solasodine results in decreased expression of CLDN2 mRNA; solasodine results in decreased expression of CLDN2 protein 		CTD PMID:37121296 NCBI chr  X:108,248,383...108,258,847
Ensembl chr  X:108,237,676...108,262,377 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO solasodine results in decreased expression of GPX4 protein CTD PMID:37121296 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL1B protein] CTD PMID:36084726 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:36084726 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:36084726 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Mir21 microRNA 21 decreases expression ISO solasodine results in decreased expression of MIR21; solasodine results in decreased expression of MIR21 mRNA CTD PMID:28283413 PMID:37121296 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO solasodine results in decreased expression of MMP2 mRNA CTD PMID:28283413 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO solasodine results in decreased expression of MMP9 mRNA CTD PMID:28283413 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO solasodine results in increased cleavage of and results in decreased expression of PARP1 protein CTD PMID:37121296 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO solasodine results in increased phosphorylation of PRKAA1 protein CTD PMID:37121296 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO solasodine results in increased expression of RECK mRNA CTD PMID:28283413 NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases localization ISO solasodine results in decreased localization of RELA protein CTD PMID:37121296 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO solasodine results in decreased expression of RHOA protein CTD PMID:37121296 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO solasodine results in decreased expression of SLC7A11 protein CTD PMID:37121296 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO solasodine results in decreased phosphorylation of STAT3 protein CTD PMID:37121296 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO solasodine results in increased expression of TIMP1 mRNA CTD PMID:28283413 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO solasodine results in increased expression of TIMP2 mRNA CTD PMID:28283413 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP solasodine inhibits the reaction [Ovalbumin results in increased secretion of TNF protein] CTD PMID:36084726 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vim vimentin decreases expression
multiple interactions 		ISO solasodine results in decreased expression of VIM mRNA; solasodine results in decreased expression of VIM protein
CLDN2 protein inhibits the reaction [solasodine results in decreased expression of VIM protein] 		CTD PMID:37121296 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      group 20774
        polyatomic entity 20745
          molecule 20540
            cyclic compound 20415
              organic cyclic compound 20390
                organic polycyclic compound 17588
                  sapogenin 126
                    (25R)-5beta-spirostan-1beta,3alpha-diol 0
                    (25R)-5beta-spirostan-3beta-ol 0
                    (25S)-5beta-spirostan-3beta-ol 0
                    4-epihederagenin 0
                    barringtogenol C 0
                    cycloastragenol 22
                    diosgenin 73
                    esculeogenin A 0
                    gypsogenin 0
                    hederagenin 0
                    nuatigenin 0
                    pennogenin 0
                    protopanaxadiol + 26
                    protopanaxatriol 0
                    solasodine 27
                    spathodic acid 0
                    tigogenin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      p-block molecular entity 20796
                        carbon group molecular entity 20724
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic polycyclic compound 17588
                                  sapogenin 126
                                    (25R)-5beta-spirostan-1beta,3alpha-diol 0
                                    (25R)-5beta-spirostan-3beta-ol 0
                                    (25S)-5beta-spirostan-3beta-ol 0
                                    4-epihederagenin 0
                                    barringtogenol C 0
                                    cycloastragenol 22
                                    diosgenin 73
                                    esculeogenin A 0
                                    gypsogenin 0
                                    hederagenin 0
                                    nuatigenin 0
                                    pennogenin 0
                                    protopanaxadiol + 26
                                    protopanaxatriol 0
                                    solasodine 27
                                    spathodic acid 0
                                    tigogenin 0
paths to the root