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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinolinemonocarboxylic acid
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Accession:CHEBI:26512 term browser browse the term
Definition:Any aromatic carboxylic acid that contains a quinoline moiety that is substituted by one carboxy substituent.
Synonyms:related_synonym: quinolinemonocarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:38773



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7-chlorokynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP 7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
brequinar term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
EXP
ISO
brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of Quinones]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
brequinar results in decreased activity of DHODH protein
CTD PMID:9776318 PMID:9802339 PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
ciprofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Ciprofloxacin results in decreased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Ciprofloxacin results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases export
multiple interactions
increases expression
ISO ABCC4 protein results in increased export of Ciprofloxacin
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin
Ciprofloxacin results in increased expression of ABCC4 mRNA; Ciprofloxacin results in increased expression of ABCC4 protein
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin; Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]
CTD PMID:19307362 PMID:22162766 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ciprofloxacin results in increased expression of ABCG2 protein CTD PMID:26947806 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of AKT1 protein CTD PMID:26947806 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Ciprofloxacin results in increased expression of ALDH1A1 protein CTD PMID:26947806 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases localization
increases expression
ISO BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein]
Ciprofloxacin results in increased expression of BAX protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein] CTD PMID:11832715 PMID:12063570 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Ciprofloxacin results in increased cleavage of and results in increased activity of CASP3 protein
Ciprofloxacin results in increased activity of CASP3 protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 PMID:30273099 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Ciprofloxacin results in increased activity of CASP8 protein CTD PMID:11875713 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO
EXP
Ciprofloxacin results in increased activity of CASP9 protein CTD PMID:11875713 PMID:30273099 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Ciprofloxacin results in decreased activity of CAT protein
Quercetin inhibits the reaction [Ciprofloxacin results in decreased activity of CAT protein]
CTD PMID:25902267 PMID:25929518 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 increases expression ISO Ciprofloxacin results in increased expression of CAV1 protein CTD PMID:26947806 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO
EXP
Ciprofloxacin results in decreased expression of CCNB1 protein
Ciprofloxacin results in increased expression of CCNB1 mRNA; Ciprofloxacin results in increased expression of CCNB1 protein
CTD PMID:10741713 PMID:18512786 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Ciprofloxacin results in decreased expression of CCNE1 protein CTD PMID:10741713 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd44 CD44 molecule increases expression ISO Ciprofloxacin results in increased expression of CD44 protein CTD PMID:26947806 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CDK1 mRNA; Ciprofloxacin results in increased expression of CDK1 protein CTD PMID:18512786 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation ISO Ciprofloxacin results in decreased phosphorylation of CDK2 protein CTD PMID:10741713 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Ciprofloxacin results in decreased expression of CDKN1A; Ciprofloxacin results in decreased expression of CDKN1A protein CTD PMID:10741713 PMID:12063570 PMID:12632069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA] CTD PMID:11052920 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Ciprofloxacin results in increased expression of CSF2 protein CTD PMID:11125792 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Ciprofloxacin results in decreased expression of CXCL2 protein CTD PMID:18197910 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cycs cytochrome c, somatic increases secretion EXP Ciprofloxacin results in increased secretion of CYCS protein CTD PMID:30273099 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine] CTD PMID:11145498 PMID:11151749 PMID:15592331 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Ciprofloxacin results in decreased expression of CYP2C11 mRNA CTD PMID:12621481 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Ciprofloxacin results in decreased activity of CYP3A4 protein CTD PMID:11145498 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Ciprofloxacin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:12621481 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
EXP Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
Ciprofloxacin results in decreased activity of DHODH protein
CTD PMID:9776318 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO Ciprofloxacin results in decreased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases response to substance ISO G6PD protein mutant form results in increased susceptibility to Ciprofloxacin CTD PMID:20127091 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity EXP Ciprofloxacin results in increased activity of GOT1 protein CTD PMID:30273099 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO
EXP
[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]
Ciprofloxacin results in increased activity of GPT protein
CTD PMID:29679711 PMID:30273099 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in increased expression of IFNG mRNA; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]
Ciprofloxacin results in decreased expression of IFNG protein
CTD PMID:16006447 PMID:16968468 PMID:18337667 PMID:19401694 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]
CTD PMID:16939481 PMID:19401694 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Ciprofloxacin results in decreased expression of IL1B protein
CTD PMID:9267955 PMID:11052920 PMID:12428247 PMID:16148020 PMID:18197910 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]] CTD PMID:19401694 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 increases expression ISO Ciprofloxacin results in increased expression of IL3 mRNA; Ciprofloxacin results in increased expression of IL3 protein CTD PMID:11125792 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 decreases expression ISO Ciprofloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:9267955 PMID:11052920 PMID:19401694 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Ciprofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA CTD PMID:29679711 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK1 protein CTD PMID:26947806 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK3 protein CTD PMID:26947806 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Ciprofloxacin results in increased expression of MCL1 protein CTD PMID:32437906 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA CTD PMID:29679711 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA CTD PMID:29679711 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Ciprofloxacin results in decreased expression of MITF protein CTD PMID:32437906 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
Ciprofloxacin results in increased expression of MMP1 mRNA
CTD PMID:12428247 PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Ciprofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
increases activity
EXP Ciprofloxacin results in increased expression of MMP2 mRNA
Ciprofloxacin results in increased activity of MMP2 protein
CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin results in increased expression of MMP3 mRNA
CTD PMID:12428247 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
EXP Ciprofloxacin results in increased activity of MMP9 protein
Ciprofloxacin results in increased expression of MMP9 mRNA
CTD PMID:21058936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Ciprofloxacin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nanog Nanog homeobox increases expression ISO Ciprofloxacin results in increased expression of NANOG protein CTD PMID:26947806 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 decreases response to substance ISO NOD2 gene SNP results in decreased susceptibility to Ciprofloxacin CTD PMID:18371140 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Ciprofloxacin results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ciprofloxacin results in increased cleavage of PARP1 protein CTD PMID:10741713 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ciprofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Plk1 polo-like kinase 1 increases expression EXP Ciprofloxacin results in increased expression of PLK1 protein CTD PMID:18512786 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Ciprofloxacin results in decreased activity of PON1 protein CTD PMID:16880604 PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO Ciprofloxacin results in increased expression of POU5F1 protein CTD PMID:26947806 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prom1 prominin 1 increases expression ISO Ciprofloxacin results in increased expression of PROM1 protein CTD PMID:26947806 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Ciprofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Ciprofloxacin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Ciprofloxacin affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ciprofloxacin affects the localization of SLC2A1 mRNA
Ciprofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc51b SLC51 subunit beta decreases expression ISO Ciprofloxacin results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression ISO Ciprofloxacin results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI1 protein CTD PMID:26947806 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI2 protein CTD PMID:26947806 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SOX2 protein CTD PMID:26947806 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
Ciprofloxacin results in increased expression of TGFB1 mRNA
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TGFB1 mRNA
CTD PMID:18337667 PMID:19371339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TNF mRNA; [irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]
Ciprofloxacin results in decreased expression of TNF protein
CTD PMID:9267955 PMID:11052920 PMID:16939481 PMID:16968468 PMID:18197910 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha affects binding
multiple interactions
ISO Ciprofloxacin binds to TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein]
CTD PMID:21413765 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
JBrowse link
elvitegravir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO elvitegravir results in decreased expression of ALDH1A2 mRNA CTD PMID:34515794 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO elvitegravir results in increased expression of FGF8 mRNA CTD PMID:34515794 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
enrofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity
EXP Selenium inhibits the reaction [enrofloxacin results in decreased activity of CAT protein] CTD PMID:27083143 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Enrofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
gatifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon increases secretion
increases expression
multiple interactions
ISO
EXP
gatifloxacin results in increased secretion of GCG protein
gatifloxacin results in increased expression of GCG protein
[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein; GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]; GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]
Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]
gatifloxacin results in increased expression of GCG mRNA
CTD PMID:23200776 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gcgr glucagon receptor multiple interactions
affects expression
EXP GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA] CTD PMID:23200776 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Ins1 insulin 1 multiple interactions
affects secretion
EXP [Gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein
Gatifloxacin affects the secretion of INS1 protein
CTD PMID:23200776 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO [Gatifloxacin binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Gatifloxacin binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
increases activity
EXP Gatifloxacin results in increased expression of MMP2 mRNA
Gatifloxacin results in increased activity of MMP2 protein
CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity
EXP Gatifloxacin results in increased expression of MMP9 mRNA
Gatifloxacin results in increased activity of MMP9 protein
CTD PMID:21058936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression ISO gatifloxacin results in increased expression of PCSK1 mRNA CTD PMID:23200776 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
kynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCB11 protein results in increased uptake of Taurocholic Acid] CTD PMID:30639138 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] CTD PMID:21483698 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] CTD PMID:21483698 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Kynurenic Acid binds to and results in increased activity of AHR protein
Kynurenic Acid analog results in increased activity of AHR protein; Kynurenic Acid results in increased activity of AHR protein
CTD PMID:20106948 PMID:27020609 PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]
Kynurenic Acid results in increased expression of CYP1A1 mRNA
Kynurenic Acid results in increased activity of CYP1A1 protein
CTD PMID:20106948 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Kynurenic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO Kynurenic Acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA]
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
CTD PMID:20106948 PMID:35123988 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] CTD PMID:20106948 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [Ro 61-8048 results in decreased activity of KMO protein] which results in increased abundance of Kynurenic Acid CTD PMID:30151725 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein] CTD PMID:35123988 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] CTD PMID:35123988 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ocln occludin multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of OCLN protein] CTD PMID:35123988 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; Kynurenic Acid promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein] CTD PMID:35123988 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of TJP1 protein] CTD PMID:35123988 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] CTD PMID:35123988 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
lomefloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO lomefloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
increases activity
EXP lomefloxacin results in increased expression of MMP2 mRNA
lomefloxacin results in increased activity of MMP2 protein
CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity
EXP lomefloxacin results in increased expression of MMP9 mRNA
lomefloxacin results in increased activity of MMP9 protein
CTD PMID:21058936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
moxifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO moxifloxacin results in decreased expression of IFNG protein CTD PMID:16006447 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO moxifloxacin results in decreased secretion of IL1B protein CTD PMID:16352735 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 decreases expression ISO moxifloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO moxifloxacin results in decreased activity of KCNH2 protein CTD PMID:24052561 PMID:27553911 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK1 protein CTD PMID:16352735 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK3 protein CTD PMID:16352735 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases secretion
ISO Moxifloxacin results in increased secretion of MMP1 protein
Moxifloxacin results in decreased secretion of MMP1 protein
CTD PMID:24890593 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression
EXP Moxifloxacin results in increased activity of MMP2 protein
Moxifloxacin results in increased expression of MMP2 mRNA
CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases secretion
increases secretion
ISO Moxifloxacin results in decreased secretion of MMP3 protein
Moxifloxacin results in increased secretion of MMP3 protein
CTD PMID:24890593 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion
increases expression
increases activity
ISO
EXP
Moxifloxacin results in decreased secretion of MMP9 protein
Moxifloxacin results in increased expression of MMP9 mRNA
Moxifloxacin results in increased activity of MMP9 protein
CTD PMID:21058936 PMID:24890593 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Moxifloxacin results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO moxifloxacin results in decreased expression of RELA protein CTD PMID:16352735 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO moxifloxacin results in decreased secretion of TNF protein CTD PMID:16352735 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
norfloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Norfloxacin results in increased expression of AIFM1 protein CTD PMID:32320760 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Norfloxacin results in increased expression of BAD protein CTD PMID:32320760 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Norfloxacin results in increased expression of BAX protein CTD PMID:32320760 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Norfloxacin results in decreased expression of BCL2 protein CTD PMID:32320760 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp2 caspase 2 affects activity ISO Norfloxacin affects the activity of CASP2 protein CTD PMID:32320760 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp8 caspase 8 affects activity ISO Norfloxacin affects the activity of CASP8 protein CTD PMID:32320760 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
EXP Norfloxacin binds to CYP1A2 protein
Norfloxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
CTD PMID:8905919 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
[biphenylylacetic acid co-treated with Norfloxacin] results in increased expression of IL1B mRNA; [biphenylylacetic acid co-treated with Norfloxacin] results in increased expression of IL1B protein
CTD PMID:16148020 PMID:16824509 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Norfloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Norfloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression
EXP Norfloxacin results in increased activity of MMP2 protein
Norfloxacin results in increased expression of MMP2 mRNA
CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity
EXP Norfloxacin results in increased expression of MMP9 mRNA
Norfloxacin results in increased activity of MMP9 protein
CTD PMID:21058936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Norfloxacin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Norfloxacin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
sparfloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression
EXP sparfloxacin results in increased activity of MMP2 protein
sparfloxacin results in increased expression of MMP2 mRNA
CTD PMID:21058936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
EXP sparfloxacin results in increased activity of MMP9 protein
sparfloxacin results in increased expression of MMP9 mRNA
CTD PMID:21058936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
xanthurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO xanthurenic acid binds to and results in increased activity of AHR protein CTD PMID:20106948 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of xanthurenic acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    chemical entity 19913
      molecular entity 19913
        polyatomic entity 19847
          molecule 19755
            cyclic compound 19547
              aromatic compound 19393
                organic aromatic compound 19374
                  quinolines 2665
                    quinolinemonocarboxylic acid 107
                      2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid + 0
                      2-hydroxy-4-quinolone-3-carboxylic acid 0
                      2-oxo-1,2-dihydroquinoline-4-carboxylic acid 0
                      3-oxociprofloxacin 0
                      4-hydroxy-8-methoxyquinaldic acid 0
                      7,8-dihydro-7,8-dihydroxykynurenic acid 0
                      7,8-dihydroxykynurenic acid 0
                      7-chlorokynurenic acid 1
                      AS1842856 0
                      brequinar 1
                      ciprofloxacin + 79
                      elvitegravir + 2
                      enrofloxacin 2
                      garenoxacin 0
                      gatifloxacin + 8
                      kynurenic acid + 19
                      lomefloxacin + 3
                      moxifloxacin 17
                      norfloxacin 15
                      oxolinic acid 0
                      quinaldic acid 0
                      quinclorac + 0
                      quinmerac 0
                      quinoline-4-carboxylic acid 0
                      quinolobactin 0
                      rosoxacin 0
                      sparfloxacin 2
                      sulfociprofloxacin 0
                      xanthurenic acid + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19542
                              organochalcogen compound 19302
                                organooxygen compound 19218
                                  carbon oxoacid 18664
                                    carboxylic acid 18661
                                      aromatic carboxylic acid 12691
                                        quinolinemonocarboxylic acid 107
                                          2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid + 0
                                          2-hydroxy-4-quinolone-3-carboxylic acid 0
                                          2-oxo-1,2-dihydroquinoline-4-carboxylic acid 0
                                          3-oxociprofloxacin 0
                                          4-hydroxy-8-methoxyquinaldic acid 0
                                          7,8-dihydro-7,8-dihydroxykynurenic acid 0
                                          7,8-dihydroxykynurenic acid 0
                                          7-chlorokynurenic acid 1
                                          AS1842856 0
                                          brequinar 1
                                          ciprofloxacin + 79
                                          elvitegravir + 2
                                          enrofloxacin 2
                                          garenoxacin 0
                                          gatifloxacin + 8
                                          kynurenic acid + 19
                                          lomefloxacin + 3
                                          moxifloxacin 17
                                          norfloxacin 15
                                          oxolinic acid 0
                                          quinaldic acid 0
                                          quinclorac + 0
                                          quinmerac 0
                                          quinoline-4-carboxylic acid 0
                                          quinolobactin 0
                                          rosoxacin 0
                                          sparfloxacin 2
                                          sulfociprofloxacin 0
                                          xanthurenic acid + 2
paths to the root