amidine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	amidine	go back to main search page
Accession:	CHEBI:2634	browse the term
Definition:	Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine.
Synonyms:	related_synonym:	Amidines

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Genes (905)

(E)-thiamethoxam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

Thiamethoxam results in increased activity of ALPL protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

annexin A10

increases expression

Thiamethoxam results in increased expression of ANXA10 mRNA

NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648

G

androgen receptor

affects binding

Thiamethoxam binds to AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

decreases expression

Thiamethoxam results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

activating transcription factor 3

increases expression

Thiamethoxam results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression

Thiamethoxam results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Thiamethoxam results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL6, transcription repressor

decreases expression

Thiamethoxam results in decreased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BTG anti-proliferation factor 1

increases expression

Thiamethoxam results in increased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

caspase 3

increases cleavage

Thiamethoxam results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

increases expression
decreases expression
decreases activity
multiple interactions

Thiamethoxam results in increased expression of CAT mRNA
Thiamethoxam results in decreased expression of CAT mRNA
Thiamethoxam results in decreased activity of CAT protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]

PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression

Thiamethoxam results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Thiamethoxam results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

Thiamethoxam results in decreased expression of CYP11A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions

Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
multiple interactions
increases activity

Thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
Thiamethoxam results in increased activity of CYP19A1 protein

PMID:26464060 PMID:28750898 PMID:34181816

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

Thiamethoxam results in decreased expression of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

Thiamethoxam results in decreased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

increases expression

Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

estrogen receptor 1

affects binding
decreases expression

Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein

PMID:31550567 PMID:33533595

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

forkhead box O3

increases expression

Thiamethoxam results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone receptor

decreases expression

Thiamethoxam results in decreased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Thiamethoxam results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

growth arrest and DNA-damage-inducible, beta

decreases expression

Thiamethoxam results in decreased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

glutamic-oxaloacetic transaminase 1

increases activity
multiple interactions

Thiamethoxam results in increased activity of GOT1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

decreases activity

Thiamethoxam results in decreased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression
decreases expression
decreases activity
multiple interactions

Thiamethoxam results in increased expression of GPX1 mRNA
Thiamethoxam results in decreased expression of GPX1 mRNA
Thiamethoxam results in decreased activity of GPX1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]

PMID:30621503 PMID:33533595 PMID:36958429

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions
decreases expression

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein family A (Hsp70) member 5

increases expression

Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 1 beta

multiple interactions
increases expression

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein]
Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases expression

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

Thiamethoxam results in decreased expression of ITPR1 mRNA

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Thiamethoxam results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lactate dehydrogenase A

increases activity
multiple interactions

Thiamethoxam results in increased activity of LDHA protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

luteinizing hormone/choriogonadotropin receptor

decreases expression
multiple interactions
increases expression

Thiamethoxam results in decreased expression of LHCGR protein
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]

PMID:33533595 PMID:34181816

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

leukocyte specific transcript 1

increases expression

Thiamethoxam results in increased expression of LST1 mRNA

NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997

G

melanocortin 4 receptor

decreases expression

Thiamethoxam results in decreased expression of MC4R mRNA

NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719

G

matrix metallopeptidase 7

increases expression

Thiamethoxam results in increased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

nitric oxide synthase 2

decreases activity
multiple interactions
increases expression

Thiamethoxam metabolite results in decreased activity of NOS2 protein
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde

PMID:29197058 PMID:36958429

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

phospholipase C, gamma 2

decreases expression

Thiamethoxam results in decreased expression of PLCG2 mRNA

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

prion protein

increases expression

Thiamethoxam results in increased expression of PRNP mRNA

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

prostaglandin-endoperoxide synthase 2

decreases expression

Thiamethoxam results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

decreases expression

Thiamethoxam results in decreased expression of PTHLH mRNA

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

pentraxin 3

increases expression

Thiamethoxam results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

scavenger receptor class B, member 1

multiple interactions
decreases expression

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

sestrin 2

increases expression

Thiamethoxam results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 22 member 2

decreases activity

Thiamethoxam results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 7 member 11

increases expression

Thiamethoxam results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

superoxide dismutase 1

decreases activity
decreases expression
multiple interactions

Thiamethoxam results in decreased activity of SOD1 protein
Thiamethoxam results in decreased expression of SOD1 mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]

PMID:30621503 PMID:36958429

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

steroidogenic acute regulatory protein

decreases expression
multiple interactions

Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

stanniocalcin 2

increases expression

Thiamethoxam results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

thrombospondin 4

decreases expression

Thiamethoxam results in decreased expression of THBS4 mRNA

NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313

G

thyroid hormone receptor alpha

affects binding

Thiamethoxam binds to THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

tumor necrosis factor

multiple interactions
increases expression

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]
Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin T2, cardiac type

increases secretion
multiple interactions

Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

acetamiprid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases activity
multiple interactions

acetamiprid results in increased activity of ACHE protein
Berberine inhibits the reaction [acetamiprid results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

actin-related protein T2

decreases expression

acetamiprid results in decreased expression of ACTRT2 mRNA

NCBI chr 5:165,236,092...165,237,492
Ensembl chr 5:165,236,086...165,237,629

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

increases expression

acetamiprid results in increased expression of ASAP2 mRNA

NCBI chr 6:40,658,201...40,821,017
Ensembl chr 6:40,657,880...40,820,975

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

increases expression

acetamiprid results in increased expression of B3GNT9 mRNA

NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344

G

butyrylcholinesterase

increases activity

acetamiprid results in increased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

increases expression

acetamiprid results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcium voltage-gated channel subunit alpha1 H

increases expression

acetamiprid results in increased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel auxiliary subunit gamma 1

decreases expression

acetamiprid results in decreased expression of CACNG1 mRNA

NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783

G

caspase recruitment domain family, member 11

increases expression

acetamiprid results in increased expression of CARD11 mRNA

NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112

G

catalase

decreases activity
multiple interactions

acetamiprid results in decreased activity of CAT protein
Berberine inhibits the reaction [acetamiprid results in decreased activity of CAT protein]

PMID:31935421 PMID:37350525

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cholinergic receptor nicotinic alpha 4 subunit

decreases expression

acetamiprid results in decreased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

decreases expression

acetamiprid results in decreased expression of CHRNA7 mRNA

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

decreases expression
multiple interactions

acetamiprid results in decreased expression of CHRNB2
acetamiprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; acetamiprid results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

PMID:16981889 PMID:25459289 PMID:27669271

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cytochrome c oxidase subunit 4i1

decreases expression
multiple interactions

acetamiprid results in decreased expression of COX4I1 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of COX4I1 mRNA]

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

Vitamin E inhibits the reaction [acetamiprid results in decreased expression of CYP11A mRNA]; Vitamin E inhibits the reaction [acetamiprid results in decreased expression of CYP11A protein]
acetamiprid results in decreased expression of CYP11A1 mRNA
acetamiprid results in decreased expression of CYP11A1 mRNA; acetamiprid results in decreased expression of CYP11A1 protein

PMID:28395332 PMID:30103633

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

acetamiprid results in decreased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

doublecortin domain containing 2

increases expression
decreases expression

acetamiprid results in increased expression of DCDC2 mRNA
acetamiprid results in decreased expression of DCDC2 mRNA

NCBI chr17:39,845,952...40,031,781
Ensembl chr17:39,845,952...40,030,743

G

desmin

decreases expression

acetamiprid results in decreased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

coagulation factor II (thrombin) receptor-like 2

increases expression

acetamiprid results in increased expression of F2RL2 mRNA

NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098

G

fatty acid synthase

increases expression
multiple interactions

acetamiprid results in increased expression of FASN protein
Folic Acid inhibits the reaction [acetamiprid results in increased expression of FASN protein]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

acetamiprid results in increased activity of GPT protein
Folic Acid inhibits the reaction [acetamiprid results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

acetamiprid results in decreased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

acetamiprid results in decreased expression of GRIN2A mRNA

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

acetamiprid results in decreased expression of GRIN2B mRNA

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases expression

acetamiprid results in decreased expression of HSD17B1 mRNA

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

heat shock protein family B (small) member 7

decreases expression

acetamiprid results in decreased expression of HSPB7 mRNA

NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266

G

IQ motif containing F1

decreases expression

acetamiprid results in decreased expression of IQCF1 mRNA

NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249

G

luteinizing hormone subunit beta

multiple interactions
increases expression

Vitamin E inhibits the reaction [acetamiprid results in increased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

acetamiprid results in decreased expression of LHR mRNA

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

leiomodin 2

decreases expression

acetamiprid results in decreased expression of LMOD2 mRNA

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

myoglobin

decreases expression

acetamiprid results in decreased expression of MB mRNA

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

minichromosome maintenance domain containing 2

increases expression

acetamiprid results in increased expression of MCMDC2 mRNA

NCBI chr 5:9,291,967...9,337,526
Ensembl chr 5:9,298,101...9,338,300

G

marker of proliferation Ki-67

decreases expression

acetamiprid results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mitochondrially encoded cytochrome c oxidase I

decreases expression
multiple interactions

acetamiprid results in decreased expression of COX1 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of COX1 mRNA]

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions
decreases expression

Berberine inhibits the reaction [acetamiprid results in decreased expression of ND1 mRNA]

NCBI chr MT:2,740...3,694

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

decreases expression
multiple interactions

acetamiprid results in decreased expression of ND2 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of ND2 mRNA]

NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942

G

myogenin

decreases expression

acetamiprid results in decreased expression of MYOG mRNA

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

N-acetylglutamate synthase

decreases expression

acetamiprid results in decreased expression of NAGS mRNA

NCBI chr10:87,098,330...87,102,465
Ensembl chr10:87,098,330...87,102,465

G

NSF attachment protein beta

increases expression

acetamiprid results in increased expression of NAPB mRNA

NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345

G

NADH:ubiquinone oxidoreductase complex assembly factor 2

decreases expression

acetamiprid results in decreased expression of NDUFAF2 mRNA

NCBI chr 2:39,535,680...39,647,378
Ensembl chr 2:39,535,689...39,647,316

G

olfactory receptor family 52 subfamily S member 20

decreases expression

acetamiprid results in decreased expression of OR52S20 mRNA

NCBI chr 1:157,748,451...157,749,422
Ensembl chr 1:157,748,451...157,749,422

G

olfactory receptor family 6 subfamily D member 13B

decreases expression

acetamiprid results in decreased expression of OR6D13B mRNA

NCBI chr 4:149,673,586...149,674,569
Ensembl chr 4:149,669,618...149,678,130

G

PHD finger protein 21B

increases expression

acetamiprid results in increased expression of PHF21B mRNA

NCBI chr 7:115,913,704...115,984,215
Ensembl chr 7:115,915,412...115,984,215

G

placenta associated 8

increases expression

acetamiprid results in increased expression of PLAC8 mRNA

NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264

G

solute carrier family 22 member 1

increases activity

acetamiprid results in increased activity of SLC22A1 protein

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

decreases activity

acetamiprid results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 8

decreases activity

acetamiprid results in decreased activity of SLC22A8 protein

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 45, member 3

increases expression

acetamiprid results in increased expression of SLC45A3 mRNA

NCBI chr13:43,407,293...43,427,588
Ensembl chr13:43,407,293...43,427,588

G

solute carrier organic anion transporter family member 1B2

decreases expression

acetamiprid results in decreased expression of SLCO1B2 mRNA

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

superoxide dismutase 2

decreases expression
multiple interactions

acetamiprid results in decreased expression of SOD2 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of SOD2 mRNA]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

steroidogenic acute regulatory protein

decreases expression
multiple interactions

acetamiprid results in decreased expression of STAR mRNA; acetamiprid results in decreased expression of STAR protein
Vitamin E inhibits the reaction [acetamiprid results in decreased expression of STAR mRNA]; Vitamin E inhibits the reaction [acetamiprid results in decreased expression of STAR protein]

PMID:28395332 PMID:30103633

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

transcriptional adaptor 2B

increases expression

acetamiprid results in increased expression of TADA2B mRNA

NCBI chr14:74,279,286...74,290,758
Ensembl chr14:74,279,217...74,290,755

G

troponin I2, fast skeletal type

decreases expression

acetamiprid results in decreased expression of TNNI2 mRNA

NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560

G

DNA topoisomerase II alpha

decreases expression

acetamiprid results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

increases expression

acetamiprid results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

unc-45 myosin chaperone B

decreases expression

acetamiprid results in decreased expression of UNC45B mRNA

NCBI chr10:67,845,464...67,873,143
Ensembl chr10:67,845,462...67,873,389

amitraz

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 2A

multiple interactions
decreases activity

[Idazoxan binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to amitraz; amitraz binds to and results in increased activity of ADRA2A protein
amitraz results in decreased activity of ADRA2A protein

PMID:10582558 PMID:21251949

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

catalase

decreases expression
multiple interactions

amitraz results in decreased expression of CAT protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

catechol-O-methyltransferase

multiple interactions
affects expression

Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA]; Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein]
amitraz affects the expression of COMT mRNA; amitraz affects the expression of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

amitraz results in increased expression of CYP19A1 mRNA; amitraz results in increased expression of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

amitraz results in increased expression of CYP1A1 protein

PMID:15350676 PMID:31029719

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

amitraz results in increased expression of CYP1A2 protein

PMID:15350676 PMID:31029719

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

amitraz results in increased expression of CYP2B1 protein

PMID:15350676 PMID:31029719

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

amitraz results in increased expression of CYP2B2 protein

PMID:15350676 PMID:31029719

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

amitraz results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

amitraz results in increased expression of CYP3A23-3A1 protein

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

dopamine beta-hydroxylase

multiple interactions
increases expression

Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH protein]
amitraz results in increased expression of DBH mRNA; amitraz results in increased expression of DBH protein

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

dopamine receptor D2

multiple interactions

amitraz inhibits the reaction [Spiperone binds to DRD2 protein]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

glutamate decarboxylase 2

affects expression
multiple interactions

amitraz affects the expression of GAD2 mRNA
[methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; Idazoxan inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; methylhistaprodifen inhibits the reaction [amitraz affects the expression of GAD2 mRNA]

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

glucagon

increases secretion

amitraz results in increased secretion of GCG protein

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutaminase

multiple interactions
increases expression

[methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz results in increased expression of GLS mRNA]; methylhistaprodifen inhibits the reaction [amitraz results in increased expression of GLS mRNA]

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

Kelch-like ECH-associated protein 1

increases expression
multiple interactions

amitraz results in increased expression of KEAP1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

luteinizing hormone subunit beta

increases expression

amitraz results in increased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

monoamine oxidase A

multiple interactions
decreases expression

Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA protein]
amitraz results in decreased expression of MAOA mRNA; amitraz results in decreased expression of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases expression
multiple interactions

amitraz results in decreased expression of MAOB mRNA; amitraz results in decreased expression of MAOB protein
Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB protein]

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

amitraz results in decreased expression of NFE2L2 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

decreases expression
multiple interactions

amitraz results in decreased expression of NQO1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

cytochrome p450 oxidoreductase

increases activity

amitraz results in increased activity of POR protein

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

solute carrier family 22 member 2

multiple interactions

amitraz inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

superoxide dismutase 1

decreases expression
multiple interactions

amitraz results in decreased expression of SOD1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

tyrosine hydroxylase

multiple interactions
increases expression

Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein]
amitraz results in increased expression of TH mRNA; amitraz results in increased expression of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

benzamidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

epidermal growth factor receptor

decreases activity

benzamidine analog results in decreased activity of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

insulin-like growth factor binding protein 5

decreases degradation

benzamidine results in decreased degradation of IGFBP5 protein

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

kallikrein 1

multiple interactions

benzamidine binds to and results in decreased activity of KLK1 protein

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases activity

benzamidine analog results in decreased activity of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

benzamidoxime

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b5 type B

multiple interactions

[CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b5 reductase 3

multiple interactions

[CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime

NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298

G

mitochondrial amidoxime reducing component 1

multiple interactions

[CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime

NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796

G

mitochondrial amidoxime reducing component 2

multiple interactions

[CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime

NCBI chr13:96,362,810...96,397,284

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

UGT1A1 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

UGT1A3 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

clothianidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 13

increases expression

clothianidin results in increased expression of ABCA13 mRNA

NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075

G

ATP binding cassette subfamily B member 6

decreases expression

clothianidin results in decreased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily C member 1

increases expression

clothianidin results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ABCC3 mRNA
clothianidin results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 2

decreases expression

clothianidin results in decreased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily D member 3

decreases expression

clothianidin results in decreased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

ATP binding cassette subfamily G member 1

decreases expression

clothianidin results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

abhydrolase domain containing 4, N-acyl phospholipase B

decreases expression

clothianidin results in decreased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

ABI family member 3 binding protein

decreases expression

clothianidin results in decreased expression of ABI3BP mRNA

NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929

G

acetylcholinesterase

decreases expression

clothianidin results in decreased expression of ACHE mRNA

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adenylate cyclase 2

increases expression

clothianidin results in increased expression of ADCY2 mRNA

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenylate cyclase 4

decreases expression

clothianidin results in decreased expression of ADCY4 mRNA

NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108

G

adhesion G protein-coupled receptor B2

decreases expression

clothianidin results in decreased expression of ADGRB2 mRNA

NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540

G

adhesion G protein-coupled receptor F5

decreases expression

clothianidin results in decreased expression of ADGRF5 mRNA

NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968

G

adhesion G protein-coupled receptor G6

decreases expression

clothianidin results in decreased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adrenoceptor beta 2

decreases expression

clothianidin results in decreased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

AGBL carboxypeptidase 3

increases expression

clothianidin results in increased expression of AGBL3 mRNA

NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188

G

aldo-keto reductase family 1, member B7

increases expression

clothianidin results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

aldehyde dehydrogenase 1 family, member A1

increases expression
multiple interactions

clothianidin results in increased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

archaelysin family metallopeptidase 1

increases expression

clothianidin results in increased expression of AMZ1 mRNA

NCBI chr12:13,886,518...13,924,275
Ensembl chr12:13,891,123...13,909,783

G

ankyrin 3

decreases expression

clothianidin results in decreased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat domain 37

decreases expression

clothianidin results in decreased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

aprataxin and PNKP like factor

increases expression

clothianidin results in increased expression of APLF mRNA

NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633

G

Rho GTPase activating protein 17

increases expression

clothianidin results in increased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

clothianidin results in increased expression of ARHGEF2 mRNA

NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355

G

ARF like GTPase 11

increases expression

clothianidin results in increased expression of ARL11 mRNA

NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596

G

ARF like GTPase 14

increases expression

clothianidin results in increased expression of ARL14 mRNA

NCBI chr 2:153,468,863...153,470,102
Ensembl chr 2:153,468,977...153,469,555

G

ARF like GTPase 6

increases expression

clothianidin results in increased expression of ARL6 mRNA

NCBI chr11:40,711,878...40,738,254
Ensembl chr11:40,712,022...40,737,937

G

ankyrin repeat and SOCS box containing 11

increases expression

clothianidin results in increased expression of ASB11 mRNA

NCBI chr X:30,014,485...30,037,808
Ensembl chr X:29,992,416...30,037,807

G

aspartate beta-hydroxylase domain containing 1

decreases expression

clothianidin results in decreased expression of ASPHD1 mRNA

NCBI chr 1:181,552,968...181,556,902
Ensembl chr 1:181,552,884...181,556,090

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

clothianidin results in decreased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATP23 metallopeptidase and ATP synthase assembly factor homolog

increases expression

clothianidin results in increased expression of XRCC6BP1 mRNA

NCBI chr 7:62,714,752...62,729,893
Ensembl chr 7:62,714,785...62,729,862

G

ATPase plasma membrane Ca2+ transporting 3

decreases expression

clothianidin results in decreased expression of ATP2B3 mRNA

NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775

G

ATPase H+ transporting V0 subunit D2

increases expression

clothianidin results in increased expression of ATP6V0D2 mRNA

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

acyl-CoA wax alcohol acyltransferase 1

increases expression

clothianidin results in increased expression of AWAT1 mRNA

NCBI chr X:65,668,205...65,674,450
Ensembl chr X:65,668,205...65,674,450

G

axin 1

decreases expression

clothianidin results in decreased expression of AXIN1 mRNA

NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615

G

antizyme inhibitor 2

decreases expression

clothianidin results in decreased expression of AZIN2 mRNA

NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397

G

BarH-like homeobox 1

increases expression

clothianidin results in increased expression of BARHL1 mRNA

NCBI chr 3:12,241,327...12,248,649
Ensembl chr 3:12,241,327...12,248,649

G

BCR activator of RhoGEF and GTPase

decreases expression

clothianidin results in decreased expression of BCR mRNA

NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016

G

BICD cargo adaptor 2

decreases expression

clothianidin results in decreased expression of BICD2 mRNA

NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889

G

BRICHOS domain containing 5

decreases expression

clothianidin results in decreased expression of BRICD5 mRNA

NCBI chr10:13,498,726...13,500,259
Ensembl chr10:13,498,381...13,500,259

G

similar to human chromosome 21 open reading frame 140

increases expression

clothianidin results in increased expression of C21ORF140 mRNA

NCBI chr11:31,549,689...31,552,257
Ensembl chr11:31,544,426...31,552,290

G

chromosome 14 C22orf31 homolog

decreases expression

clothianidin results in decreased expression of C22ORF31 mRNA

G

similar to human chromosome 4 open reading frame 36

decreases expression

clothianidin results in decreased expression of C4ORF36 mRNA

NCBI chr14:6,058,581...6,065,848
Ensembl chr14:6,058,581...6,065,847

G

similar to human chromosome 5 open reading frame 46

increases expression

clothianidin results in increased expression of C5ORF46 mRNA

NCBI chr18:35,948,402...35,969,502
Ensembl chr18:35,948,402...35,969,502

G

similar to human chromosome 16 open reading frame 74

decreases expression

clothianidin results in decreased expression of C16ORF74 mRNA

NCBI chr19:48,660,288...48,686,287
Ensembl chr19:48,660,288...48,686,349

G

similar to human chromosome 21 open reading frame 58

decreases expression

clothianidin results in decreased expression of C21ORF58 mRNA

NCBI chr20:12,167,279...12,188,665
Ensembl chr20:12,175,442...12,187,017

G

C2 calcium-dependent domain containing 4B

increases expression

clothianidin results in increased expression of C2CD4B mRNA

NCBI chr 8:68,372,793...68,396,477
Ensembl chr 8:68,384,847...68,396,328

G

similar to human chromosome 5 open reading frame 34

increases expression

clothianidin results in increased expression of C5ORF34 mRNA

NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085

G

calcium voltage-gated channel auxiliary subunit beta 2

decreases expression

clothianidin results in decreased expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

calcium homeostasis modulator 3

increases expression

clothianidin results in increased expression of CALHM3 mRNA

NCBI chr 1:246,043,258...246,048,259
Ensembl chr 1:246,043,258...246,048,259

G

calpain 5

increases expression

clothianidin results in increased expression of CAPN5 mRNA

NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923

G

calcyphosine

decreases expression

clothianidin results in decreased expression of CAPS mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

carbonic anhydrase 3

increases expression

clothianidin results in increased expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

capping protein regulator and myosin 1 linker 1

decreases expression

clothianidin results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

capping protein regulator and myosin 1 linker 3

increases expression

clothianidin results in increased expression of CARMIL3 mRNA

NCBI chr15:28,978,440...28,995,865
Ensembl chr15:28,979,007...28,996,225

G

coiled-coil domain containing 17

decreases expression

clothianidin results in decreased expression of CCDC17 mRNA

NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673

G

coiled-coil domain containing 8

increases expression

clothianidin results in increased expression of CCDC8 mRNA

NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090

G

coiled-coil serine-rich protein 1

decreases expression

clothianidin results in decreased expression of CCSER1 mRNA

NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786

G

CD226 molecule

decreases expression

clothianidin results in decreased expression of CD226 mRNA

NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051

G

CD34 molecule

increases expression

clothianidin results in increased expression of CD34 mRNA

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CD74 molecule

increases expression

clothianidin results in increased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD8 subunit beta

increases expression

clothianidin results in increased expression of CD8B mRNA

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

G

cadherin 8

decreases expression

clothianidin results in decreased expression of CDH8 mRNA

NCBI chr19:5,494,038...5,901,810
Ensembl chr19:5,494,174...5,895,669

G

CMT1A duplicated region transcript 15 like 2

increases expression

clothianidin results in increased expression of CDRT15L2 mRNA

NCBI chr16:11,226,012...11,231,967
Ensembl chr16:11,122,718...11,158,623

G

CEA cell adhesion molecule 6

increases expression

clothianidin results in increased expression of CEACAM6 mRNA

NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668

G

cell migration inducing hyaluronidase 1

increases expression

clothianidin results in increased expression of CEMIP mRNA

NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415

G

carboxylesterase 2H

multiple interactions

[clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cilia and flagella associated protein 107

decreases expression

clothianidin results in decreased expression of CFAP107 mRNA

NCBI chr 5:156,212,385...156,231,481
Ensembl chr 5:156,212,385...156,231,481

G

choline O-acetyltransferase

decreases expression

clothianidin results in decreased expression of CHAT mRNA

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

decreases expression

clothianidin results in decreased expression of CHRNA7 mRNA

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

clothianidin results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; clothianidin results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]
clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:16981889 PMID:21538459 PMID:25459289

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

carbohydrate sulfotransferase 3

increases expression

clothianidin results in increased expression of CHST3 mRNA

NCBI chr20:28,114,386...28,152,046
Ensembl chr20:28,114,404...28,121,807

G

claudin 14

decreases expression

clothianidin results in decreased expression of CLDN14 mRNA

NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171

G

C-type lectin domain family 3, member B

increases expression

clothianidin results in increased expression of CLEC3B mRNA

NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835

G

CKLF-like MARVEL transmembrane domain containing 5

increases expression

clothianidin results in increased expression of CMTM5 mRNA

NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287

G

contactin associated protein 1

decreases expression

clothianidin results in decreased expression of CNTNAP1 mRNA

NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611

G

collagen type XII alpha 1 chain

decreases expression

clothianidin results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type I alpha 1 chain

decreases expression

clothianidin results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type V alpha 2 chain

decreases expression

clothianidin results in decreased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type VI alpha 2 chain

increases expression

clothianidin results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VII alpha 1 chain

decreases expression

clothianidin results in decreased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

coronin 2B

decreases expression

clothianidin results in decreased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

G

cytoplasmic polyadenylation element binding protein 3

decreases expression

clothianidin results in decreased expression of CPEB3 mRNA

NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560

G

copine 4

increases expression

clothianidin results in increased expression of CPNE4 mRNA

NCBI chr 8:105,177,376...105,653,075
Ensembl chr 8:105,177,376...105,653,068

G

CUB and Sushi multiple domains 1

increases expression

clothianidin results in increased expression of CSMD1 mRNA

NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614

G

CXADR, Ig-like cell adhesion molecule

increases expression

clothianidin results in increased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

cytochrome b-245 alpha chain

decreases expression

clothianidin results in decreased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects expression

clothianidin affects the expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

[clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA
clothianidin results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

clothianidin results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

clothianidin results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

clothianidin results in increased expression of CYP3A4 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA
clothianidin results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
increases expression

[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA
clothianidin results in increased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA
clothianidin results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytohesin 4

increases expression

clothianidin results in increased expression of CYTH4 mRNA

NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

clothianidin results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

defensin alpha 5

decreases expression

clothianidin results in decreased expression of DEFA5 mRNA

NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836

G

desmin

increases expression

clothianidin results in increased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

diacylglycerol kinase, delta

increases expression

clothianidin results in increased expression of DGKD mRNA

NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345

G

iodothyronine deiodinase 3

increases expression

clothianidin results in increased expression of DIO3 mRNA

NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660

G

delta like canonical Notch ligand 3

decreases expression

clothianidin results in decreased expression of DLL3 mRNA

NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750

G

dynein axonemal intermediate chain 7

decreases expression

clothianidin results in decreased expression of DNAI7 mRNA

NCBI chr 4:178,143,499...178,179,871
Ensembl chr 4:178,143,500...178,179,980

G

DnaJ heat shock protein family (Hsp40) member C21

increases expression

clothianidin results in increased expression of DNAJC21 mRNA

NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752

G

DnaJ heat shock protein family (Hsp40) member C28

decreases expression

clothianidin results in decreased expression of DNAJC28 mRNA

NCBI chr11:30,855,566...30,858,386
Ensembl chr11:30,853,526...30,858,441

G

DnaJ heat shock protein family (Hsp40) member C5 gamma

increases expression

clothianidin results in increased expression of DNAJC5G mRNA

NCBI chr 6:25,260,087...25,264,251
Ensembl chr 6:25,260,088...25,264,152

G

deoxyribonuclease 1 like 2

decreases expression

clothianidin results in decreased expression of DNASE1L2 mRNA

NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763

G

dynein heavy chain domain 1

decreases expression

clothianidin results in decreased expression of DNHD1 mRNA

NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858

G

docking protein 5

decreases expression

clothianidin results in decreased expression of DOK5 mRNA

NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:159,515,893...159,652,810

G

dihydrouridine synthase 3-like

increases expression

clothianidin results in increased expression of DUS3L mRNA

NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,594,123...1,598,655

G

dual specificity phosphatase 15

increases expression

clothianidin results in increased expression of DUSP15 mRNA

NCBI chr 3:141,408,495...141,419,137
Ensembl chr 3:141,408,498...141,418,999

G

dual specificity phosphatase 16

decreases expression

clothianidin results in decreased expression of DUSP16 mRNA

NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980

G

ELL associated factor 2

decreases expression

clothianidin results in decreased expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

endothelin-converting enzyme 2

increases expression

clothianidin results in increased expression of ECE2 mRNA

NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428

G

EF-hand calcium binding domain 12

decreases expression

clothianidin results in decreased expression of EFCAB12 mRNA

NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560

G

embryonal Fyn-associated substrate

decreases expression

clothianidin results in decreased expression of EFS mRNA

NCBI chr15:28,392,417...28,403,016
Ensembl chr15:28,392,187...28,401,902

G

eukaryotic translation initiation factor 3, subunit F

decreases expression

clothianidin results in decreased expression of EIF3F mRNA

NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204

G

E74 like ETS transcription factor 1

increases expression

clothianidin results in increased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

ELMO domain containing 1

decreases expression

clothianidin results in decreased expression of ELMOD1 mRNA

NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140

G

elastin

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of ELN mRNA
clothianidin results in decreased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

ecto-NOX disulfide-thiol exchanger 1

increases expression

clothianidin results in increased expression of ENOX1 mRNA

NCBI chr15:52,517,833...53,079,752
Ensembl chr15:52,515,178...53,079,749

G

ectonucleotide pyrophosphatase/phosphodiesterase 4

increases expression

clothianidin results in increased expression of ENPP4 mRNA

NCBI chr 9:16,888,923...16,898,860
Ensembl chr 9:16,887,739...16,898,860

G

ependymin related 1

increases expression

clothianidin results in increased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

G

epsin 3

decreases expression

clothianidin results in decreased expression of EPN3 mRNA

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

EGFR pathway substrate 8, signaling adaptor

increases expression

clothianidin results in increased expression of EPS8 mRNA

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

erb-b2 receptor tyrosine kinase 3

increases expression

clothianidin results in increased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

endoplasmic reticulum-golgi intermediate compartment 1

increases expression

clothianidin results in increased expression of ERGIC1 mRNA

NCBI chr10:16,531,192...16,626,974
Ensembl chr10:16,531,194...16,626,957

G

exocyst complex component 4

decreases expression

clothianidin results in decreased expression of EXOC4 mRNA

NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

clothianidin results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor II, thrombin

decreases expression

clothianidin results in decreased expression of F2 mRNA

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

family with sequence similarity 110, member C

increases expression

clothianidin results in increased expression of FAM110C mRNA

NCBI chr 6:47,638,466...47,644,723
Ensembl chr 6:47,638,276...47,644,634

G

family with sequence similarity 131, member A

decreases expression

clothianidin results in decreased expression of FAM131A mRNA

NCBI chr11:80,211,577...80,221,527
Ensembl chr11:80,211,745...80,221,511

G

family with sequence similarity 151, member B

decreases expression

clothianidin results in decreased expression of FAM151B mRNA

NCBI chr 2:23,674,317...23,710,420
Ensembl chr 2:23,674,318...23,710,403

G

family with sequence similarity 169, member A

increases expression

clothianidin results in increased expression of FAM169A mRNA

NCBI chr 2:28,384,162...28,441,361
Ensembl chr 2:28,383,784...28,438,910

G

family with sequence similarity 229, member A

decreases expression

clothianidin results in decreased expression of FAM229A mRNA

NCBI chr 5:141,829,716...141,830,705
Ensembl chr 5:141,828,664...141,830,705

G

Fas ligand

increases expression

clothianidin results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 33

decreases expression

clothianidin results in decreased expression of FBXO33 mRNA

NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669

G

fer-1-like family member 4

decreases expression

clothianidin results in decreased expression of FER1L4 mRNA

NCBI chr 3:144,536,099...144,571,634
Ensembl chr 3:144,536,099...144,571,634

G

Fibroblast growth factor receptor 1

increases expression

clothianidin results in increased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fragile histidine triad diadenosine triphosphatase

increases expression

clothianidin results in increased expression of FHIT mRNA

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

filamin A interacting protein 1

increases expression

clothianidin results in increased expression of FILIP1 mRNA

NCBI chr 8:80,761,283...80,956,556
Ensembl chr 8:80,764,604...80,922,549

G

fat storage-inducing transmembrane protein 1

increases expression

clothianidin results in increased expression of FITM1 mRNA

NCBI chr15:29,064,746...29,066,015
Ensembl chr15:29,064,707...29,066,015

G

folate receptor beta

increases expression

clothianidin results in increased expression of FOLR2 mRNA

NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724

G

FOS like 1, AP-1 transcription factor subunit

increases expression

clothianidin results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box O1

increases expression

clothianidin results in increased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O4

decreases expression

clothianidin results in decreased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

FYN binding protein 1

decreases expression

clothianidin results in decreased expression of FYB1 mRNA

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

gamma-aminobutyric acid type A receptor subunit gamma 1

increases expression

clothianidin results in increased expression of GABRG1 mRNA

NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956

G

gamma-aminobutyric acid type A receptor subunit pi

decreases expression

clothianidin results in decreased expression of GABRP mRNA

NCBI chr10:18,143,031...18,169,595
Ensembl chr10:18,143,038...18,169,516

G

golgi associated kinase 1A

increases expression

clothianidin results in increased expression of FAM198A mRNA

NCBI chr 8:121,610,779...121,643,742
Ensembl chr 8:121,610,787...121,642,942

G

growth differentiation factor 15

increases expression

clothianidin results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth hormone releasing hormone receptor

increases expression

clothianidin results in increased expression of GHRHR mRNA

NCBI chr 4:84,498,159...84,532,851
Ensembl chr 4:84,500,212...84,532,776

G

GLI family zinc finger 1

decreases expression

clothianidin results in decreased expression of GLI1 mRNA

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

G protein subunit gamma transducin 1

decreases expression

clothianidin results in decreased expression of GNGT1 mRNA

NCBI chr 4:32,006,267...32,009,252
Ensembl chr 4:32,006,267...32,009,252

G

glycine N-methyltransferase

decreases expression

clothianidin results in decreased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glypican 6

increases expression

clothianidin results in increased expression of GPC6 mRNA

NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006

G

glycerophosphocholine phosphodiesterase 1

increases expression

clothianidin results in increased expression of GPCPD1 mRNA

NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

increases expression

clothianidin results in increased expression of GPIHBP1 mRNA

NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702

G

G protein-coupled receptor 15 ligand

decreases expression

clothianidin results in decreased expression of GPR15LG mRNA

NCBI chr16:12,868,270...12,875,876
Ensembl chr16:12,868,270...12,875,876

G

glutathione peroxidase 4

decreases expression

clothianidin results in decreased expression of GPX4 protein

PMID:25960033 PMID:33563863

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

GRAM domain containing 1C

decreases expression

clothianidin results in decreased expression of GRAMD1C mRNA

NCBI chr11:56,633,229...56,718,570
Ensembl chr11:56,633,227...56,718,570

G

GRAM domain containing 2A

decreases expression

clothianidin results in decreased expression of GRAMD2A mRNA

NCBI chr 8:60,079,744...60,117,788
Ensembl chr 8:60,080,338...60,115,842

G

GSK3B interacting protein

increases expression

clothianidin results in increased expression of GSKIP mRNA

NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:124,586,070...124,609,100

G

general transcription factor IIIC subunit 5

increases expression

clothianidin results in increased expression of GTF3C5 mRNA

NCBI chr 3:11,893,867...11,914,187
Ensembl chr 3:11,893,875...11,914,180

G

gametocyte specific factor 1-like

increases expression

clothianidin results in increased expression of GTSF1L mRNA

NCBI chr 3:151,736,020...151,738,715
Ensembl chr 3:151,735,997...151,736,863

G

glycophorin C

increases expression

clothianidin results in increased expression of GYPC mRNA

NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204

G

H1.7 linker histone

increases expression

clothianidin results in increased expression of H1-7 mRNA

NCBI chr 7:129,408,521...129,409,888
Ensembl chr 7:129,408,359...129,409,930

G

3-hydroxyacyl-CoA dehydratase 2

increases expression

clothianidin results in increased expression of HACD2 mRNA

NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889

G

HCK proto-oncogene, Src family tyrosine kinase

increases expression

clothianidin results in increased expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

HECT domain E3 ubiquitin protein ligase 2

increases expression

clothianidin results in increased expression of HECTD2 mRNA

NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487

G

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

decreases expression

clothianidin results in decreased expression of HECW2 mRNA

NCBI chr 9:55,359,462...55,753,106
Ensembl chr 9:55,365,203...55,580,327

G

hepatocyte growth factor

decreases expression

clothianidin results in decreased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

HID1 domain containing

decreases expression

clothianidin results in decreased expression of HID1 mRNA

NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041

G

hydroxymethylbilane synthase

increases expression

clothianidin results in increased expression of HMBS mRNA

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

G

HNF1 homeobox B

increases expression

clothianidin results in increased expression of HNF1B mRNA

NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888

G

hepatocyte nuclear factor 4, alpha

increases expression

clothianidin results in increased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

clothianidin results in decreased expression of HNRNPK mRNA

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

intraflagellar transport 70B

decreases expression

clothianidin results in decreased expression of IFT70B mRNA

NCBI chr 3:60,855,809...60,858,380
Ensembl chr 3:60,855,575...60,858,389

G

interleukin 17 receptor E

decreases expression

clothianidin results in decreased expression of IL17RE mRNA

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 18 binding protein

decreases expression

clothianidin results in decreased expression of IL18BP mRNA

NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963

G

interleukin 2 receptor subunit gamma

increases expression

clothianidin results in increased expression of IL2RG mRNA

NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823

G

inner mitochondrial membrane peptidase subunit 1

increases expression

clothianidin results in increased expression of IMMP1L mRNA

NCBI chr 3:92,385,329...92,449,559
Ensembl chr 3:92,385,379...92,452,313

G

inhibin subunit beta A

increases expression

clothianidin results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

inhibitory synaptic factor family member 2B

decreases expression

clothianidin results in decreased expression of INSYN2B mRNA

NCBI chr10:18,916,721...19,023,859
Ensembl chr10:19,003,131...19,022,139

G

iroquois homeobox 5

decreases expression

clothianidin results in decreased expression of IRX5 mRNA

NCBI chr19:14,639,052...14,643,911
Ensembl chr19:14,624,225...14,642,318

G

intersectin 1

decreases expression

clothianidin results in decreased expression of ITSN1 mRNA

NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645

G

Janus kinase 2

decreases expression

clothianidin results in decreased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

lysine acetyltransferase 6B

decreases expression

clothianidin results in decreased expression of KAT6B mRNA

NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316

G

potassium voltage-gated channel subfamily C member 4

increases expression

clothianidin results in increased expression of KCNC4 mRNA

NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233

G

potassium voltage-gated channel subfamily D member 3

decreases expression

clothianidin results in decreased expression of KCND3 mRNA

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

G

potassium two pore domain channel subfamily K member 1

decreases expression

clothianidin results in decreased expression of KCNK1 mRNA

NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724

G

potassium calcium-activated channel subfamily M alpha 1

decreases expression

clothianidin results in decreased expression of KCNMA1 mRNA

PMID:31626844 PMID:35690182

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

kinesin family member 7

increases expression

clothianidin results in increased expression of KIF7 mRNA

NCBI chr 1:133,639,487...133,658,539
Ensembl chr 1:133,640,065...133,658,576

G

kinesin family member C3

increases expression

clothianidin results in increased expression of KIFC3 mRNA

NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

clothianidin results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

kelch domain containing 9

decreases expression

clothianidin results in decreased expression of KLHDC9 mRNA

NCBI chr13:83,790,390...83,794,080
Ensembl chr13:83,790,269...83,793,354

G

karyopherin subunit alpha 6

increases expression

clothianidin results in increased expression of KPNA6 mRNA

NCBI chr 5:141,988,111...142,021,483
Ensembl chr 5:141,991,568...142,021,120

G

keratin 28

increases expression

clothianidin results in increased expression of KRT28 mRNA

NCBI chr10:84,318,352...84,328,693
Ensembl chr10:84,318,543...84,328,643

G

kinase suppressor of ras 1

decreases expression

clothianidin results in decreased expression of KSR1 mRNA

NCBI chr10:63,961,771...64,098,076
Ensembl chr10:63,961,759...64,098,076

G

kyphoscoliosis peptidase

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of KY mRNA
clothianidin results in decreased expression of KY mRNA

NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024

G

L3MBTL histone methyl-lysine binding protein 1

decreases expression

clothianidin results in decreased expression of L3MBTL1 mRNA

NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233

G

galectin 12

increases expression

clothianidin results in increased expression of LGALS12 mRNA

NCBI chr 1:204,832,065...204,842,759
Ensembl chr 1:204,832,065...204,842,759

G

leucine-rich repeat LGI family, member 4

increases expression

clothianidin results in increased expression of LGI4 mRNA

NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874

G

LIF, interleukin 6 family cytokine

decreases expression

clothianidin results in decreased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lens intrinsic membrane protein 2

increases expression

clothianidin results in increased expression of LIM2 mRNA

NCBI chr 1:93,837,597...93,843,769
Ensembl chr 1:93,837,597...93,843,769

G

LON peptidase N-terminal domain and ring finger 1

increases expression

clothianidin results in increased expression of LONRF1 mRNA

NCBI chr16:55,984,572...56,015,156
Ensembl chr16:55,984,463...56,015,156

G

lysyl oxidase

increases expression

clothianidin results in increased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lysophosphatidic acid receptor 1

decreases expression

clothianidin results in decreased expression of LPAR1 mRNA

NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895

G

leucine-rich repeats and immunoglobulin-like domains 1

increases expression

clothianidin results in increased expression of LRIG1 mRNA

NCBI chr 4:127,130,899...127,230,956
Ensembl chr 4:127,130,898...127,231,513

G

leucine rich melanocyte differentiation associated

decreases expression

clothianidin results in decreased expression of LRMDA mRNA

NCBI chr15:1,223,098...2,284,764
Ensembl chr15:1,225,710...2,284,749

G

leucine rich repeat containing 74B

decreases expression

clothianidin results in decreased expression of LRRC74B mRNA

NCBI chr11:83,450,588...83,468,906
Ensembl chr11:83,450,624...83,468,922

G

leucine zipper protein 2

increases expression

clothianidin results in increased expression of LUZP2 mRNA

NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183

G

LysM domain containing 2

decreases expression

clothianidin results in decreased expression of LYSMD2 mRNA

NCBI chr 8:76,378,984...76,394,396
Ensembl chr 8:76,379,219...76,394,654

G

mitogen activated protein kinase 1

increases phosphorylation

clothianidin results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

clothianidin results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

melanin-concentrating hormone receptor 1

increases expression

clothianidin results in increased expression of MCHR1 mRNA

NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032

G

multiple EGF-like-domains 11

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of MEGF11 mRNA
clothianidin results in decreased expression of MEGF11 mRNA

NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061

G

meiosis specific with coiled-coil domain

increases expression

clothianidin results in increased expression of MEIOC mRNA

NCBI chr10:87,628,807...87,646,485
Ensembl chr10:87,628,875...87,646,752

G

methyltransferase 16, RNA N6-adenosine

increases expression

clothianidin results in increased expression of METTL16 mRNA

NCBI chr10:59,640,915...59,697,291
Ensembl chr10:59,640,972...59,687,061

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

clothianidin results in increased expression of MICAL1 mRNA

NCBI chr20:44,974,137...44,986,089
Ensembl chr20:44,974,138...44,986,089

G

MICAL-like 2

decreases expression

clothianidin results in decreased expression of MICALL2 mRNA

NCBI chr12:14,899,188...14,927,949
Ensembl chr12:14,899,157...14,927,946

G

melan-A

increases expression

clothianidin results in increased expression of MLANA mRNA

NCBI chr 1:227,469,537...227,483,343
Ensembl chr 1:227,469,537...227,483,343

G

membrane metallo-endopeptidase

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of MME mRNA
clothianidin results in increased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 10

increases expression

clothianidin results in increased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

membrane spanning 4-domains A2

decreases expression

clothianidin results in decreased expression of MS4A2 mRNA

NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310

G

MSS51 mitochondrial translational activator

decreases expression

clothianidin results in decreased expression of MSS51 mRNA

NCBI chr15:3,805,240...3,819,385
Ensembl chr15:3,807,516...3,819,385

G

mitochondrial ribosome-associated GTPase 1

decreases expression

clothianidin results in decreased expression of MTG1 mRNA

NCBI chr 1:194,931,543...194,944,278
Ensembl chr 1:194,931,531...194,944,277

G

myosin light chain 11

decreases expression

clothianidin results in decreased expression of MYL11 mRNA

NCBI chr 1:181,829,703...181,832,546
Ensembl chr 1:181,829,743...181,832,545

G

myosin, light chain 4

decreases expression

clothianidin results in decreased expression of MYL4 mRNA

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myosin light chain 6

decreases expression

clothianidin results in decreased expression of MYL6 mRNA

NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791

G

myosin IIIB

increases expression

clothianidin results in increased expression of MYO3B mRNA

NCBI chr 3:54,820,225...55,228,518
Ensembl chr 3:54,820,251...55,227,373

G

myogenesis regulating glycosidase

increases expression

clothianidin results in increased expression of MYORG mRNA

NCBI chr 5:56,654,257...56,664,467
Ensembl chr 5:56,648,643...56,664,440

G

myelin transcription factor 1-like

increases expression

clothianidin results in increased expression of MYT1L mRNA

NCBI chr 6:46,164,742...46,564,234
Ensembl chr 6:46,428,150...46,561,671

G

NEDD4 binding protein 2-like 1

increases expression

clothianidin results in increased expression of N4BP2L1 mRNA

NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257

G

NAD synthetase 1

decreases expression

clothianidin results in decreased expression of NADSYN1 mRNA

NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869

G

nuclear autoantigenic sperm protein

decreases expression

clothianidin results in decreased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

neutrophil cytosolic factor 2

increases expression

clothianidin results in increased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

NADH:ubiquinone oxidoreductase subunit A10

increases expression

clothianidin results in increased expression of NDUFA10 mRNA

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

nectin cell adhesion molecule 4

decreases expression

clothianidin results in decreased expression of NECTIN4 mRNA

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

neuronal differentiation 4

decreases expression

clothianidin results in decreased expression of NEUROD4 mRNA

NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030

G

neuronal guanine nucleotide exchange factor

increases expression

clothianidin results in increased expression of NGEF mRNA

NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914

G

nerve growth factor receptor

increases expression

clothianidin results in increased expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

ninein-like

decreases expression

clothianidin results in decreased expression of NINL mRNA

NCBI chr 3:139,748,353...139,814,683
Ensembl chr 3:139,748,355...139,814,622

G

nitric oxide synthase 2

increases expression

clothianidin results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 0, group B, member 2

decreases expression
multiple interactions

clothianidin results in decreased expression of NR0B2 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

netrin 4

decreases expression

clothianidin results in decreased expression of NTN4 mRNA

NCBI chr 7:28,186,611...28,300,390
Ensembl chr 7:28,186,611...28,300,390

G

neurotensin

decreases expression

clothianidin results in decreased expression of NTS mRNA

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

nucleoredoxin-like 2

increases expression

clothianidin results in increased expression of NXNL2 mRNA

NCBI chr17:14,031,151...14,035,897
Ensembl chr17:14,031,153...14,036,189

G

neurexophilin 2

increases expression

clothianidin results in increased expression of NXPH2 mRNA

NCBI chr 3:5,986,175...5,988,525
Ensembl chr 3:5,756,621...5,987,008

G

OCRL, inositol polyphosphate-5-phosphatase

decreases expression

clothianidin results in decreased expression of OCRL mRNA

NCBI chr X:127,089,508...127,140,362
Ensembl chr X:127,089,590...127,140,362

G

olfactory receptor 59

increases expression

clothianidin results in increased expression of OR51E2 mRNA

NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179

G

OTU deubiquitinase 6B

increases expression

clothianidin results in increased expression of OTUD6B mRNA

NCBI chr 5:28,181,992...28,214,486
Ensembl chr 5:28,023,594...28,214,334

G

peptidyl arginine deiminase 4

increases expression

clothianidin results in increased expression of PADI4 mRNA

NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362

G

p21 (RAC1) activated kinase 5

decreases expression

clothianidin results in decreased expression of PAK5 mRNA

PMID:31626844 PMID:35690182

NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930

G

progestin and adipoQ receptor family member 8

decreases expression

clothianidin results in decreased expression of PAQR8 mRNA

NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340

G

phenazine biosynthesis-like protein domain containing 1

decreases expression

clothianidin results in decreased expression of PBLD mRNA

NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614

G

propionyl-CoA carboxylase subunit alpha

decreases expression

clothianidin results in decreased expression of PCCA mRNA

NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266

G

proprotein convertase subtilisin/kexin type 1

decreases expression

clothianidin results in decreased expression of PCSK1 mRNA

NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434

G

phosphodiesterase 10A

decreases expression

clothianidin results in decreased expression of PDE10A mRNA

NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563

G

phosphodiesterase 1C

increases expression

clothianidin results in increased expression of PDE1C mRNA

NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219

G

phosphodiesterase 4D interacting protein

increases expression

clothianidin results in increased expression of PDE4DIP mRNA

NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379

G

PDZ domain containing 7

decreases expression

clothianidin results in decreased expression of PDZD7 mRNA

NCBI chr 1:243,888,295...243,907,778
Ensembl chr 1:243,888,281...243,906,839

G

pellino E3 ubiquitin protein ligase family member 2

decreases expression

clothianidin results in decreased expression of PELI2 mRNA

NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106

G

post-GPI attachment to proteins 6

decreases expression

clothianidin results in decreased expression of PGAP6 mRNA

NCBI chr10:15,138,918...15,148,431
Ensembl chr10:15,138,959...15,148,431

G

progesterone receptor

increases expression

clothianidin results in increased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

PH domain containing endocytic trafficking adaptor 2

increases expression

clothianidin results in increased expression of FAM109B mRNA

NCBI chr 7:113,855,437...113,861,910
Ensembl chr 7:113,857,249...113,861,871

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta

decreases expression

clothianidin results in decreased expression of PIK3C2B mRNA

NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

decreases expression

clothianidin results in decreased expression of PIP5K1C mRNA

NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988

G

phosphatidylinositol-4-phosphate 5-kinase-like 1

decreases expression

clothianidin results in decreased expression of PIP5KL1 mRNA

NCBI chr 3:15,860,493...15,869,264
Ensembl chr 3:15,855,946...15,869,165

G

phospholipase A2 group IIA

increases expression

clothianidin results in increased expression of PLA2G2A mRNA

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

phospholipase B domain containing 1

decreases expression

clothianidin results in decreased expression of PLBD1 mRNA

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277

G

phospholipase C, delta 1

increases expression

clothianidin results in increased expression of PLCD1 mRNA

NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186

G

phospholipase C, delta 3

decreases expression

clothianidin results in decreased expression of PLCD3 mRNA

NCBI chr10:88,026,707...88,048,080
Ensembl chr10:88,026,740...88,048,296

G

phospholipase C-like 1

decreases expression

clothianidin results in decreased expression of PLCL1 mRNA

NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782

G

plasmolipin

increases expression

clothianidin results in increased expression of PLLP mRNA

NCBI chr19:10,315,104...10,335,892
Ensembl chr19:10,315,104...10,335,892

G

patatin-like phospholipase domain containing 1

increases expression

clothianidin results in increased expression of PNPLA1 mRNA

NCBI chr20:6,917,993...6,952,157
Ensembl chr20:6,917,931...6,952,375

G

RNA polymerase II subunit M

decreases expression

clothianidin results in decreased expression of POLR2M mRNA

NCBI chr 8:72,131,992...72,139,423
Ensembl chr 8:72,131,530...72,243,036

G

protein phosphatase 1, regulatory subunit 3C

increases expression

clothianidin results in increased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 3 catalytic subunit gamma

increases expression

clothianidin results in increased expression of PPP3CC mRNA

NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832

G

proteoglycan 3, pro eosinophil major basic protein 2

increases expression

clothianidin results in increased expression of PRG3 mRNA

NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

clothianidin results in decreased expression of PARK2 mRNA

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin receptor

decreases expression

clothianidin results in decreased expression of PRLR mRNA

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

prion like protein doppel

increases expression

clothianidin results in increased expression of PRND mRNA

NCBI chr 3:119,213,462...119,218,742
Ensembl chr 3:119,213,429...119,218,745

G

proline dehydrogenase 2

increases expression

clothianidin results in increased expression of PRODH2 mRNA

NCBI chr 1:85,753,558...85,767,165
Ensembl chr 1:85,753,644...85,767,162

G

proline rich 5 like

increases expression

clothianidin results in increased expression of PRR5L mRNA

NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763

G

peroxiredoxin like 2B

decreases expression

clothianidin results in decreased expression of PRXL2B mRNA

NCBI chr 5:165,462,610...165,465,213

G

presenilin 1

decreases expression

clothianidin results in decreased expression of PSEN1 mRNA

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

proteasome 26S subunit, ATPase 6

decreases expression

clothianidin results in decreased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

prostaglandin F receptor

decreases expression

clothianidin results in decreased expression of PTGFR mRNA

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

protein tyrosine phosphatase, non-receptor type 3

increases expression

clothianidin results in increased expression of PTPN3 mRNA

NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443

G

protein tyrosine phosphatase, receptor type, B

decreases expression

clothianidin results in decreased expression of PTPRB mRNA

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

protein tyrosine phosphatase, receptor type, O

decreases expression

clothianidin results in decreased expression of PTPRO mRNA

NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771

G

glutaminyl-peptide cyclotransferase

increases expression

clothianidin results in increased expression of QPCT mRNA

NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711

G

recombination activating 1

decreases expression

clothianidin results in decreased expression of RAG1 mRNA

NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291

G

Rap guanine nucleotide exchange factor like 1

decreases expression

clothianidin results in decreased expression of RAPGEFL1 mRNA

NCBI chr10:83,793,711...83,810,373
Ensembl chr10:83,793,694...83,810,371

G

RNA binding motif protein 26

decreases expression

clothianidin results in decreased expression of RBM26 mRNA

NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118

G

RNA binding motif, single stranded interacting protein 1

decreases expression

clothianidin results in decreased expression of RBMS1 mRNA

NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376

G

regenerating family member 3 gamma

increases expression

clothianidin results in increased expression of REG3G mRNA

NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723

G

Rieske (Fe-S) domain containing

decreases expression

clothianidin results in decreased expression of RFESD mRNA

NCBI chr 2:5,495,067...5,521,095
Ensembl chr 2:5,505,756...5,522,449

G

regulatory subunit of type II PKA R-subunit domain containing 1

decreases expression

clothianidin results in decreased expression of RIIAD1 mRNA

NCBI chr 2:182,099,924...182,110,544
Ensembl chr 2:182,101,795...182,110,319

G

Rho family GTPase 1

increases expression

clothianidin results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

RP1 like 1

increases expression

clothianidin results in increased expression of RP1L1 mRNA

NCBI chr15:38,259,907...38,271,269
Ensembl chr15:38,259,928...38,270,316

G

ribosomal protein S29

increases expression

clothianidin results in increased expression of RPS29 mRNA

NCBI chr 6:87,635,229...87,636,627
Ensembl chr 6:87,635,230...87,636,636
Ensembl chr13:87,635,230...87,636,636

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

clothianidin results in increased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

RT1 class II, locus Bb

increases expression

clothianidin results in increased expression of HLA-DQB1 mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

S100 calcium binding protein A5

decreases expression

clothianidin results in decreased expression of S100A5 mRNA

NCBI chr 2:176,095,332...176,099,546
Ensembl chr 2:176,097,539...176,099,546

G

SAM and SH3 domain containing 3

increases expression

clothianidin results in increased expression of SASH3 mRNA

NCBI chr X:127,326,815...127,341,521
Ensembl chr X:127,326,859...127,341,519

G

sodium voltage-gated channel alpha subunit 7

decreases expression

clothianidin results in decreased expression of SCN7A mRNA

NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256

G

sodium channel epithelial 1 subunit beta

increases expression

clothianidin results in increased expression of SCNN1B mRNA

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

semaphorin 3F

decreases expression

clothianidin results in decreased expression of SEMA3F mRNA

NCBI chr 8:108,357,629...108,386,569
Ensembl chr 8:108,357,629...108,387,083

G

stress-associated endoplasmic reticulum protein 1

decreases expression

clothianidin results in decreased expression of SERP1 mRNA

NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116

G

serpin family A member 3N

decreases expression

clothianidin results in decreased expression of SERPINA3N mRNA

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family C member 1

decreases expression

clothianidin results in decreased expression of SERPINC1 mRNA

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

decreases expression

clothianidin results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sarcoglycan, delta

increases expression

clothianidin results in increased expression of SGCD mRNA

NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840

G

serum/glucocorticoid regulated kinase 2

decreases expression

clothianidin results in decreased expression of SGK2 mRNA

NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480

G

SH3 domain and tetratricopeptide repeats 1

increases expression

clothianidin results in increased expression of SH3TC1 mRNA

NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995

G

signal-induced proliferation-associated 1 like 2

increases expression

clothianidin results in increased expression of SIPA1L2 mRNA

NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428

G

solute carrier family 14 member 1 (Kidd blood group)

decreases expression

clothianidin results in decreased expression of SLC14A1 mRNA

NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146

G

solute carrier family 17 member 7

decreases expression

clothianidin results in decreased expression of SLC17A7 mRNA

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 22 member 2

decreases activity

clothianidin results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 6

decreases activity

clothianidin results in decreased activity of SLC22A6 protein

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

clothianidin results in decreased activity of SLC22A8 protein

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 28 member 1

increases expression

clothianidin results in increased expression of SLC28A1 mRNA

NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464

G

solute carrier family 38, member 9

decreases expression

clothianidin results in decreased expression of SLC38A9 mRNA

NCBI chr 2:44,291,637...44,374,897
Ensembl chr 2:44,291,989...44,368,955

G

solute carrier family 45, member 2

decreases expression

clothianidin results in decreased expression of SLC45A2 mRNA

NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317

G

solute carrier family 47 member 2

decreases activity

clothianidin results in decreased activity of SLC47A2 protein

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 48 member 1

increases expression

clothianidin results in increased expression of SLC48A1 mRNA

NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024

G

solute carrier family 6 member 1

decreases expression
multiple interactions

clothianidin results in decreased expression of SLC6A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

solute carrier organic anion transporter family, member 1c1

increases expression

clothianidin results in increased expression of SLCO1C1 mRNA

NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289

G

sphingomyelin phosphodiesterase 3

decreases expression

clothianidin results in decreased expression of SMPD3 mRNA

NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749

G

sorbin and SH3 domain containing 1

increases expression

clothianidin results in increased expression of SORBS1 mRNA

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

spermatogenesis associated 3

increases expression

clothianidin results in increased expression of SPATA3 mRNA

NCBI chr 9:86,660,352...86,672,272
Ensembl chr 9:86,659,784...86,672,272

G

spire-type actin nucleation factor 2

decreases expression

clothianidin results in decreased expression of SPIRE2 mRNA

NCBI chr19:51,373,368...51,411,920
Ensembl chr19:51,373,228...51,411,920

G

steroid 5 alpha-reductase 2

increases expression

clothianidin results in increased expression of SRD5A2 mRNA

NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112

G

SCO-spondin

decreases expression

clothianidin results in decreased expression of SSPOP mRNA

NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412

G

SH3 and cysteine rich domain 2

increases expression

clothianidin results in increased expression of STAC2 mRNA

NCBI chr10:83,032,418...83,048,260
Ensembl chr10:83,032,417...83,048,260

G

STEAP2 metalloreductase

increases expression

clothianidin results in increased expression of STEAP2 mRNA

NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791

G

sushi domain containing 4

increases expression

clothianidin results in increased expression of SUSD4 mRNA

NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750

G

synaptonemal complex protein 2

decreases expression

clothianidin results in decreased expression of SYCP2 mRNA

NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789

G

synaptopodin

decreases expression

clothianidin results in decreased expression of SYNPO mRNA

NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126

G

tachykinin receptor 1

increases expression

clothianidin results in increased expression of TACR1 mRNA

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

TAFA chemokine like family member 2

decreases expression

clothianidin results in decreased expression of FAM19A2 mRNA

NCBI chr 7:58,942,598...59,418,640
Ensembl chr 7:58,942,610...59,417,299

G

TAFA chemokine like family member 5

increases expression

clothianidin results in increased expression of FAM19A5 mRNA

NCBI chr 7:118,613,731...118,835,016
Ensembl chr 7:118,613,889...118,834,353

G

T-box transcription factor 2

increases expression

clothianidin results in increased expression of TBX2 mRNA

NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529

G

t-complex protein 10b

increases expression

clothianidin results in increased expression of TCP10L2 mRNA

NCBI chr 1:52,937,823...52,961,307
Ensembl chr 1:52,937,917...52,961,307

G

tectonin beta-propeller repeat containing 1

decreases expression

clothianidin results in decreased expression of TECPR1 mRNA

NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611

G

TEF transcription factor, PAR bZIP family member

increases expression

clothianidin results in increased expression of TEF mRNA

NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783

G

transforming growth factor, beta induced

increases expression

clothianidin results in increased expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

transglutaminase 5

decreases expression

clothianidin results in decreased expression of TGM5 mRNA

NCBI chr 3:108,008,087...108,044,013
Ensembl chr 3:108,008,143...108,043,976

G

thyroid hormone responsive

decreases expression

clothianidin results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

TIR domain containing adaptor molecule 1

increases expression

clothianidin results in increased expression of TICAM1 mRNA

NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147

G

TRAF-interacting protein with forkhead-associated domain

increases expression

clothianidin results in increased expression of TIFA mRNA

NCBI chr 2:216,257,926...216,267,635
Ensembl chr 2:216,234,774...216,267,841

G

TLC domain containing 4

increases expression

clothianidin results in increased expression of TLCD4 mRNA

NCBI chr 2:209,284,873...209,360,156
Ensembl chr 2:209,289,732...209,341,353

G

toll-like receptor 2

increases expression

clothianidin results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

T-cell leukemia, homeobox 3

decreases expression

clothianidin results in decreased expression of TLX3 mRNA

NCBI chr10:17,789,706...17,792,207
Ensembl chr10:17,790,053...17,792,207

G

transmembrane protein 273

increases expression

clothianidin results in increased expression of TMEM273 mRNA

NCBI chr16:8,049,565...8,081,981
Ensembl chr16:8,049,669...8,081,981

G

transmembrane protein 38a

decreases expression

clothianidin results in decreased expression of TMEM38A mRNA

NCBI chr16:17,258,160...17,274,204
Ensembl chr16:17,258,164...17,273,415

G

transmembrane protein 71

decreases expression

clothianidin results in decreased expression of TMEM71 mRNA

NCBI chr 7:98,276,975...98,323,161
Ensembl chr 7:98,276,975...98,315,858

G

thiol methyltransferase 1A

decreases expression

clothianidin results in decreased expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tumor necrosis factor

multiple interactions

clothianidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; clothianidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

decreases expression

clothianidin results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

tenascin XB

decreases expression

clothianidin results in decreased expression of TNXB mRNA

G

tropomyosin 1

increases expression

clothianidin results in increased expression of TPM1 mRNA

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

Tnf receptor associated factor 4

increases expression

clothianidin results in increased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

TNF receptor associated factor 6

decreases expression

clothianidin results in decreased expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

trafficking protein particle complex subunit 4

increases expression

clothianidin results in increased expression of TRAPPC4 mRNA

NCBI chr 8:44,729,458...44,733,285
Ensembl chr 8:44,725,331...44,733,491

G

tripartite motif-containing 37

decreases expression

clothianidin results in decreased expression of TRIM37 mRNA

NCBI chr10:71,943,384...72,075,563
Ensembl chr10:71,943,375...72,075,558

G

tRNA methyltransferase 44

increases expression

clothianidin results in increased expression of TRMT44 mRNA

NCBI chr14:75,175,331...75,204,291
Ensembl chr14:75,182,029...75,200,147

G

testis-specific serine kinase 6

decreases expression

clothianidin results in decreased expression of TSSK6 mRNA

NCBI chr16:19,523,626...19,526,074
Ensembl chr16:19,517,334...19,526,090

G

tetratricopeptide repeat domain 28

decreases expression

clothianidin results in decreased expression of TTC28 mRNA

NCBI chr12:45,342,986...45,783,968
Ensembl chr12:45,345,399...45,783,547

G

tetratricopeptide repeat domain 33

decreases expression

clothianidin results in decreased expression of TTC33 mRNA

NCBI chr 2:54,279,906...54,326,851
Ensembl chr 2:54,279,997...54,323,871

G

tetratricopeptide repeat domain 8

decreases expression

clothianidin results in decreased expression of TTC8 mRNA

NCBI chr 6:118,198,186...118,252,422
Ensembl chr 6:118,198,201...118,252,418

G

tubulin gamma complex component 3

increases expression

clothianidin results in increased expression of TUBGCP3 mRNA

NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499

G

thioredoxin domain containing 2

increases expression

clothianidin results in increased expression of TXNDC2 mRNA

NCBI chr 9:105,230,575...105,235,131
Ensembl chr 9:105,230,578...105,235,126

G

ubiquitin associated protein 1-like

decreases expression
increases expression

clothianidin results in decreased expression of UBAP1L mRNA
clothianidin results in increased expression of UBAP1L mRNA

PMID:29044138 PMID:31626844

NCBI chr 8:65,877,488...65,897,593
Ensembl chr 8:65,884,729...65,897,593

G

unc-119 lipid binding chaperone B

increases expression

clothianidin results in increased expression of UNC119B mRNA

NCBI chr12:41,478,808...41,491,432
Ensembl chr12:41,478,808...41,491,432

G

ubiquitin specific peptidase 43

decreases expression

clothianidin results in decreased expression of USP43 mRNA

NCBI chr10:52,549,200...52,611,168
Ensembl chr10:52,548,963...52,611,533

G

utrophin

decreases expression

clothianidin results in decreased expression of UTRN mRNA

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

G

vesicle-associated membrane protein 8

increases expression

clothianidin results in increased expression of VAMP8 mRNA

NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897

G

vascular endothelial growth factor D

decreases expression

clothianidin results in decreased expression of VEGFD mRNA

NCBI chr X:30,073,122...30,108,413
Ensembl chr X:30,074,163...30,108,295

G

VPS8 subunit of CORVET complex

decreases expression

clothianidin results in decreased expression of VPS8 mRNA

NCBI chr11:79,402,236...79,634,234
Ensembl chr11:79,402,239...79,634,133

G

WASH complex subunit 4

increases expression

clothianidin results in increased expression of WASHC4 mRNA

NCBI chr 7:20,187,905...20,240,228
Ensembl chr 7:20,187,922...20,240,226

G

whirlin

increases expression

clothianidin results in increased expression of WHRN mRNA

NCBI chr 5:76,828,308...76,911,945
Ensembl chr 5:76,828,301...76,912,223

G

Wnt family member 7B

decreases expression

clothianidin results in decreased expression of WNT7B mRNA

NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581

G

yippee-like 2

increases expression

clothianidin results in increased expression of YPEL2 mRNA

NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911

G

yippee-like 3

decreases expression

clothianidin results in decreased expression of YPEL3 mRNA

NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705

G

zinc finger and BTB domain containing 45

decreases expression

clothianidin results in decreased expression of ZBTB45 mRNA

NCBI chr 1:73,634,895...73,639,802
Ensembl chr 1:73,635,448...73,639,556

G

zinc finger CCHC-type containing 13

decreases expression

clothianidin results in decreased expression of ZCCHC13 mRNA

NCBI chr X:68,643,568...68,644,671
Ensembl chr X:68,643,549...68,665,131

G

zinc finger protein 18

decreases expression

clothianidin results in decreased expression of ZNF18 mRNA

NCBI chr10:50,473,428...50,495,707
Ensembl chr10:50,473,483...50,495,706

G

zinc finger protein 219

decreases expression

clothianidin results in decreased expression of ZNF219 mRNA

NCBI chr15:24,695,831...24,710,039
Ensembl chr15:24,695,837...24,710,030

G

zinc finger protein 467

increases expression

clothianidin results in increased expression of ZNF467 mRNA

NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229

G

zinc finger protein 470

increases expression

clothianidin results in increased expression of ZNF470 mRNA

NCBI chr 1:91,063,905...91,111,883
Ensembl chr 1:91,087,361...91,112,065

G

zinc finger protein 502

increases expression

clothianidin results in increased expression of ZNF502 mRNA

NCBI chr 1:28,884,390...28,908,726

G

zinc finger protein 521

decreases expression

clothianidin results in decreased expression of ZNF521 mRNA

NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458

G

zinc finger protein 653

decreases expression

clothianidin results in decreased expression of ZNF653 mRNA

NCBI chr 8:20,586,607...20,605,439
Ensembl chr 8:20,586,563...20,604,864

G

zinc finger protein 865

increases expression

clothianidin results in increased expression of ZNF784 mRNA

NCBI chr 1:68,805,302...68,809,780
Ensembl chr 1:68,805,302...68,809,780

G

zinc finger with KRAB and SCAN domains 7

increases expression

clothianidin results in increased expression of ZKSCAN7 mRNA

NCBI chr 8:122,501,938...122,519,600
Ensembl chr 8:122,502,218...122,519,600

G

zinc finger, SWIM-type containing 4

decreases expression

clothianidin results in decreased expression of ZSWIM4 mRNA

NCBI chr19:23,927,845...23,952,970
Ensembl chr19:23,927,845...23,952,970

cyflufenamid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Sulfur co-treated with zoxamide co-treated with cyflufenamid] results in decreased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

dabigatran

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

allograft inflammatory factor 1

decreases expression

Dabigatran results in decreased expression of AIF1 protein

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

aldehyde dehydrogenase 1 family, member A2

decreases expression

Dabigatran results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

Dabigatran results in decreased expression of EYA1 mRNA

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

G

coagulation factor II, thrombin

decreases activity

Dabigatran results in decreased activity of F2 protein

PMID:17911567 PMID:25138021

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibrinogen alpha chain

multiple interactions

Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

multiple interactions

Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibroblast growth factor 8

increases expression

Dabigatran results in increased expression of FGF8 mRNA

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

fibrinogen gamma chain

multiple interactions

Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]]

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

forkhead box C2

decreases expression

Dabigatran results in decreased expression of FOXC2 mRNA

NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737

G

glial cell derived neurotrophic factor

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

decreases expression

Dabigatran results in decreased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

homeo box B9

increases expression

Dabigatran results in increased expression of HOXB9 mRNA

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

G

mesenchyme homeobox 1

decreases expression

Dabigatran results in decreased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

MER proto-oncogene, tyrosine kinase

increases expression

Dabigatran results in increased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

neurogenin 2

increases expression

Dabigatran results in increased expression of NEUROG2 mRNA

NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA]

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

oligodendrocyte transcription factor 3

increases expression

Dabigatran results in increased expression of OLIG3 mRNA

NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149

G

paired box 3

decreases expression

Dabigatran results in decreased expression of PAX3 mRNA

NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042

G

paired box 6

increases expression

Dabigatran results in increased expression of PAX6 mRNA

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

proteolipid protein 1

increases expression

Dabigatran results in increased expression of PLP1 mRNA

NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032

G

REST corepressor 2

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA]

NCBI chr 1:204,453,403...204,461,403
Ensembl chr 1:204,454,360...204,460,838

G

ret proto-oncogene

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein]

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

solute carrier family 18 member A2

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

synuclein alpha

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

transcription factor 15

decreases expression

Dabigatran results in decreased expression of TCF15 mRNA

NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766

G

tyrosine hydroxylase

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions

Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UNC homeobox

decreases expression

Dabigatran results in decreased expression of UNCX mRNA

NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300

debrisoquin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
increases metabolic processing
increases hydroxylation
affects metabolic processing
increases abundance
decreases metabolic processing
decreases response to substance

CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]
CYP2D6 protein results in increased metabolism of Debrisoquin
CYP2D6 protein results in increased hydroxylation of Debrisoquin
CYP2D6 protein affects the metabolism of Debrisoquin; CYP2D6 protein polymorphism affects the metabolism of Debrisoquin
CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin

PMID:3577206 PMID:6603386 PMID:8946814 PMID:11673748 PMID:11823760 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

diminazene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

increases activity

Diminazene results in increased activity of ACE2 protein

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acid sensing ion channel subunit family member 5

decreases activity

Diminazene results in decreased activity of ASIC5 protein

NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812

dinotefuran

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

dinotefuran results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; dinotefuran results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

PMID:16981889 PMID:25459289

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

formetanate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

formetanate results in decreased activity of ACHE protein

PMID:19934164 PMID:21251949

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

butyrylcholinesterase

multiple interactions

[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

heat shock protein family A (Hsp70) member 1A

decreases expression

formetanate results in decreased expression of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

increases expression

formetanate results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

decreases expression

formetanate results in decreased expression of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

NFE2 like bZIP transcription factor 2

increases activity

formetanate results in increased activity of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

Parkinsonism associated deglycase

decreases activity

formetanate results in decreased activity of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

guanethidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Guanethidine results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

acid phosphatase 5, tartrate resistant

affects expression
increases expression

Guanethidine affects the expression of ACP5 protein
Guanethidine results in increased expression of ACP5 mRNA

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

cathepsin K

increases expression
affects expression

Guanethidine results in increased expression of CTSK mRNA
Guanethidine affects the expression of CTSK protein

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Guanethidine inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

matrix metallopeptidase 13

increases expression

Guanethidine results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

neuropeptide Y

decreases expression
decreases secretion

Guanethidine results in decreased expression of NPY protein
Guanethidine results in decreased secretion of NPY protein

PMID:9460767 PMID:14527964 PMID:15003356

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

serpin family E member 1

multiple interactions

Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

tyrosine hydroxylase

decreases expression

Guanethidine results in decreased expression of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

vasoactive intestinal peptide

decreases expression

Guanethidine results in decreased expression of VIP protein

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

guanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions
affects folding
decreases folding

Guanidine affects the folding of [acrylodan binds to ALB protein]; Guanidine inhibits the reaction [prodan binds to ALB protein]
Guanidine affects the folding of ALB protein
Guanidine results in decreased folding of ALB protein

PMID:12044178 PMID:15353599

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

solute carrier family 22 member 16

multiple interactions

Guanidine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]

NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019

G

solute carrier family 22 member 3

increases uptake
multiple interactions

SLC22A3 protein results in increased uptake of Guanidine
Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]

PMID:9830022 PMID:10966924

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 47 member 1

multiple interactions

Guanidine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Guanidine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases folding

Guanidine results in decreased folding of SOD1 protein mutant form

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

melagatran

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coagulation factor II, thrombin

multiple interactions

melagatran binds to and results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

N'-(2,4-dimethylphenyl)-N-methylformamidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases expression
multiple interactions

U 40481 results in decreased expression of CAT protein
KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

U 40481 results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

U 40481 results in increased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

U 40481 results in increased expression of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

U 40481 results in increased expression of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

U 40481 results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

U 40481 results in increased expression of CYP3A23-3A1 protein

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

glucagon

increases secretion

U 40481 results in increased secretion of GCG protein

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

Kelch-like ECH-associated protein 1

increases expression
multiple interactions

U 40481 results in increased expression of KEAP1 protein
KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [U 40481 results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [U 40481 results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [U 40481 results in decreased expression of SOD1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

KEAP1 protein affects the reaction [U 40481 results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

decreases expression
multiple interactions

U 40481 results in decreased expression of NQO1 protein
KEAP1 protein affects the reaction [U 40481 results in decreased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

superoxide dismutase 1

multiple interactions
decreases expression

KEAP1 protein affects the reaction [U 40481 results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

N-[3-(aminomethyl)benzyl]acetamidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 2

affects response to substance

AKT2 protein affects the susceptibility to N-(3-(aminomethyl)benzyl)acetamidine

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

BCL2 interacting protein 3

multiple interactions

[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

caveolin 1

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxygen deficiency results in increased expression of CAV1 protein]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

heme oxygenase 1

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interferon gamma

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

insulin 1

increases response to substance

N-(3-(aminomethyl)benzyl)acetamidine results in increased susceptibility to INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

integrin subunit beta 2

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

leptin receptor

increases response to substance

LEPR gene mutant form results in increased susceptibility to N-(3-(aminomethyl)benzyl)acetamidine

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

myeloperoxidase

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:11504810 PMID:11713966

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions
decreases activity

[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] which results in increased susceptibility to endothelium-dependent hyperpolarization factor; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]

PMID:11076874 PMID:11134894 PMID:16461118 PMID:16933320 PMID:19442826 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

RAP1A, member of RAS oncogene family

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RAP2A, member of RAS oncogene family

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein]

NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138

G

transferrin receptor

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [GGTI 298 results in decreased expression of TFRC protein]

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

tumor necrosis factor

multiple interactions

N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

N-methyl-N'-nitro-N-nitrosoguanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acyl-CoA oxidase 2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

ADAM metallopeptidase domain 10

increases expression

Methylnitronitrosoguanidine results in increased expression of ADAM10 mRNA

NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889

G

angiotensinogen

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
increases localization

benzamide inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]; phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

decreases secretion

Methylnitronitrosoguanidine results in decreased secretion of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

alkaline phosphatase, biomineralization associated

increases expression

Methylnitronitrosoguanidine results in increased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

alpha-1-microglobulin/bikunin precursor

decreases expression

Methylnitronitrosoguanidine results in decreased expression of AMBP mRNA

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

annexin A5

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apoptotic peptidase activating factor 1

affects response to substance
decreases expression
multiple interactions

APAF1 protein affects the susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in decreased expression of APAF1 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]

PMID:16019050 PMID:20434464

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

increases expression

Methylnitronitrosoguanidine results in increased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

amyloid beta precursor protein

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

A-Raf proto-oncogene, serine/threonine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

ATM serine/threonine kinase

increases response to substance

ATM gene mutant form results in increased susceptibility to Methylnitronitrosoguanidine

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit beta 3

decreases expression

Methylnitronitrosoguanidine results in decreased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598

G

ATR serine/threonine kinase

multiple interactions

ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

Axl receptor tyrosine kinase

increases expression

Methylnitronitrosoguanidine results in increased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

BCL2-associated agonist of cell death

decreases expression
decreases phosphorylation
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of BAD mRNA
Methylnitronitrosoguanidine results in decreased phosphorylation of BAD protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of BAD protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA]

PMID:17828454 PMID:20434464

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

increases expression

Methylnitronitrosoguanidine results in increased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BCL2-antagonist/killer 1

multiple interactions

BAK1 protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression

[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Methylnitronitrosoguanidine results in decreased expression of BAX mRNA; Methylnitronitrosoguanidine results in decreased expression of BAX protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
BAX protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]

PMID:16030430 PMID:18376143 PMID:20434464 PMID:35103375

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 2

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BCAT2 mRNA

NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

Methylnitronitrosoguanidine results in decreased expression of BCL2 protein
Methylnitronitrosoguanidine results in increased expression of BCL2 protein
weifuchun affects the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA; Methylnitronitrosoguanidine results in increased expression of BCL2 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]

PMID:16019050 PMID:16030430 PMID:20434464 PMID:35103375 PMID:36403744

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
increases expression

BCL2L1 protein results in decreased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]
Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA]

PMID:18376143 PMID:20434464

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

multiple interactions

[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein]

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

brain-derived neurotrophic factor

increases expression

Methylnitronitrosoguanidine results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

biglycan

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

BH3 interacting domain death agonist

multiple interactions
decreases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 2

increases expression

Methylnitronitrosoguanidine results in increased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

biliverdin reductase B

multiple interactions

[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

bone morphogenetic protein 4

decreases expression

Methylnitronitrosoguanidine results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BRCA1, DNA repair associated

increases expression

Methylnitronitrosoguanidine results in increased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

increases expression

Methylnitronitrosoguanidine results in increased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

basigin

multiple interactions
increases expression

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA]

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

BTG anti-proliferation factor 2

decreases expression

Methylnitronitrosoguanidine results in decreased expression of BTG2 protein

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C1q B chain

increases expression

Methylnitronitrosoguanidine results in increased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

complement C1s

increases expression

Methylnitronitrosoguanidine results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

calmodulin 1

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

caspase 3

increases activity
decreases expression
multiple interactions

Methylnitronitrosoguanidine results in increased activity of CASP3 protein
Methylnitronitrosoguanidine results in decreased expression of CASP3 protein
Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA; Methylnitronitrosoguanidine results in decreased expression of CASP3 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Methylnitronitrosoguanidine results in increased activity of CASP3 protein]
[Methylnitronitrosoguanidine co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in increased activity of CASP3 protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]

PMID:15589979 PMID:16019050 PMID:16030430 PMID:17428624 PMID:20434464 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

Methylnitronitrosoguanidine results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

multiple interactions

[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
decreases expression
multiple interactions

Methylnitronitrosoguanidine results in increased activity of CASP9 protein
Methylnitronitrosoguanidine results in decreased expression of CASP9 protein
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]

PMID:15589979 PMID:16019050 PMID:20434464 PMID:35103375

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 5

decreases expression

Methylnitronitrosoguanidine results in decreased expression of CBX5 mRNA

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

cyclin A1

increases expression

Methylnitronitrosoguanidine results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1

multiple interactions
decreases expression
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA]
Methylnitronitrosoguanidine results in decreased expression of CCNB1 mRNA
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNA

PMID:11516527 PMID:12135628 PMID:19851710

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
increases expression

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCND1 protein
Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA; Methylnitronitrosoguanidine results in increased expression of CCND1 protein

PMID:12135628 PMID:19851710 PMID:21628965

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G1

increases expression

Methylnitronitrosoguanidine results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin H

increases expression

Methylnitronitrosoguanidine results in increased expression of CCNH mRNA

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

G

chaperonin containing TCP1 subunit 2

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

CD14 molecule

increases expression
multiple interactions

Methylnitronitrosoguanidine results in increased expression of CD14 protein
weifuchun inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CD14 protein]

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD59b molecule

increases mutagenesis

Methylnitronitrosoguanidine results in increased mutagenesis of CD59 protein

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

CD9 molecule

multiple interactions

[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD9 mRNA

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222