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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pelargonidin
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Accession:CHEBI:25863 term browser browse the term
Definition:An anthocyanidin cation that is flavylium substituted by a hydroxy groups at positions 3, 5, 7 and 4'.
Synonyms:exact_synonym: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromenylium
 related_synonym: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyrylium;   Formula=C15H11O5;   InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)15-13(19)7-11-12(18)5-10(17)6-14(11)20-15/h1-7H,(H3-,16,17,18,19)/p+1;   InChIKey=XVFMGWDSJLBXDZ-UHFFFAOYSA-O;   SMILES=Oc1ccc(cc1)-c1[o+]c2cc(O)cc(O)c2cc1O
 xref: CAS:134-04-3;   CAS:7690-51-9;   KEGG:C05904;   KNApSAcK:C00007232;   LIPID_MAPS_instance:LMPK12010003
 xref_mesh: MESH:C066957
 xref: PMID:15588587;   PMID:23419638;   Reaxys:1688614;   Wikipedia:Pelargonidin
 cyclic_relationship: is_conjugate_acid_of CHEBI:144777


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pelargonidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions		 ISO pelargonidin metabolite results in increased activity of AHR protein
[pelargonidin metabolite results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; pelargonidin binds to and results in increased activity of AHR protein		 CTD PMID:23419638 PMID:23735880 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 mRNA]; pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 protein] CTD PMID:30753810 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions		 ISO pelargonidin metabolite results in decreased activity of CYP1A1 protein; pelargonidin results in decreased activity of CYP1A1 protein
pelargonidin metabolite results in increased expression of CYP1A1 mRNA; pelargonidin results in increased expression of CYP1A1 mRNA
[pelargonidin metabolite results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; pelargonidin results in increased expression of and results in increased activity of CYP1A1 protein		 CTD PMID:23419638 PMID:23735880 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO pelargonidin results in increased expression of CYP1A2 mRNA CTD PMID:23419638 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO pelargonidin results in decreased expression of DNMT1 protein CTD PMID:31181187 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO pelargonidin results in decreased expression of DNMT3B protein CTD PMID:31181187 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO pelargonidin results in decreased expression of HDAC1 protein CTD PMID:31181187 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO pelargonidin results in decreased expression of HDAC2 protein CTD PMID:31181187 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO pelargonidin results in decreased expression of HDAC3 protein CTD PMID:31181187 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 decreases expression ISO pelargonidin results in decreased expression of HDAC4 protein CTD PMID:31181187 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac7 histone deacetylase 7 decreases expression ISO pelargonidin results in decreased expression of HDAC7 protein CTD PMID:31181187 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO pelargonidin results in increased expression of HMOX1 mRNA; pelargonidin results in increased expression of HMOX1 protein CTD PMID:31181187 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 mRNA]; pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:30753810 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:30753810 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:30753810 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:30753810 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases methylation
affects response to substance		 ISO pelargonidin results in decreased methylation of NFE2L2 promoter
NFE2L2 protein affects the susceptibility to pelargonidin		 CTD PMID:31181187 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18274639 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO pelargonidin results in increased expression of NQO1 mRNA; pelargonidin results in increased expression of NQO1 protein CTD PMID:31181187 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21341175 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO pelargonidin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]		 CTD PMID:18274639 PMID:30753810 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:30753810 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO pelargonidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]		 CTD PMID:18720166 PMID:30753810 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity EXP pelargonidin results in decreased activity of TXNRD1 protein modified form CTD PMID:16618767 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]; pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:30753810 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
pelargonidin 3-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO pelargonidin-3-glucoside results in decreased activity of CA1 protein CTD PMID:28445001 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO pelargonidin-3-glucoside results in decreased activity of CA2 protein CTD PMID:28445001 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
pelargonidin 3-O-beta-D-glucoside chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO pelargonidin-3-glucoside results in decreased activity of CA1 protein CTD PMID:28445001 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO pelargonidin-3-glucoside results in decreased activity of CA2 protein CTD PMID:28445001 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19901
    role 19871
      biological role 19869
        biochemical role 19576
          metabolite 19563
            eukaryotic metabolite 19387
              plant metabolite 18004
                pelargonidin 27
                  4'''-demalonylsalvianin 0
                  monardaein 0
                  pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside 0
                  pelargonidin 3-O-(6-O-malonyl-beta-D-glucoside) 0
                  pelargonidin 3-O-beta-D-glucoside + 2
                  pelargonidin 3-O-beta-D-sambubioside 0
                  pelargonidin 3-O-sophoroside 0
                  pelargonidin chloride 0
                  pelargonin 0
                  salvianin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19901
    subatomic particle 19899
      composite particle 19899
        hadron 19899
          baryon 19899
            nucleon 19899
              atomic nucleus 19899
                atom 19899
                  main group element atom 19838
                    p-block element atom 19838
                      carbon group element atom 19778
                        carbon atom 19775
                          organic molecular entity 19775
                            organic molecule 19728
                              organic cyclic compound 19519
                                organic heterocyclic compound 18898
                                  oxacycle 17925
                                    benzopyran 11982
                                      1-benzopyran 11736
                                        chromenes 4436
                                          chromene 148
                                            2H-chromene 148
                                              chromenyliums 148
                                                chromenylium 148
                                                  flavylium 148
                                                    anthocyanidin cation 148
                                                      5-hydroxyanthocyanidin 104
                                                        pelargonidin 27
                                                          4'''-demalonylsalvianin 0
                                                          monardaein 0
                                                          pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside 0
                                                          pelargonidin 3-O-(6-O-malonyl-beta-D-glucoside) 0
                                                          pelargonidin 3-O-beta-D-glucoside + 2
                                                          pelargonidin 3-O-beta-D-sambubioside 0
                                                          pelargonidin 3-O-sophoroside 0
                                                          pelargonidin chloride 0
                                                          pelargonin 0
                                                          salvianin 0
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