|
G
|
Oat
|
ornithine aminotransferase
|
multiple interactions
|
EXP
|
Rhamnose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
|
CTD |
PMID:2827574 |
|
NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754
|
|
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G
|
Abcb11
|
ATP binding cassette subfamily B member 11
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of ABCB11 mRNA; baohuoside I results in decreased expression of ABCB11 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
|
|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of ABCC2 mRNA; baohuoside I results in decreased expression of ABCC2 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
decreases phosphorylation multiple interactions
|
ISO
|
baohuoside I results in decreased phosphorylation of AKT1 protein baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:25119583 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Akt1s1
|
AKT1 substrate 1
|
multiple interactions decreases phosphorylation
|
ISO
|
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] baohuoside I results in decreased phosphorylation of AKT1S1 protein
|
CTD |
PMID:25119583 |
|
NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:104,469,803...104,476,167
|
|
G
|
Alpl
|
alkaline phosphatase, biomineralization associated
|
increases expression increases secretion
|
EXP ISO
|
baohuoside I results in increased expression of ALPL mRNA baohuoside I results in increased secretion of ALPL protein
|
CTD |
PMID:17764702 PMID:35802278 |
|
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
increases expression
|
ISO
|
baohuoside I results in increased expression of BAX protein
|
CTD |
PMID:22687635 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of BCL2 protein
|
CTD |
PMID:22687635 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bglap
|
bone gamma-carboxyglutamate protein
|
increases expression
|
EXP
|
baohuoside I results in increased expression of BGLAP mRNA
|
CTD |
PMID:17764702 |
|
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
|
|
G
|
Braf
|
B-Raf proto-oncogene, serine/threonine kinase
|
decreases phosphorylation multiple interactions
|
ISO
|
baohuoside I results in decreased phosphorylation of BRAF protein baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]
|
CTD |
PMID:25119583 |
|
NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931
|
|
G
|
Casp3
|
caspase 3
|
increases cleavage increases activity
|
ISO
|
baohuoside I results in increased cleavage of CASP3 protein baohuoside I results in increased activity of CASP3 protein
|
CTD |
PMID:19289254 PMID:22687635 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
increases activity
|
ISO
|
baohuoside I results in increased activity of CASP8 protein
|
CTD |
PMID:19289254 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
increases activity increases cleavage
|
ISO
|
baohuoside I results in increased activity of CASP9 protein baohuoside I results in increased cleavage of CASP9 protein
|
CTD |
PMID:19289254 PMID:22687635 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cdh1
|
cadherin 1
|
multiple interactions increases expression
|
ISO
|
SMO protein inhibits the reaction [baohuoside I results in increased expression of CDH1 mRNA] baohuoside I results in increased expression of CDH1 mRNA; baohuoside I results in increased expression of CDH1 protein
|
CTD |
PMID:32945196 |
|
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
|
|
G
|
Cdh2
|
cadherin 2
|
decreases expression multiple interactions
|
ISO
|
baohuoside I results in decreased expression of CDH2 mRNA; baohuoside I results in decreased expression of CDH2 protein SMO protein inhibits the reaction [baohuoside I results in decreased expression of CDH2 mRNA]
|
CTD |
PMID:32945196 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
|
|
G
|
Col1a2
|
collagen type I alpha 2 chain
|
increases expression
|
EXP
|
baohuoside I results in increased expression of COL1A2 mRNA
|
CTD |
PMID:17764702 |
|
NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
increases expression
|
ISO
|
baohuoside I results in increased expression of CYP7A1 mRNA; baohuoside I results in increased expression of CYP7A1 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
|
|
G
|
Egf
|
epidermal growth factor
|
multiple interactions
|
ISO
|
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]
|
CTD |
PMID:25119583 |
|
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
|
|
G
|
Egfr
|
epidermal growth factor receptor
|
multiple interactions decreases phosphorylation
|
ISO
|
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] baohuoside I results in decreased phosphorylation of EGFR protein
|
CTD |
PMID:25119583 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
|
|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions
|
ISO
|
baohuoside I binds to and results in increased degradation of ESR1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [baohuoside I results in increased degradation of ESR1 protein]; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein]
|
CTD |
PMID:35802278 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
|
|
G
|
Got1
|
glutamic-oxaloacetic transaminase 1
|
increases secretion
|
ISO
|
baohuoside I results in increased secretion of GOT1 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
increases secretion
|
ISO
|
baohuoside I results in increased secretion of GPT protein
|
CTD |
PMID:35802278 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
decreases phosphorylation
|
ISO
|
baohuoside I results in decreased phosphorylation of GSK3B protein
|
CTD |
PMID:25119583 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions decreases phosphorylation
|
ISO
|
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] baohuoside I results in decreased phosphorylation of MAPK1 protein
|
CTD |
PMID:25119583 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions decreases phosphorylation
|
ISO
|
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] baohuoside I results in decreased phosphorylation of MAPK3 protein
|
CTD |
PMID:25119583 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mir370
|
microRNA 370
|
increases expression
|
ISO
|
baohuoside I results in increased expression of MIR370 mRNA
|
CTD |
PMID:32945196 |
|
NCBI chr 6:134,354,491...134,354,569
Ensembl chr 6:134,354,491...134,354,569
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of MKI67 protein
|
CTD |
PMID:25119583 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions decreases phosphorylation
|
ISO
|
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein] baohuoside I results in decreased phosphorylation of MTOR protein
|
CTD |
PMID:25119583 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of NOS2
|
CTD |
PMID:19289254 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nr0b2
|
nuclear receptor subfamily 0, group B, member 2
|
multiple interactions decreases expression
|
ISO
|
baohuoside I results in decreased expression of and results in decreased activity of and affects the localization of NR0B2 protein; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein] baohuoside I results in decreased expression of NR0B2 mRNA baohuoside I results in decreased expression of NR0B2 mRNA; baohuoside I results in decreased expression of NR0B2 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475
|
|
G
|
Nr1h4
|
nuclear receptor subfamily 1, group H, member 4
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of NR1H4 mRNA; baohuoside I results in decreased expression of NR1H4 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage multiple interactions
|
ISO
|
baohuoside I results in increased cleavage of PARP1 protein Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein]; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]
|
CTD |
PMID:19289254 PMID:22687635 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
G
|
Pdpk1
|
3-phosphoinositide dependent protein kinase-1
|
decreases phosphorylation
|
ISO
|
baohuoside I results in decreased phosphorylation of PDPK1 protein
|
CTD |
PMID:25119583 |
|
NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
decreases expression multiple interactions
|
ISO
|
baohuoside I results in decreased expression of PTGS2 [baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]
|
CTD |
PMID:19289254 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Slc10a1
|
solute carrier family 10 member 1
|
increases expression
|
ISO
|
baohuoside I results in increased expression of SLC10A1 protein baohuoside I results in increased expression of SLC10A1 mRNA; baohuoside I results in increased expression of SLC10A1 protein
|
CTD |
PMID:35802278 |
|
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
|
|
G
|
Slco1a4
|
solute carrier organic anion transporter family, member 1a4
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of SLCO1A1 mRNA
|
CTD |
PMID:35802278 |
|
NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816
|
|
G
|
Smo
|
smoothened, frizzled class receptor
|
decreases expression multiple interactions
|
ISO
|
baohuoside I results in decreased expression of SMO mRNA SMO protein inhibits the reaction [baohuoside I results in decreased expression of CDH2 mRNA]; SMO protein inhibits the reaction [baohuoside I results in decreased expression of VIM mRNA]; SMO protein inhibits the reaction [baohuoside I results in increased expression of CDH1 mRNA]
|
CTD |
PMID:32945196 |
|
NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281
|
|
G
|
Tnfrsf11b
|
TNF receptor superfamily member 11B
|
increases expression
|
EXP
|
baohuoside I results in increased expression of TNFRSF11B mRNA
|
CTD |
PMID:17764702 |
|
NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075
|
|
G
|
Tnfsf11
|
TNF superfamily member 11
|
decreases expression
|
EXP
|
baohuoside I results in decreased expression of TNFSF11 mRNA
|
CTD |
PMID:17764702 |
|
NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
decreases expression
|
ISO
|
baohuoside I results in decreased expression of VEGFA
|
CTD |
PMID:19289254 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
|
|
G
|
Vim
|
vimentin
|
decreases expression multiple interactions
|
ISO
|
baohuoside I results in decreased expression of VIM mRNA; baohuoside I results in decreased expression of VIM protein SMO protein inhibits the reaction [baohuoside I results in decreased expression of VIM mRNA]
|
CTD |
PMID:32945196 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
|
|