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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amantadine
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Accession:CHEBI:2618 term browser browse the term
Definition:A member of the class of adamantanes that is used as an antiviral and antiparkinson drug.
Synonyms:exact_synonym: adamantan-1-ylamine
 related_synonym: 1-adamantanamine;   1-adamantylamine;   1-aminoadamantane;   Amantidine;   Aminoadamantane;   Formula=C10H17N;   InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2;   InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N;   SMILES=NC12CC3CC(CC(C3)C1)C2;   Viregyt;   Virosol;   amantadina;   amantadinum;   tricyclo[3.3.1.1(3,7)]decan-1-amine;   tricyclo[3.3.1.1(3,7)]decan-1-ylamine;   tricyclo[3.3.1.1(3,7)]decane-1-amine
 xref: CAS:768-94-5;   DrugBank:DB00915;   Drug_Central:144;   Gmelin:27066;   KEGG:C06818;   KEGG:D07441
 xref_mesh: MESH:D000547
 xref: PMID:23011311;   PMID:24371305;   PMID:24427376;   Reaxys:2204333;   VSDB:2961;   Wikipedia:Amantadine
 cyclic_relationship: is_conjugate_base_of CHEBI:48320


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amantadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA CTD PMID:19211973 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO Amantadine results in increased expression of IFI27 mRNA CTD PMID:16756086 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 affects expression ISO Amantadine affects the expression of IFNAR1 mRNA CTD PMID:16756086 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979 		JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Amantadine results in increased expression of JAK1 protein CTD PMID:16756086 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Amantadine results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression ISO Amantadine results in decreased expression of MAP2 mRNA CTD PMID:34748853 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 increases expression ISO Amantadine results in increased expression of OAS2 mRNA CTD PMID:16756086 NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Amantadine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amantadine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1 CTD PMID:15918519 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 decreases activity ISO Amantadine analog results in decreased activity of TDP1 protein CTD PMID:29248742 NCBI chr 6:119,163,192...119,231,029
Ensembl chr 6:119,163,166...119,231,021 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        pharmacological role 19080
          analgesic 14774
            amantadine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        primary amino compound 9347
                                          primary amine 6362
                                            primary aliphatic amine 191
                                              amantadine 11
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