Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molybdenum molecular entity
go back to main search page
Accession:CHEBI:25370 term browser browse the term
Synonyms:related_synonym: molybdenum compounds;   molybdenum molecular entities



show annotations for term's descendants           Sort by:
molybdate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP molybdate inhibits the reaction [Potassium Chloride inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]] CTD PMID:3015922 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO molybdate results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car4 carbonic anhydrase 4 decreases activity ISO molybdate results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
JBrowse link
G Car5a carbonic anhydrase 5A decreases activity ISO molybdate results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
JBrowse link
G Car9 carbonic anhydrase 9 decreases activity ISO molybdate results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Ins1 insulin 1 multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] CTD PMID:1321133 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Insr insulin receptor multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein CTD PMID:1321133 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs4 insulin receptor substrate 4 multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] CTD PMID:1321133 NCBI chr  X:105,344,020...105,360,004 JBrowse link
G Ivl involucrin decreases expression ISO molybdate results in decreased expression of IVL protein CTD PMID:7848924 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP molybdate results in increased expression of NR3C1 protein CTD PMID:3015922 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO PAPSS1 protein binds to and affects the metabolism of molybdate CTD PMID:15065880 NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of PTPN1 protein CTD PMID:34320920 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of XDH protein CTD PMID:34320920 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
molybdenum trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd80 Cd80 molecule increases secretion ISO molybdenum chloride results in increased secretion of CD80 protein CTD PMID:19844976 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO molybdenum chloride results in increased secretion of IL1B protein CTD PMID:19844976 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion ISO molybdenum chloride results in increased secretion of IL6 protein CTD PMID:19844976 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO molybdenum chloride results in increased secretion of TNF protein CTD PMID:19844976 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
molybdenum trioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
ISO molybdenum trioxide results in decreased activity of CAT protein
chromous chloride affects the reaction [molybdenum trioxide results in decreased activity of CAT protein]; molybdenum trioxide affects the reaction [chromous chloride results in decreased activity of CAT protein]
CTD PMID:30389395 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [molybdenum trioxide results in increased abundance of Molybdenum] inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:33038468 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
ISO molybdenum trioxide results in increased activity of NQO1 protein
molybdenum trioxide results in increased expression of NQO1 mRNA
CTD PMID:9029048 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO [molybdenum trioxide results in increased abundance of Molybdenum] which results in decreased expression of UQCRC1 mRNA CTD PMID:33038468 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
JBrowse link
sodium molybdate (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO
EXP
sodium molybdate(VI) promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) results in increased activity of AHR protein
CTD PMID:3040233 PMID:8079350 PMID:8395819 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of PTPN1 protein CTD PMID:34320920 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [sodium molybdate(VI) results in increased abundance of molybdate] which results in decreased activity of XDH protein CTD PMID:34320920 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
tetrathiomolybdate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO tetrathiomolybdate results in increased phosphorylation of ACACA protein CTD PMID:24218578 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA CTD PMID:19323979 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of AKT1 protein CTD PMID:37290678 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Angpt2 angiopoietin 2 increases expression ISO tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA CTD PMID:19323979 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G App amyloid beta precursor protein multiple interactions
affects binding
ISO [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AQP1 mRNA CTD PMID:19323979 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions
decreases expression
ISO tetrathiomolybdate inhibits the reaction [ATP7B gene mutant form results in increased abundance of Copper]
tetrathiomolybdate results in decreased expression of ATP7B protein
CTD PMID:11803042 PMID:37290678 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrathiomolybdate results in increased expression of BAX protein CTD PMID:37290678 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
ISO tetrathiomolybdate analog results in increased expression of BCL2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2 protein
tetrathiomolybdate results in decreased expression of BCL2 protein
CTD PMID:19323979 PMID:37290678 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of BCL2L11 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of BCL2L11 protein CTD PMID:22276220 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO tetrathiomolybdate analog results in increased expression of BCL2L2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2L2 protein CTD PMID:19323979 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G C1h19orf33 similar to human chromosome 19 open reading frame 33 decreases expression ISO tetrathiomolybdate results in decreased expression of C19ORF33 mRNA CTD PMID:37290678 NCBI chr 1:84,549,830...84,550,666
Ensembl chr 1:84,549,831...84,550,664
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
[Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein
tetrathiomolybdate results in increased cleavage of CASP3 protein
CTD PMID:22276220 PMID:37290678 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of CCL2 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 protein]
CTD PMID:15541506 PMID:21724870 PMID:24225134 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO tetrathiomolybdate results in decreased expression of CCNB1 protein CTD PMID:37290678 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression
decreases expression
EXP
ISO
tetrathiomolybdate results in increased expression of CCS protein
tetrathiomolybdate results in decreased expression of CCS protein
CTD PMID:21784888 PMID:37290678 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cd40 CD40 molecule increases expression ISO tetrathiomolybdate analog results in increased expression of CD40 mRNA CTD PMID:19323979 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tetrathiomolybdate analog results in increased expression of CDKN1A protein CTD PMID:19323979 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 decreases expression ISO tetrathiomolybdate results in decreased expression of CEACAM6 mRNA CTD PMID:37290678 NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668
JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein] CTD PMID:16242529 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cldn18 claudin 18 decreases expression ISO tetrathiomolybdate results in decreased expression of CLDN18 mRNA CTD PMID:37290678 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
JBrowse link
G Cldn4 claudin 4 decreases expression ISO tetrathiomolybdate results in decreased expression of CLDN4 mRNA CTD PMID:37290678 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO tetrathiomolybdate results in increased expression of COL1A1 mRNA CTD PMID:37290678 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO tetrathiomolybdate results in increased expression of COL1A2 mRNA CTD PMID:37290678 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO tetrathiomolybdate results in increased expression of COL3A1 mRNA CTD PMID:37290678 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 decreases expression ISO tetrathiomolybdate results in decreased expression of COX17 protein CTD PMID:37290678 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression ISO tetrathiomolybdate analog results in increased expression of COX5B mRNA CTD PMID:19323979 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Cp ceruloplasmin decreases activity
decreases expression
decreases secretion
multiple interactions
ISO
EXP
tetrathiomolybdate results in decreased activity of CP protein
tetrathiomolybdate results in decreased expression of CP protein
tetrathiomolybdate results in decreased secretion of CP protein
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]
CTD PMID:10656425 PMID:12624602 PMID:21724870 PMID:21784888 PMID:24013775 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP tetrathiomolybdate results in decreased expression of CPT1A mRNA CTD PMID:21784888 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of CRABP2 mRNA CTD PMID:19323979 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression ISO tetrathiomolybdate analog results in increased expression of CREBZF mRNA CTD PMID:19323979 NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553
JBrowse link
G Csf3r colony stimulating factor 3 receptor increases expression ISO tetrathiomolybdate results in increased expression of CSF3R mRNA CTD PMID:37290678 NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
JBrowse link
G Cstb cystatin B decreases expression ISO tetrathiomolybdate results in decreased expression of CSTB mRNA CTD PMID:37290678 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO tetrathiomolybdate analog results in increased expression of CXCR4 mRNA CTD PMID:19323979 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
tetrathiomolybdate results in decreased expression of EGFR protein
CTD PMID:18480265 PMID:37290678 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eln elastin multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN protein CTD PMID:22276220 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO tetrathiomolybdate results in decreased expression of ERO1A mRNA CTD PMID:37290678 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Fbln1 fibulin 1 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 protein CTD PMID:22276220 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
JBrowse link
G Fbln5 fibulin 5 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
JBrowse link
G Fbn1 fibrillin 1 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 protein CTD PMID:22276220 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO tetrathiomolybdate results in decreased secretion of FGF1 protein CTD PMID:18400376 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:18480265 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO tetrathiomolybdate results in increased expression of FOS mRNA CTD PMID:37290678 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fpr1 formyl peptide receptor 1 increases expression ISO tetrathiomolybdate results in increased expression of FPR1 mRNA CTD PMID:37290678 NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A decreases expression ISO tetrathiomolybdate results in decreased expression of GPRC5A mRNA CTD PMID:37290678 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO tetrathiomolybdate analog results in increased expression of GPX3 mRNA CTD PMID:19323979 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO tetrathiomolybdate analog results in increased expression of GSR mRNA CTD PMID:19323979 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hbb hemoglobin subunit beta increases expression ISO tetrathiomolybdate results in increased expression of HBB mRNA CTD PMID:37290678 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein CTD PMID:22276220 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP tetrathiomolybdate results in decreased expression of HMGCS2 mRNA CTD PMID:21784888 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO tetrathiomolybdate analog results in decreased expression of RHAMM mRNA CTD PMID:19323979 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression
multiple interactions
EXP
ISO
tetrathiomolybdate results in decreased expression of HMOX1 protein
tetrathiomolybdate analog results in increased expression of HMOX1 mRNA; tetrathiomolybdate analog results in increased expression of HMOX1 protein
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]
CTD PMID:19323979 PMID:21784888 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of ICAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 protein]
CTD PMID:21724870 PMID:24225134 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO tetrathiomolybdate results in increased expression of IFITM2 mRNA CTD PMID:37290678 NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 increases expression ISO tetrathiomolybdate results in increased expression of IGFBP7 mRNA CTD PMID:37290678 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
JBrowse link
G Igll1 immunoglobulin lambda-like polypeptide 1 increases expression ISO tetrathiomolybdate results in increased expression of IGLL5 mRNA CTD PMID:37290678 NCBI chr11:84,138,847...84,142,238
Ensembl chr11:84,138,910...84,142,216
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] CTD PMID:21724870 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:16242529 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL2 protein] CTD PMID:16242529 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression
multiple interactions
ISO tetrathiomolybdate analog results in decreased expression of IL2RA mRNA
tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]
CTD PMID:19323979 PMID:23134680 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21724870 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO tetrathiomolybdate analog results in decreased expression of ITGB4 mRNA CTD PMID:19323979 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA CTD PMID:22276220 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO tetrathiomolybdate analog results in increased expression of JAG1 mRNA CTD PMID:19323979 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jchain joining chain of multimeric IgA and IgM increases expression ISO tetrathiomolybdate results in increased expression of JCHAIN mRNA CTD PMID:37290678 NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298
JBrowse link
G Klf2 KLF transcription factor 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of KLF2 mRNA CTD PMID:19323979 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Krt19 keratin 19 decreases expression ISO tetrathiomolybdate results in decreased expression of KRT19 mRNA CTD PMID:37290678 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt7 keratin 7 decreases expression ISO tetrathiomolybdate results in decreased expression of KRT7 mRNA CTD PMID:37290678 NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO tetrathiomolybdate results in decreased expression of LAMB3 mRNA CTD PMID:37290678 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lcn2 lipocalin 2 decreases expression ISO tetrathiomolybdate results in decreased expression of LCN2 mRNA CTD PMID:37290678 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lox lysyl oxidase multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO tetrathiomolybdate results in increased expression of LST1 mRNA CTD PMID:37290678 NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK1 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]
tetrathiomolybdate analog results in increased phosphorylation of MAPK1 protein
CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate analog results in increased phosphorylation of MAPK3 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] CTD PMID:25671100 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mgp matrix Gla protein increases expression ISO tetrathiomolybdate results in increased expression of MGP mRNA CTD PMID:37290678 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mnda myeloid cell nuclear differentiation antigen increases expression ISO tetrathiomolybdate results in increased expression of MNDA mRNA CTD PMID:37290678 NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of MTOR protein CTD PMID:37290678 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myo1f myosin IF increases expression ISO tetrathiomolybdate results in increased expression of MYO1F mRNA CTD PMID:37290678 NCBI chr 7:14,363,340...14,413,911
Ensembl chr 7:14,363,350...14,413,911
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO tetrathiomolybdate results in increased expression of NAMPT mRNA CTD PMID:37290678 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO tetrathiomolybdate results in increased expression of NCF1 mRNA CTD PMID:37290678 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO tetrathiomolybdate results in decreased expression of NDRG1 mRNA CTD PMID:37290678 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO tetrathiomolybdate analog affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:19323979 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tetrathiomolybdate results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein CTD PMID:24225134 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO tetrathiomolybdate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO tetrathiomolybdate results in decreased expression of PDGFRB protein CTD PMID:18480265 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of PIK3R1 protein CTD PMID:37290678 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plin2 perilipin 2 decreases expression ISO tetrathiomolybdate results in decreased expression of PLIN2 mRNA CTD PMID:37290678 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP tetrathiomolybdate results in decreased expression of PPARA mRNA CTD PMID:21784888 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prss1 serine protease 1 increases expression ISO tetrathiomolybdate results in increased expression of PRSS1 mRNA CTD PMID:37290678 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of PTGS2 mRNA CTD PMID:19323979 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of PTK2 protein CTD PMID:22276220 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein] CTD PMID:18480265 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression ISO tetrathiomolybdate results in increased expression of PTPRC mRNA CTD PMID:37290678 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Reg1a regenerating family member 1 alpha increases expression ISO tetrathiomolybdate results in increased expression of REG1A mRNA CTD PMID:37290678 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO tetrathiomolybdate results in increased expression of RGS2 mRNA CTD PMID:37290678 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 decreases expression ISO tetrathiomolybdate results in decreased expression of RICTOR protein CTD PMID:37290678 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Ripor2 RHO family interacting cell polarization regulator 2 increases expression ISO tetrathiomolybdate results in increased expression of RIPOR2 mRNA CTD PMID:37290678 NCBI chr17:40,323,748...40,547,482
Ensembl chr17:40,323,867...40,548,092
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO tetrathiomolybdate results in decreased phosphorylation of RPS6KB1 protein CTD PMID:37290678 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases expression ISO tetrathiomolybdate results in decreased expression of RPTOR protein CTD PMID:37290678 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G RT1-Ha RT1 class II, locus Ha increases expression ISO tetrathiomolybdate results in increased expression of HLA-DPA1 mRNA CTD PMID:37290678 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO tetrathiomolybdate results in increased expression of S100A8 mRNA CTD PMID:37290678 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO tetrathiomolybdate results in increased expression of S100A9 mRNA CTD PMID:37290678 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Sfn stratifin decreases expression ISO tetrathiomolybdate results in decreased expression of SFN mRNA CTD PMID:37290678 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO tetrathiomolybdate results in decreased expression of SLC2A1 mRNA CTD PMID:37290678 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
decreases expression
increases expression
ISO [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]
tetrathiomolybdate results in decreased expression of SLC31A1 protein
CTD PMID:22172574 PMID:22914438 PMID:37290678 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases response to substance ISO SLC31A2 mRNA results in decreased susceptibility to tetrathiomolybdate CTD PMID:24522273 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA CTD PMID:19323979 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
affects localization
decreases activity
multiple interactions
EXP
ISO
tetrathiomolybdate results in decreased expression of SOD1 protein
tetrathiomolybdate analog affects the localization of SOD1 protein
tetrathiomolybdate results in decreased activity of SOD1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
tetrathiomolybdate analog results in decreased expression of SOD1 mRNA
CTD PMID:18480265 PMID:19323979 PMID:21784888 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of SOD2 mRNA; tetrathiomolybdate analog results in increased expression of SOD2 protein CTD PMID:19323979 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases expression
increases activity
ISO [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]; tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter]
tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA
tetrathiomolybdate results in increased activity of SP1 protein
CTD PMID:22172574 PMID:22914438 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor decreases expression ISO tetrathiomolybdate results in decreased expression of SP3 CTD PMID:22172574 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO tetrathiomolybdate results in decreased expression of SPP1 mRNA CTD PMID:37290678 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srgn serglycin increases expression ISO tetrathiomolybdate results in increased expression of SRGN mRNA CTD PMID:37290678 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO tetrathiomolybdate results in decreased expression of TACSTD2 mRNA CTD PMID:37290678 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link
G Tagln transgelin increases expression ISO tetrathiomolybdate results in increased expression of TAGLN mRNA CTD PMID:37290678 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression EXP tetrathiomolybdate results in decreased expression of TFB1M mRNA CTD PMID:21784888 NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO tetrathiomolybdate results in decreased expression of TFF1 mRNA CTD PMID:37290678 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO tetrathiomolybdate results in decreased expression of TFF3 mRNA CTD PMID:37290678 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] CTD PMID:15541506 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tm4sf1 transmembrane 4 L six family member 1 decreases expression ISO tetrathiomolybdate results in decreased expression of TM4SF1 mRNA CTD PMID:37290678 NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:15541506 PMID:16242529 PMID:21724870 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:16242529 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
EXP
ISO
[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of TP53 protein
tetrathiomolybdate results in increased phosphorylation of TP53 protein
CTD PMID:22276220 PMID:37290678 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression ISO tetrathiomolybdate results in increased expression of TSC22D3 mRNA CTD PMID:37290678 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO tetrathiomolybdate analog results in increased expression of TXNRD1 mRNA CTD PMID:19323979 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of VCAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]
CTD PMID:21724870 PMID:24225134 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
EXP
ISO
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein
tetrathiomolybdate results in decreased expression of VEGFA protein
CTD PMID:16277669 PMID:22276220 PMID:37290678 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression ISO tetrathiomolybdate results in decreased expression of VEGFB protein CTD PMID:37290678 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      molecular entity 19878
        transition element molecular entity 17439
          chromium group molecular entity 6828
            molybdenum molecular entity 151
              elemental molybdenum + 0
              molybdenum coordination entity + 151
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  metal atom 18032
                    transition element atom 17576
                      d-block element atom 17571
                        chromium group element atom 7957
                          chromium group molecular entity 6828
                            molybdenum molecular entity 151
                              elemental molybdenum + 0
                              molybdenum coordination entity + 151
paths to the root