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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:organic oxide
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Accession:CHEBI:25701 term browser browse the term
Definition:An oxide in which the oxygen atom is bonded to a carbon atom.
Synonyms:related_synonym: organic oxides


show annotations for term's descendants           Sort by:
(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
decreases activity 		EXP artemisinin results in increased expression of ABCB1 mRNA
artemisinin results in decreased activity of ABCB1 protein 		CTD PMID:15761118 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,375 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions EXP artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,609...50,692,631 		JBrowse link
G CASP3 caspase 3 increases activity
increases expression 		ISO
EXP 		artemisinin results in increased activity of CASP3 protein
artemisinin results in increased expression of CASP3 protein 		CTD PMID:17948936 PMID:39778717 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,695...184,650,418 		JBrowse link
G CAT catalase decreases activity ISO artemisinin results in decreased activity of CAT protein CTD PMID:24876631 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,906...34,472,061 		JBrowse link
G CD44 CD44 molecule (IN blood group) decreases expression EXP artemisinin results in decreased expression of CD44 protein CTD PMID:39778717 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP artemisinin results in decreased expression of CDK4 protein CTD PMID:39778717 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,722...57,756,013 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
increases expression 		EXP
ISO 		artemisinin results in decreased activity of CYP1A2 protein
artemisinin results in increased expression of CYP1A2 mRNA 		CTD PMID:11124226 PMID:16919048 PMID:17962186 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,795...74,756,607 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases activity
increases expression 		ISO artemisinin results in increased activity of CYP2A5 protein
artemisinin results in increased expression of CYP2A5 mRNA 		CTD PMID:16919048 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,533...40,850,450 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases expression
increases activity
affects metabolic processing 		EXP
ISO 		[artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
artemisinin results in increased expression of CYP2B10 mRNA
artemisinin results in increased activity of CYP2B10 protein
artemisinin results in increased expression of CYP2B6 mRNA
CYP2B6 protein affects the metabolism of artemisinin 		CTD PMID:12920490 PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 More... NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,281...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP artemisinin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,662...94,856,282 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression ISO artemisinin results in increased expression of CYP2E1 mRNA CTD PMID:17962186 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
affects metabolic processing
increases expression 		EXP [artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of artemisinin
artemisinin results in increased expression of CYP3A4 mRNA 		CTD PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,959...99,784,274 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions ISO artemisinin inhibits the reaction [trimethyltin chloride results in decreased expression of DLG4 protein] CTD PMID:36696940 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836 		JBrowse link
G EPCAM epithelial cell adhesion molecule decreases expression EXP artemisinin results in decreased expression of EPCAM protein CTD PMID:39778717 NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 decreases expression EXP artemisinin results in decreased expression of ERBB2 protein CTD PMID:39778717 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ESRRA estrogen related receptor alpha multiple interactions EXP artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; artemisinin inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,080...64,316,744 		JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression ISO artemisinin results in decreased expression of FSHB protein CTD PMID:24876631 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases activity EXP artemisinin results in decreased activity of GSTA1 protein CTD PMID:11807801 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,881 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP artemisinin results in decreased activity of GSTP1 protein CTD PMID:11807801 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,658...67,586,659 		JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression EXP artemisinin results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL6 interleukin 6 increases expression EXP artemisinin results in increased expression of IL6 protein CTD PMID:39778717 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LYZ lysozyme multiple interactions EXP [parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein] CTD PMID:18463201 PMID:23355332 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,500,937...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein] CTD PMID:18463201 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP [artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; artemisinin binds to and results in increased activity of NR1I2 protein CTD PMID:15761118 PMID:17041008 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
increases expression
affects expression
affects localization
increases activity 		EXP
ISO 		[artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; artemisinin binds to and results in increased activity of NR1I3 protein; artemisinin binds to and results in increased activity of NR1I3 protein mutant form
artemisinin binds to and results in increased activity of NR1I3 protein; fenvalerate inhibits the reaction [artemisinin binds to and results in increased activity of NR1I3 protein]
artemisinin results in increased expression of NR1I3 mRNA
artemisinin affects the expression of NR1I3 mRNA alternative form
artemisinin affects the localization of NR1I3 protein
artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form
artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein mutant form 		CTD PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:20686338 More... NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,262 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PROK2 prokineticin 2 multiple interactions ISO artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of PROK2 protein] CTD PMID:36696940 NCBI chr 3:71,771,655...71,785,148
Ensembl chr 3:71,771,655...71,785,206 		JBrowse link
G PROKR2 prokineticin receptor 2 multiple interactions ISO artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of PROKR2 protein] CTD PMID:36696940 NCBI chr20:5,299,218...5,316,954
Ensembl chr20:5,299,218...5,316,954 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP artemisinin results in decreased expression of PTGS2 protein CTD PMID:39778717 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO 		artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of RELA protein]
artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of RELA protein] 		CTD PMID:18463201 PMID:23355332 PMID:36696940 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP artemisinin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,159,398 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP artemisinin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,676 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase increases expression EXP artemisinin results in increased expression of SRC protein CTD PMID:39778717 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,673...37,406,050 		JBrowse link
G SYN1 synapsin I multiple interactions ISO artemisinin inhibits the reaction [trimethyltin chloride results in decreased expression of SYN1 protein] CTD PMID:36696940 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,858 		JBrowse link
G SYP synaptophysin multiple interactions ISO artemisinin inhibits the reaction [trimethyltin chloride results in decreased expression of SYP protein] CTD PMID:36696940 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,807...49,200,218 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of TNF protein] CTD PMID:36696940 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 increases activity
increases expression 		EXP artemisinin results in increased activity of TP53 protein
artemisinin results in increased expression of TP53 protein 		CTD PMID:30818834 PMID:39778717 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
artemether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions EXP [Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA CTD PMID:31312845 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,281...41,018,398 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects expression
multiple interactions 		EXP artemether affects the expression of NR1I3 mRNA alternative form
[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; Artemether binds to and results in increased activity of NR1I3 protein alternative form 		CTD PMID:24721719 PMID:31312845 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,262 		JBrowse link
G PRL prolactin increases secretion ISO Artemether results in increased secretion of PRL protein CTD PMID:26811345 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
artemotil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects expression EXP artemotil affects the expression of NR1I3 mRNA alternative form CTD PMID:24721719 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,262 		JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression 		ISO
EXP 		Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein 		CTD PMID:30551460 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization EXP artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C multiple interactions
increases expression
increases response to substance 		EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]; APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein]; APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein]
Artesunate results in increased expression of APOBEC3C mRNA; Artesunate results in increased expression of APOBEC3C protein
APOBEC3C protein results in increased susceptibility to Artesunate 		CTD PMID:31664825 NCBI chr22:39,014,257...39,020,352
Ensembl chr22:39,014,224...39,020,352 		JBrowse link
G AR androgen receptor multiple interactions EXP artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,543,353...67,730,619 		JBrowse link
G ATG12 autophagy related 12 increases expression EXP Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr 5:115,828,200...115,841,565
Ensembl chr 5:115,828,200...115,841,837 		JBrowse link
G ATG3 autophagy related 3 increases expression EXP Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr 3:112,532,510...112,561,962
Ensembl chr 3:112,532,510...112,562,046 		JBrowse link
G ATG5 autophagy related 5 increases expression EXP Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,326,477 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		EXP
ISO 		Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein 		CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions 		EXP
ISO 		Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein 		CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BST1 bone marrow stromal cell antigen 1 increases response to substance EXP BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:15,703,065...15,774,173
Ensembl chr 4:15,703,000...15,775,614 		JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
increases cleavage 		EXP artesunate results in increased activity of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein] 		CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,695...184,650,418 		JBrowse link
G CASP9 caspase 9 affects expression EXP artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase increases expression
decreases response to substance 		EXP artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate 		CTD PMID:19513562 PMID:20144594 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,906...34,472,061 		JBrowse link
G CCND1 cyclin D1 decreases expression ISO Artesunate results in decreased expression of CCND1 protein CTD PMID:32633561 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,143...69,654,474 		JBrowse link
G CCNE1 cyclin E1 decreases expression ISO Artesunate results in decreased expression of CCNE1 protein CTD PMID:32633561 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,471...29,824,313 		JBrowse link
G CCT2 chaperonin containing TCP1 subunit 2 decreases response to substance EXP CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:69,585,459...69,601,570
Ensembl chr12:69,585,423...69,601,577 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression ISO Artesunate results in decreased expression of CDK2 protein CTD PMID:32633561 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression ISO Artesunate results in decreased expression of CDK4 protein CTD PMID:32633561 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,722...57,756,013 		JBrowse link
G CHEK1 checkpoint kinase 1 multiple interactions
increases phosphorylation 		EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
increases phosphorylation 		EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr22:28,687,742...28,741,834
Ensembl chr22:28,687,738...28,742,422 		JBrowse link
G CLIP4 CAP-Gly domain containing linker protein family member 4 increases response to substance EXP CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:29,097,726...29,183,808
Ensembl chr 2:29,095,545...29,199,777 		JBrowse link
G COQ8A coenzyme Q8A decreases response to substance EXP COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:226,940,294...226,987,544
Ensembl chr 1:226,938,143...226,987,569 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 affects metabolic processing EXP CYP2A6 protein affects the metabolism of artesunate CTD PMID:12920490 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,533...40,850,450 		JBrowse link
G DBH dopamine beta-hydroxylase increases response to substance EXP DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,314...133,659,329 		JBrowse link
G DES desmin multiple interactions
decreases expression 		EXP Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein 		CTD PMID:30551460 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,417,474...219,426,739 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,651,284...152,129,619 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FLNA filamin A increases response to substance EXP FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,638 		JBrowse link
G FN1 fibronectin 1 decreases expression
multiple interactions 		EXP Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] 		CTD PMID:30551460 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,120 		JBrowse link
G FTH1 ferritin heavy chain 1 decreases expression
multiple interactions 		EXP Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA] 		CTD PMID:30551460 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634 		JBrowse link
G FZD7 frizzled class receptor 7 increases response to substance EXP FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:202,033,855...202,038,441
Ensembl chr 2:202,033,855...202,038,441 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit affects response to substance
decreases response to substance 		EXP GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate 		CTD PMID:15796179 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases response to substance EXP GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,513 		JBrowse link
G GPX4 glutathione peroxidase 4 decreases activity
multiple interactions 		EXP
ISO 		Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] 		CTD PMID:30551460 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GSTM4 glutathione S-transferase mu 4 affects response to substance EXP GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases expression EXP artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,658...67,586,659 		JBrowse link
G GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) affects response to substance EXP GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr22:23,980,134...23,983,915
Ensembl chr22:23,980,058...23,983,915 		JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 affects response to substance EXP GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597 		JBrowse link
G H2AX H2A.X variant histone multiple interactions
increases phosphorylation 		EXP APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGB1 integrin subunit beta 1 increases response to substance EXP ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases lipidation 		EXP 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,405,090 		JBrowse link
G MGST3 microsomal glutathione S-transferase 3 affects response to substance EXP MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:165,631,234...165,656,136
Ensembl chr 1:165,630,874...165,661,796 		JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,448 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression 		ISO
EXP 		artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Artesunate results in decreased expression of MMP9 mRNA
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA] 		CTD PMID:29031619 PMID:30551460 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance EXP MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation 		EXP acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,531...11,262,556 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G NACA nascent polypeptide associated complex subunit alpha decreases response to substance EXP NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:56,712,427...56,725,299
Ensembl chr12:56,712,305...56,731,628 		JBrowse link
G NCKAP1 NCK associated protein 1 increases response to substance EXP NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:182,909,115...183,038,457
Ensembl chr 2:182,909,115...183,038,858 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 multiple interactions
decreases expression 		EXP Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein 		CTD PMID:30551460 NCBI chr10:46,005,088...46,030,623
Ensembl chr10:46,005,085...46,030,669 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects localization EXP artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,668 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions 		EXP Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] 		CTD PMID:24704559 PMID:33002460 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PGR progesterone receptor multiple interactions EXP artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RPA2 replication protein A2 increases phosphorylation EXP Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746 		JBrowse link
G RPL29P2 ribosomal protein L29 pseudogene 2 decreases response to substance EXP RPL29P2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:7,754,320...7,754,976
Ensembl chr17:7,754,394...7,754,853
Ensembl chr17:7,754,394...7,754,853 		JBrowse link
G RPL41 ribosomal protein L41 decreases response to substance EXP RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:56,116,633...56,117,967
Ensembl chr12:56,116,590...56,117,967 		JBrowse link
G RPL6 ribosomal protein L6 decreases response to substance EXP RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:112,405,181...112,418,835
Ensembl chr12:112,405,170...112,418,844 		JBrowse link
G RPL7 ribosomal protein L7 decreases response to substance EXP RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 8:73,290,242...73,294,466
Ensembl chr 8:73,290,242...73,295,789 		JBrowse link
G RPS12 ribosomal protein S12 decreases response to substance EXP RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:132,814,569...132,817,564
Ensembl chr 6:132,814,557...132,817,577 		JBrowse link
G RPS15A ribosomal protein S15a decreases response to substance EXP RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr16:18,781,295...18,790,334
Ensembl chr16:18,781,295...18,790,383 		JBrowse link
G RPS6 ribosomal protein S6 decreases response to substance EXP RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,282 		JBrowse link
G SLC25A19 solute carrier family 25 member 19 decreases response to substance EXP SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:75,272,992...75,289,433
Ensembl chr17:75,272,012...75,289,968 		JBrowse link
G SP1 Sp1 transcription factor decreases expression EXP artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression 		EXP Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein 		CTD PMID:30551460 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SRSF2 serine and arginine rich splicing factor 2 decreases response to substance EXP SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:76,734,115...76,737,411
Ensembl chr17:76,734,115...76,737,395 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression 		EXP Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] CTD PMID:30551460 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression 		EXP Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
Artesunate results in increased expression of TP53 protein 		CTD PMID:33259807 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TPT1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions 		EXP TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] 		CTD PMID:15878303 PMID:33259807 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284 		JBrowse link
G TUFM Tu translation elongation factor, mitochondrial decreases response to substance EXP TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,410...28,846,419 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions 		EXP Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein] 		CTD PMID:33002460 NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,621...131,923,161 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G YY1 YY1 transcription factor decreases expression EXP artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr14:100,239,144...100,282,788
Ensembl chr14:100,238,298...100,282,788 		JBrowse link
G ZBTB4 zinc finger and BTB domain containing 4 increases response to substance EXP ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:7,459,378...7,484,249
Ensembl chr17:7,459,366...7,484,263 		JBrowse link
ascaridole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC6 ERCC excision repair 6, chromatin remodeling factor affects response to substance EXP ERCC6 protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538 		JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor affects response to substance EXP XPC protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr 3:14,145,147...14,178,601
Ensembl chr 3:14,145,145...14,178,652 		JBrowse link
carbon dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases expression
multiple interactions 		ISO Carbon Dioxide results in increased expression of AKT1 protein
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of AKT1 protein] 		CTD PMID:37661366 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,348...104,799,934 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions 		ISO Carbon Dioxide results in increased expression of BCL2 protein
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of BCL2 protein] 		CTD PMID:37661366 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions
increases secretion 		ISO Carbon Dioxide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein]
Carbon Dioxide results in increased secretion of CALCA protein 		CTD PMID:18052948 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,209,993...44,334,577 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CRH corticotropin releasing hormone increases response to substance EXP CRH protein results in increased susceptibility to Carbon Dioxide CTD PMID:8957205 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G DLG3 discs large MAGUK scaffold protein 3 multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:70,444,835...70,505,490
Ensembl chr  X:70,444,835...70,505,490 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] CTD PMID:24718106 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G IL2 interleukin 2 increases expression
multiple interactions 		EXP
ISO 		Carbon Dioxide results in increased expression of IL2 protein
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 mRNA]; 3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 protein]
Carbon Dioxide results in increased expression of IL2 mRNA; Carbon Dioxide results in increased expression of IL2 protein 		CTD PMID:37661366 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein] CTD PMID:24718106 PMID:25004876 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,755,537...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein] CTD PMID:24718106 PMID:25004876 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MIR29A microRNA 29a multiple interactions EXP [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which results in increased expression of MIR29A mRNA CTD PMID:29980036 NCBI chr 7:130,876,747...130,876,810
Ensembl chr 7:130,876,747...130,876,810 		JBrowse link
G NEIL1 nei like DNA glycosylase 1 affects abundance ISO NEIL1 affects the abundance of Carbon Dioxide CTD PMID:21285402 NCBI chr15:75,347,039...75,357,115
Ensembl chr15:75,346,878...75,357,115 		JBrowse link
G NGB neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein] CTD PMID:16684569 NCBI chr14:77,265,483...77,271,206
Ensembl chr14:77,265,483...77,271,206 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Carbon Dioxide] CTD PMID:21324916 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,149,924...46,243,755 		JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 multiple interactions ISO [RAPGEF3 protein affects the susceptibility to Dietary Fats] which affects the chemical synthesis of Carbon Dioxide CTD PMID:27381457 NCBI chr12:47,734,363...47,758,880
Ensembl chr12:47,734,363...47,771,040 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 affects response to substance ISO SLC9A1 protein affects the susceptibility to Carbon Dioxide CTD PMID:16831598 NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide]; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide] CTD PMID:19243126 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,633...31,668,931 		JBrowse link
G SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein multiple interactions EXP [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which affects the expression of SYNCRIP mRNA CTD PMID:29980036 NCBI chr 6:85,607,784...85,643,870
Ensembl chr 6:85,607,779...85,644,063 		JBrowse link
G SYNGAP1 synaptic Ras GTPase activating protein 1 multiple interactions ISO [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr 6:33,418,167...33,453,689
Ensembl chr 6:33,419,661...33,453,689 		JBrowse link
G TPI1 triosephosphate isomerase 1 increases expression ISO Carbon Dioxide results in increased expression of TPI1 mRNA CTD PMID:14762718 NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948 		JBrowse link
G TRH thyrotropin releasing hormone increases response to substance EXP TRH protein results in increased susceptibility to Carbon Dioxide CTD PMID:8957205 NCBI chr 3:129,974,720...129,977,935
Ensembl chr 3:129,974,688...129,977,935 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 increases activity ISO Carbon Dioxide results in increased activity of TRPA1 protein CTD PMID:20881114 NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,608...72,089,998 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 affects response to substance ISO TRPV1 protein affects the susceptibility to Carbon Dioxide CTD PMID:16831598 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411 		JBrowse link
carbon monoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases activity ISO Carbon Monoxide results in increased activity of ABCC2 protein CTD PMID:13678533 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases expression 		ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein 		CTD PMID:19356108 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ADM adrenomedullin increases expression ISO Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein CTD PMID:10666155 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,303,392...10,307,397 		JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA CTD PMID:29621558 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,387...16,833,433 		JBrowse link
G AGT angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to Carbon Monoxide CTD PMID:18174886 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		ISO
EXP 		AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein] 		CTD PMID:17179207 PMID:18037988 PMID:18215737 PMID:18845810 PMID:19356108 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,348...104,799,934 		JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions
increases activity 		ISO Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]
Carbon Monoxide results in increased activity of ALAD protein 		CTD PMID:1032310 PMID:6740708 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,304...113,401,356 		JBrowse link
G AREG amphiregulin multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA CTD PMID:29621558 NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,444,999...74,455,005 		JBrowse link
G BACH1 BTB domain and CNC homolog 1 decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of BACH1 protein CTD PMID:18845810 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751 		JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:18037988 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,828...64,291,946 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
decreases expression 		ISO Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein
Carbon Monoxide results in decreased expression of BDNF mRNA 		CTD PMID:27113706 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions EXP BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity 		ISO
EXP 		[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP3 mRNA]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
Carbon Monoxide results in increased expression of CASP3 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA
Carbon Monoxide results in increased activity of CASP3 protein 		CTD PMID:17173083 PMID:19356108 PMID:19520142 PMID:25562542 PMID:31268311 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,695...184,650,418 		JBrowse link
G CASP7 caspase 7 increases activity ISO Carbon Monoxide results in increased activity of CASP7 protein CTD PMID:25562542 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,731,290 		JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions 		ISO
EXP 		Carbon Monoxide results in increased activity of CASP8 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA 		CTD PMID:25562542 PMID:31268311 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions
increases expression 		ISO
EXP 		Carbon Monoxide results in increased activity of CASP9 protein
sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 mRNA]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 protein]
Carbon Monoxide results in increased expression of CASP9 mRNA; Carbon Monoxide results in increased expression of CASP9 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA 		CTD PMID:25562542 PMID:31268311 PMID:37860845 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
decreases expression 		ISO CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide results in decreased expression of CAT protein
CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein] 		CTD PMID:17179207 PMID:18845810 PMID:34032369 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,906...34,472,061 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA CTD PMID:29621558 NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233 		JBrowse link
G CD86 CD86 molecule decreases expression ISO Carbon Monoxide results in decreased expression of CD86 protein CTD PMID:12201358 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G CLCA1 chloride channel accessory 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA CTD PMID:29621558 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,501,400 		JBrowse link
G COL11A1 collagen type XI alpha 1 chain multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA CTD PMID:29621558 NCBI chr 1:102,876,473...103,108,522
Ensembl chr 1:102,876,467...103,108,872 		JBrowse link
G CRP C-reactive protein increases expression EXP Carbon Monoxide results in increased expression of CRP protein CTD PMID:18629312 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA CTD PMID:29621558 NCBI chr 4:76,033,682...76,036,070
Ensembl chr 4:76,033,682...76,041,415 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions ISO Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA] CTD PMID:10581206 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity
multiple interactions 		EXP
ISO 		Carbon Monoxide results in decreased activity of CYP2E1 protein
Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)] 		CTD PMID:1903091 PMID:15036350 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DNM1L dynamin 1 like increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of DNM1L protein
sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of DNM1L protein] 		CTD PMID:37860845 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650 		JBrowse link
G DUOX2 dual oxidase 2 decreases expression
increases expression 		ISO Carbon Monoxide results in decreased expression of DUOX2 protein
Carbon Monoxide results in increased expression of DUOX2 mRNA 		CTD PMID:29223502 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172 		JBrowse link
G EDN1 endothelin 1 increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein] 		CTD PMID:11781074 PMID:12969895 PMID:20197249 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,287,459...12,297,194 		JBrowse link
G EGR1 early growth response 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]] CTD PMID:22046279 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G ENO2 enolase 2 increases secretion EXP Carbon Monoxide results in increased secretion of ENO2 protein CTD PMID:34533065 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,707 		JBrowse link
G EPO erythropoietin increases expression ISO Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein CTD PMID:9263988 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Carbon Monoxide results in increased expression of ERO1A mRNA CTD PMID:12752442 NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,696,025 		JBrowse link
G EZR ezrin multiple interactions EXP [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in decreased expression of EZR protein CTD PMID:37141245 NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,413 		JBrowse link
G FGB fibrinogen beta chain multiple interactions EXP FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:19750100 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,562,971...154,572,807 		JBrowse link
G FOXP3 forkhead box P3 multiple interactions EXP [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of FOXP3 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 PMID:33603036 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,436...49,264,800 		JBrowse link
G GABPA GA binding protein transcription factor subunit alpha increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of GABPA mRNA
Carbon Monoxide results in increased expression of GABPA protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter] 		CTD PMID:17179207 NCBI chr21:25,734,972...25,772,460
Ensembl chr21:25,734,570...25,772,460 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein] CTD PMID:18037988 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,785...11,760,002 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression 		ISO [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA
Carbon Monoxide results in increased expression of GCLC mRNA 		CTD PMID:34032369 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GPR182 G protein-coupled receptor 182 increases expression ISO Carbon Monoxide results in increased expression of GPR182 mRNA CTD PMID:10666155 NCBI chr12:56,994,492...56,998,877
Ensembl chr12:56,994,492...56,998,889 		JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation 		ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]
Carbon Monoxide results in increased phosphorylation of GSK3B protein 		CTD PMID:18037988 PMID:18845810 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
increases activity 		ISO
EXP 		Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased chemical synthesis of Carbon Monoxide
[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein] 		CTD PMID:11880364 PMID:16365149 PMID:18037988 PMID:18845810 PMID:19520142 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HMOX2 heme oxygenase 2 multiple interactions
affects chemical synthesis
affects abundance 		ISO Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
HMOX2 protein affects the chemical synthesis of Carbon Monoxide
HMOX2 protein affects the abundance of Carbon Monoxide 		CTD PMID:11342580 PMID:12969895 NCBI chr16:4,474,736...4,510,347
Ensembl chr16:4,474,246...4,510,352 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO
EXP 		[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] 		CTD PMID:19356108 PMID:19608869 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions ISO
EXP 		[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IFNG gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IFNG gene 		CTD PMID:16365149 PMID:29621558 PMID:33603036 PMID:35287715 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 multiple interactions EXP [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IGF2BP1 gene CTD PMID:35999615 NCBI chr17:48,996,558...49,056,145
Ensembl chr17:48,997,225...49,056,145 		JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression 		ISO
EXP 		Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL10 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IL10 gene
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]]
Carbon Monoxide results in increased expression of IL10 mRNA 		CTD PMID:21444764 PMID:31732924 PMID:33603036 PMID:35287715 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] CTD PMID:16365149 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL13 interleukin 13 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA CTD PMID:29621558 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL17A interleukin 17A multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein CTD PMID:29621558 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL18 interleukin 18 decreases response to substance
multiple interactions 		EXP Carbon Monoxide results in decreased susceptibility to IL18 protein
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] 		CTD PMID:18215737 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,106 		JBrowse link
G IL1B interleukin 1 beta decreases expression
increases expression
multiple interactions 		ISO Carbon Monoxide results in decreased expression of IL1B protein
Carbon Monoxide results in increased expression of IL1B protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]] 		CTD PMID:21444764 PMID:31732924 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of IL1RL1 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]] 		CTD PMID:31732924 NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,353 		JBrowse link
G IL22 interleukin 22 increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of IL22 mRNA
HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased expression of IL22 mRNA] 		CTD PMID:21444764 NCBI chr12:68,248,242...68,253,604
Ensembl chr12:68,248,242...68,253,604 		JBrowse link
G IL33 interleukin 33 increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of IL33 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]] 		CTD PMID:31732924 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,136...6,257,983 		JBrowse link
G IL4 interleukin 4 decreases expression
multiple interactions 		ISO
EXP 		Carbon Monoxide results in decreased expression of IL4 protein
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL4 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IL4 gene
[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein; iodopravadoline inhibits the reaction [[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein]
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein 		CTD PMID:21444764 PMID:29621558 PMID:31732924 PMID:33603036 PMID:35287715 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression 		EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:18629312 PMID:19608869 PMID:19750100 PMID:31268311 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF8 interferon regulatory factor 8 decreases activity ISO Carbon Monoxide results in decreased activity of IRF8 protein CTD PMID:16365149 NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,116...85,922,606 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,119...10,503,558 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,738...36,122,511 		JBrowse link
G MBP myelin basic protein affects response to substance EXP MBP polymorphism affects the susceptibility to Carbon Monoxide CTD PMID:36481359 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683 		JBrowse link
G MFN2 mitofusin 2 multiple interactions
decreases expression 		ISO sulforaphane affects the reaction [Carbon Monoxide results in decreased expression of MFN2 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of MFN2 mRNA]
Carbon Monoxide results in decreased expression of MFN2 mRNA; Carbon Monoxide results in decreased expression of MFN2 protein 		CTD PMID:37860845 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MIR1224 microRNA 1224 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA CTD PMID:31268311 NCBI chr 3:184,241,405...184,241,489
Ensembl chr 3:184,241,405...184,241,489 		JBrowse link
G MIR186 microRNA 186 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA CTD PMID:31268311 NCBI chr 1:71,067,631...71,067,716
Ensembl chr 1:71,067,631...71,067,716 		JBrowse link
G MIR197 microRNA 197 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR197 mRNA CTD PMID:31268311 NCBI chr 1:109,598,893...109,598,967
Ensembl chr 1:109,598,893...109,598,967 		JBrowse link
G MIR21 microRNA 21 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA CTD PMID:31268311 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR2861 microRNA 2861 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR2861 mRNA CTD PMID:31268311 NCBI chr 9:127,785,918...127,786,007
Ensembl chr 9:127,785,918...127,786,007 		JBrowse link
G MIR342 microRNA 342 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA CTD PMID:31268311 NCBI chr14:100,109,655...100,109,753
Ensembl chr14:100,109,655...100,109,753 		JBrowse link
G MIR3654 microRNA 3654 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR3654 mRNA CTD PMID:31268311 NCBI chr 7:133,034,860...133,034,915
Ensembl chr 7:133,034,860...133,034,915 		JBrowse link
G MIR374B microRNA 374b multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA CTD PMID:31268311 NCBI chr  X:74,218,547...74,218,618
Ensembl chr  X:74,218,547...74,218,618 		JBrowse link
G MIR615 microRNA 615 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA CTD PMID:31268311 NCBI chr12:54,033,950...54,034,045
Ensembl chr12:54,033,950...54,034,045 		JBrowse link
G MIR6722 microRNA 6722 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR6722 mRNA CTD PMID:31268311 NCBI chr 9:136,746,893...136,746,970
Ensembl chr 9:136,746,893...136,746,970 		JBrowse link
G MIR93 microRNA 93 multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA CTD PMID:31268311 NCBI chr 7:100,093,768...100,093,847
Ensembl chr 7:100,093,768...100,093,847 		JBrowse link
G MIRLET7E microRNA let-7e multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7E mRNA CTD PMID:31268311 NCBI chr19:51,692,786...51,692,864
Ensembl chr19:51,692,786...51,692,864 		JBrowse link
G MIRLET7I microRNA let-7i multiple interactions EXP [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA CTD PMID:31268311 NCBI chr12:62,603,686...62,603,769
Ensembl chr12:62,603,686...62,603,769 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression ISO Carbon Monoxide results in increased expression of MMP9 mRNA CTD PMID:20197249 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions ISO [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein; iodopravadoline inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein] CTD PMID:31732924 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,014...17,911,164 		JBrowse link
G NDRG1 N-myc downstream regulated 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein] CTD PMID:11006124 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases localization
decreases phosphorylation 		ISO Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of NFE2L2 mRNA; Carbon Monoxide results in increased expression of NFE2L2 protein
[NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]; NFE2L2 protein promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 mRNA]
Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein 		CTD PMID:18845810 PMID:25348283 PMID:34032369 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NGF nerve growth factor affects expression
multiple interactions 		ISO Carbon Monoxide affects the expression of NGF mRNA
Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein 		CTD PMID:27113706 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression 		ISO Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Carbon Monoxide results in decreased expression of NOS2 protein 		CTD PMID:12201358 PMID:22046279 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,758 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein CTD PMID:19356108 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,015,653 		JBrowse link
G NPPA natriuretic peptide A increases expression ISO Carbon Monoxide results in increased expression of NPPA mRNA CTD PMID:11781074 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions
increases expression
increases localization 		ISO AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]
Carbon Monoxide results in increased expression of NRF1 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
Carbon Monoxide results in increased expression of NRF1 mRNA 		CTD PMID:17179207 PMID:18845810 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,699...129,757,082 		JBrowse link
G NTF3 neurotrophin 3 decreases expression
multiple interactions 		ISO Carbon Monoxide results in decreased expression of NTF3 mRNA
Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein 		CTD PMID:27113706 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 increases expression ISO [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein CTD PMID:19356108 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PLA2G7 phospholipase A2 group VII affects expression EXP Carbon Monoxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,718 		JBrowse link
G POLG DNA polymerase gamma, catalytic subunit increases expression ISO Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein CTD PMID:17179207 NCBI chr15:89,316,320...89,334,824
Ensembl chr15:89,305,198...89,334,861 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:22046279 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,574 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of PPARGC1A mRNA
Carbon Monoxide results in increased expression of PPARGC1A protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein] 		CTD PMID:17179207 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRG2 proteoglycan 2, pro eosinophil major basic protein multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA CTD PMID:29621558 NCBI chr11:57,386,780...57,390,650
Ensembl chr11:57,386,780...57,391,143 		JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 decreases expression
multiple interactions 		ISO Carbon Monoxide results in decreased expression of PRKAA2 mRNA
sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of PRKAA2 mRNA] 		CTD PMID:37860845 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335 		JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit multiple interactions EXP [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SELP selectin P increases expression EXP Carbon Monoxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,421...169,630,193 		JBrowse link
G SFTPD surfactant protein D multiple interactions EXP [[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in increased expression of SFTPD protein CTD PMID:37141245 NCBI chr10:79,937,740...79,982,383
Ensembl chr10:79,937,128...79,983,996 		JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP Carbon Monoxide results in decreased expression of SOD1 protein CTD PMID:18629312 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,633...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases expression 		ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of SOD2 protein 		CTD PMID:17179207 PMID:18037988 PMID:18845810 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOSTDC1 sclerostin domain containing 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA CTD PMID:29621558 NCBI chr 7:16,461,481...16,465,738
Ensembl chr 7:16,461,481...16,530,580 		JBrowse link
G TFAM transcription factor A, mitochondrial increases expression
multiple interactions 		ISO Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]] 		CTD PMID:17179207 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
decreases expression
decreases response to substance 		ISO
EXP 		(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]]
Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
Carbon Monoxide results in decreased susceptibility to TNF protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in decreased expression of TNF protein 		CTD
RGD		 PMID:11880364 PMID:17173083 PMID:19356108 PMID:19608869 PMID:21444764 More... RGD:15023490 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B increases expression EXP Carbon Monoxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,977...12,209,228 		JBrowse link
G TNFSF4 TNF superfamily member 4 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA CTD PMID:29621558 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,162,645...173,477,583 		JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] CTD PMID:22046279 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,983,542 		JBrowse link
G VASP vasodilator stimulated phosphoprotein decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of VASP protein CTD PMID:26582457 NCBI chr19:45,507,479...45,526,983
Ensembl chr19:45,506,579...45,526,991 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO 		Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] 		CTD PMID:19356108 PMID:19608869 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,684...100,739,045 		JBrowse link
G XDH xanthine dehydrogenase increases activity
increases metabolic processing 		ISO Carbon Monoxide results in increased activity of XDH protein
Carbon Monoxide results in increased metabolism of XDH protein 		CTD PMID:1447108 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,320...31,414,747 		JBrowse link
ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,695...184,650,418 		JBrowse link
prostaglandin G2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1 member C1 increases metabolic processing EXP AKR1C1 protein results in increased metabolism of prostaglandin G2 CTD PMID:8573067 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases abundance 		ISO [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] CTD PMID:12538810 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
prostaglandin H2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTM2 glutathione S-transferase mu 2 affects metabolic processing EXP GSTM2 protein affects the metabolism of Prostaglandin H2 CTD PMID:10905636 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,667,348...109,709,551 		JBrowse link
G GSTM3 glutathione S-transferase mu 3 affects metabolic processing EXP GSTM3 protein affects the metabolism of Prostaglandin H2 CTD PMID:10905636 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038 		JBrowse link
G PTGDS prostaglandin D2 synthase increases metabolic processing ISO PTGDS protein results in increased metabolism of Prostaglandin H2 CTD PMID:22043816 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,053...136,981,750 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26866
    chemical entity 26846
      molecular entity 26828
        polyatomic entity 26594
          heteroatomic molecular entity 25814
            oxide 14410
              organic oxide 239
                carbon oxide + 133
                organic peroxide + 121
Path 2
Term Annotations click to browse term
  CHEBI ontology 26866
    subatomic particle 26844
      composite particle 26844
        hadron 26842
          baryon 26844
            nucleon 26842
              atomic nucleus 26844
                atom 26842
                  main group element atom 26592
                    main group molecular entity 26595
                      p-block molecular entity 26587
                        carbon group molecular entity 26076
                          organic molecular entity 26011
                            organic molecule 25631
                              organic oxide 239
                                carbon oxide + 133
                                organic peroxide + 121
paths to the root