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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyruvate family amino acid
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Accession:CHEBI:26463 term browser browse the term
Definition:An L-α-amino acid which is biosynthesised from pyruvate (i.e. alanine, valine, and leucine). A closed class.
Synonyms:related_synonym: pyruvate family amino acids


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L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine CTD PMID:28558019 NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases abundance
multiple interactions 		ISO IDH2 protein mutant form results in decreased abundance of Alanine
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine] 		CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
L-leucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions ISO Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG5 mRNA]] CTD PMID:31676321 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG7 mRNA]] CTD PMID:31676321 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of BECN1 protein] CTD PMID:31676321 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]] CTD PMID:31676321 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine] CTD PMID:22689575 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Gck glucokinase decreases expression EXP Leucine results in decreased expression of GCK mRNA; Leucine results in decreased expression of GCK protein CTD PMID:19438972 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:31676321 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:31676321 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases expression EXP Leucine results in decreased expression of PDX1 mRNA; Leucine results in decreased expression of PDX1 protein CTD PMID:19438972 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Leucine results in decreased expression of SLC2A2 mRNA; Leucine results in decreased expression of SLC2A2 protein CTD PMID:19438972 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects import ISO SLC3A2 protein affects the import of Leucine CTD PMID:28786956 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc7a8 solute carrier family 7 member 8 affects import ISO SLC7A8 protein affects the import of Leucine CTD PMID:28786956 NCBI chr15:32,153,016...32,212,715
Ensembl chr15:32,153,018...32,212,715 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in decreased expression of SQSTM1 protein] CTD PMID:31676321 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      chemical role 20219
        acceptor 17380
          Bronsted base 17175
            organic amino compound 17164
              amino acid 7910
                proteinogenic amino acid 3627
                  pyruvate family amino acid 15
                    L-alanine 2
                    L-leucine + 13
                    L-valine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbon oxoacid 17678
                                    carboxylic acid 17675
                                      amino acid 7910
                                        alpha-amino acid 6187
                                          L-alpha-amino acid 5685
                                            pyruvate family amino acid 15
                                              L-alanine 2
                                              L-leucine + 13
                                              L-valine + 0
paths to the root