polyprenol - Ontology Report - Rat Genome Database

geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein]

PMID:29355567

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

Abcg1

ATP binding cassette subfamily G member 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCG1 protein]

PMID:29355567

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

Akt1

AKT serine/threonine kinase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]

PMID:18031796 PMID:33034787

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Bcl2

BCL2, apoptosis regulator

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA]

PMID:18031796

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

baculoviral IAP repeat-containing 5

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]

PMID:17472962

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Bmp2

bone morphogenetic protein 2

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

caspase 3

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]

PMID:15200425 PMID:16470222 PMID:18766339

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Ccn2

cellular communication network factor 2

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]

PMID:15298857

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

Ccna2

cyclin A2

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

Ccne1

cyclin E1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

Cd40

CD40 molecule

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]

PMID:17507688

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

Cdk1

cyclin-dependent kinase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

Cdk2

cyclin dependent kinase 2

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein]

PMID:18625202

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Col1a1

collagen type I alpha 1 chain

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]

PMID:16575855

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Crp

C-reactive protein

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]

PMID:18023360

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

Cyp17a1

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]

PMID:21918126

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

Cyp7a1

cytochrome P450 family 7 subfamily A member 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [resveratrol results in increased expression of CYP7A1 mRNA]

PMID:22607622

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

coagulation factor III, tissue factor

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]

PMID:18031796

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Fbxo32

F-box protein 32

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]

PMID:19406843

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

Foxo1

forkhead box O1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

Ggps1

geranylgeranyl diphosphate synthase 1

decreases activity

geranylgeranyl pyrophosphate analog results in decreased activity of GGPS1 protein

PMID:16787319

NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate

PMID:17208200

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

HRas proto-oncogene, GTPase

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

intercellular adhesion molecule 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Ifng

interferon gamma

multiple interactions

PMID:17507688

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Il12b

interleukin 12B

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein]

PMID:15187114

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

Il1a

interleukin 1 alpha

multiple interactions

PMID:15705589 PMID:15728660

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

interleukin 1 beta

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]

PMID:10946302 PMID:17075836

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il6

interleukin 6

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]

PMID:16511915 PMID:17075836 PMID:17729120

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Irf4

interferon regulatory factor 4

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

Lep

leptin

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein]

PMID:19254925

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

mitogen activated protein kinase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]

PMID:16470222 PMID:18625914

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]

PMID:16470222 PMID:18625914

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mbp

myelin basic protein

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

Mmp1

matrix metallopeptidase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein]

PMID:17303772 PMID:18625914

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

matrix metallopeptidase 9

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]

PMID:15728660 PMID:19299917

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mstn

myostatin

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN protein]

NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933

mevalonate kinase

multiple interactions
decreases chemical synthesis
decreases activity

geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
MVK protein mutant form results in decreased chemical synthesis of geranylgeranyl pyrophosphate
geranylgeranyl pyrophosphate results in decreased activity of MVK protein

PMID:9392419 PMID:24073415

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Nfkbia

NFKB inhibitor alpha

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]

PMID:17075836

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Nos2

nitric oxide synthase 2

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]

PMID:15705589

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Nr1h3

nuclear receptor subfamily 1, group H, member 3

decreases activity

geranylgeranyl pyrophosphate results in decreased activity of NR1H3 protein

PMID:22607622

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

Nr4a3

nuclear receptor subfamily 4, group A, member 3

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA]

PMID:16005304

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

Parp1

poly (ADP-ribose) polymerase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]]

PMID:21910007

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Pdgfb

platelet derived growth factor subunit B

multiple interactions

PMID:15728660

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

Plat

plasminogen activator, tissue type

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]

PMID:10412747

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

Pon1

paraoxonase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]

PMID:14500290

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

Pparg

peroxisome proliferator-activated receptor gamma

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Pten

phosphatase and tensin homolog

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

Rac family small GTPase 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]

PMID:17279352 PMID:18625914

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

Retn

resistin

multiple interactions

PMID:18023360

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

ras homolog family member A

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]

PMID:16005304 PMID:16470222 PMID:17075836 PMID:18031796 PMID:18310456 More...

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Runx2

RUNX family transcription factor 2

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

selectin E

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

Sox10

SRY-box transcription factor 10

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]

NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544

Stat1

signal transducer and activator of transcription 1

multiple interactions
increases expression

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]
geranylgeranyl pyrophosphate results in increased expression of STAT1 protein

PMID:17507688

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

Tgfb1

transforming growth factor, beta 1

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]

PMID:15298857

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

tumor necrosis factor

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]

PMID:16511915 PMID:17075836 PMID:17729120 PMID:18310456

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfsf10

TNF superfamily member 10

multiple interactions

PMID:21910007

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

Vegfa

vascular endothelial growth factor A

multiple interactions

geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]

PMID:18356691

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

2-trans,6-trans-farnesyl diphosphate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akt1

AKT serine/threonine kinase 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

baculoviral IAP repeat-containing 5

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]

PMID:17472962

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Bmp2

bone morphogenetic protein 2

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

caspase 3

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]

PMID:15200425 PMID:18766339

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cyp17a1

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]

PMID:21918126

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

Fnta

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein]

NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460

Fntb

farnesyltransferase, CAAX box, subunit beta

multiple interactions

[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein]

NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA]

PMID:16005304

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Foxo1

forkhead box O1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate

PMID:17208200

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

HRas proto-oncogene, GTPase

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

intercellular adhesion molecule 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Il12b

interleukin 12B

multiple interactions

farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein]

PMID:15187114

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

interleukin 1 beta

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Kras

KRAS proto-oncogene, GTPase

multiple interactions

[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein]

NCBI chr 4:178,185,418...178,218,484

mitogen activated protein kinase 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

matrix metallopeptidase 9

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]

PMID:19299917

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

mevalonate kinase

decreases activity
decreases chemical synthesis
multiple interactions

farnesyl pyrophosphate results in decreased activity of MVK protein
MVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphate
farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]

PMID:9392419 PMID:24073415

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Pon1

paraoxonase 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA]

PMID:14500290 PMID:15690306

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

Rac family small GTPase 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

ras homolog family member A

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]

PMID:18310456 PMID:18625914

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Runx2

RUNX family transcription factor 2

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

selectin E

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

tumor necrosis factor

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

dolichyl phosphate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

mevalonate kinase

decreases activity
multiple interactions

dolichol monophosphate results in decreased activity of MVK protein
dolichol monophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; dolichol monophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]

PMID:9392419

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

farnesol

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Acaa1a

acetyl-CoA acyltransferase 1A

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

Acaa2

acetyl-CoA acyltransferase 2

multiple interactions
increases expression

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA
Farnesol analog results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

Acadm

acyl-CoA dehydrogenase medium chain

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

Acads

acyl-CoA dehydrogenase short chain

multiple interactions
increases expression

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADS mRNA
Farnesol analog results in increased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

Acat1

acetyl-CoA acetyltransferase 1

increases expression

Farnesol analog results in increased expression of ACAT1 mRNA

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

Acat2

acetyl-CoA acetyltransferase 2

increases expression

Farnesol analog results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

Acot1

acyl-CoA thioesterase 1

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

Acot12

acyl-CoA thioesterase 12

increases expression
multiple interactions

Farnesol analog results in increased expression of ACOT12 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA

NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536

Acot6

acyl-CoA thioesterase 6

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of ACOT6 mRNA

NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446

Acox1

acyl-CoA oxidase 1

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

Acox2

acyl-CoA oxidase 2

decreases expression
increases expression

Farnesol analog results in decreased expression of ACOX2 mRNA
Farnesol analog results in increased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

Acsl4

acyl-CoA synthetase long-chain family member 4

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

Acsl5

acyl-CoA synthetase long-chain family member 5

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

Agpat1

1-acylglycerol-3-phosphate O-acyltransferase 1

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of AGPAT1 mRNA

NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278

Akr1b10

aldo-keto reductase family 1 member B10

increases chemical synthesis

AKR1B10 protein results in increased chemical synthesis of Farnesol

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

Akr1c1

aldo-keto reductase family 1, member C1

increases expression

Farnesol results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

Akr1c3

aldo-keto reductase family 1, member C3

increases chemical synthesis
multiple interactions

AKR1C3 protein results in increased chemical synthesis of Farnesol
[Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

Apoa5

apolipoprotein A5

multiple interactions
increases expression

[Farnesol analog co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
Farnesol analog results in increased expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

Apoc4

apolipoprotein C4

decreases expression

Farnesol analog results in decreased expression of APOC4 mRNA

NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981

Atf3

activating transcription factor 3

increases expression

Farnesol results in increased expression of ATF3 mRNA

PMID:27965148

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

Bak1

BCL2-antagonist/killer 1

increases expression

Farnesol results in increased expression of BAK1 protein

PMID:12530055

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

caspase 3

increases activity
decreases activity

Farnesol results in increased activity of CASP3 protein
Farnesol results in decreased activity of CASP3 protein

PMID:10733934 PMID:21453689

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cat

catalase

increases expression
multiple interactions

Farnesol results in increased expression of CAT protein
Farnesol inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]
Farnesol inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]

PMID:18793622 PMID:21453689 PMID:37458150

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Ccl4

C-C motif chemokine ligand 4

increases secretion

Farnesol results in increased secretion of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

Ccna2

cyclin A2

decreases expression

Farnesol results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

Ccnb1

cyclin B1

decreases expression

Farnesol results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

Cdk2

cyclin dependent kinase 2

decreases expression
multiple interactions

Farnesol results in decreased expression of CDK2 protein
Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
increases response to substance

Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
Farnesol results in increased expression of CDKN1A protein
CDKN1A protein results in increased susceptibility to Farnesol

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn1b

cyclin-dependent kinase inhibitor 1B

increases response to substance
increases expression
multiple interactions

CDKN1B protein results in increased susceptibility to Farnesol
Farnesol results in increased expression of CDKN1B protein
Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

Cox10

cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

decreases expression

Farnesol analog results in decreased expression of COX10 mRNA

NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667

Cpt1a

carnitine palmitoyltransferase 1A

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

Cyp19a1

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity

Farnesol results in increased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
increases expression

Farnesol results in increased activity of CYP1A1 protein
Farnesol results in increased expression of CYP1A1 mRNA

PMID:15840382 PMID:30806763

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
multiple interactions

Farnesol results in increased activity of CYP1A2 protein
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP1A2 mRNA]

PMID:15840382 PMID:30611723

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

Cyp2a1

cytochrome P450, family 2, subfamily a, polypeptide 1

increases activity

Farnesol results in increased activity of CYP2A1 protein

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

Cyp2a2

cytochrome P450, family 2, subfamily a, polypeptide 2

increases activity

Farnesol results in increased activity of CYP2A2 protein

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

Cyp2a3

cytochrome P450, family 2, subfamily a, polypeptide 3

increases activity

Farnesol results in increased activity of CYP2A3 protein

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

Cyp2b1

cytochrome P450, family 2, subfamily b, polypeptide 1

increases activity

Farnesol results in increased activity of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

Cyp2b2

cytochrome P450, family 2, subfamily b, polypeptide 2

increases activity

Farnesol results in increased activity of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

Cyp2b3

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression

[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2B6 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP2B6 mRNA]
Farnesol analog results in increased expression of CYP2B6 mRNA; Farnesol results in increased expression of CYP2B6 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

Cyp2c11

cytochrome P450, subfamily 2, polypeptide 11

increases activity

Farnesol results in increased activity of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

Cyp2c12

cytochrome P450, family 2, subfamily c, polypeptide 12

increases activity

Farnesol results in increased activity of CYP2C12 protein

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

increases activity
multiple interactions
decreases expression

Farnesol results in increased activity of CYP2E1 protein
[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]
Farnesol analog results in decreased expression of CYP2E1 mRNA; Farnesol results in decreased expression of CYP2E1 mRNA

PMID:15840382 PMID:30611723

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

increases activity
increases expression
multiple interactions

Farnesol results in increased activity of CYP3A2 protein
Farnesol results in increased expression of CYP3A4 mRNA
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP3A4 mRNA]

PMID:15840382 PMID:30611723

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

Cyp3a23-3a1

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases activity

Farnesol results in increased activity of CYP3A23-3A1 protein

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

Cyp4a1

cytochrome P450, family 4, subfamily a, polypeptide 1

increases activity

Farnesol results in increased activity of CYP4A1 protein

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

Cyp4a2

cytochrome P450, family 4, subfamily a, polypeptide 2

increases activity

Farnesol results in increased activity of CYP4A2 protein

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165

Cyp4a3

cytochrome P450, family 4, subfamily a, polypeptide 3

increases activity

Farnesol results in increased activity of CYP4A3 protein

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

Decr1

2,4-dienoyl-CoA reductase 1

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

Dgat1

diacylglycerol O-acyltransferase 1

decreases expression

Farnesol analog results in decreased expression of DGAT1 mRNA

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

Dgat2

diacylglycerol O-acyltransferase 2

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

Dnajb4

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Farnesol results in increased expression of DNAJB4 mRNA

PMID:27965148

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

Ech1

enoyl-CoA hydratase 1

increases expression

Farnesol analog results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

Egf

epidermal growth factor

multiple interactions

Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

Elovl6

ELOVL fatty acid elongase 6

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

Fabp1

fatty acid binding protein 1

increases expression

Farnesol analog results in increased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

Fabp4

fatty acid binding protein 4

increases expression

Farnesol results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

Fasn

fatty acid synthase

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Fdft1

farnesyl diphosphate farnesyl transferase 1

increases expression

Farnesol analog results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

Fnta

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of FNTA mRNA

NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460

Fntb

farnesyltransferase, CAAX box, subunit beta

decreases expression

Farnesol analog results in decreased expression of FNTB mRNA

NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586

Gpat4

glycerol-3-phosphate acyltransferase 4

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of GPAT4 mRNA

NCBI chr16:68,819,031...68,852,903
Ensembl chr16:68,819,079...68,852,901

Gpt

glutamic--pyruvic transaminase

multiple interactions

Farnesol inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

PMID:37458150

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Gsr

glutathione-disulfide reductase

increases activity
multiple interactions
increases expression

Farnesol results in increased activity of GSR protein
Farnesol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]
Farnesol results in increased expression of GSR protein

PMID:15840382 PMID:21453689 PMID:37458150

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Hadha

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression
multiple interactions

Farnesol analog results in increased expression of HADHA mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHA mRNA

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

Hadhb

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression
multiple interactions

Farnesol analog results in increased expression of HADHB mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases expression
decreases activity

[Farnesol analog co-treated with Oleic Acid] results in increased expression of HMGCR mRNA
Farnesol results in increased expression of HMGCR protein
Farnesol results in decreased activity of HMGCR protein

PMID:12477733 PMID:16332721 PMID:30611723

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

Hmox1

heme oxygenase 1

increases expression

Farnesol results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

HRas proto-oncogene, GTPase

multiple interactions

Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]

PMID:12477733

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

intercellular adhesion molecule 1

increases expression

Farnesol results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Ikbkb

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Farnesol inhibits the reaction [Acetaminophen results in increased expression of IKBKB mRNA]

PMID:37458150

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

Il16

interleukin 16

increases secretion

Farnesol results in increased secretion of IL16 protein

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

Il1a

interleukin 1 alpha

increases expression

Farnesol results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

interleukin 1 beta

multiple interactions

Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Farnesol inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]

PMID:20304105 PMID:37458150

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1r2

interleukin 1 receptor type 2

increases expression

Farnesol results in increased expression of IL1R2 mRNA

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

Il6

interleukin 6

multiple interactions

Farnesol inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]

PMID:37458150

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Ins2

insulin 2

multiple interactions

Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

Lipc

lipase C, hepatic type

increases expression

Farnesol analog results in increased expression of LIPC mRNA

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

Lpin1

lipin 1

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

Lpin3

lipin 3

decreases expression

Farnesol analog results in decreased expression of LPIN3 mRNA

NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327

Mlxipl

MLX interacting protein-like

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

Mmp3

matrix metallopeptidase 3

increases expression

Farnesol results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

mevalonate kinase

decreases activity
multiple interactions

Farnesol results in decreased activity of MVK protein
Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; Farnesol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]

PMID:9392419 PMID:20304105

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Myl9

myosin light chain 9

multiple interactions

Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein]

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

Nqo1

NAD(P)H quinone dehydrogenase 1

increases activity

Farnesol results in increased activity of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Nr0b2

nuclear receptor subfamily 0, group B, member 2

decreases expression
multiple interactions

Farnesol analog results in decreased expression of NR0B2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

Nr1h4

nuclear receptor subfamily 1, group H, member 4

multiple interactions
decreases expression

Farnesol binds to and results in increased activity of NR1H4 protein
Farnesol analog results in decreased expression of NR1H4 mRNA

PMID:15491415 PMID:30611723

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

Pck1

phosphoenolpyruvate carboxykinase 1

multiple interactions
decreases expression

[Farnesol analog co-treated with Oleic Acid] results in increased expression of PCK1 mRNA
Farnesol analog results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

Pdss1

decaprenyl diphosphate synthase subunit 1

increases expression

Farnesol analog results in increased expression of PDSS1 mRNA

NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730

Plin2

perilipin 2

increases expression
multiple interactions

Farnesol analog results in increased expression of PLIN2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

Ppara

peroxisome proliferator activated receptor alpha

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARA mRNA; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]

PMID:11779144 PMID:30611723

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

Pparg

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

[Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARG mRNA
Farnesol analog results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Ppargc1a

PPARG coactivator 1 alpha

multiple interactions

Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]

PMID:22343369

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

Rabggta

Rab geranylgeranyltransferase subunit alpha

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTA mRNA

NCBI chr15:29,206,328...29,213,398
Ensembl chr15:29,206,157...29,213,348

Rabggtb

Rab geranylgeranyltransferase subunit beta

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTB mRNA

NCBI chr 2:242,844,758...242,850,951
Ensembl chr 2:242,844,762...242,851,050

Rac family small GTPase 1

multiple interactions

Farnasol inhibits the reaction [Ropivacaine decreases activity of RAC1 protein in esophageal carcinoma cells]

RGD

PMID:29777701

RGD:155230817

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

ras homolog family member A

multiple interactions

Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]

PMID:9398081 PMID:24587105

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Rhoc

ras homolog family member C

multiple interactions

Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein]

NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306

Rxra

retinoid X receptor alpha

multiple interactions

Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]

PMID:11779144

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

Scd

stearoyl-CoA desaturase

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

Serpinb3

serpin family B member 3

increases expression

Farnesol results in increased expression of SERPINB3 mRNA

NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682

Slc25a20

solute carrier family 25 member 20

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA

NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512

Slc27a1

solute carrier family 27 member 1

multiple interactions

[Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC27A1 mRNA

NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063

Slc27a2

solute carrier family 27 member 2

increases expression

Farnesol analog results in increased expression of SLC27A2 mRNA

NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208

Slc7a11

solute carrier family 7 member 11

increases expression

Farnesol results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

tumor necrosis factor

multiple interactions
increases expression

Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]
Farnesol inhibits the reaction [Acetaminophen results in increased expression of TNF protein]
Farnesol results in increased expression of TNF mRNA

PMID:22343369 PMID:30806763 PMID:37458150

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Ugt1a1

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Farnesol

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Ugt1a2

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of Farnesol

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Ugt1a5

UDP glucuronosyltransferase family 1 member A5

increases glucuronidation

UGT1A4 protein results in increased glucuronidation of Farnesol

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Ugt1a6

UDP glucuronosyltransferase family 1 member A6

increases glucuronidation

UGT1A6 protein results in increased glucuronidation of Farnesol

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Ugt1a9

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Farnesol

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

Ugt2b7

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

UGT2B7 protein results in increased glucuronidation of Farnesol

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

farnesyl diphosphate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akt1

AKT serine/threonine kinase 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

baculoviral IAP repeat-containing 5

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]

PMID:17472962

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Bmp2

bone morphogenetic protein 2

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

caspase 3

multiple interactions

PMID:15200425 PMID:18766339

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cyp17a1

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]

PMID:21918126

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

Fnta

farnesyltransferase, CAAX box, subunit alpha

multiple interactions

[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein]

NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460

Fntb

farnesyltransferase, CAAX box, subunit beta

multiple interactions

[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein]

NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA]

PMID:16005304

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Foxo1

forkhead box O1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate

PMID:17208200

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

HRas proto-oncogene, GTPase

multiple interactions

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

intercellular adhesion molecule 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Il12b

interleukin 12B

multiple interactions

farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein]

PMID:15187114

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

interleukin 1 beta

multiple interactions

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Kras

KRAS proto-oncogene, GTPase

multiple interactions

[FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein]

NCBI chr 4:178,185,418...178,218,484

mitogen activated protein kinase 1

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

matrix metallopeptidase 9

multiple interactions

PMID:19299917

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

mevalonate kinase

decreases activity
decreases chemical synthesis
multiple interactions

PMID:9392419 PMID:24073415

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Pon1

paraoxonase 1

multiple interactions

PMID:14500290 PMID:15690306

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

Rac family small GTPase 1

multiple interactions

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

ras homolog family member A

multiple interactions

PMID:18310456 PMID:18625914

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Runx2

RUNX family transcription factor 2

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

selectin E

multiple interactions

farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

tumor necrosis factor

multiple interactions

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

geraniol

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abcc2

ATP binding cassette subfamily C member 2

multiple interactions

geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 mRNA]; geraniol inhibits the reaction [Fructose results in decreased expression of ABCC2 protein]

PMID:31005848

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

Acaca

acetyl-CoA carboxylase alpha

decreases expression

geraniol results in decreased expression of ACACA mRNA

PMID:26141755

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

Ache

acetylcholinesterase

multiple interactions

geraniol inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; geraniol inhibits the reaction [Streptozocin results in increased activity of ACHE protein]

PMID:24752916 PMID:25199698

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

Acta2

actin alpha 2, smooth muscle

multiple interactions

geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

Actl6a

actin-like 6A

decreases expression

geraniol results in decreased expression of ACTL6A mRNA

NCBI chr 2:115,492,374...115,508,401
Ensembl chr 2:115,492,285...115,508,401

Acvr1

activin A receptor type 1

increases expression

geraniol results in increased expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

Adipoq

adiponectin, C1Q and collagen domain containing

multiple interactions

geraniol inhibits the reaction [Fructose results in decreased secretion of ADIPOQ protein]; geraniol promotes the reaction [Streptozocin results in decreased expression of ADIPOQ protein]

PMID:25679220 PMID:28178614

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

Aff4

ALF transcription elongation factor 4

increases expression

geraniol results in increased expression of AFF4 mRNA

NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751

Ager

advanced glycosylation end product-specific receptor

multiple interactions

geraniol inhibits the reaction [Fructose results in increased expression of AGER protein]

PMID:25679220

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

Ahctf1

AT hook containing transcription factor 1

decreases expression

geraniol results in decreased expression of AHCTF1 mRNA

NCBI chr13:91,481,936...91,536,391
Ensembl chr13:91,481,936...91,536,391

Akr1c1

aldo-keto reductase family 1, member C1

increases expression

geraniol results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

Ap5z1

adaptor related protein complex 5 subunit zeta 1

increases expression

geraniol results in increased expression of AP5Z1 mRNA

NCBI chr12:12,093,834...12,109,043
Ensembl chr12:12,093,834...12,108,511

Apbb2

amyloid beta precursor protein binding family B member 2

increases expression

geraniol results in increased expression of APBB2 mRNA

NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495

Appl1

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

decreases expression

geraniol results in decreased expression of APPL1 mRNA

NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692

Atf3

activating transcription factor 3

increases expression

geraniol results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

Atf4

activating transcription factor 4

multiple interactions

geraniol inhibits the reaction [Rotenone results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

Atf6

activating transcription factor 6

increases expression
multiple interactions

geraniol results in increased expression of ATF6 mRNA
geraniol inhibits the reaction [Rotenone results in increased expression of ATF6 protein]

PMID:27683099 PMID:30141137

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

Atg12

autophagy related 12

multiple interactions

geraniol inhibits the reaction [Rotenone results in decreased expression of ATG12 protein]

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

Atg5

autophagy related 5

multiple interactions

geraniol inhibits the reaction [Rotenone results in decreased expression of ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

Atg7

autophagy related 7

multiple interactions

geraniol inhibits the reaction [Rotenone results in decreased expression of ATG7 protein]

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

Bak1

BCL2-antagonist/killer 1

increases expression

geraniol results in increased expression of BAK1 protein

PMID:12530055

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

Bax

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of BAX protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of BAX protein]
geraniol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]
geraniol results in increased expression of BAX mRNA; geraniol results in increased expression of BAX protein

PMID:21371438 PMID:22760862 PMID:24768735 PMID:29050341 PMID:29745075 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Baz1b

bromodomain adjacent to zinc finger domain, 1B

decreases expression

geraniol results in decreased expression of BAZ1B mRNA

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

Baz2b

bromodomain adjacent to zinc finger domain, 2B

increases expression

geraniol results in increased expression of BAZ2B mRNA

NCBI chr 3:44,384,282...44,681,619
Ensembl chr 3:44,385,474...44,592,908

Bbx

BBX high mobility group box domain containing

increases expression

geraniol results in increased expression of BBX mRNA

NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251

Bcl11a

BCL11 transcription factor A

decreases expression

geraniol results in decreased expression of BCL11A mRNA

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

Bcl2

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of BCL2 protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of BCL2 protein]
geraniol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
geraniol results in decreased expression of BCL2 mRNA; geraniol results in decreased expression of BCL2 protein
geraniol results in increased expression of BCL2 protein

PMID:21371438 PMID:21445532 PMID:22760862 PMID:24768735 PMID:29050341 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2l1

Bcl2-like 1

multiple interactions

geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of BCL2L1 protein]; geraniol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA]

PMID:26695085 PMID:35608392

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

Bcl2l2

Bcl2-like 2

decreases expression

geraniol results in decreased expression of BCL2L2 protein

PMID:21371438

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

Bcl6

BCL6, transcription repressor

increases expression

geraniol results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

Bclaf1

BCL2-associated transcription factor 1

decreases expression

geraniol results in decreased expression of BCLAF1 mRNA

NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832

Bdnf

brain-derived neurotrophic factor

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF mRNA]; geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

baculoviral IAP repeat-containing 5

decreases expression

geraniol results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Bmal1

basic helix-loop-helix ARNT like 1

increases expression

geraniol results in increased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

Bmp6

bone morphogenetic protein 6

increases expression

geraniol results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

Bnip3

BCL2 interacting protein 3

increases expression

geraniol results in increased expression of BNIP3 protein

PMID:21371438

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

Brca1

BRCA1, DNA repair associated

decreases expression

geraniol results in decreased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

Brca2

BRCA2, DNA repair associated

decreases expression

geraniol results in decreased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

Btf3

basic transcription factor 3

decreases expression

geraniol results in decreased expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879

Bub1

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

geraniol results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

Bub1b

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

geraniol results in decreased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

caspase 3

multiple interactions
increases activity
increases expression

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased cleavage of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA]; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CASP3 protein]; geraniol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
geraniol results in increased activity of CASP3 protein
geraniol results in increased expression of CASP3 mRNA; geraniol results in increased expression of CASP3 protein
geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CASP3 protein]
geraniol results in increased expression of CASP3 protein modified form

PMID:21371438 PMID:21907755 PMID:22509279 PMID:24875281 PMID:26154255 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp8

caspase 8

multiple interactions
increases expression

geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA]
geraniol results in increased expression of CASP8 mRNA; geraniol results in increased expression of CASP8 protein

PMID:21907755 PMID:30506710

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

Casp9

caspase 9

multiple interactions
increases expression

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased cleavage of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA]; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CASP9 protein]; geraniol inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]
geraniol results in increased expression of CASP9 mRNA; geraniol results in increased expression of CASP9 protein
geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein]

PMID:21907755 PMID:22509279 PMID:24768735 PMID:26364502 PMID:26695085 More...

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Cat

catalase

multiple interactions
decreases activity
increases activity

geraniol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CAT protein]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CAT protein]
geraniol results in decreased activity of CAT protein
geraniol results in increased activity of CAT protein
geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; geraniol inhibits the reaction [Isoproterenol results in decreased expression of CAT mRNA]; geraniol inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:21907755 PMID:22760862 PMID:23033690 PMID:23399806 PMID:24752916 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Cbfa2t2

CBFA2/RUNX1 partner transcriptional co-repressor 2

increases expression

geraniol results in increased expression of CBFA2T2 mRNA

NCBI chr 3:142,936,945...143,043,205
Ensembl chr 3:142,936,985...143,043,197

Cbfb

core-binding factor subunit beta

decreases expression

geraniol results in decreased expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751

Ccl4

C-C motif chemokine ligand 4

increases secretion

geraniol results in increased secretion of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

Ccna2

cyclin A2

decreases expression

geraniol results in decreased expression of CCNA2 mRNA; geraniol results in decreased expression of CCNA2 protein

PMID:17138864 PMID:27683099

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

Ccnb1

cyclin B1

decreases expression

geraniol results in decreased expression of CCNB1 protein

PMID:17138864 PMID:21371438

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

Ccnd1

cyclin D1

decreases expression

geraniol results in decreased expression of CCND1 protein

PMID:15450939

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Cd86

CD86 molecule

increases expression

geraniol results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

Cdc20

cell division cycle 20

decreases expression

geraniol results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

Cdc25a

cell division cycle 25A

decreases expression

geraniol results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

Cdc25c

cell division cycle 25C

decreases expression

geraniol results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

Cdc45

cell division cycle 45

decreases expression

geraniol results in decreased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

Cdc7

cell division cycle 7

decreases expression

geraniol results in decreased expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

Cdh1

cadherin 1

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

Cdk1

cyclin-dependent kinase 1

decreases expression

geraniol results in decreased expression of CDK1 protein

PMID:21371438

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

Cdk2

cyclin dependent kinase 2

decreases expression
multiple interactions

geraniol results in decreased expression of CDK2 mRNA; geraniol results in decreased expression of CDK2 protein
geraniol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; geraniol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]

PMID:15450939 PMID:17138864 PMID:27683099

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

Cdk4

cyclin-dependent kinase 4

decreases expression

geraniol results in decreased expression of CDK4 protein

PMID:15450939 PMID:21371438

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

Cdkn1a

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions
increases response to substance

geraniol results in increased expression of CDKN1A protein
geraniol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
CDKN1A protein results in increased susceptibility to geraniol

PMID:17138864 PMID:21371438

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn1b

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions
increases response to substance

geraniol results in increased expression of CDKN1B protein
geraniol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CDKN1B protein results in increased susceptibility to geraniol

PMID:17138864 PMID:21371438

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

Cdkn2c

cyclin-dependent kinase inhibitor 2C

decreases expression

geraniol results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

Cdkn3

cyclin-dependent kinase inhibitor 3

decreases expression

geraniol results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

Cdt1

chromatin licensing and DNA replication factor 1

decreases expression

geraniol results in decreased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

Cebpb

CCAAT/enhancer binding protein beta

increases expression

geraniol results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

Cebpg

CCAAT/enhancer binding protein gamma

increases expression

geraniol results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

Cenpe

centromere protein E

decreases expression

geraniol results in decreased expression of CENPE mRNA

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

Cenpf

centromere protein F

decreases expression

geraniol results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

Chek1

checkpoint kinase 1

decreases expression

geraniol results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

Cit

citron rho-interacting serine/threonine kinase

decreases expression

geraniol results in decreased expression of CIT mRNA

NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860

Ckm

creatine kinase, M-type

multiple interactions

geraniol inhibits the reaction [Doxorubicin results in increased activity of CKM protein]

PMID:34343525

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

Cnbp

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

geraniol results in decreased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

Cnga2

cyclic nucleotide gated channel subunit alpha 2

multiple interactions

CNGA2 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]

PMID:29070885

NCBI chr X:149,696,999...149,715,051
Ensembl chr X:149,696,997...149,715,051

Col1a1

collagen type I alpha 1 chain

multiple interactions

geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Cox7c

cytochrome c oxidase subunit 7C

multiple interactions

geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA]

PMID:24768735

NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760

Creb3

cAMP responsive element binding protein 3

increases expression

geraniol results in increased expression of CREB3 mRNA

NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390

Creb3l2

cAMP responsive element binding protein 3-like 2

increases expression

geraniol results in increased expression of CREB3L2 mRNA

NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763

Crp

C-reactive protein

multiple interactions

geraniol inhibits the reaction [Isoproterenol results in increased expression of CRP protein]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

Ctnnb1

catenin beta 1

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CTNNB1 mRNA]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]

PMID:26165751 PMID:28428697

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

Ctsd

cathepsin D

multiple interactions

geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CTSD protein]

PMID:23499697

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

Cyb5a

cytochrome b5 type A

multiple interactions

geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein]

PMID:23499697

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

Cybb

cytochrome b-245 beta chain

multiple interactions

geraniol inhibits the reaction [Dietary Fats results in increased expression of CYBB protein]
geraniol inhibits the reaction [Palmitic Acid results in increased expression of CYBB protein]

PMID:27107694

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

Cyc1

cytochrome c-1

multiple interactions

geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein]

PMID:24768735

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases metabolic processing

[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral metabolite; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite; [CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol; [CYP1A1 protein results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; [CYP1A1 protein results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite

PMID:18824010

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

PMID:18824010

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

Cyp2b3

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases metabolic processing

[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral metabolite; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite; [CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol; [CYP2B6 protein results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; geraniol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]

PMID:18611395 PMID:18824010

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP2E1 protein]
[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral metabolite; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite; [CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol

PMID:18824010 PMID:26695085

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

Cyp3a9

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing
multiple interactions

CYP3A5 protein results in increased metabolism of geraniol
[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral metabolite; [[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite; [CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol; [CYP3A5 protein results in increased metabolism of geraniol] which results in increased chemical synthesis of citral; [CYP3A5 protein results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite

PMID:18824010

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

Dbf4

DBF4-CDC7 kinase regulatory subunit

decreases expression

geraniol results in decreased expression of DBF4 mRNA

NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066

Ddit3

DNA-damage inducible transcript 3

increases expression
multiple interactions

geraniol results in increased expression of DDIT3 mRNA
geraniol inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]

PMID:27683099 PMID:30141137

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

Dek

DEK proto-oncogene

decreases expression

geraniol results in decreased expression of DEK mRNA

NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808

Dmtf1

cyclin D binding myb-like transcription factor 1

increases expression

geraniol results in increased expression of DMTF1 mRNA

NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967

Dnajc1

DnaJ heat shock protein family (Hsp40) member C1

increases expression

geraniol results in increased expression of DNAJC1 mRNA

NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988

Dr1

down-regulator of transcription 1

decreases expression

geraniol results in decreased expression of DR1 mRNA

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

Dtymk

deoxythymidylate kinase

decreases expression

geraniol results in decreased expression of DTYMK mRNA

NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870

E2f1

E2F transcription factor 1

decreases expression

geraniol results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

E2f8

E2F transcription factor 8

decreases expression

geraniol results in decreased expression of E2F8 mRNA; geraniol results in decreased expression of E2F8 protein

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

Ehf

ets homologous factor

decreases expression

geraniol results in decreased expression of EHF mRNA

NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997

Eif2ak3

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

geraniol inhibits the reaction [Rotenone results in increased expression of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

Eif2s1

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

geraniol inhibits the reaction [Rotenone results in increased expression of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

Elavl2

ELAV like RNA binding protein 2

decreases expression

geraniol results in decreased expression of ELAVL2 mRNA

NCBI chr 5:105,960,872...106,086,463
Ensembl chr 5:105,960,875...106,109,097

Elf1

E74 like ETS transcription factor 1

increases expression

geraniol results in increased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

Elk4

ETS transcription factor ELK4

increases expression

geraniol results in increased expression of ELK4 mRNA

NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035

Erc1

ELKS/RAB6-interacting/CAST family member 1

increases expression

geraniol results in increased expression of ERC1 mRNA

NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639

Ern1

endoplasmic reticulum to nucleus signaling 1

multiple interactions

geraniol inhibits the reaction [Rotenone results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

Espl1

extra spindle pole bodies like 1, separase

decreases expression

geraniol results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

Esr1

estrogen receptor 1

affects binding
multiple interactions

geraniol binds to ESR1 protein
geraniol inhibits the reaction [Estradiol binds to ESR1 protein]

PMID:12495555

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

Esr2

estrogen receptor 2

affects binding
multiple interactions

geraniol binds to ESR2 protein
geraniol inhibits the reaction [Estradiol binds to ESR2 protein]

PMID:12495555

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

Ets2

ETS proto-oncogene 2, transcription factor

increases expression

geraniol results in increased expression of ETS2 mRNA

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

Etv1

ETS variant transcription factor 1

decreases expression

geraniol results in decreased expression of ETV1 mRNA

NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775

Ewsr1

EWS RNA-binding protein 1

decreases expression

geraniol results in decreased expression of EWSR1 mRNA

NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544

Ezh2

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

geraniol results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

Fabp4

fatty acid binding protein 4

increases expression

geraniol results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

Fads1

fatty acid desaturase 1

multiple interactions
decreases activity

[geraniol results in decreased activity of FADS1 protein] which results in decreased chemical synthesis of Arachidonic Acid; [geraniol results in decreased activity of FADS1 protein] which results in decreased metabolism of 8,11,14-Eicosatrienoic Acid

PMID:16462894

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

Fancg

FA complementation group G

decreases expression

geraniol results in decreased expression of FANCG mRNA

NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029

Fasn

fatty acid synthase

multiple interactions

geraniol promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Fbxo5

F-box protein 5

decreases expression

geraniol results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

geraniol results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fosl1

FOS like 1, AP-1 transcription factor subunit

decreases expression

geraniol results in decreased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

Fosl2

FOS like 2, AP-1 transcription factor subunit

increases expression

geraniol results in increased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

Foxa2

forkhead box A2

decreases expression

geraniol results in decreased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

Foxj3

forkhead box J3

increases expression

geraniol results in increased expression of FOXJ3 mRNA

NCBI chr 5:133,140,344...133,228,489
Ensembl chr 5:133,140,884...133,228,489

Foxm1

forkhead box M1

decreases expression

geraniol results in decreased expression of FOXM1 mRNA

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

Foxo4

forkhead box O4

increases expression

geraniol results in increased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

Fst

follistatin

increases expression

geraniol results in increased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

Fubp1

far upstream element binding protein 1

decreases expression

geraniol results in decreased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G6pd

glucose-6-phosphate dehydrogenase

multiple interactions

geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of G6PD protein]
geraniol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]

PMID:23399806 PMID:28330423

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

Gatad1

GATA zinc finger domain containing 1

increases expression

geraniol results in increased expression of GATAD1 mRNA

NCBI chr 4:30,507,530...30,519,107
Ensembl chr 4:30,507,538...30,519,107

Gbx2

gastrulation brain homeobox 2

decreases expression

geraniol results in decreased expression of GBX2 mRNA

NCBI chr 9:90,509,633...90,512,212
Ensembl chr 9:90,509,633...90,512,212

Gcg

glucagon

multiple interactions
increases secretion

9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein]; CNGA2 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]; GNAL mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]; OR1A1 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]; OR1G1 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]

PMID:29070885

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

Gdnf

glial cell derived neurotrophic factor

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]; geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

Gmnn

geminin, DNA replication inhibitor

decreases expression

geraniol results in decreased expression of GMNN mRNA

NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054

Gna15

G protein subunit alpha 15

increases response to substance
multiple interactions

GNA15 protein results in increased susceptibility to geraniol
[GNA15 protein results in increased susceptibility to geraniol] which results in increased activity of OR1A1B protein

PMID:15598656

NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508

Gnal

G protein subunit alpha L

increases response to substance
multiple interactions

GNAL protein results in increased susceptibility to geraniol
[GNAL protein results in increased susceptibility to geraniol] which results in increased activity of OR1A1B protein; GNAL mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]

PMID:15598656 PMID:29070885

NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599

Got1

glutamic-oxaloacetic transaminase 1

multiple interactions

geraniol inhibits the reaction [Doxorubicin results in increased activity of GOT1 protein]

PMID:34343525

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

Gpt

glutamic--pyruvic transaminase

multiple interactions

geraniol inhibits the reaction [Doxorubicin results in increased activity of GPT protein]

PMID:34343525

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Gpx1

glutathione peroxidase 1

multiple interactions

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of GPX1 mRNA]

PMID:22509279

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

Gsk3b

glycogen synthase kinase 3 beta

multiple interactions

geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]

PMID:26165751

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

Gsr

glutathione-disulfide reductase

multiple interactions
decreases activity

geraniol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GSR protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of GSR protein]
geraniol results in decreased activity of GSR protein
[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased activity of GSR protein]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of GSR mRNA]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein]; geraniol inhibits the reaction [Streptozocin affects the activity of GSR protein]

PMID:22509279 PMID:22760862 PMID:23033690 PMID:23399806 PMID:24752916 More...

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Gstp1

glutathione S-transferase pi 1

multiple interactions

geraniol inhibits the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]

PMID:27046949

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Gtf2b

general transcription factor IIB

increases expression

geraniol results in increased expression of GTF2B mRNA

NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651

Gtf2h1

general transcription factor IIH subunit 1

increases expression

geraniol results in increased expression of GTF2H1 mRNA

NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455

Gtf2ird1

GTF2I repeat domain containing 1

increases expression

geraniol results in increased expression of GTF2IRD1 mRNA

NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040

Gtf3a

general transcription factor III A

decreases expression

geraniol results in decreased expression of GTF3A mRNA

NCBI chr12:8,136,746...8,144,690
Ensembl chr12:8,136,747...8,144,690

Gtf3c1

general transcription factor IIIC subunit 1

increases expression

geraniol results in increased expression of GTF3C1 mRNA

NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201

Havcr1

hepatitis A virus cellular receptor 1

multiple interactions

geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]

PMID:21907755

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

Hbb

hemoglobin subunit beta

multiple interactions

geraniol inhibits the reaction [Fructose promotes the reaction [Glucose binds to HBB protein]]

PMID:25679220

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

Hbp1

HMG-box transcription factor 1

increases expression

geraniol results in increased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

Hivep1

HIVEP zinc finger 1

increases expression

geraniol results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

Hlf

HLF transcription factor, PAR bZIP family member

decreases expression

geraniol results in decreased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

Hmbox1

homeobox containing 1

increases expression

geraniol results in increased expression of HMBOX1 mRNA

NCBI chr15:39,067,805...39,200,633
Ensembl chr15:39,067,804...39,200,323

Hmg20b

high mobility group 20 B

decreases expression

geraniol results in decreased expression of HMG20B mRNA

NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640

Hmgb2

high mobility group box 2

decreases expression

geraniol results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

Hmgb3

high mobility group box 3

decreases expression

geraniol results in decreased expression of HMGB3 mRNA

NCBI chr X:149,296,303...149,301,290
Ensembl chr X:149,296,375...149,301,292

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
decreases expression
affects expression
decreases activity

geraniol results in increased expression of HMGCR mRNA
geraniol results in decreased expression of HMGCR protein
geraniol affects the expression of HMGCR mRNA
geraniol results in decreased activity of HMGCR protein

PMID:12477733 PMID:15450939 PMID:16462894 PMID:23668785 PMID:24875281 More...

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

Hmgxb3

HMG-box containing 3

increases expression

geraniol results in increased expression of HMGXB3 mRNA

NCBI chr18:54,590,558...54,638,050
Ensembl chr18:54,590,560...54,638,155

Hmgxb4

HMG-box containing 4

decreases expression

geraniol results in decreased expression of HMGXB4 mRNA

NCBI chr19:13,364,741...13,403,563
Ensembl chr19:13,364,807...13,403,563

Hmox1

heme oxygenase 1

increases expression
multiple interactions

geraniol results in increased expression of HMOX1 mRNA
geraniol promotes the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; geraniol promotes the reaction [Doxorubicin results in increased expression of HMOX1 protein]
geraniol results in increased expression of HMOX1 protein

PMID:20713136 PMID:28334550 PMID:30806763 PMID:34343525

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hnrnpab

heterogeneous nuclear ribonucleoprotein A/B

decreases expression

geraniol results in decreased expression of HNRNPAB mRNA

NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344

Hoxa5

homeo box A5

increases expression

geraniol results in increased expression of HOXA5 mRNA

NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234

Hoxb13

homeo box B13

decreases expression

geraniol results in decreased expression of HOXB13 mRNA

NCBI chr10:81,160,498...81,162,777
Ensembl chr10:81,160,498...81,162,777

Hoxc6

homeo box C6

increases expression

geraniol results in increased expression of HOXC6 mRNA

NCBI chr 7:134,138,017...134,148,899
Ensembl chr 7:134,135,502...134,148,392

HRas proto-oncogene, GTPase

multiple interactions

[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with geraniol] affects the localization of HRAS protein

PMID:22760862

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

Hspa2

heat shock protein family A (Hsp70) member 2

decreases expression

geraniol results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

Htr3a

5-hydroxytryptamine receptor 3A

decreases activity

geraniol results in decreased activity of HTR3A protein

PMID:26456648

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

intercellular adhesion molecule 1

multiple interactions

geraniol inhibits the reaction [Dietary Fats results in increased expression of ICAM1 protein]
geraniol inhibits the reaction [Palmitic Acid results in increased expression of ICAM1 protein]
geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]

PMID:26165751 PMID:27107694

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Id1

inhibitor of DNA binding 1

increases expression

geraniol results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

Id3

inhibitor of DNA binding 3

increases expression

geraniol results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

Ifng

interferon gamma

multiple interactions

geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]

PMID:26973525

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Il10

interleukin 10

increases expression
multiple interactions

geraniol results in increased expression of IL10 protein
geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IL10 protein]

PMID:24934659 PMID:26973525

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il16

interleukin 16

increases secretion

geraniol results in increased secretion of IL16 protein

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

Il17a

interleukin 17A

multiple interactions

geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]

PMID:26973525

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

Il18

interleukin 18

multiple interactions

geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]
geraniol inhibits the reaction [Doxorubicin results in increased expression of IL18 protein]

PMID:21430599 PMID:34343525

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

Il1a

interleukin 1 alpha

increases expression

geraniol results in increased expression of IL1A protein

PMID:19878710

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

interleukin 1 beta

multiple interactions

geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of IL1B protein]; geraniol inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL1B protein]; geraniol inhibits the reaction [Fructose results in increased secretion of IL1B protein]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of IL1B protein]]; geraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; geraniol inhibits the reaction [ovalbumin-alum results in increased expression of and results in increased secretion of IL1B protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]
geraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of and results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]

PMID:20304105 PMID:21282739 PMID:21430599 PMID:23399806 PMID:25679220 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1r2

interleukin 1 receptor type 2

increases expression

geraniol results in increased expression of IL1R2 mRNA

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

Il6

interleukin 6

multiple interactions
increases expression

geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; geraniol inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein]
geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of and results in increased secretion of IL6 protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]
geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; geraniol inhibits the reaction [Fructose results in increased expression of IL6 protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]
geraniol results in increased expression of IL6 mRNA

PMID:23399806 PMID:26190278 PMID:26695085 PMID:26973525 PMID:27107694 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Il7r

interleukin 7 receptor

increases expression

geraniol results in increased expression of IL7R mRNA

PMID:20713136

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

Ilf2

interleukin enhancer binding factor 2

decreases expression

geraniol results in decreased expression of ILF2 mRNA

NCBI chr 2:175,952,174...175,971,191
Ensembl chr 2:175,952,186...175,971,337

Ins1

insulin 1

increases secretion
multiple interactions

geraniol results in increased secretion of INS1 protein
geraniol inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]

PMID:28330423 PMID:29070885

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

Irf1

interferon regulatory factor 1

increases expression

geraniol results in increased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

Irf6

interferon regulatory factor 6

increases expression

geraniol results in increased expression of IRF6 mRNA

NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386

Irf7

interferon regulatory factor 7

increases expression

geraniol results in increased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

Irf9

interferon regulatory factor 9

increases expression

geraniol results in increased expression of IRF9 mRNA

NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236

Jarid2

jumonji and AT-rich interaction domain containing 2

increases expression

geraniol results in increased expression of JARID2 mRNA

NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690

Jmjd1c

jumonji domain containing 1C

increases expression

geraniol results in increased expression of JMJD1C mRNA

NCBI chr20:21,332,147...21,494,220
Ensembl chr20:21,332,147...21,463,122

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

geraniol results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Junb

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

geraniol results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

Jund

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

geraniol results in increased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

Kdr

kinase insert domain receptor

decreases expression

geraniol results in decreased expression of KDR protein

PMID:26154255

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

Khdrbs1

KH RNA binding domain containing, signal transduction associated 1

decreases expression

geraniol results in decreased expression of KHDRBS1 mRNA

NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180

Kif11

kinesin family member 11

decreases expression

geraniol results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

Kif15

kinesin family member 15

decreases expression

geraniol results in decreased expression of KIF15 mRNA

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

Kif22

kinesin family member 22

decreases expression

geraniol results in decreased expression of KIF22 mRNA

NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401

Kif23

kinesin family member 23

decreases expression

geraniol results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

Kif2c

kinesin family member 2C

decreases expression

geraniol results in decreased expression of KIF2C mRNA

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

Klf11

KLF transcription factor 11

increases expression

geraniol results in increased expression of KLF11 mRNA

NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550

Klf13

KLF transcription factor 13

increases expression

geraniol results in increased expression of KLF13 mRNA

NCBI chr 1:117,505,857...117,536,626
Ensembl chr 1:117,503,602...117,551,227

Klf3

KLF transcription factor 3

increases expression

geraniol results in increased expression of KLF3 mRNA

NCBI chr14:43,474,767...43,505,801
Ensembl chr14:43,474,767...43,497,209

Klf4

KLF transcription factor 4

increases expression

geraniol results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

Klf5

KLF transcription factor 5

increases expression

geraniol results in increased expression of KLF5 mRNA

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

Klf6

KLF transcription factor 6

increases expression

geraniol results in increased expression of KLF6 mRNA

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

Klf7

KLF transcription factor 7

increases expression

geraniol results in increased expression of KLF7 mRNA

NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261

Kntc1

kinetochore associated 1

decreases expression

geraniol results in decreased expression of KNTC1 mRNA

NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561

Kras

KRAS proto-oncogene, GTPase

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KRAS mRNA]

NCBI chr 4:178,185,418...178,218,484

Ldlr

low density lipoprotein receptor

increases expression

geraniol results in increased expression of LDLR mRNA

PMID:26141755

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

Lif

LIF, interleukin 6 family cytokine

decreases expression

geraniol results in decreased expression of LIF protein

PMID:19878710

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

Lztfl1

leucine zipper transcription factor-like 1

increases expression

geraniol results in increased expression of LZTFL1 mRNA

NCBI chr 8:123,344,085...123,360,245
Ensembl chr 8:123,344,925...123,360,192

Lztr1

leucine zipper like post translational regulator 1

increases expression

geraniol results in increased expression of LZTR1 mRNA

NCBI chr11:83,487,717...83,503,896
Ensembl chr11:83,487,717...83,503,633

Mad2l1

mitotic arrest deficient 2 like 1

decreases expression

geraniol results in decreased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

Maff

MAF bZIP transcription factor F

increases expression

geraniol results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

Mafg

MAF bZIP transcription factor G

increases expression

geraniol results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

Maob

monoamine oxidase B

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOB protein]

PMID:24103762

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

Map2k1

mitogen activated protein kinase kinase 1

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased phosphorylation of MAPK1 protein]
geraniol results in decreased phosphorylation of MAPK1 protein

PMID:12388655 PMID:22760862 PMID:26154255

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased phosphorylation of MAPK3 protein]
geraniol inhibits the reaction [Isoproterenol results in increased expression of MAPK3 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]
geraniol results in decreased phosphorylation of MAPK3 protein

PMID:12388655 PMID:22760862 PMID:26154255 PMID:35608392

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

multiple interactions

geraniol inhibits the reaction [Isoproterenol results in increased expression of MAPK8 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mcm2

minichromosome maintenance complex component 2

decreases expression

geraniol results in decreased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

Mef2a

myocyte enhancer factor 2a

increases expression

geraniol results in increased expression of MEF2A mRNA

NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948

Men1

menin 1

increases expression

geraniol results in increased expression of MEN1 mRNA

NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871

Mki67

marker of proliferation Ki-67

decreases expression

geraniol results in decreased expression of MKI67 mRNA
geraniol results in decreased expression of MKI67 protein

PMID:26154255 PMID:27683099

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

Mmp2

matrix metallopeptidase 2

multiple interactions

geraniol inhibits the reaction [Isoproterenol results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

Mmp3

matrix metallopeptidase 3

increases expression

geraniol results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

matrix metallopeptidase 9

multiple interactions

geraniol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mnt

MAX network transcriptional repressor

increases expression

geraniol results in increased expression of MNT mRNA

NCBI chr10:59,699,208...59,714,848
Ensembl chr10:59,699,585...59,714,835

Mpo

myeloperoxidase

multiple interactions

2-chloro-5-nitrobenzanilide inhibits the reaction [geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of MPO protein]]; geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased activity of MPO protein]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
geraniol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein]; geraniol inhibits the reaction [Cysteamine results in increased expression of MPO protein]; geraniol inhibits the reaction [Ethanol results in increased expression of MPO protein]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]

PMID:24337826 PMID:26165751 PMID:26190278 PMID:30550845

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Mtor

mechanistic target of rapamycin kinase

decreases activity
multiple interactions

geraniol results in decreased activity of MTOR protein
geraniol inhibits the reaction [Rotenone results in increased phosphorylation of MTOR protein]

PMID:22200837 PMID:30141137

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

mevalonate kinase

multiple interactions

geraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; geraniol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]

PMID:20304105

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Mxd1

max dimerization protein 1

increases expression

geraniol results in increased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

Mxd4

Max dimerization protein 4

increases expression

geraniol results in increased expression of MXD4 mRNA

NCBI chr14:76,562,105...76,576,224
Ensembl chr14:76,561,774...76,576,221

Mxi1

MAX interactor 1, dimerization protein

increases expression

geraniol results in increased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

Myb

MYB proto-oncogene, transcription factor

decreases expression

geraniol results in decreased expression of MYB mRNA

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

Mybl1

MYB proto-oncogene like 1

decreases expression

geraniol results in decreased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

Mybl2

MYB proto-oncogene like 2

decreases expression

geraniol results in decreased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

Myo6

myosin VI

increases expression

geraniol results in increased expression of MYO6 mRNA

NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292

Nasp

nuclear autoantigenic sperm protein

decreases expression

geraniol results in decreased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

Ncaph

non-SMC condensin I complex, subunit H

decreases expression

geraniol results in decreased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

Ncor1

nuclear receptor co-repressor 1

increases expression

geraniol results in increased expression of NCOR1 mRNA

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

Ndp

norrin cystine knot growth factor NDP

decreases expression

geraniol results in decreased expression of NDP mRNA

NCBI chr X:5,796,487...5,820,934
Ensembl chr X:5,796,487...5,820,934

Nek2

NIMA-related kinase 2

decreases expression

geraniol results in decreased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

Nfat5

nuclear factor of activated T-cells 5

increases expression

geraniol results in increased expression of NFAT5 mRNA

NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675

Nfe2l1

NFE2 like bZIP transcription factor 1

increases expression

geraniol results in increased expression of NFE2L1 mRNA

NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318

Nfe2l2

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

geraniol results in increased expression of NFE2L2 mRNA
geraniol promotes the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA]; geraniol promotes the reaction [Doxorubicin results in increased expression of NFE2L2 protein]
geraniol results in increased expression of NFE2L2 protein

PMID:27683099 PMID:28334550 PMID:34343525

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

Nfil3

nuclear factor, interleukin 3 regulated

increases expression

geraniol results in increased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

Nfkb1

nuclear factor kappa B subunit 1

multiple interactions

geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]

PMID:21907755 PMID:26165751

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

multiple interactions

geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of NFKBIA mRNA]; geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of NFKBIA protein modified form]; geraniol inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFKBIA protein modified form]; geraniol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
geraniol inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of NFKBIA protein]

PMID:20506077 PMID:26190278 PMID:29050341 PMID:30550845 PMID:34343525

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Nfyb

nuclear transcription factor Y subunit beta

decreases expression

geraniol results in decreased expression of NFYB mRNA

NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565

Nos2

nitric oxide synthase 2

multiple interactions
decreases expression

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased expression of NOS2 mRNA]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein]; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NOS2 protein]
geraniol results in decreased expression of NOS2 mRNA; geraniol results in decreased expression of NOS2 protein
geraniol inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]

PMID:20506077 PMID:22509279 PMID:26190278 PMID:26364502 PMID:26695085 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Nox1

NADPH oxidase 1

multiple interactions

geraniol inhibits the reaction [Palmitic Acid results in increased expression of NOX1 protein]

PMID:27107694

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

Npm1

nucleophosmin 1

decreases expression

geraniol results in decreased expression of NPM1 mRNA

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

Nqo1

NAD(P)H quinone dehydrogenase 1

multiple interactions

geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein]; geraniol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]

PMID:23499697 PMID:34343525

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Nr1d1

nuclear receptor subfamily 1, group D, member 1

increases expression

geraniol results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

Nr1d2

nuclear receptor subfamily 1, group D, member 2

increases expression

geraniol results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

Nr2f1

nuclear receptor subfamily 2, group F, member 1

decreases expression

geraniol results in decreased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

Nr3c1

nuclear receptor subfamily 3, group C, member 1

increases expression

geraniol results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

Nr4a2

nuclear receptor subfamily 4, group A, member 2

increases expression

geraniol results in increased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

Nsd2

nuclear receptor binding SET domain protein 2

decreases expression

geraniol results in decreased expression of NSD2 mRNA

NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641

Nusap1

nucleolar and spindle associated protein 1

decreases expression

geraniol results in decreased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

Odc1

ornithine decarboxylase 1

multiple interactions
decreases activity

geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 protein]
geraniol results in decreased activity of ODC1 protein

PMID:11408542 PMID:22760862

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

Ogg1

8-oxoguanine DNA glycosylase

multiple interactions

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in increased expression of OGG1 protein]

PMID:22509279

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

Or1a1

olfactory receptor family 1 subfamily A member 1

multiple interactions

[GNA15 protein results in increased susceptibility to geraniol] which results in increased activity of OR1A1B protein; [GNAL protein results in increased susceptibility to geraniol] which results in increased activity of OR1A1B protein; OR1A1 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]

PMID:15598656 PMID:29070885

NCBI chr10:59,058,941...59,059,879
Ensembl chr10:59,052,828...59,060,676

Or1ad5

olfactory receptor family 1 subfamily AD member 5

multiple interactions

OR1G1 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]

PMID:29070885

NCBI chr10:35,307,662...35,308,573
Ensembl chr10:35,304,703...35,308,919

Pa2g4

proliferation-associated 2G4

decreases expression

geraniol results in decreased expression of PA2G4 mRNA

NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331

Pbx1

PBX homeobox 1

decreases expression

geraniol results in decreased expression of PBX1 mRNA

NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594

Pcna

proliferating cell nuclear antigen

multiple interactions
decreases expression

geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein]; geraniol inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]; geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
geraniol results in decreased expression of PCNA protein

PMID:21907755 PMID:26154255 PMID:26364502 PMID:27046949 PMID:28428697

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

Pgr

progesterone receptor

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

Phb1

prohibitin 1

decreases expression
multiple interactions

geraniol results in decreased expression of PHB1 mRNA
geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PHB1 protein]

PMID:26695085 PMID:27683099

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

Phf1

PHD finger protein 1

increases expression

geraniol results in increased expression of PHF1 mRNA

NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871

Phf21a

PHD finger protein 21A

increases expression

geraniol results in increased expression of PHF21A mRNA

NCBI chr 3:78,158,760...78,331,903
Ensembl chr 3:78,194,549...78,331,865

Phtf1

putative homeodomain transcription factor 1

increases expression

geraniol results in increased expression of PHTF1 mRNA

NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078

Pik3r1

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

Pkmyt1

protein kinase, membrane associated tyrosine/threonine 1

decreases expression

geraniol results in decreased expression of PKMYT1 mRNA

NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995

Plagl1

PLAG1 like zinc finger 1

increases expression

geraniol results in increased expression of PLAGL1 mRNA

NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228

Plk1

polo-like kinase 1

decreases expression

geraniol results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

Pola1

DNA polymerase alpha 1, catalytic subunit

decreases expression

geraniol results in decreased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

Pole

DNA polymerase epsilon, catalytic subunit

decreases expression

geraniol results in decreased expression of POLE mRNA

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

Polr1g

RNA polymerase I subunit G

decreases expression

geraniol results in decreased expression of POLR1G mRNA

NCBI chr 1:79,007,490...79,010,766
Ensembl chr 1:79,007,490...79,010,766

Por

cytochrome p450 oxidoreductase

multiple interactions

geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of POR protein]

PMID:23499697

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

Ppara

peroxisome proliferator activated receptor alpha

multiple interactions
increases activity

geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]
geraniol results in increased activity of PPARA protein

PMID:21597168 PMID:26695085

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

Pparg

peroxisome proliferator-activated receptor gamma

decreases expression
increases activity
multiple interactions

geraniol results in decreased expression of PPARG mRNA
geraniol results in increased activity of PPARG protein
geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in decreased expression of PPARG mRNA]; geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in decreased expression of PPARG protein]
geraniol inhibits the reaction [Fructose results in decreased activity of PPARG protein]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]

PMID:21597168 PMID:25679220 PMID:26165751 PMID:27683099 PMID:30550845

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Prc1

protein regulator of cytokinesis 1

decreases expression

geraniol results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

Prdm4

PR/SET domain 4

increases expression

geraniol results in increased expression of PRDM4 mRNA

NCBI chr 7:17,953,832...17,980,489
Ensembl chr 7:17,954,019...17,980,489

Prdx1

peroxiredoxin 1

multiple interactions

geraniol inhibits the reaction [Isoproterenol results in decreased expression of PRDX1 mRNA]; geraniol inhibits the reaction [Isoproterenol results in decreased expression of PRDX1 protein]

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

Prdx3

peroxiredoxin 3

decreases expression

geraniol results in decreased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

Prkaa1

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

geraniol inhibits the reaction [Rotenone results in increased expression of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

Pten

phosphatase and tensin homolog

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

Ptgs2

prostaglandin-endoperoxide synthase 2

multiple interactions

geraniol inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; geraniol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein]

PMID:20506077 PMID:21597168 PMID:22760862 PMID:23399806 PMID:26190278 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Pttg1

PTTG1 regulator of sister chromatid separation, securin

decreases expression

geraniol results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

Pwp1

PWP1 homolog, endonuclein

decreases expression

geraniol results in decreased expression of PWP1 mRNA

NCBI chr 7:17,982,730...17,998,728
Ensembl chr 7:17,982,235...17,998,731

Racgap1

Rac GTPase-activating protein 1

decreases expression

geraniol results in decreased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

Rad51

RAD51 recombinase

decreases expression

geraniol results in decreased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

Rad54b

RAD54 homolog B

decreases expression

geraniol results in decreased expression of RAD54B mRNA

NCBI chr 5:25,032,112...25,104,630
Ensembl chr 5:25,032,066...25,104,616

Rad54l

RAD54 like

decreases expression

geraniol results in decreased expression of RAD54L mRNA

NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070

Raf1

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of RAF1 protein]

PMID:22760862

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

Rcan1

regulator of calcineurin 1

increases expression

geraniol results in increased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

Rcor3

REST corepressor 3

increases expression

geraniol results in increased expression of RCOR3 mRNA

NCBI chr13:103,624,966...103,665,565
Ensembl chr13:103,624,971...103,665,565

Rela

RELA proto-oncogene, NF-kB subunit

multiple interactions

geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of RELA mRNA]; geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of RELA protein modified form]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of and affects the localization of and results in increased activity of RELA protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein modified form]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein]
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein]; geraniol inhibits the reaction [Doxorubicin results in increased expression of RELA protein]

PMID:23399806 PMID:26190278 PMID:26364502 PMID:28397014 PMID:29050341 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Rfx5

regulatory factor X5

increases expression

geraniol results in increased expression of RFX5 mRNA

NCBI chr 2:182,521,191...182,528,720
Ensembl chr 2:182,521,202...182,528,717

Rnf19a

ring finger protein 19A, RBR E3 ubiquitin protein ligase

increases expression

geraniol results in increased expression of RNF19A mRNA

NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222

Ruvbl1

RuvB-like AAA ATPase 1

decreases expression

geraniol results in decreased expression of RUVBL1 mRNA

NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384

Ruvbl2

RuvB-like AAA ATPase 2

decreases expression

geraniol results in decreased expression of RUVBL2 mRNA

NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342

Satb1

SATB homeobox 1

increases expression

geraniol results in increased expression of SATB1 mRNA

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

Serpinb3

serpin family B member 3

increases expression

geraniol results in increased expression of SERPINB3 mRNA

NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682

Sim2

SIM bHLH transcription factor 2

increases expression

geraniol results in increased expression of SIM2 mRNA

NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663

Sirt1

sirtuin 1

increases expression

geraniol results in increased expression of SIRT1 mRNA

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

Skp2

S-phase kinase associated protein 2

decreases expression

geraniol results in decreased expression of SKP2 mRNA

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

Slc18a2

solute carrier family 18 member A2

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

Slc2a4rg

SLC2A4 regulator

decreases expression

geraniol results in decreased expression of SLC2A4RG mRNA

NCBI chr 3:168,493,975...168,497,616

Slc6a3

solute carrier family 6 member 3

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

Smad3

SMAD family member 3

decreases expression

geraniol results in decreased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

Smad6

SMAD family member 6

decreases expression

geraniol results in decreased expression of SMAD6 mRNA

NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763

Smad7

SMAD family member 7

increases expression

geraniol results in increased expression of SMAD7 mRNA

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

Smarca2

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

decreases expression

geraniol results in decreased expression of SMARCA2 mRNA

NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684

Smarcal1

SNF2 related chromatin remodeling annealing helicase 1

increases expression

geraniol results in increased expression of SMARCAL1 mRNA

NCBI chr 9:74,239,718...74,286,156
Ensembl chr 9:74,240,241...74,286,146

Smc4

structural maintenance of chromosomes 4

decreases expression

geraniol results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

Snca

synuclein alpha

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]; geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]
geraniol inhibits the reaction [Rotenone results in increased expression of SNCA protein]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Dopamine]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; geraniol inhibits the reaction [SNCA protein results in increased abundance of Thiobarbituric Acid Reactive Substances]

PMID:24103762 PMID:27026137 PMID:30141137

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

Sod1

superoxide dismutase 1

multiple interactions

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of SOD1 mRNA]
geraniol inhibits the reaction [Rotenone results in decreased activity of SOD1 protein]

PMID:22509279 PMID:30141137

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

Sod2

superoxide dismutase 2

multiple interactions

[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of SOD2 mRNA]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of SOD2 protein]
geraniol inhibits the reaction [Rotenone results in decreased activity of SOD2 protein]

PMID:22509279 PMID:30141137

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Sox9

SRY-box transcription factor 9

decreases expression

geraniol results in decreased expression of SOX9 mRNA

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

Sp100

SP100 nuclear antigen

increases expression

geraniol results in increased expression of SP100 mRNA

NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034

Sqstm1

sequestosome 1

increases expression
multiple interactions

geraniol results in increased expression of SQSTM1 mRNA
geraniol inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]

PMID:27683099 PMID:30141137

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

Srebf1

sterol regulatory element binding transcription factor 1

multiple interactions

geraniol promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

Srebf2

sterol regulatory element binding transcription factor 2

increases expression

geraniol results in increased expression of SREBF2 mRNA

PMID:23668785

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

Stat1

signal transducer and activator of transcription 1

increases expression

geraniol results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

Stat2

signal transducer and activator of transcription 2

increases expression

geraniol results in increased expression of STAT2 mRNA

NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967

Stat6

signal transducer and activator of transcription 6

increases expression

geraniol results in increased expression of STAT6 mRNA

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

Stmn1

stathmin 1

decreases expression

geraniol results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

Sub1

SUB1 regulator of transcription

decreases expression

geraniol results in decreased expression of SUB1 mRNA

NCBI chr 2:61,005,646...61,020,486
Ensembl chr 2:61,005,666...61,020,436
Ensembl chr 2:61,005,666...61,020,436

Supt16h

SPT16 homolog, facilitates chromatin remodeling subunit

decreases expression

geraniol results in decreased expression of SUPT16H mRNA

NCBI chr15:24,867,697...24,904,818
Ensembl chr15:24,866,489...24,904,846

Supt5h

SPT5 homolog, DSIF elongation factor subunit

increases expression

geraniol results in increased expression of SUPT5H mRNA

NCBI chr 1:83,586,713...83,616,971
Ensembl chr 1:83,586,718...83,616,892

Tardbp

TAR DNA binding protein

decreases expression

geraniol results in decreased expression of TARDBP mRNA

NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055

Tceal1

transcription elongation factor A like 1

increases expression

geraniol results in increased expression of TCEAL1 mRNA

NCBI chr X:100,058,485...100,060,439
Ensembl chr X:100,058,132...100,060,551

Tcf12

transcription factor 12

increases expression

geraniol results in increased expression of TCF12 mRNA

NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201

Tcf25

TCF25 ribosome quality control complex subunit

increases expression

geraniol results in increased expression of TCF25 mRNA

NCBI chr19:51,415,341...51,449,725
Ensembl chr19:51,415,543...51,449,723

Tcf4

transcription factor 4

decreases expression

geraniol results in decreased expression of TCF4 mRNA

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

Tcf7l2

transcription factor 7 like 2

decreases expression

geraniol results in decreased expression of TCF7L2 mRNA

NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967

Terf1

telomeric repeat binding factor 1

decreases expression

geraniol results in decreased expression of TERF1 mRNA

NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340

Tfap2a

transcription factor AP-2 alpha

increases expression

geraniol results in increased expression of TFAP2A mRNA

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

Tfcp2

transcription factor CP2

decreases expression

geraniol results in decreased expression of TFCP2 mRNA

NCBI chr 7:131,616,777...131,658,995
Ensembl chr 7:131,616,785...131,658,939

Tfdp1

transcription factor Dp-1

decreases expression

geraniol results in decreased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

Tgfb1

transforming growth factor, beta 1

multiple interactions

geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

Tgif1

TGFB-induced factor homeobox 1

increases expression

geraniol results in increased expression of TGIF1 mRNA

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

tyrosine hydroxylase

multiple interactions

geraniol inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

Timeless

timeless circadian regulator

decreases expression

geraniol results in decreased expression of TIMELESS mRNA

NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738

Tk1

thymidine kinase 1

decreases expression
multiple interactions

geraniol results in decreased expression of TK1 mRNA
Fluorouracil promotes the reaction [geraniol results in decreased expression of TK1 mRNA]

PMID:15374632

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

Tle1

TLE family member 1, transcriptional corepressor

increases expression

geraniol results in increased expression of TLE1 mRNA

NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774

Tlr4

toll-like receptor 4

multiple interactions

geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR4 mRNA]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR4 protein]

PMID:29050341

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

tumor necrosis factor

multiple interactions
increases expression

geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of and results in increased secretion of TNF protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of TNF protein]]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of TNF protein]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; geraniol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; geraniol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]
geraniol results in increased expression of TNF mRNA
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of TNF protein]; geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; geraniol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; geraniol inhibits the reaction [Fructose results in increased secretion of TNF protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of TNF protein]

PMID:21430599 PMID:23399806 PMID:25679220 PMID:26190278 PMID:26695085 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tp53

tumor protein p53

multiple interactions
increases expression

geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein]
geraniol results in increased expression of TP53 mRNA

PMID:21907755 PMID:27683099

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Tpx2

TPX2, microtubule nucleation factor

decreases expression

geraniol results in decreased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

Traip

TRAF-interacting protein

decreases expression

geraniol results in decreased expression of TRAIP mRNA

NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638

Trak1

trafficking kinesin protein 1

increases expression

geraniol results in increased expression of TRAK1 mRNA

NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367

Trim29

tripartite motif-containing 29

increases expression

geraniol results in increased expression of TRIM29 mRNA

NCBI chr 8:43,682,221...43,706,992
Ensembl chr 8:43,682,221...43,706,992

Trps1

transcriptional repressor GATA binding 1

increases expression

geraniol results in increased expression of TRPS1 mRNA

NCBI chr 7:81,916,668...82,142,733
Ensembl chr 7:81,921,601...82,141,905

Trpv1

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

geraniol binds to and results in increased activity of TRPV1 protein

PMID:20686244

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

Tsc22d3

TSC22 domain family, member 3

increases expression

geraniol results in increased expression of TSC22D3 mRNA

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

Ttk

Ttk protein kinase

decreases expression

geraniol results in decreased expression of TTK mRNA

NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651

Tulp3

TUB like protein 3

increases expression

geraniol results in increased expression of TULP3 mRNA

NCBI chr 4:161,590,478...161,632,244
Ensembl chr 4:161,590,479...161,632,149

Tulp4

TUB like protein 4

increases expression

geraniol results in increased expression of TULP4 mRNA

NCBI chr 1:46,682,416...46,813,167
Ensembl chr 1:46,682,863...46,809,688

Tyms

thymidylate synthetase

multiple interactions
decreases expression

Fluorouracil promotes the reaction [geraniol results in decreased expression of TYMS mRNA]

PMID:15374632

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

Ube2c

ubiquitin-conjugating enzyme E2C

decreases expression

geraniol results in decreased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

Ube2n

ubiquitin-conjugating enzyme E2N

decreases expression

geraniol results in decreased expression of UBE2N mRNA

NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355

Ubp1

upstream binding protein 1

decreases expression

geraniol results in decreased expression of UBP1 mRNA

NCBI chr 8:113,869,771...113,915,625
Ensembl chr 8:113,869,979...113,915,625

Ucp2

uncoupling protein 2

multiple interactions

geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of UCP2 protein]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

Vcam1

vascular cell adhesion molecule 1

multiple interactions

geraniol inhibits the reaction [Palmitic Acid results in increased expression of VCAM1 protein]
geraniol inhibits the reaction [Dietary Fats results in increased expression of VCAM1 protein]

PMID:27107694

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

Vegfa

vascular endothelial growth factor A

multiple interactions

geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of VEGFA protein]

PMID:26364502

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Vldlr

very low density lipoprotein receptor

increases expression

geraniol results in increased expression of VLDLR mRNA

PMID:26141755

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

Xbp1

X-box binding protein 1

increases expression

geraniol results in increased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

Zbtb1

zinc finger and BTB domain containing 1

increases expression

geraniol results in increased expression of ZBTB1 mRNA

NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996

Zbtb10

zinc finger and BTB domain containing 10

increases expression

geraniol results in increased expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

Zbtb11

zinc finger and BTB domain containing 11

decreases expression

geraniol results in decreased expression of ZBTB11 mRNA

NCBI chr11:44,598,694...44,652,559
Ensembl chr11:44,616,289...44,651,050

Zbtb20

zinc finger and BTB domain containing 20

increases expression

geraniol results in increased expression of ZBTB20 mRNA

NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210

Zfp110

zinc finger protein 110

increases expression

geraniol results in increased expression of ZNF274 mRNA

NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086

Zfp189

zinc finger protein 189

increases expression

geraniol results in increased expression of ZNF189 mRNA

NCBI chr 5:63,872,596...63,884,348
Ensembl chr 5:63,872,738...63,884,121

Zfp207

zinc finger protein 207

decreases expression

geraniol results in decreased expression of ZNF207 mRNA

NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386

Zfp248

zinc finger protein 248

decreases expression

geraniol results in decreased expression of ZNF248 mRNA

NCBI chr 4:151,605,433...151,630,249
Ensembl chr 4:151,606,495...151,629,850

Zfp263

zinc finger protein 263

increases expression

geraniol results in increased expression of ZNF263 mRNA

NCBI chr10:11,764,424...11,774,324
Ensembl chr10:11,764,427...11,771,235

Zfp281

zinc finger protein 281

increases expression

geraniol results in increased expression of ZNF281 mRNA

NCBI chr13:48,096,103...48,104,265
Ensembl chr13:48,037,286...48,104,888

Zfp329

zinc finger protein 329

increases expression

geraniol results in increased expression of ZNF329 mRNA

NCBI chr 1:73,403,067...73,498,349
Ensembl chr 1:73,402,972...73,422,037

Zfp334

zinc finger protein 334

increases expression

geraniol results in increased expression of ZNF334 mRNA

NCBI chr 3:154,112,537...154,125,087
Ensembl chr 3:154,113,561...154,125,057

Zfp354a

zinc finger protein 354A

increases expression

geraniol results in increased expression of ZNF354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068

Zfp394

zinc finger protein 394

increases expression

geraniol results in increased expression of ZNF394 mRNA

NCBI chr12:9,409,047...9,417,228
Ensembl chr12:9,409,078...9,417,246

Zfp410

zinc finger protein 410

increases expression

geraniol results in increased expression of ZNF410 mRNA

NCBI chr 6:103,963,265...103,990,252
Ensembl chr 6:103,964,060...103,990,225

Zfp455l1

zinc finger protein 455 like 1

increases expression

geraniol results in increased expression of KRBOX4 mRNA

NCBI chr 1:34,866,934...34,944,939
Ensembl chr 1:34,927,303...34,944,121

Zfp467

zinc finger protein 467

increases expression

geraniol results in increased expression of ZNF467 mRNA

NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229

Zfp606

zinc finger protein 606

increases expression

geraniol results in increased expression of ZNF606 mRNA

NCBI chr 1:72,981,920...73,022,423
Ensembl chr 1:72,981,989...73,008,072

Zfp612

zinc finger protein 612

increases expression

geraniol results in increased expression of ZNF23 mRNA

NCBI chr19:38,053,953...38,071,196
Ensembl chr19:38,053,967...38,067,455

Zfp68

zinc finger protein 68

increases expression

geraniol results in increased expression of ZNF84 mRNA

NCBI chr12:16,026,058...16,040,995
Ensembl chr12:16,026,079...16,040,995

Zfp75d

zinc finger protein 75D

increases expression

geraniol results in increased expression of ZNF75D mRNA

NCBI chr X:134,035,116...134,053,765
Ensembl chr X:134,036,143...134,051,519

Zfp768

zinc finger protein 768

increases expression

geraniol results in increased expression of ZNF768 mRNA

NCBI chr 1:181,966,314...181,968,950
Ensembl chr 1:181,966,316...181,969,147

Zhx2

zinc fingers and homeoboxes 2

increases expression

geraniol results in increased expression of ZHX2 mRNA

NCBI chr 7:89,226,358...89,374,266
Ensembl chr 7:89,226,463...89,374,378

Zmiz1

zinc finger, MIZ-type containing 1

increases expression

geraniol results in increased expression of ZMIZ1 mRNA

NCBI chr16:1,027,083...1,232,616
Ensembl chr16:1,027,325...1,232,597

Zmym4

zinc finger MYM-type containing 4

increases expression

geraniol results in increased expression of ZMYM4 mRNA

NCBI chr 5:139,146,782...139,264,387
Ensembl chr 5:139,146,665...139,264,421

Zmynd11

zinc finger, MYND-type containing 11

increases expression

geraniol results in increased expression of ZMYND11 mRNA

NCBI chr17:60,542,669...60,631,913
Ensembl chr17:60,543,077...60,631,902

Zscan18

zinc finger and SCAN domain containing 18

increases expression

geraniol results in increased expression of ZSCAN18 mRNA

NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897

Zzz3

zinc finger, ZZ-type containing 3

increases expression

geraniol results in increased expression of ZZZ3 mRNA

NCBI chr 2:241,330,366...241,397,308
Ensembl chr 2:241,331,022...241,397,307

geranyl acetate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bax

BCL2 associated X, apoptosis regulator

increases expression

geranyl acetate results in increased expression of BAX protein

PMID:29745075

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

decreases expression

geranyl acetate results in decreased expression of BCL2 protein

PMID:29745075

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

geranyl diphosphate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases abundance

[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]

PMID:19819230 PMID:19856009

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

mevalonate kinase

decreases activity
multiple interactions

geranyl diphosphate results in decreased activity of MVK protein
geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]

PMID:9392419

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Rap1a

RAP1A, member of RAS oncogene family

multiple interactions

[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form

PMID:19819230

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

geranylgeraniol

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akr1b10

aldo-keto reductase family 1 member B10

increases chemical synthesis

AKR1B10 protein results in increased chemical synthesis of geranylgeraniol

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

Akr1c3

aldo-keto reductase family 1, member C3

increases chemical synthesis

AKR1C3 protein results in increased chemical synthesis of geranylgeraniol

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

caspase 3

increases activity

geranylgeraniol results in increased activity of CASP3 protein

PMID:9175767

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cav1

caveolin 1

multiple interactions

geranylgeraniol inhibits the reaction [rosiglitazone results in increased expression of CAV1 mRNA]

PMID:15314095

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Ccn1

cellular communication network factor 1

multiple interactions

geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of CCN1 protein]

PMID:19530242

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

Egf

epidermal growth factor

multiple interactions

geranylgeraniol analog inhibits the reaction [EGF protein results in increased phosphorylation of RHOA protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

coagulation factor III, tissue factor

multiple interactions

geranylgeraniol inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]

PMID:9081680 PMID:12753293

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
decreases activity

[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein]

PMID:12477733 PMID:19819230

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

Ibsp

integrin-binding sialoprotein

multiple interactions

geranylgeraniol inhibits the reaction [zoledronic acid results in increased expression of IBSP mRNA]

PMID:15324309

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

interleukin 1 beta

multiple interactions

geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
geranylgeraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]

PMID:20304105

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Itga2

integrin subunit alpha 2

multiple interactions

geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]

PMID:12500026

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

Itgb1

integrin subunit beta 1

multiple interactions

PMID:12500026

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

mevalonate kinase

multiple interactions

[MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; geranylgeraniol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein]

PMID:12477733 PMID:20304105

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

Myl9

myosin light chain 9

multiple interactions

geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein]

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

Plat

plasminogen activator, tissue type

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT]

PMID:12371961 PMID:12753293

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

Ppara

peroxisome proliferator activated receptor alpha

multiple interactions

geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]

PMID:11779144

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

Ppp1r12a

protein phosphatase 1, regulatory subunit 12A

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]

PMID:24449418

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

Ppp1r14a

protein phosphatase 1, regulatory (inhibitor) subunit 14A

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]

PMID:24449418

NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671

Rac family small GTPase 1

multiple interactions

PMID:12933658 PMID:29777701

geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Geranylgeraniol inhibits the reaction [Ropivacaine decreases activity of RAC1 protein in esophageal carcinoma cells]

CTD
RGD

RGD:155230817

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

Rap1a

RAP1A, member of RAS oncogene family

multiple interactions

[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form; geranylgeraniol inhibits the reaction [zoledronic acid results in decreased geranoylation of RAP1A protein]

PMID:16539721 PMID:19819230

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

ras homolog family member A

multiple interactions

geranylgeraniol analog inhibits the reaction [EGF protein results in increased phosphorylation of RHOA protein]; geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of and affects the localization of RHOA protein]
geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]

PMID:9398081 PMID:12477733 PMID:12933658 PMID:15324309 PMID:24449418 More...

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Rhoc

ras homolog family member C

multiple interactions

geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein]

NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306

Rxra

retinoid X receptor alpha

multiple interactions

geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]

PMID:11779144

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

selectin E

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]

PMID:16740276

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

tumor necrosis factor

multiple interactions

geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]

PMID:16740276

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

solanesol

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

caspase 3

multiple interactions

2-phenylacetylenesulfonamide inhibits the reaction [solanesol inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]]; solanesol inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; solanesol promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]]; tin protoporphyrin IX inhibits the reaction [solanesol inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]]

PMID:25645596

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cat

catalase

multiple interactions

solanesol inhibits the reaction [Glucose results in decreased activity of CAT protein]

PMID:37586544

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Cul3

cullin 3

multiple interactions

solanesol inhibits the reaction [KEAP1 protein binds to CUL3 protein binds to RBX1 protein]

PMID:25645596

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

Gpt

glutamic--pyruvic transaminase

multiple interactions

solanesol inhibits the reaction [Glucose results in increased secretion of GPT protein]

PMID:37586544

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Hmox1

heme oxygenase 1

multiple interactions
increases expression

geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein]; solanesol inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]; solanesol inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]
solanesol results in increased expression of HMOX1 mRNA; solanesol results in increased expression of HMOX1 protein

PMID:25645596 PMID:37586544

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hsf1

heat shock transcription factor 1

multiple interactions
affects localization

2-phenylacetylenesulfonamide inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]
solanesol affects the localization of HSF1 protein

PMID:25645596

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

Keap1

Kelch-like ECH-associated protein 1

multiple interactions

solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA]; solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein]; solanesol inhibits the reaction [KEAP1 protein binds to CUL3 protein binds to RBX1 protein]; solanesol inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]

PMID:25645596 PMID:37586544

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

Nfe2l2

NFE2 like bZIP transcription factor 2

multiple interactions