salicylates - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	salicylates	go back to main search page
Accession:	CHEBI:26596	browse the term
Definition:	Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.
Synonyms:	xref_mesh:	MESH:D012459
	xref:	PMID:22866967

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Rat (712) Mouse (716) Human (736) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (712)

salicylates

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

increases expression

Salicylates results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

multiple interactions

Salicylates inhibits the reaction [zomepirac glucuronide binds to ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

apolipoprotein A1

increases expression

Salicylates results in increased expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

amyloid beta precursor protein

multiple interactions

Salicylates inhibits the reaction [APP protein results in increased uptake of Calcium]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

estrogen receptor 1

multiple interactions

Salicylates analog binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Salicylates analog binds to and results in decreased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

interleukin 1 beta

multiple interactions

Salicylates inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Salicylates inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

matrix metallopeptidase 7

decreases expression

Salicylates results in decreased expression of MMP7 protein

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

nuclear factor kappa B subunit 1

multiple interactions

Salicylates inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

paraoxonase 1

increases expression
increases activity

Salicylates results in increased expression of PON1 mRNA
Salicylates results in increased activity of PON1 protein

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Salicylates inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 12

multiple interactions

Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22, member 19

multiple interactions

Salicylates inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A]

NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538

G

solute carrier family 22 member 20

multiple interactions

Salicylates inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]

NCBI chr 1:203,257,374...203,273,854
Ensembl chr 1:203,257,374...203,273,822

G

solute carrier family 22 member 6

multiple interactions

Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

tumor necrosis factor

multiple interactions

Salicylates inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Salicylates inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

2-acetyloxy-4-(trifluoromethyl)benzoic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFKB inhibitor alpha

increases expression
multiple interactions

triflusal results in increased expression of NFKBIA protein
triflusal promotes the reaction [RELA protein binds to NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

natriuretic peptide A

multiple interactions

triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

prostaglandin-endoperoxide synthase 2

multiple interactions

triflusal inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein]
triflusal inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

triflusal promotes the reaction [RELA protein binds to NFKBIA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

acetylsalicylic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression
multiple interactions
affects expression
increases expression

Aspirin results in decreased expression of ABCA1 mRNA
Aspirin affects the expression of and affects the activity of ABCA1 protein; PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]
Aspirin results in increased expression of ABCA1 mRNA; Aspirin results in increased expression of ABCA1 protein

PMID:15037193 PMID:20137092 PMID:21088444

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions
increases activity

Aspirin results in increased expression of ABCB1 mRNA; Aspirin results in increased expression of ABCB1 protein
[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel
Aspirin results in increased activity of ABCB1 protein

PMID:19840843 PMID:21900887

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases activity

Aspirin results in increased activity of ABCB1B protein

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

increases expression

Aspirin results in increased expression of ABCC1 mRNA; Aspirin results in increased expression of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 4

increases expression

Aspirin results in increased expression of ABCC4 mRNA; Aspirin results in increased expression of ABCC4 protein

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

increases expression

Aspirin results in increased expression of ABCC5 mRNA; Aspirin results in increased expression of ABCC5 protein

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

acetyl-CoA carboxylase alpha

increases expression
multiple interactions

Aspirin results in increased expression of ACACA protein modified form
CES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase medium chain

increases expression

Aspirin results in increased expression of ACADM mRNA; Aspirin results in increased expression of ACADM protein

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 3

increases expression

Aspirin results in increased expression of ACAP3 mRNA

NCBI chr 5:166,501,150...166,515,477
Ensembl chr 5:166,500,781...166,515,481

G

angiotensin I converting enzyme

affects response to substance

ACE polymorphism affects the susceptibility to Aspirin

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

apoptotic chromatin condensation inducer 1

decreases expression
increases expression

Aspirin results in decreased expression of ACIN1 mRNA
Aspirin results in increased expression of ACIN1 mRNA

PMID:11906190 PMID:15928584

NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001

G

actin, beta

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTB protein]

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin related protein 3

decreases expression

Aspirin results in decreased expression of ACTR3 mRNA

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

ADAM metallopeptidase domain 33

affects response to substance

ADAM33 SNP affects the susceptibility to Aspirin

NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

Aspirin results in decreased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

adenosine kinase

affects binding

Aspirin binds to ADK protein

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adenosine A1 receptor

affects response to substance

ADORA1 polymorphism affects the susceptibility to Aspirin

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

affects response to substance

ADORA2A polymorphism affects the susceptibility to Aspirin

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A3 receptor

affects response to substance

ADORA3 protein affects the susceptibility to Aspirin

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

adrenoceptor beta 2

affects response to substance

ADRB2 polymorphism affects the susceptibility to Aspirin; ADRB2 SNP affects the susceptibility to Aspirin

PMID:18159608 PMID:18379861

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

angiotensinogen

affects activity

Aspirin affects the activity of AGT protein

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions

Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

aryl hydrocarbon receptor

increases expression
multiple interactions

Aspirin results in increased expression of AHR mRNA
AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of APOA1 mRNA]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

allograft inflammatory factor 1-like

increases expression

Aspirin results in increased expression of AIF1L mRNA

NCBI chr 3:15,229,476...15,254,033
Ensembl chr 3:15,229,524...15,254,023

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

decreases expression

Aspirin results in decreased expression of AIMP2 mRNA

NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769

G

aldo-keto reductase family 1, member C1

decreases activity

Aspirin results in decreased activity of AKR1C1 protein

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

decreases activity

Aspirin results in decreased activity of AKR1C2 protein

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

decreases activity

Aspirin results in decreased activity of AKR1C3 protein

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

multiple interactions
increases expression
increases activity

[troglitazone co-treated with Aspirin] results in decreased expression of AKT1 protein; [troglitazone co-treated with Aspirin] results in decreased expression of AKT1 protein modified form; Aspirin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
Aspirin results in increased expression of AKT1 mRNA
Aspirin results in increased activity of AKT1 protein

PMID:19908241 PMID:20116423 PMID:20457246 PMID:21617849

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

increases expression

Aspirin results in increased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

5'-aminolevulinate synthase 1

increases expression

Aspirin results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

multiple interactions
decreases secretion

ALB protein binds to and affects the transport of Aspirin; Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]; Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; Aspirin inhibits the reaction [zomepirac glucuronide binds to ALB protein]; Aspirin promotes the reaction [menadione epoxide analog binds to ALB protein]
Aspirin results in decreased secretion of ALB protein

PMID:1981713 PMID:8831264 PMID:17303692 PMID:25499135

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

affects binding

Aspirin binds to ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

decreases expression

Aspirin results in decreased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

angiopoietin-like 3

decreases expression

Aspirin results in decreased expression of ANGPTL3 mRNA

NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957

G

anoctamin 9

increases expression

Aspirin results in increased expression of ANO9 mRNA

NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900

G

alanyl aminopeptidase, membrane

increases activity
increases expression

Aspirin results in increased activity of ANPEP protein
Aspirin results in increased expression of ANPEP mRNA; Aspirin results in increased expression of ANPEP protein

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

adaptor related protein complex 2 subunit beta 1

decreases expression

Aspirin results in decreased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

apoptotic peptidase activating factor 1

increases response to substance
increases expression

APAF1 results in increased susceptibility to Aspirin
Aspirin results in increased expression of APAF1 mRNA

PMID:11228543 PMID:20457246

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apolipoprotein A1

multiple interactions
increases expression
increases activity

AHR mutant form inhibits the reaction [Aspirin results in increased expression of APOA1 mRNA]; Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]]
Aspirin results in increased activity of APOA1 mRNA

PMID:9399670 PMID:18519978 PMID:21088444

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein C1

multiple interactions

Aspirin inhibits the reaction [APOC1 results in increased abundance of Triglycerides]

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

apolipoprotein E

affects response to substance
multiple interactions

APOE polymorphism affects the susceptibility to Aspirin
Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]
Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]

PMID:15084783 PMID:20530721

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

multiple interactions

Aspirin inhibits the reaction [[Benzo(a)pyrene affects the expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

adenine phosphoribosyl transferase

decreases expression

Aspirin results in decreased expression of APRT mRNA

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

ADP-ribosylation factor like GTPase 6 interacting protein 5

increases expression

Aspirin results in increased expression of ARL6IP5 mRNA

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

G

cAMP-regulated phosphoprotein 19

increases expression

Aspirin results in increased expression of ARPP19 mRNA

NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452
Ensembl chr 8:75,779,523...75,802,452

G

acid sensing ion channel subunit 1

decreases expression

Aspirin results in decreased expression of ASIC1 mRNA

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

G

acid sensing ion channel subunit 2

decreases expression

Aspirin results in decreased expression of ASIC2 mRNA

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

G

acid sensing ion channel subunit 3

decreases expression
decreases activity

Aspirin results in decreased expression of ASIC3 mRNA
Aspirin results in decreased activity of ASIC3 protein

NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643

G

argininosuccinate lyase

decreases expression

Aspirin results in decreased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

astrotactin 2

increases expression

Aspirin results in increased expression of ASTN2 mRNA

NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273

G

activating transcription factor 4

decreases expression

Aspirin results in decreased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATM serine/threonine kinase

increases expression

Aspirin results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

increases expression

Aspirin results in increased expression of ATP2A1 mRNA

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

ATP synthase F1 subunit epsilon

increases expression

Aspirin results in increased expression of ATP5F1E mRNA

NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450

G

ATPase H+ transporting V0 subunit B

decreases expression

Aspirin results in decreased expression of ATP6V0B mRNA

NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401

G

ATPase H+ transporting V0 subunit D1

decreases expression

Aspirin results in decreased expression of ATP6V0D1 mRNA

NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450

G

ATR serine/threonine kinase

decreases expression

Aspirin results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

all-trans retinoic acid-induced differentiation factor

decreases expression

Aspirin results in decreased expression of ATRAID mRNA

NCBI chr 6:25,315,236...25,319,821

G

aurora kinase A

increases expression

Aspirin results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

beta-2 microglobulin

increases expression

Aspirin results in increased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

beta-1,4-galactosyltransferase 1

increases expression

Aspirin results in increased expression of B4GALT1 mRNA

NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461

G

BCL2-associated agonist of cell death

decreases expression

Aspirin results in decreased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

increases expression

Aspirin results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BRCA1 associated deubiquitinase 1

decreases expression

Aspirin results in decreased expression of BAP1 mRNA

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
increases localization
decreases expression

Aspirin promotes the reaction [Fluorouracil results in increased expression of BAX protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein]; Fluorouracil promotes the reaction [Aspirin results in increased expression of BAX protein]
Aspirin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Bee Venoms inhibits the reaction [Aspirin results in increased expression of BAX protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein]
Aspirin results in decreased expression of BAX mRNA; Aspirin results in decreased expression of BAX protein

PMID:11228543 PMID:11532860 PMID:15976387 PMID:15986848 PMID:16880202 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

decreases expression

Aspirin results in decreased expression of BAZ1B mRNA

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

Bcl-2 binding component 3

increases expression
increases response to substance

Aspirin results in increased expression of BBC3 mRNA
BBC3 results in increased susceptibility to Aspirin

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

bublin coiled coil protein

increases expression

Aspirin results in increased expression of BBLN mRNA

NCBI chr 3:15,674,577...15,677,322
Ensembl chr 3:15,674,580...15,677,374

G

basal body orientation factor 1

increases expression

Aspirin results in increased expression of BBOF1 mRNA

NCBI chr 6:104,055,246...104,081,036
Ensembl chr 6:104,055,241...104,082,071

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BCAR3 adaptor protein, NSP family member

increases expression

Aspirin results in increased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

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BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

Aspirin inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]
Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
Aspirin results in decreased expression of BCL2 mRNA; Aspirin results in decreased expression of BCL2 protein
Aspirin inhibits the reaction [Azoxymethane results in increased expression of BCL2 mRNA]
Aspirin results in increased expression of BCL2 mRNA; Aspirin results in increased expression of BCL2 protein

PMID:12490308 PMID:14636445 PMID:15976387 PMID:16199534 PMID:17342322 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

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Bcl2-like 1

decreases expression
increases expression

Aspirin results in decreased expression of BCL2L1 protein
Aspirin results in increased expression of BCL2L1 mRNA

PMID:17342322 PMID:20457246 PMID:20886344

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

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Bcl2-like 11

increases expression

Aspirin results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

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brain-derived neurotrophic factor

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF mRNA alternative form]; Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF protein]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased methylation of BDNF promoter alternative form]

PMID:34979192 PMID:37364758

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BH3 interacting domain death agonist

multiple interactions
increases cleavage

[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of BID protein; CASP8 affects the reaction [Aspirin results in increased cleavage of BID protein]

PMID:15976387 PMID:18483385

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

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bridging integrator 1

increases expression

Aspirin results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

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baculoviral IAP repeat-containing 5

multiple interactions
increases expression
decreases expression

[Aspirin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein; Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter]; epoxomicin inhibits the reaction [Aspirin results in decreased expression of BIRC5 protein]
Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein]
Aspirin results in increased expression of BIRC5 mRNA
Aspirin results in decreased expression of BIRC5 mRNA; Aspirin results in decreased expression of BIRC5 protein

PMID:11906190 PMID:17342322 PMID:17848598 PMID:18483385 PMID:25449198

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

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bleomycin hydrolase

decreases expression

Aspirin results in decreased expression of BLMH mRNA

NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212

G

Bcl2 modifying factor

increases expression

Aspirin results in increased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

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bone morphogenetic protein 6

increases expression

Aspirin results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

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BCL2 interacting protein 3 like

increases expression

Aspirin results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

BRCA1, DNA repair associated

decreases expression

Aspirin results in decreased expression of BRCA1 mRNA

PMID:20457246 PMID:20514442

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

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bromodomain containing 4

increases expression

Aspirin results in increased expression of BRD4 mRNA

NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539

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BTG anti-proliferation factor 1

increases expression

Aspirin results in increased expression of BTG1 mRNA

PMID:12800193 PMID:15928584

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

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basic leucine zipper and W2 domains 1

increases expression

Aspirin results in increased expression of BZW1 mRNA

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

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calcium voltage-gated channel auxiliary subunit gamma 1

decreases expression

Aspirin results in decreased expression of CACNG1 mRNA

NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783

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calcium voltage-gated channel auxiliary subunit gamma 6

affects response to substance

CACNG6 polymorphism affects the susceptibility to Aspirin

NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341

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calcitonin-related polypeptide alpha

decreases expression

Aspirin results in decreased expression of CALCA mRNA

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calmodulin 1

multiple interactions

Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]]

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin 3

increases expression

Aspirin results in increased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

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calnexin

decreases expression

Aspirin results in decreased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

calpain 1

increases expression

Aspirin results in increased expression of CAPN1 mRNA

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

increases expression

Aspirin results in increased expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

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calpain, small subunit 1

decreases expression

Aspirin results in decreased expression of CAPNS1 mRNA

NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795

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calcyphosine-like

increases expression

Aspirin results in increased expression of CAPSL mRNA

NCBI chr 2:58,394,995...58,425,527
Ensembl chr 2:58,411,424...58,424,980

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capping actin protein of muscle Z-line subunit alpha 1

increases expression

Aspirin results in increased expression of CAPZA1 mRNA

NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480

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capping actin protein of muscle Z-line subunit alpha 2

increases expression

Aspirin results in increased expression of CAPZA2 mRNA

NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864

G

caspase 3

increases activity
multiple interactions
increases expression
decreases expression

Aspirin results in increased activity of CASP3 protein
Aspirin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
Bee Venoms inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein]
Aspirin results in increased expression of CASP3 mRNA; Aspirin results in increased expression of CASP3 protein
[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; [troglitazone co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Methotrexate results in decreased expression of CASP3 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]
Aspirin results in decreased expression of CASP3 mRNA

PMID:11034327 PMID:11228543 PMID:11532860 PMID:12490308 PMID:14753751 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 6

multiple interactions

Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP6 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP6 protein

PMID:15481331 PMID:17644113

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

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caspase 7

multiple interactions

Aspirin results in increased cleavage of and results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

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caspase 8

multiple interactions
increases expression
increases activity

[Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of CASP8 protein; Aspirin results in increased cleavage of and results in increased activity of CASP8 protein; CASP8 affects the reaction [Aspirin results in increased cleavage of BID protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein]
Aspirin results in increased expression of CASP8 mRNA
Aspirin results in increased activity of CASP8 protein

PMID:11034327 PMID:15481331 PMID:15976387 PMID:16199534 PMID:18483385 More...

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

multiple interactions
increases activity

[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP9 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP9 protein; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]
Aspirin results in increased activity of CASP9 protein

PMID:11034327 PMID:14753751 PMID:15481331 PMID:16199534 PMID:16880202 More...

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

decreases activity
increases expression

Aspirin results in decreased activity of CAT; Aspirin results in decreased activity of CAT protein
Aspirin results in increased expression of CAT protein

PMID:6845354 PMID:9212780 PMID:10528994 PMID:17147060 PMID:17274466

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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caveolin 1

decreases expression

Aspirin results in decreased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

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C-C motif chemokine ligand 19

increases expression

Aspirin results in increased expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

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C-C motif chemokine ligand 2

multiple interactions

Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Aspirin inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [TNF results in increased secretion of CCL2 protein]
Aspirin inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA]

PMID:15136050 PMID:16600694 PMID:24211328 PMID:35574720

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

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C-C motif chemokine ligand 3

decreases expression

Aspirin results in decreased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

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cellular communication network factor 2

multiple interactions

Aspirin inhibits the reaction [Glucose results in increased expression of CCN2 mRNA]; Aspirin inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

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cyclin A2

multiple interactions

Aspirin inhibits the reaction [Methotrexate results in increased expression of CCNA2 protein]

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

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cyclin B1

multiple interactions
increases expression

Aspirin inhibits the reaction [troglitazone results in decreased expression of CCNB1 protein]
Aspirin results in increased expression of CCNB1 mRNA

PMID:11906190 PMID:19908241

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

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cyclin D1

multiple interactions
decreases expression
increases expression

Aspirin inhibits the reaction [Smoke analog results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein]
Aspirin results in decreased expression of CCND1 mRNA; Aspirin results in decreased expression of CCND1 protein
Aspirin results in increased expression of CCND1 mRNA

PMID:11313997 PMID:11593435 PMID:12800193 PMID:15489888 PMID:16878161 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

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cyclin D3

multiple interactions
decreases expression

Aspirin promotes the reaction [troglitazone results in decreased expression of CCND3 protein]; troglitazone promotes the reaction [Aspirin results in decreased expression of CCND3 protein]
Aspirin results in decreased expression of CCND3 mRNA; Aspirin results in decreased expression of CCND3 protein

PMID:14976132 PMID:19908241

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

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cyclin E1

affects expression
decreases expression

Aspirin affects the expression of CCNE1 mRNA
Aspirin results in decreased expression of CCNE1 mRNA

PMID:12800193 PMID:20457246

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin J

increases expression

Aspirin results in increased expression of CCNJ mRNA

NCBI chr 1:239,659,588...239,677,367

G

C-C motif chemokine receptor 3

affects response to substance
increases expression

CCR3 gene SNP affects the susceptibility to Aspirin; CCR3 SNP affects the susceptibility to Aspirin
Aspirin results in increased expression of CCR3 mRNA

PMID:18379861 PMID:20022477 PMID:20485159

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

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CD151 molecule (Raph blood group)

decreases expression

Aspirin results in decreased expression of CD151 protein

NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753

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CD274 molecule

increases expression

Aspirin results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

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CD36 molecule

decreases expression
increases expression

Aspirin results in decreased expression of CD36 protein
Aspirin results in increased expression of CD36 mRNA

PMID:15140583 PMID:15381054 PMID:18222077

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

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CD40 ligand

decreases expression

Aspirin results in decreased expression of CD40LG protein

PMID:15140583 PMID:15381054

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

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CD44 molecule

decreases expression
multiple interactions

Aspirin results in decreased expression of CD44 protein alternative form
Aspirin results in decreased expression of CD44 mRNA
CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form]

PMID:12800193 PMID:16878161

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

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CD55 molecule (Cromer blood group)

affects expression

Aspirin affects the expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

Cd6 molecule

decreases expression

Aspirin results in decreased expression of CD6 mRNA

NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634

G

CD74 molecule

decreases expression

Aspirin results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

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CD8 subunit alpha

decreases expression

Aspirin results in decreased expression of CD8A mRNA

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

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cell division cycle 25A

decreases expression

Aspirin results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

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cell division cycle 37, HSP90 cochaperone

decreases expression

Aspirin results in decreased expression of CDC37 mRNA

NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809

G

cell division cycle 42

decreases expression

Aspirin results in decreased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

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cadherin 1

affects methylation

Aspirin affects the methylation of CDH1 promoter

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

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cyclin-dependent kinase 19

increases expression

Aspirin results in increased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628

G

cyclin dependent kinase 2

decreases expression
multiple interactions

Aspirin results in decreased expression of CDK2 mRNA; Aspirin results in decreased expression of CDK2 protein
troglitazone promotes the reaction [Aspirin results in decreased expression of CDK2 protein]

PMID:19908241 PMID:20457246

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

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cyclin-dependent kinase 4

decreases expression

Aspirin results in decreased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

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cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression
increases expression
affects expression
decreases activity

Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]; Aspirin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]]; wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein]
Aspirin results in decreased expression of CDKN1A mRNA
Aspirin results in increased expression of CDKN1A mRNA; Aspirin results in increased expression of CDKN1A protein
Aspirin affects the expression of CDKN1A protein
Aspirin results in decreased activity of CDKN1A protein

PMID:14976132 PMID:15190207 PMID:19212664 PMID:19908241 PMID:20404564 More...

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

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cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

[troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein
Aspirin results in increased expression of CDKN1B protein

PMID:16880202 PMID:19908241

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

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CDP-diacylglycerol synthase 1

increases expression

Aspirin results in increased expression of CDS1 mRNA

NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681

G

CCAAT/enhancer binding protein beta

multiple interactions

Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein S

increases expression

Aspirin results in increased expression of CENPS mRNA

NCBI chr 5:159,563,917...159,573,534

G

centrosomal protein 68

affects response to substance

CEP68 SNP affects the susceptibility to Aspirin

NCBI chr14:94,447,973...94,470,533
Ensembl chr14:94,449,055...94,470,517

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carboxylesterase 1D

multiple interactions

CES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form]; CES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2C

increases hydrolysis

CES2C protein results in increased hydrolysis of Aspirin

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790

G

carboxylesterase 2E

increases hydrolysis

CES2E protein results in increased hydrolysis of Aspirin

NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856

G

carboxylesterase 2H

affects hydrolysis
increases hydrolysis

CES2 protein affects the hydrolysis of Aspirin
CES2 protein results in increased hydrolysis of Aspirin

PMID:9300133 PMID:18983829

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

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CASP8 and FADD-like apoptosis regulator

increases expression
multiple interactions

Aspirin results in increased expression of CFLAR mRNA
Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein]

PMID:20457246 PMID:25449198

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

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chromodomain helicase DNA binding protein 2

increases expression

Aspirin results in increased expression of CHD2 mRNA

NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502

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checkpoint kinase 2

increases expression

Aspirin results in increased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

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charged multivesicular body protein 1A

decreases expression

Aspirin results in decreased expression of CHMP1A mRNA

NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436

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component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
decreases phosphorylation

Aspirin inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Aspirin results in decreased phosphorylation of CHUK protein

PMID:15489888 PMID:16310244

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

CDC28 protein kinase regulatory subunit 1B

increases expression

Aspirin results in increased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

claudin 7

increases expression

Aspirin results in increased expression of CLDN7 mRNA

NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171

G

CAP-GLY domain containing linker protein 3

increases expression

Aspirin results in increased expression of CLIP3 mRNA

NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184

G

CDC-like kinase 2

decreases expression

Aspirin results in decreased expression of CLK2 mRNA

NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985

G

CDC-like kinase 3

decreases expression

Aspirin results in decreased expression of CLK3 mRNA

NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181

G

collagen type XXVI alpha 1 chain

affects response to substance

COL26A1 polymorphism affects the susceptibility to Aspirin

NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556

G

collagen type III alpha 1 chain

decreases expression

Aspirin results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type VII alpha 1 chain

decreases expression

Aspirin results in decreased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

copine 1

increases expression

Aspirin results in increased expression of CPNE1 mRNA

NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636

G

carnitine palmitoyltransferase 1A

increases expression

Aspirin results in increased expression of CPT1A mRNA; Aspirin results in increased expression of CPT1A protein

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

calcium release activated channel regulator 2B

increases expression

Aspirin results in increased expression of CRACR2B mRNA

NCBI chr 1:196,558,407...196,563,961
Ensembl chr 1:196,558,588...196,563,771

G

CREB binding protein

increases expression

Aspirin results in increased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

colony stimulating factor 3 receptor

decreases expression

Aspirin results in decreased expression of CSF3R mRNA

NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881

G

casein kinase 2 alpha 1

increases expression
decreases expression

Aspirin results in increased expression of CSNK2A1 mRNA
Aspirin results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

cystatin A

increases expression

Aspirin results in increased expression of CSTA mRNA

PMID:15456535 PMID:15928584

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

catenin beta 1

increases phosphorylation
decreases localization
multiple interactions
increases ubiquitination

Aspirin results in increased phosphorylation of CTNNB1 protein
Aspirin results in decreased localization of CTNNB1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Aspirin results in increased ubiquitination of CTNNB1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CMET protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein]; Lithium Chloride inhibits the reaction [Aspirin results in increased phosphorylation of CTNNB1 protein]

PMID:12813129 PMID:16878161 PMID:17357503

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

decreases expression

Aspirin results in decreased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

C-X3-C motif chemokine ligand 1

multiple interactions
decreases expression

Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein]
Aspirin results in decreased expression of CX3CL1 mRNA; Aspirin results in decreased expression of CX3CL1 protein

PMID:19493461 PMID:19997773

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA]

PMID:14742690 PMID:17303692

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 3

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA]

PMID:14742690 PMID:17303692

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

increases expression

Aspirin results in increased expression of CXCL5 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

cytochrome c-1

increases expression

Aspirin results in increased expression of CYC1 mRNA

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Aspirin results in increased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cysteinyl leukotriene receptor 1

increases expression
multiple interactions
affects response to substance

Aspirin results in increased expression of CYSLTR1 mRNA
Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]
CYSLTR1 gene SNP affects the susceptibility to Aspirin; CYSLTR1 SNP affects the susceptibility to Aspirin

PMID:16630147 PMID:17641958 PMID:18379861 PMID:19767084 PMID:20485159

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

cysteinyl leukotriene receptor 2

affects response to substance

CYSLTR2 gene SNP affects the susceptibility to Aspirin; CYSLTR2 polymorphism affects the susceptibility to Aspirin

PMID:15970796 PMID:20485159

NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136

G

death-associated protein

decreases expression

Aspirin results in decreased expression of DAP mRNA

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

DNA-damage inducible transcript 3

increases expression

Aspirin results in increased expression of DDIT3 mRNA

PMID:12800193 PMID:14976132

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 18

decreases expression

Aspirin results in decreased expression of DDX18 mRNA

NCBI chr13:32,729,697...32,743,161
Ensembl chr13:32,729,700...32,743,161

G

DEAD-box helicase 5

increases expression

Aspirin results in increased expression of DDX5 mRNA

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

defensin alpha 5

increases expression

Aspirin results in increased expression of DEFA5 mRNA

NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836

G

DEK proto-oncogene

increases expression

Aspirin results in increased expression of DEK mRNA

NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808

G

DENN domain containing 5A

increases expression

Aspirin results in increased expression of DENND5A mRNA

NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316

G

diablo, IAP-binding mitochondrial protein

decreases expression

Aspirin results in decreased expression of DIABLO protein

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dihydrolipoamide S-succinyltransferase

decreases expression

Aspirin results in decreased expression of DLST mRNA

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

DNA methyltransferase 1

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 protein]

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3A mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3A protein]

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3B mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3B protein]

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dual specificity phosphatase 1

affects expression

Aspirin affects the expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 5

affects expression

Aspirin affects the expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 6

increases expression

Aspirin results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

E2F transcription factor 1

multiple interactions
decreases expression

[troglitazone co-treated with Aspirin] results in decreased expression of E2F1 protein; Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter]
Aspirin results in decreased expression of E2F1 mRNA

PMID:17848598 PMID:19908241 PMID:20457246

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

endothelin receptor type B

multiple interactions

Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

eukaryotic translation elongation factor 1 alpha 1

increases expression

Aspirin results in increased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

epidermal growth factor receptor

increases expression

Aspirin results in increased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression

Aspirin results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 4

decreases expression

Aspirin results in decreased expression of EGR4 mRNA

NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

Aspirin results in decreased expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

euchromatic histone lysine methyltransferase 2

increases expression

Aspirin results in increased expression of EHMT2 mRNA

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 2 subunit beta

increases expression

Aspirin results in increased expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Aspirin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

E74 like ETS transcription factor 4

decreases expression

Aspirin results in decreased expression of ELF4 mRNA

NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200

G

ELOVL fatty acid elongase 5

increases expression
decreases expression

Aspirin results in increased expression of ELOVL5 mRNA
Aspirin results in decreased expression of ELOVL5 mRNA

PMID:11906190 PMID:15928584

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Aspirin results in decreased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 2

increases expression

Aspirin results in increased expression of ENTPD2 mRNA

NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866

G

ectonucleoside triphosphate diphosphohydrolase 4

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENTPD4 mRNA]

NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706

G

ependymin related 1

decreases expression

Aspirin results in decreased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

G

epoxide hydrolase 2

multiple interactions

Aspirin promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]]

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

erb-b2 receptor tyrosine kinase 2

decreases expression
increases expression

Aspirin results in decreased expression of ERBB2 mRNA; Aspirin results in decreased expression of ERBB2 protein
Aspirin results in increased expression of ERBB2 mRNA

PMID:19424877 PMID:20457246

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erbb2 interacting protein

increases expression

Aspirin results in increased expression of ERBIN mRNA

NCBI chr 2:34,926,962...35,028,440
Ensembl chr 2:34,928,863...35,027,852

G

ERCC excision repair 5, endonuclease

increases expression

Aspirin results in increased expression of ERCC5 mRNA

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

epiregulin

increases expression

Aspirin results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

ETS proto-oncogene 2, transcription factor

decreases expression

Aspirin results in decreased expression of ETS2 mRNA

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

ecotropic viral integration site 2B

increases expression

Aspirin results in increased expression of EVI2B mRNA

NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560

G

ezrin

decreases expression

Aspirin results in decreased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II, thrombin

affects cleavage
multiple interactions

Aspirin affects the cleavage of F2 protein
ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

decreases expression

Aspirin results in decreased expression of F2R protein

PMID:15140583 PMID:15381054

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

Fas cell surface death receptor

affects expression
multiple interactions
increases expression

Aspirin affects the expression of FAS protein
Aspirin inhibits the reaction [Methotrexate results in increased expression of FAS protein]
Aspirin results in increased expression of FAS mRNA
Aspirin inhibits the reaction [Azoxymethane results in increased expression of FAS mRNA]

PMID:15200494 PMID:20043115 PMID:20457246 PMID:23799623

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

Aspirin inhibits the reaction [Azoxymethane results in increased expression of FASLG mRNA]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FAT atypical cadherin 3

increases expression

Aspirin results in increased expression of FAT3 mRNA

NCBI chr 8:12,691,470...13,274,336
Ensembl chr 8:12,694,019...13,273,135

G

F-box and leucine-rich repeat protein 3

increases expression

Aspirin results in increased expression of FBXL3 mRNA

NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867

G

F-box protein 11

increases expression

Aspirin results in increased expression of FBXO11 mRNA

NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662

G

Fc epsilon receptor Ia

affects response to substance
multiple interactions

FCER1A gene SNP affects the susceptibility to Aspirin; FCER1A polymorphism affects the susceptibility to Aspirin
Aspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]

PMID:17125826 PMID:19767084 PMID:20485159

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

Fc epsilon receptor Ig

decreases expression
affects response to substance

Aspirin results in decreased expression of FCER1G mRNA
FCER1G SNP affects the susceptibility to Aspirin

PMID:15928584 PMID:18534082 PMID:18595682

NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443

G

farnesyl diphosphate farnesyl transferase 1

increases expression

Aspirin results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

FER tyrosine kinase

decreases expression

Aspirin results in decreased expression of FER mRNA

NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451

G

fibrinogen alpha chain

decreases secretion
multiple interactions

Aspirin results in decreased secretion of FGA protein
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGA protein]; Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein]

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

multiple interactions
decreases secretion

Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]; Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGB protein]
Aspirin results in decreased secretion of FGB protein

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibrinogen gamma chain

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGG protein]; Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein]

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

Aspirin results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

FLII, actin remodeling protein

decreases expression

Aspirin results in decreased expression of FLII mRNA

NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970

G

flotillin 2

decreases expression

Aspirin results in decreased expression of FLOT2 mRNA

NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756

G

fibronectin 1

multiple interactions

Aspirin inhibits the reaction [Streptozocin results in increased expression of FN1]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression

Aspirin results in increased expression of FOS mRNA
Aspirin results in decreased expression of FOS mRNA

PMID:12800193 PMID:20457246

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Aspirin results in decreased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter]
Aspirin results in decreased expression of FOSL1 mRNA; Aspirin results in decreased expression of FOSL1 protein
Aspirin results in increased expression of FOSL1 mRNA

PMID:12800193 PMID:16893520 PMID:21721879

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

increases expression

Aspirin results in increased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

formyl peptide receptor 1

decreases expression

Aspirin results in decreased expression of FPR1 mRNA

NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559

G

formyl peptide receptor 2

increases expression
multiple interactions

Aspirin results in increased expression of FPR2
[Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2

NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019

G

fibrous sheath interacting protein 1

affects response to substance

FSIP1 SNP affects the susceptibility to Aspirin

NCBI chr 3:105,074,584...105,217,180
Ensembl chr 3:105,068,543...105,217,167

G

follistatin

affects expression

Aspirin affects the expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

furin (paired basic amino acid cleaving enzyme)

decreases expression

Aspirin results in decreased expression of FURIN mRNA

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

FMR1 autosomal homolog 2

decreases expression

Aspirin results in decreased expression of FXR2 mRNA

NCBI chr10:54,350,577...54,370,964
Ensembl chr10:54,350,131...54,370,964

G

G0/G1switch 2

increases expression

Aspirin results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose 6 phosphatase catalytic subunit 3

increases expression

Aspirin results in increased expression of G6PC3 mRNA

NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221

G

glucose-6-phosphate dehydrogenase

decreases response to substance
decreases activity

G6PD results in decreased susceptibility to Aspirin
Aspirin results in decreased activity of G6PD protein mutant form

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor-associated protein

decreases expression

Aspirin results in decreased expression of GABARAP mRNA

NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765

G

growth arrest and DNA-damage-inducible, alpha

decreases expression
increases expression

Aspirin results in decreased expression of GADD45A mRNA
Aspirin results in increased expression of GADD45A mRNA

PMID:12800193 PMID:20514442

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest specific 6

affects response to substance

GAS6 protein affects the susceptibility to Aspirin

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

gastrin

multiple interactions

[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of GAST protein

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

glutamine amidotransferase class 1 domain containing 3A

increases expression

Aspirin results in increased expression of GATD3 mRNA

NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885

G

growth differentiation factor 15

increases expression

Aspirin results in increased expression of GDF15 mRNA; Aspirin results in increased expression of GDF15 protein

PMID:14976132 PMID:15180942

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glial cell derived neurotrophic factor

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GDNF protein]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

decreases expression
increases expression

Aspirin results in decreased expression of GFAP mRNA; Aspirin results in decreased expression of GFAP protein
Aspirin results in increased expression of GFAP mRNA

PMID:16516312 PMID:21353610 PMID:22954530

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

GDNF family receptor alpha 3

increases expression

Aspirin results in increased expression of GFRA3 mRNA

NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105

G

gamma-glutamyltransferase 1

decreases activity

Aspirin analog results in decreased activity of GGT1 protein

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

growth hormone inducible transmembrane protein

increases expression

Aspirin results in increased expression of GHITM mRNA

NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879

G

gap junction protein, alpha 1

decreases expression

Aspirin results in decreased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gastrokine 1

affects expression

Aspirin affects the expression of GKN1 mRNA; Aspirin affects the expression of GKN1 protein

NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389

G

G protein subunit beta 2

decreases expression

Aspirin results in decreased expression of GNB2 mRNA

NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019

G

glycoprotein Ib platelet subunit alpha

decreases response to substance
increases response to substance
affects response to substance

GP1BA SNP results in decreased susceptibility to Aspirin
GP1BA polymorphism results in increased susceptibility to Aspirin
GP1BA polymorphism affects the susceptibility to Aspirin

PMID:17245331 PMID:17630485 PMID:19250145

NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774

G

glycoprotein VI

decreases response to substance

GP6 gene polymorphism results in decreased susceptibility to Aspirin

NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326

G

glutamic--pyruvic transaminase

multiple interactions
increases expression

fucoidan inhibits the reaction [Aspirin results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

decreases expression

Aspirin results in decreased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

decreases phosphorylation
increases phosphorylation
decreases activity

Aspirin results in decreased phosphorylation of GSK3B protein
Aspirin results in increased phosphorylation of GSK3B protein
Aspirin results in decreased activity of GSK3B protein

PMID:11593435 PMID:12813129 PMID:19966835

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

affects expression

Aspirin affects the expression of GSN protein

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase alpha 2

affects binding

Aspirin binds to GSTA2 protein

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 1

affects response to substance

GSTM1 mutant form affects the susceptibility to Aspirin

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase omega 1

decreases expression

Aspirin results in decreased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase theta 1

increases expression

Aspirin results in increased expression of GSTT1 protein

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

glutathione S-transferase theta 2

increases expression

Aspirin results in increased expression of GSTT2 protein

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

general transcription factor II I

decreases expression

Aspirin results in decreased expression of GTF2I mRNA

NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243

G

GTP binding protein 2

decreases expression

Aspirin results in decreased expression of GTPBP2 mRNA

NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241

G

guanylate kinase 1

decreases expression

Aspirin results in decreased expression of GUK1 mRNA

NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107

G

granzyme A

decreases expression

Aspirin results in decreased expression of GZMA mRNA

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

H2A.X variant histone

decreases expression

Aspirin results in decreased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

heparin-binding EGF-like growth factor

multiple interactions
increases expression

apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF protein]
Aspirin results in increased expression of HBEGF mRNA; Aspirin results in increased expression of HBEGF protein

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

HCK proto-oncogene, Src family tyrosine kinase

decreases expression

Aspirin results in decreased expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

hematopoietic cell specific Lyn substrate 1

decreases expression

Aspirin results in decreased expression of HCLS1 mRNA

NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014

G

histone deacetylase 1

increases expression

Aspirin results in increased expression of HDAC1 mRNA

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 3

multiple interactions

HDAC3 inhibits the reaction [Aspirin results in increased acetylation of and results in increased activity of NOS3 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]]

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

histone deacetylase 4

increases expression

Aspirin results in increased expression of HDAC4 mRNA

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

heparin binding growth factor

decreases expression

Aspirin results in decreased expression of HDGF mRNA

NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747

G

hepatocyte growth factor

multiple interactions

Aspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]; Aspirin inhibits the reaction [HGF results in increased expression of MMP9]

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

holocarboxylase synthetase

increases expression

Aspirin results in increased expression of HLCS mRNA

NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222

G

high mobility group box 1

multiple interactions

Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

hyaluronan-mediated motility receptor

increases expression

Aspirin results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

increases expression

Aspirin results in increased expression of HMOX1
Aspirin analog results in increased expression of HMOX1 mRNA

PMID:15901601 PMID:19100325

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

decreases expression

Aspirin results in decreased expression of HNF1A mRNA

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

histamine N-methyltransferase

affects response to substance

HNMT gene SNP affects the susceptibility to Aspirin

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

heterogeneous nuclear ribonucleoprotein A1

decreases expression

Aspirin results in decreased expression of HNRNPA1 mRNA

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

heterogeneous nuclear ribonucleoprotein C

decreases expression

Aspirin results in decreased expression of HNRNPC mRNA

NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183

G

heterogeneous nuclear ribonucleoprotein D-like

decreases expression

Aspirin results in decreased expression of HNRNPDL mRNA

NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506

G

heterogeneous nuclear ribonucleoprotein U

increases expression

Aspirin results in increased expression of HNRNPU mRNA

NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588

G

heterogeneous nuclear ribonucleoprotein U-like 1

decreases expression

Aspirin results in decreased expression of HNRNPUL1 mRNA

NCBI chr 1:81,228,404...81,264,121
Ensembl chr 1:81,228,404...81,262,592

G

heat shock transcription factor 1

increases activity

Aspirin results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 1A

increases expression

Aspirin results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

decreases expression

Aspirin results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Aspirin results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

isoleucyl-tRNA synthetase 1

decreases expression

Aspirin results in decreased expression of IARS1 mRNA

NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

Aspirin results in decreased expression of ICAM1 mRNA; Aspirin results in decreased expression of ICAM1 protein
Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]; Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]

PMID:14762100 PMID:16310244 PMID:18059344

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

affects expression

Aspirin affects the expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

indoleamine 2,3-dioxygenase 1

affects response to substance

IDO1 affects the susceptibility to Aspirin

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

IFI30, lysosomal thiol reductase

decreases expression

Aspirin results in decreased expression of IFI30 mRNA

NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175

G

interferon gamma

multiple interactions
increases expression

Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IFNG protein]
Aspirin results in increased expression of IFNG protein
fucoidan promotes the reaction [Aspirin results in increased expression of IFNG protein]
Aspirin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]

PMID:15379866 PMID:19164858 PMID:19788892

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

intraflagellar transport 27

increases expression

Aspirin results in increased expression of IFT27 mRNA

NCBI chr 7:109,738,622...109,754,416
Ensembl chr 7:109,738,622...109,754,416

G

insulin-like growth factor 2

decreases expression

Aspirin results in decreased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor 2 receptor

increases expression

Aspirin results in increased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases activity
decreases phosphorylation
decreases expression

Aspirin results in decreased activity of IKBKB protein
Aspirin results in decreased phosphorylation of IKBKB protein
Aspirin results in decreased expression of IKBKB protein

PMID:16199534 PMID:16310244 PMID:16880202

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

increases response to substance
multiple interactions
increases expression
affects response to substance

IL10 polymorphism results in increased susceptibility to Aspirin
fucoidan promotes the reaction [Aspirin results in increased expression of IL10 protein]
IL10 polymorphism affects the susceptibility to Aspirin

PMID:16030091 PMID:19222424 PMID:19788892

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

multiple interactions

Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

affects response to substance

IL13 polymorphism affects the susceptibility to Aspirin

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17A

affects response to substance

IL17A polymorphism affects the susceptibility to Aspirin

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions
affects response to substance

Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA]
IL18 polymorphism affects the susceptibility to Aspirin

PMID:19164858 PMID:21692767

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions
increases expression

[Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of IL1B mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of IL6 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased phosphorylation of MAPK14 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased phosphorylation of MAPK14 protein]
Aspirin results in increased expression of IL1A mRNA

PMID:14742690 PMID:32816093

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression
affects response to substance

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]; Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Aspirin promotes the reaction [IL1A results in increased expression of IL1B mRNA]; Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]
Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Azoxymethane results in increased expression of IL1B mRNA]; Aspirin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL1B protein]; Aspirin promotes the reaction [Acetic Acid results in increased expression of IL1B protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; lipopolysaccharide, Helicobacter pylori inhibits the reaction [Aspirin results in increased expression of IL1B protein]
Aspirin results in decreased expression of IL1B mRNA
IL1B polymorphism affects the susceptibility to Aspirin
Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA]
Aspirin results in increased expression of IL1B mRNA

PMID:11376495 PMID:11826407 PMID:12126971 PMID:14742690 PMID:14762100 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 2

affects response to substance

IL1R2 affects the susceptibility to Aspirin

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 1 receptor antagonist

multiple interactions

Aspirin inhibits the reaction [Salmonella Vaccines results in increased expression of IL1RN protein]

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

multiple interactions

Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 24

increases expression

Aspirin results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 2 receptor subunit beta

increases expression

Aspirin results in increased expression of IL2RB mRNA

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 2 receptor subunit gamma

decreases expression

Aspirin results in decreased expression of IL2RG mRNA

NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823

G

interleukin 4

multiple interactions
decreases secretion
decreases expression
increases expression

Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Aspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Aspirin inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]; Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism]
Aspirin results in decreased secretion of IL4 protein
Aspirin results in decreased expression of IL4 mRNA
Aspirin results in increased expression of IL4 mRNA

PMID:11238116 PMID:19767084 PMID:20921925

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression
decreases expression

Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Aspirin promotes the reaction [IL1A results in increased expression of IL6 mRNA]; Aspirin results in decreased expression of and results in decreased secretion of IL6 protein; IL6 protein inhibits the reaction [Aspirin results in decreased expression of STAT3 protein modified form]
Aspirin results in increased expression of IL6 protein
Aspirin inhibits the reaction [Oxaliplatin results in increased expression of IL6 mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of IL6 protein]; fucoidan inhibits the reaction [Aspirin results in increased expression of IL6 protein]
Aspirin inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA]; Aspirin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Aspirin results in decreased expression of IL6 protein
Aspirin results in decreased expression of IL6 mRNA

PMID:14742690 PMID:15379866 PMID:16413386 PMID:19595669 PMID:19788892 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

decreases expression

Aspirin results in decreased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

interleukin 7 receptor

increases expression

Aspirin results in increased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

integrin-linked kinase

decreases activity
decreases expression

Aspirin results in decreased activity of ILK protein
Aspirin results in decreased expression of ILK mRNA

PMID:11593435 PMID:15928584

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

insulin induced gene 1

increases expression

Aspirin results in increased expression of INSIG1 mRNA

PMID:12800193 PMID:15928584

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

IQ motif containing GTPase activating protein 2

increases expression

Aspirin results in increased expression of IQGAP2 mRNA

NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279

G

interferon regulatory factor 1

increases expression

Aspirin results in increased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

interferon regulatory factor 9

decreases expression

Aspirin results in decreased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

G

insulin receptor substrate 1

affects response to substance

IRS1 polymorphism affects the susceptibility to Aspirin

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

integrin subunit alpha 2

decreases response to substance
multiple interactions

ITGA2 polymorphism results in decreased susceptibility to Aspirin
ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel]

PMID:15205592 PMID:16214444 PMID:18231737

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 2b

decreases expression
multiple interactions

Aspirin results in decreased expression of ITGA2B protein
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]

PMID:15140583 PMID:15381054 PMID:18413191

NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168

G

integrin subunit alpha 5

decreases expression

Aspirin results in decreased expression of ITGA5 mRNA

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit beta 2

multiple interactions

Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

multiple interactions
increases expression
decreases response to substance
affects response to substance

Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]; ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein]
Aspirin results in increased expression of ITGB3 mRNA; Aspirin results in increased expression of ITGB3 protein
ITGB3 gene polymorphism results in decreased susceptibility to Aspirin; ITGB3 polymorphism results in decreased susceptibility to Aspirin; ITGB3 results in decreased susceptibility to Aspirin
ITGB3 gene polymorphism affects the susceptibility to Aspirin

PMID:13678940 PMID:15381054 PMID:15840736 PMID:16153930 PMID:16675000 More...

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

integrin subunit beta 4

decreases expression

Aspirin results in decreased expression of ITGB4 mRNA

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Aspirin inhibits the reaction [Glucose results in increased expression of JUN protein]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter]
Aspirin results in increased expression of JUN mRNA

PMID:14976132 PMID:16600694 PMID:16893520 PMID:20457246

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Aspirin results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

Aspirin results in decreased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lysine acetyltransferase 7

decreases expression

Aspirin results in decreased expression of KAT7 mRNA

NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567

G

potassium calcium-activated channel subfamily M regulatory beta subunit 4

decreases expression

Aspirin results in decreased expression of KCNMB4 mRNA

NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278

G

potassium channel tetramerization domain containing 13

increases expression

Aspirin results in increased expression of KCTD13 mRNA

NCBI chr 1:181,534,534...181,552,843
Ensembl chr 1:181,534,515...181,552,881

G

lysine demethylase 5B

decreases expression

Aspirin results in decreased expression of KDM5B mRNA

NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872

G

kinesin family member 20B

decreases expression

Aspirin results in decreased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 21A

increases expression

Aspirin results in increased expression of KIF21A mRNA

NCBI chr 7:122,062,523...122,179,051
Ensembl chr 7:122,062,537...122,178,999

G

kinesin family member 3a

increases expression
affects response to substance

Aspirin results in increased expression of KIF3A mRNA
KIF3A polymorphism affects the susceptibility to Aspirin

NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191

G

killer cell lectin like receptor B1A

increases expression

Aspirin results in increased expression of KLRB1 mRNA

NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675

G

kininogen 1

decreases activity

Aspirin results in decreased activity of KNG1

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

karyopherin subunit alpha 3

increases expression

Aspirin results in increased expression of KPNA3 mRNA

NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419

G

LCK proto-oncogene, Src family tyrosine kinase

decreases expression

Aspirin results in decreased expression of LCK mRNA

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

lipocalin 2

multiple interactions

Aspirin inhibits the reaction [Azoxymethane results in decreased expression of LCN2 mRNA]

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lactase

multiple interactions
increases activity
decreases activity

[Aspirin results in decreased activity of LCT protein] which results in decreased transport of Glucose
Aspirin results in increased activity of LCT; Aspirin results in increased activity of LCT protein

PMID:16382204 PMID:16855794 PMID:17147060 PMID:18604318

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

low density lipoprotein receptor

multiple interactions

Aspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid]
Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; Aspirin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Aspirin promotes the reaction [Cholesterol, LDL binds to LDLR protein]

PMID:10395027 PMID:20530721

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin

multiple interactions

[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

LIF, interleukin 6 family cytokine

increases expression

Aspirin results in increased expression of LIF mRNA; Aspirin results in increased expression of LIF protein

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lamin A/C

multiple interactions

Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of LMNA protein]

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

LIM domain 7

increases expression

Aspirin results in increased expression of LMO7 mRNA

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

lymphotoxin alpha

affects response to substance

LTA gene SNP affects the susceptibility to Aspirin

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

leukotriene C4 synthase

affects response to substance

LTC4S affects the susceptibility to Aspirin; LTC4S gene SNP affects the susceptibility to Aspirin; LTC4S polymorphism affects the susceptibility to Aspirin

PMID:15100686 PMID:16433794 PMID:19767084 PMID:19862937 PMID:20485159

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

lymphocyte antigen 9

increases expression

Aspirin results in increased expression of LY9 mRNA

NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823

G

LYN proto-oncogene, Src family tyrosine kinase

increases expression

Aspirin results in increased expression of LYN mRNA

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

MAP-kinase activating death domain

decreases expression

Aspirin results in decreased expression of MADD mRNA

NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701

G

mitogen activated protein kinase kinase 1

increases expression

Aspirin results in increased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

decreases expression

Aspirin results in decreased expression of MAP2K2 mRNA

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase kinase 5

decreases expression

Aspirin results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

Aspirin results in decreased expression of MAP4K4 mRNA

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen activated protein kinase 1

multiple interactions
increases activity
decreases expression

Aspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Aspirin results in increased activity of MAPK1 protein
Aspirin results in decreased expression of MAPK1 protein modified form

PMID:10993886 PMID:11981761 PMID:15447849 PMID:20116423 PMID:21617849 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 12

decreases expression

Aspirin results in decreased expression of MAPK12 mRNA

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen activated protein kinase 14

multiple interactions
increases phosphorylation

Aspirin promotes the reaction [IL1A results in increased phosphorylation of MAPK14 protein]; IL1A promotes the reaction [Aspirin results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases expression
increases activity

Aspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Aspirin results in decreased expression of MAPK3 protein modified form
Aspirin results in increased activity of MAPK3 protein

PMID:10993886 PMID:11981761 PMID:15447849 PMID:20116423 PMID:21617849 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MAPK activated protein kinase 3

decreases expression

Aspirin results in decreased expression of MAPKAPK3 mRNA

NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568

G

melanoma cell adhesion molecule

increases expression

Aspirin results in increased expression of MCAM mRNA

NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

Aspirin results in decreased expression of MCL1 protein
Aspirin results in increased degradation of and results in decreased expression of MCL1 protein

PMID:19936928 PMID:20116423

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance complex component 5

decreases expression

Aspirin results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

decreases expression

Aspirin results in decreased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

MDM2 proto-oncogene

decreases expression

Aspirin results in decreased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mediator complex subunit 4

increases expression

Aspirin results in increased expression of MED4 mRNA

NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression
increases expression
multiple interactions

Aspirin results in decreased expression of CMET protein
Aspirin results in increased expression of MET mRNA
CTNNB1 affects the reaction [Aspirin results in decreased expression of CMET protein]

PMID:16878161 PMID:32816093

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microRNA 1306

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of MIR1306 mRNA]

NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719

G

microRNA 26b

multiple interactions

Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of MIR26B mRNA]

NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680

G

marker of proliferation Ki-67

multiple interactions

Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

myeloid leukemia factor 2

decreases expression

Aspirin results in decreased expression of MLF2 mRNA

NCBI chr 4:157,739,651...157,744,325
Ensembl chr 4:157,728,756...157,744,317

G

matrix metallopeptidase 13

increases expression
multiple interactions

Aspirin results in increased expression of MMP13 mRNA
[Aspirin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein

PMID:12800193 PMID:21360558

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

decreases expression
multiple interactions
decreases secretion

Aspirin results in decreased expression of MMP2
[Aspirin co-treated with Carbon Tetrachloride] results in increased expression of MMP2 protein
Aspirin results in decreased secretion of MMP2 protein
Aspirin results in decreased expression of MMP2 mRNA

PMID:18971601 PMID:19462226 PMID:21360558

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 7

decreases expression
multiple interactions

Aspirin results in decreased expression of MMP7 mRNA
Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]

PMID:12800193 PMID:20043115

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

multiple interactions
decreases secretion
decreases expression
decreases activity

Aspirin inhibits the reaction [HGF results in increased expression of MMP9]
Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Aspirin results in decreased secretion of MMP9 protein
Aspirin results in decreased expression of MMP9 mRNA
Aspirin results in decreased expression of MMP9; Aspirin results in decreased expression of MMP9 mRNA
Aspirin results in decreased activity of MMP9 protein

PMID:11981761 PMID:15928584 PMID:18971601 PMID:19462226 PMID:19880272 More...

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MOB kinase activator 2

increases expression

Aspirin results in increased expression of MOB2 mRNA

NCBI chr 1:197,092,991...197,149,978
Ensembl chr 1:197,092,994...197,149,933

G

myeloperoxidase

multiple interactions
increases expression

Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein]

PMID:21893697 PMID:22039321 PMID:30885738

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

myelin protein zero-like 1

increases expression

Aspirin results in increased expression of MPZL1 mRNA

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

G

mitochondrial ribosomal protein L46

increases expression

Aspirin results in increased expression of MRPL46 mRNA

NCBI chr 1:132,698,872...132,707,639
Ensembl chr 1:132,698,601...132,707,628

G

membrane spanning 4-domains A2

affects response to substance

MS4A2 polymorphism affects the susceptibility to Aspirin; MS4A2 SNP affects the susceptibility to Aspirin

PMID:16839402 PMID:18379861 PMID:18534082

NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310

G

mitochondrially encoded cytochrome c oxidase I

increases expression

Aspirin results in increased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

increases expression
multiple interactions

Aspirin results in increased expression of ND1 mRNA
Aspirin inhibits the reaction [Cisplatin results in decreased expression of ND1 mRNA]

PMID:8554334 PMID:37179038

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3

multiple interactions

Aspirin inhibits the reaction [Cisplatin results in decreased expression of ND3 mRNA]

NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798

G

metallothionein 1

increases expression
multiple interactions

Aspirin results in increased expression of MT1A mRNA
Aspirin inhibits the reaction [Copper results in increased activity of MT1 promoter]

PMID:12800193 PMID:14576086

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metastasis associated 1

increases expression

Aspirin results in increased expression of MTA1 mRNA

NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641

G

mechanistic target of rapamycin kinase

multiple interactions

Aspirin results in decreased phosphorylation of and results in increased expression of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

microsomal triglyceride transfer protein

decreases expression

Aspirin results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

MX dynamin like GTPase 1

decreases expression

Aspirin results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression
multiple interactions

Aspirin results in decreased expression of MYC mRNA
Aspirin results in decreased expression of MYC mRNA; Aspirin results in decreased expression of MYC protein
Aspirin results in increased expression of MYC mRNA
CTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein]

PMID:11906190 PMID:12800193 PMID:16878161 PMID:20457246 PMID:21721879

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

decreases expression

Aspirin results in decreased expression of NAA15 mRNA

NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

increases expression

Aspirin results in increased expression of NAA38 mRNA

NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494

G

N-acetyltransferase 1

decreases activity

Aspirin results in decreased activity of NAT1 protein

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

affects response to substance

NAT2 polymorphism affects the susceptibility to Aspirin

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

neutrophil cytosolic factor 1

multiple interactions
decreases expression

Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Aspirin results in decreased expression of NCF1 mRNA

PMID:21353610 PMID:22306536

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

N-deacetylase and N-sulfotransferase 2

increases expression

Aspirin results in increased expression of NDST2 mRNA

NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801

G

NADH:ubiquinone oxidoreductase subunit S4

multiple interactions

Aspirin inhibits the reaction [Cisplatin results in decreased expression of NDUFS4 mRNA]

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression
decreases localization
increases activity

Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Aspirin promotes the reaction [NFKB1 protein binds to SAT1 promoter]
Aspirin results in decreased expression of NFKB1 mRNA
Aspirin results in decreased localization of NFKB1 protein
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
Aspirin results in increased activity of NFKB1 protein

PMID:9281604 PMID:11826407 PMID:14976132 PMID:15489888 PMID:16262603 More...

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
decreases expression
decreases degradation
increases expression
increases degradation

Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIA protein]; Aspirin results in decreased phosphorylation of and results in increased expression of NFKBIA protein
Aspirin results in decreased expression of NFKBIA mRNA
Aspirin results in decreased degradation of NFKBIA protein
Aspirin results in increased expression of NFKBIA protein
Aspirin results in increased degradation of NFKBIA protein

PMID:14753751 PMID:15036249 PMID:15188000 PMID:15489888 PMID:15770215 More...

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein]

PMID:14753751 PMID:15036249

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

NFKB inhibitor zeta

increases expression

Aspirin results in increased expression of NFKBIZ mRNA

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

nerve growth factor receptor

increases expression

Aspirin analog results in increased expression of NGFR protein

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

ninjurin 1

decreases expression

Aspirin results in decreased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

natural killer cell granule protein 7

decreases expression

Aspirin results in decreased expression of NKG7 mRNA

NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983

G

NK2 homeobox 1

affects expression

Aspirin affects the expression of NKX2-1 mRNA

NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791

G

NLR family, pyrin domain containing 3

affects response to substance

NLRP3 SNP affects the susceptibility to Aspirin

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NME/NM23 nucleoside diphosphate kinase 6

increases expression

Aspirin results in increased expression of NME6 mRNA

NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301

G

nucleolar and coiled-body phosphoprotein 1

decreases expression

Aspirin results in decreased expression of NOLC1 mRNA

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

G

nitric oxide synthase 2

multiple interactions
decreases expression
increases expression

Ascorbic Acid inhibits the reaction [Aspirin results in increased expression of NOS2 protein]
[Aspirin results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide
Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]

PMID:10860828 PMID:16310244 PMID:17218764 PMID:21893697

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

Aspirin inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; Aspirin inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; Aspirin inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]; Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]; Aspirin results in increased acetylation of and results in increased activity of NOS3 protein; HDAC3 inhibits the reaction [Aspirin results in increased acetylation of and results in increased activity of NOS3 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]]

PMID:19520256 PMID:20705923

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

aminopeptidase puromycin sensitive

decreases expression

Aspirin results in decreased expression of NPEPPS mRNA

NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967

G

natriuretic peptide B

affects expression
multiple interactions
increases expression

Aspirin affects the expression of NPPB mRNA
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
Aspirin results in increased expression of NPPB mRNA

PMID:12800193 PMID:21378469

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

natriuretic peptide receptor 1

decreases expression

Aspirin results in decreased expression of NPR1 mRNA

NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [Aspirin analog results in increased activity of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 4, group A, member 3

increases expression

Aspirin results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

neuronal cell adhesion molecule

decreases expression

Aspirin results in decreased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

nuclear respiratory factor 1

multiple interactions

Aspirin inhibits the reaction [Cisplatin results in decreased expression of NRF1 protein]

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

NUBP iron-sulfur cluster assembly factor 2

decreases expression

Aspirin results in decreased expression of NUBP2 mRNA

PMID:15456535 PMID:15928584

NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969

G

2'-5' oligoadenylate synthetase 1A

increases expression

Aspirin results in increased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

ornithine decarboxylase 1

increases expression
increases response to substance

Aspirin results in increased expression of ODC1 mRNA
ODC1 polymorphism results in increased susceptibility to Aspirin

PMID:14976132 PMID:18413818

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

origin recognition complex, subunit 4

increases expression

Aspirin results in increased expression of ORC4 mRNA

NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824

G

oncostatin M

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of OSM protein]

NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313

G

odd-skipped related transcription factor 1

increases expression

Aspirin results in increased expression of OSR1 mRNA

NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817

G

ornithine transcarbamylase

decreases expression

Aspirin results in decreased expression of OTC protein

NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918

G

purinergic receptor P2Y1

decreases response to substance
affects response to substance

P2RY1 polymorphism results in decreased susceptibility to Aspirin; P2RY1 SNP results in decreased susceptibility to Aspirin
P2RY1 affects the susceptibility to Aspirin

PMID:15757620 PMID:17559347 PMID:21429568

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

G

purinergic receptor P2Y12

affects response to substance

P2RY12 affects the susceptibility to Aspirin

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

increases expression

Aspirin results in increased expression of PAG1 mRNA

NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein]; Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Aspirin promotes the reaction [troglitazone results in increased cleavage of PARP1 protein]; Aspirin results in increased cleavage of and results in increased activity of PARP1 protein; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; troglitazone promotes the reaction [Aspirin results in increased cleavage of PARP1 protein]

PMID:9694730 PMID:11228543 PMID:11532860 PMID:15481331 PMID:16199534 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly(rC) binding protein 1

decreases expression

Aspirin results in decreased expression of PCBP1 mRNA

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

protocadherin 17

increases expression

Aspirin results in increased expression of PCDH17 mRNA

NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999

G

proliferating cell nuclear antigen

increases expression

Aspirin results in increased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

PEST proteolytic signal containing nuclear protein

increases expression

Aspirin results in increased expression of PCNP mRNA

NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348

G

proprotein convertase subtilisin/kexin type 1

decreases expression

Aspirin results in decreased expression of PCSK1 mRNA

NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434

G

proprotein convertase subtilisin/kexin type 7

decreases expression

Aspirin results in decreased expression of PCSK7 mRNA

NCBI chr 8:46,202,079...46,224,699
Ensembl chr 8:46,202,131...46,224,705

G

programmed cell death 10

increases expression

Aspirin results in increased expression of PDCD10 mRNA

NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018

G

platelet derived growth factor subunit B

multiple interactions

Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

PDZ and LIM domain 7

decreases expression

Aspirin results in decreased expression of PDLIM7 mRNA

NCBI chr17:9,124,565...9,139,814
Ensembl chr17:9,124,649...9,139,811

G

platelet and endothelial cell adhesion molecule 1

decreases expression

Aspirin results in decreased expression of PECAM1 mRNA; Aspirin results in decreased expression of PECAM1 protein

PMID:15381054 PMID:15456535

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

penta-EF hand domain containing 1

decreases expression

Aspirin results in decreased expression of PEF1 mRNA

NCBI chr 5:142,451,791...142,475,061
Ensembl chr 5:142,451,778...142,475,067

G

peptidase D

increases activity

Aspirin results in increased activity of PEPD protein

NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231

G

platelet factor 4

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PF4 protein]

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

decreases expression

Aspirin results in decreased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

profilin 1

decreases expression

Aspirin results in decreased expression of PFN1 mRNA

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

prohibitin 1

decreases expression

Aspirin results in decreased expression of PHB1 mRNA

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

prohibitin 2

decreases expression

Aspirin results in decreased expression of PHB2 mRNA

NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272

G

phosphatidylinositol 4-kinase beta

decreases expression

Aspirin results in decreased expression of PI4KB mRNA

NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488

G

phosphatidylinositol binding clathrin assembly protein

decreases expression

Aspirin results in decreased expression of PICALM mRNA

NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

decreases expression

Aspirin results in decreased expression of PIK3C2A mRNA

NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

Aspirin results in decreased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

paired immunoglobin like type 2 receptor beta 2 like 8

increases expression

Aspirin results in increased expression of ZNF37A mRNA

NCBI chr12:17,744,315...17,756,074
Ensembl chr12:17,752,830...17,755,922

G

paired-like homeodomain 1

increases expression

Aspirin results in increased expression of PITX1 mRNA

NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291

G

phospholipase A2 group 4A

decreases expression

Aspirin results in decreased expression of PLA2G4A mRNA

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

phospholipase A2 group VI

increases expression

Aspirin results in increased expression of PLA2G6 mRNA

NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114

G

plasminogen activator, urokinase receptor

multiple interactions
affects expression
increases expression

Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter]; Aspirin promotes the reaction [H4C16 protein modified form binds to PLAUR promoter]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter]
Aspirin affects the expression of PLAUR mRNA
Aspirin results in increased expression of PLAUR mRNA; Aspirin results in increased expression of PLAUR protein

PMID:12800193 PMID:16893520

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase C, delta 4

increases expression

Aspirin results in increased expression of PLCD4 mRNA

NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453

G

perilipin 2

increases expression

Aspirin results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression
increases response to substance

Aspirin results in increased expression of PMAIP1 mRNA; Aspirin results in increased expression of PMAIP1 protein
PMAIP1 results in increased susceptibility to Aspirin

PMID:15928584 PMID:19936928

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

RNA polymerase II subunit A

increases expression

Aspirin results in increased expression of POLR2A mRNA

NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455

G

paraoxonase 1

increases expression
increases activity
multiple interactions

Aspirin results in increased expression of PON1 mRNA
Aspirin results in increased activity of PON1 mRNA; Aspirin results in increased activity of PON1 protein
AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA]

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

cytochrome p450 oxidoreductase

decreases expression

Aspirin results in decreased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxisome proliferator activated receptor alpha

affects activity
multiple interactions
increases expression
decreases expression
decreases activity

Aspirin affects the activity of PPARA protein
PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]]
Aspirin results in increased expression of PPARA mRNA
Aspirin results in increased expression of PPARA; Aspirin results in increased expression of PPARA mRNA; Aspirin results in increased expression of PPARA protein
Aspirin results in decreased expression of PPARA protein
Aspirin results in decreased activity of PPARA protein

PMID:15646027 PMID:16816107 PMID:18971601 PMID:19462226 PMID:19880272 More...

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

decreases activity
increases expression
decreases expression

Aspirin results in decreased activity of PPARD protein
Aspirin results in increased expression of PPARD mRNA
Aspirin results in decreased expression of PPARD protein

PMID:12800193 PMID:15646027 PMID:18678619

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

decreases activity
decreases expression
increases expression
multiple interactions

Aspirin results in decreased activity of PPARG protein
Aspirin results in decreased expression of PPARG mRNA
Aspirin results in increased expression of PPARG mRNA
Aspirin results in increased expression of PPARG; Aspirin results in increased expression of PPARG mRNA; Aspirin results in increased expression of PPARG protein
Aspirin inhibits the reaction [Niacin results in increased activity of PPARG protein]

PMID:15646027 PMID:16386710 PMID:18222077 PMID:18971601 PMID:19462226 More...

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

Aspirin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

pro-platelet basic protein

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PPBP protein]

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

G

peptidylprolyl isomerase B

decreases expression

Aspirin results in decreased expression of PPIB mRNA

NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428

G

peptidylprolyl isomerase G

increases expression

Aspirin results in increased expression of PPIG mRNA

NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926

G

protein phosphatase 1, regulatory subunit 12A

decreases expression

Aspirin results in decreased expression of PPP1R12A mRNA

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Aspirin results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

decreases expression

Aspirin results in decreased expression of PPP1R2 mRNA

NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463

G

protein phosphatase 4, catalytic subunit

decreases expression

Aspirin results in decreased expression of PPP4C mRNA

NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659

G

prolyl endopeptidase

decreases expression

Aspirin results in decreased expression of PREP mRNA

NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466

G

protein kinase AMP-activated catalytic subunit alpha 1

increases expression
multiple interactions

Aspirin results in increased expression of PRKAA1 protein modified form
Aspirin inhibits the reaction [Cisplatin results in decreased expression of PRKAA1 protein]
CES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form]

PMID:25743752 PMID:37179038

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, beta

multiple interactions
affects expression

Aspirin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]
Aspirin affects the expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

increases cleavage

Aspirin results in increased cleavage of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, epsilon

multiple interactions

Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PRKCE protein]

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

prion protein

increases expression

Aspirin results in increased expression of PRNP mRNA

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

phosphoserine aminotransferase 1

decreases expression

Aspirin results in decreased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

pleckstrin and Sec7 domain containing

increases expression

Aspirin results in increased expression of PSD mRNA

NCBI chr 1:245,173,279...245,188,681
Ensembl chr 1:245,173,279...245,189,356

G

proteasome 26S subunit, ATPase 6

decreases expression

Aspirin results in decreased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

proteasome 26S subunit, non-ATPase 12

increases expression

Aspirin results in increased expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

prostaglandin D2 receptor 2

affects response to substance

PTGDR2 gene SNP affects the susceptibility to Aspirin

NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213

G

prostaglandin E receptor 2

affects response to substance

PTGER2 SNP affects the susceptibility to Aspirin

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin E receptor 3

affects response to substance

PTGER3 polymorphism affects the susceptibility to Aspirin

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

G

prostaglandin E synthase

decreases expression

Aspirin results in decreased expression of PTGES mRNA; Aspirin results in decreased expression of PTGES protein

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin I2 receptor

affects response to substance

PTGIR gene SNP affects the susceptibility to Aspirin

NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979

G

prostaglandin-endoperoxide synthase 1

multiple interactions
affects expression
affects response to substance
decreases activity
decreases expression
decreases response to substance
increases acetylation

[Aspirin results in increased acetylation of PTGS1 protein] which results in decreased chemical synthesis of Thromboxane A2; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; Aspirin inhibits the reaction [PTGS1 protein results in increased susceptibility to Methamphetamine]; PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]]
Aspirin affects the expression of PTGS1 protein
PTGS1 polymorphism affects the susceptibility to Aspirin
Aspirin analog results in decreased activity of PTGS1 protein; Aspirin results in decreased activity of PTGS1 protein
Aspirin results in decreased expression of PTGS1 mRNA
Aspirin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]; PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin]
PTGS1 gene polymorphism results in decreased susceptibility to Aspirin; PTGS1 gene SNP results in decreased susceptibility to Aspirin

PMID:12242329 PMID:15236176 PMID:15843042 PMID:16141368 PMID:16150050 More...

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases activity
increases expression
decreases expression
affects response to substance
decreases degradation

Ascorbic Acid inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [PTGS2 protein results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Aspirin results in decreased degradation of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]
Aspirin results in decreased activity of PTGS2 protein; Aspirin results in decreased activity of PTGS2 protein mutant form
Aspirin results in increased expression of PTGS2; Aspirin results in increased expression of PTGS2 mRNA; Aspirin results in increased expression of PTGS2 protein
Aspirin results in decreased expression of PTGS2 protein
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
[[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
PTGS2 gene SNP affects the susceptibility to Aspirin; PTGS2 SNP affects the susceptibility to Aspirin
Aspirin results in decreased expression of PTGS2 mRNA; Aspirin results in decreased expression of PTGS2 protein

PMID:9726391 PMID:10706128 PMID:12231391 PMID:12781040 PMID:14742690 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase 4A1

increases expression

Aspirin results in increased expression of PTP4A1 mRNA

NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964

G

protein tyrosine phosphatase, receptor type, C-associated protein

decreases expression

Aspirin results in decreased expression of PTPRCAP mRNA

NCBI chr 1:201,449,133...201,451,293
Ensembl chr 1:201,449,113...201,451,288

G

pumilio RNA-binding family member 2

increases expression

Aspirin results in increased expression of PUM2 mRNA

NCBI chr 6:31,462,879...31,542,976
Ensembl chr 6:31,462,872...31,542,976

G

purine rich element binding protein A

increases expression

Aspirin results in increased expression of PURA mRNA

NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513

G

pseudouridine synthase 1

increases expression

Aspirin results in increased expression of PUS1 mRNA

NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196

G

paxillin

decreases expression

Aspirin results in decreased expression of PXN mRNA

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

glycogen phosphorylase L

affects binding

Aspirin binds to PYGL protein

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

RAB2A, member RAS oncogene family

increases expression

Aspirin results in increased expression of RAB2A mRNA

NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899

G

Rab geranylgeranyltransferase subunit alpha

increases expression

Aspirin results in increased expression of RABGGTA mRNA

NCBI chr15:29,206,328...29,213,398
Ensembl chr15:29,206,157...29,213,348

G

Rac family small GTPase 1

increases expression

Aspirin results in increased expression of RAC1 mRNA; Aspirin results in increased expression of RAC1 protein

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

Aspirin results in decreased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS like proto-oncogene B

decreases expression

Aspirin results in decreased expression of RALB mRNA

NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202

G

RB transcriptional corepressor 1

multiple interactions
increases expression
decreases expression

Aspirin inhibits the reaction [troglitazone results in decreased expression of RB1 protein modified form]; Aspirin promotes the reaction [troglitazone results in increased expression of RB1 protein]; troglitazone inhibits the reaction [Aspirin results in decreased expression of RB1 protein modified form]; troglitazone promotes the reaction [Aspirin results in increased expression of RB1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

receptor accessory protein 6

increases expression

Aspirin results in increased expression of REEP6 mRNA

NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597

G

regenerating family member 1 alpha

decreases response to substance
increases expression

REG1A results in decreased susceptibility to Aspirin
Aspirin results in increased expression of REG1A mRNA; Aspirin results in increased expression of REG1A protein

NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases localization
increases localization

Aspirin inhibits the reaction [Glucose results in increased expression of RELA protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Aspirin results in decreased localization of and results in decreased activity of RELA protein
Aspirin results in decreased localization of RELA protein
[telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of RELA protein]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] affects the localization of and results in increased phosphorylation of RELA protein]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
Aspirin results in increased localization of RELA protein

PMID:9281604 PMID:10328874 PMID:11826407 PMID:15188000 PMID:15489888 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

decreases activity

Aspirin results in decreased activity of REN protein

PMID:7994448 PMID:19805643

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

regulator of G-protein signaling 7 binding protein

affects response to substance

RGS7BP polymorphism affects the susceptibility to Aspirin

NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505

G

ras homolog family member G

decreases expression

Aspirin results in decreased expression of RHOG mRNA

NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257

G

ribonuclease A family member 1, pancreatic

increases expression

Aspirin results in increased expression of RNASE1 mRNA

NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624

G

ribonuclease A family member 6

increases expression

Aspirin results in increased expression of RNASE6 mRNA

NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328

G

Rho family GTPase 2

increases expression

Aspirin results in increased expression of RND2 mRNA

NCBI chr10:86,399,151...86,402,750
Ensembl chr10:86,399,148...86,402,742

G

ring finger protein 26

increases expression

Aspirin results in increased expression of RNF26 mRNA

NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331

G

ribosomal protein L34

increases expression

Aspirin results in increased expression of RPL34 mRNA

NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111

G

ribophorin I

decreases expression

Aspirin results in decreased expression of RPN1 mRNA

NCBI chr 4:120,543,667...120,565,069
Ensembl chr 4:120,543,667...120,565,069

G

ribosomal protein S16

increases expression

Aspirin results in increased expression of RPS16 mRNA

NCBI chr 1:83,643,066...83,646,056
Ensembl chr 1:83,643,130...83,646,206

G

ribosomal protein S19

increases expression

Aspirin results in increased expression of RPS19 mRNA

NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508

G

ribosomal protein S27a

increases expression

Aspirin results in increased expression of RPS27A mRNA

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S6

decreases phosphorylation

Aspirin results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

multiple interactions

Aspirin results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RT1 class II, locus Db1

affects response to substance

HLA-DRB1 gene SNP affects the susceptibility to Aspirin

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class Ib, locus M3, gene 1

decreases expression

Aspirin results in decreased expression of HLA-G mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

S100 calcium binding protein A11

decreases expression

Aspirin results in decreased expression of S100A11 mRNA

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium-binding protein A4

increases expression
decreases expression

Aspirin results in increased expression of S100A4 mRNA
Aspirin results in decreased expression of S100A4 mRNA

PMID:14976132 PMID:20457246

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

spermidine/spermine N1-acetyl transferase 1

multiple interactions
increases expression

Aspirin promotes the reaction [NFKB1 protein binds to SAT1 promoter]; Aspirin results in increased expression of and results in increased activity of SAT1 protein
Aspirin results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

suprabasin

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SBSN protein]

NCBI chr 1:85,978,970...86,006,034
Ensembl chr 1:86,001,567...86,006,034

G

scavenger receptor class B, member 1

affects expression
increases expression
decreases expression
multiple interactions

Aspirin affects the expression of SCARB1 mRNA
Aspirin results in increased expression of SCARB1 mRNA; Aspirin results in increased expression of SCARB1 protein
Aspirin affects the expression of SCARB1 protein
Aspirin results in decreased expression of SCARB1 mRNA
[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein; Aspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]; Aspirin results in decreased expression of and results in decreased activity of SCARB1 protein; Aspirin results in increased expression of and results in increased activity of SCARB1 protein

PMID:15037193 PMID:16816107 PMID:20137092

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

sec1 family domain containing 2

increases expression

Aspirin results in increased expression of SCFD2 mRNA

NCBI chr14:33,683,348...34,008,232
Ensembl chr14:33,683,273...34,008,213

G

sodium voltage-gated channel beta subunit 1

increases expression

Aspirin results in increased expression of SCN1B mRNA

NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739

G

syndecan 4

decreases expression

Aspirin results in decreased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

serine dehydratase

increases expression

Aspirin results in increased expression of SDS mRNA

NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203

G

SEC13 homolog, nuclear pore and COPII coat complex component

decreases expression

Aspirin results in decreased expression of SEC13 mRNA

NCBI chr 4:146,877,739...146,891,130
Ensembl chr 4:146,875,524...146,891,173

G

selenoprotein M

increases expression

Aspirin results in increased expression of SELENOM mRNA

NCBI chr14:78,395,826...78,398,429
Ensembl chr14:78,395,826...78,398,429

G

selectin L

decreases expression

Aspirin results in decreased expression of SELL protein

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

selectin P

decreases expression
multiple interactions
increases expression

Aspirin results in decreased expression of SELP protein
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]
Aspirin results in increased expression of SELP protein

PMID:15140583 PMID:15381054 PMID:16756193 PMID:17543677 PMID:18413191

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serpin family A member 1

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SERPINA1 protein]

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family A member 3N

decreases expression
increases expression

Aspirin results in decreased expression of SERPINA3 mRNA
Aspirin results in increased expression of SERPINA3 mRNA

PMID:11906190 PMID:15456535

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 1A

decreases expression

Aspirin results in decreased expression of SERPINB1 mRNA

NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102

G

serpin family B member 2

decreases expression

Aspirin results in decreased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family B member 5

increases expression

Aspirin results in increased expression of SERPINB5 protein

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

splicing factor proline and glutamine rich

decreases expression

Aspirin results in decreased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

surfactant protein D

increases expression

Aspirin results in increased expression of SFTPD mRNA

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

sucrase-isomaltase

increases activity
decreases activity

Aspirin results in increased activity of SI protein
Aspirin results in decreased activity of SI protein

PMID:9399670 PMID:18604318

NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260

G

siah E3 ubiquitin protein ligase 2

decreases expression

Aspirin results in decreased expression of SIAH2 mRNA

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950

G

sirtuin 1

multiple interactions

Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; Aspirin inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein]; Aspirin inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 16 member 1

multiple interactions
decreases expression

Aspirin affects the reaction [SLC16A1 protein results in increased uptake of Butyrates]
Aspirin results in decreased expression of SLC16A1 mRNA

PMID:11906190 PMID:19023563

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 22 member 2

affects response to substance

SLC22A2 polymorphism affects the susceptibility to Aspirin

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22, member 25

decreases activity

Aspirin results in decreased activity of SLC22A9 protein

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 22 member 6

decreases activity

Aspirin results in decreased activity of SLC22A6 protein

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 7

decreases activity

Aspirin results in decreased activity of SLC22A7 protein

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

increases expression

Aspirin results in increased expression of SLC22A8 mRNA

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 25 member 5

increases expression

Aspirin results in increased expression of SLC25A5 mRNA

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 6 member 12

affects response to substance

SLC6A12 polymorphism affects the susceptibility to Aspirin

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 7 member 11

increases expression

Aspirin results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

decreases expression
increases expression

Aspirin results in decreased expression of SLPI mRNA
Aspirin results in increased expression of SLPI mRNA

PMID:15928584 PMID:32816093

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

small ArfGAP2

affects response to substance

SMAP2 protein affects the susceptibility to Aspirin

NCBI chr 5:134,530,542...134,576,938
Ensembl chr 5:134,530,543...134,576,938

G

structural maintenance of chromosomes 4

decreases expression

Aspirin results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

SMAD specific E3 ubiquitin protein ligase 2

increases expression

Aspirin results in increased expression of SMURF2 mRNA

NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488

G

synuclein alpha

decreases expression

Aspirin results in decreased expression of SNCA mRNA

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

suppressor of cytokine signaling 2

increases expression
multiple interactions

Aspirin results in increased expression of SOCS2 mRNA
butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [Aspirin results in increased expression of SOCS2 mRNA]; SOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

superoxide dismutase 1

multiple interactions

Aspirin inhibits the reaction [Cisplatin results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression
multiple interactions
increases expression

Aspirin results in decreased expression of SOD2 mRNA
rebamipide promotes the reaction [Aspirin results in increased expression of SOD2 protein]

PMID:21353610 PMID:22653900

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sperm associated antigen 6

increases expression

Aspirin results in increased expression of SPAG6 mRNA

NCBI chr17:81,352,372...81,401,504
Ensembl chr17:81,349,084...81,401,501

G

secreted protein acidic and cysteine rich

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SPARC protein]

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

secreted phosphoprotein 1

affects expression

Aspirin affects the expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

spectrin, alpha, non-erythrocytic 1

decreases expression

Aspirin results in decreased expression of SPTAN1 mRNA

PMID:15456535 PMID:15928584

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

sushi-repeat-containing protein, X-linked

decreases expression

Aspirin results in decreased expression of SRPX mRNA

NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882

G

signal sequence receptor subunit 3

increases expression

Aspirin results in increased expression of SSR3 mRNA

NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132

G

Stam binding protein

increases expression

Aspirin results in increased expression of STAMBP mRNA

NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation
decreases expression

IL6 protein inhibits the reaction [Aspirin results in decreased expression of STAT3 protein modified form]
Aspirin results in decreased phosphorylation of STAT3 protein
Aspirin results in decreased expression of STAT3 mRNA; Aspirin results in decreased expression of STAT3 protein modified form

PMID:11906190 PMID:19595669 PMID:20886344

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5B

decreases expression

Aspirin results in decreased expression of STAT5B mRNA

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

signal transducer and activator of transcription 6

multiple interactions

Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Aspirin inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

serine/threonine kinase 10

affects response to substance

STK10 polymorphism affects the susceptibility to Aspirin

NCBI chr10:17,117,860...17,212,065
Ensembl chr10:17,117,878...17,212,061

G

striatin 4

increases expression

Aspirin results in increased expression of STRN4 mRNA

NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858

G

syntaxin binding protein 1

affects expression

Aspirin affects the expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

small ubiquitin-like modifier 1

decreases expression

Aspirin results in decreased expression of SUMO1 mRNA

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

G

small ubiquitin-like modifier 3

increases expression

Aspirin results in increased expression of SUMO3 mRNA

NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877
Ensembl chr20:11,007,148...11,020,877

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Sad1 and UNC84 domain containing 2

increases expression

Aspirin results in increased expression of SUN2 mRNA

NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553

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transforming, acidic coiled-coil containing protein 3

decreases expression

Aspirin results in decreased expression of TACC3 mRNA

NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219

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TATA-box binding protein associated factor 6

decreases expression

Aspirin results in decreased expression of TAF6 mRNA

NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247

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transporter 2, ATP binding cassette subfamily B member

affects response to substance

TAP2 SNP affects the susceptibility to Aspirin

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

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TBC1 domain family, member 10b

increases expression

Aspirin results in increased expression of TBC1D10B mRNA

NCBI chr 1:181,814,972...181,826,628
Ensembl chr 1:181,814,972...181,826,628

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transducin (beta)-like 1 X-linked

decreases expression

Aspirin results in decreased expression of TBL1X mRNA

NCBI chr X:41,574,558...41,731,117
Ensembl chr X:41,576,047...41,731,101

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T-box transcription factor 21

affects response to substance

TBX21 SNP affects the susceptibility to Aspirin

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

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thromboxane A2 receptor

affects response to substance
decreases response to substance

TBXA2R gene SNP affects the susceptibility to Aspirin; TBXA2R polymorphism affects the susceptibility to Aspirin
TBXA2R SNP results in decreased susceptibility to Aspirin

PMID:17245331 PMID:20485159 PMID:21070398

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

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thromboxane A synthase 1

affects response to substance

TBXAS1 polymorphism affects the susceptibility to Aspirin

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

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transcription factor 4

multiple interactions
decreases activity

TCF4 protein promotes the reaction [Aspirin results in increased susceptibility to TNFSF10 protein]
Aspirin results in decreased activity of TCF4 protein

PMID:11593435 PMID:21171083

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

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T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3

increases expression

Aspirin results in increased expression of TCIRG1 mRNA

NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742

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telomerase reverse transcriptase

increases expression

Aspirin results in increased expression of TERT mRNA

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

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transferrin

multiple interactions

Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of TF protein]

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

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transcription factor A, mitochondrial

multiple interactions

Aspirin inhibits the reaction [Cisplatin results in decreased expression of TFAM protein]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

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transcription factor binding to IGHM enhancer 3

decreases expression

Aspirin results in decreased expression of TFE3 mRNA

NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571

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trefoil factor 2

multiple interactions

[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TFF2 mRNA

NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619

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trafficking from ER to golgi regulator

increases expression

Aspirin results in increased expression of TFG mRNA

NCBI chr11:43,885,542...43,911,976
Ensembl chr11:43,885,661...43,911,976

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transforming growth factor alpha

multiple interactions
decreases expression

[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA
Aspirin results in decreased expression of TGFA mRNA

PMID:9726391 PMID:12231391

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

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transforming growth factor, beta 1

decreases expression
multiple interactions
increases response to substance

Aspirin results in decreased expression of TGFB1 mRNA
Aspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
TGFB1 promoter SNP results in increased susceptibility to Aspirin

PMID:12566377 PMID:14586741 PMID:15928584 PMID:19138248 PMID:21360558

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

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TGFB-induced factor homeobox 1

decreases expression

Aspirin results in decreased expression of TGIF1 mRNA

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

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thrombospondin 1

increases expression
multiple interactions

Aspirin results in increased expression of THBS1 mRNA
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of THBS1 protein]

PMID:15928584 PMID:17303692

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

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translocase of inner mitochondrial membrane 17b

increases expression

Aspirin results in increased expression of TIMM17B mRNA

NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416

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TIMP metallopeptidase inhibitor 1

increases expression
increases secretion

Aspirin results in increased expression of TIMP1 mRNA
Aspirin results in increased secretion of TIMP1 protein

PMID:18971601 PMID:19462226

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

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TIMP metallopeptidase inhibitor 2

decreases expression
increases expression

Aspirin results in decreased expression of TIMP2 mRNA
Aspirin results in increased expression of TIMP2 mRNA

PMID:15928584 PMID:18971601

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

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toll-like receptor 3

affects response to substance

TLR3 polymorphism affects the susceptibility to Aspirin

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

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transmembrane p24 trafficking protein 9

increases expression

Aspirin results in increased expression of TMED9 mRNA

NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176

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transmembrane protein 205

increases expression

Aspirin results in increased expression of TMEM205 mRNA

NCBI chr 8:20,452,092...20,458,011
Ensembl chr 8:20,452,092...20,457,828

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tropomodulin 4

increases expression

Aspirin results in increased expression of TMOD4 mRNA

NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540

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thymosin beta 4, X-linked

increases expression

Aspirin results in increased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

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tumor necrosis factor

multiple interactions
increases expression
decreases expression
affects secretion
affects response to substance

[Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Aspirin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein]; Aspirin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Aspirin promotes the reaction [Salmonella Vaccines results in increased expression of TNF protein]
Aspirin results in increased expression of TNF protein
[Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Aspirin promotes the reaction [Acetic Acid results in increased expression of TNF protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of TNF protein]; lipopolysaccharide, Helicobacter pylori inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein]
Aspirin results in decreased expression of TNF mRNA
[Aspirin co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Aspirin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Aspirin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; SOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
Aspirin affects the secretion of TNF protein
TNF gene SNP affects the susceptibility to Aspirin; TNF polymorphism affects the susceptibility to Aspirin

PMID:9281604 PMID:10328874 PMID:11376495 PMID:11826407 PMID:12045164 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

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TNF alpha induced protein 6

increases expression
decreases expression

Aspirin results in increased expression of TNFAIP6 mRNA
Aspirin results in decreased expression of TNFAIP6 mRNA

PMID:15928584 PMID:32816093

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

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TNF receptor superfamily member 10b

multiple interactions

Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNFRSF10B mRNA]

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

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TNF receptor superfamily member 1A

increases expression

Aspirin results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

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TNF receptor superfamily member 25

increases expression

Aspirin results in increased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

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TNF superfamily member 10

multiple interactions
increases response to substance

[Aspirin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein; [Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of BID protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of CASP8 protein; Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; TCF4 protein promotes the reaction [Aspirin results in increased susceptibility to TNFSF10 protein]
Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNFSF10 mRNA]

PMID:16199534 PMID:18483385 PMID:20043115 PMID:21171083

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

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troponin I3, cardiac type

increases expression

Aspirin results in increased expression of TNNI3 mRNA

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

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tensin 3

increases expression

Aspirin results in increased expression of TNS3 mRNA

NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998

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transducer of ErbB-2.1

decreases expression

Aspirin results in decreased expression of TOB1 mRNA

NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215

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DNA topoisomerase III beta

increases expression

Aspirin results in increased expression of TOP3B mRNA

NCBI chr11:84,097,018...84,125,474
Ensembl chr11:84,097,026...84,125,392

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tumor protein p53

increases acetylation
multiple interactions
increases expression

Aspirin results in increased acetylation of TP53 protein
Aspirin inhibits the reaction [sodium bichromate results in increased expression of TP53 protein]
Aspirin results in increased expression of TRP53 protein
Aspirin results in increased expression of TP53 protein

PMID:10942736 PMID:12535653 PMID:16880202 PMID:19212664

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

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tumor protein p53 inducible protein 13

increases expression

Aspirin results in increased expression of TP53I13 mRNA

NCBI chr10:62,356,722...62,363,122
Ensembl chr10:62,356,722...62,361,343

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TPD52 like 2

decreases expression

Aspirin results in decreased expression of TPD52L2 mRNA

NCBI chr 3:168,598,449...168,618,201
Ensembl chr 3:168,594,609...168,619,762

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transformer 2 beta

increases expression
decreases expression

Aspirin results in increased expression of TRA2B mRNA
Aspirin results in decreased expression of TRA2B mRNA

PMID:12800193 PMID:15928584

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

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TNF receptor associated factor 6

increases expression

Aspirin results in increased expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

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trafficking protein particle complex subunit 6A

increases expression

Aspirin results in increased expression of TRAPPC6A mRNA

NCBI chr 1:79,158,587...79,165,502
Ensembl chr 1:79,158,529...79,165,493

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tripartite motif-containing 21

decreases expression

Aspirin results in decreased expression of TRIM21 mRNA

NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440

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tRNA isopentenyltransferase 1

increases expression

Aspirin results in increased expression of TRIT1 mRNA

NCBI chr 5:135,293,472...135,341,522
Ensembl chr 5:135,295,330...135,338,764

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transient receptor potential cation channel, subfamily M, member 4

increases expression

Aspirin results in increased expression of TRPM4 mRNA

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

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translin-associated factor X

increases expression

Aspirin results in increased expression of TSNAX mRNA

NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878

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tetraspanin 3

decreases expression

Aspirin results in decreased expression of TSPAN3 mRNA

NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880

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tubulin, alpha 1A

decreases expression

Aspirin results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

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thioredoxin reductase 1

decreases expression

Aspirin results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

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tyrosine kinase 2

decreases expression

Aspirin results in decreased expression of TYK2 mRNA

NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044

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thymidine phosphorylase

multiple interactions
decreases expression

Aspirin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TYMP mRNA]
Aspirin results in decreased expression of TYMP mRNA

PMID:14573775 PMID:15456535

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

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ubiquitin-like modifier activating enzyme 2

increases expression

Aspirin results in increased expression of UBA2 mRNA

NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682

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ubiquitin-conjugating enzyme E2A

increases expression

Aspirin results in increased expression of UBE2A mRNA

NCBI chr X:116,114,339...116,125,076
Ensembl chr X:116,113,875...116,125,070

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ubiquitin-conjugating enzyme E2B

increases expression

Aspirin results in increased expression of UBE2B mRNA

NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665

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ubiquitin-conjugating enzyme E2K

increases expression

Aspirin results in increased expression of UBE2K mRNA

NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630

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ubiquitin protein ligase E3C

affects response to substance

UBE3C polymorphism affects the susceptibility to Aspirin

NCBI chr 4:5,648,932...5,749,922
Ensembl chr 4:5,648,690...5,750,011

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ubiquitination factor E4A

increases expression

Aspirin results in increased expression of UBE4A mRNA

NCBI chr 8:45,236,022...45,278,129
Ensembl chr 8:45,236,026...45,278,038

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ubiquitin domain containing 1

increases expression

Aspirin results in increased expression of UBTD1 mRNA

NCBI chr 1:240,794,570...240,845,795
Ensembl chr 1:240,794,570...240,845,788