|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization |
ISO |
neoxanthin affects the localization of AIFM1 protein |
CTD |
PMID:17186379 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:17186379 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
neoxanthin results in increased activity of CASP8 protein |
CTD |
PMID:17186379 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:17186379 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:33008094 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Alb |
albumin |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein] |
CTD |
PMID:34564187 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of ARG1 mRNA] |
CTD |
PMID:33008094 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
|
|
G |
Atg12 |
autophagy related 12 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG12 mRNA] |
CTD |
PMID:34439521 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
|
|
G |
Atg14 |
autophagy related 14 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG14 mRNA] |
CTD |
PMID:34439521 |
|
NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA] |
CTD |
PMID:33212048 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 mRNA]; astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 protein] |
CTD |
PMID:34439521 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
|
|
G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
astaxanthine results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA] |
CTD |
PMID:33212048 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA] astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein] |
CTD |
PMID:16964424 PMID:34564187 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Cntd1 |
cyclin N-terminal domain containing 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:86,221,430...86,231,812
|
|
G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein] |
CTD |
PMID:36084724 |
|
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
|
|
G |
Cox15 |
cytochrome c oxidase assembly homolog COX15 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
|
|
G |
Cox5a |
cytochrome c oxidase subunit 5A |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
|
|
G |
Cox5b |
cytochrome c oxidase subunit 5B |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
|
|
G |
Cox6b1 |
cytochrome c oxidase subunit 6B1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001 Ensembl chr 2:85,875,109...85,884,001
|
|
G |
Cox6c |
cytochrome c oxidase subunit 6C |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
|
|
G |
Ctss |
cathepsin S |
decreases expression |
ISO |
astaxanthine results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
|
|
G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions decreases expression |
EXP |
astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]] astaxanthine results in decreased expression of CYBB mRNA |
CTD |
PMID:23272707 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
EXP |
astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein astaxanthine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:21414371 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity multiple interactions |
EXP |
astaxanthine results in increased activity of G6PD protein [Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein |
CTD |
PMID:28665548 PMID:29975440 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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|
G |
Gfap |
glial fibrillary acidic protein |
decreases expression |
ISO |
astaxanthine results in decreased expression of GFAP mRNA |
CTD |
PMID:19555370 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
increases expression multiple interactions |
ISO |
astaxanthine results in increased expression of GJA1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein] |
CTD |
PMID:16091010 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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|
G |
Gna13 |
G protein subunit alpha 13 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein] |
CTD |
PMID:34564187 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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|
G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions increases expression |
EXP ISO |
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein] astaxanthine results in increased expression of GPX4 protein astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein] |
CTD |
PMID:36084724 PMID:37648051 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
|
|
G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
EXP |
[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] |
CTD |
PMID:23538867 |
|
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grn |
granulin precursor |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] |
CTD |
PMID:29975440 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions increases expression |
ISO |
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA astaxanthine results in increased expression of GSTM2 mRNA |
CTD |
PMID:24157545 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA] |
CTD |
PMID:16964424 PMID:34564187 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
astaxanthine results in increased expression of HMOX1 protein astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein] astaxanthine results in decreased expression of HMOX1 mRNA [astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]] astaxanthine results in increased expression of HMOX1 mRNA [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA] |
CTD |
PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hoxa9 |
homeobox A9 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358
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G |
Idh1 |
isocitrate dehydrogenase (NADP(+)) 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
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|
G |
Ifng |
interferon gamma |
increases expression |
ISO |
astaxanthine results in increased expression of IFNG protein |
CTD |
PMID:33132140 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of IL10 mRNA] astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein] |
CTD |
PMID:33008094 PMID:34564187 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il11 |
interleukin 11 |
increases expression |
ISO |
astaxanthine results in increased expression of IL11 protein |
CTD |
PMID:33132140 |
|
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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G |
Il1b |
interleukin 1 beta |
decreases expression multiple interactions |
ISO EXP |
astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of P53 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein] astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA] |
CTD |
PMID:21621527 PMID:33008094 PMID:34564187 PMID:36084724 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il6 |
interleukin 6 |
decreases expression multiple interactions |
ISO |
astaxanthine results in decreased expression of IL6 mRNA astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL6 mRNA] |
CTD |
PMID:21621527 PMID:33008094 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ins1 |
insulin 1 |
decreases expression |
ISO |
astaxanthine results in decreased expression of INS1 protein |
CTD |
PMID:33132140 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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|
G |
Lepr |
leptin receptor |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:34439521 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:34439521 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:33008094 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] |
CTD |
PMID:36084724 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
|
|
G |
Mt-nd6 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
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Ndufa1 |
NADH:ubiquinone oxidoreductase subunit A1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633
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Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
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Ndufc2 |
NADH:ubiquinone oxidoreductase subunit C2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
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Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions |
EXP ISO |
astaxanthine results in increased expression of NFE2L2 protein astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein] [astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]] astaxanthine results in increased expression of NFE2L2 mRNA [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA; astaxanthine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nme2 |
NME/NM23 nucleoside diphosphate kinase 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
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Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 protein] astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA] |
CTD |
PMID:33008094 PMID:34564187 PMID:36084724 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
EXP ISO |
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of NQO1 mRNA] astaxanthine results in increased expression of NQO1 mRNA astaxanthine results in increased expression of NQO1 protein |
CTD |
PMID:20038455 PMID:24157545 PMID:33212048 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Pah |
phenylalanine hydroxylase |
decreases expression |
ISO |
astaxanthine results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
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NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
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Pgd |
phosphogluconate dehydrogenase |
increases activity |
EXP |
astaxanthine results in increased activity of PGD protein |
CTD |
PMID:28665548 PMID:29975440 |
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NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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Por |
cytochrome p450 oxidoreductase |
decreases activity increases expression |
EXP |
astaxanthine results in decreased activity of POR protein astaxanthine results in increased expression of POR protein |
CTD |
PMID:21414371 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppp1cb |
protein phosphatase 1 catalytic subunit beta |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA] |
CTD |
PMID:33212048 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
astaxanthine results in decreased expression of PTGS2 mRNA astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21621527 PMID:33008094 PMID:36084724 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein] |
CTD |
PMID:34439521 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rps2 |
ribosomal protein S2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163
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Skap2 |
src kinase associated phosphoprotein 2 |
decreases expression |
ISO |
astaxanthine results in decreased expression of SKAP2 mRNA |
CTD |
PMID:19555370 |
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NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
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Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sp1 |
Sp1 transcription factor |
multiple interactions |
EXP |
[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] |
CTD |
PMID:23538867 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tgm2 |
transglutaminase 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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Tkt |
transketolase |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] |
CTD |
PMID:16964424 |
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NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Tlr2 |
toll-like receptor 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR2 mRNA] |
CTD |
PMID:33008094 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 mRNA] |
CTD |
PMID:33008094 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf |
tumor necrosis factor |
decreases expression multiple interactions increases expression |
ISO |
astaxanthine results in decreased expression of TNF protein astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA] astaxanthine results in increased expression of TNF protein |
CTD |
PMID:21621527 PMID:33008094 PMID:33132140 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] |
CTD |
PMID:20038455 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trem2 |
triggering receptor expressed on myeloid cells 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TREM2 mRNA] |
CTD |
PMID:33008094 |
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NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
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Ubb |
ubiquitin B |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] |
CTD |
PMID:16964424 |
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NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
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Uqcrb |
ubiquinol-cytochrome c reductase binding protein |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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Uqcrc2 |
ubiquinol cytochrome c reductase core protein 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] |
CTD |
PMID:16964424 |
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NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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Acad9 |
acyl-CoA dehydrogenase family, member 9 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
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Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
increases expression |
ISO |
beta Carotene results in increased expression of ADH5 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression |
ISO |
beta Carotene results in decreased expression of ADIPOQ mRNA |
CTD |
PMID:21569430 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Aebp1 |
AE binding protein 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877
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Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation decreases expression |
ISO |
beta Carotene results in decreased phosphorylation of AKT1 protein beta Carotene results in decreased expression of AKT1 mRNA |
CTD |
PMID:26733226 PMID:36819991 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alad |
aminolevulinate dehydratase |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein] |
CTD |
PMID:25542264 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Aldh3b1 |
aldehyde dehydrogenase 3 family, member B1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ALDH3B1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
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Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ALDH4A1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
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Ank2 |
ankyrin 2 |
increases expression |
ISO |
beta Carotene results in increased expression of ANK2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
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Ank3 |
ankyrin 3 |
increases expression |
ISO |
beta Carotene results in increased expression of ANK3 mRNA |
CTD |
PMID:17034753 |
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NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Appbp2 |
amyloid beta precursor protein binding protein 2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA |
CTD |
PMID:24657404 |
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NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835
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Arhgap26 |
Rho GTPase activating protein 26 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA |
CTD |
PMID:24657404 |
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NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194
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Asah1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO |
beta Carotene results in increased expression of ASAH1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asb1 |
ankyrin repeat and SOCS box-containing 1 |
increases expression |
ISO |
beta Carotene results in increased expression of ASB1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376
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Asb9 |
ankyrin repeat and SOCS box-containing 9 |
increases expression |
ISO |
beta Carotene results in increased expression of ASB9 mRNA |
CTD |
PMID:17034753 |
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NCBI chr X:29,956,576...30,001,436
Ensembl chr X:29,956,576...30,001,105
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Atp8b1 |
ATPase phospholipid transporting 8B1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Bag3 |
BAG cochaperone 3 |
decreases expression |
ISO |
beta Carotene results in decreased expression of BAG3 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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Bag4 |
BAG cochaperone 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of BAG4 mRNA |
CTD |
PMID:17034753 |
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NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
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G |
Bag5 |
BAG cochaperone 5 |
decreases expression |
ISO |
beta Carotene results in decreased expression of BAG5 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression increases expression |
ISO |
beta Carotene results in decreased expression of BAX mRNA beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein |
CTD |
PMID:15949688 PMID:17034753 PMID:26733226 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
beta Carotene results in decreased expression of BCL2 protein |
CTD |
PMID:26733226 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bco1 |
beta-carotene oxygenase 1 |
multiple interactions affects response to substance increases oxidation increases expression |
ISO EXP |
beta Carotene results in increased expression of and results in increased activity of BCO1 protein [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA BCO1 protein results in increased oxidation of beta Carotene beta Carotene results in increased expression of BCO1 mRNA Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]] |
CTD |
PMID:9526112 PMID:16186334 PMID:24657404 |
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NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101
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G |
Bco2 |
beta-carotene oxygenase 2 |
multiple interactions increases metabolic processing |
ISO |
[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal |
CTD |
PMID:21106934 |
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NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein] beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein |
CTD |
PMID:17618090 PMID:26733226 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein] beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein] |
CTD |
PMID:9306888 PMID:12500499 PMID:25542264 PMID:31022331 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of CAV1 protein |
CTD |
PMID:26733226 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of CCND1 protein |
CTD |
PMID:26733226 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdca8 |
cell division cycle associated 8 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein |
CTD |
PMID:17034753 PMID:26733226 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
beta Carotene results in decreased expression of CEBPA mRNA |
CTD |
PMID:21569430 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cenpe |
centromere protein E |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA |
CTD |
PMID:24657404 |
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NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
ISO |
beta Carotene results in increased expression of CFLAR mRNA |
CTD |
PMID:17034753 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Clcn3 |
chloride voltage-gated channel 3 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA |
CTD |
PMID:24657404 |
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NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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G |
Cldn10 |
claudin 10 |
increases expression |
ISO |
beta Carotene results in increased expression of CLDN10 mRNA |
CTD |
PMID:17034753 |
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NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526
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G |
Cldn18 |
claudin 18 |
increases expression |
ISO |
beta Carotene results in increased expression of CLDN18 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
beta Carotene results in decreased expression of COL1A1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col4a1 |
collagen type IV alpha 1 chain |
decreases expression |
ISO |
beta Carotene results in decreased expression of COL4A1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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G |
Col4a2 |
collagen type IV alpha 2 chain |
decreases expression |
ISO |
beta Carotene results in decreased expression of COL4A2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
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G |
Coq7 |
coenzyme Q7, hydroxylase |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
decreases expression |
ISO |
beta Carotene results in decreased expression of CPT1B mRNA |
CTD |
PMID:21569430 |
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NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cradd |
CASP2 and RIPK1 domain containing adaptor with death domain |
increases expression |
ISO |
beta Carotene results in increased expression of CRADD mRNA |
CTD |
PMID:17034753 |
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NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907
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G |
Ctnnal1 |
catenin alpha-like 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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G |
Ctsb |
cathepsin B |
decreases expression |
ISO |
beta Carotene results in decreased expression of CTSB mRNA |
CTD |
PMID:17034753 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCL12 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCL6 mRNA |
CTD |
PMID:17034753 |
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NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCL9 mRNA |
CTD |
PMID:17034753 |
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NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCR4 mRNA |
CTD |
PMID:17034753 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]] |
CTD |
PMID:16970932 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
increases expression |
ISO |
beta Carotene results in increased expression of CYP26A1 mRNA |
CTD |
PMID:16186334 PMID:22542753 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp3a18 |
cytochrome P450, family 3, subfamily a, polypeptide 18 |
increases expression |
ISO |
beta Carotene results in increased expression of CYP3A43 mRNA |
CTD |
PMID:17034753 |
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NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dhfr |
dihydrofolate reductase |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA |
CTD |
PMID:24657404 |
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NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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G |
Dlx2 |
distal-less homeobox 2 |
increases expression |
ISO |
beta Carotene results in increased expression of DLX2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597
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G |
Dlx4 |
distal-less homeobox 4 |
increases expression |
ISO |
beta Carotene results in increased expression of DLX4 mRNA |
CTD |
PMID:17034753 |
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NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
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G |
Dpp4 |
dipeptidylpeptidase 4 |
multiple interactions |
ISO |
[Xiao-Ke-An results in increased abundance of beta Carotene] which results in decreased activity of DPP4 protein |
CTD |
PMID:32535096 |
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NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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G |
Dtwd2 |
DTW domain containing 2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA |
CTD |
PMID:24657404 |
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NCBI chr18:42,811,783...42,902,040
Ensembl chr18:42,816,681...42,901,832
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Ercc2 |
ERCC excision repair 2, TFIIH core complex helicase subunit |
decreases expression |
ISO |
beta Carotene results in decreased expression of ERCC2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] |
CTD |
PMID:17051425 PMID:19340624 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] |
CTD |
PMID:17051425 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of FABP4 mRNA |
CTD |
PMID:21569430 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Faim2 |
Fas apoptotic inhibitory molecule 2 |
increases expression |
ISO |
beta Carotene results in increased expression of FAIM2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
beta Carotene results in increased expression of FAS mRNA |
CTD |
PMID:17034753 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
beta Carotene results in increased expression of FOSL1 protein |
CTD |
PMID:20025956 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Foxa1 |
forkhead box A1 |
increases expression |
ISO |
beta Carotene results in increased expression of FOXA1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G |
Foxm1 |
forkhead box M1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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G |
Fzd6 |
frizzled class receptor 6 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776
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G |
Gata6 |
GATA binding protein 6 |
increases expression |
ISO |
beta Carotene results in increased expression of GATA6 mRNA |
CTD |
PMID:17034753 |
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NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
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G |
Gbp1 |
guanylate binding protein 1 |
increases expression |
ISO |
beta Carotene results in increased expression of GBP1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions increases expression |
ISO EXP |
beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein] beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein] |
CTD |
PMID:16091010 PMID:27154496 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein] |
CTD |
PMID:25542264 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of GSTK1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
ISO |
beta Carotene results in increased expression of GSTM2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm4 |
glutathione S-transferase mu 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of GSTM4 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstm5l |
glutathione S-transferase, mu 5-like |
increases expression |
ISO |
beta Carotene results in increased expression of GSTM5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of GSTZ1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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G |
Hoxa7 |
homeobox A7 |
increases expression |
ISO |
beta Carotene results in increased expression of HOXA7 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659
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G |
Hoxb6 |
homeo box B6 |
increases expression |
ISO |
beta Carotene results in increased expression of HOXB6 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449
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G |
Hoxc10 |
homeo box C10 |
increases expression |
ISO |
beta Carotene results in increased expression of HOXC10 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
multiple interactions |
EXP |
beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene] |
CTD |
PMID:12467141 |
|
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA |
CTD |
PMID:23859036 |
|
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] |
CTD |
PMID:21447443 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Irf8 |
interferon regulatory factor 8 |
increases expression |
ISO |
beta Carotene results in increased expression of IRF8 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
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G |
Irx4 |
iroquois homeobox 4 |
decreases expression multiple interactions |
ISO |
beta Carotene results in decreased expression of IRX4 mRNA [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA |
CTD |
PMID:17034753 PMID:24657404 |
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NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
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G |
Itgb1 |
integrin subunit beta 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ITGB1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb4 |
integrin subunit beta 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ITGB4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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G |
Itm2a |
integral membrane protein 2A |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA |
CTD |
PMID:24657404 |
|
NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
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G |
Ivl |
involucrin |
increases expression |
ISO |
beta Carotene results in increased expression of IVL mRNA |
CTD |
PMID:17034753 |
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NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
beta Carotene results in increased expression of JUN protein |
CTD |
PMID:20025956 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kif11 |
kinesin family member 11 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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G |
Krt18 |
keratin 18 |
increases expression |
ISO |
beta Carotene results in increased expression of KRT18 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Krt19 |
keratin 19 |
increases expression |
ISO |
beta Carotene results in increased expression of KRT19 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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G |
Krt2 |
keratin 2 |
increases expression |
ISO |
beta Carotene results in increased expression of KRT2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963
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G |
Krt7 |
keratin 7 |
affects expression |
ISO |
beta Carotene affects the expression of KRT7 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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G |
Krt8 |
keratin 8 |
decreases expression |
ISO |
beta Carotene results in decreased expression of KRT8 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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G |
Lancl1 |
LanC like glutathione S-transferase 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 9:68,515,052...68,548,646
Ensembl chr 9:68,518,574...68,548,628
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G |
Lhx3 |
LIM homeobox 3 |
increases expression |
ISO |
beta Carotene results in increased expression of LHX3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480
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G |
Lmnb2 |
lamin B2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665
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G |
LOC100912356 |
interferon alpha-1-like |
increases expression |
ISO |
beta Carotene results in increased expression of IFNA5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 5:103,227,820...103,230,500
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G |
Lpl |
lipoprotein lipase |
decreases expression |
ISO |
beta Carotene results in decreased expression of LPL mRNA |
CTD |
PMID:21569430 |
|
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO EXP |
beta Carotene results in increased phosphorylation of MAPK1 protein beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:16206275 PMID:27154496 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO EXP |
beta Carotene results in increased phosphorylation of MAPK3 protein beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:16206275 PMID:27154496 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mbl2 |
mannose binding lectin 2 |
multiple interactions |
ISO |
MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] |
CTD |
PMID:16960176 |
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NCBI chr 1:228,016,439...228,024,736
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
affects expression |
ISO |
beta Carotene affects the expression of MCL1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Meis2 |
Meis homeobox 2 |
increases expression |
ISO |
beta Carotene results in increased expression of MEIS2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696
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G |
Meox1 |
mesenchyme homeobox 1 |
increases expression |
ISO |
beta Carotene results in increased expression of MEOX1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
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G |
Mettl21a |
methyltransferase 21A, HSPA lysine |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550
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G |
Mettl9 |
methyltransferase 9, His-X-His N1(pi)-histidine |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:175,575,805...175,623,065
Ensembl chr 1:175,577,890...175,623,061
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
affects response to substance |
ISO |
MGMT gene SNP affects the susceptibility to beta Carotene |
CTD |
PMID:16014702 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA |
CTD |
PMID:23859036 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mnx1 |
motor neuron and pancreas homeobox 1 |
increases expression |
ISO |
beta Carotene results in increased expression of MNX1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 4:5,866,506...5,871,465
Ensembl chr 4:5,866,506...5,871,465
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] |
CTD |
PMID:31022331 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrpl57 |
mitochondrial ribosomal protein L57 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr15:31,970,904...31,971,766
Ensembl chr15:31,970,860...31,973,993
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G |
Msh5 |
mutS homolog 5 |
increases expression |
ISO |
beta Carotene results in increased expression of MSH5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336
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G |
Mtch2 |
mitochondrial carrier 2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
increases expression |
ISO |
beta Carotene results in increased expression of MUC5AC mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Nckap1 |
NCK-associated protein 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
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G |
Nom1 |
nucleolar protein with MIF4G domain 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 4:5,891,220...5,910,741
Ensembl chr 4:5,892,909...5,909,709
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G |
Nos1 |
nitric oxide synthase 1 |
increases expression |
ISO |
beta Carotene results in increased expression of NOS1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA] |
CTD |
PMID:18779489 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] beta Carotene results in increased activity of NR1I2 protein |
CTD |
PMID:15949683 PMID:16632523 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
increases expression |
ISO |
beta Carotene results in increased expression of OLR1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Pard6a |
par-6 family cell polarity regulator alpha |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA |
CTD |
PMID:24657404 |
|
NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900
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G |
Pcdh1 |
protocadherin 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr18:30,011,692...30,039,679
Ensembl chr18:30,013,185...30,039,318
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G |
Pcdhgc3 |
protocadherin gamma subfamily C, 3 |
increases expression |
ISO |
beta Carotene results in increased expression of PCDHGC3 mRNA |
CTD |
PMID:17034753 |
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NCBI chr18:29,633,016...29,667,865
Ensembl chr18:29,493,954...29,667,868
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein |
CTD |
PMID:23859036 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Pik3r5 |
phosphoinositide-3-kinase, regulatory subunit 5 |
increases expression |
ISO |
beta Carotene results in increased expression of PIK3R5 protein |
CTD |
PMID:20025956 |
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NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA |
CTD |
PMID:24657404 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Plscr1 |
phospholipid scramblase 1 |
increases expression |
ISO |
beta Carotene results in increased expression of PLSCR1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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G |
Plscr3 |
phospholipid scramblase 3 |
increases expression |
ISO |
beta Carotene results in increased expression of PLSCR3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709
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G |
Plscr4 |
phospholipid scramblase 4 |
increases expression |
ISO |
beta Carotene results in increased expression of PLSCR4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression |
ISO |
beta Carotene results in decreased expression of PPARA mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
beta Carotene results in decreased expression of PPARG mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Rad51ap1 |
RAD51 associated protein 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of RAD51AP1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524
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G |
Rad51d |
RAD51 paralog D |
increases expression |
ISO |
beta Carotene results in increased expression of RAD51D mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434
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G |
Rara |
retinoic acid receptor, alpha |
decreases expression |
ISO |
beta Carotene results in decreased expression of RARA mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rarb |
retinoic acid receptor, beta |
increases expression |
ISO |
beta Carotene results in increased expression of RARB mRNA |
CTD |
PMID:17034753 |
|
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarres1 |
retinoic acid receptor responder 1 |
increases expression |
ISO |
beta Carotene results in increased expression of RARRES1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
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G |
Rbp4 |
retinol binding protein 4 |
multiple interactions |
ISO |
beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein |
CTD |
PMID:22542753 |
|
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases phosphorylation |
ISO |
beta Carotene results in decreased phosphorylation of RELA protein |
CTD |
PMID:26733226 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rpp14 |
ribonuclease P/MRP subunit p14 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr15:16,837,796...16,847,970
Ensembl chr15:16,836,859...16,852,101 Ensembl chr15:16,836,859...16,852,101
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G |
Rrm1 |
ribonucleotide reductase catalytic subunit M1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Scarb1 |
scavenger receptor class B, member 1 |
increases transport |
ISO |
SCARB1 protein results in increased transport of beta Carotene |
CTD |
PMID:16177187 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Six6 |
SIX homeobox 6 |
increases expression |
ISO |
beta Carotene results in increased expression of SIX6 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:91,634,568...91,639,548
Ensembl chr 6:91,634,568...91,639,548
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G |
Slc2a4 |
solute carrier family 2 member 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of SLC2A4 mRNA |
CTD |
PMID:21569430 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of SOD1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] |
CTD |
PMID:18779489 PMID:23859036 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sptlc2 |
serine palmitoyltransferase, long chain base subunit 2 |
affects expression |
ISO |
beta Carotene affects the expression of SPTLC2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
ISO |
beta Carotene results in increased expression of SREBF1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tfcp2 |
transcription factor CP2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 7:131,616,777...131,658,995
Ensembl chr 7:131,616,785...131,658,939
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G |
Tgm2 |
transglutaminase 2 |
increases expression |
ISO |
beta Carotene results in increased expression of TGM2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Tgm4 |
transglutaminase 4 |
increases expression |
ISO |
beta Carotene results in increased expression of TGM4 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 8:122,689,429...122,726,463
Ensembl chr 8:122,689,429...122,726,463
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G |
Thoc7 |
THO complex subunit 7 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA |
CTD |
PMID:24657404 |
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NCBI chr15:11,262,362...11,277,200
Ensembl chr15:11,262,613...11,277,193
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G |
Tmem209 |
transmembrane protein 209 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 4:59,102,943...59,128,636
Ensembl chr 4:59,101,550...59,128,630
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]] beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:19135038 PMID:21447443 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
increases expression |
ISO |
beta Carotene results in increased expression of TNFRSF9 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
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G |
Tnfsf10 |
TNF superfamily member 10 |
increases expression |
ISO |
beta Carotene results in increased expression of TNFSF10 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Ttc21b |
tetratricopeptide repeat domain 21B |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA |
CTD |
PMID:24657404 |
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NCBI chr 3:50,861,367...50,935,880
Ensembl chr 3:50,861,367...50,935,903
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G |
Twf1 |
twinfilin actin-binding protein 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894
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G |
Txndc9 |
thioredoxin domain containing 9 |
increases expression |
ISO |
beta Carotene results in increased expression of TXNDC9 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 9:40,211,818...40,221,953
Ensembl chr 9:40,211,412...40,384,279 Ensembl chr 9:40,211,412...40,384,279
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G |
Tymp |
thymidine phosphorylase |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA |
CTD |
PMID:24657404 |
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NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
beta Carotene results in decreased expression of VEGFA mRNA |
CTD |
PMID:36819991 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Xrcc3 |
X-ray repair cross complementing 3 |
increases expression |
ISO |
beta Carotene results in increased expression of XRCC3 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
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G |
Ythdc2 |
YTH N6-methyladenosine RNA binding protein C2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA |
CTD |
PMID:24657404 |
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NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023
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G |
Zdhhc3 |
zinc finger DHHC-type palmitoyltransferase 3 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 8:122,725,206...122,773,542
Ensembl chr 8:122,715,111...122,773,529
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases ubiquitination |
ISO |
bixin results in decreased ubiquitination of NFE2L2 protein |
CTD |
PMID:30698894 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein |
CTD |
PMID:23948132 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
ISO |
brazilein results in decreased expression of CTNNB1 protein |
CTD |
PMID:23948132 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
ISO |
brazilein results in decreased expression of GSK3B protein modified form |
CTD |
PMID:23948132 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein] brazilein results in decreased expression of MMP2 mRNA |
CTD |
PMID:23707804 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:23707804 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
brazilein results in decreased expression of RELA protein |
CTD |
PMID:23707804 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
brazilin results in increased expression of BAX protein |
CTD |
PMID:28063998 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
brazilin results in decreased expression of BCL2 protein |
CTD |
PMID:28063998 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein |
CTD |
PMID:28063998 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
brazilin results in increased activity of CASP3 protein Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] |
CTD |
PMID:28063998 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression |
ISO |
bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form] |
CTD |
PMID:28063998 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] |
CTD |
PMID:28063998 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sqstm1 |
sequestosome 1 |
decreases expression multiple interactions |
ISO |
brazilin results in decreased expression of SQSTM1 protein Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein] |
CTD |
PMID:28063998 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO EXP |
Canthaxanthin results in increased expression of CYP1A1 mRNA |
CTD |
PMID:9271336 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP ISO |
Canthaxanthin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:9271336 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
A4galt |
alpha 1,4-galactosyltransferase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] |
CTD |
PMID:16819191 |
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NCBI chr 7:114,368,525...114,392,872
Ensembl chr 7:114,368,276...114,396,071
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of AARS1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]] |
CTD |
PMID:33952798 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects response to substance decreases response to substance decreases expression multiple interactions |
ISO |
ABCB1 affects the susceptibility to Curcumin ABCB1 protein results in decreased susceptibility to Curcumin Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA] [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein |
CTD |
PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 PMID:18439772 PMID:20816778 PMID:26689174 PMID:27318188 PMID:31628941 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA] Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein |
CTD |
PMID:18006147 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity decreases expression |
ISO |
Curcumin results in decreased activity of ABCC1 protein Curcumin analog results in decreased expression of ABCC1 mRNA |
CTD |
PMID:15885658 PMID:16021489 PMID:26409325 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions |
ISO |
Curcumin results in decreased activity of ABCC2 protein [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein |
CTD |
PMID:15885658 PMID:35243748 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein |
CTD |
PMID:35243748 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] |
CTD |
PMID:23978416 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
Curcumin results in increased expression of ABCG1 mRNA |
CTD |
PMID:16713233 PMID:21594647 |
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NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions decreases expression increases expression |
ISO |
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] Curcumin results in decreased expression of ABCG2 mRNA |
CTD |
PMID:17077187 PMID:33539684 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation decreases expression affects expression multiple interactions |
ISO EXP |
Curcumin results in increased phosphorylation of ACACA protein Curcumin results in decreased expression of ACACA mRNA Curcumin affects the expression of ACACA mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein] |
CTD |
PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB protein] |
CTD |
PMID:37701206 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] |
CTD |
PMID:10666014 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions affects binding |
EXP ISO |
Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein] Curcumin binds to ACE2 protein |
CTD |
PMID:26648693 PMID:34138966 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO EXP |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein] Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein] Curcumin results in decreased activity of ACHE protein Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]] |
CTD |
PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 PMID:25496357 PMID:28527659 PMID:31714633 PMID:31820278 PMID:36924976 More...
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ackr3 |
atypical chemokine receptor 3 |
increases expression |
ISO |
Curcumin results in increased expression of ACKR3 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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G |
Acly |
ATP citrate lyase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of ACLY mRNA Curcumin results in decreased expression of ACLY mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Aco2 |
aconitase 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] |
CTD |
PMID:25130536 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP ISO |
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 PMID:31612257 PMID:32718261 PMID:35716765 More...
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] |
CTD |
PMID:17666914 |
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NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Adamts4 |
ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
increases expression |
ISO |
Curcumin results in increased expression of ADAMTS4 mRNA |
CTD |
PMID:18321735 |
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NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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G |
Adcy9 |
adenylate cyclase 9 |
decreases expression |
ISO |
Curcumin results in decreased expression of ADCY9 mRNA |
CTD |
PMID:15713895 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ADGRE1 mRNA |
CTD |
PMID:18403477 |
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NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression multiple interactions affects expression |
ISO EXP |
Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]] Curcumin affects the expression of ADIPOQ mRNA Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] |
CTD |
PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adora2a |
adenosine A2a receptor |
multiple interactions |
ISO |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] |
CTD |
PMID:31820278 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] |
CTD |
PMID:29480285 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Agr2 |
anterior gradient 2, protein disulphide isomerase family member |
decreases expression |
ISO |
Curcumin results in decreased expression of AGR2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP ISO |
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein] |
CTD |
PMID:26612707 PMID:26648693 PMID:31820278 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr2 |
angiotensin II receptor, type 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein] |
CTD |
PMID:26648693 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects binding increases degradation |
ISO |
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] Curcumin binds to AHR protein Curcumin results in increased degradation of AHR protein [Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] |
CTD |
PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak1 |
adenylate kinase 1 |
multiple interactions |
ISO |
[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein |
CTD |
PMID:25866362 |
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NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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G |
Akap6 |
A-kinase anchoring protein 6 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of AKAP6 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA] |
CTD |
PMID:18200517 PMID:18421014 |
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NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression multiple interactions increases activity |
ISO EXP |
Curcumin results in increased expression of AKR1B1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein Curcumin results in increased activity of AKR1B1 protein |
CTD |
PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions affects phosphorylation decreases expression decreases phosphorylation increases expression increases phosphorylation decreases activity |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] Curcumin affects the phosphorylation of AKT1 protein Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein Curcumin results in increased expression of AKT1 protein AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] Curcumin results in decreased activity of AKT1 protein |
CTD |
PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 PMID:17372590 PMID:17535857 PMID:17596214 PMID:17640564 PMID:17640567 PMID:17918158 PMID:18006147 PMID:18214481 PMID:18660423 PMID:18790744 PMID:19372569 PMID:20605902 PMID:20727180 PMID:20938987 PMID:23222814 PMID:23452621 PMID:23555722 PMID:24211270 PMID:24365254 PMID:24831732 PMID:25541178 PMID:26409325 PMID:27208389 PMID:27966075 PMID:34577062 PMID:34634291 PMID:35752269 PMID:36640941 PMID:37471645 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions decreases phosphorylation decreases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein] Curcumin analog results in decreased expression of AKT2 mRNA |
CTD |
PMID:23452621 PMID:26409325 PMID:36640941 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Akt3 |
AKT serine/threonine kinase 3 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein] Curcumin results in decreased expression of AKT3 protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein] |
CTD |
PMID:36640941 PMID:37471645 |
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NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP ISO |
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein] Curcumin inhibits the reaction [Bortezomib results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein] |
CTD |
PMID:22704994 PMID:23292317 PMID:25352650 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Curcumin results in increased expression of ALAS1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Alb |
albumin |
multiple interactions |
EXP |
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]] |
CTD |
PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 PMID:32718261 More...
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alcam |
activated leukocyte cell adhesion molecule |
decreases expression |
ISO |
Curcumin results in decreased expression of ALCAM mRNA |
CTD |
PMID:33539684 |
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NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions decreases expression |
ISO |
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA] [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein] Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein |
CTD |
PMID:31628941 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
decreases expression |
ISO |
Curcumin results in decreased expression of ALDOA mRNA |
CTD |
PMID:16880289 |
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NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
Curcumin results in decreased expression of ALDOC mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions decreases activity |
EXP |
[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein Curcumin results in decreased activity of ALOX5 protein |
CTD |
PMID:16956363 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Amfr |
autocrine motility factor receptor |
increases expression |
ISO |
Curcumin results in increased expression of AMFR mRNA; Curcumin results in increased expression of AMFR protein |
CTD |
PMID:38229314 |
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NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
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G |
Ampd1 |
adenosine monophosphate deaminase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein] |
CTD |
PMID:36924976 |
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NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938
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G |
Ampd3 |
adenosine monophosphate deaminase 3 |
increases expression |
EXP |
Curcumin results in increased expression of AMPD3 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
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G |
Ankrd37 |
ankyrin repeat domain 37 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKRD37 mRNA |
CTD |
PMID:17198877 |
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NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
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G |
Ankrd50 |
ankyrin repeat domain containing 50 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKRD50 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 2:121,466,275...121,500,758
Ensembl chr 2:121,468,573...121,500,752
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G |
Ankzf1 |
ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKZF1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein] |
CTD |
PMID:20885979 PMID:35817260 |
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NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of APAF1 protein Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] |
CTD |
PMID:17277231 PMID:20869986 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apc |
APC regulator of WNT signaling pathway |
decreases expression |
ISO |
Curcumin results in decreased expression of APC mRNA |
CTD |
PMID:15713895 |
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NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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G |
Apoe |
apolipoprotein E |
affects expression |
ISO |
Curcumin affects the expression of APOE mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions increases expression |
ISO EXP |
Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein] Curcumin results in increased expression of APP mRNA [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] |
CTD |
PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of AQP3 protein Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein] |
CTD |
PMID:18214481 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Aqp9 |
aquaporin 9 |
increases expression |
ISO |
Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 protein |
CTD |
PMID:34675983 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Ar |
androgen receptor |
multiple interactions increases expression decreases activity decreases expression |
ISO |
[[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein] Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein Curcumin results in decreased activity of AR protein Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein |
CTD |
PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgap24 |
Rho GTPase activating protein 24 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823
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G |
Arhgap30 |
Rho GTPase activating protein 30 |
decreases expression |
ISO |
Curcumin results in decreased expression of ARHGAP30 mRNA |
CTD |
PMID:18421014 |
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NCBI chr13:83,822,290...83,843,634
Ensembl chr13:83,822,283...83,854,885
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G |
Arhgdib |
Rho GDP dissociation inhibitor beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions increases degradation decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] Curcumin results in decreased expression of ARNT protein |
CTD |
PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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G |
Atf2 |
activating transcription factor 2 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of ATF2 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein |
CTD |
PMID:15713895 PMID:18555241 PMID:18719366 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions decreases expression |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein] ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein] |
CTD |
PMID:36640941 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
Curcumin results in increased expression of ATF6 protein Curcumin results in increased expression of ATF6 mRNA |
CTD |
PMID:21793155 PMID:29723631 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg4b |
autophagy related 4B, cysteine peptidase |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of ATG4B protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein] |
CTD |
PMID:36640941 |
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NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
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G |
Atg5 |
autophagy related 5 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of ATG5 protein Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein] |
CTD |
PMID:36640941 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions increases phosphorylation |
ISO |
[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein Curcumin results in increased phosphorylation of ATM protein |
CTD |
PMID:19401701 PMID:21134073 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Aurka |
aurora kinase A |
decreases expression |
ISO |
Curcumin analog results in decreased expression of AURKA mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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G |
Aurkb |
aurora kinase B |
decreases expression |
ISO |
Curcumin analog results in decreased expression of AURKB mRNA |
CTD |
PMID:26409325 |
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NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Axin1 |
axin 1 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA] Curcumin results in increased expression of AXIN1 mRNA |
CTD |
PMID:25963729 |
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NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615
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G |
B3galt6 |
Beta-1,3-galactosyltransferase 6 |
increases expression |
ISO |
Curcumin results in increased expression of B3GALT6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338
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G |
Bace1 |
beta-secretase 1 |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA] Curcumin results in increased expression of BACE1 mRNA |
CTD |
PMID:18583042 PMID:31521693 |
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NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein [arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein] |
CTD |
PMID:15569404 PMID:19235267 PMID:27430728 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions decreases expression increases expression increases response to substance |
ISO |
TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein] Curcumin results in decreased expression of BAK1 mRNA Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein BAK1 protein results in increased susceptibility to Curcumin |
CTD |
PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions affects expression decreases expression increases expression affects localization increases response to substance |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein] Curcumin affects the expression of BAX protein Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] BAX protein results in increased susceptibility to Curcumin [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein] |
CTD |
PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 PMID:17671742 PMID:18226269 PMID:19235267 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:23222814 PMID:23267840 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:27793699 PMID:27966075 PMID:28681665 PMID:30463061 PMID:30935902 PMID:31628941 PMID:33582110 PMID:34577062 PMID:35817260 PMID:36037877 PMID:36178099 PMID:36305173 PMID:36352148 PMID:38056816 PMID:38348716 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of BBC3 mRNA Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein] Curcumin results in decreased expression of BBC3 mRNA |
CTD |
PMID:17332930 PMID:22714040 PMID:34047412 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl10 |
BCL10, immune signaling adaptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein] Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein] 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein] |
CTD |
PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 PMID:16243823 PMID:17096185 PMID:17332930 PMID:17440100 PMID:17531121 PMID:17596214 PMID:17640567 PMID:17671737 PMID:17671742 PMID:18226269 PMID:18593936 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:19373661 PMID:19944674 PMID:20127174 PMID:20727180 PMID:20869986 PMID:21397623 PMID:21594647 PMID:21595920 PMID:21793155 PMID:22714040 PMID:23452621 PMID:24952339 PMID:25256401 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:28681665 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30935902 PMID:31628941 PMID:32569592 PMID:33582110 PMID:33617879 PMID:34577062 PMID:34675983 PMID:34758851 PMID:35817260 PMID:36037877 PMID:36178099 PMID:36305173 PMID:36352148 PMID:38056816 PMID:38348716 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] Curcumin results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:16219905 PMID:17596214 |
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NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein] Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein] [Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein Curcumin results in increased expression of BCL2L1 mRNA |
CTD |
PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:17148446 PMID:17332930 PMID:17440100 PMID:17596214 PMID:17640567 PMID:17671737 PMID:18226269 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:23452621 PMID:30463061 More...
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BCL2L11 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein |
CTD |
PMID:17332930 PMID:27430728 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bcl2l2 |
Bcl2-like 2 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BCL2L2 mRNA [arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein |
CTD |
PMID:16101141 PMID:27430728 |
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NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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G |
Bcl3 |
BCL3, transcription coactivator |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA] |
CTD |
PMID:18200517 PMID:23452621 |
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NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bcor |
BCL6 co-repressor |
increases expression |
ISO |
Curcumin results in increased expression of BCOR mRNA |
CTD |
PMID:17198877 |
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NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions increases expression affects expression |
EXP ISO |
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein] Curcumin results in increased expression of BDNF protein Curcumin affects the expression of BDNF protein [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA] |
CTD |
PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 PMID:27966075 PMID:29723552 PMID:32735850 PMID:34577062 More...
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of BECN1 protein Curcumin results in decreased expression of BECN1 protein |
CTD |
PMID:34634291 PMID:36640941 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bgn |
biglycan |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] |
CTD |
PMID:20605902 PMID:27430728 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] |
CTD |
PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 PMID:17671737 PMID:20727180 PMID:23452621 More...
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions increases expression decreases expression |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein Curcumin results in increased expression of BIRC3 mRNA Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein |
CTD |
PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 PMID:17596214 PMID:19372569 PMID:27430728 More...
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein] Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein] Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein |
CTD |
PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 PMID:19235267 PMID:19372569 PMID:20727180 PMID:23452621 PMID:24664296 PMID:26409325 PMID:27430728 PMID:34047412 PMID:34233590 More...
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Birc7 |
baculoviral IAP repeat-containing 7 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BIRC7 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein |
CTD |
PMID:15911101 PMID:27430728 |
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NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
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G |
Bmp2 |
bone morphogenetic protein 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of BMP2 mRNA |
CTD |
PMID:27237783 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Brca1 |
BRCA1, DNA repair associated |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] |
CTD |
PMID:27996348 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Bsg |
basigin |
decreases response to substance |
ISO |
BSG protein results in decreased susceptibility to Curcumin |
CTD |
PMID:18379992 |
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NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
Curcumin results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
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NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C1qb |
complement C1q B chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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G |
C3 |
complement C3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4b |
complement C4B |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] |
CTD |
PMID:18200517 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
ISO EXP |
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein] |
CTD |
PMID:22911773 PMID:29723552 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Capg |
capping actin protein, gelsolin like |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
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G |
Car9 |
carbonic anhydrase 9 |
decreases expression |
EXP |
Curcumin results in decreased expression of CAR9 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Casp1 |
caspase 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP1 mRNA Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP1 mRNA] [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP1 protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA] |
CTD |
PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475 PMID:38301994 PMID:38369055 More...
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP12 protein Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein] |
CTD |
PMID:21793155 PMID:25541178 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp2 |
caspase 2 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP2 mRNA Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA] |
CTD |
PMID:16101141 PMID:38369055 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases cleavage increases activity decreases activity increases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of and results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]] Curcumin results in decreased expression of CASP3 protein modified form Curcumin results in increased cleavage of CASP3 protein Curcumin results in decreased activity of CASP3 protein [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form] Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein |
CTD |
PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 PMID:17096185 PMID:17148446 PMID:17277231 PMID:17332930 PMID:17351913 PMID:17363495 PMID:17440100 PMID:17640567 PMID:17671742 PMID:17885582 PMID:18555241 PMID:19235267 PMID:19294764 PMID:19373661 PMID:19401701 PMID:20127174 PMID:20605902 PMID:20869986 PMID:21397623 PMID:21450334 PMID:21594647 PMID:21595920 PMID:22523229 PMID:23267840 PMID:23555722 PMID:23710286 PMID:24863870 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27375190 PMID:27430728 PMID:27535828 PMID:27966075 PMID:28681665 PMID:29315967 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30463061 PMID:30935902 PMID:31712109 PMID:31820278 PMID:32569592 PMID:33582110 PMID:33617879 PMID:33729022 PMID:34042043 PMID:34577062 PMID:34675983 PMID:34994998 PMID:35817260 PMID:36037877 PMID:36178099 PMID:36305173 PMID:38348716 PMID:38369055 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases expression |
ISO |
Curcumin results in increased expression of CASP4 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp7 |
caspase 7 |
multiple interactions increases expression decreases expression |
ISO EXP |
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA] Curcumin results in increased expression of CASP7 protein Curcumin results in decreased expression of CASP7 mRNA |
CTD |
PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 PMID:38369055 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions increases cleavage decreases expression |
ISO EXP |
Curcumin results in increased activity of CASP8 protein Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP8 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA] Curcumin results in increased cleavage of CASP8 protein Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein] |
CTD |
PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 PMID:23267840 PMID:23452621 PMID:25541178 PMID:27430728 PMID:33582110 PMID:38369055 More...
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
decreases expression multiple interactions increases activity increases expression increases cleavage |
ISO EXP |
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA] Curcumin results in increased activity of CASP9 protein Curcumin results in increased expression of CASP9 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein Curcumin results in increased cleavage of CASP9 protein [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]] |
CTD |
PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 PMID:17440100 PMID:17671742 PMID:18555241 PMID:19095035 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:27375190 PMID:28681665 PMID:31628941 PMID:31712109 PMID:33582110 PMID:33729022 PMID:34994998 PMID:36037877 PMID:38369055 More...
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases expression increases activity |
ISO EXP |
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein] Curcumin results in increased expression of CAT protein Curcumin results in increased activity of CAT protein Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein] Curcumin results in increased expression of CAT mRNA [Curcumin co-treated with alpha-Tocopherol] inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein] |
CTD |
PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 PMID:18392098 PMID:19481068 PMID:19631675 PMID:19913070 PMID:19914224 PMID:20112103 PMID:20593964 PMID:21574897 PMID:21976817 PMID:22704994 PMID:24113306 PMID:24347089 PMID:24760747 PMID:25123790 PMID:25169090 PMID:25233897 PMID:25461551 PMID:27375190 PMID:28951138 PMID:29205955 PMID:29315967 PMID:30138604 PMID:30423402 PMID:30934151 PMID:30946834 PMID:31081568 PMID:31199764 PMID:31330227 PMID:31407471 PMID:31521693 PMID:31714633 PMID:32735850 PMID:33350580 PMID:34577062 PMID:34758851 PMID:34802538 PMID:35063475 PMID:35817260 PMID:36924976 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] |
CTD |
PMID:25541467 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Ccar1 |
cell division cycle and apoptosis regulator 1 |
increases expression |
ISO |
Curcumin results in increased expression of CCAR1 protein |
CTD |
PMID:21594647 |
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NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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G |
Ccdc116 |
coiled-coil domain containing 116 |
increases expression |
ISO |
Curcumin results in increased expression of CCDC116 mRNA |
CTD |
PMID:18200517 |
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NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression increases expression |
ISO EXP |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]] Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA] Curcumin results in increased expression of CCL2 mRNA |
CTD |
PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 PMID:19152916 PMID:20712904 PMID:22683883 PMID:23452621 PMID:33952798 More...
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccn2 |
cellular communication network factor 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA] |
CTD |
PMID:17965732 PMID:19764552 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein] Curcumin results in decreased expression of CCNA2 protein |
CTD |
PMID:23222814 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein |
CTD |
PMID:17148446 PMID:18719366 PMID:19401701 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression decreases expression increases degradation |
ISO EXP |
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] Curcumin results in increased expression of CCND1 mRNA Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA] Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein |
CTD |
PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 PMID:16243823 PMID:16959222 PMID:17041101 PMID:17148446 PMID:17440100 PMID:17531121 PMID:17602960 PMID:17640567 PMID:17885582 PMID:18156803 PMID:18226269 PMID:18316600 PMID:18593936 PMID:18640131 PMID:18790744 PMID:18829502 PMID:19189304 PMID:19372569 PMID:19501152 PMID:19573523 PMID:20727180 PMID:24211270 PMID:24508477 PMID:25822711 PMID:25963729 PMID:27996348 PMID:30935902 PMID:34233590 PMID:36640941 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein] Curcumin results in decreased expression of CCND3 protein |
CTD |
PMID:23222814 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
decreases expression multiple interactions increases degradation |
ISO EXP |
Curcumin results in decreased expression of CCNE1 protein Curcumin results in decreased expression of CCNE1 mRNA Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] |
CTD |
PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccpg1 |
cell cycle progression 1 |
increases expression |
ISO |
Curcumin results in increased expression of CCPG1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of CCR2 mRNA |
CTD |
PMID:18403477 |
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NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] |
CTD |
PMID:18180316 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd36 |
CD36 molecule |
decreases expression increases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CD36 mRNA Curcumin results in increased expression of CD36 mRNA Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein] Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein |
CTD |
PMID:16713233 PMID:23386263 PMID:23603106 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40 |
CD40 molecule |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CD40 mRNA CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein] [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein |
CTD |
PMID:16101141 PMID:27430728 PMID:35549587 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein |
CTD |
PMID:27430728 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd44 |
CD44 molecule |
increases expression |
ISO |
Curcumin results in increased expression of CD44 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd47 |
Cd47 molecule |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
decreases expression |
ISO |
Curcumin results in decreased expression of CD55 mRNA |
CTD |
PMID:17999991 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cdc14b |
cell division cycle 14B |
increases expression |
ISO |
Curcumin results in increased expression of CDC14B mRNA |
CTD |
PMID:17198877 |
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NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
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G |
Cdc20 |
cell division cycle 20 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDC20 mRNA |
CTD |
PMID:22258452 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc25c |
cell division cycle 25C |
increases phosphorylation |
ISO |
Curcumin results in increased phosphorylation of CDC25C protein |
CTD |
PMID:19401701 |
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NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of CDH1 protein Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein] [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein] |
CTD |
PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:35487055 PMID:36640941 More...
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh11 |
cadherin 11 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDH11 protein |
CTD |
PMID:18025290 |
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NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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G |
Cdh17 |
cadherin 17 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDH17 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
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G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein] Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]] |
CTD |
PMID:26191140 PMID:34233590 PMID:35549587 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
EXP ISO |
Curcumin results in decreased expression of CDK1 mRNA Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein |
CTD |
PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein] Curcumin inhibits the reaction [Atrazine results in decreased expression of CDK2 mRNA]; Curcumin inhibits the reaction [Atrazine results in decreased expression of CDK2 protein] Curcumin results in decreased expression of CDK2 protein Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein |
CTD |
PMID:19501152 PMID:23222814 PMID:26409325 PMID:38301994 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein |
CTD |
PMID:18156803 PMID:24211270 PMID:26409325 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk5 |
cyclin-dependent kinase 5 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK5 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDK6 protein |
CTD |
PMID:18156803 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdk7 |
cyclin-dependent kinase 7 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK7 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdk9 |
cyclin-dependent kinase 9 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK9 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein] [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein] Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] |
CTD |
PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 PMID:18156803 PMID:18161303 PMID:18226269 PMID:18316600 PMID:18593936 PMID:20153625 PMID:23222814 PMID:25644192 PMID:25822711 PMID:27132804 PMID:27430728 PMID:28681665 PMID:30935902 PMID:33582110 PMID:38301994 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein] [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein] Curcumin results in decreased expression of CDKN1B protein |
CTD |
PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 PMID:21594647 PMID:25822711 PMID:27132804 PMID:27430728 PMID:36352148 More...
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of CDKN2A protein Curcumin results in increased expression of CDKN2A protein |
CTD |
PMID:17148446 PMID:18156803 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cdkn2d |
cyclin dependent kinase inhibitor 2D |
decreases expression |
EXP |
Curcumin results in decreased expression of CDKN2D mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
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G |
Cdx2 |
caudal type homeo box 2 |
increases expression |
EXP ISO |
Curcumin results in increased expression of CDX2 mRNA |
CTD |
PMID:18299980 PMID:27237783 |
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NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] |
CTD |
PMID:19297423 PMID:28595985 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces3a |
carboxylesterase 3a |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr19:32,992,386...33,000,562
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] Curcumin results in decreased expression of CFLAR protein |
CTD |
PMID:16173963 PMID:16219905 PMID:23452621 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases activity affects localization |
ISO |
[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form Curcumin affects the localization of CFTR protein mutant form Curcumin affects the folding of and affects the localization of CFTR protein mutant form |
CTD |
PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] |
CTD |
PMID:21839772 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chek1 |
checkpoint kinase 1 |
decreases response to substance multiple interactions increases activity increases phosphorylation |
ISO |
CHEK1 protein results in decreased susceptibility to Curcumin Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] Curcumin results in increased activity of CHEK1 protein Curcumin results in increased phosphorylation of CHEK1 protein |
CTD |
PMID:18602917 PMID:19401701 PMID:27996348 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
[Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein] Curcumin results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:21134073 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] |
CTD |
PMID:24952339 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions decreases activity |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein] Curcumin results in decreased activity of CHUK protein |
CTD |
PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Ckb |
creatine kinase B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] |
CTD |
PMID:21378372 PMID:29315967 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [Gentamicins results in increased secretion of CKM protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] |
CTD |
PMID:21378372 PMID:29315967 PMID:38056816 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Clca4 |
chloride channel accessory 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
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G |
Clcn6 |
chloride voltage-gated channel 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of CLCN6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
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G |
Cldn1 |
claudin 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein] |
CTD |
PMID:35817260 |
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NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Cldn2 |
claudin 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] |
CTD |
PMID:25119790 |
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NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
EXP ISO |
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]] Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA] Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein |
CTD |
PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 PMID:18006644 PMID:28700904 PMID:32718261 More...
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col27a1 |
collagen type XXVII alpha 1 chain |
increases expression |
EXP |
Curcumin results in increased expression of COL27A1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:76,647,302...76,765,989
Ensembl chr 5:76,647,429...76,765,174
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G |
Col2a1 |
collagen type II alpha 1 chain |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein [resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein |
CTD |
PMID:18321735 PMID:19889203 |
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NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] |
CTD |
PMID:22683883 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col4a1 |
collagen type IV alpha 1 chain |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of COL4A1 mRNA Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA] Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA] |
CTD |
PMID:18200517 PMID:21594647 PMID:28700904 |
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NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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G |
Col4a2 |
collagen type IV alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
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G |
Col4a5 |
collagen type IV alpha 5 chain |
decreases expression |
ISO |
Curcumin results in decreased expression of COL4A5 mRNA |
CTD |
PMID:15713895 |
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NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692
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G |
Col5a1 |
collagen type V alpha 1 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Curcumin results in increased expression of CPT1A mRNA |
CTD |
PMID:19297423 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions increases phosphorylation |
EXP ISO |
Curcumin results in increased expression of CREB1 mRNA 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein] [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein] Curcumin results in increased phosphorylation of CREB1 protein |
CTD |
PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 PMID:32735850 More...
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3 |
cAMP responsive element binding protein 3 |
increases expression |
EXP |
Curcumin results in increased expression of CREB3 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390
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G |
Crebbp |
CREB binding protein |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] |
CTD |
PMID:22258452 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Crp |
C-reactive protein |
multiple interactions |
EXP ISO |
Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein] |
CTD |
PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
ISO EXP |
Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein] [Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:9764755 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cs |
citrate synthase |
affects expression |
EXP |
Curcumin affects the expression of CS mRNA |
CTD |
PMID:18539377 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] |
CTD |
PMID:15129424 |
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NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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G |
Csf1r |
colony stimulating factor 1 receptor |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] Curcumin results in increased expression of CSF1R mRNA |
CTD |
PMID:15129424 PMID:22714040 |
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NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
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G |
Csf2ra |
colony stimulating factor 2 receptor subunit alpha |
increases expression |
ISO |
Curcumin results in increased expression of CSF2RA mRNA |
CTD |
PMID:22714040 |
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NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128
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G |
Csf2rb |
colony stimulating factor 2 receptor subunit beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression increases expression multiple interactions decreases phosphorylation increases degradation |
ISO EXP |
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein Curcumin results in increased expression of CTNNB1 mRNA Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein Curcumin results in decreased phosphorylation of CTNNB1 protein [piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein] Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein |
CTD |
PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 PMID:27645308 PMID:30935902 More...
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] Curcumin analog results in decreased expression of CTSB mRNA |
CTD |
PMID:8534267 PMID:26409325 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsd |
cathepsin D |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] Curcumin analog results in decreased expression of CTSD mRNA |
CTD |
PMID:8534267 PMID:26409325 |
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctsl |
cathepsin L |
decreases expression |
ISO |
Curcumin results in decreased expression of CTSL protein |
CTD |
PMID:34138966 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctss |
cathepsin S |
decreases expression |
ISO |
Curcumin results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
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NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cul3 |
cullin 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 mRNA] |
CTD |
PMID:38272317 |
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NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions decreases expression |
ISO |
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA] Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein |
CTD |
PMID:17999991 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] |
CTD |
PMID:18660423 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
Curcumin results in decreased expression of CXCL14 mRNA |
CTD |
PMID:19555370 |
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NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA] Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein] NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA] |
CTD |
PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein] NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA] |
CTD |
PMID:17999991 PMID:27194111 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
increases expression |
ISO |
Curcumin results in increased expression of CXCR1 protein |
CTD |
PMID:12216086 |
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NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
increases expression |
ISO |
Curcumin results in increased expression of CXCR2 protein |
CTD |
PMID:12216086 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CXCR4 mRNA Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA] |
CTD |
PMID:17198877 PMID:18660423 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cycs |
cytochrome c, somatic |
affects localization multiple interactions |
ISO |
Curcumin affects the localization of CYCS protein [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein |
CTD |
PMID:19235267 PMID:27430728 PMID:33617879 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases activity increases expression decreases activity decreases expression |
ISO EXP |
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA] Curcumin results in increased activity of CYP1A1 protein Curcumin results in increased expression of CYP1A1 mRNA Curcumin results in decreased activity of CYP1A1 protein Curcumin results in decreased expression of CYP1A1 mRNA Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 PMID:17880909 PMID:18321868 PMID:19018768 PMID:20015472 PMID:20816778 PMID:22867086 PMID:27041069 PMID:34802538 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity multiple interactions |
ISO EXP |
Curcumin results in decreased activity of CYP1A2 protein Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA] Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] |
CTD |
PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein] Curcumin results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:17637178 PMID:19018768 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA Curcumin results in increased expression of CYP24A1 protein |
CTD |
PMID:20153625 |
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NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
affects expression multiple interactions |
EXP |
Curcumin affects the expression of CYP2B1 protein Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine] |
CTD |
PMID:16805852 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c7 |
cytochrome P450, family 2, subfamily c, polypeptide 7 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein] |
CTD |
PMID:16288784 |
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NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of CYP2D6 mRNA |
CTD |
PMID:33582110 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Curcumin affects the expression of CYP2E1 protein Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA] Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein] Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein] Curcumin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases expression multiple interactions increases expression |
ISO |
Curcumin results in decreased expression of CYP3A4 mRNA [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] Curcumin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 PMID:20816778 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Curcumin results in increased expression of CYP4A3 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyth4 |
cytohesin 4 |
increases expression |
ISO |
Curcumin results in increased expression of CYTH4 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741
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G |
Daxx |
death-domain associated protein |
increases expression |
ISO |
Curcumin results in increased expression of DAXX mRNA |
CTD |
PMID:16101141 |
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NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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G |
Dbn1 |
drebrin 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] |
CTD |
PMID:23333261 |
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NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
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G |
Dcn |
decorin |
increases expression |
ISO |
Curcumin results in increased expression of DCN mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Dcx |
doublecortin |
multiple interactions increases expression |
EXP ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA] Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein] Curcumin results in increased expression of DCX mRNA |
CTD |
PMID:25963729 PMID:32735850 |
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NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein |
CTD |
PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 PMID:27996348 PMID:29723631 More...
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
decreases expression increases expression |
ISO EXP |
Curcumin results in decreased expression of DDIT4L mRNA Curcumin results in increased expression of DDIT4L mRNA |
CTD |
PMID:17999991 PMID:18299980 |
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NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Derl1 |
derlin 1 |
increases expression |
ISO |
Curcumin results in increased expression of DERL1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
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G |
Des |
desmin |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Gentamicins results in increased expression of DES mRNA] |
CTD |
PMID:38056816 |
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NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein Curcumin results in decreased expression of DFFB protein |
CTD |
PMID:21397623 PMID:22714040 |
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NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of DHCR24 mRNA Curcumin affects the expression of DHCR24 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of DHCR7 mRNA Curcumin results in decreased expression of DHCR7 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dhrs1 |
dehydrogenase/reductase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of DHRS1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
affects localization multiple interactions increases expression increases response to substance |
ISO |
Curcumin affects the localization of DIABLO protein [arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein Curcumin results in increased expression of DIABLO mRNA DIABLO protein results in increased susceptibility to Curcumin |
CTD |
PMID:17277231 PMID:23555722 PMID:27430728 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
decreases expression multiple interactions |
EXP |
Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein] |
CTD |
PMID:25963729 |
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NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] |
CTD |
PMID:29723552 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Curcumin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein] |
CTD |
PMID:32980475 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression affects expression multiple interactions increases activity |
ISO |
Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein Curcumin analog affects the expression of DNMT1 protein Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein] Curcumin analog results in decreased expression of DNMT1 protein |
CTD |
PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
ISO |
Curcumin results in decreased expression of DNMT3A mRNA Curcumin analog results in decreased expression of DNMT3A protein |
CTD |
PMID:23593078 PMID:26991801 PMID:29228771 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
ISO |
Curcumin results in decreased expression of DNMT3B mRNA Curcumin analog results in decreased expression of DNMT3B protein |
CTD |
PMID:23593078 PMID:26991801 PMID:29228771 |
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NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dram1 |
DNA-damage regulated autophagy modulator 1 |
increases expression |
ISO |
Curcumin results in increased expression of DRAM1 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] |
CTD |
PMID:27966075 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of DUSP1 mRNA Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein] |
CTD |
PMID:15713895 PMID:20885979 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression |
ISO |
Curcumin results in increased expression of DUSP10 mRNA |
CTD |
PMID:15713895 PMID:17151092 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
Curcumin results in increased expression of DUSP5 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dvl1 |
dishevelled segment polarity protein 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein] Curcumin results in decreased expression of DVL1 protein Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein |
CTD |
PMID:19573523 PMID:25963729 |
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NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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G |
Dynll1 |
dynein light chain LC8-type 1 |
increases expression |
ISO |
Curcumin results in increased expression of DYNLL1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
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G |
Dyrk2 |
dual specificity tyrosine phosphorylation regulated kinase 2 |
decreases activity multiple interactions |
ISO |
Curcumin results in decreased activity of DYRK2 protein [Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein |
CTD |
PMID:33617879 |
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NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of E2F1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f5 |
E2F transcription factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of E2F5 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
EXP |
Curcumin results in increased expression of ECH1 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Edaradd |
EDAR associated via death domain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] |
CTD |
PMID:23452621 |
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NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Curcumin results in increased expression of EDEM1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Edil3 |
EGF like repeats and discoidin domains 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of EDIL3 mRNA |
CTD |
PMID:18421014 |
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NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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G |
Egf |
epidermal growth factor |
multiple interactions decreases activity |
ISO EXP |
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] Curcumin results in decreased activity of EGF protein Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein] |
CTD |
PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases phosphorylation decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein] Curcumin results in decreased phosphorylation of EGFR protein Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; Curcumin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA] Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein |
CTD |
PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 PMID:18006644 PMID:18214481 PMID:18332871 PMID:18719366 PMID:24508477 PMID:26409325 PMID:34994998 PMID:37858842 More...
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein] Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein Curcumin results in decreased expression of EGR1 mRNA |
CTD |
PMID:17198877 PMID:17999991 PMID:18316600 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of EIF1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate results in increased expression of EIF2AK3 protein] |
CTD |
PMID:34784780 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein] Curcumin results in decreased expression of EIF4EBP1 protein |
CTD |
PMID:18790744 PMID:23222814 PMID:34634291 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Eif4g1 |
eukaryotic translation initiation factor 4 gamma 1 |
decreases phosphorylation |
ISO |
Curcumin results in decreased phosphorylation of EIF4G1 protein |
CTD |
PMID:18790744 |
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NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
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G |
Elf2 |
E74 like ETS transcription factor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of ELF2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions increases phosphorylation |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:18316600 PMID:23452621 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Emb |
embigin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
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G |
Eno1 |
enolase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ENO1 mRNA |
CTD |
PMID:16880289 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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G |
Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
increases expression |
EXP |
Curcumin results in increased expression of ENTPD5 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions decreases activity decreases expression affects localization |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]] Curcumin results in decreased activity of EP300 protein Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein] Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein |
CTD |
PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707 |
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NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] |
CTD |
PMID:20554536 |
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NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Epcam |
epithelial cell adhesion molecule |
multiple interactions decreases expression |
ISO |
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein] Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein |
CTD |
PMID:33539684 |
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NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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G |
Epo |
erythropoietin |
decreases expression |
ISO |
Curcumin results in decreased expression of EPO mRNA |
CTD |
PMID:16880289 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Epx |
eosinophil peroxidase |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein] |
CTD |
PMID:34998855 |
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NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions increases response to substance increases degradation decreases expression |
ISO |
[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog Curcumin analog results in increased degradation of ERBB2 protein Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein |
CTD |
PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 PMID:34291863 More...
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
multiple interactions decreases expression |
ISO |
Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein] Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA |
CTD |
PMID:15713895 PMID:17918158 PMID:26409325 |
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NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
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G |
Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
multiple interactions decreases expression |
ISO EXP |
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein] Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA] Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein |
CTD |
PMID:17596214 PMID:21493726 PMID:22228707 |
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NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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G |
Ercc4 |
ERCC excision repair 4, endonuclease catalytic subunit |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA] Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein] Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein |
CTD |
PMID:22228707 |
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NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
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G |
Erlec1 |
endoplasmic reticulum lectin 1 |
increases expression |
ISO |
Curcumin results in increased expression of ERLEC1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of ERN1 mRNA Curcumin results in increased expression of ERN1 mRNA |
CTD |
PMID:17999991 PMID:29723631 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol affects the localization of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein] Curcumin results in decreased expression of ESR1 protein |
CTD |
PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 PMID:38229314 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Ets2 |
ETS proto-oncogene 2, transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of ETS2 protein |
CTD |
PMID:17332326 |
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NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] |
CTD |
PMID:18565277 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] |
CTD |
PMID:18983524 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fabp3 |
fatty acid binding protein 3 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Gentamicins results in increased expression of FABP3 mRNA] |
CTD |
PMID:38056816 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fadd |
Fas associated via death domain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fads1 |
fatty acid desaturase 1 |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of FADS1 mRNA Curcumin results in decreased expression of FADS1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fads2 |
fatty acid desaturase 2 |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of FADS2 mRNA Curcumin affects the expression of FADS2 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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G |
Fam120b |
family with sequence similarity 120 member B |
decreases expression |
ISO |
Curcumin results in decreased expression of FAM120B mRNA |
CTD |
PMID:17999991 |
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NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
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G |
Fam8a1 |
family with sequence similarity 8, member A1 |
increases expression |
ISO |
Curcumin results in increased expression of FAM8A1 mRNA |
CTD |
PMID:38229314 |
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NCBI chr17:18,026,601...18,035,509
Ensembl chr17:18,026,601...18,035,470
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] Curcumin results in decreased expression of FANCD2 mRNA |
CTD |
PMID:24124520 |
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NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fanci |
FA complementation group I |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] Curcumin results in decreased expression of FANCI mRNA |
CTD |
PMID:24124520 |
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NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO EXP |
[arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein Curcumin inhibits the reaction [fenpropathrin results in increased expression of FAS mRNA] |
CTD |
PMID:27430728 PMID:38369055 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions decreases expression |
ISO EXP |
[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA] Curcumin inhibits the reaction [fenpropathrin results in increased expression of FASL mRNA] Curcumin results in decreased expression of FASLG mRNA |
CTD |
PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 PMID:38369055 More...
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein Curcumin results in decreased expression of FASN mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbln2 |
fibulin 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
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G |
Fbxo6 |
F-box protein 6 |
increases expression |
ISO |
Curcumin results in increased expression of FBXO6 mRNA |
CTD |
PMID:38229314 |
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NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525
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G |
Fcgr3a |
Fc gamma receptor 3A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of FDFT1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fdps |
farnesyl diphosphate synthase |
increases expression decreases expression affects expression |
ISO EXP |
Curcumin results in increased expression of FDPS mRNA Curcumin results in decreased expression of FDPS mRNA Curcumin affects the expression of FDPS mRNA |
CTD |
PMID:16713233 PMID:27208389 |
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NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of FGF2 protein Curcumin results in increased expression of FGF2 protein |
CTD |
PMID:23555722 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgf5 |
fibroblast growth factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of FGF5 mRNA |
CTD |
PMID:27237783 |
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NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FGFR2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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G |
Filip1l |
filamin A interacting protein 1-like |
increases expression |
ISO |
Curcumin results in increased expression of FILIP1L mRNA |
CTD |
PMID:21594647 |
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NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] |
CTD |
PMID:28698153 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein] Curcumin results in decreased expression of FLT1 protein |
CTD |
PMID:18593936 PMID:23845850 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein] Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] Curcumin results in decreased expression of FN1 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA] |
CTD |
PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fntb |
farnesyltransferase, CAAX box, subunit beta |
increases expression |
ISO |
Curcumin results in increased expression of FNTB mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression multiple interactions increases expression |
ISO EXP |
Curcumin results in decreased expression of FOS mRNA Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA] Curcumin results in increased expression of FOS mRNA [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein] |
CTD |
PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein] Curcumin results in increased ubiquitination of FOSL1 protein |
CTD |
PMID:17148446 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of FOSL2 mRNA Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein] |
CTD |
PMID:17148446 PMID:17999991 |
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NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxa1 |
forkhead box A1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] |
CTD |
PMID:22258452 |
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NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G |
Foxa2 |
forkhead box A2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FOXA2 mRNA |
CTD |
PMID:27237783 |
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NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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G |
Foxf2 |
forkhead box F2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FOXF2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
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G |
Foxo1 |
forkhead box O1 |
increases expression decreases phosphorylation |
ISO |
Curcumin results in increased expression of FOXO1 mRNA Curcumin results in decreased phosphorylation of FOXO1 protein |
CTD |
PMID:18403477 PMID:18790744 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Fpr3 |
formyl peptide receptor 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:58,884,427...58,893,472
Ensembl chr 1:58,845,118...58,893,467
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] |
CTD |
PMID:31199764 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fstl1 |
follistatin-like 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FTH1 protein] |
CTD |
PMID:34787501 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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