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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein] |
CTD |
PMID:29355567 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCG1 protein] |
CTD |
PMID:29355567 |
|
NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:18031796 PMID:33034787 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA] |
CTD |
PMID:18031796 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] |
CTD |
PMID:17472962 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] |
CTD |
PMID:18310456 |
|
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] |
CTD |
PMID:15200425 PMID:16470222 PMID:18766339 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]] |
CTD |
PMID:15298857 |
|
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein] |
CTD |
PMID:26577051 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] |
CTD |
PMID:26577051 |
|
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] |
CTD |
PMID:17507688 |
|
NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein] |
CTD |
PMID:26577051 |
|
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein] |
CTD |
PMID:26577051 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein] |
CTD |
PMID:18625202 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] |
CTD |
PMID:16575855 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] |
CTD |
PMID:18023360 |
|
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] |
CTD |
PMID:21918126 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [resveratrol results in increased expression of CYP7A1 mRNA] |
CTD |
PMID:22607622 |
|
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA] |
CTD |
PMID:18031796 |
|
NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
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G |
Fbxo32 |
F-box protein 32 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein] |
CTD |
PMID:19406843 |
|
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436
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G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein] |
CTD |
PMID:33034787 |
|
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
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G |
Ggps1 |
geranylgeranyl diphosphate synthase 1 |
decreases activity |
ISO |
geranylgeranyl pyrophosphate analog results in decreased activity of GGPS1 protein |
CTD |
PMID:16787319 |
|
NCBI chr17:55,958,750...55,982,762
Ensembl chr17:51,263,263...51,276,220
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate |
CTD |
PMID:17208200 |
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NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]] |
CTD |
PMID:18625914 |
|
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] |
CTD |
PMID:10946302 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] |
CTD |
PMID:17507688 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] |
CTD |
PMID:15187114 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]] |
CTD |
PMID:15705589 PMID:15728660 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 PMID:17075836 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]] |
CTD |
PMID:16511915 PMID:17075836 PMID:17729120 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf4 |
interferon regulatory factor 4 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein] |
CTD |
PMID:33034787 |
|
NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070
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G |
Lep |
leptin |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] |
CTD |
PMID:19254925 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]] |
CTD |
PMID:16470222 PMID:18625914 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:16470222 PMID:18625914 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mbp |
myelin basic protein |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA] |
CTD |
PMID:20578043 |
|
NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] |
CTD |
PMID:17303772 PMID:18625914 |
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NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]] |
CTD |
PMID:15728660 PMID:19299917 |
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NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G |
Mstn |
myostatin |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN protein] |
CTD |
PMID:33034787 |
|
NCBI chr 9:55,944,513...55,950,913
Ensembl chr 9:48,452,533...48,458,933
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G |
Mvk |
mevalonate kinase |
multiple interactions decreases chemical synthesis decreases activity |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] MVK protein mutant form results in decreased chemical synthesis of geranylgeranyl pyrophosphate geranylgeranyl pyrophosphate results in decreased activity of MVK protein |
CTD |
PMID:9392419 PMID:24073415 |
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NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] |
CTD |
PMID:17075836 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]] |
CTD |
PMID:15705589 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
decreases activity |
ISO |
geranylgeranyl pyrophosphate results in decreased activity of NR1H3 protein |
CTD |
PMID:22607622 |
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NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722
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G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] |
CTD |
PMID:16005304 |
|
NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] |
CTD |
PMID:21910007 |
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] |
CTD |
PMID:15728660 |
|
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein] |
CTD |
PMID:10412747 |
|
NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223
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G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] |
CTD |
PMID:14500290 |
|
NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA] |
CTD |
PMID:20578043 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA] |
CTD |
PMID:20578043 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] |
CTD |
PMID:17279352 PMID:18625914 |
|
NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251
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G |
Retn |
resistin |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] |
CTD |
PMID:18023360 |
|
NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]] |
CTD |
PMID:16005304 PMID:16470222 PMID:17075836 PMID:18031796 PMID:18310456 PMID:18625202 PMID:18625914 More...
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NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
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G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] |
CTD |
PMID:18310456 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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G |
Sele |
selectin E |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 |
|
NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741
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G |
Sox10 |
SRY-box transcription factor 10 |
multiple interactions |
EXP |
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA] |
CTD |
PMID:20578043 |
|
NCBI chr 7:112,605,721...112,615,097
Ensembl chr 7:110,725,274...110,735,544
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions increases expression |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein] geranylgeranyl pyrophosphate results in increased expression of STAT1 protein |
CTD |
PMID:17507688 |
|
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]] |
CTD |
PMID:15298857 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]] |
CTD |
PMID:16511915 PMID:17075836 PMID:17729120 PMID:18310456 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] |
CTD |
PMID:21910007 |
|
NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] |
CTD |
PMID:18356691 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:33034787 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] |
CTD |
PMID:17472962 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] |
CTD |
PMID:18310456 |
|
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein] farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] |
CTD |
PMID:15200425 PMID:18766339 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] |
CTD |
PMID:21918126 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
|
|
G |
Fnta |
farnesyltransferase, CAAX box, subunit alpha |
multiple interactions |
EXP |
[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] |
CTD |
PMID:10673434 |
|
NCBI chr16:72,767,864...72,786,193
Ensembl chr16:66,065,132...66,083,460
|
|
G |
Fntb |
farnesyltransferase, CAAX box, subunit beta |
multiple interactions |
EXP |
[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] |
CTD |
PMID:10673434 |
|
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA] |
CTD |
PMID:16005304 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein] |
CTD |
PMID:33034787 |
|
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate |
CTD |
PMID:17208200 |
|
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]] |
CTD |
PMID:18625914 |
|
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] |
CTD |
PMID:10946302 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] |
CTD |
PMID:15187114 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
EXP |
[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] |
CTD |
PMID:10673434 |
|
NCBI chr 4:179,916,255...179,949,613
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]] |
CTD |
PMID:19299917 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mvk |
mevalonate kinase |
decreases activity decreases chemical synthesis multiple interactions |
ISO |
farnesyl pyrophosphate results in decreased activity of MVK protein MVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphate farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] |
CTD |
PMID:9392419 PMID:24073415 |
|
NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882
|
|
G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] |
CTD |
PMID:14500290 PMID:15690306 |
|
NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
|
|
G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] |
CTD |
PMID:18625914 |
|
NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251
|
|
G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]] farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]] |
CTD |
PMID:18310456 PMID:18625914 |
|
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] |
CTD |
PMID:18310456 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
|
|
G |
Sele |
selectin E |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 |
|
NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:33034787 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] |
CTD |
PMID:17472962 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] |
CTD |
PMID:18310456 |
|
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein] farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] |
CTD |
PMID:15200425 PMID:18766339 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] |
CTD |
PMID:21918126 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
|
|
G |
Fnta |
farnesyltransferase, CAAX box, subunit alpha |
multiple interactions |
EXP |
[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] |
CTD |
PMID:10673434 |
|
NCBI chr16:72,767,864...72,786,193
Ensembl chr16:66,065,132...66,083,460
|
|
G |
Fntb |
farnesyltransferase, CAAX box, subunit beta |
multiple interactions |
EXP |
[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] |
CTD |
PMID:10673434 |
|
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA] |
CTD |
PMID:16005304 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein] |
CTD |
PMID:33034787 |
|
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate |
CTD |
PMID:17208200 |
|
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]] |
CTD |
PMID:18625914 |
|
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] |
CTD |
PMID:10946302 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] |
CTD |
PMID:15187114 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
EXP |
[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] |
CTD |
PMID:10673434 |
|
NCBI chr 4:179,916,255...179,949,613
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]] |
CTD |
PMID:19299917 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mvk |
mevalonate kinase |
decreases activity multiple interactions decreases chemical synthesis |
ISO |
farnesyl pyrophosphate results in decreased activity of MVK protein farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] MVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphate |
CTD |
PMID:9392419 PMID:24073415 |
|
NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882
|
|
G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] |
CTD |
PMID:14500290 PMID:15690306 |
|
NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
|
|
G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] |
CTD |
PMID:18625914 |
|
NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251
|
|
G |
Rhoa |
ras homolog family member A |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]] farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]] |
CTD |
PMID:18310456 PMID:18625914 |
|
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] |
CTD |
PMID:18310456 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
|
|
G |
Sele |
selectin E |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
CTD |
PMID:10946302 |
|
NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] |
CTD |
PMID:18310456 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases abundance |
ISO |
[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate] |
CTD |
PMID:19819230 PMID:19856009 |
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NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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G |
Mvk |
mevalonate kinase |
decreases activity multiple interactions |
ISO |
geranyl diphosphate results in decreased activity of MVK protein geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] |
CTD |
PMID:9392419 |
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NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882
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G |
Rap1a |
RAP1A, member of RAS oncogene family |
multiple interactions |
ISO |
[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form |
CTD |
PMID:19819230 |
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NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
decreases expression |
ISO |
isopentenyl pyrophosphate results in decreased expression of CCR5 protein |
CTD |
PMID:11994442 |
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NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
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G |
Fdps |
farnesyl diphosphate synthase |
multiple interactions |
ISO |
[zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphate |
CTD |
PMID:19699819 |
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NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776
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G |
Fgf9 |
fibroblast growth factor 9 |
increases expression |
ISO |
isopentenyl pyrophosphate results in increased expression of FGF9 mRNA; isopentenyl pyrophosphate results in increased expression of FGF9 protein |
CTD |
PMID:14704367 |
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NCBI chr15:36,325,552...36,369,995
Ensembl chr15:32,210,074...32,253,309
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
ISO |
Calcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IFNG protein] |
CTD |
PMID:15879110 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
multiple interactions increases expression |
ISO |
Calcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IL2RA protein] |
CTD |
PMID:15879110 |
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NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
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G |
Mvk |
mevalonate kinase |
multiple interactions decreases activity |
ISO |
isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] isopentenyl pyrophosphate results in decreased activity of MVK protein |
CTD |
PMID:9392419 |
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NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
multiple interactions |
ISO |
isopentenyl pyrophosphate inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] |
CTD |
PMID:21353389 |
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NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570
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G |
Trpv3 |
transient receptor potential cation channel, subfamily V, member 3 |
multiple interactions |
ISO |
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein] |
CTD |
PMID:21353389 |
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NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296
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G |
Vdr |
vitamin D receptor |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]; Go 6976 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]; U 0126 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein] |
CTD |
PMID:15879110 |
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NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
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G |
Il12rb1 |
interleukin 12 receptor subunit beta 1 |
increases expression |
ISO |
3,3-dimethylallyl pyrophosphate results in increased expression of IL12RB1 protein |
CTD |
PMID:12932289 |
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NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,620,770...18,632,769
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G |
Mvk |
mevalonate kinase |
decreases activity multiple interactions |
ISO |
3,3-dimethylallyl pyrophosphate results in decreased activity of MVK protein 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] |
CTD |
PMID:9392419 |
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NCBI chr12:47,802,002...47,819,503
Ensembl chr12:42,141,384...42,158,882
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
increases expression |
ISO |
3,3-dimethylallyl pyrophosphate results in increased expression of TNFRSF1B protein |
CTD |
PMID:12932289 |
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NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
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