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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrous acid
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Accession:CHEBI:25567 term browser browse the term
Definition:A nitrogen oxoacid that has formula HNO2.
Synonyms:exact_synonym: dioxonitric acid;   hydrogen dioxonitrate(1-);   hydroxidooxidonitrogen
 related_synonym: Formula=HNO2;   HNO2;   InChI=1S/HNO2/c2-1-3/h(H,2,3);   InChIKey=IOVCWXUNBOPUCH-UHFFFAOYSA-N;   SMILES=[H]ON=O;   [NO(OH)];   nitrosyl hydroxide
 xref: CAS:7782-77-6;   Gmelin:983;   KEGG:C00088;   PDBeChem:NO2
 cyclic_relationship: is_conjugate_acid_of CHEBI:16301


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isobutyl nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf1 fibroblast growth factor 1 increases expression ISO isobutyl nitrite results in increased expression of FGF1 mRNA CTD PMID:16288974 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf4 fibroblast growth factor 4 increases expression ISO isobutyl nitrite results in increased expression of FGF4 mRNA CTD PMID:16288974 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases expression EXP isobutyl nitrite results in increased expression of GGT5 mRNA CTD PMID:9374738 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isobutyl nitrite results in increased expression of HMOX1 mRNA CTD PMID:16288974 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO isobutyl nitrite results in increased expression of HSPA4 mRNA CTD PMID:16288974 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO isobutyl nitrite results in increased expression of PF4 mRNA CTD PMID:16288974 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Smad7 SMAD family member 7 increases expression ISO isobutyl nitrite results in increased expression of SMAD7 mRNA CTD PMID:16288974 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO isobutyl nitrite results in increased expression of VEGFA mRNA CTD PMID:16288974 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO isobutyl nitrite results in increased expression of VEGFD mRNA CTD PMID:16288974 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
nitrites term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein modified form results in increased abundance of Nitrites CTD PMID:28299329 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ak1 adenylate kinase 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein CTD PMID:22892143 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Cp ceruloplasmin increases abundance
multiple interactions		 ISO
EXP		 CP protein results in increased abundance of Nitrites
SN50 peptide inhibits the reaction [CP protein results in increased abundance of Nitrites]
SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites]		 CTD PMID:17727827 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cs citrate synthase multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of CS protein CTD PMID:22892143 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [Gentamicins results in increased expression of EDNRB protein] which results in increased abundance of Nitrites CTD PMID:15200423 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Epo erythropoietin increases abundance
multiple interactions		 ISO EPO protein results in increased abundance of Nitrites
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]		 CTD PMID:23384249 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Fcer2 Fc epsilon receptor II affects chemical synthesis ISO FCER2 protein affects the chemical synthesis of Nitrites CTD PMID:11500085 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions
increases abundance		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]
2,2'-dihydroxychalcone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; aristolochic acid I inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; Industrial Waste inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; pyrrolidine dithiocarbamic acid inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [sulforaphane inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; Tosyllysine Chloromethyl Ketone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]		 CTD PMID:7532384 PMID:9918806 PMID:10532951 PMID:10903806 PMID:10967106 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases secretion
increases chemical synthesis		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; 8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Nitrites]
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; oxymatrine inhibits the reaction [IL1B protein results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]
IL1B protein results in increased abundance of Nitrites; IL1B results in increased abundance of Nitrites		 CTD PMID:8904084 PMID:9436821 PMID:10532951 PMID:10903806 PMID:10967106 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites] CTD PMID:9918806 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Lpo lactoperoxidase multiple interactions ISO [LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites CTD PMID:22434701 NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Nitrites inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein] CTD PMID:26614570 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mst1r macrophage stimulating 1 receptor multiple interactions ISO MST1R protein affects the reaction [nickel sulfate results in increased abundance of Nitrites] CTD PMID:11751209 NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Nitrites co-treated with Oxygen deficiency] results in increased expression of NFE2L2 mRNA		 CTD PMID:22892143 PMID:23942037 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 [linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites; [Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Oxidopamine results in increased expression of NOS2 protein] which results in increased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [testosterone enanthate results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]
[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Zymosan results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dronabinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; ganglioside, GD1a analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1a inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Hydrolyzable Tannins inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Leukotriene C4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; neurostatin inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Prazosin inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; trisialoganglioside GT1 analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; trisialoganglioside GT1 inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ZM 230487 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]		 CTD PMID:7532384 PMID:8700141 PMID:11405284 PMID:11454666 PMID:17566059 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP		 [NOS3 intron polymorphism co-treated with Methylmercury Compounds] results in decreased abundance of Nitrites
[[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites		 CTD PMID:17566059 PMID:22134029 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO NT5E protein affects the reaction [nimesulide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Nitrites]] CTD PMID:27188793 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [GW 7647 binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites] CTD PMID:17891158 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA; PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]; splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA; P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA] CTD PMID:22892143 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites; Nitrites promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide] CTD PMID:19243126 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of TFAM mRNA CTD PMID:22892143 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites] CTD PMID:19573522 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance		 ISO
EXP		 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrites]
TNF protein results in increased abundance of Nitrites
[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]; Triglycerides inhibits the reaction [TNF protein affects the abundance of Nitrites]		 CTD PMID:7532384 PMID:9918806 PMID:15659313 PMID:16140881 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein		 CTD PMID:12414318 PMID:26231821 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of ACTA2 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]		 CTD PMID:33030083 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]		 CTD PMID:28266762 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]		 CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]		 CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]		 CTD PMID:28833918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
increases activity		 ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein		 CTD PMID:26231821 PMID:31476334 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd68 Cd68 molecule increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of CD68 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein]		 CTD PMID:33030083 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Crp C-reactive protein multiple interactions
increases expression		 EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762 PMID:28833918 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Sodium Nitrite results in increased expression of H2AX protein modified form CTD PMID:31476334 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]		 CTD PMID:28000380 PMID:28266762 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions		 ISO
EXP		 Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
Sodium Nitrite results in increased expression of IL1B protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein]		 CTD PMID:16581224 PMID:33030083 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression		 ISO
EXP		 Sodium Nitrite results in increased secretion of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]		 CTD PMID:16581224 PMID:28266762 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression		 EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]		 CTD PMID:28000380 PMID:28266762 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]		 CTD PMID:28266762 PMID:33030083 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions		 ISO
EXP		 Sodium Nitrite results in increased expression of TNF mRNA
Sodium Nitrite results in increased secretion of TNF protein
Sodium Nitrite results in increased expression of TNF protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]		 CTD PMID:16581224 PMID:28266762 PMID:28833918 PMID:33030083 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]		 CTD PMID:28266762 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          nitrogen atom 19003
            nitrogen molecular entity 19003
              nitrogen oxoacid 283
                nitrous acid 63
                  hyponitrite 0
                  nitrites + 63
                  nitrosooxy group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19586
                        oxygen atom 19558
                          oxygen molecular entity 19558
                            hydroxides 19366
                              oxoacid 18804
                                pnictogen oxoacid 14996
                                  nitrogen oxoacid 283
                                    nitrous acid 63
                                      hyponitrite 0
                                      nitrites + 63
                                      nitrosooxy group 0
paths to the root