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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pentaerythritol tetranitrate
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Accession:CHEBI:25879 term browser browse the term
Definition:A pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex.
Synonyms:related_synonym: 1,3-dinitrato-2,2-bis(nitratomethyl)propane;   2,2-bis((nitrooxy)methyl)-1,3-propanediol dinitrate;   2,2-bis((nitrooxy)methyl)-1,3-propanediol dinitrate ester;   2,2-bis(hydroxymethyl)-1,3-propanediol tetranitrate;   3-(nitrooxy)-2,2-bis[(nitrooxy)methyl]propyl nitrate;   Formula=C5H8N4O12;   InChI=1S/C5H8N4O12/c10-6(11)18-1-5(2-19-7(12)13,3-20-8(14)15)4-21-9(16)17/h1-4H2;   InChIKey=TZRXHJWUDPFEEY-UHFFFAOYSA-N;   PENT;   PETN;   SMILES=[O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O;   TEN;   corpent;   neopentanetetrayl nitrate;   nitropenta;   nitropentaerythrite;   nitropentaerythritol;   pentaerithrityl tetranitrate;   pentaerithrityli tetranitras;   pentaerythritylium tetranitricum;   penthrite;   tetranitrate de pentaerithrityle;   tetranitrato de pentaeritritilo;   tetranitropentaerythritol
 alt_id: CHEBI:31976
 xref: CAS:78-11-5;   Drug_Central:2087;   KEGG:D01721
 xref_mesh: MESH:D010417
 xref: Reaxys:1716886;   Wikipedia:Pentaerythritol_tetranitrate


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pentaerythritol tetranitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases response to substance
increases metabolic processing		 ISO
EXP		 [ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide; [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol
ALDH2 protein results in increased susceptibility to Pentaerythritol Tetranitrate
ALDH2 protein affects the metabolism of and results in increased activity of Pentaerythritol Tetranitrate		 CTD PMID:15331769 PMID:21156756 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Pentaerythritol Tetranitrate results in increased expression of FTH1 mRNA CTD PMID:17641250 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity		 ISO
EXP		 Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA
Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA; Pentaerythritol Tetranitrate results in increased expression of HMOX1 protein
Pentaerythritol Tetranitrate results in increased activity of HMOX1 protein		 CTD PMID:17092343 PMID:17541025 PMID:17641250 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Pentaerythritol Tetranitrate results in increased expression of NOS3 protein CTD PMID:17541025 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation		 EXP Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein] CTD PMID:15331769 PMID:17541025 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
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  CHEBI ontology 19899
    role 19869
      chemical role 19498
        explosive 4733
          pentaerythritol tetranitrate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19586
                        oxygen atom 19558
                          oxygen molecular entity 19558
                            hydroxides 19366
                              oxoacid 18804
                                pnictogen oxoacid 14996
                                  nitrogen oxoacid 283
                                    nitric acid 210
                                      nitrates 203
                                        nitrate ester 157
                                          pentaerythritol nitrate 5
                                            pentaerythritol tetranitrate 5
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