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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:neurotransmitter
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Accession:CHEBI:25512 term browser browse the term
Definition:An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
Synonyms:related_synonym: neurotransmitters
 xref: Wikipedia:Neurotransmitter


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(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions		 EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP Nitric Oxide deficiency results in increased activity of KNG1 protein modified form CTD PMID:10805402 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081 		JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000 		JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases response to substance
multiple interactions		 EXP AGT protein modified form results in increased susceptibility to Serotonin
Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]; Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]		 CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G EDN1 endothelin 1 increases activity EXP Serotonin results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 498
    role 498
      biological role 498
        molecular messenger 52
          neurotransmitter 15
            (R)-noradrenaline + 7
            5-hydroxytryptophan + 0
            L-aspartic acid + 0
            L-glutamic acid + 0
            Leu-enkephalin 0
            acetylcholine + 3
            anandamide + 0
            beta-alanine + 0
            beta-endorphin 0
            carbon monoxide 0
            choline + 1
            corticotropin-releasing hormone + 0
            gamma-aminobutyric acid + 0
            glycine + 0
            histamine + 0
            m-tyramine 0
            neurotensin 0
            nitric oxide 2
            octopamine + 0
            pterostilbene 0
            serotonin + 2
            substance P 0
            tyramine + 0
            tyraminium 0
paths to the root