phosphinic acids - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	phosphinic acids	go back to main search page
Accession:	CHEBI:26044	browse the term

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Rat (57) Mouse (57) Human (58) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (57)

fosinopril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

decreases response to substance

ABCC1 protein results in decreased susceptibility to Fosinopril

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases response to substance
multiple interactions
increases export

ABCC2 protein results in decreased susceptibility to Fosinopril
ABCC2 protein affects the reaction [Fosinopril affects the export of Methotrexate]
desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Methotrexate inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

adiponectin receptor 2

increases expression

fosinopril increases expression of adipor2 mRNA in rat liver

RGD

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

alpha-fetoprotein

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

angiotensinogen

decreases expression

Fosinopril results in decreased expression of AGT protein

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

bone morphogenetic protein receptor type 2

multiple interactions

Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

cyclin D1

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

glutamic--pyruvic transaminase

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

Klotho

increases expression

Fosinopril results in increased expression of KL mRNA; Fosinopril results in increased expression of KL protein

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

matrix metallopeptidase 2

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Fosinopril results in decreased expression of MMP9 mRNA; Fosinopril results in decreased expression of MMP9 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

nuclear factor kappa B subunit 1

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 3

affects expression

Fosinopril affects the expression of NOS3 mRNA; Fosinopril affects the expression of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

phosphodiesterase 1A

affects expression

Fosinopril affects the expression of PDE1A mRNA; Fosinopril affects the expression of PDE1A protein

NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874

G

phosphodiesterase 1C

affects expression

Fosinopril affects the expression of PDE1C mRNA; Fosinopril affects the expression of PDE1C protein

NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family E member 1

decreases expression
multiple interactions

Fosinopril results in decreased expression of SERPINE1 mRNA; Fosinopril results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 15 member 1

multiple interactions

Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Fosinopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

transforming growth factor, beta 1

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

decreases expression
multiple interactions

Fosinopril results in decreased expression of TIMP1 mRNA; Fosinopril results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

glufosinate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-kinase 1

decreases expression

phosphinothricin results in decreased expression of ALPK1 mRNA

NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157

G

activity-regulated cytoskeleton-associated protein

multiple interactions
increases expression

Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA]

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

armadillo repeat containing 2

decreases expression

phosphinothricin results in decreased expression of ARMC2 mRNA

NCBI chr20:45,395,859...45,501,808
Ensembl chr20:45,394,127...45,504,819

G

coiled-coil domain containing 180

decreases expression

phosphinothricin results in decreased expression of CCDC180 mRNA

NCBI chr 5:60,154,883...60,223,508
Ensembl chr 5:60,154,910...60,223,522

G

cilia and flagella associated protein 43

decreases expression

phosphinothricin results in decreased expression of CFAP43 mRNA

NCBI chr 1:246,625,259...246,712,438
Ensembl chr 1:246,625,262...246,712,443

G

cilia and flagella associated protein 61

decreases expression

phosphinothricin results in decreased expression of CFAP61 mRNA

NCBI chr 3:133,354,400...133,633,310
Ensembl chr 3:133,354,197...133,633,320

G

CF transmembrane conductance regulator

decreases expression

phosphinothricin results in decreased expression of CFTR mRNA

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

double PHD fingers 3

decreases expression

phosphinothricin results in decreased expression of DPF3 mRNA

NCBI chr 6:102,841,403...103,125,558
Ensembl chr 6:102,846,029...103,125,493

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

phosphinothricin results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FMR1 autosomal homolog 1

increases expression

phosphinothricin results in increased expression of FXR1 mRNA

NCBI chr 2:116,884,167...116,937,590
Ensembl chr 2:116,884,248...116,937,590

G

glial fibrillary acidic protein

increases expression

phosphinothricin results in increased expression of GFAP mRNA; phosphinothricin results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamate-ammonia ligase

increases expression
multiple interactions

phosphinothricin results in increased expression of GLUL mRNA
phosphinothricin results in increased expression of and results in increased activity of GLUL protein

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

inositol polyphosphate-5-phosphatase A

decreases expression

phosphinothricin results in decreased expression of INPP5A mRNA

NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428

G

IQ motif and ankyrin repeat containing 1

decreases expression

phosphinothricin results in decreased expression of IQANK1 mRNA

NCBI chr 7:107,724,962...107,759,163
Ensembl chr 7:107,724,997...107,759,162

G

potassium voltage-gated channel subfamily D member 3

decreases expression

phosphinothricin results in decreased expression of KCND3 mRNA

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

G

kallikrein 1-related peptidase C10

increases secretion

phosphinothricin results in increased secretion of KLK3 protein

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

killer cell lectin like receptor G1

decreases expression

phosphinothricin results in decreased expression of KLRG1 mRNA

NCBI chr 4:155,455,465...155,467,301
Ensembl chr 4:155,455,495...155,467,424

G

membrane spanning 4-domains A14

increases expression

phosphinothricin results in increased expression of MS4A14 mRNA

NCBI chr 1:207,949,423...207,964,937
Ensembl chr 1:207,949,426...207,964,937

G

neurofilament heavy chain

affects expression

phosphinothricin affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

outer dynein arm docking complex subunit 2

decreases expression

phosphinothricin results in decreased expression of ODAD2 mRNA

NCBI chr17:55,216,877...55,409,872
Ensembl chr17:55,218,991...55,409,399

G

paternally expressed 3

decreases expression

phosphinothricin results in decreased expression of PEG3 mRNA

NCBI chr 1:67,097,874...67,124,692
Ensembl chr 1:67,097,904...67,124,671

G

phosphorylase kinase catalytic subunit gamma 2

increases expression

phosphinothricin results in increased expression of PHKG2 mRNA

NCBI chr 1:182,184,362...182,197,124
Ensembl chr 1:182,184,650...182,197,124

G

phospholipase C, delta 4

decreases expression

phosphinothricin results in decreased expression of PLCD4 mRNA

NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453

G

protein phosphatase 1, regulatory subunit 36

increases expression

phosphinothricin results in increased expression of PPP1R36 mRNA

NCBI chr 6:95,138,526...95,159,102
Ensembl chr 6:95,139,007...95,159,102

G

phosphatase and tensin homolog

affects expression

phosphinothricin affects the expression of PTEN mRNA

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

solute carrier family 17 member 9

decreases expression

phosphinothricin results in decreased expression of SLC17A9 mRNA

NCBI chr 3:167,839,246...167,857,462
Ensembl chr 3:167,839,385...167,855,985

G

solute carrier family 8 member B1

decreases expression

phosphinothricin results in decreased expression of SLC8B1 mRNA

NCBI chr12:36,029,759...36,053,087
Ensembl chr12:36,029,760...36,053,031

G

sperm associated antigen 16

decreases expression

phosphinothricin results in decreased expression of SPAG16 mRNA

NCBI chr 9:71,333,005...72,252,772
Ensembl chr 9:71,332,992...72,252,708

G

sulfatase 1

decreases expression

phosphinothricin results in decreased expression of SULF1 mRNA

NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584

G

synaptotagmin 10

decreases expression

phosphinothricin results in decreased expression of SYT10 mRNA

NCBI chr 7:120,857,698...120,920,863
Ensembl chr 7:120,862,972...120,920,863

G

Tax1 binding protein 1

increases expression

phosphinothricin results in increased expression of TAX1BP1 mRNA

NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100

G

transmembrane O-mannosyltransferase targeting cadherins 1

decreases expression

phosphinothricin results in decreased expression of TMTC1 mRNA

NCBI chr 4:181,142,937...181,357,979
Ensembl chr 4:181,146,251...181,359,289

G

Wnt family member 2

decreases expression

phosphinothricin results in decreased expression of WNT2 mRNA

NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402

G

zinc finger protein, multitype 2

decreases expression

phosphinothricin results in decreased expression of ZFPM2 mRNA

NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
atom	19872
nonmetal atom	19794
phosphorus atom	14729
phosphorus molecular entity	14729
phosphorus oxoacids and derivatives	14725
phosphinic acids	57
(\{[(1R,2R)-2-(uracil-1-yl)cyclopentyl]oxy\}methyl)phosphonic acid	0
2-(phosphinomethylidene)succinic acid	0
2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid +	34
2-phosphinomethylmalic acid	0
3-[hydroxy(oxido)phosphoranyl]pyruvic acid	0
N-acetylphosphinothricin +	0
bilanafos	0
dimethylphosphinic acid	0
diphenylphosphinic acid +	0
fosinoprilat +	23
phosphinic acid +	0
phosphinomethylisomalic acid	0
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
pnictogen	19072
phosphorus atom	14729
phosphorus molecular entity	14729
phosphorus oxoacids and derivatives	14725
phosphinic acids	57
(\{[(1R,2R)-2-(uracil-1-yl)cyclopentyl]oxy\}methyl)phosphonic acid	0
2-(phosphinomethylidene)succinic acid	0
2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid +	34
2-phosphinomethylmalic acid	0
3-[hydroxy(oxido)phosphoranyl]pyruvic acid	0
N-acetylphosphinothricin +	0
bilanafos	0
dimethylphosphinic acid	0
diphenylphosphinic acid +	0
fosinoprilat +	23
phosphinic acid +	0
phosphinomethylisomalic acid	0

paths to the root