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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression decreases activity |
ISO |
artemisinin results in increased expression of ABCB1 mRNA artemisinin results in decreased activity of ABCB1 protein |
CTD |
PMID:15761118 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] |
CTD |
PMID:18463201 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Casp3 |
caspase 3 |
increases activity |
EXP |
artemisinin results in increased activity of CASP3 protein |
CTD |
PMID:17948936 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
decreases activity |
EXP |
artemisinin results in decreased activity of CAT protein |
CTD |
PMID:24876631 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] |
CTD |
PMID:18463201 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases expression |
ISO EXP |
artemisinin results in decreased activity of CYP1A2 protein artemisinin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:11124226 PMID:16919048 PMID:17962186 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
artemisinin results in increased expression of CYP2B1 mRNA |
CTD |
PMID:16919048 PMID:36356836 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions increases expression increases activity affects metabolic processing |
ISO |
[artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA artemisinin results in increased expression of CYP2B10 mRNA artemisinin results in increased activity of CYP2B10 protein CYP2B6 protein affects the metabolism of artemisinin artemisinin results in increased expression of CYP2B6 mRNA |
CTD |
PMID:12920490 PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:18332078 More...
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
artemisinin results in decreased activity of CYP2C19 protein |
CTD |
PMID:11124226 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
ISO |
artemisinin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:17962186 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions affects metabolic processing increases expression |
ISO |
[artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CYP3A4 protein affects the metabolism of artemisinin artemisinin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:12920490 PMID:15761118 PMID:17041008 PMID:18332078 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [trimethyltin chloride results in decreased expression of DLG4 protein] |
CTD |
PMID:36696940 |
|
NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Esrra |
estrogen related receptor, alpha |
multiple interactions |
ISO |
artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; artemisinin inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] |
CTD |
PMID:30818834 |
|
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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G |
Fshb |
follicle stimulating hormone subunit beta |
decreases expression |
EXP |
artemisinin results in decreased expression of FSHB protein |
CTD |
PMID:24876631 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases activity |
ISO |
artemisinin results in decreased activity of GSTA1 protein |
CTD |
PMID:11807801 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity |
ISO |
artemisinin results in decreased activity of GSTP1 protein |
CTD |
PMID:11807801 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Idh3a |
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha |
decreases expression |
ISO |
artemisinin results in decreased expression of IDH3A mRNA |
CTD |
PMID:30818834 |
|
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:18463201 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Lyz2 |
lysozyme 2 |
multiple interactions |
ISO |
[parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] |
CTD |
PMID:23355332 |
|
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein] |
CTD |
PMID:18463201 PMID:23355332 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18463201 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
[artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; artemisinin binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:15761118 PMID:17041008 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions increases expression affects expression affects localization increases activity |
ISO EXP |
[artemisinin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; artemisinin binds to and results in increased activity of NR1I3 protein; artemisinin binds to and results in increased activity of NR1I3 protein mutant form artemisinin binds to and results in increased activity of NR1I3 protein; fenvalerate inhibits the reaction [artemisinin binds to and results in increased activity of NR1I3 protein] artemisinin results in increased expression of NR1I3 mRNA artemisinin affects the expression of NR1I3 mRNA alternative form artemisinin affects the localization of NR1I3 protein artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein mutant form |
CTD |
PMID:15761118 PMID:16919048 PMID:17041008 PMID:17962186 PMID:20686338 PMID:21778469 PMID:24721719 PMID:27665777 PMID:27732639 PMID:31472229 PMID:31538121 More...
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] |
CTD |
PMID:30818834 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prok2 |
prokineticin 2 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of PROK2 protein] |
CTD |
PMID:36696940 |
|
NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385
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G |
Prokr2 |
prokineticin receptor 2 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of PROKR2 protein] |
CTD |
PMID:36696940 |
|
NCBI chr 3:119,624,738...119,639,442
Ensembl chr 3:119,627,601...119,635,718
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
artemisinin inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of RELA protein] artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of RELA protein] |
CTD |
PMID:18463201 PMID:23355332 PMID:36696940 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:27504015 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:27504015 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:27504015 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
artemisinin inhibits the reaction [trimethyltin chloride results in decreased expression of SYN1 protein] |
CTD |
PMID:36696940 |
|
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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G |
Syp |
synaptophysin |
multiple interactions |
ISO |
artemisinin inhibits the reaction [trimethyltin chloride results in decreased expression of SYP protein] |
CTD |
PMID:36696940 |
|
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
artemisinin inhibits the reaction [trimethyltin chloride results in increased expression of TNF protein] |
CTD |
PMID:36696940 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases activity |
ISO |
artemisinin results in increased activity of TP53 protein |
CTD |
PMID:30818834 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA |
CTD |
PMID:31312845 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects expression multiple interactions |
ISO |
artemether affects the expression of NR1I3 mRNA alternative form [Artemether co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; Artemether binds to and results in increased activity of NR1I3 protein alternative form |
CTD |
PMID:24721719 PMID:31312845 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Prl |
prolactin |
increases secretion |
EXP |
Artemether results in increased secretion of PRL protein |
CTD |
PMID:26811345 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects expression |
ISO |
artemotil affects the expression of NR1I3 mRNA alternative form |
CTD |
PMID:24721719 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA] Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:30551460 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization |
ISO |
artesunate affects the localization of AIFM1 protein |
CTD |
PMID:24704559 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Atg12 |
autophagy related 12 |
increases expression |
ISO |
Artesunate results in increased expression of ATG12 mRNA |
CTD |
PMID:30551460 |
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NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg3 |
autophagy related 3 |
increases expression |
ISO |
Artesunate results in increased expression of ATG3 mRNA |
CTD |
PMID:30551460 |
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NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
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G |
Atg5 |
autophagy related 5 |
increases expression |
ISO |
Artesunate results in increased expression of ATG5 mRNA |
CTD |
PMID:30551460 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
Artesunate results in increased expression of BAX protein [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein |
CTD |
PMID:24704559 PMID:29031619 PMID:33002460 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Artesunate results in decreased expression of BCL2 protein [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein] |
CTD |
PMID:24704559 PMID:29031619 PMID:33002460 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bst1 |
bone marrow stromal cell antigen 1 |
increases response to substance |
ISO |
BST1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
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G |
Casp3 |
caspase 3 |
increases activity increases cleavage multiple interactions |
ISO |
artesunate results in increased activity of CASP3 protein Artesunate results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein] |
CTD |
PMID:19513562 PMID:24704559 PMID:33002460 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
affects expression |
ISO |
artesunate affects the expression of CASP9 protein |
CTD |
PMID:24704559 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
increases expression decreases response to substance |
ISO |
artesunate results in increased expression of CAT protein CAT protein results in decreased susceptibility to artesunate |
CTD |
PMID:19513562 PMID:20144594 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cct2 |
chaperonin containing TCP1 subunit 2 |
decreases response to substance |
ISO |
CCT2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
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G |
Chek1 |
checkpoint kinase 1 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] |
CTD |
PMID:31664825 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] |
CTD |
PMID:31664825 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
increases response to substance |
ISO |
CLIP4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 6:23,616,280...23,697,625 NCBI chr 6:23,718,580...23,729,231 NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874
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G |
Coq8a |
coenzyme Q8A |
decreases response to substance |
ISO |
COQ8A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] |
CTD |
PMID:29031619 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Dbh |
dopamine beta-hydroxylase |
increases response to substance |
ISO |
DBH mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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G |
Des |
desmin |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA] Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein |
CTD |
PMID:30551460 |
|
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
artesunate binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:25752796 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
artesunate results in increased expression of FAS protein |
CTD |
PMID:19513562 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Flna |
filamin A |
increases response to substance |
ISO |
FLNA mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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G |
Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO |
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein |
CTD |
PMID:30551460 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fth1 |
ferritin heavy chain 1 |
decreases expression multiple interactions |
ISO |
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA] |
CTD |
PMID:30551460 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Fzd7 |
frizzled class receptor 7 |
increases response to substance |
ISO |
FZD7 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
affects response to substance decreases response to substance |
ISO |
GCLC mRNA affects the susceptibility to artesunate GCLC mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
decreases response to substance |
ISO |
GCLM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases activity multiple interactions |
ISO |
Artesunate results in decreased activity of GPX4 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] |
CTD |
PMID:30551460 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gstm4 |
glutathione S-transferase mu 4 |
affects response to substance |
ISO |
GSTM4 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
artesunate results in decreased expression of GSTP1 protein |
CTD |
PMID:19513562 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt2 |
glutathione S-transferase theta 2 |
affects response to substance |
ISO |
GSTT2 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects response to substance |
ISO |
GSTZ1 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] |
CTD |
PMID:31664825 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb1 |
integrin subunit beta 1 |
increases response to substance |
ISO |
ITGB1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases lipidation |
ISO |
3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:33002460 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mgst3 |
microsomal glutathione S-transferase 3 |
affects response to substance |
ISO |
MGST3 mRNA affects the susceptibility to artesunate |
CTD |
PMID:15796179 |
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NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] |
CTD |
PMID:29031619 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
EXP ISO |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA] |
CTD |
PMID:29031619 PMID:30551460 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:27474069 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
decreases response to substance |
ISO |
MTHFD2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:33002460 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] |
CTD |
PMID:30031708 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Naca |
nascent polypeptide associated complex subunit alpha |
decreases response to substance |
ISO |
NACA mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
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G |
Nckap1 |
NCK-associated protein 1 |
increases response to substance |
ISO |
NCKAP1 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
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G |
Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA] Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein |
CTD |
PMID:30551460 |
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NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
artesunate affects the localization of NFE2L2 protein |
CTD |
PMID:26340163 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] |
CTD |
PMID:30031708 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
Artesunate results in increased cleavage of PARP1 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] |
CTD |
PMID:24704559 PMID:33002460 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] |
CTD |
PMID:29031619 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
artesunate binds to and results in increased activity of PGR protein |
CTD |
PMID:25752796 |
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein |
CTD |
PMID:30551460 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rpa2 |
replication protein A2 |
increases phosphorylation |
ISO |
Artesunate results in increased phosphorylation of RPA2 protein |
CTD |
PMID:31664825 |
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NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
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G |
Rpl41 |
ribosomal protein L41 |
decreases response to substance |
ISO |
RPL41 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 7:977,885...978,965
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G |
Rpl6 |
ribosomal protein L6 |
decreases response to substance |
ISO |
RPL6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
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G |
Rpl7 |
ribosomal protein L7 |
decreases response to substance |
ISO |
RPL7 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr 5:3,217,184...3,220,192
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G |
Rps12 |
ribosomal protein S12 |
decreases response to substance |
ISO |
RPS12 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
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G |
Rps15a |
ribosomal protein S15a |
decreases response to substance |
ISO |
RPS15A mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
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G |
Rps6 |
ribosomal protein S6 |
decreases response to substance |
ISO |
RPS6 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Slc25a19 |
solute carrier family 25 member 19 |
decreases response to substance |
ISO |
SLC25A19 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
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G |
Sp1 |
Sp1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of SP1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein] Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein |
CTD |
PMID:30551460 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
decreases response to substance |
ISO |
SRSF2 mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
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NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] |
CTD |
PMID:30551460 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] |
CTD |
PMID:30031708 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] |
CTD |
PMID:27474069 PMID:30031708 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
Artesunate results in increased expression of TP53 protein Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] |
CTD |
PMID:33259807 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpt1 |
tumor protein, translationally-controlled 1 |
affects response to substance multiple interactions |
ISO |
TPT1 protein affects the susceptibility to artesunate Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein] |
CTD |
PMID:15878303 PMID:33259807 |
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NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
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G |
Tufm |
Tu translation elongation factor, mitochondrial |
decreases response to substance |
ISO |
TUFM mRNA results in decreased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
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G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Artesunate results in increased phosphorylation of ULK1 protein acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein] |
CTD |
PMID:33002460 |
|
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] |
CTD |
PMID:29031619 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Yy1 |
YY1 transcription factor |
decreases expression |
ISO |
artesunate results in decreased expression of YY1 protein |
CTD |
PMID:19513562 |
|
NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
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G |
Zbtb4 |
zinc finger and BTB domain containing 4 |
increases response to substance |
ISO |
ZBTB4 mRNA results in increased susceptibility to artesunate |
CTD |
PMID:20144594 |
|
NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
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G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
affects response to substance |
ISO |
ERCC6 protein affects the susceptibility to ascaridole |
CTD |
PMID:22280988 |
|
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
affects response to substance |
ISO |
XPC protein affects the susceptibility to ascaridole |
CTD |
PMID:22280988 |
|
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression |
EXP |
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of AKT1 protein] |
CTD |
PMID:37661366 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
EXP |
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of BCL2 protein] |
CTD |
PMID:37661366 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] |
CTD |
PMID:24718106 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions increases secretion |
EXP |
Carbon Dioxide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] Carbon Dioxide results in increased secretion of CALCA protein |
CTD |
PMID:18052948 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] |
CTD |
PMID:24718106 |
|
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:24718106 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
increases response to substance |
ISO |
CRH protein results in increased susceptibility to Carbon Dioxide |
CTD |
PMID:8957205 |
|
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Dlg3 |
discs large MAGUK scaffold protein 3 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] |
CTD |
PMID:24718106 |
|
NCBI chr X:65,859,653...65,911,887
Ensembl chr X:65,860,172...65,910,322
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] |
CTD |
PMID:24718106 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Il2 |
interleukin 2 |
multiple interactions increases expression |
EXP ISO |
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 mRNA]; 3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 protein] Carbon Dioxide results in increased expression of IL2 mRNA; Carbon Dioxide results in increased expression of IL2 protein |
CTD |
PMID:37661366 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24718106 PMID:25004876 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24718106 PMID:25004876 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mir29a |
microRNA 29a |
multiple interactions |
ISO |
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which results in increased expression of MIR29A mRNA |
CTD |
PMID:29980036 |
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NCBI chr 4:59,650,608...59,650,695
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G |
Neil1 |
nei-like DNA glycosylase 1 |
affects abundance |
ISO |
NEIL1 affects the abundance of Carbon Dioxide |
CTD |
PMID:21285402 |
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NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
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G |
Ngb |
neuroglobin |
affects binding |
ISO |
Carbon Dioxide binds to [Heme binds to NGB protein] |
CTD |
PMID:16684569 |
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NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Carbon Dioxide] |
CTD |
PMID:21324916 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Rapgef3 |
Rap guanine nucleotide exchange factor 3 |
multiple interactions |
ISO |
[RAPGEF3 protein affects the susceptibility to Dietary Fats] which affects the chemical synthesis of Carbon Dioxide |
CTD |
PMID:27381457 |
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NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
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G |
Slc9a1 |
solute carrier family 9 member A1 |
affects response to substance |
EXP |
SLC9A1 protein affects the susceptibility to Carbon Dioxide |
CTD |
PMID:16831598 |
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NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
[[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide]; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide] |
CTD |
PMID:19243126 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Syncrip |
synaptotagmin binding, cytoplasmic RNA interacting protein |
multiple interactions |
ISO |
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which affects the expression of SYNCRIP mRNA |
CTD |
PMID:29980036 |
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NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
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G |
Syngap1 |
synaptic Ras GTPase activating protein 1 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] |
CTD |
PMID:24718106 |
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NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
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G |
Tpi1 |
triosephosphate isomerase 1 |
increases expression |
EXP |
Carbon Dioxide results in increased expression of TPI1 mRNA |
CTD |
PMID:14762718 |
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NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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G |
Trh |
thyrotropin releasing hormone |
increases response to substance |
ISO |
TRH protein results in increased susceptibility to Carbon Dioxide |
CTD |
PMID:8957205 |
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NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
increases activity |
EXP |
Carbon Dioxide results in increased activity of TRPA1 protein |
CTD |
PMID:20881114 |
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NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
affects response to substance |
EXP |
TRPV1 protein affects the susceptibility to Carbon Dioxide |
CTD |
PMID:16831598 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases activity |
EXP |
Carbon Monoxide results in increased activity of ABCC2 protein |
CTD |
PMID:13678533 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions increases expression |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein |
CTD |
PMID:19356108 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adm |
adrenomedullin |
increases expression |
EXP |
Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein |
CTD |
PMID:10666155 |
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NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Agr2 |
anterior gradient 2, protein disulphide isomerase family member |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA |
CTD |
PMID:29621558 |
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NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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G |
Agt |
angiotensinogen |
decreases response to substance |
ISO |
AGT protein results in decreased susceptibility to Carbon Monoxide |
CTD |
PMID:18174886 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO EXP |
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein] Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:17179207 PMID:18037988 PMID:18215737 PMID:18845810 PMID:19356108 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
increases activity multiple interactions |
EXP |
Carbon Monoxide results in increased activity of ALAD protein Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein] |
CTD |
PMID:1032310 PMID:6740708 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Areg |
amphiregulin |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA |
CTD |
PMID:29621558 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Bach1 |
BTB domain and CNC homolog 1 |
decreases phosphorylation |
ISO |
Carbon Monoxide results in decreased phosphorylation of BACH1 protein |
CTD |
PMID:18845810 |
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NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] |
CTD |
PMID:18037988 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions |
ISO |
BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] |
CTD |
PMID:11880364 |
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NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions decreases expression |
EXP |
Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein Carbon Monoxide results in decreased expression of BDNF mRNA |
CTD |
PMID:27113706 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] |
CTD |
PMID:11880364 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity |
EXP ISO |
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP3 mRNA]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]] Carbon Monoxide results in increased expression of CASP3 protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA Carbon Monoxide results in increased activity of CASP3 protein |
CTD |
PMID:17173083 PMID:19356108 PMID:19520142 PMID:25562542 PMID:31268311 PMID:37860845 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases activity |
EXP |
Carbon Monoxide results in increased activity of CASP7 protein |
CTD |
PMID:25562542 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions |
EXP ISO |
Carbon Monoxide results in increased activity of CASP8 protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA |
CTD |
PMID:25562542 PMID:31268311 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions increases expression |
EXP ISO |
Carbon Monoxide results in increased activity of CASP9 protein sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 mRNA]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 protein] Carbon Monoxide results in increased expression of CASP9 mRNA; Carbon Monoxide results in increased expression of CASP9 protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA |
CTD |
PMID:25562542 PMID:31268311 PMID:37860845 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases expression |
ISO EXP |
CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein] Carbon Monoxide results in decreased expression of CAT protein CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein] |
CTD |
PMID:17179207 PMID:18845810 PMID:34032369 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl1 |
C-C motif chemokine ligand 1 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA |
CTD |
PMID:29621558 |
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NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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G |
Cd86 |
CD86 molecule |
decreases expression |
EXP |
Carbon Monoxide results in decreased expression of CD86 protein |
CTD |
PMID:12201358 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Clca1 |
chloride channel accessory 1 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA |
CTD |
PMID:29621558 |
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NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
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G |
Col11a1 |
collagen type XI alpha 1 chain |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA |
CTD |
PMID:29621558 |
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NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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G |
Crp |
C-reactive protein |
increases expression |
ISO |
Carbon Monoxide results in increased expression of CRP protein |
CTD |
PMID:18629312 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA |
CTD |
PMID:29621558 |
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NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)] |
CTD |
PMID:1903091 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:10581206 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)] |
CTD |
PMID:1903091 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity multiple interactions |
ISO EXP |
Carbon Monoxide results in decreased activity of CYP2E1 protein Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)] |
CTD |
PMID:1903091 PMID:15036350 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Dnm1l |
dynamin 1-like |
multiple interactions increases expression |
EXP |
sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of DNM1L protein] |
CTD |
PMID:37860845 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Duox2 |
dual oxidase 2 |
increases expression decreases expression |
EXP |
Carbon Monoxide results in increased expression of DUOX2 mRNA Carbon Monoxide results in decreased expression of DUOX2 protein |
CTD |
PMID:29223502 |
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NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
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G |
Edn1 |
endothelin 1 |
increases expression multiple interactions |
EXP ISO |
Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein] |
CTD |
PMID:11781074 PMID:12969895 PMID:20197249 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]] |
CTD |
PMID:22046279 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Epo |
erythropoietin |
increases expression |
EXP |
Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein |
CTD |
PMID:9263988 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
increases expression |
EXP |
Carbon Monoxide results in increased expression of ERO1A mRNA |
CTD |
PMID:12752442 |
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NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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G |
Ezr |
ezrin |
multiple interactions |
ISO |
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in decreased expression of EZR protein |
CTD |
PMID:37141245 |
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NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
Fgb |
fibrinogen beta chain |
multiple interactions |
ISO |
FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] |
CTD |
PMID:19750100 |
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NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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G |
Foxp3 |
forkhead box P3 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of FOXP3 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter |
CTD |
PMID:29317916 PMID:33603036 |
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NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Gabpa |
GA binding protein transcription factor subunit alpha |
increases expression multiple interactions |
ISO EXP |
Carbon Monoxide results in increased expression of GABPA mRNA Carbon Monoxide results in increased expression of GABPA protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter] |
CTD |
PMID:17179207 |
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NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605
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G |
Gata4 |
GATA binding protein 4 |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein] |
CTD |
PMID:18037988 |
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NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
EXP |
Carbon Monoxide results in increased expression of GCLC mRNA [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA |
CTD |
PMID:34032369 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gpr182 |
G protein-coupled receptor 182 |
increases expression |
EXP |
Carbon Monoxide results in increased expression of GPR182 mRNA |
CTD |
PMID:10666155 |
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NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] |
CTD |
PMID:18037988 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases phosphorylation |
ISO |
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein] Carbon Monoxide results in increased phosphorylation of GSK3B protein |
CTD |
PMID:18037988 PMID:18845810 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases chemical synthesis increases expression increases activity |
ISO EXP |
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA] HMOX1 protein results in increased chemical synthesis of Carbon Monoxide [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] Carbon Monoxide results in increased expression of HMOX1 protein Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein] |
CTD |
PMID:11880364 PMID:16365149 PMID:18037988 PMID:18845810 PMID:19520142 PMID:21444764 PMID:25348283 PMID:29165873 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hmox2 |
heme oxygenase 2 |
multiple interactions affects chemical synthesis affects abundance |
EXP |
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein] HMOX2 protein affects the chemical synthesis of Carbon Monoxide HMOX2 protein affects the abundance of Carbon Monoxide |
CTD |
PMID:11342580 PMID:12969895 |
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NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP ISO |
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:19356108 PMID:19608869 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein] [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IFNG gene |
CTD |
PMID:16365149 PMID:29621558 PMID:33603036 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions increases expression |
ISO EXP |
Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein] [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL10 gene (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]] Carbon Monoxide results in increased expression of IL10 mRNA |
CTD |
PMID:21444764 PMID:31732924 PMID:33603036 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] |
CTD |
PMID:16365149 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA |
CTD |
PMID:29621558 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein |
CTD |
PMID:29621558 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
decreases response to substance multiple interactions |
ISO |
Carbon Monoxide results in decreased susceptibility to IL18 protein Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] |
CTD |
PMID:18215737 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
decreases expression multiple interactions increases expression |
ISO EXP |
Carbon Monoxide results in decreased expression of IL1B protein (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]] |
CTD |
PMID:21444764 PMID:31732924 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
increases expression multiple interactions |
EXP |
Carbon Monoxide results in increased expression of IL1RL1 protein (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]] |
CTD |
PMID:31732924 |
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NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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G |
Il33 |
interleukin 33 |
multiple interactions increases expression |
EXP |
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]] |
CTD |
PMID:31732924 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il4 |
interleukin 4 |
decreases expression multiple interactions |
ISO EXP |
Carbon Monoxide results in decreased expression of IL4 protein [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL4 gene [Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein; iodopravadoline inhibits the reaction [[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein] [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein |
CTD |
PMID:21444764 PMID:29621558 PMID:31732924 PMID:33603036 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] |
CTD |
PMID:18629312 PMID:19608869 PMID:19750100 PMID:31268311 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf8 |
interferon regulatory factor 8 |
decreases activity |
ISO |
Carbon Monoxide results in decreased activity of IRF8 protein |
CTD |
PMID:16365149 |
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NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] |
CTD |
PMID:18845810 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] |
CTD |
PMID:11880364 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mbp |
myelin basic protein |
affects response to substance |
ISO |
MBP polymorphism affects the susceptibility to Carbon Monoxide |
CTD |
PMID:36481359 |
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NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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G |
Mfn2 |
mitofusin 2 |
multiple interactions decreases expression |
EXP |
sulforaphane affects the reaction [Carbon Monoxide results in decreased expression of MFN2 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of MFN2 mRNA] Carbon Monoxide results in decreased expression of MFN2 mRNA; Carbon Monoxide results in decreased expression of MFN2 protein |
CTD |
PMID:37860845 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mir1224 |
microRNA 1224 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA |
CTD |
PMID:31268311 |
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NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986
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G |
Mir186 |
microRNA 186 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA |
CTD |
PMID:31268311 |
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NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891
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G |
Mir21 |
microRNA 21 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA |
CTD |
PMID:31268311 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir342 |
microRNA 342 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA |
CTD |
PMID:31268311 |
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NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367
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G |
Mir374b |
microRNA 374b |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA |
CTD |
PMID:31268311 |
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NCBI chr X:68,591,732...68,591,799
Ensembl chr X:68,591,732...68,591,799
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G |
Mir615 |
microRNA 615 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA |
CTD |
PMID:31268311 |
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NCBI chr 7:134,151,887...134,151,978
Ensembl chr 7:134,151,887...134,151,978
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G |
Mir93 |
microRNA 93 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA |
CTD |
PMID:31268311 |
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NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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G |
Mirlet7i |
microRNA let-7i |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA |
CTD |
PMID:31268311 |
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NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
Carbon Monoxide results in increased expression of MMP9 mRNA |
CTD |
PMID:20197249 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
EXP |
[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein; iodopravadoline inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein] |
CTD |
PMID:31732924 |
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NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Ndrg1 |
N-myc downstream regulated 1 |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein] |
CTD |
PMID:11006124 |
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NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression increases localization decreases phosphorylation |
ISO EXP |
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA] Carbon Monoxide results in increased expression of NFE2L2 mRNA; Carbon Monoxide results in increased expression of NFE2L2 protein [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]; NFE2L2 protein promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 mRNA] Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein |
CTD |
PMID:18845810 PMID:25348283 PMID:34032369 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] |
CTD |
PMID:11880364 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ngf |
nerve growth factor |
affects expression multiple interactions |
EXP |
Carbon Monoxide affects the expression of NGF mRNA Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein |
CTD |
PMID:27113706 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO EXP |
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] Carbon Monoxide results in decreased expression of NOS2 protein |
CTD |
PMID:12201358 PMID:22046279 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein |
CTD |
PMID:19356108 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppa |
natriuretic peptide A |
increases expression |
EXP |
Carbon Monoxide results in increased expression of NPPA mRNA |
CTD |
PMID:11781074 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nrf1 |
nuclear respiratory factor 1 |
multiple interactions increases expression increases localization |
ISO EXP |
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter] Carbon Monoxide results in increased expression of NRF1 protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]] Carbon Monoxide results in increased expression of NRF1 mRNA |
CTD |
PMID:17179207 PMID:18845810 |
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NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G |
Ntf3 |
neurotrophin 3 |
decreases expression multiple interactions |
EXP |
Carbon Monoxide results in decreased expression of NTF3 mRNA Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein |
CTD |
PMID:27113706 |
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NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
EXP |
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein |
CTD |
PMID:19356108 |
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NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pla2g7 |
phospholipase A2 group VII |
affects expression |
ISO |
Carbon Monoxide affects the expression of PLA2G7 |
CTD |
PMID:21356620 |
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NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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G |
Polg |
DNA polymerase gamma, catalytic subunit |
increases expression |
ISO |
Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein |
CTD |
PMID:17179207 |
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NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] |
CTD |
PMID:22046279 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression multiple interactions |
ISO EXP |
Carbon Monoxide results in increased expression of PPARGC1A mRNA Carbon Monoxide results in increased expression of PPARGC1A protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein] |
CTD |
PMID:17179207 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prg2 |
proteoglycan 2, pro eosinophil major basic protein |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA |
CTD |
PMID:29621558 |
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NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions decreases expression |
EXP |
sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of PRKAA2 mRNA] |
CTD |
PMID:37860845 |
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NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] |
CTD |
PMID:18215737 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Rel |
REL proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] |
CTD |
PMID:11880364 |
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NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] |
CTD |
PMID:11880364 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Selp |
selectin P |
increases expression |
ISO |
Carbon Monoxide results in increased expression of SELP protein modified form |
CTD |
PMID:18629312 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Sftpd |
surfactant protein D |
multiple interactions |
ISO |
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in increased expression of SFTPD protein |
CTD |
PMID:37141245 |
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NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression |
ISO |
Carbon Monoxide results in decreased expression of SOD1 protein |
CTD |
PMID:18629312 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases expression |
ISO EXP |
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA] Carbon Monoxide results in increased expression of SOD2 protein |
CTD |
PMID:17179207 PMID:18037988 PMID:18845810 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sostdc1 |
sclerostin domain containing 1 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA |
CTD |
PMID:29621558 |
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NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579
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G |
Tfam |
transcription factor A, mitochondrial |
increases expression multiple interactions |
ISO EXP |
Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]] |
CTD |
PMID:17179207 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression decreases expression decreases response to substance |
EXP ISO |
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]] Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells Carbon Monoxide results in decreased susceptibility to TNF protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] Carbon Monoxide results in decreased expression of TNF protein |
CTD RGD |
PMID:11880364 PMID:17173083 PMID:19356108 PMID:19608869 PMID:21444764 PMID:31268311 PMID:31732924 PMID:18972563 More...
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RGD:15023490 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
increases expression |
ISO |
Carbon Monoxide results in increased expression of TNFRSF1B protein modified form |
CTD |
PMID:18629312 |
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NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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G |
Tnfsf4 |
TNF superfamily member 4 |
multiple interactions |
ISO |
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA |
CTD |
PMID:29621558 |
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NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO |
UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:22046279 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Vasp |
vasodilator-stimulated phosphoprotein |
decreases phosphorylation |
ISO |
Carbon Monoxide results in decreased phosphorylation of VASP protein |
CTD |
PMID:26582457 |
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NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO EXP |
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:19356108 PMID:19608869 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Xdh |
xanthine dehydrogenase |
increases activity increases metabolic processing |
EXP |
Carbon Monoxide results in increased activity of XDH protein Carbon Monoxide results in increased metabolism of XDH protein |
CTD |
PMID:1447108 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
ergosterol-5,8-peroxide results in increased activity of CASP3 protein |
CTD |
PMID:20100469 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
increases metabolic processing |
ISO |
AKR1C1 protein results in increased metabolism of prostaglandin G2 |
CTD |
PMID:8573067 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases abundance |
ISO |
[PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; [PTGS2 protein results in increased abundance of prostaglandin G2] inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] |
CTD |
PMID:12538810 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Gstm2 |
glutathione S-transferase mu 2 |
affects metabolic processing |
ISO |
GSTM2 protein affects the metabolism of Prostaglandin H2 |
CTD |
PMID:10905636 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
affects metabolic processing |
ISO |
GSTM3 protein affects the metabolism of Prostaglandin H2 |
CTD |
PMID:10905636 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Ptgds |
prostaglandin D2 synthase |
increases metabolic processing |
EXP |
PTGDS protein results in increased metabolism of Prostaglandin H2 |
CTD |
PMID:22043816 |
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NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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